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Dissertations / Theses on the topic 'Synthetic division'

Author: Grafiati

Published: 30 May 2022

Last updated: 31 July 2025

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1

Torre, Paola. "Genetically encoded division machinery for cell free synthetic biology." Doctoral thesis, Università degli studi di Trento, 2013. https://hdl.handle.net/11572/369256.

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The de novo construction of cellular life requires, in part, the assembly of components that confer the ability to replicate. Herein we describe efforts to reconstitute parts of the Escherichia coli cell division machinery inside of water-in-oil emulsion compartments and synthetic phospholipid vesicles. The system was built with DNA and purified transcription and translation machinery housed in a compartment. A particular emphasis was placed on FtsZ, a protein that oligomerizes into a ring at the midcell and splits the cell into two. FtsZ does not contain a membrane interaction domain. In vivo

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2

Torre, Paola. "Genetically encoded division machinery for cell free synthetic biology." Doctoral thesis, University of Trento, 2013. http://eprints-phd.biblio.unitn.it/980/1/PhD_thesis_Paola_T5.pdf.

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The de novo construction of cellular life requires, in part, the assembly of components that confer the ability to replicate. Herein we describe efforts to reconstitute parts of the Escherichia coli cell division machinery inside of water-in-oil emulsion compartments and synthetic phospholipid vesicles. The system was built with DNA and purified transcription and translation machinery housed in a compartment. A particular emphasis was placed on FtsZ, a protein that oligomerizes into a ring at the midcell and splits the cell into two. FtsZ does not contain a membrane interaction domain. In vi

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3

Stokes, Andrew J. "Interferometric Synthetic Aperture Ladar Using Code Division Multiple Access Apertures." University of Dayton / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=dayton1511789594365428.

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4

Wahl, Mary Elizabeth. "A Synthetic Yeast Model for Differentiation and Division of Labor." Thesis, Harvard University, 2014. http://dissertations.umi.com/gsas.harvard:11515.

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To maintain high average fitness, populations must effect selection against the deleterious mutations that continuously arise de novo. Theoretical models of mutation-selection balance predict that the maximum tolerable mutation rate is much lower for organisms growing in colonies than for those in well-mixed liquid media due to drift imposed by competition for position along the growing colony front. Simplifying assumptions made in these models, including the irreversibility and fixed fitness cost of mutations, do not strictly hold in extant species. To explore the applicability of these model

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Canton, Bartholomew (Bartholomew John). "Engineering the interface between cellular chassis and synthetic biological systems." Thesis, Massachusetts Institute of Technology, 2008. http://hdl.handle.net/1721.1/44918.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Biological Engineering Division, 2008.<br>This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.<br>Includes bibliographical references (p. 165-176).<br>The aim of my thesis is to help enable the engineering of biological systems that behave in a predictable manner. Well-established techniques exist to engineer systems that behave as expected. Here, I apply such techniques to two aspects of the engineering of biological systems. First, I address th

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Silver, Matthew Robin. "Open collaborative system design : a strategic framework with application to synthetic biology." Thesis, Massachusetts Institute of Technology, 2010. http://hdl.handle.net/1721.1/63012.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Engineering Systems Division, 2010.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (p. 251-259).<br>Across technology industries and particularly at the cutting edge of biotechnology a debate is under way about the proper balance between open and closed - between co-developing products with shared information and open standards, versus using more traditional, closed, proprietary processes. Beyond the relative success of open source software to date, it is not clear how and whether open design processes mig

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7

Kelly, Jason R. (Jason Robert). "Tools and reference standards supporting the engineering and evolution of synthetic biological systems." Thesis, Massachusetts Institute of Technology, 2008. http://hdl.handle.net/1721.1/44917.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Biological Engineering Division, 2008.<br>This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.<br>Includes bibliographical references (p. 163-168).<br>Biological engineers have constructed a number of multi-part synthetic biological systems that conduct logical operations on input signals, produce oscillatory output signals, store memory, or produce desired products. However, very few of these genetically-encoded systems worked as originally desi

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Lu, Timothy K. (Timothy Kuan-Ta) 1981. "Combating biofilms and antibiotic resistance using synthetic biology." Thesis, Massachusetts Institute of Technology, 2008. http://hdl.handle.net/1721.1/43868.

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Thesis (Ph. D.)--Harvard-MIT Division of Health Sciences and Technology, 2008.<br>Includes bibliographical references (leaves 81-86).<br>Bacterial infections represent a significant source of morbidity and mortality. Biofilms and antibiotic resistance pose challenges to our future ability to treat bacterial diseases with antibiotics (1). Bacteria frequently live in biofilms, which are surface-associated communities encased in a hydrated extracellular polymeric substances (EPS) matrix (2, 3). Biofilms are crucial in the pathogenesis of many clinically-important infections and are difficult to e

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9

Regårdh, Pernilla C. (Pernilla Christina). "Safe, secure and ethical? : assessing and regulating risks associated with synthetic biology." Thesis, Massachusetts Institute of Technology, 2011. http://hdl.handle.net/1721.1/65509.

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Thesis (S.M. in Technology and Policy)--Massachusetts Institute of Technology, Engineering Systems Division, Technology and Policy Program, 2011.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (p. 116-127).<br>Synthetic biology is an emerging field, with a rapidly developing academic-industrial base and the promise of extensive product launches over the next few years. An intense debate over the risks and benefits of synthetic biology has developed even before commercialization. Nongovernmental organizations and official commissions have published over a dozen

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10

Holder, Sade A. "Linear frequency modulated signals vs orthogonal frequency division multiplexing signals for synthetic aperture radar systems." Thesis, Monterey, California: Naval Postgraduate School, 2014. http://hdl.handle.net/10945/42647.

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Approved for public release; distribution is unlimited<br>The goal of this thesis is to investigate the effects of an orthogonal frequency-division multiplexing (OFDM) signal versus a linear frequency modulated or chirp signal on simulated synthetic aperture radar (SAR) imagery. Various parameters of the transmitted signal, such as pulse duration, transmitted signal energy, bandwidth, and (specifically for the OFDM signal) number of subcarriers and transmission scheme were examined to determine which parameters are most important to reconstructing a SAR image. Matched filtering and interpolati

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McNamara, Julie H. (Julie Hutton). "Bridging gaps in synthetic biology oversight : iGEM as a testbed for proactive, adaptive risk management." Thesis, Massachusetts Institute of Technology, 2014. http://hdl.handle.net/1721.1/90057.

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Thesis: S.M. in Technology and Policy, Massachusetts Institute of Technology, Engineering Systems Division, Technology and Policy Program, 2014.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (pages 84-90).<br>On the surface, the emerging field of synthetic biology looks highly similar to that of genetic engineering. However, the two fields are based upon divergent underlying logic structures. Whereas genetic engineering affects change through localized modifications of existing organisms, synthetic biology attempts to fuse independent component parts to create

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12

Yeddanapudi, Neelima 1976. "Strategies for designing, testing and demonstrating safety : what synthetic biology can learn from retrospective cases." Thesis, Massachusetts Institute of Technology, 2009. http://hdl.handle.net/1721.1/59692.

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Thesis (S.M. in Technology and Policy)--Massachusetts Institute of Technology, Engineering Systems Division, 2009.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (p. 99-101).<br>Synthetic biology is an emerging technology field within the realm of genetic engineering, differing from traditional genetic engineering in that it focuses on the modularization of genetic parts and the creation of de novo organisms. Significant concerns over safety have been expressed. This research explores traditional engineering and biotechnology practices for overarching principle

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Lightfoot, Shlomiya. "Uncertainty in synthetic biology for release and possibilities for regulation under the Toxic Substances Control Act." Thesis, Massachusetts Institute of Technology, 2014. http://hdl.handle.net/1721.1/88400.

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Thesis: S.M. in Technology and Policy, Massachusetts Institute of Technology, Engineering Systems Division, Technology and Policy Program, 2014.<br>260<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (pages 52-64).<br>The emerging field of synthetic biology is developing rapidly and promises diverse applications. Many anticipated applications, particularly those involving release of engineered microbes into the environment or human bodies, have potential environmental and health implications. These implications, which present design challenges to engineers, stem

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Samuelsson, Magnus. "p57Kip2, a glucocorticoid-induced CDK inhibitor, involved in cell proliferation, apoptosis and differentiation /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-382-1/.

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S, Stetsenko N. "Methods of finding the solution of the equations." Thesis, National Aviation University, 2021. https://er.nau.edu.ua/handle/NAU/50701.

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1. Higher_engineering_mathematics / Grewal_B._S.; 2. https://courses.lumenlearning.com/suny-beginalgebra/chapter/3-2-1-the-substitution-method/ ; 3. https://sciencing.com/3-methods-solving-systems-equations-8644686.html .<br>Solving equations is given great importance. There are many different ways of solving algebraic equations that require a lot of different knowledge and are widely used. This is due to the fact that many geometric problems, problems in Physics, Chemistry, Biology and other sciences are solved with their help.

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Stewart, Neil. "Identifying genetic interactions of the spindle checkpoint in Caenorhabditis elegans." Thesis, University of North Texas, 2009. https://digital.library.unt.edu/ark:/67531/metadc12203/.

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Faithful segregation of chromosomes is ensured by the spindle checkpoint. If a kinetochore does not correctly attach to a microtubule the spindle checkpoint stops cell cycle progression until all chromosomes are attached to microtubules or tension is experienced while pulling the chromosomes. The C. elegans gene, san-1, is required for spindle checkpoint function and anoxia survival. To further understand the role of san-1 in the spindle checkpoint, an RNAi screen was conducted to identify genetic interactions with san-1. The kinetochore gene hcp-1 identified in this screen, was known to have

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Mouhoub, Asma. "All-inductive observation of linear dynamics and nonlinear processes of spin waves in synthetic antiferromagnets." Electronic Thesis or Diss., université Paris-Saclay, 2024. http://www.theses.fr/2024UPAST147.

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Les ondes de spin sont des excitations élémentaires de l’ordre ferromagnétique, et leurs propriétés, notamment la non-linéarité, les rendent intéressantes pour des applications comme le calcul neuromorphique et les dispositifs logiques magnoniques. Les antiferromagnétiques synthétiques (SAFs), constitués de deux couches ferromagnétiques séparées par une couche non magnétique, permettent une aimantation antiparallèle grâce à un couplage inter-couches. Ce couplage confère aux SAFs une grande flexibilité, les rendant particulièrement adaptés à l’étude de la non-linéarité des ondes de spin. L’util

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18

Manuse, Sylvie. "Régulation de la morphogenèse et de la division cellulaire du pneumocoque par phosphorylation : rôle de la sérine / thréonine kinase StkP et des protéines DivIVA, GpsB et MapZ." Thesis, Lyon 1, 2015. http://www.theses.fr/2015LYO10342.

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Malgré les modèles établis pour certaines bactéries, la morphogenèse de bactéries de formes atypiques est peu comprise. C'est le cas de la bactérie pathogène pour l'homme Streptococcus pneumoniae, ou pneumocoque, qui possède une forme ovo-diplococcale. Cependant, à mon arrivé au laboratoire, il avait été démontré qu'une sérine/thréonine protéine-kinase membranaire appelée StkP était indispensable à la division cellulaire et à la morphogenèse du pneumocoque. L'objectif de ma thèse a ainsi été de caractériser certains substrats de StkP et d'étudier leur rôle, ainsi que l'impact de leur phosphory

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Laforge, Nathalie. "Construction et évolution dirigée de consortia synthétiques mutualistes de Bacillus subtilis." Electronic Thesis or Diss., université Paris-Saclay, 2024. http://www.theses.fr/2024UPASL119.

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Dans les écosystèmes naturels, les micro-organismes vivent en communautés et interagissent entre eux. En façonnant la composition, la stabilité et la fonctionnalité des écosystèmes, les interactions microbiennes sont des éléments fondamentaux de ces communautés. Cependant, les mécanismes régissant ces interactions restent largement méconnus. Une approche pour étudier de tels mécanismes consiste à concevoir de manière rationnelle des interactions au sein d'organismes modèles. Ce travail vise donc à construire des consortia synthétiques, composés de deux souches de Bacillus subtilis modifiées gé

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20

Schweizer, Jakob. "Min-Protein Waves on Geometrically Structured Artificial Membranes." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2013. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-105880.

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Das stäbchenförmige Bakterium Escherichia coli teilt sich in zwei gleich große Tochterzellen. Dies ist nur möglich, wenn sich die Zelle in der Mitte teilt. Bei E. coli wird die Zellteilung durch den Zusammenschluss der FtsZ-Proteine an der Membran zum Z-Ring eingeleitet. Topologische Regulierung des Z-Ringes erfolgt durch räumlich-zeitliche Oszillationen von Min-Proteinen zwischen den beiden Zellpolen. MinC, MinD und MinE binden an und lösen sich von der Membran unter Hydrolyse von ATP und in antagonistischer Art und Weise, was zu einer alternierenden Ansammlung von MinC und MinD an den Zellpo

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Park, Jason (Jason Sun-Hyung). "Synthesis and error correction methods in gene fabrication." Thesis, Massachusetts Institute of Technology, 2006. http://hdl.handle.net/1721.1/37961.

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Thesis (M. Eng.)--Massachusetts Institute of Technology, Biological Engineering Division, 2006.<br>Includes bibliographical references (leaves 56-59).<br>Gene Fabrication technology involves the development and optimization of methods relevant to the in vitro synthesis of any given target gene sequence(s) in the absence of template. The driving purpose of this field of research is to bring about the capability for on-demand fabrication of a DNA construct of arbitrary length and sequence quickly, efficiently, and cost-effectively. The first part of this document describes many of the important

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Egan, Alexander John Frederick. "Regulation of peptidoglycan synthesis during cell division in Escherichia coli." Thesis, University of Newcastle upon Tyne, 2014. http://hdl.handle.net/10443/2531.

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Bacteria surround their cytoplasmic membrane with an essential, stress-bearing macromolecule, the peptidoglycan (PG) layer. During growth and division cells extend this layer through the action of membrane-anchored peptidoglycan synthases. Presumably, sacculus growth is facilitated by dynamic multiprotein complexes which are guided by cytoskeletal elements. These complexes contain all the necessary peptidoglycan synthases and hydrolases for the enlargement of the sacculus, along with their regulators. Biochemical and genetic data gathered in recent years provides evidence for the existence of

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Turlington, Ralph Donald III. "Mitigating security issues in the evolving DNA synthesis industry." Thesis, Massachusetts Institute of Technology, 2013. http://hdl.handle.net/1721.1/80897.

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Thesis (S.M. in Technology and Policy)--Massachusetts Institute of Technology, Engineering Systems Division, 2013.<br>This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.<br>Cataloged from student-submitted PDF version of thesis.<br>Includes bibliographical references (p. 102-108).<br>DNA synthesis technologies are advancing at exponential rates, with production of ever longer, more complex, and less expensive sequences of double stranded DNA. This has fostered development of industrial scale design,

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Jorge, Ana Maria. "Insights into cell wall synthesis and cell division in Staphylococcus aureus." Doctoral thesis, Universidade Nova de Lisboa. Instituto de Tecnologia Química e Biológica, 2012. http://hdl.handle.net/10362/8592.

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Dissertation presented to obtain the Ph.D degree in Biology<br>Staphylococcus aureus is a gram-positive bacterial pathogen that besides persistently colonizing healthy individuals, is responsible for a large number of hospital-associated bacterial infections. The extraordinary capacity of S. aureus to acquire resistance to antibiotics led to the emergence of highly resistant strains, mainly methicillin-resistant S. aureus (MRSA) strains, that are a major cause of soft skin and tissue infections and bacteremia. In one third of European countries, including Portugal, more than 25% of S. aureus i

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Uppala, Sathyadev V. "Analysis and synthesis of linear multiuser detectors /." Thesis, Connect to this title online; UW restricted, 1998. http://hdl.handle.net/1773/6065.

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Jain, Siddhartha Ph D. Massachusetts Institute of Technology. "Synthesis of a hydrogel-based vaccine to mimic dendritic cell responses to pathogens." Thesis, Massachusetts Institute of Technology, 2006. http://hdl.handle.net/1721.1/37957.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Biological Engineering Division, 2006.<br>Includes bibliographical references (p. 143-160).<br>Live or attenuated pathogens are the basis of many successful vaccines due in part to the orchestrated response of dendritic cells (DCs) triggered by these immunizations, which includes (1) DC and DC precursor attraction to the immunization site, (2) efficient antigen delivery to class I and class II MHC loading pathways coincident with maturation of DCs, and (3) emigration to draining lymph nodes for T cell activation. We have developed a model

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Barrera, Esequiel Eduardo. "Synthesis and characterization of oligonucleotides containing deoxyxanthosine : a probe for the mutagentic and genotoxic activity of an oxidized DNA base." Thesis, Massachusetts Institute of Technology, 1995. http://hdl.handle.net/1721.1/36650.

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Sharma, Ragahv. "Behavioral Modeling and FPGA Synthesis of IEEE 802.11n Orthogonal Frequency Division Multiplexing (OFDM) Scheme." Scholar Commons, 2016. http://scholarcommons.usf.edu/etd/6584.

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In the field of communications, a high data rate and low multi-path fading is required for efficient information exchange. Orthogonal Frequency Division Multiplexing (OFDM) is a widely accepted IEEE 802.11n (and many others) standard for usage in communication systems operating in fading dispersive channels. In this thesis, we modeled the OFDM algorithm at the behavioral level in VHDL/Verilog that was successfully synthesized/verified on an FPGA. Due to rapid technology scaling, FPGAs have become popular and are low-cost and high performance alternatives to (semi-) custom ASICs. Further, due t

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Fleurie, Aurore. "Rôle de la sérine-thréonine kinase StkP dans la division et la morphogenèse du pneumocoque." Thesis, Lyon 1, 2013. http://www.theses.fr/2013LYO10152.

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La bactérie Streptococcus pneumoniae peut provoquer de sérieuses pathologies chez l'homme telles que des pneumonies, méningites ou septicémies. L'étude de cette bactérie constitue donc un enjeu de santé publique international. Ces dernières années, il a été mis en évidence que les bactéries exprimaient des Sérine/Thréonine Protéine‐Kinases de type eucaryote (STPKs) et que ces dernières intervenaient dans la régulation de nombreux processus cellulaires. Une approche prometteuse serait donc de cibler les mécanismes de régulation contrôlés par les STPKs pour lutter contre les infections à pneumoc

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Chen, Patty P. 1981. "Lung tissue engineering : in vitro synthesis of lung tissue from neonatal and fetal rat lung cells cultured in a three-dimensional collagen matrix." Thesis, Massachusetts Institute of Technology, 2004. http://hdl.handle.net/1721.1/28758.

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Thesis (M. Eng.)--Harvard-MIT Division of Health Sciences and Technology, 2004.<br>Includes bibliographical references (p. 76-77).<br>The focus of this study was to investigate the histology of tissue formed when fetal (16-20 days gestation) and neonatal (2 days old) rat lung cells were grown in a collagen-glycosaminoglycan scaffold. This project employed a collagen-GAG scaffold specifically developed for tissue engineering and investigated the effect of this substratum on the formation of lung histotypic structures in vitro. A cell isolation procedure was developed whereby 19-days gestation t

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Zucchini, Laure. "Rôle du domaine extracellulaire de la sérine/thréonine-kinase StkP dans la division cellulaire et la morphogenèse du pneumocoque." Thesis, Lyon, 2017. http://www.theses.fr/2017LYSE1103.

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Streptococcus pneumoniae (ou pneumocoque) est un agent pathogène humain responsable de maladies invasives et potentiellement mortelles. Les mécanismes impliqués dans le processus d'invasion restent largement inconnus, mais plusieurs observations suggèrent que les processus de signalisation impliquant la phosphorylation des protéines participeraient au caractère invasif du pneumocoque. Le génome de S. pneumoniae code pour une seule tyrosine-kinase (CpsD) et une seule sérine/thréonine-kinase (StkP). Cette dernière serait notamment impliquée dans la virulence, la compétence et la division cellula

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Benevides, Norma. "Relation entre l'activité herbicide de quelques composés et leur liaison à des protéines ou à des structures membranaires isolées." Grenoble 1, 1987. http://www.theses.fr/1987GRE10143.

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Le travail presente dans ce memoire est une etude des relations pouvant exister entre l'activite de composes herbicides inhibiteurs de la division cellulaire chez les vegetaux et leur liaison a des proteines (tubuline, serum albumine bovine=sab) ou a des structures membranaires (thylakoides). Nous avons constitue une serie d'inhibiteurs connus de la division cellulaire (propyzamide, butraline, pentachlorophenol=pcp, colchicine et deux phenylcarbamates: prophame et chlorprophame=cipc). Nous avons verifie leur efficacite et compare celle-ci a l'activite de 19 pyridilcarbamates nouveaux (. . . )

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Richter, Raik. "Ein Beitrag zur Modellierung und Realisierung der direkten digitalen Frequenzsynthese." Doctoral thesis, [S.l. : s.n.], 1999. http://deposit.ddb.de/cgi-bin/dokserv?idn=963112023.

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Richter, Raik. "Ein Beitrag zur Modellierung und Realisierung der direkten digitalen Frequenzsynthese." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2000. http://nbn-resolving.de/urn:nbn:de:swb:14-994337562500-99246.

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In der Dissertationsschrift wird ein neuartiges Konzept der Realisierung der Direkten Digitalen Frequenzsynthese (DDS) vorgestellt. Ausgehend von der analysierten Literatur werden das Wirkprinzip eines Standard-DDS-Synthesizer analysiert und Möglichkeiten zur Aufwandsreduktion untersucht. Ein neuartiger Ansatz zur Realisierung einer vollständig digitalen DDS ergibt sich in der Anwendung der Pulse-Output-DDS. Bei der Pulse-Output-DDS wird neben dem D/A-Wandler auch die Sinus-ROM-Tabelle aus dem prinzipiellen Aufbau der Standard-DDS entfernt. Ausgehend von einer derart modifizierten DDS-Struktur

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Hsieh, Nien-Hua, and 謝念驊. "Synthetic research in the division of 《Da ming tong wen ji ju yao》." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/82069795860585931765.

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碩士<br>東吳大學<br>中國文學系<br>99<br>《Da ming tong wen ji ju yao》is a word book written by Tien Yi-Hen in Ming dynasty. Which is written before “Vocabulary”, has rarely been told in etymology books. Yet the editing method of this book is inherited by《Shuowen Jiezi》, and modified by the author's chronic reflection in Chinese words. That makes a great difference in the editing style between this book and traditional word book. The concepts of the division of rational words is also similar to the concepts of the edition and explanation of word books in Ching dynasty.Although it's not valued by the schola

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Hassan, E., P. Deshpande, F. Claeyssens, Stephen Rimmer, and S. MacNeil. "Amine functional hydrogels as selective substrates for corneal epithelialization." 2014. http://hdl.handle.net/10454/10459.

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No<br>The aim of this study was to develop a synthetic hydrogel to act as a corneal substitute capable of selectively supporting the adhesion and proliferation of limbal epithelial cells (LECs) while inhibiting growth of limbal fibroblasts. Deficiency of LECs causes conjunctival epithelial cells to move over the cornea, producing a thick scar pannus. Unilateral defects can be treated using LEC cultured from the unaffected eye, transplanting them to the affected cornea after scar tissue is removed. The underlying wound bed is often damaged, however, hence the need to develop a corneal inlay to

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Schweizer, Jakob. "Min-Protein Waves on Geometrically Structured Artificial Membranes." Doctoral thesis, 2012. https://tud.qucosa.de/id/qucosa%3A25597.

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Das stäbchenförmige Bakterium Escherichia coli teilt sich in zwei gleich große Tochterzellen. Dies ist nur möglich, wenn sich die Zelle in der Mitte teilt. Bei E. coli wird die Zellteilung durch den Zusammenschluss der FtsZ-Proteine an der Membran zum Z-Ring eingeleitet. Topologische Regulierung des Z-Ringes erfolgt durch räumlich-zeitliche Oszillationen von Min-Proteinen zwischen den beiden Zellpolen. MinC, MinD und MinE binden an und lösen sich von der Membran unter Hydrolyse von ATP und in antagonistischer Art und Weise, was zu einer alternierenden Ansammlung von MinC und MinD an den Zellpo

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Davidoff, Avri Nava. "Protein synthesis, cell division and cell death." Thesis, 1993. http://hdl.handle.net/10539/21756.

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A thesis submitted to the Faculty of Science, University of Witwatersrand, Johannesburg, South Africa, in fulfilment of the requirements for the Degree of Doctor of Philosophy, This thesis presented as a series of manuscripts 1993<br>In this study the morphologic, cytokinetic, biochemical, and molecu1w: consequences of low-dose continuous Puromycin-exposure were examined in HL-60 cells, and in a variety of malignant and non-malignant human and murine cell types. Puromycin (PM) is a composite of the amino nucleoside dimethyladenosine and tyrosine-o-methylether. Functionally it is an an

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Sullivan, Thomas Dermot. "Studies of globin gene expression in differentiating erythroid cells (1) the role of cell division rate on the differential expression of human [gamma] and [beta] globin genes; (2) the effect of messenger RNA stability and translational efficiency on the differential expression of human [gamma] and [beta] globin genes; (3) the role of protein synthesis factors in the loss of protein synthetic capacity during aging of mouse reticulocytes /." 1985. http://catalog.hathitrust.org/api/volumes/oclc/13366013.html.

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"Effects of cyclic-3'5'-adenosine monophosphate on dna synthesis and cell division (tapeworm, strobilization, serotonin)." Tulane University, 1985.

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DNA synthesis, as monitored by ('3)H-thymidine incorporation, in the germinative stem cells of juvenile Hymenolepis diminuta, appears to be negatively modulated by increases in cyclic-3'5'-adenosine monophosphate (cAMP). Among the endogenous substances which elevate cAMP levels in these worms is serotonin, a.k.a. 5-hydroxytryptamine (5HT). High concentrations of exogenous 5HT, or treating worms with reserpine which presumably induces a secretion of endogenous 5HT, similarly depresses DNA synthesis. These findings suggest that factors such as 5HT, which increase worm cAMP levels, may negatively

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Figueiredo, Joana Silva. "Design of strategies to prevent synthesis of S. pneumoniae capsular polysaccharide at the bacteria division septum." Master's thesis, 2012. http://hdl.handle.net/10451/10499.

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Tese de mestrado. Biologia (Biologia Molecular e Genética). Universidade de Lisboa, Faculdade de Ciências, 2012<br>Streptococcus pneumoniae is a common respiratory bacterial pathogen and a frequent cause of community-acquired pneumonia in developed countries. The genes encoding for the capsule polysaccharide (CPS), one of the most important virulence factors of these bacteria, are organized in an operon and in almost all the serotypes the two conserved Wzd and Wze proteins are expressed. Previous results suggest that if these two proteins cannot interact, forming a Wzd/Wze protein complex, pne

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Cishek, Dawn M. "Calcium buffer incorporation reversibly inhibits DNA synthesis, nuclear envelope breakdown, and cell division in transformed keratinocytes." 1996. https://scholarworks.umass.edu/dissertations/AAI9638947.

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Loss of regulation of cell cycle events mediated by changes in cytosolic Ca$\sp{2+}$ ion activity has been implicated in the progression of normal cells to neoplasia. In this study, the Ca$\sp{2+}$ buffer 5,5$\sp\prime$-difluoro 1,2-bis(2-aminophenoxy) ethane-N,N,N$\sp\prime N\sp\prime$-tetra-acetic acid (5,5$\sp\prime$-dfBAPTA, abbreviated "dfB") has been used to modulate cell division in transformed and primary mouse keratinocytes. Exogenous application, via the tetra(acetoxymethyl) ester ("AM"), of 18-20 $\mu$M dfB/AM to the growth media of transformed cells inhibits cell division and DNA s

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Chou, Po-Jung, and 周柏融. "Exact Synthesis of Full- and Half-Symmetric Rat-Race Ring Couplers with Impedance Transformation and Arbitrary Power Division." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/tf5bqz.

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博士<br>國立交通大學<br>電信工程研究所<br>106<br>This thesis proposes the full- and half-symmetric rat-race ring hybrids/couplers, in which the impedance transformation and arbitrary power division characteristics can be implemented. The impedance transformation property implies that the input and output port impedances can be different. The arbitrary power division property implies that the power ratio at two output ports can be arbitrary values. Because of the half-symmetry, the conventional even- and odd-mode partition and corresponding analysis method cannot be applied. Two signal-excitation methods are

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Fan, Li. "mTOR regulates Aurora A via enhancing protein stability." Thesis, 2014. http://hdl.handle.net/1805/4648.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>Mammalian target of rapamycin (mTOR) is a key regulator of protein synthesis. Dysregulation of mTOR signaling occurs in many human cancers and its inhibition causes arrest at the G1 cell cycle stage. However, mTOR’s impact on mitosis (M-phase) is less clear. Here, suppressing mTOR activity impacted the G2-M transition and reduced levels of M-phase kinase, Aurora A. mTOR inhibitors did not affect Aurora A mRNA levels. However, translational reporter constructs showed that mRNA containing a short, simple 5’-untranslated region (UTR), r

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