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Dissertations / Theses on the topic 'Synthetic estrogen'

Author: Grafiati

Published: 4 June 2021

Last updated: 7 February 2022

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1

Brummer, Tyson Peter Thomas. "Comparative Immunological Effects of a Natural Estrogen (17β-estradiol) versus a Pharmacologic Synthetic Estrogen (17α-ethinyl estradiol)". Thesis, Virginia Tech, 2007. http://hdl.handle.net/10919/34601.

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Exposure to exogenous estrogens such as synthetic 17α-ethinyl estradiol (EE) occurs via multiple sources (i.e. hormonal contraceptives, environmental contamination, hormone replacement therapy). The natural estrogen, 17β-estradiol (E2), is a well-studied immunomodulatory hormone at both environmental and pharmacologic levels. Conversely, little data exist regarding the immune effects of EE at either environmentally-relevant exposure levels or at pharmacological levels. Further, EE is delivered to patients in a clinical setting via different routes of exposure (e.g. subcutaneous or oral).

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2

Cops, Elisa Jane. "Mibolerone, a synthetic androgen, opposes estrogen signalling in breast cancer cells /." Cover title, title page and abstract only, 2003. http://web4.library.adelaide.edu.au/theses/09SB/09sbc7857.pdf.

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3

Bhat, Abhijit Suresh. "A. Synthesis and biochemical evaluation of estrogen analogs. ; B. Synthetic strategies for constructing benzopyrone combinatorial libraries /." The Ohio State University, 1999. http://rave.ohiolink.edu/etdc/view?acc_num=osu1488190595941695.

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4

Geminiani, Lorenzo. "Synthetic studies towards a new fulvestrant analogue." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2016. http://amslaurea.unibo.it/10004/.

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A study towards the synthesis of a new fulvestrant analogue with improved bioavailability was carried out. In this work a twelve-step synthetic route starting from β-estradiol was optimized and a palladium (Pd)-catalyzed endo-selective Heck reaction for the functionalization of an advanced intermediate was investigated.

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5

Brown, Nicole Chantae. "The mechanism of T cell dysfunction induced by Diethylstilbestrol." VCU Scholars Compass, 2005. http://scholarscompass.vcu.edu/etd/1321.

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Estrogens have the ability to alter the immune system. Diethylstilbestrol (DES), asynthetic estrogen, is known to have estrogenic activity and induce thymic alterations.We investigated the mechanism by which DES is able to alter T cells and thus theimmune system. First, we studied the effect of DES on mature T cells by using the T cellleukemia cell line, Jurkat. We found that DES treatment reduced cell viability andincreased apoptosis. Additionally, apoptosis was found to involve both death receptorand mitochondria1 pathways. Furthermore, estrogen receptor beta was found to beexpressed in thes

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6

Wabuyele, Simuli Lindah. "DEVELOPMENT OF LC-MS/MS METHODS FOR QUANTITATIVE ANALYSIS OF PLANT-DERIVED ANTICANCER AGENT AND SYNTHETIC ESTROGEN IN COMPLEX MATRICES." Cleveland State University / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=csu1400262843.

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7

Riman, Tomas. "An epidemiologic study of epithelial ovarian malignancies : with a focus on hormone-related factors /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-362-7/.

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8

Miguel, Mariana. "Efeito do hormônio sintético 17α-etinilestradiol no invertebrado aquático Daphnia magna (Crustacea, Cladocera)." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/18/18139/tde-31032016-101847/.

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Muitas substâncias descartadas no meio ambiente não são totalmente degradadas, podendo assim persistir no ambiente. Diversos compostos são continuamente introduzidos no ambiente podendo afetar a biota e inclusive o homem. Os fármacos são alguns desses compostos que depois de descartados podem chegar nos corpos de águas naturais, e dentre eles merecem especial atenção os hormônios sintéticos utilizados em larga escala por mulheres em todo o mundo, na forma de contraceptivos orais. O hormônio sintético 17α-etinilestradiol é um micropoluente no ambiente aquático, que pode causar distúrbios n

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9

Karolczak, Magdalena. "Estrogen synthesis and novel mechanisms of estrogen action in the developing brain." Ulm : Universität Ulm, Medizinische Fakultät, 2000. http://www.bsz-bw.de/cgi-bin/xvms.cgi?SWB9394023.

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10

Karolczak, Magdalena [Verfasser]. "Estrogen synthesis and novel mechanisms of estrogen action in the developing brain / Magdalena Karolczak." Ulm : Universität Ulm. Medizinische Fakultät, 2001. http://d-nb.info/1015473156/34.

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11

Da, Silva Paulo Alexandre Reis Chemistry Faculty of Science UNSW. "Development of synthetic approaches towards molecules with potential SERM activity." Awarded by:University of New South Wales. School of Chemistry, 2005. http://handle.unsw.edu.au/1959.4/22411.

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The primary aim of this project was to develop organometallic methodologies for the conversion of aryl benzyl ketones into aryl- and/or aroyl- substituted stilbenes related to Selective Estrogen Receptor Modulators (SERMs): Tamoxifen and Raloxifene, respectively. Consideration was given to target molecules that were acyclic, cyclic or heterocyclic. A secondary aim of the project was to develop methodologies that would allow combinatorial methods to be applied to the synthesis of these compounds, allowing quick access to a diverse range of SERM-candidate libraries of compounds. Primary methodol

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12

Talbi, Oussama. "Synthesis of Homo A-CD Estrogens for Potential Use in Hormone Replacement Therapy." Thesis, Université d'Ottawa / University of Ottawa, 2015. http://hdl.handle.net/10393/32082.

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Hormone replacement therapy (HRT) has been subject to much debate due to concerns that long term use of such treatment of menopause increases the risk of breast and uterine cancer. This is thought to be caused by estradiol (1) binding to the estrogen receptor α (ERα) resulting in increased cell proliferation. Another possible mechanism relates to toxicity of the estrodiol metabolites, which are thought to be genotoxic ortho-quinones. In a previous project, a series of A-CD estrogens (2) were synthesised as non-carcinogenic estradiol agonists where the cis CD ring junction was thought to be the

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13

Shan, Min [Verfasser]. "Design, synthesis, and evaluation of bivalent estrogen ligands / Min Shan." Berlin : Freie Universität Berlin, 2012. http://d-nb.info/102669552X/34.

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14

Tinder, Robert J. "Design, synthesis and docking models of estrogen and androgen receptor antagonists." Diss., Restricted to subscribing institutions, 2010. http://proquest.umi.com/pqdweb?did=2023832701&sid=1&Fmt=2&clientId=1564&RQT=309&VName=PQD.

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15

Perry, Heather N. "Synthesis of compounds capable of producing cytotoxic N3-methyladenine DNA adducts in estrogen receptor positive cells /." Electronic version (PDF), 2007. http://dl.uncw.edu/etd/2007-3/perryh/heatherperry.pdf.

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16

Malik, Neha. "Total Synthesis of Natural Product Pterocarpans Useful as Selective Estrogen Receptor Modulators." University of Toledo Health Science Campus / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=mco1384344530.

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17

Griffith, David R. (David Richmond). "Natural and synthetic estrogens in wastewater treatment plant effuent and the coastal ocean." Thesis, Massachusetts Institute of Technology, 2013. http://hdl.handle.net/1721.1/85824.

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Thesis: Ph. D., Joint Program in Oceanography/Applied Ocean Science and Engineering (Massachusetts Institute of Technology, Department of Civil and Environmental Engineering; and the Woods Hole Oceanographic Institution), 2013.<br>Pages 181 and 182 blank. Cataloged from PDF version of thesis.<br>Includes bibliographical references.<br>Steroidal estrogens are potent endocrine disrupting chemicals that are naturally excreted by vertebrates (e.g., humans and fish) and can enter natural waters through the discharge of treated and raw sewage. Because estrogens are detrimental to aquatic organisms a

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18

Lashley, Matthew Riley. "The synthesis of tamoxifen and 4-hydroxytamoxifen analogs for estrogen receptor-targeted applications /." For electronic version search Digital dissertations database. Restricted to UC campuses. Access is free to UC campus dissertations, 2003. http://uclibs.org/PID/11984.

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19

Tao, Menghua. "Genetic polymorphisms of estrogen synthesis and metabolic enzyme genes and endometrial cancer risk." Diss., Restricted to subscribing institutions, 2006. http://proquest.umi.com/pqdweb?did=1273105491&sid=1&Fmt=2&clientId=1564&RQT=309&VName=PQD.

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20

Stevens, Joan M. "The synthesis and biochemical evaluation of inhibitors of hepatic estrogen 2/4-hydroxylase /." The Ohio State University, 1988. http://rave.ohiolink.edu/etdc/view?acc_num=osu148759571215826.

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21

Lim, Laurie. "Efforts toward the design and synthesis of small molecule inhibitors of the estrogen receptor." Thesis, McGill University, 2012. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=106521.

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The investigation and development of small molecule inhibitors for the estrogen receptor is presented. Successful interpretation of its key protein-protein interactions with several coactivators is described using computational methods. Further examination using a known set of small molecule ligands failed to predict affinity for the receptor. It was determined that a computational assessment was unfeasible for the design of new ligands. The design and synthesis of SERM-HDACi (selective estrogen receptor modulator-histone deacetylase inhibitor) multiple ligands is described in detail. Multiple

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22

Lynch, Tera L. "Design and synthesis of DNA minor groove methylating compounds that target estrogen receptor positive cells /." Electronic version (PDF), 2006. http://dl.uncw.edu/etd/2006/lyncht/teralynch.pdf.

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23

Williams, Benjamin. "Design, synthesis and evaluation of selective estrogen receptor modulator/histone deacetylase inhibitor merged bifunctional ligands." Thesis, McGill University, 2014. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=123082.

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Breast cancer remains one of the most persistent threats to women's health in the Western world. The selective estrogen receptor modulator (SERM) tamoxifen is a front-line treatment for the disease, but suffers from a high rate of acquired resistance and an increased risk of endometrial cancer. As such, improved small molecule inhibitors with the ability to overcome antiestrogen resistance while limiting adverse side effects are valuable pharmaceutical targets. Histone deacetylase inhibitors (HDACi) have recently emerged as versatile anticancer agents with antiproliferative activity in breast

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24

Memminger, Martin. "Synthesis and characterization of subtype-selective estrogen receptor ligands and their application as pharmacological tools : cross-talk between estrogen and NPY Y1 receptors in human breast cancer cells." kostenfrei, 2009. http://www.opus-bayern.de/uni-regensburg/volltexte/2009/1215/.

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25

James, Karen Elizabeth. "Synthesis and biochemical evaluation of inhibitors of estrone sulfatase." Thesis, Kingston University, 2000. http://eprints.kingston.ac.uk/20650/.

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The use of enzyme inhibitors in the treatment of patents with hormone-dependant breast cancer is discussed. Particular emphasis is placed on the inhibition of the enzymes 17[beta]-hydroxysteroid dehydrogenase, aromatase, and estrone sulfatase. Novel inhibitors of estrone sulfatase have been designed, synthesised, and subsequently subjected to biochemical testing to assess their inhibitory activity. From this study a number of highly potent non-steroidal compounds have been identified which appear to be the most potent non-steroidal estrone sulfatase inhibitors known to date. Investigation into

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26

Kalita, Mausam. "Synthesis and labeling strategy for indirect detection of estrogen-derived DNA adducts using aqueous quantum dots." Diss., Kansas State University, 2010. http://hdl.handle.net/2097/7018.

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Doctor of Philosophy<br>Department of Chemistry<br>Stefan Bossmann<br>Estrogen-derived DNA adducts in human could be the initiating step of breast and prostate cancer, as the scientific literature suggests. Previous studies demonstrated that 4-hydroxy-estrone (estradiol)-1-N3Adenine and 4-hydroxy-estrone (estradiol)-1-N7Guanine were the most abundant adducts found in urine of human subjects. Sensitive detection of these adducts in urine samples could lead to better breast and prostate cancer risk assessment. The standard adducts were synthesized and characterized by NMR and mass spectrometry.

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27

Spetz, Anna-Clara. "Vasomotor symptoms in men and the role of calcitonin gene-related peptide /." Linköping : Univ, 2002. http://www.bibl.liu.se/liupubl/disp/disp2002/med758s.pdf.

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28

Cowing, Brandy Ellen. "Vitamin B6 Decreases Proliferation and DNA Synthesis in Human Mammary Carcinoma Cell Lines In Vitro." Thesis, Virginia Tech, 2000. http://hdl.handle.net/10919/31644.

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The growth of many breast cancers is stimulated by the action of the hormone estrogen. Hormonal therapy used to treat these estrogen-dependent breast cancers acts by interfering with the action of estrogen. Current treatments, such as tamoxifen, are not consistently useful due to development of resistance to these drugs. Tamoxifen treatment can also lead to the development of other gynecological cancers, therefore the discovery of novel treatment options for breast cancer is critical. Vitamin B6 is well documented for its role as a modulator of steroid hormones. Pyridoxal phosphate (PLP),

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29

Luniwal, Amarjit. "Design, Synthesis, and Process Chemistry Studies of Agents Having Anti-Cancer Properties." University of Toledo Health Science Campus / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=mco1302801948.

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30

Chkrebtii, Anna. "Synthesis of Non-Steroidal Estrogen Agonists for Hormone Replacement Therapy and Synthesis and Reactivity of 2,3-Substituted 5-Silyl-7-Oxa-Bicyclo[2.2.1]Heptenes and Heptadienes." Thesis, Université d'Ottawa / University of Ottawa, 2010. http://hdl.handle.net/10393/19750.

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The focus of the research described in this section of the thesis is the synthesis of compounds expected to bind strongly to both the estrogen β and α receptors and act as estrogen agonists. Based on earlier results in our group and docking studies we prepared a series of A-CD analogs, compounds 1, in which the usual 13-methyl group was replaced by an ethyl group. Docking studies also indicated that substituents at C8 could lead to enhancement of binding to the estrogen receptor. With this in mind two such derivatives, compounds 2 were prepared. A major concern in the use of estradiol in hormo

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31

Cyrus, Kedra C. "SYNTHESIS AND EVALUATION OF PROUTEOLYSIS TAURGETING CHIMERAS (PROTACs): A POTENTIAL CHEMICAL GENETIC APPROACH TO BREAST CANCER THERAPY." UKnowledge, 2009. http://uknowledge.uky.edu/gradschool_diss/773.

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The use of small molecules to probe the function of proteins is referred to as chemical genetics. The Proteolysis Targeting Chimera (PROTAC) is a chemical genetic tool that contains the ligand for a target protein of interest and the recognition motif for an E3 ubiquitin ligase attached by a linker. The PROTAC is capable of binding to and recruiting specific target proteins to the intracellular degradation system, the ubiquitin proteasome system (UPS). While the approach has had success it has not been optimized to be used on a broader scale. Optimization efforts focused on elucidating the ide

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32

Patel, Chirag K. "Synthesis and biochemical evaluation of inhibitors of estrone sulfatase as potential anti-tumour agents." Thesis, Kingston University, 2003. http://eprints.kingston.ac.uk/20718/.

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In the treatment of hormone-dependent breast cancer, extensive research has been undertaken to produce compounds, which are both potent and selective inhibitors of the cytochrome P-450 enzyme aromatase. However, the use of aromatase inhibitors does not result in the inhibition of all of the biosynthetic processes, which lead to estrogen formation. That is, the enzyme estrone sulfatase converts the stored (sulfated) form of the estrogens to the active (non-sulfated) forms, thereby allowing the stimulation of tumours via a non-aromatase pathway and which, in general, is not blocked by aromatase

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33

Aidoo-Gyamfi, K. "Synthesis of potential inhibitors of estrone sulfatase in the treatment of hormone-dependent breast cancer." Thesis, Kingston University, 2007. http://eprints.kingston.ac.uk/20435/.

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Estrone sulfatase (E 1 STS) belongs to a family of enzymes, namely the steroid sulfatases, which catalyse the conversion of the biologically inactive .cornpound to the more potent biologically active steroid. In particular, E1STS catalyses the conversion of estrone sulfate to estrone (E 1) and is therefore a pivotal enzyme in the progression of hormone-dependent breast cancer in postmenopausal women. The use of aromatase (AR) inhibitors, such as anastrozole, has led to the reduction of plasma levels of E1 by as much as 98%, however, it has been suggested that the high levels of E1 found within

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34

Choueiri, Christine. "Synthesis of A-CD Estrogens with Potential for Hormone Replacement Therapy. Isolation of Sesquiterpene Lactones from Neurolaena lobata and Diterpenoids from Leretia cordata." Thèse, Université d'Ottawa / University of Ottawa, 2013. http://hdl.handle.net/10393/26262.

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The use of estrogen supplements by postmenopausal women has been associated with increased risks of uterine and breast cancer. There are two possible mechanisms of toxicity: estradiol can promote breast cancer cell proliferation through estrogen receptor-α (ERα) and get metabolized to genotoxic ortho-quinones. The first part of this thesis describes the synthesis of a new series of non-carcinogenic A-CD estrogen agonists for hormone replacement therapy (HRT) with either the cis (1) or the trans (2) CD-ring junction. These compounds closely resemble estradiol (3) but lack the B-ring, allowin

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35

Dell\'Acqua, Marcelo Marques. "Efeito do hormônio 17α-etinilestradiol sobre a biologia de Chironomus sancticaroli (Chironomidae, Diptera)." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/18/18138/tde-09062017-152252/.

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A água constitui um dos compostos de maior distribuição e importância na crosta terrestre. Sua importância para vida está no fato de que nenhum processo metabólico ocorre sem a sua ação direta ou indireta. Entre os vários compostos contaminantes dos ambientes aquáticos, os hormônios, estrógenos naturais e sintéticos, devem ser vistos com uma maior importância, devido a sua persistência no ambiente. O 17α-etinilestradiol (EE2) é um hormônio sintético utilizado na formulação de contraceptivos orais, transdérmico e injetáveis. O presente estudo tem como objetivo analisar o efeito do hormônio

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36

Aleksandar, Oklješa. "Sinteza i biološka aktivnost novih steroidnih heterocikličnih jedinjenja." Phd thesis, Univerzitet u Novom Sadu, Prirodno-matematički fakultet u Novom Sadu, 2015. https://www.cris.uns.ac.rs/record.jsf?recordId=94966&source=NDLTD&language=en.

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U ovoj doktorskoj disertaciji ispitane su 1,3-dipolarnecikloadicione reakcije steroidnih azido-nitrila, nitrona initril-oksida, pri čemu su sintetizovana različitaheterociklična steroidna jedinjenja androstanske i estranskeserije. Utvrdjene su strukture novosintetizovanihjedinjenja. Ispitana je biolo&scaron;ka aktivnost odabranihjedinjenja.<br>In this PhD thesis 1,3-dipolar cycloadditions ofsteroidal azido-nitriles, nitrones and nitrile-oxide wereexamined. Various steroidal heterocyclic compounds inthe androstane and estrane series were synthesised. Thestructural characterisation of newly synt

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37

Jeantet, Meriella Anita. "In vitro progesterone and estrone synthesis by the porcine placenta and endometrium at 30, 60 and 90 days of gestation." Thesis, Virginia Polytechnic Institute and State University, 1985. http://hdl.handle.net/10919/91126.

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The present studies were conducted to gain a better understanding of the effects of pregnenolone (P₅), human chorionic gonadotropin (hCG) and 3' 5', cyclic adenosine monophosphate ( cAMP) on porcine placental and endometrial production of progesterone (P₄), testosterone (T) and estrone (E₁) at 30, 60 and 90 days of gestation. Duplicate 300 mg samples of placenta, endometrium or both (co-incubation) were incubated in medium199 containing either no P₅, P₅, P₅ + hCG or P₅ + cAMP for either zero (control), .5, 1 or 2 h. The first study compared P₄ and E₁ production with or without addition of P₅

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38

Bordbar, Hadi. "Synthesis of thiosemicarbazone-based and 3,5-dibromo-4-hydroxyphenyl ketone compounds as potential non-steroidal inhibitors of the enzyme estrone sulfatase." Thesis, Kingston University, 2011. http://eprints.kingston.ac.uk/22973/.

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Estrone sulfatase (STS) has been shown to play a major role in the biosynthesis of estrogens [in particular estrone (E 1) which subsequently leads to the biosynthesis of estradiol (E2)] and therefore the initiation and progression of hormone-dependent breast cancer in post menopausal women. Recently, a range of thiosemicarbazone-based compounds have been reported as inhibitors of STS, however, due to the mode of action of these inhibitors, no detailed structure-activity relationship (SAR) was offered. In an effort to investigate the SAR within the thiosemicarbazone-based compounds, the current

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39

Cartledge, Timothy. "Synthesis, biochemical evaluation and physiochemical property determination of a range of potential estrone sulfatase inhibitors in the treatment of hormone-dependent breast cancer." Thesis, Kingston University, 2008. http://eprints.kingston.ac.uk/20427/.

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The inhibition of enzymes within the steroidal cascade has been shown to lead to a reduction in tumour mass as a result of a reduction. in the levels of steroids present both within the plasma and within tumour cells. For example, 'in postmenopausal women, the use of enzyme inhibitors has led to the treatment of hormone-dependent breast cancer. Enzymes such as aromatase, 17ß-hydroxysteroid dehydrogenase [types 1 (17ß-HS01) and 3 (17ß-HS03)] and estrone sulfatase (ES) are some of the enzymes involved in the biosynthesis of steroids and have therefore become biochemical targets in the design and

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40

Suzana, Jovanović-Šanta. "Biološka aktivnost novosintetisanih D-seko i D-homo-estratrienskih derivata u in vivo i in vitro uslovima." Phd thesis, Univerzitet u Novom Sadu, Prirodno-matematički fakultet u Novom Sadu, 2010. http://dx.doi.org/10.2298/NS20101008JOVANOVICSANTA.

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Sintetisana su nova jedinjenja, 16- i 17-supstituisani 16,17-sekoestratrienski derivati i D-homoestranski derivati, polazeći od 3-benziloksi-17-hidroksi-16,17-sekoestra-1,3,5(10)-trien-16-nitrila. Ispitana je estrogena i antiestrogena aktivnost u eksperimentima <em>in vivo</em>, antiaromatazna aktivnost <em>in vitro</em>, antioksidantna aktivnost DPPH  i TBA testom, kao i antiproliferativna aktivnost prema ćelijskim linijama MCF-7 ATCC, MDA-MB-231, HT-29 i MRC-5 novosintetisanih jedinjenja.<br>Some new compounds, 16- and 17-substituted 16,17-secoest

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Islam, Kazi Mohammed Didarul. "Development of an orthogonal ligand-receptor pair based on synthetic estrogen analogs and engineered estrogen receptor for transcriptional regulation." Doctoral thesis, 2007. http://hdl.handle.net/11858/00-1735-0000-0006-B623-4.

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42

Nickels, Michael. "Synthetic approaches towards 2-fluoroestradiol : synthesis and evaluation of tacn-rhenium complexes as estrogen receptor imaging agents /." 2007. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3290334.

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Thesis (Ph. D.)--University of Illinois at Urbana-Champaign, 2007.<br>Source: Dissertation Abstracts International, Volume: 68-11, Section: B, page: 7349. Adviser: John A. Katzenellenbogen. Includes bibliographical references. Available on microfilm from Pro Quest Information and Learning.

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43

Islam, Kazi Mohammed Didarul [Verfasser]. "Development of an orthogonal ligand-receptor pair based on synthetic estrogen analogs and engineered estrogen receptor for transcriptional regulation / vorgelegt von Kazi Mohammed Didarul Islam." 2007. http://d-nb.info/984990798/34.

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44

Chen, Kuan-Wen, and 陳冠雯. "Gene Expression of Endocrine Disruption Related Genes by Co-Exposure of Conazole Fungicides and Synthetic Estrogen in Medaka Fish (Oryzias Latipes)." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/30568394815129126516.

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碩士<br>國立臺灣大學<br>農業化學研究所<br>99<br>Conazoles are a class of imidazole- or triazole-containing pesticides widely used in agricultural or medical field. Conazoles are environmentally-important fungicides that have received significant attention from regulatory agencies and scientists due to frequent occurrence in the aquatic environment. While all conazoles have anti-antifungal activity, some members of the conazole family have potential adverse effects in humans as they induce liver or thyroid tumors in rodents and cause endocrine disrupting effects in experimental animals. The objective of the s

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"Effect of genistein and 2,3,7,8-tetrachlorodibenzo-para-TCDD on aromatase activity." 2007. http://library.cuhk.edu.hk/record=b5896732.

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Chan, Ming Yan.<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 2007.<br>Includes bibliographical references (leaves 92-106).<br>Abstracts in English and Chinese.<br>ACKNOWLEDGEMENTS --- p.i<br>ABSTRACT --- p.ii<br>摘要 --- p.iv<br>LIST OF ABBREVIATIONS --- p.vi<br>TABLE OF CONTENTS --- p.viii<br>Chapter CHAPTER 1 --- GENERAL INTRODUCTION --- p.1<br>Chapter 1.1 --- Aromatase --- p.1<br>Chapter 1.2 --- Tissue Specific Promoter for Aromatase Expression --- p.4<br>Chapter 1.3 --- Signaling Pathway --- p.7<br>Chapter CHAPTER 2 --- MATERIALS AND METHODS --- p.9<br>Chapter 2.1 --- Chem

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46

"Effect of endocrine disruptors on the synthesis of estrogen and corticotrophin-releasing hormone in vitro and in vivo." Thesis, 2011. http://library.cuhk.edu.hk/record=b6075154.

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Huang, Hui.<br>Thesis (Ph.D.)--Chinese University of Hong Kong, 2011.<br>Includes bibliographical references (leaves 141-154).<br>Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web.<br>Abstract also in Chinese.

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Chi-YanTsai and 蔡奇諺. "Estrogen Functionalized Protein-Based Gold Nanoclusters - Synthesis, Characterization and Applications." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/09556088569244117017.

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碩士<br>國立成功大學<br>化學系<br>103<br>Protein-protected fluorescent gold nanoclusters (AuNCs) have attracted many attentions due to their superior properties such as low toxicity, high biocompatibility and feasible functionalization. In this study, bovine serum albumin-protected AuNCs (BSA-AuNCs) was synthesized and functionalized with 17β-estradiol-azide-poly(ethylene glycol) conjugates (E2-PEG) via carbodiimide crosslinker chemistry (EDC/NHS) and used to selectively target estrogen receptor positive breast cancer cell. E2-PEG derivative was synthesized from Ethinyl Estradiol (EE2) by CuI-assisted az

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"Structure function relationship study of Yuehchukene: a novel type non-oxygen estrogenic compound." Chinese University of Hong Kong, 1992. http://library.cuhk.edu.hk/record=b5895749.

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Dan Dan Ho.<br>Thesis (Ph.D.)--Chinese University of Hong Kong, 1992.<br>Includes bibliographical references (leaves 134-144).<br>Chapter Chapter One --- Introduction --- p.1<br>Chapter 1.1 --- Phytochemistry and Phylogeny --- p.1<br>Chapter 1.2 --- Biological Activity --- p.9<br>Chapter 1.3 --- Synthetic Estrogens and Anti-Estrogens --- p.14<br>Chapter 1.4 --- Estrogen Receptor and Anti-Estrogen Binding Site --- p.19<br>Chapter 1.5 --- Multiple and dissociated Biological Activity --- p.28<br>Chapter 1.6 --- A Future Role for Yuehchukene --- p.30<br>Chapter Chapter Two --- Materials and

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ZHUO, GUI-MEI, and 卓貴美. "Effects of estrogen on progesterone receptor synthesis during endometrial cell culture." Thesis, 1988. http://ndltd.ncl.edu.tw/handle/14876440363911154272.

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Mann, Meagan K. "Synthesis of non-steroidal estrogen receptor proteolysis targeting chimeric molecules (PROTACS) /." 2008. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3337858.

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Thesis (Ph. D.)--University of Illinois at Urbana-Champaign, 2008.<br>Source: Dissertation Abstracts International, Volume: 69-11, Section: B, page: 6816. Adviser: John Katzenellenbogen. Includes bibliographical references. Available on microfilm from Pro Quest Information and Learning.

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