Log in

Relevant bibliographies by topics / Synthetic ketone / Journal articles

To see the other types of publications on this topic, follow the link: Synthetic ketone.

Journal articles on the topic 'Synthetic ketone'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 journal articles for your research on the topic 'Synthetic ketone.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

Matsuo, Yutaka, and Hao-Sheng Lin. "(Invited) Evaporable Fullerene-Fused Ketone Via One-Step Direct Oxidation of Alkoxy to Ketone: Fullerene As a Redox Active Pendant." ECS Meeting Abstracts MA2022-01, no. 11 (2022): 812. http://dx.doi.org/10.1149/ma2022-0111812mtgabs.

Full text

Abstract:

We developed a direct oxidation reaction from a methoxy group to a keto group using a mild oxidizing agent with the aid of an oxidizable fullerene pendant. By using this key reaction, we developed a fullerene derivative that is stable even at high temperatures of 400 deg-C or higher and can be used for vacuum deposition to make thin films in organic electronic devices. A highly efficient CuBr2 promoted one-step direct oxidation of alkoxy indano[60]fullerenes to [60]fullerene-fused ketones is showcased. It is shown that the fullerene can behave as an electron-pool controlling the electron trans

APA, Harvard, Vancouver, ISO, and other styles

2

Murarka, Sandip, and Andrey Antonchick. "Metal-Catalyzed Oxidative Coupling of Ketones and Ketone Enolates." Synthesis 50, no. 11 (2018): 2150–62. http://dx.doi.org/10.1055/s-0037-1609715.

Full text

Abstract:

Recent years have witnessed a significant advancement in the field of radical oxidative coupling of ketones towards the synthesis of highly useful synthetic building blocks, such as 1,4-dicarbonyl compounds, and biologically important heterocyclic and carbocyclic compounds. Besides oxidative homo- and cross-coupling of enolates, other powerful methods involving direct C(sp3)–H functionalizations of ketones have emerged towards the synthesis of 1,4-dicarbonyl compounds. Moreover, direct α-C–H functionalization of ketones has also allowed an efficient access to carbocycles and heterocycles. Thi

APA, Harvard, Vancouver, ISO, and other styles

3

Mamedova, N., and N. Nabiyeva. "SYNTHESIS AND STUDY OF PROPERTIES OF DERIVATIVES OF NATURAL AND SYNTHETIC PETROLEUM ACIDS." Znanstvena misel journal, no. 89 (April 23, 2024): 22–26. https://doi.org/10.5281/zenodo.11049281.

Full text

Abstract:

Among the derivatives of natural and synthetic petroleum acids, esters are one of those that have the greatest practical importance. In this article, ketoesters of natural and synthetic petroleum acids were obtained and their properties were studied. The structure of the obtained ketoesters was confirmed with the help of IR – spectral analysis. Due to the low freezing point of ketoesters obtained on the basis of vinyl ketones of natural and synthetic petroleum acids, they were used as a depressant additive in diesel fuels. It was found that when adding 0.2% esters of methoxyethyl ketone

APA, Harvard, Vancouver, ISO, and other styles

4

ROMAN, Gheorghe. "Novel aminobenzenesulfonamides as potential inhibitors of carbonic anhydrases." Revue Roumaine de Chimie 69, no. 3-4 (2024): 111–17. http://dx.doi.org/10.33224/rrch.2024.69.3-4.01.

Full text

Abstract:

A synthetic approach to N-[3-(hetero)aryl-3-oxoprop-1-yl]sulfonamides by N-alkylation of sulfanilamide with structurally diverse ketone Mannich base hydrochlorides is being reported. This scarcely explored synthetic strategy that involves aminomethylated ketones as starting materials has afforded novel compounds, potentially useful as inhibitors of carbonic anhydrases, with moderate to good yields.

APA, Harvard, Vancouver, ISO, and other styles

5

Benz, Scott, та Andrew S. Murkin. "α-Ketol and α-iminol rearrangements in synthetic organic and biosynthetic reactions". Beilstein Journal of Organic Chemistry 17 (15 жовтня 2021): 2570–84. http://dx.doi.org/10.3762/bjoc.17.172.

Full text

Abstract:

In the presence of a suitable acid or base, α-hydroxyaldehydes, ketones, and imines can undergo isomerization that features the 1,2-shift of an alkyl or aryl group. In the process, the hydroxy group is converted to a carbonyl and the aldehyde/ketone or imine is converted to an alcohol or amine. Such α-ketol/α-iminol rearrangements are used in a wide variety of synthetic applications including asymmetric synthesis, tandem reactions, and the total synthesis and biosynthesis of natural products. This review explores the use of α-ketol rearrangements in these contexts over the past two decades.

APA, Harvard, Vancouver, ISO, and other styles

6

Zhao, Peng, Jie Min Liu, and Shi Chuan Tang. "The Interaction of Mixing Odorants with Similar Chemical Properties: A Case Study on Ketone Compounds." Advanced Materials Research 850-851 (December 2013): 32–37. http://dx.doi.org/10.4028/www.scientific.net/amr.850-851.32.

Full text

Abstract:

To investigate more about the interaction of mixing odorants, a series of sensory tests were conducted using five ketones [butanone (Bu), 2-Pentanone (Pe), 2-Hexanone (Hex), 2-Heptanone (Hep), 2-Octanone (Oc)] at varying concentration levels. The determination of odor threshold (OT) was initially conducted by the triangle odor bag method (GB/T 14675, China). The odor activity values (OAVs) of individual odorants at a wide range of concentrations were derived from concentration-to-odor threshold ratios. The resulting data were then evaluated to define the empirical relationship for each ketone

APA, Harvard, Vancouver, ISO, and other styles

7

Fu, Jiayue, Bingbing Li, Zefang Zhou, Maosheng Cheng, Lu Yang, and Yongxiang Liu. "Formal total synthesis of macarpine via a Au(I)-catalyzed 6-endo-dig cycloisomerization strategy." Beilstein Journal of Organic Chemistry 18 (November 23, 2022): 1589–95. http://dx.doi.org/10.3762/bjoc.18.169.

Full text

Abstract:

The formal total synthesis of macarpine was accomplished by the construction of a naphthol intermediate in Ishikawa’s synthetic route with two different synthetic routes. The convergent synthetic strategies feature the utilization of Au(I)-catalyzed cycloisomerizations of a 1,5-enyne and alkynyl ketone substrates, which were prepared by Sonogashira coupling reactions.

APA, Harvard, Vancouver, ISO, and other styles

8

Song, J. H., S. M. Bae, E. J. Lee, J. H. Cho, and D. I. Jung. "Formation of Benzodiazepines and Pyrazinylquinoxalines from Aromatic and Heteroaromatic Ketones via Deoximation." Asian Journal of Chemistry 32, no. 7 (2020): 1676–80. http://dx.doi.org/10.14233/ajchem.2020.22639.

Full text

Abstract:

The report stated that the treatment of o-phenylenediamine with acetone dicarboxylic acid, acetone and acetophenone afforded 2,4,4-trimethyl-3H-5-hydro-1,5-benzodiazepine. However, direct reactions of o-phenylenediamine with oximes (acetone oxime, acetophenone oxime, and benzophenone oxime) as ketone equivalents did not occur. In the course of present investigations, it is found that dichloroamine-T can be an efficient reagent for the conversion of oximes into the corresponding carbonyl compounds. As a part of a research program related to the synthetic study of pharmacologically interesting b

APA, Harvard, Vancouver, ISO, and other styles

9

Chun, Stephanie W., та Alison R. H. Narayan. "Biocatalytic Synthesis of α-Amino Ketones". Synlett 30, № 11 (2019): 1269–74. http://dx.doi.org/10.1055/s-0037-1611755.

Full text

Abstract:

Stereospecific generation of α-amino ketones from common α-amino acids is difficult to achieve, often employing superstoichiometric alkylating reagents and requiring multiple protecting group manipulations. In contrast, the α-oxoamine synthase protein family performs this transformation stereospecifically in a single step without the need for protecting groups. Herein, we detail the characterization of the 8-amino-7-oxononanoate synthase (AONS) domain of the four-domain polyketide-like synthase SxtA, which natively mediates the formation of the ethyl ketone derivative of arginine. The function

APA, Harvard, Vancouver, ISO, and other styles

10

Brown, RFC, and AJ Robinson. "A Synthetic Approach to (±)-Tridentoquinone." Australian Journal of Chemistry 48, no. 3 (1995): 515. http://dx.doi.org/10.1071/ch9950515.

Full text

Abstract:

Synthesis of the ansa-bridged benzofuranquinone (�)- tridentoquinone (�)-(1) is approached by construction of a C4 methyl ketone chain at the 3-position of 6-bromo-4,5,7-trimethoxy-2,2-dimethyl-2,3-dihydrobenzofuran (10) and alkylation at its 6-position leading after modification to a dimethyl C10 aldehydic chain. Closure of the ansa bridge by McMurry coupling of the aldehyde and ketone groups of the intermediate (33) with C8K/TiCl3 appears to occur, but in poor yield and with uncertain stereochemistry, and the synthesis has not been completed.

APA, Harvard, Vancouver, ISO, and other styles

11

Citarella, Andrea, and Nicola Micale. "Peptidyl Fluoromethyl Ketones and Their Applications in Medicinal Chemistry." Molecules 25, no. 17 (2020): 4031. http://dx.doi.org/10.3390/molecules25174031.

Full text

Abstract:

Peptidyl fluoromethyl ketones occupy a pivotal role in the current scenario of synthetic chemistry, thanks to their numerous applications as inhibitors of hydrolytic enzymes. The insertion of one or more fluorine atoms adjacent to a C-terminal ketone moiety greatly modifies the physicochemical properties of the overall substrate, especially by increasing the reactivity of this functionalized carbonyl group toward nucleophiles. The main application of these peptidyl α-fluorinated ketones in medicinal chemistry relies in their ability to strongly and selectively inhibit serine and cysteine prote

APA, Harvard, Vancouver, ISO, and other styles

12

Liu, Qingyin, Li Han, Bing Qin та ін. "Total synthesis of (±)-(1β,4β,4aβ,8aα)-4,8a-dimethyl-octahydro-naphthalene-1,4a(2H)-diol". Organic Chemistry Frontiers 5, № 10 (2018): 1719–23. http://dx.doi.org/10.1039/c8qo00225h.

Full text

Abstract:

The first total synthesis of (±)-(1β,4β,4aβ,8aα)-4,8a-dimethylocta-hydronaphthalene-1,4a(2H)-diol (1), a degraded sesquiterpene isolated from a fermentation broth of Streptomyces albolongus, has been achieved via three different synthetic approaches (13–15 steps) starting from racemic Wieland–Miescher ketone (2).

APA, Harvard, Vancouver, ISO, and other styles

13

González, Patricia Camarero, Sergio Rossi, Miguel Sanz, Francesca Vasile, and Maurizio Benaglia. "Synthesis of Tetrasubstituted Nitroalkenes and Preliminary Studies of Their Enantioselective Organocatalytic Reduction." Molecules 28, no. 7 (2023): 3156. http://dx.doi.org/10.3390/molecules28073156.

Full text

Abstract:

Starting from commercially available ketones, a reproducible and reliable strategy for the synthesis of tetrasubstituted nitroalkenes was successfully developed, using a two-step procedure; the HWE olefination of the ketone to form the corresponding α,β-unsaturated esters is followed by a nitration reaction to introduce the nitro group in the α position of the ester group. The enantioselective organocatalytic reduction of these compounds has also been preliminarily studied, to access the functionalized enantioenriched nitroalkanes, which are useful starting materials for further synthetic elab

APA, Harvard, Vancouver, ISO, and other styles

14

Gangadhar, Pamarthi, Sayini Ramakrishna, Ponneri Venkateswarlu, and Pabbaraja Srihari. "Stereoselective total synthesis and structural revision of the diacetylenic diol natural products strongylodiols H and I." Beilstein Journal of Organic Chemistry 14 (September 4, 2018): 2313–20. http://dx.doi.org/10.3762/bjoc.14.206.

Full text

Abstract:

The stereoselective total synthesis of strongylodiol H and I has been accomplished. The synthetic procedure comprised the stereoselective reduction of a ketone functionality in an ene–yne–one employing CBS as a catalyst and a Cadiot–Chodkiewicz coupling reaction as the key reaction steps. A common aldehyde intermediate has been used for the synthesis of both strongylodiols.

APA, Harvard, Vancouver, ISO, and other styles

15

Mori, Naoki. "Formal Synthesis of Pseudolaric Acid B." Synlett 31, no. 09 (2020): 907–10. http://dx.doi.org/10.1055/s-0039-1690829.

Full text

Abstract:

A formal synthesis of pseudolaric acid B, a diterpene isolated from the root bark of Pseudolarix kaempferi Gordon (Pinaceae), to Trost’s synthetic intermediate was achieved in 17 steps from a known ketone. Key features of this synthesis include a Claisen rearrangement and iodoetherification to construct quaternary stereocenters and ring-closing metathesis to form the seven-membered ring.

APA, Harvard, Vancouver, ISO, and other styles

16

Basdevant, Benoit, Audrey-Anne Guilbault, Samuel Beaulieu, Antoine Jobin-Des Lauriers та Claude Y. Legault. "Iodine(III)-mediated synthesis of chiral α-substituted ketones: recent advances and mechanistic insights". Pure and Applied Chemistry 89, № 6 (2017): 781–89. http://dx.doi.org/10.1515/pac-2016-1212.

Full text

Abstract:

AbstractThe development of iodine(III)-mediated synthetic transformations has received growing interest, in particular to mediate enantioselective processes. In this class, the α-tosyloxylation of ketone derivatives using iodine(III) is a particularly powerful one, as it yields α-tosyloxy ketones – versatile chiral precursors that enable rapid access to numerous α-chiral ketones through nucleophilic displacement. Despite years of research from numerous groups, the enantioselectivities for this transformation have remained modest. Using quantum chemical calculations, we have uncovered a possibl

APA, Harvard, Vancouver, ISO, and other styles

17

Thomas, Joice, Wim Dehaen, and Tomas Opsomer. "Chemoselectivity in the Synthesis of 1,2,3-Triazoles from Enolizable Ketones, Primary Alkylamines, and 4-Nitrophenyl Azide." Synthesis 49, no. 18 (2017): 4191–98. http://dx.doi.org/10.1055/s-0036-1588856.

Full text

Abstract:

In recent years, several organocatalytic/metal-free synthetic pathways towards 1,2,3-triazoles have been reported. One of them is a general metal-free route towards the synthesis of 1,5-di- or fully-substituted 1,2,3-triazoles, designed by our group and named the ‘triazolization’ reaction of ketones. Limitations of this route were encountered in reactions with more activated ketones, where the corresponding 1-(4-nitrophenyl)-1,2,3-triazole was found back as the major product. Interestingly, three different triazoles are formed when 1,3-diphenylacetone is used as the ketone. In the present work

APA, Harvard, Vancouver, ISO, and other styles

18

Klinchan, Chayada, Rattiya Namngam, Anek Sitsongkham, and Pitak Chuawong. "Synthesis and Study of Naphthoquinones Derivatives." Applied Mechanics and Materials 855 (October 2016): 26–30. http://dx.doi.org/10.4028/www.scientific.net/amm.855.26.

Full text

Abstract:

In this research, we reported the study and synthesis of naphthoquinones intermediate compounds lead to the target naphthoquinones derivatives product. Naphthoquinones derivatives have long been known to display anticancer and antimalarial activity in addition to a wide variety of other bioactivities. Moreover, it has been reported to possess antimalarial disease against Plasmodium falciparum. The naphthoquinones derivatives product (5) were synthesized by coupling with 2-(3-bromo-2,2-dimethylpropyl)-1-methoxynaphthalene (4) and methyl ketone fatty acid (3). The 2-(3-bromo-2,2-dimethylpropyl)-

APA, Harvard, Vancouver, ISO, and other styles

19

Dong, Linhan, Qinglong Meng, Carlos Ramírez-Palacios, Hein J. Wijma, Siewert J. Marrink та Dick B. Janssen. "Asymmetric Synthesis of Optically Pure Aliphatic Amines with an Engineered Robust ω-Transaminase". Catalysts 10, № 11 (2020): 1310. http://dx.doi.org/10.3390/catal10111310.

Full text

Abstract:

The production of chiral amines by transaminase-catalyzed amination of ketones is an important application of biocatalysis in synthetic chemistry. It requires transaminases that show high enantioselectivity in asymmetric conversion of the ketone precursors. A robust derivative of ω-transaminase from Pseudomonasjessenii (PjTA-R6) that naturally acts on aliphatic substrates was constructed previously by our group. Here, we explore the catalytic potential of this thermostable enzyme for the synthesis of optically pure aliphatic amines and compare it to the well-studied transaminases from Vibrio f

APA, Harvard, Vancouver, ISO, and other styles

20

Vierfond, J. M., A. Reynet, H. Moskowitz, and C. Thal. "New Synthetic Route to Pummerer's Ketone." Synthetic Communications 22, no. 12 (1992): 1783–92. http://dx.doi.org/10.1080/00397919208020498.

Full text

APA, Harvard, Vancouver, ISO, and other styles

21

Suzuki, Eiichi, Satoshi Idemura, and Yoshio Ono. "Methylvinyl Ketone Formation over Synthetic Chrysotile." Chemistry Letters 16, no. 9 (1987): 1843–46. http://dx.doi.org/10.1246/cl.1987.1843.

Full text

APA, Harvard, Vancouver, ISO, and other styles

22

Hagiwara, Hisahiro. "Aspects in the Total Syntheses of Higher Terpenoids Starting From Wieland–Miescher Ketone and Its Derivative: A Review." Natural Product Communications 15, no. 5 (2020): 1934578X2092534. http://dx.doi.org/10.1177/1934578x20925340.

Full text

APA, Harvard, Vancouver, ISO, and other styles

23

Deslongchamps, Pierre, André Bélanger, Daniel J. F. Berney, et al. "The total synthesis of (+)-ryanodol. Part I. General strategy and search for a convenient diene for the construction of a key tricyclic intermediate." Canadian Journal of Chemistry 68, no. 1 (1990): 115–26. http://dx.doi.org/10.1139/v90-021.

Full text

Abstract:

This paper reports a retrosynthetic analysis that led to the conception of a synthetic strategy for the construction of ryanodol (2). The preparation of a key diene, i.e., spirolactone dienone 47 (19 → 31 → 33 → 48 → 49 → 52 → 47), and its Diels–Alder reaction with methyl vinyl ketone are reported. Keywords: strategy, synthesis, ryanodol, diterpene.

APA, Harvard, Vancouver, ISO, and other styles

24

Black, C., P. Lario, A. P. Masters, T. S. Sorensen, and F. Sun. "A new synthesis of in situ cyclopropanones and the observation of a thermal cyclopropanone–dienol rearrangement." Canadian Journal of Chemistry 71, no. 11 (1993): 1910–18. http://dx.doi.org/10.1139/v93-238.

Full text

Abstract:

A new in situ low-temperature synthesis of cyclopropanones from α,α′-dibromo ketones is described. The synthetic procedure is particularly well suited to NMR tube-scale experiments, which then easily allows one to spectroscopically characterize low-temperature solutions of these unstable molecules. Nine systems were studied, seven of which give high yields of the cyclopropanones at −78 °C or, in one case, −93 °C. The major rearrangement pathway of these cyclopropanones leads to an α,β-unsaturated ketone. The mechanism of this reaction has been studied in some detail, including deuterium isotop

APA, Harvard, Vancouver, ISO, and other styles

25

Castagnolo, Daniele, and Kate Lauder. "Photo-Biocatalytic Cascades for the Synthesis of Volatile Sulfur Compounds and Chemical Building Blocks." Synlett 31, no. 08 (2020): 737–44. http://dx.doi.org/10.1055/s-0039-1690784.

Full text

Abstract:

Biocatalysis is a branch of catalysis that exploits enzymes to perform highly stereoselective chemical transformations under mild and sustainable conditions. This Synpact highlights how biocatalysis can be used in the synthesis of chiral 1,3-mercaptoalkanols, an important class of compounds responsible for the flavours and aromas of many foods and beverages. The identification of two ketoreductase (KRED) enzymes able to reduce prochiral ketone precursors enantioselectively to 1,3-mercaptoalkanols bearing a C–O stereocentre is presented. In addition, the combination of a photocatalytic thia-Mic

APA, Harvard, Vancouver, ISO, and other styles

26

Wang, Wan Lin, and Jian Gong Shi. "Application Study of AlCl₃/Al Catalyst in Fridel-Crafts Acylation Reaction." Advanced Materials Research 233-235 (May 2011): 1097–99. http://dx.doi.org/10.4028/www.scientific.net/amr.233-235.1097.

Full text

Abstract:

The traditional AlCl3 catalyst was substituted by a new-type solid acidic catalyst AlCl3/Al for the synthetic reaction of Fridel-Craft acylation from benzene and benzoyl chloride to diphenyl ketone. It has been showed that the yield of diphenyl ketone rising from 55% to 66%, hydrogen chloride emissions decreasing by 70.8%, and the new one being an environmental friendly catalyst.

APA, Harvard, Vancouver, ISO, and other styles

27

Milokhov, Demyd S., Vasyl Y. Hys, Olesya B. Volovenko, Irina S. Konovalova, Svitlana V. Shishkina, and Yulian M. Volovenko. "Synthetic Approach to Fused Azasultams with 1,2,4-Thiadiazepine Framework." Synthesis 52, no. 19 (2020): 2857–69. http://dx.doi.org/10.1055/s-0040-1707405.

Full text

Abstract:

Synthetic approach to fused azasultams with 1,2,4-thiadiazepine framework via base promoted protocols has been developed. 1H-Azole-2-carboxylates and N-(chloromethyl)-N-methylmethanesulfonamide were used as ambiphilic building blocks in the one-pot and two-step reaction sequences. Chemical behavior of the obtained azasultams in reactions with amines, hydrazine, DMFDMA, and NaBH4 was investigated. An enamino ketone derived from an azasultam was exploited in the synthesis of new pyrazole and pyrimidine heterocycles.

APA, Harvard, Vancouver, ISO, and other styles

28

Mohammad, Asif. "A review on recent advances and potential pharmacological activities of versatile chalchone molecule." Chemistry International 2, no. 1 (2016): 1–18. https://doi.org/10.5281/zenodo.1470521.

Full text

Abstract:

Chalchone is an aromatic ketone and precursors of open chain flavonoids and isoflavonoids present in edible plants and their derivatives have attracted attention due to many potential pharmacological activities. Chalchone are also known as benzalacetophenone and phenyl styryl ketone. Modifications in their structure have offered diverse pharmacological activities that have proven useful for the development of new medicinal agents having improved potency and lesser toxicity. They are also the intermediates in the Auwer's synthesis of flavanoids and in the biosynthesis of flavanoids. Chalcho

APA, Harvard, Vancouver, ISO, and other styles

29

Ma, Jinyi, Aqun Zheng, Qin Pan, et al. "The Synthesis of Sn-Containing Silicates Coated with Binaphthol and Their Specific Application for Catalytic Synthesis of 6-Hydroxyhexanoic Acid and Cyclohexylformate through Baeyer-Villiger Oxidation." Catalysts 13, no. 5 (2023): 805. http://dx.doi.org/10.3390/catal13050805.

Full text

Abstract:

The Baeyer–Villiger oxidation (BVO) of ketone and aldehyde can produce ester and formate, which both have wide applications in many areas. In this work, a series of Sn-containing silicates were prepared through the sol-gel process by using structure-directing and crystallizing agents and post-synthetic coordinated modification of binaphthol. Characterizations revealed that loading of (L)-sodium lactate as the crystallizing agent decreased the crystal size of the synthesized catalyst, and there were SnO2 nanoparticles with sizes of 17–19 nm on the catalyst. Furthermore, quite differently from t

APA, Harvard, Vancouver, ISO, and other styles

30

Ryabukhin, Sergey, Kostiantyn Melnykov, Dmitriy Granat, Dmitriy Volochnyuk, and Oleksandr Grygorenko. "Multigram Synthesis of C4/C5 3,3-Difluorocyclobutyl-Substituted Building Blocks." Synthesis 50, no. 24 (2018): 4949–57. http://dx.doi.org/10.1055/s-0037-1610237.

Full text

Abstract:

An approach for the multigram synthesis of 3,3-difluorocyclobutyl-substituted building blocks (including carboxylic acid, amines, alcohols, azide, trifluoroborate ketone) is described. It is shown that, in most cases, ethyl 3,3-difluorocyclobutanecarboxylate is a convenient common synthetic intermediate to obtain the target derivatives. For preparation of 3,3-difluorocyclobutanol or -cyclobutanone, an alternative pathway via reaction of dichloroketene and tert-butyl or benzyl vinyl ether should be applied.

APA, Harvard, Vancouver, ISO, and other styles

31

Singh, Nidhi, and Jaya Pandey. "One-Pot, Water-Mediated, H2O2-HCl Catalyzed Synthesis of Benzazepines." Asian Journal of Chemistry 32, no. 5 (2020): 1165–68. http://dx.doi.org/10.14233/ajchem.2020.22574.

Full text

Abstract:

One-pot, multicomponent H2O2-HCl catalyzed system was employed for the synthesis of a series of benzazepine compounds. The implemented procedure oxidized the carbon-nitrogen bonds and produced benzazepines, while integrating diamines and substituted ketone. The advantage of the exercised synthetic route was that the reaction was water mediated and the completion time was quite reduced compared to the time required by conventional methods

APA, Harvard, Vancouver, ISO, and other styles

32

Ascenso, Osvaldo S., Gonzalo Carrau, Karina B. Xavier, M. Rita Ventura, and Christopher D. Maycock. "An Efficient Synthesis of Optically Active [4-13C] Labelled Quorum Sensing Signal Autoinducer-2." Molecules 26, no. 2 (2021): 369. http://dx.doi.org/10.3390/molecules26020369.

Full text

Abstract:

A new synthetic route for the quorum sensing signal Autoinducer-2 (AI-2) is described and used for the preparation of [4-13C]-AI-2 starting from [1-13C]-bromoacetic acid. The key step in this process was the enantioselective reduction of an intermediate ketone. This synthesis provides, selectively, both enantiomers of the labelled or unlabelled parent compound, (R) or (S)-4,5-dihydroxypentane-2,3-dione (DPD) and was used for an improved synthesis of [1-13C]-AI-2.

APA, Harvard, Vancouver, ISO, and other styles

33

Ablott, Timothy A., Shane G. Telfer, and Christopher Richardson. "A post-synthetically reduced borane-functionalised metal–organic framework with oxidation-inhibiting reactivity." CrystEngComm 22, no. 32 (2020): 5289–95. http://dx.doi.org/10.1039/d0ce00930j.

Full text

APA, Harvard, Vancouver, ISO, and other styles

34

Sow, Boubacar, Gabriel Bellavance, Francis Barabé, and Louis Barriault. "One-pot Diels–Alder cycloaddition/gold(I)-catalyzed 6-endo-dig cyclization for the synthesis of the complex bicyclo[3.3.1]alkenone framework." Beilstein Journal of Organic Chemistry 7 (July 22, 2011): 1007–13. http://dx.doi.org/10.3762/bjoc.7.114.

Full text

Abstract:

The rapid synthesis of bicyclo[m.n.1]alkanone cores possessing quaternary carbon centers adjacent to a bridged ketone represents a significant synthetic challenge. This type of architectural feature is embedded in various complex biologically active compounds such as hyperforin and garsubellin A. Herein, we report a highly diastereoselective one-pot Diels–Alder reaction/Au(I)-catalyzed carbocyclization to generate bicyclo[3.3.1]alkanones in yields ranging from 48–93%.

APA, Harvard, Vancouver, ISO, and other styles

35

Lin, Jin, Jing Fen Li, Bin Bin Zheng, Xiao Ting Dai, Jia Feng, and Ting Ting Yu. "Efficient Synthesis of 3,4-Dihydropyrimidin-2(1H)-Ketone Using SbCl₃ as Catalyst under Ultrasonic Conditions." Applied Mechanics and Materials 316-317 (April 2013): 1045–48. http://dx.doi.org/10.4028/www.scientific.net/amm.316-317.1045.

Full text

Abstract:

In this study, SbCl3 as catalyst to benzaldehyde, ethyl acetoacetate and urea as raw material in the ultrasonic radiation synthesis of 3,4-Dihydropyrimidin-2(1H)-ketone. According to the orthogonal design optimization experiment, optimization method ultrasonic extraction technology, and ultimate pass to get the best synthetic condition for: material ratio 1.0,1.0,1.5(mol), ultrasonic power 100 w, ultrasonic time 2 hours, ultrasonic temperature 65°C, the yield is 61.08%.

APA, Harvard, Vancouver, ISO, and other styles

36

Rousseau, Anaïs, Guillaume Vincent, and Cyrille Kouklovsky. "Preparation of an advanced intermediate for the synthesis of leustroducsins and phoslactomycins by heterocycloaddition." Beilstein Journal of Organic Chemistry 18 (October 4, 2022): 1385–95. http://dx.doi.org/10.3762/bjoc.18.143.

Full text

Abstract:

A convergent strategy for the synthesis of leustroducsins and phoslactomycins has been designed, relying on the synthesis and the coupling of three main fragments. The central fragment was synthesized via a regio-and stereoselective nitroso Diels–Alder reaction with an enol phosphate, followed by reductive cleavage of the phosphate to the ketone 11b. Coupling studies of this fragment with the lactone fragment was accomplished in a stereoselective fashion through a vinyllithium intermediate. An advanced synthetic intermediate was then obtained after functional group transformation.

APA, Harvard, Vancouver, ISO, and other styles

37

Yamazaki, Yoshimitsu, Akihiko Maruyama, Kuniaki Hosono, Takanori Higashihara, and Harumi Kobayash. "Asymmetrie Reduction of Synthetic Ketones by Marine Microorganisms." Zeitschrift für Naturforschung C 48, no. 5-6 (1993): 451–56. http://dx.doi.org/10.1515/znc-1993-5-609.

Full text

Abstract:

Abstract Three strains of bacteria reducing (trifluoroacetyl)ferrocene (3) to optically pure (R)-2,2,2-trifluoro-l-hydroxyethylferrocene (4) and one bacterial strain reducing 3 to (S)-4 of moderate optical purity were isolated from sea-water collected at the coastal areas in Ibaraki prefecture of Japan. The former three strains were identified as Micrococcus lylae, Micrococcus luteus, and Deleya marina and the latter as Bacillus licheniformis. These strains also asymmetrically reduced some other synthetic ketones, e.g., 2,2,2-trifluoroacetophenone (7) and phenyl trimethylsilyl ketone (9). Furt

APA, Harvard, Vancouver, ISO, and other styles

38

Gholap, Shivajirao L., Sayani Das, Anju Bala, and Kapil Sharma. "First Total Syntheses of (±)-Callyspongidic Acids and 2-epi-(±)-Callyspongidic Acids." Synthesis 54, no. 09 (2022): 2225–32. http://dx.doi.org/10.1055/s-0041-1737805.

Full text

Abstract:

AbstractThe first total syntheses of (±)-callyspongidic acids and 2-epi-(±)-callyspongidic acids were achieved in high overall yield from epoxy ester derived from commercially available l-(+)-tartaric acid. The key features of these syntheses are the stereoselective opening of epoxide with organocuprates and the chemoselective addition of Grignard reagent to ketone in the presence of ester. The synthetic route reported here is operationally simple, very short and amenable for the synthesis of several analogues of this class.

APA, Harvard, Vancouver, ISO, and other styles

39

Edwankar, Chitra R., Rahul V. Edwankar, Sundari Rallapalli, and James M. Cook. "General Approach to the Total Synthesis of Macroline-Related Sarpagine and Ajmaline Alkaloids1." Natural Product Communications 3, no. 11 (2008): 1934578X0800301. http://dx.doi.org/10.1177/1934578x0800301114.

Full text

Abstract:

Described in this review is a general and efficient strategy for the synthesis of macroline-related sarpagine and ajmaline alkaloids. The tetracyclic ketone in the parent system, as well as the alkoxy substituted series served as templates for the synthesis of these complex molecules. The palladium-mediated enolate cross coupling process, regiospecific hydroboration, and Tollens reaction are some of the key transformations that have been employed for further functionalization of these templates. Synthetic routes that have been improved, in order to obtain gram quantities of these alkaloids for

APA, Harvard, Vancouver, ISO, and other styles

40

Senthil, Kumar Raju, Settu Archana, Thiyagarajan Archana, Rama Divya, Sekar Praveen, and Kumar Shridharshini. "Synthetic approaches of medicinally important Schiff bases: An updated Review." World Journal of Advanced Research and Reviews 16, no. 3 (2022): 838–52. https://doi.org/10.5281/zenodo.7903785.

Full text

Abstract:

The Schiff base defined by an imine or azomethine (-CH= N-) group, is mostly synthesized by the condensation reaction of carbonyl compounds (Aldehyde or Ketone) with compounds consisting of amine moiety. Schiff bases are among the most chiefly used organic compounds, revealing a wide range of applications, such as electroluminescent effects, fluorescence properties, nonlinear optical and chemosensory properties. The typical Schiff bases are crystalline solids that are basic, although at least some of them combine with strong acids to generate insoluble salt. Schiff bases are widely used in the

APA, Harvard, Vancouver, ISO, and other styles

41

Würthner, Frank, Alhama Arjona-Esteban, Anja Rausch, and Myroslav O. Vysotsky. "Merocyanine Dyes with Extended Polymethine Chains by Simple Two-Step Condensation Sequence." Synthesis 53, no. 02 (2020): 318–25. http://dx.doi.org/10.1055/s-0040-1707896.

Full text

Abstract:

We describe a synthetic method for the synthesis of merocyanine dyes containing a bridge with three conjugated double bonds. This method consists of two successive condensation reactions. The first one is made between CH-acidic indane-1,3-dione acceptor units and an appropriate ketone (here acetone or hexan-2-one). The extended acceptor thus obtained is condensed with an aldehyde in the next step. The dyes show high tinctorial strength due to intense absorption bands at wavelengths between 500 and 750 nm.

APA, Harvard, Vancouver, ISO, and other styles

42

Ramnauth, Jailall, and Edward Lee-Ruff. "Photodecarbonylation of chiral cyclobutanones." Canadian Journal of Chemistry 75, no. 5 (1997): 518–22. http://dx.doi.org/10.1139/v97-060.

Full text

Abstract:

Triplet photosensitized irradiation of 2(S),3(R)-bis[(benzoyloxy)methyl]cyclobutanone gave optically pure (−)E-1(S),2(S)-bis(benzoyloxymethyl)cyclopropane as a major product in the nonpolar fraction along with its stereoisomer and cycloelimination products. The absolute stereochemistry of the chiral cyclopropane was established by independent synthesis and X-ray crystal structure determination of a synthetic precursor. The distribution of decarbonylation and cycloelimination products was inversely dependent on the concentration of the substrate. Irradiation of the same ketone in tetrahydrofura

APA, Harvard, Vancouver, ISO, and other styles

43

Wang, Xiaoji, Shuangping Huang, Lixia Liu, Yongli Sun, Jiwu Wang, and Wentao Ou. "A New Formal Synthetic Route to Entecavir." Synlett 30, no. 06 (2019): 748–52. http://dx.doi.org/10.1055/s-0037-1612215.

Full text

Abstract:

We describe a new and straightforward approach to the formal synthesis of the hepatitis B virus inhibitor entecavir, an important hepatitis B drug, in ten steps overall. Key features of the route are a Morita–Baylis–Hillman reaction, a Sharpless asymmetric epoxidation, a reductive epoxide opening of an α,β-epoxy ketone, and a Riley selenium dioxide oxidation.

APA, Harvard, Vancouver, ISO, and other styles

44

Abdelhameed, Reda M., Luis D. Carlos, Artur M. S. Silva, and João Rocha. "Engineering lanthanide-optical centres in IRMOF-3 by post-synthetic modification." New Journal of Chemistry 39, no. 6 (2015): 4249–58. http://dx.doi.org/10.1039/c4nj02382j.

Full text

APA, Harvard, Vancouver, ISO, and other styles

45

Amick, Aaron W., Keith S. Griswold, and Lawrence T. Scott. "Synthesis and aldol cyclotrimerization of 4,7-di-tert-butylacenaphthenone." Canadian Journal of Chemistry 84, no. 10 (2006): 1268–72. http://dx.doi.org/10.1139/v06-062.

Full text

Abstract:

An efficient gram scale synthesis of the previously unknown 4,7-di-tert-butylacenaphthenone (3b) is reported. The facile isomerization of epoxide 9b to ketone 3b occurs simply on stirring a solution of 9b with silica gel at room temperature. Aldol cyclotrimerization of 3b with titanium tetrachloride gives 2,5,8,11,14,17-hexa-tert-butylde cacyclene (1b) in 58% isolated yield. X-ray crystal structures have been obtained for the synthetic intermediates 4,7-di-tert-butylacenaphthene (2b) and 4,7-di-tert-butylacenaphthylene (8b).Key words: aromatic, decacyclene, hydrocarbon, nonalternant, polycycli

APA, Harvard, Vancouver, ISO, and other styles

46

Amer Hamzah, Harina, Tom S. Crickmore, Daniel Rixson, and Andrew D. Burrows. "Post-synthetic modification of zirconium metal–organic frameworks by catalyst-free aza-Michael additions." Dalton Transactions 47, no. 41 (2018): 14491–96. http://dx.doi.org/10.1039/c8dt03312a.

Full text

Abstract:

UiO-66-NH<sub>2</sub> reacts with acrylonitrile, acrylic acid, methyl acrylate and methyl vinyl ketone leading to post-synthetic modification of the MOF through C–N bond formation. The acrylonitrile-modified MOF undergoes further reaction to form a tetrazolate-modified MOF.

APA, Harvard, Vancouver, ISO, and other styles

47

Bilgaiyan, P., A. Modi, and N. Shivhare. "The Versatility of Mannich Reaction: An Overview." Journal of Physics: Conference Series 2603, no. 1 (2023): 012031. http://dx.doi.org/10.1088/1742-6596/2603/1/012031.

Full text

Abstract:

Abstract - One of the most significant processes for creating carbon-carbon bonds in organic synthesis is the Mannich reaction. It offers amino carbonyl compounds, crucial synthetic building blocks for many medicines. This Mannich bases are made by combining primary and/or secondary amines, formaldehyde, and active hydrogen molecules. Among those that are active hydrogen compounds include an acid, phenol, ketone, amide, etc. contribution involved the synthesis of 3,5 dimethyl carboxamide using a number of biologically active sulphonamides, which was followed by analysis of elements and spectru

APA, Harvard, Vancouver, ISO, and other styles

48

Roopan, Selvaraj Mohana, Annadurai Bharathi, and Duraipandi Devi Priya. "Microwave Assisted Synthesis and Its Cytotoxicity Study of 4H-Pyrano[2,3-a]acridine-3-carbonitrile Intermediate: Experiment Design for Optimization Using Response Surface Methodology." Proceedings 41, no. 1 (2019): 12. http://dx.doi.org/10.3390/ecsoc-23-06594.

Full text

Abstract:

Several synthetic routes have been achieved to synthesize pyrane fused systems. As a follow up of earlier work, we hereby report the microwave assisted synthesis of key intermediate, pyrane fused acridine compounds 3a–f. It was obtained by treating α,β-unsaturated ketone 1a–f and malononitrile 2 in presence of piperidine with ethanolic solution at 50 C under 200 W power. This method also optimized via microwave method using RSM methodology. All the synthesized derivatives and target compounds were evaluated for cytotoxicity effect on human hepatoblastoma (HepG2) cell line and HDAC enzyme activ

APA, Harvard, Vancouver, ISO, and other styles

49

Hagiwara, Hisahiro, Shohei Fujiwara, Chikako Iibachi, Toshio Suzuki, and Takashi Hoshi. "A Synthetic Approach Toward a Brominated Oxocane Labdane Diterpenoid Isolated From Laurencia obtusa." Natural Product Communications 15, no. 3 (2020): 1934578X2091286. http://dx.doi.org/10.1177/1934578x20912866.

Full text

Abstract:

The synthesis of a labdane oxocane epoxy-alcohol is described starting from the Wieland–Miescher ketone derivative via ring closing olefin metathesis of a diene derivative, targeting the total synthesis of a brominated oxocane labdane diterpenoid isolated from Laurencia obtusa.

APA, Harvard, Vancouver, ISO, and other styles

50

Ojha, Pawan Kumar, Darbin Kumar Poudel, Sabita Dangol, et al. "Volatile Constituent Analysis of Wintergreen Essential Oil and Comparison with Synthetic Methyl Salicylate for Authentication." Plants 11, no. 8 (2022): 1090. http://dx.doi.org/10.3390/plants11081090.

Full text

Abstract:

A comparative analysis of Gaultheria fragrantissima (Ericaceae) essential oils based on geographical location, distillation time, and varying distillation conditions was carried out, and their compositions were evaluated by gas chromatography–mass spectrometry (GC–MS), chiral GC–MS, and gas chromatography–flame ionization detection (GC–FID). In addition, each of seven commercial wintergreen essential oil samples from Nepal and China were analyzed. The highest extraction yield was 1.48% and the maximum number of compounds identified in natural wintergreen oil was twenty-two. Based on distillati

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!