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1

De, Mora Kim Stephen. "Foundational technologies in synthetic biology : promoter measurement and peroxisome engineering." Thesis, University of Edinburgh, 2011. http://hdl.handle.net/1842/7870.

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The confluence of next generation DNA sequencing and synthesis when combined with the application of concepts such as standardization and modular design has led to the genesis of a new discipline. The nascent field of Synthetic Biology concerns the rational design and construction of genetic circuits, pathways, machines and eventually whole organisms. The immaturity of this field dictates that early research efforts, including this Thesis, describe foundational work towards the creation of tools which make biology more amenable to being engineered. The first part of this Thesis describes an at
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2

Qi, Zhan [Verfasser], and Veit [Akademischer Betreuer] Hornung. "Large-scale analysis of Drosophila core promoter function using synthetic promoters / Zhan Qi ; Betreuer: Veit Hornung." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2019. http://d-nb.info/1188200240/34.

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3

Huang, Hsin-Ho. "Promoter Engineering for Cyanobacteria : An Essential Step." Doctoral thesis, Uppsala universitet, Institutionen för kemi - Ångström, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-206901.

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Synthetic biology views a complex biological system as an ensemble in the hierarchy of parts, devices, systems, and networks. The practice of using engineering rules such as decoupling and standardization to understand, predict, and re-build novel biological functions from model-driven designed genetic circuits is emphasized. It is one of the top ten technologies that could help solving the current and potential risks in human society. Cyanobacteria have been considered as a promising biological system in conducting oxygenic photosynthesis to convert solar energy into reducing power, which dri
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4

Binge, Alexandra. "Development of endogenous and synthetic CHO promoter expression systems for recombinant protein production." Thesis, University of Kent, 2018. https://kar.kent.ac.uk/66640/.

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Chinese hamster ovary (CHO) cells are the most commonly used mammalian cell expression system for the industrial production of biotherapeutic recombinant proteins. Mammalian expression systems are a popular choice for the production of complex biopharmaceuticals due to their ability to correctly fold and assemble recombinant proteins and to carry out necessary human-like post-translational modifications. Traditionally, viral promoters are used to drive transgene expression in mammalian cells. This study reports on the investigation of endogenous CHO promoters as potential alternatives to the c
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5

McArthur, George Howard IV. "Orthogonal Expression of Metabolic Pathways." VCU Scholars Compass, 2013. http://scholarscompass.vcu.edu/etd/3087.

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Microbial metabolism can be tailored to meet human specifications, but the degree to which these living systems can be repurposed is still unknown. Artificial biological control strategies are being developed with the goal of enabling the predictable implementation of novel biological functions (e.g., engineered metabolism). This dissertation project contributes genetic tools useful for modulating gene expression levels (extending promoters with UP elements) and isolating transcription and translation of engineered DNA from the endogenous cellular network (expression by orthogonal cellular mac
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6

Seby, Sreya Mariya. "Effect of Promoter (Mn) on the Performance of SBA-15 Supported Iron Catalysts for High Temperature Fischer-Tropsch Synthesis." Scholar Commons, 2019. https://scholarcommons.usf.edu/etd/7932.

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Development of an effective High Temperature Fischer-Tropsch Synthesis (HTFTS) catalyst is of interest in process intensification that combines methane reforming with long chain hydrocarbon production. Literature indicates iron catalysts supported on mesoporous silica performed relatively well in high temperature applications. In this work, we investigated the effect of manganese promoter on iron catalysts for FTS at 430 °C as it was known from previous studies that manganese promotion could enhance the CO conversion with higher hydrocarbon
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7

Tueros, Farfán Felipe Gonzalo. "Desarrollo de un Circuito Genético Sintético Conformado por el Gen de la Proteína Verde Fluorescente (GFP) y el Promotor psp de Escherichia coli." Bachelor's thesis, Universidad Ricardo Palma, 2015. http://cybertesis.urp.edu.pe/handle/urp/838.

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El aumento de la actividad minera en el Perú hace necesario el desarrollo de tecnologías rápidas y económicas de detección de contaminantes para su monitoreo y control. Implementando conocimientos de biología molecular y de la regulación génica podemos construir un circuito genético sintético que posibilite el monitoreo de sustancia toxicas que generen estrés oxidativo como son los compuestos cianurados. El objetivo de esta investigación es desarrollar un circuito genético sintético conformado por el promotor de la proteína del shock por fagos (psp) de Escherichia coli y las secuencia codifica
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8

Elnour, Nada. "Reporter-based Synthetic Genetic Analysis of Budding Yeast Reveals Novel MMS-induced Effectors of the RNR3 Promoter." Thesis, Université d'Ottawa / University of Ottawa, 2016. http://hdl.handle.net/10393/35143.

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The DNA damage response is a cell-wide response that coordinates repair and cell-cycle progression. Crucial to fidelity of genetic propagation, survival, and apoptosis, dysfunctions in the response are at the root of genome instability syndromes and cancer predisposition in mammalian cells. Within the response lie hubs of coordination, called checkpoints, whose members and organization are ubiquitous amongst eukaryotes. The high conservation of these checkpoints enable the study of their dynamics by proxy via simpler model organisms. We use the budding yeast, Saccharomyces cerevisiae, to study
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9

Samuelsson, Magnus. "p57Kip2, a glucocorticoid-induced CDK inhibitor, involved in cell proliferation, apoptosis and differentiation /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-382-1/.

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10

Pinel, Karine. "Imagerie in vivo du contrôle de l’inhibition génique et de l’électroporation d’ARN." Thesis, Bordeaux 2, 2012. http://www.theses.fr/2012BOR22004/document.

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Ces travaux de thèse d’imagerie moléculaire et translationnelle proposent, sur des modèles murins, deux approches innovantes pour les thérapies géniques. La plupart des cancers sont associés à des dérégulations de l’expression génique et certains gènes sont surexprimés. L’utilisation de microARN (miARN) permet d’envisager une réduction de l’expression d’un gène spécifique mais il est nécessaire de limiter cette inhibition au tissu pathologique. L’utilisation des promoteurs thermo-inductibles couplés à un dépôt local de chaleur autorise un contrôle spatial et temporel de l’expression génique in
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11

Shi, Qiwen. "GADD45a-Targeted Suicide Gene Therapy for the Prevention or Treatment of Non-Small Cell Lung Carcinoma." Kent State University / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=kent1436485198.

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12

Boehm, Christian Reiner. "Gene expression control for synthetic patterning of bacterial populations and plants." Thesis, University of Cambridge, 2017. https://www.repository.cam.ac.uk/handle/1810/267842.

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The development of shape in multicellular organisms has intrigued human minds for millenia. Empowered by modern genetic techniques, molecular biologists are now striving to not only dissect developmental processes, but to exploit their modularity for the design of custom living systems used in bioproduction, remediation, and regenerative medicine. Currently, our capacity to harness this potential is fundamentally limited by a lack of spatiotemporal control over gene expression in multicellular systems. While several synthetic genetic circuits for control of multicellular patterning have been r
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13

Suleman, Essa. "Mutational analysis of the PacC binding sites within the aflR promoter in Aspergillus flavus." Thesis, Nelson Mandela Metropolitan University, 2011. http://hdl.handle.net/10948/d1012683.

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It is generally known that media containing simple sugars (sucrose, glucose) and organic nitrogen sources (ammonium) when buffered to acidic pH stimulates aflatoxin production in Aspergillus flavus & A. parasiticus while lactose, nitrate and an alkaline pH inhibit aflatoxin biosynthesis. It has been shown that pH of the growth medium is the most important regulatory factor for aflatoxin biosynthesis since media containing stimulatory carbon and/or nitrogen sources (sucrose and ammonia) do not enhance aflatoxin (or sterigmatocystin) production at alkaline pH. RNA interference (in A. flavus) of
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14

Glynn, Daniel Joseph. "New aspects in aluminium promoted organic synthesis." Thesis, University of Nottingham, 2011. http://eprints.nottingham.ac.uk/12048/.

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In the first chapter of this thesis the aluminium promoted zinc Schlenk equilibrium of FG-ArZnX/AlMe3 is shown to provide good access for the synthesis of chiral secondary alcohols. This practical asymmetric 1,2-addition to aliphatic and aromatic aldehydes uses only commercially available reagents and ligands. Enantioselectivity is provided by the use of (1R,2S)-dibutylnorephedrine (1,2-amino alcohol ligand) giving selectivity, in most cases, between 80-96% ee. Yields are moderate to good, typically alcohols are prepared in 50-97% yield. Uniquely the FG-ArZnBr species can be prepared in situ d
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15

Taylor, T. M. C. "Modified phospholipids : Oxidation promoted by vesicle-bound metal ions." Thesis, University of Oxford, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.382664.

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16

Devlin, John Francis. "Synthetic and mechanistic aspects of some transition metal promoted reactions." Thesis, Queen's University Belfast, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.317054.

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17

Madsen, Mary Ann. "Growth phase-specific promoters of cyanobacteria for synthetic biology applicatations." Thesis, University of Glasgow, 2016. http://theses.gla.ac.uk/7359/.

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18

Zhong, Cheng. "Amine promoted asymmetric cascade synthesis of highly functionalized heterocycles." Morgantown, W. Va. : [West Virginia University Libraries], 2010. http://hdl.handle.net/10450/10986.

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Thesis (Ph. D.)--West Virginia University, 2010.<br>Title from document title page. Document formatted into pages; contains xvi, 498 p. : ill. (some col.). Includes abstract. Includes bibliographical references (p. 75-82).
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19

Lefever, Mark. "DESIGN, SYNTHESIS AND CHARACTERIZATION OF HELICAL OPIOID GLYCOPEPTIDES AND FLUORESCENT DERIVATIVES INCLUDING OPTIMIZATION OF SERINE GLYCOSYLATION UTILIZING SUGAR ACETATES." Diss., The University of Arizona, 2010. http://hdl.handle.net/10150/193791.

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Our effort to provide an efficient route to serine glycosides with utility in glycopeptide synthesis has led to the identification of two particularly effective promoters of O-glycosylation. Indium(III) bromide and scandium(III) triflate were shown to be superior promoters of microwave accelerated O-glycosylation utilizing peracetyl carbohydrate donors. 247, 249 These Lewis acids afforded several advantages over previously described promoters including, increased yields, tolerance to moisture, decreased environmental toxicity, ease of work up, and increased reproducibility. Both affected the m
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20

Braidotti, Giovanna. "Studies of the promoter region of the rat housekeeping 5-aminolevulinate synthase gene /." Title page, contents and summary only, 1992. http://web4.library.adelaide.edu.au/theses/09PH/09phb814.pdf.

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21

Comas-Barceló, Júlia. "Lewis acid-promoted synthesis of pyrazole building blocks." Thesis, University of Sheffield, 2016. http://etheses.whiterose.ac.uk/15943/.

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The present work investigated copper(II)-promoted regioselective synthesis of disubstituted pyrazole scaffolds via cycloaddition reactions between sydnones and alkynes. Cu(OTf)2 has been found to mediate the formation of 1,3-pyrazoles, while Cu(OAc)2·H2O promotes the exclusive formation of the 1,4-regioisomer. Both transformations have been optimised and the scope has been explored for both reactions. A mechanistic proposal is also reported herein that has been derived from both experimental and theoretical investigations, the latter performed in collaboration with colleagues at Universidad de
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22

Camsund, Daniel. "Engineering Transcriptional Systems for Cyanobacterial Biotechnology." Doctoral thesis, Uppsala universitet, Molekylär biomimetik, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-223599.

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Cyanobacteria are solar-powered cell factories that can be engineered to supply us with renewable fuels and chemicals. To do so robust and well-working biological parts and tools are necessary. Parts for controlling gene expression are of special importance in living systems, and specifically promoters are needed for enabling and simplifying rational design. Synthetic biology is an engineering science that incorporates principles such as decoupling, standardization and modularity to enable the design and construction of more advanced systems from simpler parts and the re-use of parts in new co
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23

Fraser, Ian. "The feasibility of high synthesis gas conversion over ruthenium promoted iron-based Fischer Tropsch catalyst." Thesis, Cape Peninsula University of Technology, 2017. http://hdl.handle.net/20.500.11838/2588.

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Thesis (MTech (Chemical Engineering))--Cape Peninsula University of Technology, 2017.<br>One of the very promising synthetic fuel production strategies is the Fischer-Tropsch process, founded on the Fischer-Tropsch Synthesis, which owes its discovery to the namesake researchers Franz Fischer and Hans Tropsch. The Fischer-Tropsch Synthesis (FTS) converts via complex polymerisation reaction a mixture of CO and H2 over transition metal catalysts to a complex mixture of hydrocarbons and oxygen containing compounds with water as major by-product. The mixture of CO and H2 (termed syngas) may b
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24

Cairns, Pete. "Oxygenates in iron Fischer-Tropsch synthesis : is copper a selectivity promoter?" Doctoral thesis, University of Cape Town, 2008. http://hdl.handle.net/11427/5361.

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Includes synopsis.<br>Includes bibliographical references (p. 188-197).<br>The Fischer-Tropsch synthesis is regarded as a stepwise polymerisation reaction between adsorbed hydrogen, carbon monoxide and monomers formed from them. Commercially, a supported precipitated iron catalyst promoted with small amounts of potassium and copper is one of the catalysts used in this reaction. Precipitated iron catalysts are chemically promoted with potassium in order to enhance the product selectivity, while copper is added as a reduction promoter which increases the reduction rate and decreases the reductio
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25

李安怡 and On-yi Lee. "Synthesis of heterocycles via phenylseleno group transfer radical cyclization and chemoselective reductive amination promoted by InCl3." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B3955756X.

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26

Cai, Xuediao. "Synthesis and Characterization of Pyrrole Based Adhesion Promoter Systems on Oxide Substrates." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2005. http://nbn-resolving.de/urn:nbn:de:swb:14-1109334028224-37122.

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For grafting polypyrrole on oxidized surfaces, 3-substituted pyrrole alkyl phosphonic acids, 11-(pyrrol-3-yl undecyl) trimethoxysilanes and 1-substituted pyrrole alkyl organosilanes with different chain length were designed and successfully synthesized as adhesion promoters. These new derivatives were studied for their adsorption behavior on oxide substrates and chemical or electrochemical deposition of polypyrrole over modified oxide surface or electrodes. Several analytical techniques such as contact angle measurement, surface plasmon resonance spectroscopy (SPR), UV-VIS Spectroscopy, grazin
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27

Cai, Xuediao. "Synthesis and Characterization of Pyrrole Based Adhesion Promoter Systems on Oxide Substrates." Doctoral thesis, Technische Universität Dresden, 2004. https://tud.qucosa.de/id/qucosa%3A24463.

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For grafting polypyrrole on oxidized surfaces, 3-substituted pyrrole alkyl phosphonic acids, 11-(pyrrol-3-yl undecyl) trimethoxysilanes and 1-substituted pyrrole alkyl organosilanes with different chain length were designed and successfully synthesized as adhesion promoters. These new derivatives were studied for their adsorption behavior on oxide substrates and chemical or electrochemical deposition of polypyrrole over modified oxide surface or electrodes. Several analytical techniques such as contact angle measurement, surface plasmon resonance spectroscopy (SPR), UV-VIS Spectroscopy, grazin
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28

Gao, Qiang, and 高強. "Novel Lewis Acid-promoted cyclization reactions and synthesis of triptolide analogs." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2003. http://hub.hku.hk/bib/B31245316.

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29

Bhattacharyya, Souryadeep. "Synthetic sensing systems in Saccharomyces cerevisiae." Thesis, Georgia Institute of Technology, 2014. http://hdl.handle.net/1853/54016.

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The yeast Saccharomyces cerevisiae is a major chemical production platform in the biotechnological industry. It is also increasingly being used as a whole cell biosensor. One method of developing such whole cell biosensors in yeast is by exploiting its mating pathway, which is normally induced by secreted pheromones leading to downstream expression of various genes. Functional expression of different recognition elements or receptors and their coupling to the yeast mating pathway can enable sensing of a variety of ligands. In this work, we have engineered a yeast strain to functionally express
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30

Parker, Gregory Dominic. "The stereoselective synthesis of substituted tetrahydropyrans using acid-promoted prins cyclisations." Thesis, University of Bristol, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.399393.

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31

Chan, Jessica Zee. "Stereoselective Functionalization of Carbonyl Compounds and N-Alkylamines Promoted by Cooperative Catalysts:." Thesis, Boston College, 2020. http://hdl.handle.net/2345/bc-ir:108940.

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Thesis advisor: Masayuki Wasa<br>This dissertation describes the development of cooperative catalyst systems for the functionalization of monocarbonyl compounds and stereoselective transformations of alpha-C–H bonds of N-alkylamines, inspired by the concepts of frustrated Lewis pairs (FLPs). Prior to this dissertation research, practical and broadly applicable C–C and C–heteroatom bond forming reactions involving the FLP complexes that provide synthetically desirable products with high enantioselectivity remained to be developed. Chapter 1 of this dissertation describes the recent advances in
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32

Cheung, Charles Y. "Synthetic, pH-sensitive polymers that promote the intracellular delivery of nonviral gene therapy vectors /." Thesis, Connect to this title online; UW restricted, 2003. http://hdl.handle.net/1773/8103.

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33

Wright, James H. "Potassium-promoted molybdenum catalysis higher alcohols from synthesis gas over MoC, Mo₂C and MoO₂ /." Morgantown, W. Va. : [West Virginia University Libraries], 2006. https://eidr.wvu.edu/etd/documentdata.eTD?documentid=4799.

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Thesis (M.S.)--West Virginia University, 2006.<br>Title from document title page. Document formatted into pages; contains xiii, 172 p. : ill. (some col.). Includes abstract. Includes bibliographical references (p. 123-125).
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34

Björkman, Margareta. "Palladium-promoted synthesis of compounds labelled with ¹¹C : Synthesis of ¹¹C-labelled prostacyclin and prostaglandin analogues." Doctoral thesis, Uppsala University, Department of Chemistry, 2000. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1071.

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<p>Palladium-promoted reactions have been employed for the synthesis of compounds labelled with <sup>11</sup>C (t<sub>½</sub> = 20.3 min). The precursor [<sup>11</sup>C]methyl iodide was used in palladium-promoted cross-coupling reactions with organostannanes. With this method, large molecules with several functional groups, that is prostacyclin analogues, have been synthesised in up to 54 % decay-corrected radiochemical yield, calculated from [<sup>11</sup>C]methyl iodide. However, since this method did not afford reproducible yields, a second method where copper(I) was used as a co-catalyst
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35

Powell, David Andrew. "Mercury-promoted synthesis of substituted 5-aminotetrazoles and studies towards the synthesis of the martinelline alkaloids." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/MQ58759.pdf.

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36

Gilman, James. "Heuristic discovery and design of promoters for the fine-control of metabolism in industrially relevant microbes." Thesis, University of Exeter, 2018. http://hdl.handle.net/10871/34620.

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Predictable, robust genetic parts including constitutive promoters are one of the defining attributes of synthetic biology. Ideally, candidate promoters should cover a broad range of expression strengths and yield homogeneous output, whilst also being orthogonal to endogenous regulatory pathways. However, such libraries are not always readily available in non-model organisms, such as the industrially relevant genus Geobacillus. A multitude of different approaches are available for the identification and de novo design of prokaryotic promoters, although it may be unclear which methodology is mo
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37

Liu, Chang. "Effect of sulphur on Fischer-Tropsch synthesis : promoted molybdenum and cobalt catalysts." Thesis, Lille 1, 2015. http://www.theses.fr/2015LIL10134/document.

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Cette thèse porte sur l’étude de catalyseurs promus à base de sulfure de molybdène supporté sur alumine ou nanotubes de carbone pour la synthèse d’oléfines à partir du gaz de synthèse issu de la biomasse. Les catalyseurs ont été étudiés à chaque étape de leur préparation par différentes techniques physico-chimiques et spectroscopiques et testés dans un réacteur à lit fixe. Les résultats ont montré que deux types de sites sont présents sur les catalyseurs K-MoS2 : MoS2, qui conduit à la production de méthane et une phase mixte K-Mo-S qui conduit à la synthèse d’oléfines. La baisse d’activité ob
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38

Cai, Yu. "Microwave-Promoted Iminyl Radical Cyclizations for the Synthesis of Azaheterocycles and the Total Synthesis of Yaku'amide A." BYU ScholarsArchive, 2017. https://scholarsarchive.byu.edu/etd/6992.

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Two different research projects are described in this dissertation. The first one focuses on microwave-promoted iminyl radical cyclization for the formation of azaheterocycles which are embedded within numerous pharmaceuticals and biologically active natural products (such as clindamycin, eletriptan, moxiflaxin, etc.). We are quite interested in this project because of the significance of nitrogen-containing heterocycles as pharmaceuticals and organocatalysts combined with the need for safe, simple, and economical means of constructing them. We have successfully developed an efficient one-step
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39

Liu, Zenghui. "I. On the Mechanism of Acid Promoted Rearrangement of PCU-Derived Pinacols II. Synthesis of a Trimethyltrishomocubyl Helical Tubuland Diol." Thesis, University of North Texas, 1995. https://digital.library.unt.edu/ark:/67531/metadc277859/.

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I. Reductive dimerization of pentacyclo[5.4.0.0.^2,6.0^3,10.0^5'9]undecane-8-one-(PCU-8-one, 53) affords a mixture of meso and d,l pinacols (55a and 55b respectively). Acid promoted rearrangement of 55a and 55b conceivably can proceed with migration of C(7)-C(8) and/or C(8)-C(9) to form the corresponding pinacolone(s). In our hands, acid promoted rearrangement of 55a and 55b each proceeds with exclusive migration of C(7)- C(8) bond, thereby affording 58a and 59a respectively. Mechanistic features of this rearrangement are discussed. II. 4,7,1 l-trimethylpentacyclo[6.3.0.0.^2,6.0^3,l0.0^5,9]
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Bircher, Sam. "Phytoremediation of natural and synthetic steroid growth promoters used in livestock production by riparian buffer zone plants." Thesis, University of Iowa, 2011. https://ir.uiowa.edu/etd/2675.

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41

Sun, Huikai. "Iron tricarbonyl promoted cyclizations potential application toward total synthesis of 18-deoxycytochalasin H /." online version, 2008. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=case1190143838.

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42

Li, Liwei. "Density functional theory study of alcohol synthesis reactions on alkali-promoted Mo2C catalysts." Diss., Georgia Institute of Technology, 2014. http://hdl.handle.net/1853/53456.

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As an important chemical raw material, alcohols can be used as fuels, solvents and chemical feedstocks to produce a variety of downstream products. With limited fossil fuel resources, alcohol synthesis from syngas reactions can be a potential alternative to the traditional petroleum based alcohol synthesis. Among many catalysts active for syngas to alcohol processes, alkali promoted Mo2C has shown promising performance. More interestingly, the alkali promoter was found to play an important role in shifting the reaction selectivity from hydrocarbons to alcohols. However, limited understanding o
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SUN, HUIKAI. "IRON TRICARBONYL PROMOTED CYCLIZATIONS: POTENTIAL APPLICATION TOWARD TOTAL SYNTHESIS OF 18-DEOXYCYTOCHALASIN H." Case Western Reserve University School of Graduate Studies / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=case1190143838.

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44

Sahibzada, Mortaza. "Methanol synthesis from CO2/H2 over Pd-promoted Cu/ZnO/A12)3 catalysts." Thesis, Imperial College London, 1995. http://hdl.handle.net/10044/1/11472.

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45

Barba, Moreno Laura 1989. "Chromatin-bound DYRK1A : promoter occupancy and implications in the regulation of ribosomal protein gene expression." Doctoral thesis, Universitat Pompeu Fabra, 2018. http://hdl.handle.net/10803/664664.

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DYRK1A (dual-specificity tyrosine-regulated kinase 1A) belongs to a conserved family of protein kinases present in all eukaryotes. DYRK1A is known to participate in cell proliferation and differentiation decisions and to fulfill key roles in brain development. Data from our laboratory indicate that DYRK1A acts as a transcriptional activator directly at proximal promoter regions of genes containing a conserved palindromic motif. In this Thesis work, the mechanism of DYRK1A recruitment to chromatin has been explored, as well as the DYRK1A transcriptional effect on a subset of gene targets, namel
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46

Swigelaar, Wendell Peter. "The synthesis of 3-allyl-4-ethyl-2- (1'-hydroxyethyl)-1-methoxynaphthalene and its behaviour towards base- and palladium-promoted cyclisation under aerobic and anaerobic conditions." Thesis, University of the Western Cape, 2005. http://etd.uwc.ac.za/index.php?module=etd&amp.

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Over the years, Giles and co-workers have established that, upon treatment with potassium tert-butoxide, tetra-substituted naphthalenes undergo cyclisations to afford naphthopyrans. It was suggested that these base-induced cyclisations was as a result of the reacting centers being forced into close proximity as a consequence of steric crowding.<br /> <br /> This thesis describes the synthesis of 3-allyl-4-ethyl-2-(1&prime<br>-hydroxyethyl)-1-methoxy-naphthalene 177 and its behaviour towards Pd(0) and potassium tert-butoxide under aerobic and anaerobic conditions, to verify whether the base-pro
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47

Morrill, Michael R. "Higher alcohol synthesis on magnesium/aluminum mixed oxide supported potassium carbonate promoted molybdenum sulfide." Diss., Georgia Institute of Technology, 2013. http://hdl.handle.net/1853/52190.

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Higher alcohols synthesized via CO hydrogenation reactions have been a topic of intense study both in industry and academia for over thirty years. A variety of transition metals and promoters have been used in catalysts for this reaction. MoS₂, in particular, is popular due to its low cost, resistance to sulfur poisoning, and ability to selectively produce higher alcohols over hydrocarbons. The bulk material has a rich history in hydrodesulfurization reactions (HDS), and as such, a great deal is known about the material's structure and reactivity. However, even with this deep body of knowledge
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48

Tait, Joanne Margaret. "Water-promoted reactions for organic synthesis : the Claisen rearrangement and the Baylis-Hillman reaction." Thesis, University of Reading, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.250705.

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49

O'Malley, P. J. R. "Adsorption and reaction on promoted zinc oxide catalysts in relation to higher alcohol synthesis." Thesis, Imperial College London, 1987. http://hdl.handle.net/10044/1/47515.

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50

Zhou, Xiwen. "Study of shape effect of Pd promoted Ga2O3 nanocatalysts for methanol synthesis and utilization." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:ed45a832-d0d5-4f1d-8c14-aa54df10e8cb.

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The area of methanol synthesis and utilization has been attracting research interests due to its positive impact on the environment and also from energy perspectives. Methanol synthesis from CO<sub>2</sub> hydrogenation not only produces methanol which is a key platform chemical and a clean fuel, but can also recycle CO<sub>2</sub> which is one of the major greenhouse gases causing global warming. As a mobile energy carrier (particularly as a hydrogen carrier), methanol is a versatile molecule which is able to generate H<sub>2</sub> via its decomposition. Catalysis plays a decisive role in the
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