Relevant bibliographies by topics / Syringes

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
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Academic literature on the topic 'Syringes'

Author: Grafiati
Published: 4 June 2021
Last updated: 30 July 2024

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Journal articles on the topic "Syringes"

1

Emerson, Geoffrey G. "Silicone Oil Droplets are More Common in Fluid From BD Insulin Syringes as Compared to Other Syringes." Journal of VitreoRetinal Diseases 1, no. 6 (October 11, 2017): 401–6. http://dx.doi.org/10.1177/2474126417735963.

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Purpose: During 2016 and 2017, numerous retina specialists reported silicone oil droplets after intravitreal injection, primarily associated with insulin syringes with a fixed needle. By contrast, adverse events were relatively rare for tuberculin syringes. We hypothesized that fixed-needle syringe injections have more silicone droplets due to the lack of dead space at the syringe–needle junction. Methods: Fluid from Becton Dickenson (BD) insulin syringes, BD tuberculin syringes, Henke Sass Wolf (HSW) insulin syringes, and HSW silicone-free syringes was examined microscopically for silicone oil droplets. Fluid was sampled at the beginning, middle, and end of injection; and droplets were photographed and quantified. Results: Silicone oil droplets were identified in 30% of the BD insulin syringes, measuring 0.9 ± 0.2 mm3; no oil droplets were found in BD tuberculin syringes or HSW silicone-free syringes (analysis of variance, P < .05). All 6 samples with silicone oil droplets were from the end of injection (full depression of the plunger), while samples from the beginning and middle of injections did not have droplets. Challenging syringes with extra silicone oil resulted in increased droplets for fixed-needle syringes (but not for syringes with detachable needles). Conclusion: Significant silicone oil droplets were present in BD insulin syringes and were expressed at the end of injection (with plunger depressed maximally), supporting the hypothesis that insulin syringe injections have more droplets due to the lack of dead space where the plunger meets the hub of the needle. However, there are additional factors such as the amount or type of silicone lubricant in a syringe.
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Cepeda, Javier A., Jose Luis Burgos, James G. Kahn, Rosario Padilla, Pedro Emilio Meza Martinez, Luis Alberto Segovia, Tommi Gaines, et al. "Evaluating the impact of global fund withdrawal on needle and syringe provision, cost and use among people who inject drugs in Tijuana, Mexico: a costing analysis." BMJ Open 9, no. 1 (January 2019): e026298. http://dx.doi.org/10.1136/bmjopen-2018-026298.

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ObjectiveFrom 2011 to 2013, the Global Fund (GF) supported needle and syringe programmes in Mexico to prevent transmission of HIV among people who inject drugs. It remains unclear how GF withdrawal affected the costs, quality and coverage of needle and syringe programme provision.DesignCosting study and longitudinal cohort study.SettingTijuana, Mexico.ParticipantsPersonnel from a local needle and syringe programme (n=6) and people who inject drugs (n=734) participating in a longitudinal study.Primary outcome measuresProvision of needle and syringe programme services and cost (per contact and per syringe distributed, in 2017 $USD) during GF support (2012) and after withdrawal (2015/16). An additional outcome included needle and syringe programme utilisation from a concurrent cohort of people who inject drugs during and after GF withdrawal.ResultsDuring the GF period, the needle and syringe programme distributed 55 920 syringes to 932 contacts (60 syringes/contact) across 14 geographical locations. After GF withdrew, the needle and syringe programme distributed 10 700 syringes to 2140 contacts (five syringes/contact) across three geographical locations. During the GF period, the cost per harm reduction contact was approximately 10-fold higher compared with after GF ($44.72 vs $3.81); however, the cost per syringe distributed was nearly equal ($0.75 vs $0.76) due to differences in syringes per contact and reductions in ancillary kit components. The mean log odds of accessing a needle and syringe programme in the post-GF period was significantly lower than during the GF period (p=0.02).ConclusionsWithdrawal of GF support for needle and syringe programme provision in Mexico was associated with a substantial drop in provision of sterile syringes, geographical coverage and recent clean syringe utilisation among people who inject drugs. Better planning is required to ensure harm reduction programme sustainability is at scale after donor withdrawal.
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Suriawati, Junie, Reni Anggraini, Siti Rahayu Rachmawati, and Yulis Adriana. "Sterility Test of Syringes As A Pharmaceutical Preparation That Obtained From Pasar Pramuka." SANITAS: Jurnal Teknologi dan Seni Kesehatan 12, no. 2 (December 23, 2021): 186–98. http://dx.doi.org/10.36525/sanitas.2021.17.

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Syringes are one of the pharmaceutical preparations that are in high demand. In healthcare institutions, syringes are used to aid in patient care and examination. Pharmaceutical preparations, such as various syringes, are widely available in the Pasar Pramuka. Syringes must be free from microbes and used syringes should not be reused. Microbiological sterility tests can be performed on a syringe to determine whether it is sterile or not. The purpose of the study is to test the sterility of syringes obtained from the Pasar Pramuka. A random sample of a syringe is being used in the study as an experimental method. The syringes were isolated and incubated for 14 days in Fluid Thioglycollate Medium (FTM) and Trypticase Soy Broth (TSB) at 30-35 oC and 20-25 oC, respectively, with frequent observations. If FTM and TSB media were turbid, then isolated into selective media based on their microbe as controls, namely Clostridium sporogenes ATCC 19404, Pseudomonas aeruginosa ATCC 9027, Staphylococcus aureus ATCC 6538, Escherichia coli ATCC 25922, Escherichia coli ATCC 8739, Bacillus subtilis ATCC 6633, Salmonella typhi. The results showed that the B syringe was turbid on FTM media and did not contain pathogenic microbes after being identified on selective media, as in controls. The A and C syringes on TSB media were turbid, and after identification on selective media, Candida albicans and Aspergillus brasiliensis were found. In conclusion, the A, B, and C syringes are not steril.
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Cleland, Charles M., Sherry Deren, Crystal M. Fuller, Shannon Blaney, James M. McMahon, Stephanie Tortu, Don C. Des Jarlais, and David Vlahov. "Syringe Disposal Among Injection Drug Users in Harlem and the Bronx During the New York State Expanded Syringe Access Demonstration Program." Health Education & Behavior 34, no. 2 (August 4, 2006): 390–403. http://dx.doi.org/10.1177/1090198106288560.

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Effective January 1, 2001, New York State enacted the Expanded Syringe Access Demonstration Program (ESAP), allowing syringes to be sold in pharmacies without a prescription or dispensed through doctors, hospitals, and clinics to adults. A concern in the assessment of ESAP is its effects on syringe disposal practices. Syringe use data regarding the last injection episode were combined from three projects ( N = 1,030) recruiting injection drug users. Disposal of syringes by methods known to be safe decreased significantly over time after the implementation of ESAP. Syringes obtained either from syringe exchange programs or ESAP sources were more likely to be disposed of safely than syringes obtained from other sources. Efforts to enlist pharmacists and others involved in ESAP implementation to encourage safe disposal are needed. More detailed information on disposal practices is needed to capture the continuum from least to most safe practices and variation within individuals.
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Rudolph, James L., Daniel Tilahun, Patrick R. Treanor, Val E. Pochay, Meetali A. Mahendrakar, Praveen Sagar, and Viken L. Babikian. "Use of a large bore syringe creates significantly fewer high intensity transient signals (HITS) into a cardiopulmonary bypass system than a small bore syringe." Perfusion 21, no. 1 (January 2006): 67–71. http://dx.doi.org/10.1191/0267659106pf843oa.

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Introduction: High intensity transient signals (HITS) have been reported to occur following perfusionist intervention during cardiac surgery. This study investigates the relationship of the syringe bore, injection rate, and HITS created. Methods: Syringes (10 mL) with a male luer-lock connection (Large Bore) and Abboject ‘jet syringes’ with a 20 GA needle and male luer-lock connector (Small Bore) were filled with 10 mL of 0.9 N saline. A perfusionist was randomly assigned a set of four similar syringes followed by the other syringe bore. Each of the four syringes was injected into an in vitro saline-primed cardiopulmonary bypass (CPB) system over 5, 10, 15, or 20 sec. Sixteen randomizations of small and large bore syringes were completed at the four injection times (128 injections). HITS in the CPB arterial line were detected with transcranial Doppler (TCD) probes, were recorded for the 2 min following the injection, and were counted independently off-line by two reviewers. Results: The use of a large bore syringe compared to a small bore syringe created significantly fewer HITS (29±6 versus 145±17 [mean±SEM], p <0.001) introduced into the CPB arterial line. Injection over a longer time produced significantly fewer HITS than shorter injection times ( p <0.001). Conclusion: Significantly fewer HITS are introduced into the CPB system by using standard syringes and slower injection time.
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Whiteley, Mark S., and Salil B. Patel. "Modified Tessari Tourbillon technique for making foam sclerotherapy with silicone-free syringes." Phlebology: The Journal of Venous Disease 30, no. 9 (October 6, 2014): 614–17. http://dx.doi.org/10.1177/0268355514554476.

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The longevity of foam made using sodium tetradecyl sulphate and gas (air or a CO2:O2 mixture) is increased significantly if silicone-free syringes are used over the normal syringes containing silicone oil lubrication. However, the plungers in silicone-free syringes start sticking after several passages when making foam for sclerotherapy, preventing the smooth injection of the resulting foam. We describe a three syringe technique which allows foam to be made using the Tessari Tourbillon ‘three-way stopcock’ principle between two syringes, but with the foam ending up in a third syringe which has not undergone multiple passages of the plunger. This allows a smoother injection of the resultant foam, which is particularly useful when injecting small diameter veins under ultrasound control.
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Blasetti, Francesco, Donatella Usai, Salvatore Sotgia, Ciriaco Carru, Stefania Zanetti, and Antonio Pinna. "A protocol for microbiologically safe preparation, storage, and use of autologous serum eye-drops in low-income countries." Journal of Infection in Developing Countries 9, no. 01 (January 15, 2015): 055–59. http://dx.doi.org/10.3855/jidc.4733.

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Introduction: The study aimed to investigate whether the preparation, storage, and use of autologous serum in insulin syringes is microbiologically safe. Methodology: Blood samples (10 mL) were obtained from 10 volunteers. After centrifugation, the supernatant serum was removed and distributed in 5 sterile insulin syringes for each sample; syringes were numbered 0 to 4 and labelled with the subject’s details. Syringes were immediately transported to the microbiology laboratory and stored in a refrigerator at +4°C. The “0” labelled syringes were separated from the others and 100 µl of serum from each syringe was immediately seeded on chocolate and Sabouraud agar plates, which were incubated aerobically at 37°C for 96 hours to detect any bacterial and/or fungal contamination. In the next 4 days, the same procedure was repeated for the remaining syringes: on day 1, the “1” labelled syringes were analyzed; on day 2, the “2” labelled ones, and so on. In a second experiment, blood samples were obtained from 5 different volunteers. The same procedure as above was followed, but each syringe was used for repeated cultures at 2-hour intervals, for a total of 12 cultures/day. The needle was removed and replaced for each inoculation and the syringes were stored in the refrigerator after use. Results: Under these experimental conditions, none of the cultures showed microbial growth. Conclusions: Results suggest that, under the protocol described, preparation, storage and use of undiluted autologous serum in insulin syringes is inexpensive, fast, and microbiologically safe. This is of great importance for low-income countries.
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Gladwin, J., S. Maese, and B. Ballisat. "Investigating the Use of Nonloss of Resistance Syringes for Epidural Insertion: Experience on a Mannequin." Obstetric Anesthesia Digest 43, no. 3 (August 23, 2023): 129. http://dx.doi.org/10.1097/01.aoa.0000946316.44191.b0.

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(Int J Obstet Anesth. 2022;52:103595) The Obstetric Anaesthetists’ Association (OAA) announced a supply disruption of the Portex Loss of Resistance (LOR) Syringe, a commonly used tool for epidural catheter insertion. Several studies have shown no difference in epidural insertion success rates when using LOR to saline or air. Other methods for epidural space identification are being considered yet limited research compares specific low-resistance syringes with standard syringes. This study aimed to compare specific LOR syringes with syringes commonly used in epidural insertion.
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Nasri Ishak, Mohd, Abd Rahim Abu Talib, and Mohammad Yazdi Harmin. "Material selection and design analysis of multi-purpose disposable safety syringe." International Journal of Engineering & Technology 7, no. 4.13 (October 9, 2018): 214–20. http://dx.doi.org/10.14419/ijet.v7i4.13.21358.

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Current design of safety syringes requires two handed operation and additional processes which is not similar to the normal syringes. Due to this concern, a new design of safety syringe is introduced in order to produce a safety syringe which allows a single-handed operation and similar to the operation of a normal syringes. This paper presents the material selection process and design analysis of a newly devel-oped multi-purpose disposable safety syringe. Based on the design analysis, the force which needed to dismantle the nozzle is found to be 20 N and this value is practical for the end users. The finite element analysis had also shown that the design concept is safe and has safety feature for the user to use. In addition, copolymer is proven as the best material selection for safety syringe production.
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Smeenk, FW, JD Janssen, BJ Arends, GA Harff, JA van den Bosch, JP Schonberger, and PE Postmus. "Effects of four different methods of sampling arterial blood and storage time on gas tensions and shunt calculation in the 100% oxygen test." European Respiratory Journal 10, no. 4 (April 1, 1997): 910–13. http://dx.doi.org/10.1183/09031936.97.10040910.

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At the present time, plastic syringes are most commonly used for collecting arterial blood. The oxygen tension of the arterial blood (Pa,O2) in these syringes may fall. We studied the effect of the type of syringe, metabolism, and storage time on the arterial oxygen pressures measured and on the pulmonary shunt calculated. In 10 patients, 2-3 h after aortacoronary bypass surgery, a 100% oxygen test was performed. Four arterial blood gas samples were withdrawn from each patient in random order, two in glass syringes and two in plastic syringes. One glass and one plastic syringe were stored at room temperature (RT), and the others were stored in ice-water (IW). Each sample was analysed as soon as possible, and repeated 15, 30, 60 and 120 min after sampling. The Pa,O2 measurement in blood in the glass syringe in IW measured as soon as possible after sampling was considered the "gold standard". Pulmonary shunt calculations were performed using the results of the various blood gas analyses. Compared with the "gold standard", all of the other methods showed significant deterioration in the Pa,O2 measurement. The effect due to diffusion was 0.05 kPa x min(-1), and that due to metabolism 0.11 kPa x min(-1). The Pa,O2 in the glass syringes stored in IW remained stable with time. The pulmonary shunt was significantly overestimated when the "gold standard" blood gas results were not used (range 0.8-9.9%). Glass (not plastic) syringes should be used in the 100% oxygen test. The syringe should be cooled immediately, even when the sample is analysed as soon as possible.
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Dissertations / Theses on the topic "Syringes"

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O'Connell, Sean Patrick. "Hot-melt Extrusion Through Syringes." Diss., The University of Arizona, 2014. http://hdl.handle.net/10150/338734.

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The use of solid dispersions to formulate poorly water soluble drugs is a growing field in the pharmaceutical sciences. Hot-melt extrusion is a common method for producing dispersions. However, bench-top extruders require large amounts of powder to run and are inappropriate for early formulation screens. Plastic and glass syringes are readily available in most laboratories. 250 mg of drug-polymer blend is placed in a plastic syringe body that has the tip covered with a bent needle. The syringe is heated for 5 minutes and the extrudate is pushed through the syringe. Extrudates are characterized by differential scanning calorimetry and powder x-ray diffraction. Acetaminophen, griseofulvin, indomethacin, salicylamide, and sulfamethoxazole extruded with polyvinylpyrrolidone K12 match or exceed the performance of solvent evaporated controls. Glass syringes can be used when polymers have processing ranges above the melting point of the plastic syringes. Syringe extrusion is effectively demonstrated as a rapid process for early formulation screening.
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Scott, Jennifer. "Development, implementation and evaluation of harm reduction techniques for drug users." Thesis, Robert Gordon University, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.340071.

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Kroes, Gabriel. "An investigation of safety syringes in the prevention of needlestick injuries." Thesis, Stellenbosch : Stellenbosch University, 2001. http://hdl.handle.net/10019.1/52116.

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Thesis (MBA)--Stellenbosch University, 2001.
ENGLISH ABSTRACT: Daily more than 300 000 health care workers in South Africa are to a lesser or greater extent exposed to the risk of deadly viruses which can be transferred through neediestick injuries. It is estimated that currently 9,8 million people in South Africa are HIV positive. This high incidence of HIV has a great impact on the danger of infection from neediestick injuries. It is estimated that 44 000 neediestick injuries takes place annually in South Africa. Despite such a high risk there are currently few safety regulations or official efforts to prevent or determine the true impact and incidence of needlesticks in South Africa. This study project investigated the number of neediestick injuries that could potentially be prevented by the use of needles with safety features and estimated the ranges of benefits and costs of using such safety devices. With the financial constraints that are imposed on South African hospitals, infection control through the use of safety syringes makes economic sense. Prevention of infections is clearly far cheaper than cure.
AFRIKAANSE OPSOMMING: Daagliks word meer as 300 000 gesondheids personeel in Suid Afrika in 'n mindere of meerdere mate blootgestel aan die risiko van lewens gevaarlike viruse wat deur middel van naaldprik ongelukke oorgedra kan word. Hierdie risiko word spesifiek in Suid Afrika verhoog deur die hoë insidensie van HIV. Dit word beraam dat daar tans 9,8 miljoen mense in Suid Afrika is wat HIV positief is. Daar word beraam dat daar tans 44 000 naaldprik ongelukke per jaar in Suid Afrika plaasvind. Ten spyte van die hierdie hoë risko is daar tans min veiligheids regulasies of amptelike pogings om die omvang en voorkoming van naaldprik insidente te bepaal nie. Hierdie studie het die getal naaldprikke wat voorkom kan word deur die gebruik van veiligheids inspuitnaalde ondersoek en het die voordele en kostes van sulke veiligheidsmaatreëls beraam. Gegewe die finasiële druk wat ons tans in Suid Afrikaanse hospitale ondervind, is bewys dat die gebruik van veiligheids inspuitnaalde ekonomiese sin maak. Voorkoming op hierdie manier is bewys as 'n ver goedkoper opsie as nasorg.
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Lawson, Sarah, and Stacy Brown. "Stability of Oral Vitamin K Solutions Stored in Amber Plastic Syringes." Digital Commons @ East Tennessee State University, 2018. https://dc.etsu.edu/asrf/2018/schedule/102.

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Oral vitamin K is administered to patients who have very high INR lab values and are on warfarin therapy. Due to the inability of some patients to swallow tablets, and the commercial formulation of vitamin K being available only as a tablet or an injectable emulsion, it may be necessary to compound an oral liquid formulation. When compounding batches of oral solutions, it is sometimes convenient to measure the product in unit doses. In this project, we compared liquid vitamin K in sterile water (1mg/mL) verses liquid vitamin K in Ora-Sweet (1mg/mL) stored in amber plastic syringes. Vitamin K is light sensitive and is best stored in amber containers. Vitamin K is also lipophilic and may adsorb to the plastic syringes. In this study, we investigated the feasibility of bulk compounding oral vitamin K solutions, and aliquoting them for storage in amber plastic syringes. The Vitamin K in sterile water syringes were made by mixing 45 mL of sterile water and 5 ampules, each containing 10mg/mL of vitamin K emulsion, together in an amber glass bottle for a final concentration of 1mg/mL. Thirty 1mL plastic amber syringes were filled with the mixture, capped, and placed in the refrigerator. The same process was repeated using Ora-Sweet instead of sterile water to fill thirty more plastic amber syringes. Three syringes of vitamin K in sterile water mixture, three syringes of vitamin K in Ora-Sweet mixture, and one Vitamin K reference standard were all analyzed using HPLC-UV on the day of compounding, and at day 1, 2, 4, 7, 14, 21, 30, 60, and 90. If stability is defined as 90-110% active ingredient, then Vitamin K in sterile water is stable to fourteen days, 95.3±3.5% recovery, but some samples fell below 90% recovery after 14 days. By day ninety, the recovery in SWFI syringes was 84.2±8.9%. For vitamin K in Ora-Sweet, the within-day variability was very high due to limitations in drug dissolution; as such the average concentration was not consistently above 90%. On the day of compounding, the percent recovery in the Ora-Sweet syringes was 92.7±9.9%, despite 1 hour of stirring. In conclusion, the Vitamin K in sterile water mixture can be stored in refrigerated, amber oral plastic syringes for 14 days, but plastic amber syringes were not appropriate for storage of the Vitamin K in Ora-Sweet mixture.
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Huffman, Jessica, Stacy D. Brown, Paul O. Lewis, Sarah Lawson, Amanda P. Ogle, and Gina Peacock. "Comparative Stability of Oral Vitamin K Liquids Stored in Refrigerated Amber Plastic Syringes." Digital Commons @ East Tennessee State University, 2018. https://dc.etsu.edu/etsu-works/5323.

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The purpose of this study was to evaluate the stability of vitamin K1 oral liquids in Sterile Water for Injection when stored in amber glass bottles and amber plastic syringes under refrigerated conditions. Four 100-mL batches of vitamin K1 in Sterile Water for Injection were prepared in amber glass bottles to protect from light. One of the batches was divided into 1-mL aliquots, using amber plastic oral syringes, and capped. The prepared bottles and syringes were stored in a laboratory refrigerator. On each day of sampling, 1-mL aliquots were removed from each bottle and mixed with an equal volume of ethanol. Likewise, the contents of sample syringes were mixed with ethanol to achieve an assay concentration of 0.5 mg/mL. Recovery of vitamin K1 in the compounded samples was quantified against a United States Pharmacopeia reference standard. Quantification was achieved using a stability-indicating high-performance liquid chromatography with ultraviolent light detection method. Product stability is defined as 90% to 110% of the initial concentration. The percent recovery in the Sterile Water for Injection preparations in glass bottles remained above 90% for the 105-day duration of the study, but some samples stored in amber plastic syringes fell below 90% on day 21. Furthermore, a statistically significant difference (2-way ANOVA, P < 0.0001) emerged between syringes at day 0 and day 30, and this trend continued through the day 60, 90, and 105 samples. The only statistically significant difference found within the bottle-stored samples occurred on day 105 (versus zero, P = 0.0465), but the recovery on day 105 still exceeded 90%. Vitamin K1 in Sterile Water for Injection, stored in a refrigerated amber glass bottle, is stable for 105 days. This preparation can also be stored in amber plastic syringes, but this decreases the beyond-use date to 14 days.
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Lawson, Sarah, Paul O. Lewis, Gina Peacock, and Stacy D. Brown. "Comparative Stability of Oral Vitamin K Liquids Stored in Refrigerated Amber Plastic Syringes." Digital Commons @ East Tennessee State University, 2019. https://dc.etsu.edu/etsu-works/5322.

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Background:Compounded vitamin K oral liquids may be useful in some patient populations, or when an appropriate solid dosage form is not available. While vitamin K oral liquid is typically prepared with sterile water for injection (SWFI), other compounding agents may be more palatable.Objective:To evaluate stability of compounded vitamin K liquids in SWFI, Ora-Sweet, simple syrup, cherry syrup, and SyrPalta stored in amber plastic oral syringes.Methods:Five types of compounded vitamin K liquids were prepared in triplicate—Ora-Sweet, simple syrup, cherry syrup, SyrPalta, and SWFI without flavoring; aliquoted into amber plastic oral syringes; and stored in a laboratory refrigerator (4.9°C to 5.4°C). On study days, 3 syringes from each batch were removed, diluted to assay concentration, and compared with a freshly prepared US Pharmacopeia reference solution. The samples and reference were analyzed using a previously validated high-performance liquid chromatography–ultraviolet method. Product stability was defined as 90% to 110% labeled amount. Results were further compared using a 2-way ANOVA (analysis of variance; P = .05) with post hoc Tukey’s correction for multiple comparisons.Results:Vitamin K in SWFI, SyrPalta, and cherry syrup was stable for 21 days, 7 days, and 24 hours, respectively, under refrigeration in amber plastic oral syringes. Vitamin K in Ora-Sweet and simple syrup demonstrated high within-day variability and low potency. Statistically significant differences were detected between the SWFI formulation and all other vehicles.Conclusion:Vitamin K in SWFI is appropriate for longer-term storage of unit-dosed vitamin K; however, SyrPalta and cherry syrup may be used for short-term storage or immediate administration of vitamin K.
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Lawson, Sarah, Stacy D. Brown, Paul Lewis, and Gina Peacock. "Comparative Stability of Oral Vitamin K Solutions Stored in Refrigerated Amber Plastic Syringes." Digital Commons @ East Tennessee State University, 2018. https://dc.etsu.edu/etsu-works/5264.

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Purpose: Vitamin K1 (phytonadione) is a fat-soluble vitamin and an essential cofactor for the synthesis of clotting factors II, VII, IX, X, protein C, and protein S. Vitamin K antagonists deplete vitamin K reserves effectively preventing the synthesis of these clotting factors leading to anticoagulation. Overly excessive anticoagulation, as evidenced by INRs greater than 5, may necessitate vitamin K for reversal of warfarin depending on bleeding risk factors. For elevated INR without bleeding, the oral route is preferred. Orally administered vitamin K1 tablets are only supplied by a single manufacturer, and only available as a 5 mg tablet. Concerns with availability of this tablet, lack of dosing options for treatment requiring less than 5 mg, and delivery options for patients unable to swallow whole tablets have prompted the exploration of alternative dosing strategies using the 10 mg/mL injectable emulsion compounded into an oral liquid. The possibility of storing the oral liquid in unit-doses adds a layer of convenience, and is common practice in many hospital pharmacies. In this project, we compared oral liquid vitamin K1 in sterile water for injection (SWFI) to oral liquid vitamin K1 in Ora-Sweet, simple syrup, cherry syrup, and Syrpalta stored in amber plastic oral syringes. Methods: Batches of 1 mg/mL vitamin K1 were prepared in SWFI, Ora-Sweet, simple syrup, cherry syrup, and Syrpalta and drawn up by 1-mL aliquots into amber plastic oral syringes. Syringes were capped and stored in a laboratory refrigerator (4.9-5.4oC). for the duration of the study. On each study day (0, 1, 2, 4, 7, 14, 21, 30, 60, and 90), three syringes from each vehicle were removed, and the contents diluted with ethanol to achieve a 0.5 mg/mL assay concentration. Additionally, USP reference material was used on each study day to prepare a fresh 0.5 mg/mL reference solution. The samples and reference were analyzed using a previously validated HPLC-UV method. Results were compared using a 2-way ANOVA (p = 0.05) with post-hoc Tukey’s correction for multiple comparisons. Product stability was defined as 90-110% labeled amount. Results: Of the vehicles tested, SWFI was the most suitable vehicle for longer-term storage of unit-dosed vitamin K1. The 1 mg/mL vitamin K1 in SWFI, when stored in amber plastic oral syringes, remains within the acceptable 90 – 110% range for 21 days. The Syrpalta preparation demonstrated the next highest BUD of 7 days, with one syringe (2 injections) falling outside the 90% potency at the 14 day time point. Cherry syrup allowed for very limited stability, with a BUD of 24 hours. By the 48-hour time point, two of the three samples were below the 90% potency cutoff. For the vitamin K oral solutions prepared in simple syrup and Ora-Sweet, the recovery of vitamin K was not within acceptable limits, even on the day of compounding. The initial recovery for vitamin K in simple syrup was only 86.8%. Similarly, the preparation in Ora-Sweet, was not at acceptable potency on the day of compounding, (92.7 ± 9.9%). While the average recovery in Ora-Sweet exceeded 90%, the variability between samples suggests a lack of homogeneous distribution of drug through the vehicle. Statistically significant differences were detected between the SWFI preparation and all other vehicles in a 2-way ANOVA with Tukey’s multiple comparison post-test (p-value of 0.05). This difference was most pronounced between SWFI and Ora-Sweet and SWFI and simple syrup (both p < 0.0001). Cherry syrup was also vastly different from SWFI (p = 0.0002), and the difference between SWFI and Syrpalta was less pronounced, yet still significant (p = 0.0442). Conclusion: Vitamin K1 in sterile water and Syrpalta was stable for 21 days and 7 days, respectively, when stored in amber plastic syringes. Vitamin K1 in cherry syrup was only stable for 24 hours in the syringes. For vitamin K1 in Ora-Sweet and simple syrup, the within-day variability was very high due to limitations in drug dissolution; as such the average recovery was not consistently above 90%, even on the day of compounding. Statistically significant differences were detected between the SWFI formulation and all other vehicles. Several factors appear to affect the potency and stability of vitamin K1 in different vehicles. Because the stability of vitamin K1 oral solution differs between storage in amber glass bottles and oral syringes, vitamin K1 may have the potential to adsorb to polypropylene (PPE). The pH of the vehicle may contribute to degradation of vitamin K1, and the viscosity of the vehicle may affect the achievable potency of certain mixtures. The viscosity of the mixture also appears to affect maintenance of a homogenous mixture, but the presence of alcohol in the vehicle may help aid in solubilizing the vitamin K1 in Syrpalta. Vitamin K1 in SWFI appears to be the most suitable vehicle for longer-term storage of unit-dosed vitamin K, but Syrpalta and cherry syrup may also be appropriate for more immediate use.
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Brown, Stacy D., Paul O. Lewis, Loren M. Kirk, and Yao Luu. "Stability of Commercially-Available Grape and Compounded Cherry Oral Vancomycin Preparations Stored in Syringes and Cups." Digital Commons @ East Tennessee State University, 2015. https://dc.etsu.edu/etsu-works/5275.

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Kirk, Loren Madden, Paul O. Lewis, Yao Luu, and Stacy D. Brown. "Stability of Commercially Available Grape and Compounded Cherry Oral Vancomycin Preparations Stored in Syringes and Cups." Digital Commons @ East Tennessee State University, 2016. https://dc.etsu.edu/etsu-works/5312.

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The purpose of this study was to evaluate the stability of two preparations of vancomycin oral solution in two different storage containers, capped amber oral-dosing syringes and heat-sealed oral-dosing cups, stored under refrigerated conditions. Commercially available grape-flavored vancomycin oral preparation and compounded vancomycin for intravenous use in cherry syrup oral preparation were divided into 5-mL aliquots into heat-sealed plastic dosing cups and capped oral-dosing syringes. All samples were stored under refrigeration (2°C to 8°C) and evaluated at days 0, 3, 7, 14, 30, 60, and 90. For each evaluation, samples were visually inspected and analyzed for potency using a stability-indicating high-performance liquid chromatographic method with ultraviolet detection. Over the study period, at least 90% of the initial concentrations for the preparation and the product in both storage containers were retained at 60 days. The commercially available oral vancomycin further demonstrated stability within 90% out to 90 days in the syringe and the unit-dose cups. Visual inspection revealed no changes in the grape-flavored vancomycin oral preparation, but a detectable red-dye precipitate could be seen in the crevices of the dosing cups from the vancomycin in cherry syrup oral preparation after 60 days. Commercially available grape-flavored vancomycin oral preparation was stable up to 90 days, and com- pounded vancomycin for intravenous use in cherry syrup oral preparation maintained stability for 60 days when dispensed in capped amber polypropylene oral-dosing syringes and heat-sealed plastic dosing cups when stored at refrigerated conditions.
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Stellman, Jeffrey Taylor. "Production, development, and characterization of plastic hypodermic needles." Thesis, Atlanta, Ga. : Georgia Institute of Technology, 2009. http://hdl.handle.net/1853/29748.

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Thesis (M. S.)--Mechanical Engineering, Georgia Institute of Technology, 2009.
Committee Chair: Dr. Jonathan S. Colton; Committee Member: Dr. Mark R. Prausnitz; Committee Member: Dr. Rudolph L. Gleason. Part of the SMARTech Electronic Thesis and Dissertation Collection.
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Books on the topic "Syringes"

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National Institutes of Health (U.S.). Office of Clinical Center Communications., ed. Accidental needle stick: How to avoid it-- what to do if it happens--. [Bethesda, Md.?: Clinical Center Communications, Clinical Center, NIH, 1987.

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Network, Canadian HIV/AIDS Legal, ed. Sticking points: Barriers to access to needle and syringe programs in Canada. Toronto: Canadian HIV/AIDS Legal Network = Réseau juridique canadien VIH/sida, 2007.

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New York (State). AIDS Advisory Council. Report on needle exchange programs and deregulation of needles and syringes. [Albany, N.Y.?: The Council, 1996.

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(India), National AIDS Control Organization. Guidelines on safe disposal of used needles and syringes in the context of targeted intervention for injecting drug users. New Delhi: National AIDS Control Organisation, Dept. of AIDS Control, Ministry of Health and Family Welfare, Govt. of India, 2009.

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Kristvik, Ellen. Drums and syringes: Patients and healers in combat against TB bacilli and hungry ghosts in the hills of Nepal. Kathmandu: Educational Enterprises, 1999.

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Lowen, Lauri D. Residential syringe collection by waste haulers: A disposal option for diabetics. Bellevue, Wash: Washington Dept. of Ecology, 1993.

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Lowen, Lauri. Residential syringe collection by waste haulers: A disposal option for diabetics. Bellevue, Wash: Washington Dept. of Ecology, 1993.

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Scott, Burris, and American Bar Association. AIDS Coordinating Committee., eds. Deregulation of hypodermic needles and syringes as a public health measure: A report on emerging policy and law in the United States. Washington, D.C: American Bar Association, AIDS Coordination Project, 2001.

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Rajendran, Meera. Developing a nationally consistent data set for needle and syringe programs. Canberra: Australian Institute of Health and Welfare, 2007.

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Rajendran, Meera. Developing a nationally consistent data set for needle and syringe programs. Canberra: Australian Institute of Health and Welfare, 2007.

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Book chapters on the topic "Syringes"

1

Swift, Robert. "Prefilled Syringes for Biopharmaceuticals." In Formulation and Process Development Strategies for Manufacturing Biopharmaceuticals, 897–916. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2010. http://dx.doi.org/10.1002/9780470595886.ch36.

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Kuehn, Kerry. "Syringes, Siphons and Suckling Infants." In Undergraduate Lecture Notes in Physics, 199–216. New York, NY: Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4939-1366-4_16.

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Fitzgerald, John L. "Syringes, Metonymy, Global Fear and News." In Framing Drug Use, 30–54. London: Palgrave Macmillan UK, 2015. http://dx.doi.org/10.1057/9781137482242_4.

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Koulov, Atanas. "Special Topics in Analytics of Pre-filled Syringes." In Challenges in Protein Product Development, 225–33. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-90603-4_10.

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Sandul, Amy L., and Veda B. Moore. "Harm Reduction: Tipping the Balance Toward Treatment and Recovery." In Public Health Ethics Analysis, 141–52. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-92080-7_10.

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AbstractOpioid use has risen dramatically over the past 40 years. In response, federal programs and policies aimed at decreasing supply of prescription opioids have stabilized excessive prescribing. Unintended consequences of limiting the quantity of prescription opioids in the population has resulted in increased use of illicit drugs and opened a pathway of transition from misuse of pills to injection of heroin and use of potent formulations of cheap, synthetic opioids such as fentanyl. Harm reduction interventions function at the community level to provide health benefits and avoidance of harm to persons engaging in illicit and injection drug use. The Consolidated Appropriations Act of 2016 gives states, local, tribal, and territorial health departments the opportunity to use federal money to support a comprehensive set of harm reduction services. Critics of harm reduction strategies argue that formalizing and legalizing certain activities creates the perception that communities and local authorities are sanctioning or encouraging illicit/illegal drug use. Syringe services programs that provide clean needles and syringes so people who inject drugs are not forced to share or reuse injection equipment, are often at the heart of such controversy. This story addresses tensions that exist in communities grappling with harm reduction approaches to opioid and injection drug use.
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Han, T., J. Hah, S. Kim, and Jack J. Yoh. "Light Syringes Based on the Laser Induced Shock Wave." In 28th International Symposium on Shock Waves, 819–25. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-25685-1_124.

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Rodriguez, Ricardo Luis, and Alexandra Condé-Green. "Negative Pressures Generated by Different Caliber Syringes Used for Liposuction." In Liposuction, 133–37. Berlin, Heidelberg: Springer Berlin Heidelberg, 2016. http://dx.doi.org/10.1007/978-3-662-48903-1_12.

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Honkoop, Margot, Armagan Albayrak, Ruud Balkenende, Nicole Hunfeld, and Jan Carel Diehl. "Reducing the Environmental Impact of Syringes at the Intensive Care Unit." In Convergence: Breaking Down Barriers Between Disciplines, 225–34. Cham: Springer Nature Switzerland, 2023. http://dx.doi.org/10.1007/978-3-031-32198-6_21.

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Li, Ru-Jie, Yi-Han Wang, Jie Cai, Jie Liu, Zhi-Ping Xie, and Christian Staehelin. "In Vivo Analysis of Rhizosphere Enzyme Activities by the Use of Plastic Syringes." In Methods in Rhizosphere Biology Research, 19–25. Singapore: Springer Singapore, 2019. http://dx.doi.org/10.1007/978-981-13-5767-1_2.

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Ghodrat, Maryam, and Bijan Samali. "Thermodynamic Analysis of Incineration Treatment of Waste Disposable Syringes in an EAF Steelmaking Process." In Energy Technology 2018, 77–88. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-72362-4_7.

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Conference papers on the topic "Syringes"

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Van Gelder, T., A. Lalmohamed, K. Dorst-Mooiman, J. Dekker, M. Schinkel, M. Sikma, E. Uijtendaal, and T. Egberts. "3PC-004 Drug waste of ready-to-administer syringes in the intensive care unit: aseptically prepared syringes versus prefilled sterilised syringes." In 28th EAHP Congress, Bordeaux, France, 20-21-22 March 2024. British Medical Journal Publishing Group, 2024. http://dx.doi.org/10.1136/ejhpharm-2024-eahp.61.

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Palma, E. "Patients Safety: Labeling Syringes in an Endoscopy Clinic." In ESGE Days 2024. Georg Thieme Verlag KG, 2024. http://dx.doi.org/10.1055/s-0044-1783154.

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Gomez Sanchez, MT, R. Gazquez Perez, FD Fernandez Gines, M. Sanchez Valera, D. Gamez Torres, and MG Diaz Lopez. "3PC-002 Stability of tenecteplase syringes after fractionation." In 28th EAHP Congress, Bordeaux, France, 20-21-22 March 2024. British Medical Journal Publishing Group, 2024. http://dx.doi.org/10.1136/ejhpharm-2024-eahp.59.

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Lin, Robert, Maulik Patel, and Abraham Lee. "Improving Cell Loading Efficiency Into Microfluidic Devices Using LCATs." In ASME 2010 5th Frontiers in Biomedical Devices Conference. American Society of Mechanical Engineers, 2010. http://dx.doi.org/10.1115/biomed2010-32076.

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Due to the nature of the interfaces used by microfluidic devices — syringes, syringe pumps, and tubing, delivering cells into microfluidic devices faces some practical challenges. Specifically, the unwanted settling and adhesion of cells onto various surfaces can significantly impact the effective transport of cells into the device.[1] One particular challenge is the cell settling that occurs inside devices and especially at the inlet connection port. As most tubing connections are vertical, the cell suspension moves downwards into the device before making a 90° turn into the fluidic channels. This orientation causes cells to settle, clump and adhere to surfaces around the inlet port and eventually causes clogging that prevent more cells from entering the microfluidic channels.
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Fernández-Ginés, FD, S. Garcia-Muñoz, TB Rodríguez-Cuadros, F. Sierra-Garcia, and E. Molina Cuadrado. "PP-009 Stability of intraveous injection of decitabine stored in polyethylene syringes." In 22nd EAHP Congress 22–24 March 2017 Cannes, France. British Medical Journal Publishing Group, 2017. http://dx.doi.org/10.1136/ejhpharm-2017-000640.456.

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Chaïb, S., F. Hallouard, C. Darcissac, P. Chennell, V. Sautou, and M. Fraysse. "3PC-039 Stability study of (99MTC)dotatoc and (68GA)dotatoc in syringes." In 24th EAHP Congress, 27th–29th March 2019, Barcelona, Spain. British Medical Journal Publishing Group, 2019. http://dx.doi.org/10.1136/ejhpharm-2019-eahpconf.120.

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DelSpina, Brandon, Yu Zhang, and Yue Wang. "A Benchtop Robot and Automation Solution for Prefilled Syringes in Pharmaceutical Manufacturing." In 2021 IEEE 17th International Conference on Automation Science and Engineering (CASE). IEEE, 2021. http://dx.doi.org/10.1109/case49439.2021.9551535.

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Li, Haiwang, Teck Neng Wong, and Nam-Trung Nguyen. "Electrohydrodynamic and Shear-Stress Interfacial Instability of Two Streaming Viscous Liquid Inside a Microchannel for Normal Electric Fields." In ASME 2011 9th International Conference on Nanochannels, Microchannels, and Minichannels. ASMEDC, 2011. http://dx.doi.org/10.1115/icnmm2011-58089.

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The electrohydrodynamic and shear-stress instability of the interface between two viscous fluids with different electrical properties under constant flowrates in microchannel is analytically and experimentally investigated. In analytical model, the two-layer system is subjected to an electric field normal to the interface between the two fluids; the electric field, surface charge and fluid dynamic are coupled only at the interface. In the experiments, two immiscible fluids, aqueous NaHCO3 (high electrical mobility fluid) and Poly (dimethylsiloxane) (low electrical mobility fluid) are pushed into the PMMA microchannel using syringes and syringe pump. The normal electric field is added to the aqueous NaHCO3 using high voltage power supply; the perturbation electric field are added using a function generator and a power amplifier. The results showed that the electric fields can induce the instability of fluids in microchannel; the increasing of viscosity and flowrates has a stabilizing effect to the flow; but increasing of thickness has a destabilizing effect to the flow. The results also show that the analytical solution has a good agreement with the experimental results.
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Nair, Gokul, Michael Levin, and Sudesh Sivarasu. "Design and Verification of a Reloadable Adrenaline Auto-Injector for Intramuscular Injections." In 2018 Design of Medical Devices Conference. American Society of Mechanical Engineers, 2018. http://dx.doi.org/10.1115/dmd2018-6944.

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Anaphylaxis is a severe allergic reaction when a patient is exposed to an antigen to which they have become hypersensitive. Exposure to these antigens results in the release of mediators from mast cells in the body, causing inflammation of critical organ systems. Without immediate treatment, it can lead to patient mortality within 15 minutes. To increase the probability of patient survival, a dose of adrenaline must be administered. There are several routes of administration, but the use of an Adrenaline Auto Injector is the safest, quickest and most efficient route. An Adrenaline Auto-Injector (AAI) is an injection device that delivers adrenaline to the deep muscle tissue of the body, preferably via the vastus lateralis muscle (as the rate of absorption is more effective than other injection sites such as the deltoid, gluteus maximus etc). Adrenaline Auto-Injectors are preferable to syringes, or prefilled syringes as they are easier to use, and can be used by people that are not medically trained. They can also be used in highly stressful situations without much risk of injury.
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Beld, K., S. Van Berkel, R. Wijnsma, K. Taxis, and E. Frijlink. "3PC-043 New formulation of norepinephrine solution in prefilled cyclic olefin sterilised syringes." In 24th EAHP Congress, 27th–29th March 2019, Barcelona, Spain. British Medical Journal Publishing Group, 2019. http://dx.doi.org/10.1136/ejhpharm-2019-eahpconf.124.

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Reports on the topic "Syringes"

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Aslim, Erkmen, Wei Fu, Erdal Tekin, and Shijun You. From Syringes to Dishes: Improving Food Security through Vaccination. Cambridge, MA: National Bureau of Economic Research, March 2023. http://dx.doi.org/10.3386/w31045.

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Caroline Keroack, Caroline Keroack. Mosquitoes as Flying Syringes: The Solution to Rapid Zika Monitoring. Experiment, February 2016. http://dx.doi.org/10.18258/6657.

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Boaden, Dr Bill. Syringe labelling in anaesthesia and critical care areas: review 2022. Association of Anaesthetists of Great Britain and Ireland, September 2022. http://dx.doi.org/10.21466/g.sliaacc.2022.

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This document replaces the Association of Anaesthetists’ previous guidance1 on this topic, following the publication of BS ISO 26825:2020. BS ISO 26825:2020 is the second edition of the standard for user-applied labels for syringes containing drugs used in anaesthesia. It technically revises, cancels and replaces the 2008 first edition. It gives requirements for labels attached to syringes so that the contents can be identified during anaesthesia and covers the colour, size, design and general properties of the label and the typographical characteristics of the wording for the drug name. Its purpose is solely for use in anaesthesia and as such covers a range of core drug groups. It is acknowledged that these labels may find a use in other critical care areas. The main technical reason for the revision of BS ISO 26825 was to improve the colour, size and design of the labels. Several labels were revised to take account of comments made regarding their clarity and possibility of confusion in use.
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Birenzvige, Amnon, and Joseph P. Krasnec. Method for Sampling of Methyl Salicylate Vapor in Air Using Passivated Stainless Steel Syringes and Analysis by Gas Chromatography. Fort Belvoir, VA: Defense Technical Information Center, October 1987. http://dx.doi.org/10.21236/ada187838.

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Bagijn, Marloes, Joel Uzzan, Adam Mapani, Oliver Cox, and Insaf Saffar. Healthcare resource use and clinical outcomes and experiences with different pre-filled syringes for intravitreal administration of anti-VEGF treatments versus vials: A systematic review protocol. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, February 2024. http://dx.doi.org/10.37766/inplasy2024.2.0007.

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Meek, Dr Tim. Syringe labelling in critical care areas review. The Association of Anaesthetists of Great Britain and Ireland, November 2016. http://dx.doi.org/10.21466/g.sliccar.2016.

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Coleman, C. J. Development of Syringe/Bottle Hybrids for Sampling Slurries. Office of Scientific and Technical Information (OSTI), January 1998. http://dx.doi.org/10.2172/586857.

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Quigley, Kevin, Vakhtang Makarashvili, Sergey Chemerisov, George Vandegrift, Peter Tkac, Ron Schluter, and James Harvey. Irradiation Stability of Syringe and Valve Controllers of RadioGenix{TM} System. Office of Scientific and Technical Information (OSTI), August 2014. http://dx.doi.org/10.2172/1155047.

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Blake, Butch O. Testing and Evaluation of the Baxter, Inc., Model AS5O Syringe Pump. Fort Belvoir, VA: Defense Technical Information Center, February 2000. http://dx.doi.org/10.21236/ada377353.

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Chandrashekhar P. Joshi and Vincent L. Chiang. Improved Wood Properties Through Genetic Manipulation: Engineering of Syringyl Lignin in Softwood Species Through Xylem-Specific Expression of Hardwood Syringyl Monolignol Pathway Genes. Office of Scientific and Technical Information (OSTI), January 2009. http://dx.doi.org/10.2172/946605.

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