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Dissertations / Theses on the topic 'Systemic lupus erythematoses'

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Published: 4 June 2021

Last updated: 28 July 2025

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1

Teh, Lee-Suan. "Neuropsychiatric systemic lupus erythematosus." Thesis, University of Aberdeen, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.240703.

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Neuropsychiatric (NP) symptoms are relatively common in patients with SLE. The diverse and dramatic clinical presentations, the unclear pathogenesis, the lack of diagnostic test/s and uncertainties about the optimal management are some problems facing a clinician. When serum anti P antibodies were claimed to be highly correlated to lupus psychosis, this needed confirmation. An ELISA for measuring anti P antibodies was developed and validated. The prevalence of anti P antibodies was determined in different patient groups in a large retrospective study. Although anti P antibodies were highly spe

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2

Brown, Aaron Clifford. "Molecular and Phenotypic Characterization of the Y-Linked Autoimmune Accelerator (YAA)." Fogler Library, University of Maine, 2007. http://www.library.umaine.edu/theses/theses.asp?highlight=1&Cmd=abstract&ID=BMB2007-011.

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3

Bernatsky, Sasha. "Malignancy in systemic lupus erythematosus." Thesis, McGill University, 2001. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=32761.

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Objectives. (1) To estimate cancer incidence in systemic lupus erythematosus (SLE) as compared to the general population. (2) To estimate the sensitivity and specificity of methods of cancer ascertainment. (3) To determine the prevalence of malignancy risk factors in SLE. Methods. (1) We determined the incidence of malignancy in the Montreal General Hospital (MGH) lupus cohort, through linkage with the Quebec tumor registry. Standardized incidence ratios (SIRS) were generated, using Quebec population rates. In addition, a meta-analysis was performed by pooling data from eight cohort studies of

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4

Clarke, Alexander James. "Autophagy in Systemic Lupus Erythematosus." Thesis, King's College London (University of London), 2015. http://kclpure.kcl.ac.uk/portal/en/theses/autophagy-in-systemic-lupus-erythematosus(1e5a4a5e-99f7-456e-bcb4-634a4e3fd986).html.

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Autophagy has emerged as a critical homeostatic mechanism in lymphocytes, influencing proliferation and differentiation. I sought to explore the role of autophagy in the pathogenesis of human and murine lupus, a disease in which B cells are critical effectors of pathology. Autophagy was assessed using multiple techniques in NZB/W and control mice, and in patients with SLE compared to healthy controls. I evaluated the phenotype of the B cell compartment in Vav-Atg7-/- mice in vivo, and examined human and murine plasmablast formation following inhibition of autophagy. I found activation of autop

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5

Fan, Hiu-yi Rosie. "Cost of systemic lupus erythematosus in Hong Kong /." View the Table of Contents & Abstract, 2005. http://sunzi.lib.hku.hk/hkuto/record/B32020636.

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6

Wong, Kee-lam, and 黃基林. "Systemic lupus erythematosus in Hong Kong." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1990. http://hub.hku.hk/bib/B31981410.

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7

Peschken, Christine A. "Systemic lupus erythematosus in Manitoba Aboriginals." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape9/PQDD_0019/MQ55086.pdf.

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8

Svenungsson, Elisabet. "Cardiovascular disease in systemic lupus erythematosus /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-501-8.

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9

Russell, Andrew Ian. "Genetic predisposition to systemic lupus erythematosus." Thesis, Imperial College London, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.406513.

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10

Li, Hei Philip, and 李曦. "Subphenotype stratification in systemic lupus erythematosus." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hub.hku.hk/bib/B48334765.

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Subsets of systemic lupus erythematosus (SLE) patients with distinct patterns of disease manifestations and autoantibody production have been reported, but seldom have these two phenomena been analysed together. Cluster analysis was performed on 1928 Chinese SLE patients based on autoantibody profile and the frequencies of various clinical manifestations were compared between each cluster. Separate association analyses between individual autoantibodies and clinical manifestations, as well as between clinical manifestations, were also performed. This study identifies three separate autoantib

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11

Courtney, Philip. "Leukocyte apoptosis in systemic lupus erythematosus." Thesis, Queen's University Belfast, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.326415.

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12

Chan, Madelynn Tsu-Li. "Serological biomarkers in systemic lupus erythematosus." Thesis, University of Bath, 2013. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.607470.

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Background: Systemic lupus erythematosus (SLE) is a multi-system autoimmune disease characterised by autoantibody production and variable clinical features, ranging from mild to severe disease. Patients with SLE are at increased risk of developing accelerated atherosclerosis. Biomarkers have potential utility in SLE as markers of disease or predictors of future clinical events and mortality. Objective The aim of this thesis was to identify serological biomarkers predictive for erosive arthritis (EA), cardiovascular events (CVEs), mortality and subclinical atherosclerosis in SLE. Methods: In ch

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13

Niemela-Waller, Kirsi (Kirsi M. ). "Cognitive Dysfunction in Systemic Lupus Erythematosus." Thesis, University of North Texas, 1997. https://digital.library.unt.edu/ark:/67531/metadc278952/.

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The purpose of the study was to determine the point prevalence of cognitive dysfunction in patients with systemic lupus erythematosus (SLE) and to investigate its association with corticosteroids and depression. The severity of dysfunction and the pattern of cognitive changes were examined. This study hypothesized that cognitive dysfunction is common in SLE and many previous studies have underestimated its prevalence, partially due to using limited neuropsychological batteries and insensitive test instruments. It was further hypothesized that the pattern of cognitive changes in SLE patients wi

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14

Aronson, Ingrid. "The cytopenias in systemic lupus erythematosus." Master's thesis, University of Cape Town, 1989. http://hdl.handle.net/11427/26344.

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15

Scalzi, Lisabeth Victoria. "Subclinical Atherosclerosis in Systemic Lupus Erythematosus." Case Western Reserve University School of Graduate Studies / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=case1212695307.

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16

Lee, Loretta Lok-Yan. "Immune Profiling of Systemic Lupus Erythematosus." Thesis, The University of Sydney, 2015. http://hdl.handle.net/2123/14440.

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Studies in animal models and lupus patients suggest several mechanisms driving the loss of B cell regulation in Systemic Lupus Erythematosus (SLE). The first mechanism involves the overexpression of B cell activating factor and the second is driven by follicular T helper (Tfh) cells. Monocytes have been implicated in the pathogenesis of SLE through recognition of immune complexes containing TLR-binding self-antigens. The overall decrease of NK cells and increase of CD56briCD16- NK cells could further promote immune dysregulation in SLE. Our aim was to determine whether these abnormalities co-e

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17

Rupanagudi, Khader Valli. "Immunoregulatory proteases in systemic lupus erythematosus and lupus nephritis." Diss., Ludwig-Maximilians-Universität München, 2013. http://nbn-resolving.de/urn:nbn:de:bvb:19-162652.

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18

Lövgren, Tanja. "Endogenous type I interferon inducers in systemic autoimmune diseases /." Uppsala : Acta Universitatis Upsaliensis, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7181.

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19

Liu, Tiefu. "The role of interleukin-12 in the pathogenesis of human systemic lupus erythematosus /." Hong Kong : University of Hong Kong, 1998. http://sunzi.lib.hku.hk/hkuto/record.jsp?B20381505.

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20

Druley, Jennifer A. "Couples Coping with Wives' Systemic Lupus Erythematosus." Kent State University / OhioLINK, 1995. http://rave.ohiolink.edu/etdc/view?acc_num=kent1507726194610255.

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21

Strout, Stephen Lewis. "Association between systemic lupus erythematosus and periodontitis." [Gainesville, Fla.] : University of Florida, 2004. http://purl.fcla.edu/fcla/etd/UFE0004857.

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Thesis (M.S.)--University of Florida, 2004.<br>Typescript. Title from title page of source document. Document formatted into pages; contains 43 pages. Includes Vita. Includes bibliographical references.

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22

Casanova, Francesco. "maximal oxygen consumption in systemic lupus erythematosus." Thesis, Bangor University, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.531058.

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23

Mok, Chi-chiu, and 莫志超. "Gender, sex hormones and systemic lupus erythematosus." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2002. http://hub.hku.hk/bib/B29780147.

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24

Mak, Anselm, and 麥為憲. "Major organ damage in systemic lupus erythematosus." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B4765739X.

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Systemic lupus erythematosus (SLE) is an autoimmune disorder characterized by disease flares and damage accrual. The increased longevity allows SLE patients to accrue damage which has retarded their survival improvement since the 1980s. In the first study of this thesis, meta-analyses of observational studies revealed that renal and neuropsychiatric damage has been adversely affecting the survival of lupus patients in the past fifty years. While confirmatory studies are required, targeting at renal and neuropsychiatric involvement early might hopefully further improve the survival of SLE pati

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25

Fraser, Louise. "Immunoglobulin light chains in Systemic Lupus Erythematosus." Thesis, King's College London (University of London), 2013. https://kclpure.kcl.ac.uk/portal/en/theses/immunoglobulin-light-chains-in-systemic-lupus-erythematosus(759b46c1-24bc-427d-8b25-8987eec6f61f).html.

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Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease of elusive origin and characterised by polyclonal B cell hyperactivity and the production of pathogenic antibodies targeting self DNA and nucleoproteins. Clinical manifestations of SLE are highly heterogeneous and include multisystem inflammation of connective tissue and vasculitis of the central nervous system (CNS). SLE is known to have genetic associations, and is widely acknowledged to involve a profound breakdown in immune tolerance. The aim of this project was to identify whether defects in early B cell development that a

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26

Chen, Lingyan. "Genetics and epigenetics in systemic lupus erythematosus." Thesis, King's College London (University of London), 2018. https://kclpure.kcl.ac.uk/portal/en/theses/genetics-and-epigenetics-in-systemic-lupus-erythematosus(6257f5a2-eef5-4a55-9fb4-17bceed2c7d1).html.

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Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease associated with a wide range of clinical features involving different organs and the prognosis is also highly variable. It is a complex genetic trait in which more than 80 susceptibility loci show robust genetic association with disease risk. Firstly, I preformed eQTL mapping, incorporating co-localization analysis of GWAS in the functional immune cells, in order to identify likely causal genes. The results indicate that eQTLs present in a diverse set of immune cells, encompassing both the innate and adaptive immun

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27

Vieson, Miranda Diane. "Selective HDAC6 Inhibition in Systemic Lupus Erythematosus." Diss., Virginia Tech, 2017. http://hdl.handle.net/10919/74872.

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Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterized by abnormalities in multiple components of the immune system resulting in progressive damage to multiple organs. Current treatments for SLE are often intensive and result in side effects and the potential for continued flares and progression of disease. Histone deacetylase (HDAC) enzymes control multiple cellular functions by removing acetyl groups from lysine residues in various proteins. HDAC inhibitors have been investigated as a potential treatment for SLE with promising results, however selective HDAC6

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28

Ruth, Natasha M. "Childhood-Onset Systemic Lupus Erythematosus: Neurocognitive Function." Cincinnati, Ohio : University of Cincinnati, 2006. http://www.ohiolink.edu/etd/view.cgi?acc_num=ucin1148060762.

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Thesis (M.S.)--University of Cincinnati, 2006.<br>Advisor: Dr. Kim N. Dietrich. Title from electronic thesis title page (viewed June 3, 2009). Includes abstract. Keywords: Systemic Lupus Erythematosus; Neurocognitive Function; ANAM. Includes bibliographical references.

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29

Mok, Chi-chiu. "Gender, sex hormones and systemic lupus erythematosus /." Hong Kong : University of Hong Kong, 2002. http://sunzi.lib.hku.hk/hkuto/record.jsp?B25943479.

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30

Denton, Fiona. "Illness Self-Schema in Systemic Lupus Erythematosus." Thesis, The University of Sydney, 2003. http://hdl.handle.net/2123/596.

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Systemic lupus erythematosus (SLE) is a relatively rare autoimmune disease with no known aetiology or cure. In addition to numerous physical symptoms, those living with SLE have also been shown to experience significant emotional and psychosocial difficulties. There has been little psychological research into SLE despite the rapidly increasing interest in health psychology and quality of life issues over the last two decades. One such issue that has commanded particular attention is that of cognitive bias in individuals with chronic pain and/or chronic illness. Cognitive bias toward illness-re

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31

Denton, Fiona. "Illness Self-Schema in Systemic Lupus Erythematosus." University of Sydney. Psychology, 2003. http://hdl.handle.net/2123/596.

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Systemic lupus erythematosus (SLE) is a relatively rare autoimmune disease with no known aetiology or cure. In addition to numerous physical symptoms, those living with SLE have also been shown to experience significant emotional and psychosocial difficulties. There has been little psychological research into SLE despite the rapidly increasing interest in health psychology and quality of life issues over the last two decades. One such issue that has commanded particular attention is that of cognitive bias in individuals with chronic pain and/or chronic illness. Cognitive bias toward illness-re

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32

Barkhuizen, Andre. "Pulmonary hypertension in systematic lupus erythematosus." Thesis, University of Cape Town, 1994. http://hdl.handle.net/11427/25896.

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33

McKinney, Eoin Fergal. "Gene expression profiling in systemic vasculitis and systemic lupus erythematosus." Thesis, University of Cambridge, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.609786.

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34

Victorin, Sofia. "Livskvalitet vid systemisk lupus erythematosus (SLE)." Thesis, Mid Sweden University, Department of Health Sciences, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:miun:diva-260.

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35

Tench, Colin Mark. "The study of fatigue in systemic lupus erythematosus." Thesis, Queen Mary, University of London, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.406905.

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36

Reefman, Esther. "Apoptotic cell clearance in Systemic Lupus Erythematosus (SLE)." [S.l. : [Groningen : s.n.] ; University Library Groningen] [Host], 2006. http://irs.ub.rug.nl/ppn/297988956.

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37

Fan, Hiu-yi Rosie, and 范曉怡. "Cost of systemic lupus erythematosus in Hong Kong." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2005. http://hub.hku.hk/bib/B45012817.

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38

Leung, Wai-hin, and 梁瑋軒. "Neurogenesis in animal model of systemic lupus erythematosus." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hdl.handle.net/10722/209497.

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Systemic Lupus Erythematosus (SLE) is an autoimmune disease which is characterized by high level of autoantibody detected in the body. This disease is female predominant with a male to female ratio 1: 9. SLE could cause damage to different organ systems and central nervous system is one of them. Patients diagnosed with SLE could suffer from psychiatric problems like cognitive dysfunction, depression and anxiety. Neurogenesis refers to the process by which new neurons are generated. Although it has been widely reported that neurogenesis could be enhanced under pathological conditions such as

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39

Zandi, Michael Surena. "Biomarkers and immunotherapy of neuropsychiatric systemic lupus erythematosus." Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.608051.

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40

Quinlan, C. T. "Cardiovascular morbidity in juvenile-onset systemic lupus erythematosus." Thesis, University College London (University of London), 2015. http://discovery.ucl.ac.uk/1466735/.

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Cardiovascular disease (CVD) is a leading cause of mortality in adults with systemic lupus erythematosus (SLE). As children with conditions such as chronic kidney disease have been shown to have a risk of CVD similar to their adult counterparts, clinicians have become concerned that paediatric patients with SLE are at increased risk of CVD. The aim of this project was to examine the vascular phenotype of a British paediatric population with SLE and gain mechanistic insights into this process. Structural changes in vessels were measured using carotid intima media thickness (cIMT) and function w

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41

Watson, Louise. "Renal biomarkers in juvenile-onset systemic lupus erythematosus." Thesis, University of Liverpool, 2012. http://livrepository.liverpool.ac.uk/10293/.

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Background: Juvenile-onset Systemic Lupus Erythematosus (JSLE) is a rare, but severe, autoimmune condition with lupus nephritis (LN) occurring in up to 80% of patients and predisposing to an increased mortality. Aims/Objectives: As part of the UK JSLE Cohort Study this study aimed to identify whether standard and/or novel biomarkers are useful for monitoring LN and to assess whether novel urine biomarkers are released from the podocyte (kidney epithelial cell). Method/Results: A prospective translational study encompassing a clinical cross sectional biomarker analysis, a longitudinal observati

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42

Chiewchengchol, Direkrit. "Neutrophil function in juvenile systemic lupus erythematosus (JSLE)." Thesis, University of Liverpool, 2013. http://livrepository.liverpool.ac.uk/14115/.

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Objectives: This project aimed to investigate the abnormal neutrophil functions in terms of cell survival, phagocytosis, ROS production and chemotaxis in JSLE patients. Furthermore, factors that could affect normal neutrophil functions (such as patient sera, recombinant human cytokines and commonly-used medications) were investigated. Methods: Neutrophils and sera were isolated from whole blood of JSLE patients, healthy juvenile controls and healthy adult controls. Neutrophils from healthy adult controls were incubated with 10% serum from either JSLE patients or juvenile controls. Different re

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43

Hunnankul, Saowalak. "Analysis of antibody data in systemic lupus erythematosus." Thesis, London School of Hygiene and Tropical Medicine (University of London), 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.536668.

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44

Lynch, Kimberly Vandermark. "Narratives of Men Living with Systemic Lupus Erythematosus." ScholarWorks, 2017. https://scholarworks.waldenu.edu/dissertations/3704.

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While systemic lupus erythematosus (SLE) has been traditionally viewed as a woman's disease, SLE impacts men as well. Although most research on SLE has concentrated on how it affected women, little is known about how it impacts men. The purpose of this phenomenological study was to examine how men who live with SLE perceive its psychological impact. Using the lens of the biopsychological theory, common themes were examined pertaining to how men with SLE perceive the impact that SLE has on their cognitive and emotional functioning. Data were collected via interviews with 9 men with SLE, and the

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45

Gröndal, Gerður. "Systemic lupus erythematosus : pathogenesis and genetics with special reference to multicase families /." Stockholm, 2001. http://diss.kib.ki.se/2001/91-628-4943-3/.

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46

Ng, Ping. "STAT4 and BLK, but not PXK, are associated with Systemic lupus erythematosus (SLE) in Hong Kong Chinese." Click to view the E-thesis via HKUTO, 2008. http://sunzi.lib.hku.hk/hkuto/record/B4150852X.

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47

Culligan, Gary Arthur. "An investigation of the lupus anticoagulant and anticardiolipin antibodies in systemic lupus erythematosus." Master's thesis, University of Cape Town, 1992. http://hdl.handle.net/11427/26242.

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48

Aringer, M., T. Dörner, N. Leuchten, and S. R. Johnson. "Toward new criteria for systemic lupus erythematosus: a standpoint." Sage, 2016. https://tud.qucosa.de/id/qucosa%3A35520.

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While clearly different in their aims and means, classification and diagnosis both try to accurately label the disease patients are suffering from. For systemic lupus erythematosus (SLE), this is complicated by the multi-organ nature of the disease and by our incomplete understanding of its pathophysiology. Hallmarks of SLE are the presence of antinuclear antibodies (ANA), and multiple immune-mediated organ symptoms that are largely independent. In an attempt to overcome limitations of the current sets of SLE classification criteria, a new fourphase approach is being developed, which is jointl

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49

Mu, Qinghui. "The role of gut microbiota in systemic lupus erythematosus." Diss., Virginia Tech, 2018. http://hdl.handle.net/10919/82856.

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Systemic lupus erythematosus (SLE) is a multi-system autoimmune disease with no known cure. Despite years of study, the etiology of SLE is still unclear. Both genetic and environmental factors have been implicated in the disease mechanisms. Gut microbiota as an environmental factor and the immune system interact to maintain tissue homeostasis, but whether this interaction is involved in the pathogenesis of SLE is unclear. In a classical model of lupus nephritis, MRL/lpr, we found decrease of Lactobacillales but increase of Lachnospiraceae in the gut microbiota. Increasing Lac

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50

Leung, Wai-nor. "Stress and coping of patients with systemic lupus erythematosus /." Hong Kong : University of Hong Kong, 1994. http://sunzi.lib.hku.hk/hkuto/record.jsp?B13991279.

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