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Journal articles on the topic 'Systemic lupus erythematosus Immunological aspects'

Author: Grafiati

Published: 4 June 2021

Last updated: 12 February 2022

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1

Kaleda, M. I., and I. P. Nikishina. "Neuropsychiatric involvement in juvenile-onset systemic lupus erythematosus." Rheumatology Science and Practice 58, no. 4 (September 4, 2020): 437–42. http://dx.doi.org/10.47360/1995-4484-2020-437-442.

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Neuropsychiatric disorders in juvenile-onset systemic lupus erythematosus (SLE) stay in the focus of attention in recent decades due to significant influence of CNS lesions on SLE course in general, necessity to optimize therapeutic interventions and outline prognosis. This paper considers the prevalence of neurolupus in children and adolescents, specific features of the clinical picture, possible relationships with other SLE manifestations and immunological disorders, aspects of neuropsychiatric disorders pathogenesis and potential influence of growing and developing nervous system on SLE cou

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Farid, EmanM, AdlaB Hassan, AliA Abalkhail, AmgadE El-Agroudy, SameerAl-M. Arrayed, and SumayaM Al-Ghareeb. "Immunological aspects of biopsy-proven lupus nephritis in Bahraini patients with systemic lupus erythematosus." Saudi Journal of Kidney Diseases and Transplantation 24, no. 6 (2013): 1271. http://dx.doi.org/10.4103/1319-2442.121286.

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Evangelopoulos, M. E., M. Alevizaki, S. Toumanidis, D. Sotou, C. D. Evangelopoulos, D. A. Koutras, S. F. Stamatelopoulos, and M. Mavrikakis. "Mitral valve prolapse in systemic lupus erythematosus patients: clinical and immunological aspects." Lupus 12, no. 4 (April 2003): 308–11. http://dx.doi.org/10.1191/0961203303lu314oa.

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Aleksandrova, N. V., A. V. Aleksandrov, I. Yu Alekhina, and O. V. Paramonova. "CLINICAL AND IMMUNOLOGICAL ASPECTS OF CHRONIC HEADACHES IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS." Medical academic journal 19, no. 1S (December 15, 2019): 54–56. http://dx.doi.org/10.17816/maj191s154-56.

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Objective: to study the clinical and immunologica features of the manifestation of chronic pain in systemic lupus erythematosus (SLE) patients with neurological symptoms.Methods. We examined 30 healthy individuals and 38 patients with SLE. Beck’s depression questionnaire was used to assess the presence of depressive symptoms. Antibodies to adenosine deaminase (anti-ADA), β2-glycoprotein-I-dependent antibodies to phospholipids of the IgG class (anti-FL) and antibodies to double-stranded DNA (anti-dsDNA) were determined in the serum of patients with SLE. Doppler sonography of the brachiocephalic

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Kini, Sandesh, Ramesh Bhat Y, Chennakeshava Thunga, Sowmya Shashidhara, and Akshatha Anand. "Clinical and Immunological Spectrum of Systemic Lupus Erythematosus in Children." Journal of Nepal Paediatric Society 40, no. 1 (August 10, 2020): 14–20. http://dx.doi.org/10.3126/jnps.v40i1.28460.

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Introduction: Systemic Lupus Erythematosus (SLE) is an auto immune disorder affecting mainly adolescent females and young women of reproductive age. The disease is characterised by widespread inflammation of blood vessels and connective tissues due to the presence of anti-nuclear antibodies (ANA). There are limited number of studies from South India on paediatric lupus. Our objectives were to study the clinical and immunological features of childhood SLE along with treatment modalities and its outcome at the end of one year follow up. The correlation between various auto-antibodies and systemi

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Han, Bobby Kwanghoon, Katherine D. Wysham, Kevin C. Cain, Helena Tyden, Anders A. Bengtsson, and Christian Lood. "Neutrophil and lymphocyte counts are associated with different immunopathological mechanisms in systemic lupus erythematosus." Lupus Science & Medicine 7, no. 1 (May 2020): e000382. http://dx.doi.org/10.1136/lupus-2020-000382.

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ObjectiveNeutrophils contribute to the SLE pathogenesis. Neutrophil to lymphocyte ratio (NLR) is reported to correlate with disease activity in SLE. The aim of the study was to evaluate whether NLR reflects underlying immunopathogenic activity in SLE, as well as to determine the contribution of each component of NLR, neutrophil and lymphocyte count.MethodsData were obtained from a cohort of patients with SLE (n=141) recruited at Lund University, Sweden. NLR levels were compared between patients with SLE and healthy controls (n=79). The relationship between NLR and clinical and immunological ma

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Mak, Anselm. "The Impact of Vitamin D on the Immunopathophysiology, Disease Activity, and Extra-Musculoskeletal Manifestations of Systemic Lupus Erythematosus." International Journal of Molecular Sciences 19, no. 8 (August 10, 2018): 2355. http://dx.doi.org/10.3390/ijms19082355.

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Over the past two decades it has been increasingly recognized that vitamin D, aside from its crucial involvement in calcium and phosphate homeostasis and the dynamics of the musculoskeletal system, exerts its influential impact on the immune system. The mechanistic roles that vitamin D plays regarding immune activation for combating infection, as well as pathologically and mediating autoimmune conditions, have been progressively unraveled. In vitro and in vivo models have demonstrated that the action of vitamin D on various immunocytes is not unidirectional. Rather, how vitamin D affects immun

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Rodríguez, Sandra, Andrés Muñoz, Rosa-Helena Bustos, and Diego Jaimes. "Pharmacovigilance of Biopharmaceuticals in Rheumatic Diseases, Adverse Events, Evolution, and Perspective: An Overview." Biomedicines 8, no. 9 (August 23, 2020): 303. http://dx.doi.org/10.3390/biomedicines8090303.

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Since we have gained an understanding of the immunological pathophysiology of rheumatic diseases such as rheumatoid arthritis and systemic lupus erythematosus, treatment based on biological drugs has become a fundamental axis. These therapies are oriented towards the regulation of cytokines such as tumour necrosis factor-alpha (TNF-α), interleukin (IL)-6, IL-1, and the modulation of cell-mediated immunity (B cells and T cells) by anti CD20 or anti CTAL-4 agents, and can increase the risk of associated infections or adverse events (AE). In this context, the entry of biotherapeutics represented

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9

Balkrishna, Acharya, Pallavi Thakur, Shivam Singh, Swami Narsingh Chandra Dev, and Anurag Varshney. "Mechanistic Paradigms of Natural Plant Metabolites as Remedial Candidates for Systemic Lupus Erythromatosus." Cells 9, no. 4 (April 22, 2020): 1049. http://dx.doi.org/10.3390/cells9041049.

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Systemic lupus erythematosus (SLE) is a complex autoimmune disorder involving a dysregulated immune response which ultimately leads to multiple organ failure. Several immunological and cellular checkpoints are available as drug targets. However, the available chemosynthetic drugs such as non-steroidal anti-inflammatory drugs and corticosteroids provide limited therapy with extreme toxicities. Moreover, the disease heterogeneity in SLE is very difficult to manage by a single drug component. Hence, it is imperative to utilize the holistic capabilities of natural plant products as immunomodulator

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das Chagas Medeiros, M. M., M. Campos Bezerra, F. N. Holanda Ferreira Braga, M. R. Melo da Justa Feijão, A. C. Rodrigues Gois, V. C. do Rosário Rebouças, T. M. Amorim Zaranza de Carvalho, L. N. Solon Carvalho, and ÁT Mendes Ribeiro. "Clinical and immunological aspects and outcome of a Brazilian cohort of 414 patients with systemic lupus erythematosus (SLE): comparison between childhood-onset, adult-onset, and late-onset SLE." Lupus 25, no. 4 (September 23, 2015): 355–63. http://dx.doi.org/10.1177/0961203315606983.

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Todorovic-Djilas, Ljiljana, Tijana Icin, Jovanka Novakovic-Paro, and Ivana Bajkin. "Autoimmune thyroid disease and other non-endocrine autoimmune diseases." Medical review 64, no. 3-4 (2011): 183–87. http://dx.doi.org/10.2298/mpns1104183t.

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Introduction, Autoimmune diseases are chronic conditions initiated by the loss of immunological tolerance to self-antigens. They constitute heterogeneous group of disorders, in which multiple alterations in the immune system result in a spectrum of syndromes that either target specific organs or affect the body systematically. Recent epidemiological studies have shown a possible shift of one autoimmune disease to another or the fact that more than one autoimmune disease may coexist in a single patient or in the same family. Numerous autoimmune diseases have been shown to coexist frequently wit

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RAMOS-CASALS, MANUEL, SANDRA MUÑOZ, FRANCISCO MEDINA, LUIS-JAVIER JARA, JOSÉ ROSAS, JAIME CALVO-ALEN, PILAR BRITO-ZERÓN, XAVIER FORNS, and JOSE-MARIA SÁNCHEZ-TAPIAS. "Systemic Autoimmune Diseases in Patients with Hepatitis C Virus Infection: Characterization of 1020 Cases (The HISPAMEC Registry)." Journal of Rheumatology 36, no. 7 (April 15, 2009): 1442–48. http://dx.doi.org/10.3899/jrheum.080874.

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Objective.To describe the clinical and immunologic characteristics of a large series of patients with systemic autoimmune diseases (SAD) associated with chronic hepatitis C virus (HCV) infection.Methods.The HISPAMEC Registry is a multicenter international study group dedicated to collecting data on patients diagnosed with SAD with serological evidence of chronic HCV infection. The information sources are cases reported by physicians of the HISPAMEC Study Group and periodic surveillance of reported cases by a Medline search updated up to December 31, 2007.Results.One thousand twenty HCV patient

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13

Sebastiani, GD, and M. Galeazzi. "Immunogenetic studies on systemic lupus erythematosus." Lupus 18, no. 10 (August 11, 2009): 878–83. http://dx.doi.org/10.1177/0961203309106918.

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Understanding the pathogenesis of systemic lupus erythematosus (SLE) remains a considerable challenge. Multiple abnormalities of both the innate and adaptive immune system have been described and, furthermore, immunological dysfunction precedes clinical presentation by many years. There is a strong genetic basis to SLE, which means that genetic studies can play a key role in furthering our understanding of this disease. Because susceptibility variants are present from birth and are unaffected by the course of the disease, or by its treatment, genetic analysis is, perhaps uniquely, capable of i

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14

Oktem, Ozgur, Hande Yagmur, Hale Bengisu, and Bulent Urman. "Reproductive aspects of systemic lupus erythematosus." Journal of Reproductive Immunology 117 (September 2016): 57–65. http://dx.doi.org/10.1016/j.jri.2016.07.001.

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15

Relle, Manfred, Bernd Foehr, and Andreas Schwarting. "Epigenetic Aspects of Systemic Lupus Erythematosus." Rheumatology and Therapy 2, no. 1 (June 2015): 33–46. http://dx.doi.org/10.1007/s40744-015-0014-y.

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16

Qi, Yuan‐yuan, Xu‐jie Zhou, and Hong Zhang. "Autophagy and immunological aberrations in systemic lupus erythematosus." European Journal of Immunology 49, no. 4 (February 25, 2019): 523–33. http://dx.doi.org/10.1002/eji.201847679.

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17

Pan, Lu, Mei-Ping Lu, Jing-Hua Wang, Meng Xu, and Si-Rui Yang. "Immunological pathogenesis and treatment of systemic lupus erythematosus." World Journal of Pediatrics 16, no. 1 (February 22, 2019): 19–30. http://dx.doi.org/10.1007/s12519-019-00229-3.

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18

Pradhan, Vandana, M. Patwardhan, A. Rajadhyaksha, and K. Ghosh. "Clinical and immunological profile of systemic lupus erythematosus." Indian Pediatrics 50, no. 4 (April 2013): 405–7. http://dx.doi.org/10.1007/s13312-013-0115-z.

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19

Yu, Haitao, Yasuo Nagafuchi, and Keishi Fujio. "Clinical and Immunological Biomarkers for Systemic Lupus Erythematosus." Biomolecules 11, no. 7 (June 22, 2021): 928. http://dx.doi.org/10.3390/biom11070928.

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Systemic lupus erythematosus (SLE) is characterized by immune system dysfunction and is clinically heterogeneous, exhibiting renal, dermatological, neuropsychiatric, and cardiovascular symptoms. Clinical and physiological assessment is usually inadequate for diagnosing and assessing pathophysiological processes in SLE. Clinical and immunological biomarkers could play a critical role in improving diagnosis, assessment, and ultimately, control of SLE. This article reviews clinical and immunological biomarkers that could diagnose and monitor disease activity in SLE, with and without organ-specifi

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20

Dupéré, Audrey, and Yves Poulin. "Facial Lipoatrophy following Systemic Lupus Erythematosus." Journal of Cutaneous Medicine and Surgery 7, no. 3 (May 2003): 232–35. http://dx.doi.org/10.1177/120347540300700308.

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Background: Acquired partial lipodystrophy is a rare disorder. An association with systemic lupus erythematosus has been reported. In these cases, an immunologic basis is suggested by the presence of C3 nephritic factor and hypocomplementemia. Objective: The following report presents the case of a woman who developed a rapid loss of facial subcutaneous fat a few months after complete spontaneous resolution of cutaneous lesions of lupus. Conclusion: Absence of C3NeF in this case suggests that other immunological factors may be involved in the pathogenesis.

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21

Sy, Man Sun. "Systemic Lupus Erythematosus: Clinical and Experimental Aspects." Archives of Dermatology 124, no. 7 (July 1, 1988): 1136. http://dx.doi.org/10.1001/archderm.1988.01670070100036.

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22

Theofilopoulos, A. N., R. Kofler, D. Noonan, P. Singer, and F. J. Dixon. "Molecular aspects of murine systemic lupus erythematosus." Springer Seminars in Immunopathology 9, no. 2-3 (October 1986): 121–42. http://dx.doi.org/10.1007/bf02099018.

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23

Rastin, Maryam, Mahmoud Mahmoudi, Maryam Sahebari, and Nafiseh Tabasi. "Clinical & immunological characteristics in systemic lupus erythematosus patients." Indian Journal of Medical Research 146, no. 2 (2017): 224. http://dx.doi.org/10.4103/ijmr.ijmr_1356_15.

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24

Font, J., R. Cervera, M. Navarro, L. Pallares, A. Lopez-Soto, J. Vivancos, and M. Ingelmo. "Systemic lupus erythematosus in men: clinical and immunological characteristics." Annals of the Rheumatic Diseases 51, no. 9 (September 1, 1992): 1050–52. http://dx.doi.org/10.1136/ard.51.9.1050.

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25

Zharkova, Olga, Teja Celhar, Petra D. Cravens, Anne B. Satterthwaite, Anna-Marie Fairhurst, and Laurie S. Davis. "Pathways leading to an immunological disease: systemic lupus erythematosus." Rheumatology 56, suppl_1 (March 27, 2017): i55—i66. http://dx.doi.org/10.1093/rheumatology/kew427.

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26

SCALI, J. J., P. BARCENA, S. VISENTINI, J. SALOMON, and E. MORALES. "Hyperprolactinemia, Uveitis, and Systemic Lupus Erythematosus: Clinical-Immunological Correlation." Annals of the New York Academy of Sciences 876, no. 1 NEUROENDOCRIN (June 1999): 378–82. http://dx.doi.org/10.1111/j.1749-6632.1999.tb07660.x.

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27

Lila, Viktoria A., and Vadim I. Mazurov. "Profile of immunological markers in skin biopsies from patients with probable and confirmed systemic lupus erythematosus." HERALD of North-Western State Medical University named after I.I. Mechnikov 13, no. 1 (June 8, 2021): 39–48. http://dx.doi.org/10.17816/mechnikov63358.

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The purpose of this study was to determine the profile of immunoreactants deposited in intact skin biopsies from the patients with confirmed and probable systemic lupus erythematosus. The study involved 94 patients who, along with a standard clinical and laboratory examination, underwent a biopsy of clinically healthy skin in the deltoid muscle area (lupus band test). The nature and combination of immune deposits in the skin, the strength of immunofluorescence, and the location were evaluated. In the patients with significant systemic lupus erythematosus (n = 56), lupus band test was positive

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Gavva, T. N., A. A. Pecherskikh, D. E. Gogolev, L. V. Teplova, Yu S. Shklyaeva, and Ya G. Spiryakina. "Consultation with rheumatologist: debut of systemic lupus erythematosus." Medical alphabet 1, no. 11 (June 15, 2021): 55–59. http://dx.doi.org/10.33667/2078-5631-2021-11-55-59.

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Systemic lupus erythematosus (SLE) is one of the most complex rheumatological diseases, occurring with a variety of clinical forms and manifestations. The debuts and variants of the course of SLE can vary significantly, so it is called ‘chameleon disease’ or ‘the great imitator of diseases’. In 2019, a group of experts from the European Anti-Rheumatic League and the American College of Rheumatology developed the latest criteria for the diagnosis of systemic lupus erythematosus. A prerequisite for the diagnosis is a positive antinuclear factor in combination with the seven clinical criteria for

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29

Li, Philip Hei, and Chak-Sing Lau. "Efficacy and Safety of Vaccinations in Systemic Lupus Erythematosus." Journal of Clinical Rheumatology and Immunology 20, no. 01 (June 5, 2020): 35–41. http://dx.doi.org/10.1142/s2661341720300037.

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Patients with rheumatological or immunological conditions, such as systemic lupus erythematosus (SLE), are particularly vulnerable to infections either due to the underlying immunological aberrations of the disease itself or treatment-related/iatrogenic immunosuppression. Infections remain the leading cause of morbidity and mortality in SLE patients and appropriate vaccination is of paramount importance. Despite clear guidance for the most common vaccinations, the greatest barrier to appropriate vaccinations likely remains with physician awareness or willingness for recommendation. To address

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30

Mitic, Gorana. "Antiphospholipid syndrome accompanying systemic lupus erythematosus." Medical review 55, no. 3-4 (2002): 89–96. http://dx.doi.org/10.2298/mpns0204089m.

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The aim of the study was the assessment of the prevalence of antiphospholipid syndrome (APS) in patients with systemic lupus erythematosus (SLE). 72 patients with SLE had been investigated, 66 females and six males, aged 17 to 70 years, average 37,03. The presence of APA was determined using both ELISA assay for antiphospholipid antibodies ASSERACHROM APA by Diagnostica Stago and clotting tests for lupus anticoagulant: activated partial thromboplastin time (aPTT), tissue thromboplastin inhibition test (TTI) and dilute Russell viper venom time (dRVVT). Antiphospholipid antibodies have been foun

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31

Adelowo, O. O., B. H. Olaosebikan, B. A. Animashaun, and R. O. Akintayo. "Juvenile systemic lupus erythematosus in Nigeria." Lupus 26, no. 3 (October 23, 2016): 329–33. http://dx.doi.org/10.1177/0961203316672927.

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Juvenile systemic lupus erythematosus (JSLE) is a complex multisystemic autoimmune disorder of unknown cause. It accounts for about one in five cases of SLE. The tendency for SLE to run a fulminant course when it starts in childhood has made JSLE a potentially more severe disease than adult SLE. Reports of JSLE from sub-Saharan Africa are scanty in spite of the increasing reports of adult SLE. We conducted a 4-year retrospective study of JSLE cases seen at the Lagos State University Teaching Hospital between January 2010 and December 2014. Out of the 12 patients studied, eight were girls and f

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32

Levy, R. A., and J. F. de Carvalho. "Lupus and the brain: neuropsychiatric aspects in systemic lupus erythematosus." Lupus 26, no. 5 (April 2017): 451–52. http://dx.doi.org/10.1177/0961203317700487.

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33

Niewold, Timothy B., Daniel N. Clark, Rafah Salloum, and Brian D. Poole. "Interferon Alpha in Systemic Lupus Erythematosus." Journal of Biomedicine and Biotechnology 2010 (2010): 1–8. http://dx.doi.org/10.1155/2010/948364.

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The pleiotropic cytokine interferon alpha is involved in multiple aspects of lupus etiology and pathogenesis. Interferon alpha is important under normal circumstances for antiviral responses and immune activation. However, heightened levels of serum interferon alpha and expression of interferon response genes are common in lupus patients. Lupus-associated autoantibodies can drive the production of interferon alpha and heightened levels of interferon interfere with immune regulation. Several genes in the pathways leading to interferon production or signaling are associated with risk for lupus.

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34

Bhaskar, Lakkakula V. K. S., and Ganji Purnachandra Nagaraju. "Clinical and Immunogenetic Aspects of Systemic Lupus Erythematosus." Critical Reviews in Immunology 39, no. 5 (2019): 343–60. http://dx.doi.org/10.1615/critrevimmunol.2020033247.

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35

FROST, DeANNA BAKER. "Systemic Lupus Erythematosus — Basic, Applied, and Clinical Aspects." Journal of Rheumatology 43, no. 11 (November 2016): 2087. http://dx.doi.org/10.3899/jrheum.160771.

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36

Emery, Helen. "Clinical Aspects of Systemic Lupus Erythematosus in Childhood." Pediatric Clinics of North America 33, no. 5 (October 1986): 1177–90. http://dx.doi.org/10.1016/s0031-3955(16)36114-4.

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37

Rothfield, Naomi. "Clinical aspects and treatment of systemic lupus erythematosus." Current Opinion in Rheumatology 1, no. 3 (October 1989): 327–31. http://dx.doi.org/10.1097/00002281-198901030-00014.

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Justiz-Vaillant, Angel, Patrick E. Akpaka, and Peter Poonking. "Systemic Lupus Erythematosus: some Epidemiological and Clinical Aspects." American Journal of Public Health Research 3, no. 2 (February 26, 2015): 46–50. http://dx.doi.org/10.12691/ajphr-3-2-2.

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Walsh, Stephen J., Charles Algert, and Naomi F. Rothfield. "Racial aspects of comorbidity in systemic lupus erythematosus." Arthritis Care & Research 9, no. 6 (December 1996): 509–16. http://dx.doi.org/10.1002/art.1790090613.

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Andreoli, Laura, Francesca Crisafulli, and Angela Tincani. "Pregnancy and reproductive aspects of systemic lupus erythematosus." Current Opinion in Rheumatology 29, no. 5 (September 2017): 473–79. http://dx.doi.org/10.1097/bor.0000000000000415.

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41

Jones, John Verrier. "Systemic lupus erythematosus: Clinical, pathological and therapeutic aspects." Transfusion Science 13, no. 2 (April 1992): 127–28. http://dx.doi.org/10.1016/0955-3886(92)90162-a.

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John, Kevin, Krupa Varughese, Ranil Johann Boaz, and Tarun George. "Lupus cystitis: unusual cause of renal failure in systemic lupus erythematosus." BMJ Case Reports 12, no. 12 (December 2019): e233446. http://dx.doi.org/10.1136/bcr-2019-233446.

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A 42-year-old woman presented with chronic fever, abdominal pain, intermittent loose stools and dysuria for 3 months. She had recently developed acute dyspnoea with acute kidney injury. She was found to have a contracted, thick-walled bladder with bilateral hydroureteronephrosis. She underwent bilateral percutaneous nephrostomies, following which her renal function recovered. She satisfied the clinical and immunological features of the Systemic Lupus International Collaborating Clinics criteria for systemic lupus erythematosus (SLE). She was initiated on immunosuppression. Lupus cystitis with

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Samundeswari, S., V. Ramalingam, and B. Latha. "Computer-Aided Diagnosis of Systemic Lupus Erythematosus Using Immunological Profile." Medico-Legal Update 18, no. 1 (2018): 525. http://dx.doi.org/10.5958/0974-1283.2018.00112.3.

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Font, J., L. Pallares, R. Cervera, A. Lopez-Soto, M. Navarro, X. Bosch, and M. Ingelmo. "Systemic lupus erythematosus in the elderly: clinical and immunological characteristics." Annals of the Rheumatic Diseases 50, no. 10 (October 1, 1991): 702–5. http://dx.doi.org/10.1136/ard.50.10.702.

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Kadiyala, Ramya, Pushpa Gurudas Kini, Shrikiran Aroor, Sandeep Kumar, and Karen Moras. "Clinico-immunological profile and outcome of childhood systemic lupus erythematosus." Sri Lanka Journal of Child Health 48, no. 3 (September 5, 2019): 201. http://dx.doi.org/10.4038/sljch.v48i3.8753.

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46

Sakkas, Lazaros I., Maria Boulbou, Despina Kyriakou, Irene Makri, Chrysanthi Sinani, Anastasios Germenis, and Nikolaos Stathakis. "Immunological features of visceral leishmaniasis may mimic systemic lupus erythematosus." Clinical Biochemistry 41, no. 1-2 (January 2008): 65–68. http://dx.doi.org/10.1016/j.clinbiochem.2007.10.008.

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47

Gamal, Sherif M., Samar M. Fawzy, Marwa Abdo, Fatema T. Elgengehy, Shada Ghoniem, and Alkhateeb Alkemry. "Immunological profile and dyslipidemia in Egyptian Systemic Lupus Erythematosus patients." Egyptian Rheumatologist 39, no. 2 (April 2017): 89–92. http://dx.doi.org/10.1016/j.ejr.2016.05.007.

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48

Tlish, M. M., Zhanna Y. Naatyzh, N. L. Sycheva, and T. G. Kuznetsova. "Systemic lupus erythematosus in the practice of dermatology." Clinical Medicine (Russian Journal) 96, no. 3 (July 20, 2018): 277–81. http://dx.doi.org/10.18821/0023-2149-2018-96-3-277-281.

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Systemic lupus erythematosus (SLE) - an autoimmune disease of unknown etiology with multivariate manifestations, course and prognosis characterized by hyperproduction wide spectrum of organ autoantibodies and immune complexes that cause immunological damage to internal organs with the development of multiple organ failure Increased frequency of occurrence of the manifestations of autoimmune disease in dermatology practice, the complexity of creating diagnostic algorithms and untimely appointment of targeted erapii put this problem in a number of the most pressing. Skin rashes are often the lea

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Solovyov, S. K., A. A. Mesnyankina, and E. A. Aseeva. "Prospects for anti-BLyS treatment of systemic lupus erythematosus." Medical Council, no. 9 (June 12, 2019): 92–95. http://dx.doi.org/10.21518/2079-701x-2019-9-92-95.

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Review of literature on the analysis of current data on the efficacy of belimumab (BLM) in systemic lupus erythematosus (SLE). It provides data on the high efficacy of BLM in high and medium activity of SLE in patients with joints damage, skin lesions and high immunological activity. The paper describes clinical cases of a rituximab and belimumab combination therapy in SLE patients.

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Kawahara, Kyoko, Tomoyuki Mukai, Masanori Iseki, Akiko Nagasu, Hajime Nagasu, Takahiko Akagi, Shoko Tsuji, et al. "SH3BP2 Deficiency Ameliorates Murine Systemic Lupus Erythematosus." International Journal of Molecular Sciences 22, no. 8 (April 17, 2021): 4169. http://dx.doi.org/10.3390/ijms22084169.

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Abstract:

Background: The adaptor protein Src homology 3 domain-binding protein 2 (SH3BP2) is widely expressed in immune cells. It controls intracellular signaling pathways. The present study was undertaken to investigate the role of SH3BP2 in a murine systemic lupus erythematosus model. Methods: For the lupus model, we used Faslpr/lpr mice. Clinical and immunological phenotypes were compared between Faslpr/lpr and SH3BP2-deficient Faslpr/lpr mice. Splenomegaly and renal involvement were assessed. Lymphocyte subsets in the spleen were analyzed by flow cytometry. To examine the role of SH3BP2 in specific

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