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Journal articles on the topic 'Systemic Lupus Erythematosus Joint pain Skin rash'

Author: Grafiati

Published: 4 June 2025

Last updated: 1 August 2025

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1

Yogarajah, Meera, Bhradeev Sivasambu, and Eric A. Jaffe. "Bullous Systemic Lupus Erythematosus Associated with Esophagitis Dissecans Superficialis." Case Reports in Rheumatology 2015 (2015): 1–4. http://dx.doi.org/10.1155/2015/930683.

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Bullous systemic lupus erythematosus is one of the rare autoantibody mediated skin manifestation of systemic lupus erythematosus (SLE) demonstrating subepidermal blistering with neutrophilic infiltrate histologically. We present a case of a 40-year-old Hispanic female who presented with a several months’ history of multiple blistering pruritic skin lesions involving the face and trunk, a photosensitive rash over the face and neck, swelling of the right neck lymph node, and joint pain involving her elbows and wrist. Her malady was diagnosed as bullous systemic lupus erythematosus based on the i

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Patil, Dr.Bhavika, and Dr.Santosh Chavan. "Systemic Lupus Erythematosus And Ayurveda: A Perspective Case Study." International Journal of Diagnostics And Research 2, no. 2 (2025): 34–38. https://doi.org/10.5281/zenodo.14650075.

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Systemic lupus erythematosus (SLE) is a chronic multisystem autoimmune disorder characterized by inflammation and tissue damage mediated by autoantibodies and immune complexes. Predominantly affecting women of childbearing age, SLE exhibits diverse symptoms, including skin rashes, joint pain, and fatigue. From an Ayurvedic perspective, SLE closely correlates with Raktadhika Vatarakta, a condition arising from the vitiation of Vata and Rakta due to Nidanas such as improper diet and lifestyle. This case study explores the application of Ayurvedic principles in diagnosing and managing SLE.A 35-ye

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Andrean, Harry, and Raveinal Raveinal. "Lupus Eritematosus Sistemik pada Pria." Health and Medical Journal 3, no. 2 (2021): 37–42. http://dx.doi.org/10.33854/heme.v3i2.664.

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Introduction: Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by presence of nucleus autoantibody and affected multiple organ. Systemic lupus erythematosus is more common in women than men with ratio 2:1 to 15:1. Men with SLE often have a more aggressive clinical course, lead to a poorer prognosis compared with women with SLE. Case Report: A man, 29 years old came to hospital with main complain joint pain increased since 1 week ago, accompanied with red spot on face, trunk, hands, foot, and back, hair loss, swollen leg, mouth ulcer, and fatique. Malar rash and

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Mansoor, C. A., and Z. Shemin. "Kikuchi-Fujimoto disease with multiple extra-nodal features - A clinical mimic." Reumatismo 71, no. 2 (2019): 105–7. http://dx.doi.org/10.4081/reumatismo.2019.1130.

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Extranodal involvement in Kikuchi’s disease is uncommon. A 31-year-old previously healthy Indian woman was admitted with high grade fever, multiple joint pain and skin rash for 3 weeks. She had negative anti-nuclear antibodies and had features of Kikuchi’s disease on lymph node biopsy. She also had multiple extranodal manifestations including erythematous maculopapular rash, symmetric polyarthritis and hepatosplenomegaly. Kikuchi’s disease with extranodal involvement can clinically mimic diseases like hematological malignancies, connective tissue disorders and certain infections. A lymph node

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Collacott, H., A. Phillips-Beyer, N. Krucien, K. Marsh, and B. Flamion. "POS0086-PARE PATIENT PREFERENCES FOR SYSTEMIC LUPUS ERYTHEMATOSUS TREATMENTS: A DISCRETE CHOICE EXPERIMENT." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 264.2–264. http://dx.doi.org/10.1136/annrheumdis-2022-eular.830.

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BackgroundFatigue, chronic pain, and skin and joint manifestations can be debilitating for people with systemic lupus erythematosus (SLE), and managing these symptoms is vital to safeguard their quality of life (QOL). In addition, oral corticosteroids (OCS) and other immunosuppressants can expose patients with SLE to severe adverse events. However, little is known about the relative importance of SLE treatment outcomes including symptom control or the extent to which treatment risks are tolerated in exchange for this.ObjectivesTo quantify the relative importance of different SLE treatment outc

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Bharti, Anju, and Lalit Prashant Meena. "Systemic Lupus Erythematosus with Hepatosplenic Granuloma: A Rare Case." Case Reports in Immunology 2014 (2014): 1–3. http://dx.doi.org/10.1155/2014/737453.

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Background. Systemic lupus erythematosus (SLE) is an autoimmune disease which is known to present with a wide variety of clinical manifestations.Case Report. A 15-year-old male presented with complaints of moderate grade fever and generalized body swelling. There was no history of cough, weight loss, joint pain, oral ulcerations, skin rash, photosensitivity, loss of hair, pain abdomen, jaundice, or any significant illness in the past. Contrast enhanced computerized tomography of the abdomen revealed hypodense lesions in both liver and spleen (without contrast enhancement), suggestive of granul

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Kobak, L., O. Voloshyna, O. Khukhlina, et al. "Clinical Markers of the Heart and Blood Vessels Syntropic Lesions in Patients with Systemic Lupus Erythematosus, Their Diagnostic Value (Second Notice)." Lviv Clinical Bulletin, no. 3 (47) (September 30, 2024): 44–51. http://dx.doi.org/10.25040/lkv2024.03.044.

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Introduction. Systemic lupus erythematosus (SLE) due to damage to numerous organs or systems still requires comprehensive study. The aim of the study. To find out the clinical markers of the blood vessels syntropic lesions in patients with systemic lupus erythematosus, their diagnostic value. Materials and methods. 118 patients with SLE with syntropic lesions of the circulatory system were examined (107 women (90.68 %) and 11 men (9.32 %) aged 18 to 74 years (average age 42.48 ±1.12 years)). The study included the identification of clinical markers of blood vessels syntropic lesions, determina

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Solano, Francesco Giuseppe, Elisa Bellei, Aurora Cuoghi, Marialuisa Caiazzo, and Francesco Bruni. "Radical Improvement of Signs and Symptoms in Systemic Lupus Erythematosus when Treated with Hemodiafiltration with Endogenous Reinfusion Dialysis." Case Reports in Nephrology and Dialysis 5, no. 1 (2015): 106–12. http://dx.doi.org/10.1159/000381395.

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Lupus nephritis is one of the most serious complications of systemic lupus erythematosus (SLE). In the kidney, immune complexes and autoantibodies activate mesangial cells that secrete cytokines that can further amplify inflammatory processes. We present the case of a 42-year-old woman with lupus nephritis accompanied by periods of exacerbation of SLE, with necrotic-like skin lesions, psoriatic arthritis without skin psoriasis, purpura of the lower limb, petechial rash, joint pain, fever, eyelid edema with bilateral conjunctival hyperemia and itching. The patient underwent a dialytic treatment

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Salido, Evelyn O., Cherica A. Tee, Patrick W. C. Reyes, Heizel B. M. Reyes, Geraldine T. Zamora, and Michael L. Tee. "Self-Reported Symptoms in a Cohort of Rheumatoid Arthritis and Systemic Lupus Erythematosus during the COVID-19 Quarantine Period." Open Rheumatology Journal 15, no. 1 (2021): 16–23. http://dx.doi.org/10.2174/1874312902115010016.

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Background: During the first three months of the COVID-19 pandemic in the Philippines, there was a supply shortage of hydroxychloroquine and methotrexate. Limited access to medication and the life changes resulting from the COVID-19 pandemic may predispose patients with rheumatoid arthritis (RA) or systemic lupus erythematosus (SLE) to disease flares. Objective: This study aimed to investigate self-reported symptoms of disease flares among patients with rheumatoid arthritis or systemic lupus erythematosus during the COVID-19 pandemic. Methods: A total of 512 completed online surveys from patie

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Daniel, Ubokudom1* Unwam Jumbo2 Ovie Okorare3 Akanimo Antia4. "A Case of Premature ST-Segment Elevation Myocardial Infarction in a Female with Newly Diagnosed Lupus Nephritis." Annals of Case Reports and Clinical Studies 3, no. 2 (2024): 1–3. https://doi.org/10.5281/zenodo.12697173.

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Systemic lupus Erythematosus is an immune mediated illness with the highest prevalence in the United States in the African American population and ancestry. It is a multi-systemic disease affecting nearly every organ of the body manifesting as joint pain, skin changes which includes presence of malar rash, fatigue, fever, increased photosensitivity. Cardiac manifestation of SLE often involves the pericardium, myocardium, valves conduction system and coronary arteries. Coronary artery involvement is often underestimated especially if occurring in patients below the age of 45 and without signifi

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Chao, Chen, Merve Aksoy, Nidhi Varma, and Clement E. Tagoe. "Rare presentation of hypocomplementaemic urticarial vasculitis syndrome (HUVS) overlapping with systemic erythematosus lupus (SLE) and small lymphocytic lymphoma (SLL)." BMJ Case Reports 18, no. 2 (2025): e262329. https://doi.org/10.1136/bcr-2024-262329.

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Hypocomplementaemic urticarial vasculitis syndrome (HUVS) is a rare immune complex-mediated disorder marked by non-pruritic urticarial lesions, hypocomplementaemia (low C1q levels), leucocytoclastic vasculitis and systemic manifestations (joint pain, angio-oedema and uveitis). Complications include renal disease, lung disease and acute laryngeal oedema that can prove fatal. Distinguishing HUVS from systemic lupus erythematosus (SLE) is challenging due to overlapping symptoms and diagnostic criteria. Here, we present the case of a male who presented with uveitis, maculopapular (and urticarial)

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12

Boussaid, Soumaya, Marouene Ben Majdouba, Sonia Rekik, et al. "Case Report: Extensive digital gangrene as a primary manifestation of late-onset systemic lupus erythematosus." F1000Research 11 (August 10, 2022): 922. http://dx.doi.org/10.12688/f1000research.124225.1.

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Background: Digital gangrene is a rare but serious complication of systemic lupus erythematosus (SLE). It occurs usually in middle-aged patients with longer disease duration. Case: Herein we report the case of a 56-year-old man (with no history suggestive of Raynaud’s phenomenon, diabetes mellitus, smoking, trauma, infection, or chemical exposure), who presented with SLE and digital gangrene was among the first signs. He presented with a one-month history of joint pain, hair loss, photosensitivity, mouth ulcers, malar rash, dyspnea, and digital pain. Physical examination revealed painful and d

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Boussaid, Soumaya, Marouene Ben Majdouba, Sonia Rekik, et al. "Case Report: Extensive digital gangrene as a primary manifestation of late-onset systemic lupus erythematosus." F1000Research 11 (September 7, 2022): 922. http://dx.doi.org/10.12688/f1000research.124225.2.

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Background: Digital gangrene is a rare but serious complication of systemic lupus erythematosus (SLE). It occurs usually in middle-aged patients with longer disease duration. Case: Herein we report the case of a 56-year-old man (with no history suggestive of Raynaud’s phenomenon, diabetes mellitus, smoking, trauma, infection, or chemical exposure), who presented with SLE and digital gangrene was among the first signs. He presented with a one-month history of joint pain, hair loss, photosensitivity, mouth ulcers, malar rash, dyspnea, and digital pain. Physical examination revealed painful and d

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14

Indriyani, Ni Putu Dewi, Pande Ketut Kurniari, and Gede Kambayana. "Keberhasilan Terapi Rituximab pada Seorang Pasien dengan Lupus Nephritis Berat: Laporan Kasus." Intisari Sains Medis 11, no. 3 (2020): 1144–51. http://dx.doi.org/10.15562/ism.v11i3.631.

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Background: Lupus nephritis is one of complication of systemic lupus erythematosus (SLE) which manifests to the kidneys. Lupus nephritis occur in 50-60% of cases in the first ten years of the onset of SLE. Standard therapy for lupus nephritis are immunosuppressive drugs such as corticosteroids and cytostatics. In a refracter case, biologic agent has giving new hope.Case description: We report a case of seventeen years old female with chief complaints of edema in both feet, skin rash caused by sun exposure, joint pain, mouth ulcer with positive ANA test, proteinuria and high blood sugar level.

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Subba, Deepa Mala, Nandakishore Thokchom, Linda Kongbam, Erika Salam, and Deepa Yumnam. "Clinical profile of cutaneous manifestations of connective tissue diseases in North-East India." International Journal of Research in Dermatology 7, no. 5 (2021): 702. http://dx.doi.org/10.18203/issn.2455-4529.intjresdermatol20213347.

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<p class="abstract"><strong>Background:</strong> Connective tissue diseases (CTDs) are a heterogeneous group of autoimmune disorders having overlapping clinical features. Skin is often involved and it may be the earliest sign of the disease. This study highlighted the various cutaneous manifestations of common CTDs.</p><p class="abstract"><strong>Methods:</strong> A hospital-based cross-sectional study was carried out for a period of two years in 83 patients with CTDs in dermatology OPD, RIMS, Imphal. Detailed history taking, examination and relevant s

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To, Uyen, Joyce Kim, and David Chia. "Lupus Flare: An Uncommon Presentation of Disseminated Gonorrhea." Case Reports in Medicine 2014 (2014): 1–3. http://dx.doi.org/10.1155/2014/626095.

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Gonorrhea is one of the most common sexually transmitted diseases in the US with 700,000 annual cases. Although most cases of gonorrhea are localized, approximately 0.5–3% become disseminated. Here we discuss a rare case of a patient with systemic lupus erythematosus (SLE) who developed septic shock from disseminated gonorrhea infection (DGI). Our patient is a 24-year-old woman with SLE, mixed connective tissue disease with cutaneous vasculitis, and lupus nephritis who presented with several weeks of malaise and generalized body aches associated with a diffuse rash along her fingers, palms, an

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Migowa, A., J. Orwa, and R. Odhiambo. "AB0557 THE SPECTRUM OF PEDIATRIC LUPUS: DATA FROM THE KENYA PEDIATRIC RHEUMATOLOGY (KAPRI) REGISTRY." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 1405.2–1406. http://dx.doi.org/10.1136/annrheumdis-2022-eular.4676.

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BackgroundChildhood-onset systemic lupus erythematosus (cSLE) is a prototype autoimmune condition characterized by systemic organ involvement, high morbidity and mortality (1-5). A pediatric rheumatology registry is critical in defining the spectrum of pediatric lupus within the region The Kenya Pediatric Rheumatology Registry (KAPRI) registry offers a unique opportunity to pioneer and spearhead a systematic and organized format in collecting pertinent clinical information that will offer information on current clinical scenarios and offer a platform to conduct other research projects to impro

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Merola, Joseph, Victoria P. Werth, Jiyoon Choi, et al. "QUALITATIVE PATIENT INTERVIEW STUDY IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS TO ASSESS PATIENT PERCEPTION OF FATIGUE AND SKIN-RELATED SYMPTOMS." Journal of Rheumatology 52, Suppl 1 (2025): 226.3–227. https://doi.org/10.3899/jrheum.2025-0390.pv237.

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PV237 / #247Poster Topic:AS23 - SLE-Diagnosis, Manifestations, & OutcomesBackground/PurposeSystemic lupus erythematosus (SLE) is a chronic autoimmune disorder that disproportionately impacts women of childbearing age. Although the incidence varies widely based on ethnic and geographic differences, approximately 204,000 persons in the US had SLE in 2018. To understand the nature and relative importance of skin symptoms, evaluate the content validity of the Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-Fatigue) scale in SLE, and assess what constitutes meaningful change in

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Williams-Hall, Rebecca, Pamela Berry, Nicola Williamson, et al. "Generation of evidence supporting the content validity of SF-36, FACIT-F, and LupusQoL, and novel patient-reported symptom items for use in patients with systemic lupus erythematosus (SLE) and SLE with lupus nephritis (LN)." Lupus Science & Medicine 9, no. 1 (2022): e000712. http://dx.doi.org/10.1136/lupus-2022-000712.

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ObjectiveSLE and lupus nephritis (LN) have significant impacts on the health-related quality of life of patients living with the condition, which are important to capture from the patient’s perspective using patient-reported outcomes (PROs). The objectives of this study were to evaluate the content validity of PROs commonly used in SLE and LN (36-Item Short Form Health Survey (SF-36), Functional Assessment of Chronic Illness Therapy–Fatigue (FACIT-F) and Lupus Quality of Life (LupusQoL), as well as novel PRO symptom severity items measuring skin rash, joint pain, joint stiffness and swelling o

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Bagadood, Rehab M., Naeem F. Qusty, Ghadeer Yahya Almasabi, et al. "Awareness of Systemic Lupus Erythematosus among the Population of Al-Qunfudhah Area, Saudi Arabia: A Cross-sectional Study." Annals of Rheumatology and Autoimmunity 5, no. 2 (2025): 48–53. https://doi.org/10.4103/ara.ara_31_24.

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Abstract Introduction: Systemic lupus erythematosus (SLE) is a complex autoimmune disease in which the body’s immune system targets different organs or tissues, resulting in harm and malfunction. It primarily affects women aged 15–45 years. Previous studies in Saudi Arabia indicate low awareness levels about SLE, necessitating further investigation in Al-Qunfudhah. This study objected to evaluating the information about SLE and identifying misconceptions about Al-Qunfudhah people. Materials and Methods: A cross-sectional descriptive-analytical study design was used. Data were extracted through

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Guiang-Valerio, Adrienne Katrin. "GASTROINTESTINAL TUBERCULOSIS PRESENTING AS INTESTINAL OBSTRUCTION IN A 16-YEAR-OLD FILIPINO WITH PEDIATRIC SYSTEMIC LUPUS ERYTHEMATOSUS." Journal of Rheumatology 52, Suppl 1 (2025): 263.1–263. https://doi.org/10.3899/jrheum.2025-0390.pv293.

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PV293 / #569Case Report Poster Topic:AS18 - Pediatric SLEIntroductionSystemic lupus erythematosus (SLE) is a systemic disease, which can affect multiple organ systems. Gastrointestinal (GI) involvement is rare in pediatric SLE and is under-recognized. On the other hand, gastrointestinal tuberculosis (TB) is also a rare disease that can be easily missed clinically. Consequently, intestinal pseudo-obstruction in SLE and GI TB are both rare diseases and usually misdiagnosed, which may result in delay in treatment.Case Presentation With InvestigationA 16-year-old Filipino female diagnosed with SLE

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Lyu, Mi-Ae, Joseph D. Khoury, Mitsutaka Nishimoto, et al. "Single Injection of Cord Blood Regulatory T Cells Can Delay the Manifestations of Systemic Lupus Erythematosus." Blood 134, Supplement_1 (2019): 1938. http://dx.doi.org/10.1182/blood-2019-131436.

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Background: Systemic Lupus Erythematosus (SLE) is a chronic inflammatory autoimmune disorder with multi-organ involvement, including skin rash, joint pain, neurological dysfunction, pulmonary fibrosis, vasculitis, and renal failure. Previously it has been reported that SLE patients have a lower percentage of regulatory T cells (Tregs) and when compared to healthy population, Tregs derived from SLE patients show defect in their suppressor function. Our group at MD Anderson Cancer Center has already shown that a significantly lower dose of cord blood (CB) Tregs as compared to conventional T cell

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Calabuig, Pablo Martínez, Jorge Fragío Gil, Roxana González Mazarío, et al. "ANIFROLUMAB IN THE MANAGEMENT OF LUPUS HEADACHES: A CASE REPORT." Journal of Rheumatology 52, Suppl 1 (2025): 268–69. https://doi.org/10.3899/jrheum.2025-0390.pv305.

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PV305 / #413Case Report Poster Topic:AS24 - SLE-TreatmentIntroductionWe present a 52-year-old woman with a 10-year history of systemic lupus erythematosus (SLE) characterized by systemic, articular, cutaneous, and neurological involvement (lupus headache). Her condition was refractory to treatment with glucocorticoids, hydroxychloroquine, and belimumab. Despite treatment, her headaches remained resistant to nonsteroidal antiinflammatory drugs (NSAIDs), triptans, and amitriptyline. After initiating treatment with anifrolumab 300 mg monthly for 5 months, she experienced significant symptom resol

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Arshad, Ahmad, Kumar Choudhary Manoj, Nishat Huma, Kumar Praveen, and Prasad Govind. "Clinical Profile of Patients with Positive Antinuclear Antibodies in Tertiary Care Centre." International Journal of Pharmaceutical and Clinical Research 16, no. 3 (2024): 279–83. https://doi.org/10.5281/zenodo.10956583.

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<strong>Introduction: </strong>Antinuclear antibodies (ANA) are a group of antibodies that bind to components of the nucleus. ANA is the telltale sign of systemic autoimmune disease and thus can be used as a screening tool for autoimmune disease. <strong>Methodology: </strong>A prospective observational study was conducted at a tertiary care hospital from January 2019 to December 2019. This study aimed to evaluate the clinical presentation of patients with positive antinuclear antibodies. A hundred symptomatic patients with ANA-positive were selected for the study after institut

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Aseel, Abuhammad Qais Z. F. Hamarsha Iman khamayseh Osama N. Dukmak, Alkhanafsa Mohammed, and Alamlih Laith. "Systemic Lupus Erythematosus in Patient with Pyoderma Gangrenosum: A CaseBased Literature Review." Journal of International Case Reports 3, no. 1 (2024): 4–9. https://doi.org/10.5281/zenodo.10893351.

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<strong>Abstract</strong> Pyoderma Gangrenosum (PG) is a rare skin disorder that includes blisters, bullae, and ulcers, which can rapidly grow. Systemic Lupus Erythematosus (SLE) in association with PG is rarely reported, and the occurrence of PG earlier is relatively uncommon. A 33-year-old female patient known to have pyoderma gangrenosum presented with a 3-year history of polyarthralgia and morning stiffness involving both the hand and knee. She also complained of mouth ulcers, photophobia, fatigue, and sweating. Laboratory results disclosed anemia, leukopenia, and neutropenia. The autoimmu

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Wong, Guan Wee, and Michael A. Heneghan. "Association of Extrahepatic Manifestations with Autoimmune Hepatitis." Digestive Diseases 33, Suppl. 2 (2015): 25–35. http://dx.doi.org/10.1159/000440707.

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For many patients with autoimmune hepatitis (AIH), the presence of extrahepatic features is well recognised both at the time of presentation and during long-term follow-up. Concomitant ‘autoimmune disorders' have been described in 20-50% of patients with AIH, both in adults and children. Indeed, the presence of these associated phenomena has been incorporated into both the original and revised International AIH group scoring systems as an aid to codifying the diagnosis. In acute index presentations, non-specific joint pains sometimes flitting in nature have been reported in 10-60% of patients,

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Morand, E., M. Pike, J. T. Merrill, et al. "LB0004 EFFICACY AND SAFETY OF DEUCRAVACITINIB, AN ORAL, SELECTIVE, ALLOSTERIC TYK2 INHIBITOR, IN PATIENTS WITH ACTIVE SYSTEMIC LUPUS ERYTHEMATOSUS: A PHASE 2, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 209. http://dx.doi.org/10.1136/annrheumdis-2022-eular.5020a.

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BackgroundTyrosine kinase 2 (TYK2) mediates signaling of Type I interferons, IL-23, and IL-12, key cytokines involved in lupus pathogenesis. Deucravacitinib (DEUC) is an oral, selective, allosteric TYK2 inhibitor with a unique mechanism of action, distinct from Janus kinase (JAK) 1/2/3 inhibitors, and has shown efficacy in psoriasis and psoriatic arthritis.ObjectivesAssess efficacy and safety of DEUC in patients with active systemic lupus erythematosus (SLE).MethodsThis was a 48-week (wk), randomized, double-blind, placebo (PBO)-controlled, phase 2 trial (NCT03252587). Eligible patients met SL

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Rahman, Anisur. "Unusual presentations in patients with systemic lupus erythematosus: a result of disease activity or something else?" British Journal of Hospital Medicine 81, no. 4 (2020): 1–3. http://dx.doi.org/10.12968/hmed.2020.0120.

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Systemic lupus erythematosus can affect any organ or tissue, but skin manifestations, joint pain and fatigue are the most common symptoms. Two case reports in this issue describe patients with systemic lupus erythematosus who suffered severe internal organ manifestations.

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Shah, Kavina, Andrew Porter, Gagandeep Takhar, and Venkat Reddy. "Case of using mycophenolate in combination with steroids for concurrent macrophage activation syndrome and lupus flare." BMJ Case Reports 13, no. 4 (2020): e231554. http://dx.doi.org/10.1136/bcr-2019-231554.

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This report highlights the importance of tailored treatment strategies in severe systemic lupus erythematosus (SLE) flares driving the life-threatening condition, macrophage activation syndrome (MAS). We report the case of a 42-year-old woman with active systemic lupus erythematosus (SLE) who was diagnosed with MAS within 3 days of onset of lethargy, rash, joint pain and significant cytopenias. This early diagnosis meant that her condition was managed with less intensive immunosuppression with only modest doses of steroids and mycophenolate mofetil.

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Bodh, Vishal, Ritesh Kalwar, Rajesh Sharma, et al. "Lupus Enteritis: An Uncommon Manifestation of Systemic Lupus Erythematosus as an Initial Presentation." Journal of Digestive Endoscopy 08, no. 03 (2017): 134–36. http://dx.doi.org/10.4103/jde.jde_36_16.

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ABSTRACTSystemic lupus erythematosus (SLE) is an autoimmune disorder generally affects young to middle-aged women, commonly presenting as a triad of fever, rash, and joint pain but can affect multiple organs and can present in a complex fashion, varying based on the degree and severity of organ involvement. The differential for abdominal pain and diarrhea in SLE is vast and can include VIPomas, serositis, pancreatitis, intestinal vasculitis, and protein – losing enteropathy, gluten – enteropathy, intestinal pseudo-obstruction, and infection. The pathology of lupus enterits thought to be immune

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Abrahamovych, U. O., O. O. Abrahamovych, O. N. Nadashkevych, A. S. Svintsitsky, and O. V. Synenkyi. "CLARIFICATION OF DIAGNOSTIC CRITERIA FOR SYSTEMIC LUPUS ERYTHEMATOSUS." Актуальні проблеми сучасної медицини: Вісник Української медичної стоматологічної академії 20, no. 2 (2020): 4–13. http://dx.doi.org/10.31718/2077-1096.20.2.4.

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 The diagnostic criteria for systemic lupus erythematosus were first proposed in 1971 by the American College of Rheumatology. Though they have been revised several times (in 1982 and 1997), but, according to the information in the literary sources and our own clinical experience, the diagnosis may often be obvious, but the number of criteria is not sufficient and vice versa. This study aimed at improving diagnostic criteria for systemic lupus erythematosus (SLE). Materials and methods. 370 subjects (331 women, 89.46%, and 39 men, 10.54%, whose mean age was 41.24 ± 0.63 years) with confi

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Bandyopadhyay, Dhrubajyoti, Vijayan Ganesan, Debarati Bhar, et al. "Takayasu’s Arteritis with Systemic Lupus Erythematosus: A Rare Association." Case Reports in Rheumatology 2015 (2015): 1–3. http://dx.doi.org/10.1155/2015/934196.

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We report the case of a 24-year-old nondiabetic, nonhypertensive lady with history of fatigue, dyspnoea and limb claudication. She has been diagnosed with Takayasu’s arteritis. Subsequently she developed rash, alopecia, joint pain, and various other laboratory abnormalities which led to a diagnosis of SLE. Takayasu’s arteritis (TA) rarely coexists with systemic lupus erythematosus (SLE). The absence of specific SLE markers in patients with TA who subsequently develop SLE suggests that the coexistence of these conditions may be coincidental. The antiphospholipid syndrome in patients with SLE ma

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Janga, Niketha, Jagadeesan M., Kavitha M. M., and Kannan R. "Lupus enteritis as a flare up of systemic lupus erythematosus- a case report and review." International Journal of Advances in Medicine 8, no. 11 (2021): 1749. http://dx.doi.org/10.18203/2349-3933.ijam20214140.

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Systemic lupus erythematosus (SLE) generally affects young to middle-aged women, commonly presenting as a triad of fever, rash, and joint pain. Abdominal pain is a common symptom in patients with SLE. The leading causes of abdominal pain in SLE are lupus enteritis, pancreatitis, pseudo-obstruction, acalculous cholecystitis, mesenteric thrombosis, hepatic thrombosis, medications like (NSAIDS, MMF, steroids, HCQ), colon perforation. The incidence of abdominal pain in patients with SLE ranges from 8-40%, and the commonest cause is lupus enteritis. The following case describes a young woman presen

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El-Reshaid, Kamel, Shaikha Al-Bader, and Hossameldin Tawfik Sallam. "A Self-Limited Facial Rash in a Lupus Patient: The Case of Primary Facial Raynaud’s Phenomenon." Case Reports in Dermatology 13, no. 2 (2021): 366–71. http://dx.doi.org/10.1159/000517553.

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Skin is involved in 80% of systemic lupus erythematosus (SLE) and the second most affected after joint disease. Lupus-specific lesions include (a) acute ones viz. malar rash (80%), (b) subacute ones viz. photosensitive maculopapular dermatitis (50%), and (c) chronic ones viz. discoid rash. The lupus nonspecific lesions include; (a) nonscarring alopecia (86.67%), oral ulcers (56.67%), vasculitic lesions (33.34%), bullous lesions (10%), and Raynaud’s phenomenon (6.67%). In this case report, we describe a patient with SLE and antiphospholipid antibodies that had developed a transient facial form

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Rajadhyaksha, A., and S. Mehra. "Dengue fever evolving into systemic lupus erythematosus and lupus nephritis: a case report." Lupus 21, no. 9 (2012): 999–1002. http://dx.doi.org/10.1177/0961203312437807.

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Dengue viremia may be the trigger for immune complex formation in patients who are predisposed to developing autoimmune disease. We report a rare case of dengue virus infection evolving into systemic lupus erythematosus (SLE) and lupus nephritis. To the best of our knowledge this is the first case of dengue fever evolving into lupus nephritis. A 22 year old female presented with having had high grade fever, skin rash, breathlessness, retro-orbital pain, abdominal pain, arthralgias and myalgias for 10 days. She tested positive for dengue immunoglobulin M (IgM). She was given supportive treatmen

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Chaudhary, Tanuja Kumari, Nidhi Kamal Kushwaha, Rubi Shah, Anchala Patel, Shristi Timilsina, and Chandani Ojha. "Systematic Lupus Erythromatus." Journal of Birgunj Nursing Campus 1, no. 1 (2024): 83–85. https://doi.org/10.70397/jbnc.18.

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Background : Systemic lupus erythematosus (SLE) is a relapsing and unpredictable multisystem disease. The exact cause is unknown, although it appears to result from an immunoregulatory disturbance brought about by combination of genetic, hormonal, chemical, and environment factors. The major symptoms of SLE aremalar rash, discoid rash, photosensitivity, oral ulcers, arthritis, serositis, renal manifestations, neurological manifestations, haematological manifestations, immunological manifestations or a positive antinuclear antibody (ANA) result. Diagnostic criteria based on major criteria of SL

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Du, H., J. Hu, J. Su, T. Wu, R. Wu, and J. Zhu. "POS0015 BULLOUS SYSTEMIC LUPUS ERYTHEMATOSUS SUCCESSFULLY TREATED WITH MYCOPHENOLATE MOFETIL COMBINED WITH GLUCOCORTICOID: A CASE REPORT." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 222.1–222. http://dx.doi.org/10.1136/annrheumdis-2022-eular.3073.

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Background:Bullous systemic lupus erythematosus (BSLE) is a rare subtype of systemic lupus erythematosus, accounting for less than 1% of systemic lupus erythematosus (SLE) [1]. It is common in adults aged 20 to 40, with female predominace [2]. Its skin manifestations are mainly tensive blisters, especially involving oral and genital mucosa, Nissl’s sign is mostly negative, blisters break and heal to form pigmentation of varying degrees, leaving no scar. At present, the main treatment is systemic application of corticosteroids combined with immunosuppressants. Here, we report a BSLE who success

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Kusuma, Singgih, Edi Susanto, Nova Kurniati, and RM Dewi Anggraini. "A Rare Case of Antithyroid Drug-Induced Lupus Erythematosus, Graves' Disease, and Primary Infertility." Bioscientia Medicina : Journal of Biomedicine and Translational Research 9, no. 1 (2024): 6099–112. http://dx.doi.org/10.37275/bsm.v9i1.1177.

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Background: Drug-induced lupus erythematosus (DILE) is a rare autoimmune disorder that mimics idiopathic lupus erythematosus, triggered by certain medications. This case report presents a patient with DILE induced by methimazole, a commonly used antithyroid drug, along with Graves' disease and primary infertility. Case presentation: A 41-year-old woman presented with palpitations, a history of Graves' disease treated with methimazole, and primary infertility. She developed lupus-like symptoms including fever, joint pain, and skin rash. Examination revealed tachycardia, tenderness of the right

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DUARTE-GARCÍA, ALÍ, HONG FANG, CHI HUNG TO, LAURENCE S. MAGDER, and MICHELLE PETRI. "Seasonal Variation in the Activity of Systemic Lupus Erythematosus." Journal of Rheumatology 39, no. 7 (2012): 1392–98. http://dx.doi.org/10.3899/jrheum.111196.

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Objective.To determine whether there is any seasonal variation in the activity of systemic lupus erythematosus (SLE) overall and by individual organs.Methods.The study group comprised 2102 patients with SLE who were followed in a prospective longitudinal cohort study. In this cohort, 92.3% of the patients were women. The mean ± SD age of the patients was 47.9 ± 13.9 years, 56.3% were white, 37.1% were African American, and 3.1% were Asian. Global disease activity was recorded by the Safety of Estrogens in Lupus Erythematosus National Assessment – Systemic Lupus Erythematosus Disease Activity I

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Chavan, R. B., V. A. Belgaumkar, N. S. Deshmukh, and A. M. Pawar. "Toxic epidermal necrolysis like acute cutaneous lupus erythematous or drug induced toxic epidermal necrolysis: case report of a diagnostic dilemma." International Journal of Research in Dermatology 6, no. 4 (2020): 563. http://dx.doi.org/10.18203/issn.2455-4529.intjresdermatol20202667.

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<p>Systemic lupus erythematosus (SLE) is an autoimmune disorder causing microvascular inflammation with generation of antinuclear auto-antibodies. It can have varied presentations and its coexistence with other disorders makes diagnosis and management all the more challenging. We describe a young male, known case of SLE and pulmonary tuberculosis on anti-tubercular treatment presenting with sudden onset diffuse maculopapular dusky rash, oral lesions, fever, joint pain and photosensitivity. Positive Nikolsky’s sign on clinical examination, epidermal necrosis on histopathology, negative di

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Baharudin, Ruziana, Nur Suhaila Idris, Juliawati Muhammad, and Wan Noor Hasbee Wan Abdullah. "A Case Report of Male Systemic Lupus Erythematous with Antinuclear Antibodies-Negative: A Challenging Diagnosis." Korean Journal of Family Medicine 43, no. 2 (2022): 150–54. http://dx.doi.org/10.4082/kjfm.20.0211.

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Systemic lupus erythematosus (SLE) is a connective tissue disease of unknown etiology that predominantly affects women of childbearing age. We report a case of male systemic lupus erythematous with antinuclear antibodies and typical clinical presentations of multiple skin lesions, polyarticular joint pain, fatigue, anorexia, and hair loss. Full evaluations were used to establish a diagnosis of SLE. The lower prevalence of SLE among males and antinuclear antibody-negative patients poses a great challenge for diagnosis. Therefore, as primary care doctors, we need to have a high suspicion of syst

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Naga Subrahmanyam, S., D. Tagoore Vijaya Lakshmi, G. V. Naga Raju, and G. V. Pavan Kumar. "Carbamazepine Induced Drug Rash with Eosinophilia and Systemic Symptoms." Journal of Drug Delivery and Therapeutics 9, no. 1-s (2019): 367–68. http://dx.doi.org/10.22270/jddt.v9i1-s.2330.

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Stabilizes inactivated state of sodium channels, thereby making neurons less excitable may reduce activity of nucleus ventralis of the thalamus or decrease synaptic transmission or summation of temporal stimulation leading to neuronal discharge.A adult of 68 years old patient came to dermatology department with chief complaints of neuralgia over scalp to relieve the symptoms physician prescribed carbamazepine 200mg Po OD. During his 2ndweek of treatment patient developed pain,fever,sore throat followed by skin rash.Better vigilance is necessary for implementation of safe and effective treatmen

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Khan, Ulma, Sanjay Pandit, Kishore Chawla, Gaurav Dharra, Rupal Aggarwal, and Sagar Garg. "Unlocking the Enigma: Systemic Lupus Erythematosus, Pancreatitis, and Pleural Effusion." Annals of Rheumatology and Autoimmunity 4, no. 2 (2024): 50–54. http://dx.doi.org/10.4103/ara.ara_9_24.

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Abstract Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by a wide range of clinical manifestations due to its potential to affect multiple organ systems. While joint pain, skin rashes, and renal involvement are among the most common presentations, SLE can occasionally manifest in more atypical ways. Acute pancreatitis (AP) and massive pleural effusion, although rare, are potential complications of SLE. This case report highlights the unique presentation of a 33-year-old female presented with AP concurrent with a massive pleural effusion, later diagnosed with S

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Jalal, Aryan, Niaz AL-barzinji, and Sheelan Aref. "Systemic Lupus Erythematosus with Initial Manifestation as Enlargement in Cervical, Axillary and Inguinal Lymphnodes: A Case Report." Kufa Medical Journal 18, no. 2 (2022): 68–71. http://dx.doi.org/10.36330/kmj.v18i2.9769.

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Systemic lupus erythematosus (SLE) is a chronic inflammatory disease that may affect the joints, skin, kidneys, lungs, nervous system, and serous membranes and/or other organs. Lymphadenopathy is characterized by changes in the characteristics and size of the lymph nodes. It results from reticuloendothelial proliferation secondary to inflammation, infection, or malignancies. Lymphadenopathy is common in SLE. It has been reported that lymph node enlargement is observed in 25-67% of SLE patients. We reported this thirty-three-year patient with presented with lymph node enlargement in cervical, a

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Earlia, Nanda, Fitria Salim, Arie Hidayati, et al. "Dermatological Presentations in Systemic Lupus Erythematosus: A Comprehensive Case Study." Indonesian Journal of Case Reports 2, no. 2 (2024): 37–42. https://doi.org/10.60084/ijcr.v2i2.188.

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Lupus erythematosus (LE) is an inflammatory autoimmune disease with a broad clinical spectrum of multi-organ inflammation and can be life-threatening. Manifestations of LE can occur confined to the skin (cutaneous lupus erythematosus, CLE) or systemic involving several organs such as the kidneys, heart, and lungs (systemic lupus erythematosus, SLE). We report a female, 27-year-old with complaints of black spots on her back, stomach area, hands, and feet. The patient feels that the spots increase when doing activities outside the home. Patients also complain of fever, pain when swallowing, join

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Khan, Qaisar Ali, Tehmina khan, Parsa Abdi, et al. "Diagnostic Dilemma of ANA-negative Pediatric Systemic Lupus Erythematosus in a South Asian Female." Clinical Medicine Insights: Case Reports 16 (January 2023): 117954762311743. http://dx.doi.org/10.1177/11795476231174321.

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Background: Systemic lupus erythematosus (SLE) is an autoimmune disorder affecting multiple organs with different degrees of severity. SLE is typically diagnosed based on the presence of antinuclear antibodies (ANA) in the serum. However, seronegative SLE is rare and is diagnosed by clinicians when the patient’s ANA is negative but fulfills other diagnostic criteria. Case report: We report a case of a 15-year-old South Asian female with SLE who had negative antinuclear antibodies yet displayed the typical clinical presentations of photosensitive maculopapular rash, joint pain, alopecia, anemia

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Ewere Marie Ogbimi, John Raphael, Onoriedeode Thompson Ologbo, and Ebiringa Blaise Anyanwu. "Immune thrombocytopaenia as initial presentation of systemic lupus erythematosus: A case report and literature review." International Journal of Life Science Research Archive 6, no. 2 (2024): 045–51. http://dx.doi.org/10.53771/ijlsra.2024.6.2.0048.

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Immune Thrombocytopenic Purpura (ITP) may be the initial presentation of Systemic Lupus Erythematosus (SLE). We present a case report of a 22year old female who was a known patient with ITP diagnosed 6years previously at the Haematology unit when she had initially presented on account of petechial skin rashes and spontaneously bleeding gums worsened by brushing her teeth. She was then found to have a platelet count of zero with anemia and had been on intermittent steroid therapy till she developed recurrent joint pain necessitating referral to Rheumatology unit to evaluate for lupus. Further i

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Hanumaiah, Bangaru, P. Tejaswini Acharya, S. Ravitej, and Dhanya Nayak. "A Rare Case of Butterfly Target Rash." Clinical Dermatology Review 7, no. 3 (2023): 288–91. http://dx.doi.org/10.4103/cdr.cdr_13_22.

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A 25-year-old female was admitted under Internal medicine for fever and anemia. The patient had a history of fever, joint pain, photosensitivity, and rash over the malar area of the face. On examination, the patient had targetoid lesions over the malar area of the face, ulcers in the oral cavity, and chilblain lesions. The presence of a targetoid lesion in association with features suggestive of systemic lupus erythematosus (SLE) raised suspicion of Rowell syndrome (RS). Further evaluation revealed pancytopenia, proteinuria, positive antinuclear antibodies, and RA factor, confirming our suspic

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Zaki Mahmudi Dasril and Deka Viotra. "Pregnancy-Triggered Severe Lupus Nephritis with Pleural Effusion: A Case Report." Bioscientia Medicina : Journal of Biomedicine and Translational Research 9, no. 5 (2025): 7311–23. https://doi.org/10.37275/bsm.v9i5.1275.

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Background: Lupus nephritis (LN) is a severe manifestation of systemic lupus erythematosus (SLE), characterized by kidney inflammation. Pregnancy can trigger or exacerbate LN due to hormonal shifts and altered immune responses. This case highlights the challenges in diagnosing and managing pregnancy-associated LN. Case presentation: A 27-year-old woman presented with anasarca, malar rash, shortness of breath, and foamy urine during her first pregnancy. She had a history of SLE with previous symptoms limited to skin and joint involvement. Investigations revealed nephrotic-range proteinuria, hem

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Rasool, Sheraz, Amr Afifi, and Denise De Lord. "Case of atypical cutaneous Mycobacteriumchelonae infection in patient of systemic lupus erythematosus after cyclophosphamide therapy." BMJ Case Reports 12, no. 12 (2019): e231930. http://dx.doi.org/10.1136/bcr-2019-231930.

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Mycobacteriumchelonae is one of the rapidly growing non-tuberculous mycobacteria that can be isolated from water, soils and aerosols. Localised infections have been reported associated with tattoo parlours, pedicures and cosmetic procedures. But disseminated infection is usually associated with individuals who are immunocompromised, predominantly affecting limbs but sparing abdomen and back. We herein present a case where patient was on immunosuppressive therapy and developed locally severe infection around right ankle. A 69-year-old woman known to rheumatology presents in outpatients with sev

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