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Dissertations / Theses on the topic 'Systemic oxidative stress'

Author: Grafiati

Published: 18 April 2022

Last updated: 30 July 2025

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1

Gherghel, Doina. "Autonomic dysfunction and systemic oxidative stress associated with glaucomatous optic neuropathy." Thesis, Aston University, 2004. http://publications.aston.ac.uk/14543/.

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There were four principal sections to the work: 1. Investigation of ocular and systemic vascular risk factors in POAG. The principal findings of this work were: a). Glaucoma patients exhibit an anticipatory reaction to the physical stress, similar to subjects at risk for cardiovascular diseases; a blunted BP response and a reduction in ONH blood flow in response to cold provocation was also recorded. b). Silent myocardial ischaemic episodes occurred during peaks in systemic BP and HR. c). Independent of a positive history for cardiovascular diseases, patients suffering from POAG demonstrate a

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2

Pereira, Delgado Alves Jose Antonio. "Oxidative stress and vascular disease in systemic lupus erythematosus and primary antiphospholipid syndrome." Thesis, University College London (University of London), 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.412911.

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3

Kurti, Stephanie P. "The impact of lifestyle, age, and sex on systemic and airway inflammation and oxidative stress." Diss., Kansas State University, 2017. http://hdl.handle.net/2097/35294.

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Doctor of Philosophy<br>Department of Kinesiology<br>Craig A. Harms<br>The overall aim of this dissertation was to determine the impact of lifestyle (i.e. habitual and acute physical activity and diet), age, and sex on systemic and airway inflammation and oxidative stress. In study 1 (Chapter 2) we examined the impact of habitual physical activity level on the post-prandial airway inflammatory response following an acute bout of moderate intensity exercise. Results indicated that the mean exhaled nitric oxide (eNO; marker of airway inflammation) response increased for all groups at two hours p

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4

Orlandi, M. "The impact of periodontal infection and its treatment on systemic inflammation, oxidative stress and endothelium integrity." Thesis, University College London (University of London), 2016. http://discovery.ucl.ac.uk/1515839/.

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Background: Periodontitis (PD) is a chronic inflammatory disease. The low-grade systemic inflammatory and oxidative status seems to be a plausible mechanism to explain the relationship between cardiovascular disease (CVD) and PD. The aim of this PhD was to investigate the association between PD and its treatment and the human vascular homeostasis. Methods: 4 studies were conducted: 1) a systematic review and meta-analysis of cases with PD and controls to assess the differences in intima-media thickness and endothelial function between cases and controls, 2) a Randomized controlled trial invest

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5

Bourji, Khalil Ibrahim. "The Study of Oxidative Stress in Fibrotic and Non-Fibrotic Skin of Patients with Systemic Sclerosis." Doctoral thesis, Università degli studi di Padova, 2016. http://hdl.handle.net/11577/3424316.

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Background and Objectives Systemic Sclerosis (SSc) is a chronic multisystemic connective tissue disease characterized by progressive fibrosis affecting skin and internal organs. Despite serious efforts to unveil the pathogenic mechanisms of SSc, they are still unclear. High levels of Reactive Oxygen Species (ROS) in affected patients have been shown, and ROS are suggested to play a role in fibrosis pathogenesis. In this study we evaluate ROS levels in non-fibrotic and fibrotic skin of patients with SSc and we compare them with those obtained from healthy controls. Patients and Methods We e

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6

Deaton, Christopher Mark David. "Systemic and pulmonary antioxidant status oxidative stress in the horse : effects of airway inflammation, ozone and exercise." Thesis, Imperial College London, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.407491.

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7

Hardas, Sarita S. "INVESTIGATIONS OF OXIDATIVE STRESS EFFECTS AND THEIR MECHANISMS IN RAT BRAIN AFTER SYSTEMIC ADMINISTRATION OF CERIA ENGINEERED NANOMATERIALS." UKnowledge, 2012. http://uknowledge.uky.edu/chemistry_etds/7.

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Advancing applications of engineered nanomaterials (ENM) in various fields create the opportunity for intended (e.g. drug and gene delivery) or unintended (e.g. occupational and environmental) exposure to ENM. However, the knowledge of ENM-toxicity is lagging behind their application development. Understanding the ENM hazard can help us to avoid potential human health problems associated with ENM applications as well as to increase their public acceptance. Ceria (cerium [Ce] oxide) ENM have many current and potential commercial applications. Beyond the traditional use of ceria as an abrasive,

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8

Cavalcante, Ana Augusta Monteiro. "Enteral nutrition supplemented with l-glutamine and its action on the inflammatory process, the glycolytic metabolism, the immune system and the oxidative stress of patients with systemic inflammatory response syndrome." Universidade Federal do CearÃ, 2010. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=5260.

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Conselho Nacional de Desenvolvimento CientÃfico e TecnolÃgico<br>The Systemic Inflammatory Response Syndrome (SIRS) is characterized by an excessive release of inflammatory mediators as a systemic inflammatory response to a serious clinical injuries. The use of glutamine in nutraceutical doses has been studied as a strategy in tissue protection and preservative of tissue metabolic function in stressful situations, helping to improve the immune response of patients. The effects of enteral glutamine supplementation in nutraceutical doses on the inflammatory markers, of glycolytic metabolism, of

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9

Ferrigo, Davide. "A molecular approach to biological control of mycotoxigenic fungi." Doctoral thesis, Università degli studi di Padova, 2010. http://hdl.handle.net/11577/3421877.

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Food safety has become a worldwide priority in public health. Among the most important food threats, mycotoxin contamination in agricultural products represents a past, daily and incoming problem to solve. Mycotoxins are chemical compounds produced by a large variety of Fungi with very different hosts and climatic needs. In European countries, climatic conditions lead to the development of different mycotoxigenic fungi. Climate conditions of Mediterranean basin promote the development, among all, of Fusarium verticillioides in maize and Aspergillus carbonarius in grape, responsible for the pro

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10

Costa, Tatiana Xavier da. "Avalia??o dos par?metros de estresse oxidativo no l?pus eritematoso." Universidade Federal do Rio Grande do Norte, 2009. http://repositorio.ufrn.br:8080/jspui/handle/123456789/13444.

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Made available in DSpace on 2014-12-17T14:16:23Z (GMT). No. of bitstreams: 1 TatianaXC.pdf: 546242 bytes, checksum: 32d2bd23fe599a131f51f3299a41cc73 (MD5) Previous issue date: 2009-03-27<br>OBJECTIVE: The aim of this work was to analyse some oxidative stress parameters in patients of Systemic L?pus Erythematosus. PATIENTS AND METHODS: Determinations of reduced glutathione content in whole blood were carried out. The activity of superoxide dismutase, gluthatione peroxidase and catalase in erythrocytes and the concentration of reactive substances of acid thiobarbituric in plasma of patients fe

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11

Martín, Ontiyuelo Clara 1988. "Implicaciones clínicas y biológicas del déficit de hierro en pacientes con enfermedad pulmonar obstructiva crónica : Efectos tras la reposición con hierro carboximaltosa." Doctoral thesis, TDX (Tesis Doctorals en Xarxa), 2022. http://hdl.handle.net/10803/673393.

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El déficit de hierro (DH) podría jugar un papel en la enfermedad pulmonar obstructiva crónica (EPOC) dado que es fundamental en la bioenergética celular. Estudio 1: Se analizaron 18 pacientes EPOC con DH y 18 pacientes EPOC sin DH evidenciándose en el grupo con DH mayor grado de sedentarismo y menor actividad física. Estudio 2: Ensayo clínico aleatorizado con hierro carboximaltosa vs placebo. El 52,3% de los pacientes tratados con hierro mejoraron la tolerancia al ejercicio frente al 18,2% en el grupo placebo. Estudio 3: Determinación de los niveles en suero de estrés oxidativo sistémico, anti

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12

Chêne, Charlotte. "Optimisation de l'efficacité et de la tolérance du trioxyde d'arsenic (ATO) dans les maladies fibro-inflammatoires." Electronic Thesis or Diss., Université Paris Cité, 2022. http://www.theses.fr/2022UNIP5081.

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La maladie du greffon contre l'hôte (Graft-versus-Host Disease: GvHD) et la sclérodermie systémique (Ssc) sont deux pathologies pro-inflammatoires pouvant toucher différents organes tels que la peau, les poumons, l'appareil digestif. La gravité des atteintes et le manque de traitement efficace conduisent à l'engagement du pronostic vital des patients. Il a été démontré dans plusieurs études qu'un dérèglement du système immunitaire est responsable de la réponse inflammatoire exacerbée et chronique qui induit la fibrose. Le trioxyde d'arsenic (ATO) est un agent anti-cancéreux utilisé dans le tra

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13

Chimabucuro, Wilson Kohama. "Isquemia mesentérica e reposição do volume intravascular. Estudo comparativo entre duas soluções salinas com diferentes concentrações de cloreto de sódio nos eventos desencadeados pela reperfusão intestinal. Um modelo experimental em ratos." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/5/5159/tde-10062010-143136/.

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A isquemia do intestino delgado ocorre nas oclusões arteriais dos vasos mesentéricos ou associada à baixa perfusão tecidual causada por choque circulatório. Seus efeitos deletérios locais e sistêmicos frequentemente agravam a evolução clínica de muitas doenças. Este estudo experimental investiga como a reposição do volume intravascular utilizando duas soluções salinas com diferentes concentrações de sódio (solução salina fisiológica e solução 7,5% de cloreto de sódio) modifica a resposta inflamatória e o estresse oxidativo causados pela isquemia do intestino delgado. Ratos Wistar, machos, peso

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14

Rosario, Andre Loureiro. "Efeito da ressuscitação volêmica precoce na resposta inflamatória e no estresse oxidativo cardiovascular do choque séptico experimental." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/5/5160/tde-01122014-113948/.

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Os mecanismos fisiopatológicos associados aos efeitos benéficos da reanimação guiada pela saturação venosa mista de oxigênio (SvO2) durante a sepse não são claros. Nosso objetivo foi avaliar os efeitos de um algoritmo de reanimação guiado pela SvO2 incluindo fluidos, noradrenalina e dobutamina na hemodinâmica, resposta inflamatória e estresse oxidativo cardiovascular durante um modelo experimental que se assemelha clinicamente ao choque séptico. Dezoito porcos anestesiados e cateterizados (35-45 kg) foram submetidos à peritonite por inoculação fecal (0,75 g/Kg). Depois de permanecerem hipotens

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15

Schoonees, Anel. "Pycnogenol for the treatment of chronic disorders : a systematic review." Thesis, Stellenbosch : Stellenbosch University, 2011. http://hdl.handle.net/10019.1/6882.

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Thesis (MNutr)-- Stellenbosch University, 2011.<br>ENGLISH ABSTRACT: Background: Oxidative stress has been implicated in the development of a number of conditions including amongst others cancer, arthritic disorders and cardiovascular disease. Pycnogenol is a herbal dietary supplement derived from French maritime pine bark extract. Pycnogenol is standardised to contain 70 ± 5% procyanidin which is a powerful antioxidant. Pycnogenol is marketed as a supplement for preventing or treating a wide range of chronic conditions. Although several randomised controlled trials of Pycnogenol have be

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16

Maglara, Antonia. "An investigation of the role of oxidative stress and the potential protective effect glutamine supplementation in an animal model of systematic inflammation." Thesis, University of Liverpool, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.269718.

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17

Santana, Danielle Gomes. "Evidências científicas sobre o uso de plantas medicinais e avaliação do extrato de cranberry (Vaccinium macrocarpon) na pancreatite aguda experimental." Universidade Federal de Sergipe, 2017. https://ri.ufs.br/handle/riufs/3646.

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Acute pancreatitis (AP) is an inflammatory condition of the pancreas, which causes high mortality in the severe forms. Although the incidence of AP is increasing in the last years, there is no specific treatment for this condition. Preclinical evidence suggests that medicinal plants (MP) may be a viable alternative for the treatment of AP. The standardized extract of Vaccinium macrocarpon (SeVm) possesses antioxidant activity and may be useful in the treatment of this disease. The objetives of this study were to carry out a systematic review regarding the use of MP in preclinical models

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18

SERRA, GESSICA. "Harmful effect of oxysterols in the gut and at systemic level: modulatory activity of olive oil phenolics." Doctoral thesis, Università degli Studi di Cagliari, 2015. http://hdl.handle.net/11584/266371.

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A healthy and proper diet is essential to prevent the onset of various diseases, as with the diet we can also introduce harmful substances. Among others, the oxysterols are particularly relevant; they can be absorbed from the diet and are the oxidized products of cholesterol present in cholesterol-containing foodstuffs after cooking, processing and storage, such as meat, fish, dairy products and eggs. They can be also generated endogenously from either the spontaneous or enzymatic oxidation of cholesterol. Oxysterols have been shown to exert several in vitro and in vivo biochemical activitie

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19

Lin, Wei Yu, and 林威宇. "Bladder Outlet Obstruction: Biomarkers and Effect on Systemic Oxidative Stress." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/13226023959267706382.

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博士<br>長庚大學<br>臨床醫學研究所<br>99<br>As men age the prostate enlarges which compresses the urethra making it difficult to urinate. Partial bladder outlet obstruction (PBOO) occurring due to benign prostate hyperplasia (BPH) in men interferes with the ability of the bladder to empty its contents. Various animal models of PBOO, in which the urethra is partially legated, have been developed and showed changes in morphology and function similar to that in humans. Oxidative damage in bladder tissue has been detected in animals with PBOO. Our results revealed that oxidative stress could be detected in the

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20

Napolitano, Filomena. "N-FORMYL PEPTIDE RECEPTORS AND UPAR FOSTER THE OXIDATIVE STRESS IN SYSTEMIC SCLEROSIS." Tesi di dottorato, 2017. http://www.fedoa.unina.it/11452/1/Napolitano_Filomena_29.pdf.

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Systemic sclerosis (SSc) is characterized by chronic inﬂammation and ﬁbrosis. N-Formyl peptide receptors (FPRs) are chemotactic receptors involved in inﬂammation. Three FPRs have been identiﬁed: FPR1, FPR2, and FPR3. We have examined, by RT-PCR, Western blot and immunohistochemistry, FPRs expression in skin ﬁbroblasts from normal subjects and SSc patients, showing an increased expression in SSc ﬁbroblasts. Several functions of FPRs occur through the interaction with the chemotactic domain (residues 88SRSRY92) of the urokinase-type plasminogen activator receptor (uPAR). Western blot and immun

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21

Grzegorzewska, Agnieszka Paulina. "Role of oxidative stress, inflammation and fibrosis in promoting vasculopathy in systemic sclerosis related pulmonary arterial hypertension." Thesis, 2016. https://hdl.handle.net/2144/19761.

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Systemic sclerosis (SSc) is a rare connective tissue disease affecting skin and internal organs. The pathogenesis of SSc is multifactorial and includes autoimmunity, inflammation and vasculopathy. Pulmonary arterial hypertension (PAH) is among the most serious of SSc complications and is characterized by augmented vasoconstriction, neointimal remodeling and occlusion of small arteries in lung. Elevated pulmonary arterial blood pressure and volume overload in the right heart eventually lead to death from heart failure. Pre-existing elevated pro-fibrotic signaling, systemic vasculopathy and chro

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22

Lin, Jung-Chun, and 林榮鈞. "Role of the sympathetic nervous system in carbon tetrachloride-induced liver injury, hepatic oxidative stress, and systemic inflammation." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/52826408175343863806.

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博士<br>國防醫學院<br>醫學科學研究所<br>104<br>Background and Aims: Although carbon tetrachloride (CCl4) is widely used as an animal model of severe hepatic failure and the mechanisms have been arduously studied, the contribution of the sympathetic nerve system (SNS) in CCl4-induced acute liver injury remains controversial. In addition to being the primary organ involved in redox cycling, the liver is also one of the most highly innervated tissues in mammals. Although the SNS is known to modulate both liver regeneration and hepatic fibrosis, less is known regarding the role of the SNS in modulating the hepa

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23

Coelho, Nuno Filipe Ramos. "Aryl hydrocarbon receptor (ahr): a therapeutic target for systemic hypertension associated with chronic intermittent hypoxia." Doctoral thesis, 2020. http://hdl.handle.net/10362/102012.

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RESUMO: A síndrome da apneia obstrutiva do sono (SAOS) é uma perturbação respiratória relacionada com o sono, que tem vindo a ser cada vez mais prevalente. Esta condição clínica é responsável por uma multiplicidade de comorbilidades, com destaque para a hipertensão arterial sistémica (HTA). A etiopatogenia da SAOS inclui quatro principais características clínicas, nomeadamente a hipóxia crónica intermitente (HCI), a hipercapnia, o aumento da pressão intratorácica e a fragmentação do sono. Destas, a HCI assume-se como um factor chave no desenvolvimento de HTA. A SAOS é uma das causas pri

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24

Ocaña, Jesus Alejandro. "Mast cells mediate systemic immunosuppression induced by platelet-activating factor via histamine and cyclooxygenase-2 dependent mechanisms." Diss., 2016. http://hdl.handle.net/1805/10614.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>Platelet-activating Factor (PAF) stimulates various cell types by the activation of the G-protein coupled PAF-receptor (PAFR). Systemic PAFR activation induces an acute pro-inflammatory response, as well as delayed systemic immunosuppressive effects in vivo. De novo enzymatic PAF synthesis and degradation are closely regulated, but oxidative stressors, such as UVB, and cigarette smoke, can generate PAF-like species via the oxidation of membrane lipids in an unregulated process. Mast cells (MCs) and the PAFR have been shown to b

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25

Minkley, Michael. "Ironing out the pathophysiology of neurodegeneration with brain iron accumulation (NBIA) : clinical investigations and disease modelling yield novel evidence of systemic dysfunction and provide a robust and accurate disease model of NBIA." Thesis, 2018. https://dspace.library.uvic.ca//handle/1828/9321.

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Neurodegeneration with Brain Iron Accumulation (NBIA) disorders, such as Phospholipase A2G6-Associated Neurodegeneration (PLAN) and Pantothenate Kinase-Associated Neurodegeneration (PKAN), are a group of rare early-onset, genetic disorders characterized by neurodegeneration and iron accumulation inside of the basal ganglia (BG), which is accompanied by progressive motor symptoms. In order to address the limitations in available models of NBIA, a B6.C3-Pla2g6m1J/CxRwb mouse model of PLAN was characterized. This model demonstrated key hallmarks of the disease presentation in NBIA, including a se

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26

Oruebor, Jennifer Nkem. "Peripheral blood biomarkers in youth with bipolar disorder: a systematic review." Thesis, 2019. https://hdl.handle.net/2144/36613.

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Bipolar disorder (BD) is a chronic, progressive illness characterized by fluctuations in mood. It is associated with psychosocial and cognitive impairment that can affect a person’s life at home, at work or school, and in interpersonal relationships. Children and adolescents diagnosed with BD experience similar functional impairments and risk for suicidal thoughts or actions compared to adults. Additionally, they are at an increased risk for poorer prognosis during adulthood given the negative outcomes associated with early illness onset, delayed treatment, misdiagnosis, and longer illness dur

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27

Ha, Vanessa. "Effects of Dietary Pulses on Lipids and Oxidative Stress as Risk Factors of Cardiovascular Disease." Thesis, 2013. http://hdl.handle.net/1807/42859.

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The objective was to conduct a systematic review and meta-analysis of randomized feeding trials to assess the effect of dietary pulses (beans, chickpeas, lentils, peas) on established lipid targets of cardiovascular disease (CVD) and perform a secondary analysis of our randomized feeding trial to assess whether dietary pulses as a means of lowering the glycemic index offer further CVD protection by reducing oxidative stress. The meta-analysis of 26 trials (n=1013) found dietary pulse interventions significantly lowered LDL-C compared with isocaloric control interventions (mean difference=-0.17

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Marques, Joana Maria Mendonça. "Anticancer activity of lichen substances: a systematic review." Master's thesis, 2019. http://hdl.handle.net/10284/8736.

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Os líquenes são fonte de uma grande variedade de metabolitos secundários, frequentemente exclusivos desta associação, com actividades biológicas importantes como a antibiótica, anti-inflamatória, antioxidante e anticancerígena, entre outras. A evidência científica demonstra que os efeitos anticancerígenos dos líquenes se produzem através da inibição da iniciação, crescimento e invasão de vários tipos de células cancerígenas in vitro e in vivo. Foi efectuada uma revisão sistemática da actividade anticancerígena e dos mecanismos de acção de extractos e respectivas substâncias isoladas de líquene

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Shamseer, Larissa. "No stone unturned rigour versus relevance in systematic reviews /." Master's thesis, 2010. http://hdl.handle.net/10048/1017.

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Thesis (M.Sc.)--University of Alberta, 2010.<br>A thesis submitted to the Faculty of Graduate Studies and Research in partial fulfillment of the requirements for the degree of Master of Science in Clinical Epidemiology, Department of Public Health Sciences. Title from pdf file main screen (viewed on February 23, 2010). Includes bibliographical references.

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