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Journal articles on the topic 'Systemic oxidative stress'

Author: Grafiati

Published: 18 April 2022

Last updated: 30 July 2025

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1

Keaney, John F., Martin G. Larson, Ramachandran S. Vasan, et al. "Obesity and Systemic Oxidative Stress." Arteriosclerosis, Thrombosis, and Vascular Biology 23, no. 3 (2003): 434–39. http://dx.doi.org/10.1161/01.atv.0000058402.34138.11.

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Karampinis, Emmanouil, Paraskevi-Maria Nechalioti, Konstantina Eirini Georgopoulou, et al. "Systemic Oxidative Stress Parameters in Skin Cancer Patients and Patients with Benign Lesions." Stresses 3, no. 4 (2023): 785–812. http://dx.doi.org/10.3390/stresses3040054.

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Oxidative stress is caused by an imbalance between the production and subsequent accumulation of reactive oxygen species (ROS) in cells and tissues and the capacity of a biological system to eliminate these reactive substances. Systemic oxidative stress biomarkers in plasma, serum, urine, or red blood cells have been found to be elevated in many diseases, including skin cancer. UV radiation (UVR) induces damage to biomolecules that enter the bloodstream, reinforcing systemic oxidative stress. On the other hand, pre-existing systemic oxidative stress does not supply the skin with the adequate m

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3

Nsonwu, Magnus, SJ Ozims, and JK Nnodim. "Perspective of Cataract and Oxidative Stress." Series of Clinical and Biomedical Research 1, no. 1 (2024): 1–10. http://dx.doi.org/10.54178/2997-2701.v1i1a1994.

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One of the main causes of blindness is the multifactorial condition known as cataract. It is believed that oxidative stress plays a significant role in starting the cataractogenesis process. Today, it is a well-established fact that oxidative stress plays a role in both diabetes-induced cataract (diabetic) and age-related cataract (senile). The most likely cause of oxidative damage to the lens is a compromised antioxidant defense system brought on by age and diabetes-related increases in reactive oxygen species (ROS) production. The main factor contributing to cataract formation is systemic ox

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Karanikas, Evangelos, Nikolaos P. Daskalakis, and Agorastos Agorastos. "Oxidative Dysregulation in Early Life Stress and Posttraumatic Stress Disorder: A Comprehensive Review." Brain Sciences 11, no. 6 (2021): 723. http://dx.doi.org/10.3390/brainsci11060723.

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Traumatic stress may chronically affect master homeostatic systems at the crossroads of peripheral and central susceptibility pathways and lead to the biological embedment of trauma-related allostatic trajectories through neurobiological alterations even decades later. Lately, there has been an exponential knowledge growth concerning the effect of traumatic stress on oxidative components and redox-state homeostasis. This extensive review encompasses a detailed description of the oxidative cascade components along with their physiological and pathophysiological functions and a systematic presen

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5

Malenica, Maja, and Neven Meseldžić. "Oxidative stress and obesity." Arhiv za farmaciju 72, no. 2 (2022): 166–83. http://dx.doi.org/10.5937/arhfarm72-36123.

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Obesity is a disease of excessive accumulation of adipose tissue due to an increased energy intake which is disproportionate to the energy expenditure in the body. The visceral adipose tissue in the obese accumulated in that way increases the risk of developing a number of metabolic and cardiovascular diseases. Disorders such as diabetes, dyslipidemia, inflammation, endothelial dysfunction and mitochondria can contribute to the development of oxidative stress, which is especially pronounced in the abdominal type of obesity. Obesity can induce systemic oxidative stress through a variety of bioc

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6

Galassetti, Pietro R., Dan Nemet, Andria Pescatello, Christie Rose-Gottron, Jennifer Larson, and Dan M. Cooper. "Exercise, Caloric Restriction, and Systemic Oxidative Stress." Journal of Investigative Medicine 54, no. 2 (2006): 67–75. http://dx.doi.org/10.2310/6650.2005.05024.

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7

D’Aiuto, F., L. Nibali, M. Parkar, K. Patel, J. Suvan, and N. Donos. "Oxidative Stress, Systemic Inflammation, and Severe Periodontitis." Journal of Dental Research 89, no. 11 (2010): 1241–46. http://dx.doi.org/10.1177/0022034510375830.

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8

De Felice, Claudio, Lucia Ciccoli, Silvia Leoncini, et al. "Systemic oxidative stress in classic Rett syndrome." Free Radical Biology and Medicine 47, no. 4 (2009): 440–48. http://dx.doi.org/10.1016/j.freeradbiomed.2009.05.016.

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9

Mezzetti, Andrea, Maria D. Guglielmi, Sante D. Pierdomenico, et al. "Increased Systemic Oxidative Stress After Elective Endarterectomy." Arteriosclerosis, Thrombosis, and Vascular Biology 19, no. 11 (1999): 2659–65. http://dx.doi.org/10.1161/01.atv.19.11.2659.

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10

Harðardóttir, H., HAC van Helvoort, MC Vonk, FHJ van den Hoogen, PNR Dekhuijzen, and YF Heijdra. "Exercise in systemic sclerosis intensifies systemic inflammation and oxidative stress." Scandinavian Journal of Rheumatology 39, no. 1 (2010): 63–70. http://dx.doi.org/10.3109/03009740903124416.

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11

Miglioranza Scavuzzi, Bruna, and Joseph Holoshitz. "Endoplasmic Reticulum Stress, Oxidative Stress, and Rheumatic Diseases." Antioxidants 11, no. 7 (2022): 1306. http://dx.doi.org/10.3390/antiox11071306.

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Background: The endoplasmic reticulum (ER) is a multi-functional organelle responsible for cellular homeostasis, protein synthesis, folding and secretion. It has been increasingly recognized that the loss of ER homeostasis plays a central role in the development of autoimmune inflammatory disorders, such as rheumatic diseases. Purpose/Main contents: Here, we review current knowledge of the contribution of ER stress to the pathogenesis of rheumatic diseases, with a focus on rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). We also review the interplay between protein folding and

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12

Kosanovic, Tijana, Dragan Sagic, Vladimir Djukic, et al. "Time Course of Redox Biomarkers in COVID-19 Pneumonia: Relation with Inflammatory, Multiorgan Impairment Biomarkers and CT Findings." Antioxidants 10, no. 7 (2021): 1126. http://dx.doi.org/10.3390/antiox10071126.

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Although the original data on systemic oxidative stress in COVID-19 patients have recently started to emerge, we are still far from a complete profile of changes in patients’ redox homeostasis. We aimed to assess the extent of oxidative damage of proteins, lipids and DNA during the course of acute disease, as well as their association with CT pulmonary patterns. In order to obtain more insight into the origin of the systemic oxidative stress, the observed parameters were correlated with inflammatory biomarkers and biomarkers of multiorgan impairment. In this prospective study, we included 58 p

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13

Cristóbal-García, Magdalena, Fernando E. García-Arroyo, Edilia Tapia, et al. "Renal Oxidative Stress Induced by Long-Term Hyperuricemia Alters Mitochondrial Function and Maintains Systemic Hypertension." Oxidative Medicine and Cellular Longevity 2015 (2015): 1–8. http://dx.doi.org/10.1155/2015/535686.

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We addressed if oxidative stress in the renal cortex plays a role in the induction of hypertension and mitochondrial alterations in hyperuricemia. A second objective was to evaluate whether the long-term treatment with the antioxidant Tempol prevents renal oxidative stress, mitochondrial alterations, and systemic hypertension in this model. Long-term (11-12 weeks) and short-term (3 weeks) effects of oxonic acid induced hyperuricemia were studied in rats (OA, 750 mg/kg BW), OA+Allopurinol (AP, 150 mg/L drinking water), OA+Tempol (T, 15 mg/kg BW), or vehicle. Systolic blood pressure, renal blood

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14

Bînă, Anca M., Andreea I. Anechitei, Theia Lelcu, et al. "Assessment of the Systemic Oxidative Stress in Preeclampsia." Serbian Journal of Experimental and Clinical Research 23, no. 1 (2022): 45–50. http://dx.doi.org/10.2478/sjecr-2022-0010.

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Abstract Preeclampsia (PE) is a major complication of pregnancy with both mother and fetal adverse outcomes. Pregnancy is a state of increased oxidative stress that has been reported to be exacerbated when complicated with preeclampsia. However, conflicting data are available in literature regarding the systemic oxidative stress in PE pregnancies. The present pilot study was purported to assess systemic oxidative stress in preeclamptic vs healthy pregnancies. To this aim plasma derived compounds of reactive oxygen metabolites (d-ROMs) and the biological antioxidant potential (BAP) were determi

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15

Jorgensen, Anders, Katrine Breitenstein, Otto Kalliokoski, et al. "Markers of HPA-axis activity and nucleic acid damage from oxidation after electroconvulsive stimulations in rats." Acta Neuropsychiatrica 31, no. 6 (2019): 287–93. http://dx.doi.org/10.1017/neu.2019.7.

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AbstractObjective:Oxidative stress has been suggested to increase after electroconvulsive therapy (ECT), a treatment which continues to be the most effective for severe depression. Oxidative stress could potentially be mechanistically involved in both the therapeutic effects and side effects of ECT.Methods:We measured sensitive markers of systemic and central nervous system (CNS) oxidative stress on DNA and RNA (urinary 8-oxodG/8-oxoGuo, cerebrospinal fluid 8-oxoGuo, and brain oxoguanine glycosylase mRNA expression) in male rats subjected to electroconvulsive stimulations (ECS), an animal mode

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16

Sfarti, Cătălin, Alin Ciobica, Ioana-Miruna Balmus, et al. "Systemic Oxidative Stress Markers in Cirrhotic Patients with Hepatic Encephalopathy: Possible Connections with Systemic Ammoniemia." Medicina 56, no. 4 (2020): 196. http://dx.doi.org/10.3390/medicina56040196.

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Background and objectives: Oxidative stress shows evidence of dysregulation in cirrhotic patients with hepatic encephalopathy (HE), although there are still controversies regarding the connections between oxidative stress and ammonia in these patients. The aim of this study was to evaluate the oxidative stress implication in overt HE pathogenesis of cirrhotic patients. Materials and Methods: We performed a prospective case-control study, which included 40 patients divided into two groups: group A consisted of 20 cirrhotic patients with HE and increased systemic ammoniemia, and group B consiste

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17

Astiz, Susana, Antonio Gonzalez-Bulnes, Isabel Astiz, et al. "Metformin Alleviates Obesity and Systemic Oxidative Stress in Obese Young Swine." Pharmaceuticals 13, no. 7 (2020): 142. http://dx.doi.org/10.3390/ph13070142.

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The present study assessed the relationship between obesity induced by lifestyle and systemic oxidative stress and possible modulations by oral metformin treatments in young individuals, by using a translational swine model of obesity and associated cardiometabolic disorders (Iberian pig). The results indicate the existence of an age-related increase in both adiposity and systemic oxidative stress (using hydrogen peroxide as a marker), which is higher in individuals with obesogenic lifestyle and increased weight and obesity. Such effect was not found in individuals treated with metformin. The

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18

Wimalawansa, Sunil J. "Vitamin D Deficiency: Effects on Oxidative Stress, Epigenetics, Gene Regulation, and Aging." Biology 8, no. 2 (2019): 30. http://dx.doi.org/10.3390/biology8020030.

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Recent advances in vitamin D research indicate that this vitamin, a secosteroid hormone, has beneficial effects on several body systems other than the musculoskeletal system. Both 25 dihydroxy vitamin D [25(OH)2D] and its active hormonal form, 1,25-dihydroxyvitamin D [1,25(OH)2D] are essential for human physiological functions, including damping down inflammation and the excessive intracellular oxidative stresses. Vitamin D is one of the key controllers of systemic inflammation, oxidative stress and mitochondrial respiratory function, and thus, the aging process in humans. In turn, molecular a

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19

Coppolino, Giuseppe, Giuseppe Leonardi, Michele Andreucci, and Davide Bolignano. "Oxidative Stress and Kidney Function: A Brief Update." Current Pharmaceutical Design 24, no. 40 (2019): 4794–99. http://dx.doi.org/10.2174/1381612825666190112165206.

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In this review we summarized some information regarding the link between kidney and oxidative stress. Accruing evidences indicated the kidney as a fundamental organ in reactive oxygen species (ROS) production. ROS are highly reactive and cause in single cells: protein alteration, DNA damage, cellular senescence and apoptosis; while the effect of ROS in biological tissues leads to a harmful oxidation effect on all their biochemical components: lipids, proteins, carbohydrates, and nucleic acids. Oxidative stress plays a role in the pathophysiology of renal impairment and is a mediator of CKD pro

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20

Lupu, Ancuta, Gabriela Stoleriu, Alin Horatiu Nedelcu, et al. "Overview of Oxidative Stress in Systemic Lupus Erythematosus." Antioxidants 14, no. 3 (2025): 303. https://doi.org/10.3390/antiox14030303.

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Systemic lupus erythematosus (SLE) is an autoimmune disease that is frequently diagnosed in female patients, caused by multiple interacting factors. It has a complex pathogenesis which can affect almost any organ, from the kidneys to the cardiovascular, pulmonary, neurological, osteoarticular, and hematological systems. The present narrative review seeks to elucidate the role of reactive oxygen species (ROS) in the pathogenesis of SLE. The central question guiding this study is to what extent these serum protein modifications correlate with disease activity and organ damage in SLE. It is chara

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21

Liang, Qi, Limei Zhang, Qianqian Huang, et al. "Oxidative Stress Score as a Simplified Surrogate for Prognostic Stratification and Therapeutic Decision-Making in Multiple Myeloma." Pharmaceuticals 18, no. 6 (2025): 878. https://doi.org/10.3390/ph18060878.

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Background: Oxidative stress contributes to the initiation and progression of multiple myeloma and can be reflected by various biochemical indicators. However, whether systemic oxidative stress level can serve as a simple and effective alternative for prognostic risk stratification in newly diagnosed multiple myeloma (NDMM) patients remains to be explored and validated in large clinical cohorts. Methods: A retrospective analysis was conducted on 1107 NDMM patients, 774 patients were randomly assigned to the training cohort and 333 to the validation cohort. They were divided into two groups bas

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22

Inchingolo, Francesco, Massimo Marrelli, Susanna Annibali, et al. "Influence of Endodontic Treatment on Systemic Oxidative Stress." International Journal of Medical Sciences 11, no. 1 (2014): 1–6. http://dx.doi.org/10.7150/ijms.6663.

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23

Kılıç, Raşit, Tongabay Cumurcu, Enver Sancaktar, Osman Evliyaoğlu, and Hafize Sezer. "Systemic Prolidase Activity and Oxidative Stress in Keratoconus." Current Eye Research 41, no. 1 (2015): 28–33. http://dx.doi.org/10.3109/02713683.2015.1004717.

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24

Troost, R., E. Schwedhelm, S. Rojczyk, D. Tsikas, and J. C. Frölich. "Nebivolol decreases systemic oxidative stress in healthy volunteers." British Journal of Clinical Pharmacology 50, no. 4 (2000): 377–79. http://dx.doi.org/10.1046/j.1365-2125.2000.00258.x.

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25

Firuzi, Omidreza, Leoš Fuksa, Chiara Spadaro, et al. "Oxidative stress parameters in different systemic rheumatic diseases." Journal of Pharmacy and Pharmacology 58, no. 7 (2006): 951–57. http://dx.doi.org/10.1211/jpp.58.7.0010.

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26

Toprak, I., V. Kucukatay, C. Yildirim, E. Kilic-Toprak, and O. Kilic-Erkek. "Increased systemic oxidative stress in patients with keratoconus." Eye 28, no. 3 (2013): 285–89. http://dx.doi.org/10.1038/eye.2013.262.

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27

Araujo, Jesus A. "Air particulate pollutants, systemic oxidative stress and atherosclerosis." Clínica e Investigación en Arteriosclerosis 22 (December 2010): 28–32. http://dx.doi.org/10.1016/s0214-9168(10)70033-4.

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28

Škrgat, Sabina, Robert Marčun, Izidor Kern, et al. "Systemic and airway oxidative stress in competitive swimmers." Respiratory Medicine 137 (April 2018): 129–33. http://dx.doi.org/10.1016/j.rmed.2018.03.005.

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29

Rahman, I., D. Morrison, K. Donaldson, and W. MacNee. "Systemic oxidative stress in asthma, COPD, and smokers." American Journal of Respiratory and Critical Care Medicine 154, no. 4 (1996): 1055–60. http://dx.doi.org/10.1164/ajrccm.154.4.8887607.

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30

Degl'Innocenti, Donatella, Matteo Becatti, Marta Peruzzi, et al. "Systemic oxidative stress in congenital central hypoventilation syndrome." European Respiratory Journal 52, no. 5 (2018): 1801497. http://dx.doi.org/10.1183/13993003.01497-2018.

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31

Koutsokera, Angela, Andriana I. Papaioannou, Foteini Malli, et al. "Systemic oxidative stress in patients with pulmonary sarcoidosis." Pulmonary Pharmacology & Therapeutics 22, no. 6 (2009): 603–7. http://dx.doi.org/10.1016/j.pupt.2009.09.002.

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32

de Ornellas Strapazzon, Juliana, Eduardo Benedetti Parisotto, Ana Maria Moratelli, et al. "Systemic oxidative stress in victims of Bothrops snakebites." Journal of Applied Biomedicine 13, no. 2 (2015): 161–67. http://dx.doi.org/10.1016/j.jab.2014.11.002.

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33

Segal, BM, W. Thomas, X. Zhu, et al. "Oxidative stress and fatigue in systemic lupus erythematosus." Lupus 21, no. 9 (2012): 984–92. http://dx.doi.org/10.1177/0961203312444772.

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Objective: The objective of this study is to investigate the relationship of oxidative stress to fatigue in systemic lupus erythematosus (SLE). Methods: Patients with a confirmed diagnosis of SLE by ACR criteria and healthy controls completed validated questionnaires to assess depression and fatigue. Fatigue was measured with the Fatigue Severity Scale (FSS) and the Profile of Fatigue (Prof-F). Visual analogue scales (VAS) were also used to assess fatigue and pain. Depression was measured with the Center for Epidemiologic Studies Depression Scale (CES-D). Plasma F2-isoprostane was measured wit

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Samal, I. R., M. Maneesh, and A. Chakrabarti. "Evidence for systemic oxidative stress in tobacco chewers." Scandinavian Journal of Clinical and Laboratory Investigation 66, no. 6 (2006): 517–22. http://dx.doi.org/10.1080/00365510600844747.

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35

Vlasceanu, Ana-Maria, Daniela Gradinaru, Miriana Stan, Viorela G. Nitescu, and Daniela Luiza Baconi. "Relationships between Serum Biomarkers of Oxidative Stress and Tobacco Smoke Exposure in Patients with Mental Disorders." Antioxidants 12, no. 6 (2023): 1299. http://dx.doi.org/10.3390/antiox12061299.

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The role of cigarette smoking as an aggravating factor of systemic oxidative stress in patients with mental disorders has not been extensively investigated, although significantly higher rates of smoking are recorded in these subjects in comparison with the general population. In the present study, we tested the hypothesis that smoking might be an exacerbator of systemic oxidative stress, being directly correlated with the degree of exposure to tobacco smoke. We analyzed, in 76 adult subjects from a public health care unit, the relationships between serum cotinine levels as a marker of tobacco

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Badran, Mohammad, Bisher Abuyassin, Saeid Golbidi, Najib Ayas, and Ismail Laher. "Alpha Lipoic Acid Improves Endothelial Function and Oxidative Stress in Mice Exposed to Chronic Intermittent Hypoxia." Oxidative Medicine and Cellular Longevity 2019 (April 9, 2019): 1–13. http://dx.doi.org/10.1155/2019/4093018.

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Objective. Obstructive sleep apnea (OSA) is characterized by recurrent airway collapse that causes chronic intermittent hypoxia (CIH). OSA is associated with systemic inflammation and oxidative stress resulting in endothelial dysfunction and cardiovascular disease (CVD). Alpha lipoic acid (ALA) is a potent antioxidant with anti-inflammatory properties. We hypothesized that dietary ALA can improve endothelial function of mice exposed to CIH. Methods. Mice were exposed to either CIH or intermittent air (IA) and treated with dietary ALA (0.2% w/w) or a regular chow diet for 8 weeks. Endothelial f

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Dąbkowski, Kamil, Ewelina Kreft, Kornelia Sałaga-Zaleska, et al. "Human In Vitro Oxidized Low-Density Lipoprotein (oxLDL) Increases Urinary Albumin Excretion in Rats." International Journal of Molecular Sciences 25, no. 10 (2024): 5498. http://dx.doi.org/10.3390/ijms25105498.

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Hypercholesterolemia-associated oxidative stress increases the formation of oxidized low-density lipoprotein (oxLDL), which can affect endothelial cell function and potentially contribute to renal dysfunction, as reflected by changes in urinary protein excretion. This study aimed to investigate the impact of exogenous oxLDL on urinary excretion of albumin and nephrin. LDL was isolated from a patient with familial hypercholesterolemia (FH) undergoing lipoprotein apheresis (LA) and was oxidized in vitro with Cu (II) ions. Biochemical markers of LDL oxidation, such as TBARS, conjugated dienes, an

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38

Lozovoy, MAB, ANC Simão, MSN Hohmann, et al. "Inflammatory biomarkers and oxidative stress measurements in patients with systemic lupus erythematosus with or without metabolic syndrome." Lupus 20, no. 13 (2011): 1356–64. http://dx.doi.org/10.1177/0961203311411348.

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The aims of the present study were to report the frequency of metabolic syndrome in systemic lupus erythematosus (SLE); to verify differences in inflammatory biomarkers and oxidative stress in SLE patients with or without metabolic syndrome; and to assess which metabolic syndrome components are associated with oxidative stress and disease activity. The study included 58 SLE patients and 105 controls. SLE patients were divided in two groups, with and without metabolic syndrome. 41.4% patients met the criteria for metabolic syndrome compared with 10.5% controls. Patients with SLE and metabolic s

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Boșca, Bianca Adina, Viorel Miclăuș, Aranka Ilea, et al. "Role of nitro-oxidative stress in the pathogenesis of experimental rat periodontitis." Medicine and Pharmacy Reports 89, no. 1 (2016): 150–59. http://dx.doi.org/10.15386/cjmed-529.

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Background and aims. Periodontitis is a common chronic adult condition that implicates oxidative damage to gingival tissue, periodontal ligament and alveolar bone. This study aimed at assessing the association between the nitro-oxidative stress and the periodontal tissues destructions in experimental rat periodontitis.Methods. Periodontitis was induced in 15 male albino rats by repetitive lesions to the gingiva adjacent to the inferior incisors, performed daily, for 16 days. On D1, D3, D6, D8, and D16 the onset and evolution of periodontitis were monitored by clinical and histopathological exa

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Yang, Ji, Xue Yang, Hejian Zou, and Ming Li. "Oxidative Stress and Treg and Th17 Dysfunction in Systemic Lupus Erythematosus." Oxidative Medicine and Cellular Longevity 2016 (2016): 1–9. http://dx.doi.org/10.1155/2016/2526174.

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Systemic lupus erythematosus (SLE) is an autoimmune disease that involves multiple organ systems. The pathogenic mechanisms that cause SLE remain unclear; however, it is well recognized that the immune balance is disturbed and that this imbalance contributes to the autoimmune symptoms of SLE. Oxidative stress represents an imbalance between the production and manifestation of reactive oxygen species and the ability of the biological system to readily detoxify the reactive intermediates or to repair the resulting damage. In humans, oxidative stress is involved in many diseases, including athero

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McNulty, Patrick H., Mark A. Tulli, Bryan J. Robertson, et al. "Effect of simulated postprandial hyperglycemia on coronary blood flow in cardiac transplant recipients." American Journal of Physiology-Heart and Circulatory Physiology 293, no. 1 (2007): H103—H108. http://dx.doi.org/10.1152/ajpheart.00779.2006.

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Patients with diabetes mellitus exhibit postprandial hyperglycemia, systemic oxidative stress, impaired endothelium-dependent, nitric oxide (NO)-mediated coronary artery dilatation, and an increased incidence of coronary events. Whether hyperglycemia causally mediates these associations is unknown. To test the hypothesis that postprandial hyperglycemia acutely impairs coronary endothelial function in humans, we compared the ability of the endothelium-dependent vasodilator acetylcholine to increase conduit coronary diameter (the macrovascular response) and coronary blood flow velocity (the micr

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Ramani, Sheetal, Ayush Pathak, Vikram Dalal, Anamika Paul, and Sagarika Biswas. "Oxidative Stress in Autoimmune Diseases: An Under Dealt Malice." Current Protein & Peptide Science 21, no. 6 (2020): 611–21. http://dx.doi.org/10.2174/1389203721666200214111816.

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Oxidative stress is the off-balance of antioxidants and free radicals. All kinds of diseases and disorders give rise to oxidative damage including autoimmune diseases. An autoimmune disorder is a pathological condition characterized by the breakdown of self-tolerance of the immune system in the body. Immunological processes against tissues and organs lead to enhanced oxidative stress and, in turn, misbalance of oxidative stress aggravates the pathobiology of the disease. Highly reactive nature of free radicals, for example hydroxyl and superoxide ions, alters DNA, protein, and lipids in the bo

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Vikram, Kesar, and Goel Kesar Alpana. "Thyroid Hormones and Oxidative Stress." International Journal of Pharmaceutical and Clinical Research 15, no. 12 (2023): 1717–20. https://doi.org/10.5281/zenodo.11206804.

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Thyroid hormones have a pro-oxidant effect and cause increased lipid peroxidation. Lipid peroxidation is an extremely damaging process implicated in many diseases and could be a causative factor, responsible for the varied systemic manifestations of hyperthyroidism, like myopathy and myocardial insufficiency. The activities of, anti-oxidant scavenging enzymes erythrocyte superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPX), which prevent lipid peroxidation are also significantly affected, by hyperthyroidism and hypothyroidism. Further it has been observed in various stu

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Fibbi, Benedetta, Giada Marroncini, Cecilia Anceschi, Laura Naldi, and Alessandro Peri. "Hyponatremia and Oxidative Stress." Antioxidants 10, no. 11 (2021): 1768. http://dx.doi.org/10.3390/antiox10111768.

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Hyponatremia, i.e., the presence of a serum sodium concentration ([Na+]) < 136 mEq/L, is the most frequent electrolyte imbalance in the elderly and in hospitalized patients. Symptoms of acute hyponatremia, whose main target is the central nervous system, are explained by the “osmotic theory” and the neuronal swelling secondary to decreased extracellular osmolality, which determines cerebral oedema. Following the description of neurological and systemic manifestations even in mild and chronic hyponatremia, in the last decade reduced extracellular [Na+] was associated with detrimental effects

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Negi, Smita I., Euy-Myoung Jeong, Irfan Shukrullah, et al. "Renin-Angiotensin Activation and Oxidative Stress in Early Heart Failure with Preserved Ejection Fraction." BioMed Research International 2015 (2015): 1–7. http://dx.doi.org/10.1155/2015/825027.

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Animal models have suggested a role of renin-angiotensin system (RAS) activation and subsequent cardiac oxidation in heart failure with preserved ejection fraction (HFpEF). Nevertheless, RAS blockade has failed to show efficacy in treatment of HFpEF. We evaluated the role of RAS activation and subsequent systemic oxidation in HFpEF. Oxidative stress markers were compared in 50 subjects with and without early HFpEF. Derivatives of reactive oxidative metabolites (DROMs), F2-isoprostanes (IsoPs), and ratios of oxidized to reduced glutathione (EhGSH) and cysteine (EhCyS) were measured. Angiotensin

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Nono Nankam, Pamela A., Télesphore B. Nguelefack, Julia H. Goedecke, and Matthias Blüher. "Contribution of Adipose Tissue Oxidative Stress to Obesity-Associated Diabetes Risk and Ethnic Differences: Focus on Women of African Ancestry." Antioxidants 10, no. 4 (2021): 622. http://dx.doi.org/10.3390/antiox10040622.

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Adipose tissue (AT) storage capacity is central in the maintenance of whole-body homeostasis, especially in obesity states. However, sustained nutrients overflow may dysregulate this function resulting in adipocytes hypertrophy, AT hypoxia, inflammation and oxidative stress. Systemic inflammation may also contribute to the disruption of AT redox equilibrium. AT and systemic oxidative stress have been involved in the development of obesity-associated insulin resistance (IR) and type 2 diabetes (T2D) through several mechanisms. Interestingly, fat accumulation, body fat distribution and the degre

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Cocco, Carola, Mariacristina Siotto, Alessandro Guerrini, et al. "Systemic Oxidative Stress in Subacute Stroke Patients Undergoing Rehabilitation Treatment." Antioxidants 13, no. 3 (2024): 354. http://dx.doi.org/10.3390/antiox13030354.

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The imbalance in oxidative stress in acute stroke has been extensively studied; on the contrary, its investigation in the subacute phase is limited. The aim of this study was to analyse the variation in the systemic oxidative status in subacute post-stroke patients before (T0) and after a six-week rehabilitation treatment (T1) and to investigate the relationship between systemic oxidative status and rehabilitation outcomes. We enrolled 109 subjects in two different centres, and we analysed their serum hydroperoxide levels (d-ROMs), biological antioxidant power (BAP), thiol antioxidant componen

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Dooley, Audrey, K. Richard Bruckdorfer, and David J. Abraham. "Modulation of Fibrosis in Systemic Sclerosis by Nitric Oxide and Antioxidants." Cardiology Research and Practice 2012 (2012): 1–9. http://dx.doi.org/10.1155/2012/521958.

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Systemic sclerosis (scleroderma: SSc) is a multisystem, connective tissue disease of unknown aetiology characterized by vascular dysfunction, autoimmunity, and enhanced fibroblast activity resulting in fibrosis of the skin, heart, and lungs, and ultimately internal organ failure, and death. One of the most important and early modulators of disease activity is thought to be oxidative stress. Evidence suggests that the free radical nitric oxide (NO), a key mediator of oxidative stress, can profoundly influence the early microvasculopathy, and possibly the ensuing fibrogenic response. Animal mode

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Aku, Amulya Murthy, Ashok Patil, and Mukund Sabnis. "STHAULYA, AMA, AND MEDA DHATU, THE DYSFUNCTIONAL NUTRITIONAL METABOLISM WITH SPECIAL REFERENCE TO OXIDATIVE STRESS: A NARRATIVE REVIEW." International Journal of Research in Ayurveda and Pharmacy 13, no. 04 (2022): 95–98. http://dx.doi.org/10.7897/2277-4343.130496.

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Obesity and its accompanying consequences are increasingly linked to oxidative stress, as evidenced by a growing body of research. Several biochemical pathways, including superoxide production from NADPH oxidases and glyceraldehyde auto-oxidation, can cause systemic oxidative stress in obese individuals. Hyperleptinemia, inadequate antioxidant defence, chronic inflammation, and postprandial reactive oxygen species production contribute to oxidative stress. This Oxidative stress is related to or co-related to “Ama”. Ama is generated by improper or insufficient digestion of food particles due to

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Souliotis, Vassilis L., Nikolaos I. Vlachogiannis, Maria Pappa, Alexandra Argyriou, Panagiotis A. Ntouros, and Petros P. Sfikakis. "DNA Damage Response and Oxidative Stress in Systemic Autoimmunity." International Journal of Molecular Sciences 21, no. 1 (2019): 55. http://dx.doi.org/10.3390/ijms21010055.

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The DNA damage response and repair (DDR/R) network, a sum of hierarchically structured signaling pathways that recognize and repair DNA damage, and the immune response to endogenous and/or exogenous threats, act synergistically to enhance cellular defense. On the other hand, a deregulated interplay between these systems underlines inflammatory diseases including malignancies and chronic systemic autoimmune diseases, such as systemic lupus erythematosus, systemic sclerosis, and rheumatoid arthritis. Patients with these diseases are characterized by aberrant immune response to self-antigens with

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