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Relevant bibliographies by topics / Systems biophysics

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Academic literature on the topic 'Systems biophysics'

Author: Grafiati

Published: 7 June 2025

Last updated: 26 June 2025

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Journal articles on the topic "Systems biophysics"

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McCulloch, Andrew D. "Systems Biophysics: Multiscale Biophysical Modeling of Organ Systems." Biophysical Journal 110, no. 5 (2016): 1023–27. http://dx.doi.org/10.1016/j.bpj.2016.02.007.

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Riznichenko, G. Yu, A. A. Anashkina, and A. B. Rubin. "VII congress of biophysicists of Russia." Биофизика 68, no. 4 (2023): 831–32. http://dx.doi.org/10.31857/s0006302923040233.

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The problems and results of research in biophysics, which were devoted to the VII Congress of Biophysicists of Russia (Krasnodar, April 17-23, 2023, http://rusbiophysics.ru/db/conf.pl), are discussed. The results of fundamental and applied research in the field of molecular biophysics, cell biophysics, biophysics of complex multicomponent systems were presented at plenary, sectional and poster sessions. The structure and dynamics of biopolymers, the fundamental mechanisms underlying the impact of physicochemical factors on biological systems, membrane and transport processes were actively discussed. Much attention was paid to new experimental methods of biophysical research, methods of bioinformatics, computer and mathematical modeling as essential research tools at all levels of organization of living systems. Along with the fundamental problems of studying the biophysical mechanisms of regulation of processes at the molecular, subcellular and cellular levels, much attention was paid to applied research in the field of biotechnology and environmental monitoring. Works in the field of medical biophysics were especially widely represented. During the Congress, the National Council for Biophysics was formed.

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Toshpolatov, Ch. "Biophysics of short systems." ACADEMICIA: An International Multidisciplinary Research Journal 12, no. 2 (2022): 261–63. http://dx.doi.org/10.5958/2249-7137.2022.00117.3.

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Noble, Denis. "Biophysics and systems biology." Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences 368, no. 1914 (2010): 1125–39. http://dx.doi.org/10.1098/rsta.2009.0245.

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Biophysics at the systems level, as distinct from molecular biophysics, acquired its most famous paradigm in the work of Hodgkin and Huxley, who integrated their equations for the nerve impulse in 1952. Their approach has since been extended to other organs of the body, notably including the heart. The modern field of computational biology has expanded rapidly during the first decade of the twenty-first century and, through its contribution to what is now called systems biology, it is set to revise many of the fundamental principles of biology, including the relations between genotypes and phenotypes. Evolutionary theory, in particular, will require re-assessment. To succeed in this, computational and systems biology will need to develop the theoretical framework required to deal with multilevel interactions. While computational power is necessary, and is forthcoming, it is not sufficient. We will also require mathematical insight, perhaps of a nature we have not yet identified. This article is therefore also a challenge to mathematicians to develop such insights.

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Vilar, Jose M. G., and Leonor Saiz. "Systems Biophysics of Gene Expression." Biophysical Journal 104, no. 12 (2013): 2574–85. http://dx.doi.org/10.1016/j.bpj.2013.04.032.

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Eryomin, A. L. "Biophysics of Evolution of Intellectual Systems." Biophysics 67, no. 2 (2022): 320–26. http://dx.doi.org/10.1134/s0006350922020051.

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Chow, James C. L. "Biophysical insights into nanomaterial-induced DNA damage: mechanisms, challenges, and future directions." AIMS Biophysics 11, no. 3 (2024): 340–69. http://dx.doi.org/10.3934/biophy.2024019.

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<p>Nanomaterials have garnered significant attention due to their unique properties and wide-ranging applications in medicine and biophysics. However, their interactions with biological systems, particularly DNA, raise critical concerns about genotoxicity and potential long-term health risks. This review delves into the biophysical mechanisms underlying nanomaterial-induced DNA damage, highlighting recent insights, current challenges, and future research directions. We explore how the physicochemical properties of nanomaterials influence their interaction with DNA, the pathways through which they induce damage, and the biophysical methods employed to study these processes.</p>

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Kutti Kandy, Sreeja, Paul A. Janmey, and Ravi Radhakrishnan. "Membrane signalosome: Where biophysics meets systems biology." Current Opinion in Systems Biology 25 (March 2021): 34–41. http://dx.doi.org/10.1016/j.coisb.2021.02.001.

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Djordjevic, Marko, Andjela Rodic, and Stefan Graovac. "From biophysics to ‘omics and systems biology." European Biophysics Journal 48, no. 5 (2019): 413–24. http://dx.doi.org/10.1007/s00249-019-01366-3.

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Birchenough, Holly L., Hilda D. Ruiz Nivia, and Thomas A. Jowitt. "Interaction standards for biophysics: anti-lysozyme nanobodies." European Biophysics Journal 50, no. 3-4 (2021): 333–43. http://dx.doi.org/10.1007/s00249-021-01524-6.

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AbstractThere is a significant demand in the molecular biophysics community for robust standard samples. They are required by researchers, instrument developers and pharmaceutical companies for instrumental quality control, methodological development and in the design and validation of devices, diagnostics and instrumentation. To-date there has been no clear consensus on the need and type of standards that should be available and different research groups and instrument manufacturers use different standard systems which significantly hinders comparative analysis. One of the major objectives of the Association of Resources for Biophysical Research in Europe (ARBRE) is to establish a common set of standard samples that can be used throughout the biophysics community and instrument developers. A survey was circulated among ARBRE members to ascertain the requirements of laboratories when using standard systems and the results are documented in this article. In summary, the major requirements are protein samples which are cheap, relatively small, stable and have different binding strengths. We have developed a panel of sdAb’s or ‘nanobodies’ against hen-egg white lysozyme with different binding strengths and suitable stability characteristics. Here we show the results of the survey, the selection procedure, validation and final selection of a panel of nanobody interaction standards.

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Dissertations / Theses on the topic "Systems biophysics"

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Schwab, David Jason. "Topics in biophysics and disordered quantum systems." Diss., Restricted to subscribing institutions, 2009. http://proquest.umi.com/pqdweb?did=1971489301&sid=1&Fmt=2&clientId=1564&RQT=309&VName=PQD.

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Iram, Shamreen. "Characterization and Control of Cellular Systems." Case Western Reserve University School of Graduate Studies / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=case1607450707990284.

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Huff, Alison. "A Hydrostatic Pressure Perfusion System for Biological Systems." Miami University / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=miami1343970397.

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Lee, Choon-Hwan. "Multilinear analysis of fluorescence spectra of photosynthetic systems /." The Ohio State University, 1988. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487594970651308.

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Barrass, David Bryan. "Mathematical modelling of pulsatility in neuroendocrine systems." Thesis, Sheffield Hallam University, 1993. http://shura.shu.ac.uk/19321/.

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The work described in this thesis concerns the mathematical description of the characteristic oscillatory electrical behaviour of certain neurosecretory cells found in the hypothalamus of the mammalian brain. This study concentrates on those cells which secrete the hormone oxytocin. A model first described by Hodgkin and Huxley is used as a starting point for the derivation of a description comprising a system of coupled non-linear partial differential equations. The equations have been based wherever possible on experimental data relevant to the system being studied. Where this has not been possible, alternative models based on data from other, related systems have been used. The thesis starts with a discussion of the physiology of the system under study and presents some background material. The second chapter discusses the process of mathematical modelling of neurones and presents some of the relevant work in the area. The model due to Hodgkin and Huxley is significant and is discussed in detail. The research methodology is then outlined. Experimental procedures for recording the electrical behaviour of nerve cells and methods of recording selected ionic currents are the subject of chapter three. Chapter four presents a discussion of oscillatory behaviour in nerve cells at a general level and outlines the features necessary for a nerve cell to exhibit oscillation. The next three chapters discuss the characteristics of the different ionic currents involved and describe the author's derivation of models of these currents. Chapter Five presents the author's model of the sodium current, Chapter Six, the potassium currents and Chapter Seven, the calcium current. The experimental work undertaken and the results obtained are then presented and discussed. During the course of this study a number of computer programs were written and tested by the author. The program listings appear in the appendix. The thesis is significant and contributes to the body of knowledge in that no other mathematical model of the unique bursting behaviour of oxytocin-secreting cells exists as far as the author is aware.

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Czudek, Carole. "Post-mortem studies of neurotransmitter systems in schizophrenia." Thesis, University of Nottingham, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.305142.

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Axelrod, Kevin Connor. "Bistable dynamics in microbial ecology and systems biology." Thesis, Harvard University, 2016. http://nrs.harvard.edu/urn-3:HUL.InstRepos:33493470.

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Bistability, in which a system has two stable states, is a common property of many dynamic systems. This thesis explores the properties of such systems across a range of length scales, from gene circuits to ecosystems. Cells often store memories of environmental stimuli using bistable gene circuits. High fidelity memory storage requires that a state has a long lifetime. However, an underappreciated aspect of stable memory is that the distance from a bifurcation could determine how sensitive a state is to perturbations in the extracellular environment. We predict that cell memory should become increasingly sensitive to perturbations near a bifurcation and test this idea in three different gene circuits: a toggle switch, the yeast galactose utilization network, and the E. coli lactose utilization network. In a second study, we explore how the environmental context in which two species interact can influence their mode of interaction. Two species in nature often form reciprocally beneficial partnerships termed mutualisms, but in certain environmental regimes the species might shift to competing with one another for resources. This mutualism-competition transition has been understudied in experimental ecosystems. Using a synthetic yeast cross-feeding mutualism, we modulate the degree to which two partners rely on each other by supplementing the cells with variable amounts of nutrients. Surprisingly, we find that as the amount of supplemented nutrients is increased, the system passes through eight qualitatively distinct dynamic regimes: extinction, obligatory mutualism, obligatory/facultative mutualism, facultative mutualism, parasitism, amensalism, competition, and competitive exclusion. In a third study, we probe how population growth dynamics can influence the probability of evolutionary rescue. Natural populations frequently face harsh environments in which their death rate exceeds their birth rate and population size tends toward zero. In such scenarios, populations can either go extinct, migrate to a better habitat, or adapt to the harsh environment. Natural populations often exhibit an “Allee effect,” in which populations grow slowly at low density due to struggles with such behaviors as finding a mate or collective hunting. We hypothesize that the presence of an Allee effect could impede evolutionary rescue and confirm this hypothesis in a model laboratory yeast ecosystem.<br>Biophysics

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Bradford, Justin A. "Stochastic innovation: Functional self-organization in simple systems." Diss., Search in ProQuest Dissertations & Theses. UC Only, 2008. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3297812.

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Plett, Timothy Stephen. "Ion Transport Phenomena at the Nanoscale in Different Model Battery Systems." Thesis, University of California, Irvine, 2017. http://pqdtopen.proquest.com/#viewpdf?dispub=10287815.

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<p> Lithium ion battery technology has flourished since its introduction into the consumer market. Not only has it helped revolutionize consumer electronics, it also compliments R&D into clean forms of energy harvest e.g. solar, wind, and hydro-electric. As demand for the technology grows, innovative approaches have been taken to improve capacity, output, and lifetime in Li-ion batteries. The approach studied in this research involves the inclusion of nanostructures, which have the potential to significantly increase capacity. While several techniques to fabricate nanostructures are understood, underlying phenomena governing ion transport in and around these nanostructures is only partially understood, which could directly impact design principles for such devices. </p><p> This thesis examines a variety of model systems which could serve to simulate environments found in proposed devices and answer questions regarding ion transport phenomena. The main components we studied from such battery systems were electrolyte and cathode materials. The electrolyte experiences different ion transport phenomena arising from the nanoconfinement of the cathode structures both around and inside the electrode material. Thus, having model systems to examine electrolyte and cathode material separately and in tandem is useful for elucidating phenomena without the challenge of deconvolution resulting from other current-carrying mechanisms. </p><p> Our main tools for carrying out our research were synthetic nanopores. The nanopore structures afforded means to access nanoscale, control environment, and even fabricate components for study. By studying the current-voltage curves in these systems, we were able to draw meaningful conclusions about mechanisms of ion transport in these model systems. The main findings of this research include the inducement of positive surface charge on nanopore structures by organic solvent-based electrolytes by means of dipole and/or ion adsorption, positive evidence of gel electrolyte fitting current models of ion current rectification, and the impact of oxidation state and cycling in cathode material on ion transport through its porous media. Each of these findings is directly related to the thrust of the research and potentially provide insights for future battery design.</p><p>

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Singh, K. D. "The development of biomagnetic systems : planar gradiometers and software tools." Thesis, Open University, 1991. http://oro.open.ac.uk/19786/.

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This thesis is concerned with two aspects of the design and construction of biomagnetic systems. Firstly, it considers the optimum design of planar gradiometers. The modelling of gradiometers is discussed and an algorithm for optimising the sensitivity of a specific type of gradiometer is presented. A test thin-film procedure for the manufacture of a planar gradiometer is outlined. The performance of three different types of gradiometer in recovering test current distributions, using a distributed current analysis technique, is assessed. Secondly, four major software tools that are essential in the analysis of data from large multi-channel biomagnetic systems are presented. These tools are then used to analyze data from a visual evoked response experiment. The system used to collect data was the Helsinki multi-channel system which consists of 24 planar gradiometers. The results confirm the retinotopic mapping of visual field information, and suggest that the time evolution of activity in different parts of the visual cortex is similar for early latencies.

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Books on the topic "Systems biophysics"

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Beard, Daniel A. Chemical biophysics: Quantitative analysis of cellular systems. Cambridge University Press, 2008.

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R, Simms James. Principles of quantitative living systems science. Kluwer Academic/Plenum Publishers, 1999.

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R, Simms James. Principles of quantitative living systems science. Kluwer Academic/Plenum Publishers, 2002.

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Vekshin, N. L. Biophysics of DNA-antibiotic complexes. Nova Science Publishers, 2010.

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Peusner, L. The principles of network thermodynamics: Theory and biophysical applications. Entropy Ltd., 1987.

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Professor, Mishra R. K., ed. Molecular and biological physics of living systems. Kluwer Academic, 1990.

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Goel, Narendra S. Computer simulations of self-organization in biological systems. Croom Helm, 1988., 1988.

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Goel, Narendra S. Computer simulations of self-organization in biological systems. Croom Helm, 1988.

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Noble, Kugler Peter, ed. Self-organization in biological work spaces. North-Holland, 1989.

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M, Becker Oren, ed. Computational biochemistry and biophysics. M. Dekker, 2001.

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Book chapters on the topic "Systems biophysics"

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Parke, William C. "Modeling Biological Systems." In Biophysics. Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-44146-3_13.

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Glaser, Roland. "Molecular Structure of Biological Systems." In Biophysics. Springer Berlin Heidelberg, 2005. http://dx.doi.org/10.1007/978-3-662-04494-0_2.

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Glaser, Roland. "The Kinetics of Biological Systems." In Biophysics. Springer Berlin Heidelberg, 2005. http://dx.doi.org/10.1007/978-3-662-04494-0_5.

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Sybesma, Christiaan. "Biophysics of the sensory systems." In Biophysics. Springer Netherlands, 1989. http://dx.doi.org/10.1007/978-94-009-2239-6_11.

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Glaser, Roland. "Molecular Structure of Biological Systems." In Biophysics. Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-662-45845-7_2.

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Glaser, Roland. "The Kinetics of Biological Systems." In Biophysics. Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-662-45845-7_5.

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Glaser, Roland. "Energetics and Dynamics of Biological Systems." In Biophysics. Springer Berlin Heidelberg, 2005. http://dx.doi.org/10.1007/978-3-662-04494-0_3.

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Glaser, Roland. "Energetics and Dynamics of Biological Systems." In Biophysics. Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-662-45845-7_3.

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Rubin, Andrew, and Galina Riznichenko. "Oscillations, Rhythms, and Chaos in Biological Systems." In Mathematical Biophysics. Springer US, 2013. http://dx.doi.org/10.1007/978-1-4614-8702-9_2.

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Shen, Xun. "Detection of Photon Emission from Biological Systems." In Integrative Biophysics. Springer Netherlands, 2003. http://dx.doi.org/10.1007/978-94-017-0373-4_8.

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Conference papers on the topic "Systems biophysics"

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Duifhuis, H., J. W. Horst, P. van Dijk, and S. M. van Netten. "BIOPHYSICS OF HAIR CELL SENSORY SYSTEMS." In Proceedings of the International Symposium. WORLD SCIENTIFIC, 1993. http://dx.doi.org/10.1142/9789814535274.

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SMITH, CYRIL W. "COHERENCE IN BIOLOGICAL SYSTEMS AND WATER." In Proceedings of the International School of Biophysics. WORLD SCIENTIFIC, 1998. http://dx.doi.org/10.1142/9789812816887_0007.

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J., CAMBAR, DELBANCUT A., and BARROUILLET M. P. "EFFECTS OF METAL HIGH DILUTIONS ON CELLS AND INTEGRATED SYSTEMS." In Proceedings of the International School of Biophysics. WORLD SCIENTIFIC, 1998. http://dx.doi.org/10.1142/9789812816887_0004.

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Ahsan, Fatima, Aravind C. Govindaraju, Robert M. Raphael, et al. "Biophysics of amplitude-modulated giga-hertz electromagnetic waves stimulation." In 2023 57th Asilomar Conference on Signals, Systems, and Computers. IEEE, 2023. http://dx.doi.org/10.1109/ieeeconf59524.2023.10476737.

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Morland, Imogen, Feng Zhu, and Jonathan Leach. "Attosecond-resolution autocorrelator." In Imaging Systems and Applications. Optica Publishing Group, 2022. http://dx.doi.org/10.1364/isa.2022.ith4d.4.

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Measuring target depths has applications in biophysics. We propose a method for measuring the single depth to attosecond resolution within 15 seconds and 32 x 32 pixel depths to nanometre resolution using an autocorrelator.

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Moulin, Thiébaut M. "Principle of «Structural Adaptation» to the Environment: New Applications in Physics and Biophysics." In COMPUTING ANTICIPATORY SYSTEMS: CASYS 2001 - Fifth International Conference. AIP, 2002. http://dx.doi.org/10.1063/1.1503692.

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Kordek, David, Martin Kopecek, and Petr Voda. "Medical biophysics as a combination of the classic educational method and e-learning." In 2017 Federated Conference on Computer Science and Information Systems. IEEE, 2017. http://dx.doi.org/10.15439/2017f369.

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Konev, Yuri B., and Boris A. Kuzyakov. "Gas lenses as nonlinear optical elements for laser cosmic energy systems." In ICONO '98: Laser Spectroscopy and Optical Diagnostics--Novel Trends and Applications in Laser Chemistry, Biophysics, and Biomedicine, edited by Sergei S. Chesnokov, Valerii P. Kandidov, and Nikolai I. Koroteev. SPIE, 1999. http://dx.doi.org/10.1117/12.340070.

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Meaud, Julien, Thomas Bowling, and Charlsie Lemons. "Computational Modeling of Spontaneous Otoacoustic Emissions by the Mammalian Cochlea." In ASME 2018 Dynamic Systems and Control Conference. American Society of Mechanical Engineers, 2018. http://dx.doi.org/10.1115/dscc2018-9044.

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The mammalian cochlea is a sensory system with high sensitivity, sharp frequency selectivity and a broad dynamic range. These characteristics are due to the active nonlinear feedback by outer hair cells. Because it is an active nonlinear system, the cochlea sometimes emits spontaneous otoacoustic emissions (SOAEs) that are generated in the absence of any external stimulus due to the emergence of limit cycle oscillations. In this work, we use a computational physics-based model of the mammalian cochlea to investigate the generation of SOAEs. This model includes a three-dimensional model of the fluid mechanics in the cochlear ducts, a micromechanical model for the vibrations of the cochlear structures, and a realistic model of outer hair cell biophysics. Direct simulations of SOAEs in the time-domain demonstrate that the model is able to capture key experimental observations regarding SOAEs. Parametric studies and analysis of model simulations are used to demonstrate that SOAEs are a global phenomenon that arises due to the collective action of a distributed region of the cochlea rather than from spontaneous oscillations from individual outer hair cells.

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Chen, T., H. Dietz, V. Engel, et al. "Femtosecond spectroscopy on simple molecular systems: pump-probe and four-wave mixing techniques." In ICONO '98: Laser Spectroscopy and Optical Diagnostics--Novel Trends and Applications in Laser Chemistry, Biophysics, and Biomedicine, edited by Sergei S. Chesnokov, Valerii P. Kandidov, and Nikolai I. Koroteev. SPIE, 1999. http://dx.doi.org/10.1117/12.340043.

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Reports on the topic "Systems biophysics"

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Hansmann, Ulrich H. E. Final report for Conference Support Grant "From Computational Biophysics to Systems Biology - CBSB12". Office of Scientific and Technical Information (OSTI), 2012. http://dx.doi.org/10.2172/1059268.

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Terwilliger, Thomas C., Paul D. Adams, David Baker, et al. Advances, Interactions, and Future Developments in the CNS, Phenix, and Rosetta Structural Biology Software Systems Annual Review of Biophysics. Office of Scientific and Technical Information (OSTI), 2012. http://dx.doi.org/10.2172/1051070.

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Vaidya, Ramesh A., Arun B. Shrestha, Santosh Nepal, and Kanchan Shrestha. The Koshi River basin: A biophysical and socioeconomic overview; Resource Book. International Centre for Integrated Mountain Development (ICIMOD), 2022. http://dx.doi.org/10.53055/icimod.1008.

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The Koshi River basin resource book presents an analysis of the complexities inherent in effectively managing water resources. It collates current knowledge on the Koshi basin’s water resource system and related ecosystems, their uses and users, and integrated governance mechanisms. Building on these, it presents possible approaches for water management at different scales. The authors identify key knowledge gaps and provide specific recommendations that may be useful for policy makers, administrators, development workers, and researchers working on addressing water resource management issues in the basin.

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Potter, Adam, Anthony J. Karis, and Julio A. Gonzalez. Comparison of Biophysical Characteristics and Predicted Thermophysiological Responses of Three Prototype Body Armor Systems Versus Baseline U.S. Army Body Armor Systems. Defense Technical Information Center, 2015. http://dx.doi.org/10.21236/ada619765.

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Koch, Christof. Dynamic Biophysical Theory for the Role of Hippocampal Neural Networks in the Declarative Memory System. Defense Technical Information Center, 1992. http://dx.doi.org/10.21236/ada279961.

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Ronneberger, Kerstin, Maria Berrittella, Francesco Bosello, and Richard Tol. KLUM@GTAP: Spatially-Explicit, Biophysical Land Use in a Computable General Equilibrium Model. GTAP Working Paper, 2008. http://dx.doi.org/10.21642/gtap.wp50.

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*Chapter 12 of the forthcoming book "Economic Analysis of Land Use in Global Climate Change Policy," edited by Thomas W. Hertel, Steven Rose, and Richard S.J. Tol In this paper the global agricultural land use model KLUM is coupled to an extended version of the computable general equilibrium model (CGE) GTAP in order to consistently assess the integrated impacts of climate change on global cropland allocation and its implications for economic development. The methodology is innovative as it introduces dynamic economic land-use decisions based also on the biophysical aspects of land into a state-of the-art CGE; it further allows the projection of resulting changes in cropland patterns at a spatially explicit level. A convergence test and illustrative future simulations underpin the robustness analysis and serve to highlight the potential of the coupled system. Reference simulations with the uncoupled models emphasize the impact and relevance of the coupling; the results of coupled and uncoupled simulations can differ by several hundred percent.

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Azem, Abdussalam, George Lorimer, and Adina Breiman. Molecular and in vivo Functions of the Chloroplast Chaperonins. United States Department of Agriculture, 2011. http://dx.doi.org/10.32747/2011.7697111.bard.

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We present here the final report for our research project entitled "The molecular and in vivo functions of the chloroplast chaperonins”. Over the past few decades, intensive investigation of the bacterial GroELS system has led to a basic understanding of how chaperonins refold denatured proteins. However, the parallel is limited in its relevance to plant chaperonins, since the plant system differs from GroEL in genetic complexity, physiological roles of the chaperonins and precise molecular structure. Due to the importance of plant chaperonins for chloroplast biogenesis and Rubisco assembly, research on this topic will have implications for many vital applicative fields such as crop hardiness and efficiency of plant growth as well as the production of alternative energy sources. In this study, we set out to investigate the structure and function of chloroplast chaperonins from A. thaliana. Most plants harbor multiple genes for chaperonin proteins, making analysis of plant chaperonin systems more complicated than the GroEL-GroES system. We decided to focus on the chaperonins from A. thaliana since the genome of this plant has been well defined and many materials are available which can help facilitate studies using this system. Our proposal put forward a number of goals including cloning, purification, and characterization of the chloroplast cpn60 subunits, antibody preparation, gene expression patterns, in vivo analysis of oligomer composition, preparation and characterization of plant deletion mutants, identification of substrate proteins and biophysical studies. In this report, we describe the progress we have made in understanding the structure and function of chloroplast chaperonins in each of these categories.

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Kokurina, Olga Yu. SOCIETAL-METABOLIC SYSTEM OF THE STATE: EXPERIENCE OF SYNTHETIC RESEARCH. THE ELECTRONIC MANUAL. SIB-Expertise, 2023. http://dx.doi.org/10.12731/er0756.18122023.

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This electronic manual presents a number of theoretical and methodological tools based on the key concept: “societal (social) metabolism.” In summary, the synthetic concept of societal metabolism goes beyond the perspective of traditional social sciences by contextualizing the biophysical dimension of metabolic exchange between society and nature. Distancing from reductionist approaches, the interdisciplinary concept of societal metabolism recognizes the importance of mutual connections and interactions of factors of material and social exchange, within the framework of established individual and group social practices in the life of society. The electronic manual will be useful to undergraduate and graduate students studying social and political sciences, and to anyone interested in the theory and practice of applying interdisciplinary approaches to social science problems.

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Webster, D. G. Chesapeake Governance Study: Report of 2021 Decision Maker Interview Results. Dartmouth Digital Commons, 2022. http://dx.doi.org/10.1349/zylh8682.

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This report describes the aggregate results from a series of interviews conducted with decision makers involved in governance of the Chesapeake Watershed. Interviews began in June and ended in December of 2021. Information collected will be combined with other data to create and then test a computer model to predict likely policy changes under a range of future scenarios. It is part of a larger project funded by the National Science Foundation called Modeling the Dynamics of Human and Estuarine Systems with Regulatory Feedbacks (Award #2009248). Using the Chesapeake Bay as an example, this project will combine the policy model that we are designing with biophysical models to predict how social, economic and policy changes impact water quality, and how changes in water quality influence human behavior and decision-making.

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Moran, Nava, Richard Crain, and Wolf-Dieter Reiter. Regulation by Light of Plant Potassium Uptake through K Channels: Biochemical, Physiological and Biophysical Study. United States Department of Agriculture, 1995. http://dx.doi.org/10.32747/1995.7571356.bard.

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The swelling of plant motor cells is regulated by various signals with almost unknown mediators. One of the obligatory steps in the signaling cascade is the activation of K+-influx channels -K+ channels activated by hyperpolarization (KH channels). We thus explored the regulation of these channels in our model system, motor cell protoplasts from Samanea saman, using patch-clamp in the "whole cell" configuration. (a) The most novel finding was that the activity of KH channels in situ varied with the time of the day, in positive correlation with cell swelling: in Extensor cells KH channels were active in the earlier part of the day, while in Flexor cells only during the later part of the day; (b) High internal pH promoted the activity of these channels in Extensor cells, opposite to the behavior of the equivalent channels in guard cells, but in conformity with the predicted behavior of the putative KH channel, cloned from S. saman recently; (c) HIgh external K+ concentration increased (KH channel currents in Flexor cells. BL depolarized the Flexor cells, as detected in cell-attached patch-clamp recording, using KD channels (the K+-efflux channels) as "voltage-sensing devices". Subsequent Red-Light (RL) pulse followed by Darkness, hyperpolarized the cell. We attribute these changes to the inhibition of the H+-pump by BL and its reactivation by RL, as they were abolished by an H+-pump inhibitor. BL increased also the activity KD channels, in a voltage-independent manner - in all probability by an independent signaling pathway. Blue-Light (BL), which stimulates shrinking of Flexor cells, evoked the IP3 signaling cascade (detected directly by IP3 binding assay), known to mobilize cytosolic Ca2+. Nevertheless, cytosolic Ca2+ . did not activate the KD channel in excised, inside-out patches. In this study we established a close functional similarity of the KD channels between Flexor and Extensior cells. Thus the differences in their responses must stem from different links to signaling in both cell types.

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