Relevant bibliographies by topics / Systems pharmacology

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Systems pharmacology'

Author: Grafiati
Published: 4 June 2021
Last updated: 26 July 2025

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Journal articles on the topic "Systems pharmacology"

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Boran, Aislyn D. W., and Ravi Iyengar. "Systems Pharmacology." Mount Sinai Journal of Medicine: A Journal of Translational and Personalized Medicine 77, no. 4 (2010): 333–44. http://dx.doi.org/10.1002/msj.20191.

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Mortin, Lawrence I., Christopher J. Horvath, and Michael S. Wyand. "Safety Pharmacology Screening: Practical Problems in Drug Development." International Journal of Toxicology 16, no. 1 (1997): 41–65. http://dx.doi.org/10.1080/109158197227350.

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Undesired pharmacologic activities of novel drugs or biologies may limit development of a therapeutic prior to the characterization of any toxicologic effects. In rodent species, general pharmacology assays have traditionally been used to screen new agents for pharmacologic effects on the central and peripheral nervous systems, the autonomic nervous system and smooth muscles, the respiratory and cardiovascular systems, the digestive system, and the physiologic mechanisms of water and electrolyte balance. In large animal species, such as dogs and nonhuman primates, smaller numbers of animals pe
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Atkinson, A. J., and P. M. Lyster. "Systems Clinical Pharmacology." Clinical Pharmacology & Therapeutics 88, no. 1 (2010): 3–6. http://dx.doi.org/10.1038/clpt.2010.88.

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Berg, J. M., M. E. Rogers, and P. M. Lyster. "Systems Biology and Pharmacology." Clinical Pharmacology & Therapeutics 88, no. 1 (2010): 17–19. http://dx.doi.org/10.1038/clpt.2010.69.

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Chen, Yu, Timothy S. Kern, Philip D. Kiser, and Krzysztof Palczewski. "Eyes on systems pharmacology." Pharmacological Research 114 (December 2016): 39–41. http://dx.doi.org/10.1016/j.phrs.2016.09.026.

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Berger, S. I., A. Ma'ayan, and R. Iyengar. "Systems Pharmacology of Arrhythmias." Science Signaling 3, no. 118 (2010): ra30. http://dx.doi.org/10.1126/scisignal.2000723.

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van der Graaf, Piet H. "Systems Pharmacology and Pharmacodynamics." CPT: Pharmacometrics & Systems Pharmacology 6, no. 12 (2017): 803. http://dx.doi.org/10.1002/psp4.12231.

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Kaddurah-Daouk, R., and R. M. Weinshilboum. "Pharmacometabolomics: Implications for Clinical Pharmacology and Systems Pharmacology." Clinical Pharmacology & Therapeutics 95, no. 2 (2013): 154–67. http://dx.doi.org/10.1038/clpt.2013.217.

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Panteleev, M. A., A. N. Sveshnikova, A. V. Belyaev, et al. "Systems Biology and Systems Pharmacology of Thrombosis." Mathematical Modelling of Natural Phenomena 9, no. 6 (2014): 4–16. http://dx.doi.org/10.1051/mmnp/20149602.

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Gadkar, K., D. Kirouac, N. Parrott, and S. Ramanujan. "Quantitative systems pharmacology: a promising approach for translational pharmacology." Drug Discovery Today: Technologies 21-22 (September 2016): 57–65. http://dx.doi.org/10.1016/j.ddtec.2016.11.001.

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Dissertations / Theses on the topic "Systems pharmacology"

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Duran-Frigola, Miquel 1985. "Blending biology and chemistry to enable systems pharmacology." Doctoral thesis, Universitat Pompeu Fabra, 2016. http://hdl.handle.net/10803/459111.

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The avalanche of data that followed the sequencing of the human genome has revealed an overwhelming biological complexity. No simple molecular explanation exists for most of the diseases and, in consequence, simple therapies have low probability of success. The emerging field of systems pharmacology seeks drugs of broad impact on molecular networks. To achieve so, it is necessary to integrate heterogeneous data, at different levels of complexity, and find correlations between them. This translational exercise is, perhaps, the major concern of current biomedical research. In this Thesis we und
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Kuenzi, Brent M. "Off-Target Based Drug Repurposing Using Systems Pharmacology." Scholar Commons, 2018. https://scholarcommons.usf.edu/etd/7689.

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The goal of this study was to identify novel drug repurposing opportunities in cancer by utilizing the off-target profiles of clinically relevant kinase inhibitors. This was based on the observation that the global target profiles of compounds are largely ignored and that many compounds have activity that cannot be explained by their cognate target alone. Additionally, by utilizing clinically relevant compounds, any results would hold a high potential for eventual clinical implementation. We utilized a systems pharmacology approach utilizing cell viability-based drug screening to identify comp
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Knight, Anthony. "A systems pharmacology approach to the adenosine A1 receptor." Thesis, University of Warwick, 2015. http://wrap.warwick.ac.uk/75201/.

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The majority of drugs are prescribed on the premise that their desired and undesired effects are well characterised. However, the mechanisms underlying these effects can be elusive and are of interest to the pharmaceutical industry in terms of rational drug design. G protein-coupled receptors are a significant class of drug target that are capable of influencing multiple signalling processes, and downstream effects, simultaneously through a variety of effectors, such as G proteins or –β-arrestins. The effector activated by a given receptor is often a function of the ligand. This is termed func
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Knight-Schrijver, Vincent. "Towards systems pharmacology models of druggable targets and disease mechanisms." Thesis, University of Cambridge, 2019. https://www.repository.cam.ac.uk/handle/1810/289731.

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The development of essential medicines is being slowed by a lack of efficiency in drug development as ninety per cent of drugs fail at some stage during clinical evaluation. This attrition in drug development is seen not because of a reduction in pharmaceutical research expenditure nor is it caused by a declining understanding of biology, if anything, these are both increasing. Instead, drugs are failing because we are unable to effectively predict how they will work before they are given to patients. This is due to limitations of the current methods used to evaluate a drug's toxicity and effi
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Shahid, Mohammad [Verfasser]. "Integrative Systems Approaches Towards Brain Pharmacology and Polypharmacology / Mohammad Shahid." Bonn : Universitäts- und Landesbibliothek Bonn, 2014. http://d-nb.info/1051028175/34.

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Kelly, R. A. "Biochemical thermodynamic modelling of cellular bioenergetics : a quantitative systems pharmacology approach." Thesis, Liverpool John Moores University, 2018. http://researchonline.ljmu.ac.uk/7754/.

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In this thesis, thermodynamic-based mathematical modelling is combined with experimental in vitro extracellular flux analysis in order to assess drug redox cycling and cellular bioenergetics. It is widely accepted that pharmacological activity of certain classes of drugs (e.g. anticancer, antimalarial) is related to their ability to accept one or two electrons. However, pharmacological activity via redox cycling is an understated mechanism of toxicity associated with many classes of drugs. In particular, oxidative stress as a result of redox cycling plays a pivotal role in the cause of cardiac
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Stockmeier, Craig A., and Gregory A. Ordway. "Interactions of Norepinephrine With Other Neurotransmitter Systems: Anatomical Basis and Pharmacology." Digital Commons @ East Tennessee State University, 2007. https://dc.etsu.edu/etsu-works/8614.

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Introduction Norepinephrine-containing neurons clustered within the locus coeruleus (LC) provide most of the norepinephrine present within the central nervous system. These cells have tonic pacemaker activity and this activity is regulated by a variety of neurotransmitter inputs. The focus of this review is primarily on classical, non-neuropeptide, neurotransmitter input to the LC and the reciprocal projections of noradrenergic neurons to those classical neurotransmitter systems. Input to the LC from serotonin-, dopamine-, γ-aminobutyric acid (GABA)-, glutamate-, and acetylcholine-containing n
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Ali, Habib. "Engineering liposomal systems to develop solubility enhancing technology." Thesis, Aston University, 2008. http://publications.aston.ac.uk/15264/.

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This research primarily focused on identifying the formulation parameters which control the efficacy of liposomes as delivery systems to enhance the delivery of poorly soluble drugs. Preliminary studies focused on the drug loading of ibuprofen within vesicle systems. Initially both liposomal and niosomal formulations were screened for their drug-loading capacity: liposomal systems were shown to offer significantly higher ibuprofen loading and thereafter lipid based systems were further investigated. Given the key role cholesterol is known to play within the stability of bilayer vesicles. the o
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Carruthers, Alan Mark. "Metabotropic glutamate receptor pharmacology and signalling in model and neuronal cell systems." Thesis, University of Leicester, 1997. http://hdl.handle.net/2381/29926.

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In rat cerebellar granule cells measurement of phosphoinositide turnover and cAMP formation revealed that mGluR effects on these two parameters were developmentally regulated. Inhibitory effects on cAMP formation and phosphoinositide turnover increased in parallel followed by a decline to lower values coinciding with an increased sensitivity of the neurons to NMDA and L-glutamate excitotoxicity. Phosphoinositide responses mediated by group I mGluRs present on cerebellar granule neurons (thought previously to be predominantly mediated by mGluR1 in these cells) were insensitive to pertussis toxi
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Jenner, Simon, and Dennis Amphan. "Linking Systems Models of Pharmacology with Behavioural Models of Adherence : A Feasibility Study." Thesis, KTH, Medicinteknik och hälsosystem, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-278166.

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Pharmacokinetic (PK)- and pharmacodynamic (PD) modeling are useful tools whenassessing treatment effect. A patient’s adherence can potentially be rate-limiting, since it isthe first process in a chain of processes that determines treatment effect. Therefore agreater system taking into consideration PKPD as well as adherence models couldpotentially unlock a greater system understanding. This study focuses on investigating thefeasibility of combining models concerning adherence, PK and PD. An extensive mapping of previously made work on the topics of PKPD model developmentand adherence models co
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Books on the topic "Systems pharmacology"

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Mager, Donald E., and Holly H. C. Kimko, eds. Systems Pharmacology and Pharmacodynamics. Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-44534-2.

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Richardson, Rudy J., and Dale E. Johnson, eds. Computational Systems Pharmacology and Toxicology. Royal Society of Chemistry, 2017. http://dx.doi.org/10.1039/9781782623731.

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D'Argenio, David Z. Advanced methods of pharmakinetic and pharmacodynamic systems analysis. Kluwer, 2004.

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Kenakin, Terry, and James A. Angus, eds. The Pharmacology of Functional, Biochemical, and Recombinant Receptor Systems. Springer Berlin Heidelberg, 2000. http://dx.doi.org/10.1007/978-3-642-57081-0.

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Gregoriadis, Gregory, and Brenda McCormack. Targeting of Drugs 6: Strategies for stealth therapeutic systems. Springer, 1998.

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Biomedical Simulations Resource Workshop on Advanced Methods of Pharmacokinetic and Pharmacodynamic Systems Analysis (1990 Marina del Rey, Calif.). Advanced methods of pharmacokinetic and pharmacodynamic systems analysis. Plenum Press, 1991.

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International Symposium on Biosignalling in Cardiac and Vascular Systems (1988 Kyoto, Japan). Biosignalling in cardiac and vascular systems: Proceedings of the International Symposium on Biosignalling in Cardiac and Vascular Systems, 5-7 September, 1988, Kyoto, Japan. Pergamon Press, 1989.

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Bernkop-Schnürch, Andreas. Oral delivery of macromolecular drugs: Barriers, strategies, and future trends. Springer, 2009.

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Patrick, Augustijns, and Brewster Marcus, eds. Solvent systems and their selection in pharmaceutics and biopharmaceutics. Springer, 2007.

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N, Dalby Richard, ed. Respiratory drug delivery VI: Biological, pharmaceutical, clinical and regulatory issues relating to optimized drug delivery by aerosol. Interpharm Press, 1998.

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Book chapters on the topic "Systems pharmacology"

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Zhao, Shan, and Ravi Iyengar. "Systems Pharmacology." In Encyclopedia of Systems Biology. Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4419-9863-7_574.

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Wotring, Virginia E. "Multiple Systems Spaceflight Effects." In Space Pharmacology. Springer US, 2012. http://dx.doi.org/10.1007/978-1-4614-3396-5_9.

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Birtwistle, Marc R., Jens Hansen, James M. Gallo, et al. "Systems Pharmacology: An Overview." In Systems Pharmacology and Pharmacodynamics. Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-44534-2_4.

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Lefkowitz, Stanley S. "Drug Abuse Effects on the Reticuloendothelial and Immune Systems." In Pharmacology. Springer US, 1985. http://dx.doi.org/10.1007/978-1-4615-9406-2_16.

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Reinscheid, Rainer K., and Stefan Schulz. "Opioid Systems." In Encyclopedia of Molecular Pharmacology. Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-21573-6_108-1.

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Reinscheid, Rainer K., and Stefan Schulz. "Opioid Systems." In Encyclopedia of Molecular Pharmacology. Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-57401-7_108.

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Schwartz, Jean-Marc, and Jose C. Nacher. "Systems Pharmacology, Drug Disease Interactions." In Encyclopedia of Systems Biology. Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4419-9863-7_575.

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Nacher, Jose C., and Jean-Marc Schwartz. "Systems Pharmacology, Drug-Target Networks." In Encyclopedia of Systems Biology. Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4419-9863-7_576.

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Wang, Christina, and Ronald S. Swerdloff. "Androgen Pharmacology and Delivery Systems." In Androgens in Health and Disease. Humana Press, 2003. http://dx.doi.org/10.1007/978-1-59259-388-0_8.

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Mahajan, Vineet. "Liver Systems in Safety Pharmacology." In Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays. Springer International Publishing, 2024. http://dx.doi.org/10.1007/978-3-031-35529-5_64.

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Conference papers on the topic "Systems pharmacology"

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Borodin, Yuriy I., Lybov N. Rachkovskaya, Tatyana V. Popova, et al. "Modified Sorbents for Pharmacology." In 2018 11th International Multiconference Bioinformatics of Genome Regulation and Structure\Systems Biology (BGRS\SB). IEEE, 2018. http://dx.doi.org/10.1109/csgb.2018.8544763.

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Topunov, A. F., O. V. Kosmachevskaya, and O. E. Bagrova. "ENZYMATIC SYSTEMS FOR REDUCTION OF HEMOGLOBINS." In NOVEL TECHNOLOGIES IN MEDICINE, BIOLOGY, PHARMACOLOGY AND ECOLOGY. LLC Institute Information Technologies, 2024. http://dx.doi.org/10.47501/978-5-6044060-4-5.73-77.

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The view on the reductase systems supporting hemoglobin in physiologically active reduced state is providing. The existence of such reductase systems is essential for functioning of all hemoglobins. They can be special reductases, reductase domains, connected with globin molecule, and reductas-es of wide spectrum of activitie for which reduction of hemoglobin is one of possible functions.
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LIU, EDISON. "SYSTEMS PHARMACOLOGY IN CANCER THERAPEUTICS: ITERATIVE INFORMATICS-EXPERIMENTAL INTERFACE." In Proceedings of the 3rd Annual RECOMB Workshop. PUBLISHED BY IMPERIAL COLLEGE PRESS AND DISTRIBUTED BY WORLD SCIENTIFIC PUBLISHING CO., 2008. http://dx.doi.org/10.1142/9781848162525_0008.

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Dzhimak, Stepan S., Anna Elkina, and Alexandr A. Basov. "MECHANISMS OF FRACTIONATION OF STABLE ISOTOPES IN LIVING SYSTEMS." In NEW TECHNOLOGIES IN MEDICINE, BIOLOGY, PHARMACOLOGY AND ECOLOGY. Institute of information technology, 2021. http://dx.doi.org/10.47501/978-5-6044060-1-4.17.

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Some physical laws are considered that provide stable fractionation of isotopes, leading to the accumulation of certain isotopic forms in the intracellular and intercellular space with the manifestation of these effects at various levels of the organism. It is suggested that for a more complete understanding of the above processes, it is necessary to study the mechanism of exchange interaction between particles with integer spin (bosons) and half-integer spin (fermions).
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Murashkina, T. I., and V. A. Badeev. "MEASUREMENT OF LIQUID QUALITY PARAMETERS IN LIFE SUPPORT SYSTEMS." In NOVEL TECHNOLOGIES IN MEDICINE, BIOLOGY, PHARMACOLOGY AND ECOLOGY. LLC Institute Information Technologies, 2024. http://dx.doi.org/10.47501/978-5-6044060-4-5.135-139.

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The use of a fiber-optic refractometric micro-sensor for quality control of liquids in life sup-port systems of medical institutions and spacecraft, the principle of operation of which is based on measuring changes in the refractive index of liquids, is justified.
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Kosmachevskaya, O. V., E. I. Nasybullina, I. S. Pugachenko, et al. "EFFECT OF NITROSYL IRON COMPLEXES IN HEMOGLOBIN-CONTAINING SYSTEMS." In NOVEL TECHNOLOGIES IN MEDICINE, BIOLOGY, PHARMACOLOGY AND ECOLOGY. LLC Institute Information Technologies, 2024. http://dx.doi.org/10.47501/978-5-6044060-4-5.81-87.

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Nitrosyl iron complexes with glutathione, phosphate and thiosulfate ligands inhibited the produc-tion of free radical intermediates in the oxidation of hemoglobin with tert-butyl hydroperoxide, and also prevented the oxidative modification of hemoglobin. Tetranitrosyl iron complex (TNIC) was a more effective antioxidant compared to other studied complexes.
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Kosmachevskaya, O. V., E. I. Nasybullina, I. S. Pugachenko, K. B. Shumaev, N. N. Novikova, and A. F. Topunov. "PROTECTIVE ACTION OF GLUTATHIONE DINITROSYL IRON COMPLEXES IN HEMOGLOBIN-CONTAINING SYSTEMS." In NOVEL TECHNOLOGIES IN MEDICINE, BIOLOGY, PHARMACOLOGY AND ECOLOGY. LLC Institute Information Technologies, 2023. http://dx.doi.org/10.47501/978-5-6044060-3-8.126-131.

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Glutathione dinitrosyl iron complexes (GS-DNICs) effectively protected hemoglobin from ox-idative modification. They prevented the formation of carbonyl derivatives, oxidation of tryp-tophan and tyrosine residues, degradation of heme group, as well as the formation of protein crosslinking. GS-DNICs inhibited erythrocyte lysis induced by HOCl.
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Sanina, N. A. "NITROSYL FERREDOXINS MIMETICS AS PROMISING VASODILATORS IN REACTIONS WITH MODEL BIOLOGICAL SYSTEMS." In NOVEL TECHNOLOGIES IN MEDICINE, BIOLOGY, PHARMACOLOGY AND ECOLOGY. LLC Institute Information Technologies, 2024. http://dx.doi.org/10.47501/978-5-6044060-4-5.240-245.

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The paper presents data on the study of the interaction of original mimetics of nitrosyl [2Fe-2S] ferredoxins as donors of nitric oxide (NO) with model biological systems (serum albumin, mucin, hemoglobin, glutathione and cyclic nucleotides) using modern experimental and theo-retical methods.
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Zvereva, E. A., O. D. Hendrickson, A. V. Zherdev, and B. B. Dzantiev. "IMMUNOCHROMATOGRAPHIC TEST SYSTEMS FOR RAPID OUT-OF-LABORATORY CONTROL OF THE COMPOSITION OF MEAT FOODS." In NOVEL TECHNOLOGIES IN MEDICINE, BIOLOGY, PHARMACOLOGY AND ECOLOGY. Institute of information technology, 2022. http://dx.doi.org/10.47501/978-5-6044060-2-1.68-73.

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The article discusses the developed immunochromatographic test systems for the identification of raw materials in the production of meat products based on the detection of protein bi-omarkers troponin I, myoglobin, immunoglobulins. The possibilities of these systems for as-sessing the content of different types of raw materials (composition control) are considered. Data on the reproducibility of photometric measurements have been obtained. Approbation of the developed test systems for the characteristics of meat food products, evaluation of their effectiveness for composition control was carri
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Badeeva, Elena, Tatyana Murashkina, Ilya Slavkin, Roman Viktorovich Kostin, and Elena Andreevna Shachneva. "INSTALLATION FOR RAPID RESEARCH OF A FIBER-OPTIC SENSOR LIQUID FLOW RATES FOR LIFE SUPPORT SYSTEMS." In NEW TECHNOLOGIES IN MEDICINE, BIOLOGY, PHARMACOLOGY AND ECOLOGY. Institute of information technology, 2021. http://dx.doi.org/10.47501/978-5-6044060-1-4.03.

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The article proposes a block diagram and a simplified design of a device for reproducing and measuring the parameters of liquid flows (velocity, flow, volume), carried out during the adjustment and adjustment of the optical system, express calibration and express studies of fi-ber-optic sensors of liquid flow parameters(FOSLFP). A variant of installing a FOSLFP on the pipeline section in the life support system is proposed.
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Reports on the topic "Systems pharmacology"

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Wang, Qin, Xinya Peng, and Congchao Jia. Efficacy and Pharmacological Mechanism of Poria cocos-based Formulas Combined with Chemotherapy for Ovarian Cancer: A Integrated Systems Pharmacology Study. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2021. http://dx.doi.org/10.37766/inplasy2021.8.0060.

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Keating, Louise, Ailish Malone Name, Maire-Brid Casey, Ciaran Bolger, Dara Meldrum, and Catherine Doody. Conservative Primary Care Management for Recent Onset Cervical Radiculopathy – a Systematic Review & Meta-analysis Protocol. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2022. http://dx.doi.org/10.37766/inplasy2022.2.0047.

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Review question / Objective: To investigate the effectiveness of conservative management available in primary care for adults with recent onset (less than 12 weeks) cervical radiculopathy. Conservative management will be compared to any available comparator i.e. no treatment, placebo or any treatment. Eligibility criteria: Inclusion criteria – trials (as defined in item 15) investigating any conservative management (e.g. exercise, advice, manual therapy, traction, acupuncture, pharmacology etc), involving adults with single level CR (as defined in item 10) of any aetiology, with symptom durati
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