Relevant bibliographies by topics / T (8;21)

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Academic literature on the topic 'T (8;21)'

Author: Grafiati
Published: 4 June 2021
Last updated: 2 February 2022

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Journal articles on the topic "T (8;21)"

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Maslak, P. "AML with t(8; 21)." ASH Image Bank 2004, no. 0524 (May 24, 2004): 101125. http://dx.doi.org/10.1182/ashimagebank-2004-101125.

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Maslak, P. "AML with t(8:21)." ASH Image Bank 2001, no. 1205 (December 5, 2001): 100215. http://dx.doi.org/10.1182/ashimagebank-2001-100215.

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Yang, Genyan, Waleed Khalaf, Louis van de Locht, Joop H. Jansen, Bert A. van der Reijden, Carsten Müller-Tidow, H. Ruud Delwel, Hubert Serve, D. Wade Clapp, and Scott W. Hiebert. "Epigenetic regulation of tumor suppressors in t(8:21)-containing AML." Annals of Hematology 83, no. 6 (March 30, 2004): 329–30. http://dx.doi.org/10.1007/s00277-003-0841-8.

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Somjee, Saika, Anupama Borker, Renee Gardner, and Maria C. Velez. "Multiple Granulocytic Sarcomas in Acute Myeloblastic Leukemia with Simultaneous Occurrence of t(8:21) and Trisomy 8." Leukemia & Lymphoma 42, no. 5 (January 2001): 1139–44. http://dx.doi.org/10.3109/10428190109097737.

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Gadage, VS, KS Galani, PS Kadam Amare, and N. Mittal. "Systemic mastocytosis with associated acute myeloid leukemia with t (8; 21) (q22; q22)." Indian Journal of Pathology and Microbiology 55, no. 3 (2012): 409. http://dx.doi.org/10.4103/0377-4929.101761.

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Gujral, Sumeet, Nikhil Rabade, Prashant Tembhare, Nikhil Patkar, Pratibha Amare, Brijesh Arora, and PG Subramanian. "'Childhood systemic mastocytosis associated with t (8; 21) (q22; q22) acute myeloid leukemia'." Indian Journal of Pathology and Microbiology 59, no. 3 (2016): 407. http://dx.doi.org/10.4103/0377-4929.188140.

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Zhang, Weina, Ying Lu, Tao Zhen, Xinjie Chen, Ming Zhang, Ping Liu, Xiangqin Weng, Bing Chen, and Yueying Wang. "Homoharringtonine synergy with oridonin in treatment of t(8; 21) acute myeloid leukemia." Frontiers of Medicine 13, no. 3 (June 2019): 388–97. http://dx.doi.org/10.1007/s11684-018-0624-1.

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Moghimi, Ali, Alan Mills, and Cathrine Mitchell. "21. Peripheral T-cell lymphoma with follicular pattern: a ‘real’ entity." Pathology 43 (2011): S95. http://dx.doi.org/10.1016/s0031-3025(16)33309-8.

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Tighe, Jane E., and Franco Calabi. "t(8;21) Breakpoints are Clustered between Alternatively Spliced Exons of MTG8." Clinical Science 89, no. 3 (September 1, 1995): 215–18. http://dx.doi.org/10.1042/cs0890215.

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1. The (8;21) translocation, which is consistently associated with a subgroup of acute myeloid leukaemia, involves two loci: runt on chromosome 21 and MTG8 on chromosome 8. 2. Breakpoints in runt fall within a single intron that is located immediately downstream of a phylogenetically conserved DNA-binding domain (the ‘runt box’). 3. We now show that most breakpoints on chromosome 8 fall within a region between two alternative 5′ MTG8 exons. Thus, we predict that chimaeric genes on both the derivative(8) and the derivative(21) chromosomes have the potential to be transcriptionally active.
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Sano, Hitoshi, Kentaro Ohki, Myoung-ja Park, Norio Shiba, Yusuke Hara, Manabu Sotomatsu, Daisuke Tomizawa, et al. "CSF3RandCALRmutations in paediatric myeloid disorders and the association ofCSF3Rmutations with translocations, including t(8; 21)." British Journal of Haematology 170, no. 3 (April 9, 2015): 391–97. http://dx.doi.org/10.1111/bjh.13439.

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Books on the topic "T (8;21)"

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United States. Congress. Senate. Committee on Armed Services. Nominations before the Senate Armed Services Committee, second session, 108th Congress: Hearings before the Committee on Armed Services, United States Senate, One Hundred Eighth Congress, second session, on nominations of Francis J. Harvey; Lawrence T. Di Rita; William A. Chatfield; Tina Westby Jonas; Dionel M. Aviles; Jerald S. Paul; Mark Falcoff; GEN George W. Casey, Jr., USA; ADM Vernon E. Clark, USN; Lt. Gen. James E. Cartwright, USMC; VADM Timothy J. Keating, USN; LTG Bantz J. Craddock, USA; Peter Cyril Wyche Flory; Valerie Lynn Baldwin; Dr. Francis J. Harvy; Richard Greco, Jr.; Gen. Gregory S. Martin, USAF; Joseph F. Bader; R. Bruce Matthews; Otis W. Brawley; and Vinicio E. Madrigal, January 28, February 4, April 27, May 11, June 24, July 8, 21, October 6, November 17, 2004. Washington: U.S. G.P.O., 2005.

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Book chapters on the topic "T (8;21)"

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Lieber, Michael R., and Theodore L. Steck. "[21] Hemolytic holes in human erythrocyte membrane ghosts." In Biomembranes Part T, 356–67. Elsevier, 1989. http://dx.doi.org/10.1016/s0076-6879(89)73023-8.

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"AML with t(8 ;21 )(q22;q22) ; RUNX1-RUNX1T1." In Bone Marrow, 115–16. CRC Press, 2011. http://dx.doi.org/10.1201/9781498712965-24.

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Taber, Douglass F. "New Methods for C-C Bond Construction." In Organic Synthesis. Oxford University Press, 2013. http://dx.doi.org/10.1093/oso/9780199965724.003.0023.

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Luigino Troisi of the University of Salento found (Tetrahedron Lett. 2010, 51, 371) that a variety of primary and secondary amines could be coupled with a benzylic halide 1 under carbonylating conditions. Ilhyong Ryu of Osaka Prefecture University showed (Organic Lett. 2010, 12, 1548) that under reducing conditions, an iodide 3 coupled with CO to give the primary alcohol. Felicia A. Etzkorn of Virginia Tech observed (Organic Lett. 2010, 12, 696) that under Hg hydrolysis conditions, the orthothioester derived from 5 coupled with 6 to give 7. Yasuharu Yoshimi of the University of Fukui and Minoru Hatanaka of Iwate Medical University devised (Tetrahedron Lett. 2010, 51, 2332) conditions for the decarboxylative addition of the acid 8 to 9 to give 10. Yong-Min Liang and Xiaojun Yao of Lanzhou University and Chao-Jun Li of McGill University described (J. Org. Chem. 2010, 75, 783) a related procedure with α-amino acids. Yasutaka Ishii of Kansai University established (J. Am. Chem. Soc. 2010, 132, 2536) that t -butyl acetate 12 was an effective partner for the Ir-mediated oxidation-coupling-reduction of an alcohol 11. He used (J. Org. Chem. 2010, 75, 1803) a similar protocol to condense acetone with the diol 14, to give the long-chain diketone 16. The formation of allylic Grignard reagents can be inefficient because the excess reactive halide tends to couple with the Grignard reagent as it forms. Brandon L. Ashfeld of the University of Notre Dame found (Tetrahedron Lett. 2010, 51, 2427) a simple solution to this problem: inclusion of a catalytic amount of the inexpensive Cp2 TiCl2 to mediate the addition of 18 to 17. Brian T. Connell of Texas A&M University demonstrated (J. Am. Chem. Soc. 2010, 132, 7826) that with Mn, 21 could be added to 20. The acetate 21 is thus an easily prepared homoenolate equivalent. Note that although 21 is an E/Z mixture, the product 22 is cleanly Z. Gérard Cahiez of the Université de Paris 13 reported (Synlett 2010, 299) a detailed study of the Cu-catalyzed coupling of 24 with 23. Without supporting ligands, slow addition (syringe pump, 1 h) of 24 to 23 assured clean formation of 25. Manual slow addition (dropping funnel, 15 min) was not effective.
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Taber, Douglass F. "Organocatalyzed C–C Ring Construction: The Mihovilovic Synthesis of Piperenol B." In Organic Synthesis. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780190646165.003.0072.

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M. Kevin Brown of Indiana University prepared (J. Am. Chem. Soc. 2015, 137, 3482) the cyclobutane 3 by the organocatalyzed addition of 2 to the alkene 1. Karl Anker Jørgensen of Aarhus University assembled (J. Am. Chem. Soc. 2015, 137, 1685) the complex cyclobutane 7 by the addition of 5 to the acceptor 4, followed by conden­sation with the phosphorane 6. Zhi Li of the National University of Singapore balanced (ACS Catal. 2015, 5, 51) three enzymes to effect enantioselective opening of the epoxide 8 followed by air oxidation to 9. Gang Zhao of the Shanghai Institute of Organic Chemistry and Zhong Li of the East China University of Science and Technology added (Org. Lett. 2015, 17, 688) 10 to 11 to give 12 in high ee. Akkattu T. Biju of the National Chemical Laboratory combined (Chem. Commun. 2015, 51, 9559) 13 with 14 to give the β-lactone 15. Paul Ha-Yeon Cheong of Oregon State University and Karl A. Scheidt of Northwestern University reported (Chem. Commun. 2015, 51, 2690) related results. Dieter Enders of RWTH Aachen University constructed (Chem. Eur. J. 2015, 21, 1004) the complex cyclopentane 20 by the controlled com­bination of 16, 17, and 18, followed by addition of the phosphorane 19. Derek R. Boyd and Paul J. Stevenson of Queen’s University Belfast showed (J. Org. Chem. 2015, 80, 3429) that the product from the microbial oxidation of 21 could be protected as the acetonide 22. Ignacio Carrera of the Universidad de la República described (Org. Lett. 2015, 17, 684) the related oxidation of benzyl azide (not illustrated). Manfred T. Reetz of the Max-Planck-Institut für Kohlenforschung and the Philipps-Universität Marburg found (Angew. Chem. Int. Ed. 2014, 53, 8659) that cytochrome P450 could oxidize the cyclohexane 23 to the cyclohexanol 24. F. Dean Toste of the University of California, Berkeley aminated (J. Am. Chem. Soc. 2015, 137, 3205) the ketone 25 with 26 to give 27. Benjamin List, also of the Max-Planck-Institut für Kohlenforschung, reported (Synlett 2015, 26, 1413) a parallel investigation. Philip Kraft of Givaudan Schweiz AG and Professor List added (Angew. Chem. Int. Ed. 2015, 54, 1960) 28 to 29 to give 30 in high ee.
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"toChristian th e is m . 151 And s o , ofcourse , w as P la to n is m . 152 The T im aeu shadtalkedofaFa th e r an d M aker oftheco sm o s. And tolaterwriters , Plato seem ed todistinguishthreeu lt imateorigins , principles , archai : God, M a tte r an d Form , w h ic h th eyalsolistedasthe By Whom, From W hat an dInV iew ofW hat; oras God, M a tte r an dthePattern ; orastheAc tiv e , theMa tte r and thePattern . O rth odoxChristian th e is m w as, ofcourse , toa rg uethatofthesethree , God a lo n e was absolutelyoriginal , an dthatMa tte r an d Form somehow to oktheirorigin from h im . 153 Even in Christ 's lifetime , Philo — a Jew nevercon ­ vertedto th e new church — w as bringingStoic an dPlatonice le men ts together in amonothe is t ic cosm ogony w h ic hsetastrikingprecedentforChristianwriters . CitingPlato , Philogaveas " th ereason why theun iv ersew as made ," that " th eFa th e r an d M aker isgood , and thatbe in g good He d id notg ru dge th ebestk in dofnaturetoma tt e r (o usia ) w h ic hofitselfhadno th in gexcellent , th oughitw as capab le ofb eco m in gallthings . " Philodoesnotderivematter from H a tc h , G * re ^ eTkhIidseaacsc . ou17n5t -7 o7f . Stoicco sm o lo gyisthatg iv e n by 152 th e o lo gyisTe he xcceolmlenptatibilityofP la to n is m w ith ChristianP la to n is m and ItsInflluyenbcroeug (B htoso to unt , in 19A2 . 4 ) E . . Taylor 's 153H a tc h , G reek Ideas . 180 -8 2 ." In Origins and Species, 624–823. Routledge, 2018. http://dx.doi.org/10.4324/9780429450198-21.

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Taber, Douglass F. "The Morken Synthesis of (+)-Discodermolide." In Organic Synthesis. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780190646165.003.0100.

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The anticancer properties of discodermolide 3 were exciting enough that Novartis undertook a commercial-scale total synthesis. While initial clinical trials were not suc­cessful, it is still a very promising lead structure. James P. Morken of Boston College developed (Angew. Chem. Int. Ed. 2014, 53, 9632) a practical approach, based on the Still–Gennari coupling of the phosphonate 1 with the aldehyde 2. The preparation both of 1 and of 2 showed to advantage the diene borylations that have been developed by the Morken group over the past several years. The alde­hyde 5 was prepared by enantioselective hydroformation of the protected acrolein 4. Borylation of pentadiene 6 followed by diastereoselective addition to 5 set, after oxi­dation, the three new stereogenic centers of 7. Ir-catalyzed hydroboration led to the primary alcohol, that was carried through aldehyde deprotection and oxidation to the ester 8. Oxidation of the alcohol to the acid 9 followed by activation with 10 and cou­pling with the anion 11 then completed the synthesis of 1. The preparation of the key Z-trisubstituted alkene chiron 16 again began with enantioselective hydroformylation of the allyl silyl ether 12 to 13. The addition of 14 proceeded with high diastereoselectivity. Nickel-catalyzed borylation of 15 was also highly diastereoselective, leading to an intermediate that was oxidized to the primary alcohol, then carried on the iodide 16. Pt-catalyzed enantioselective borylation of 6 followed by the addition of chloro­methyl lithium led, after oxidation, to the diol 17. Exposure of the derived bis tosyl­ate to potassium t-butoxide led to facile elimination of the homoallylic tosylate. The remaining tosyl protecting group was then removed reductively to give 18. The Roush reductive aldol protocol using the enolate derived from 19 was applied to the derived aldehyde, leading to 20, that was carried on to 21. Under carefully defined conditions, the E-enolate of 21 coupled efficiently with the allylic iodide 17 to give 2. Still–Gennari coupling with 1 to give 22 followed by selective reduction, deprotection, and lactonization then completed the synthesis of (+)-discodermolide 3.
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Taber, Douglass F. "Organic Functional Group Protection." In Organic Synthesis. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780190646165.003.0014.

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Sentaro Okamoto of Kanagawa University developed (Tetrahedron Lett. 2014, 55, 7039) an organocatalyst that mediated the selective acylation of 1 to give the pri­mary acetate 2. Philip A. Albiniak of Ball State University devised (Tetrahedron Lett. 2014, 55, 7133) a reagent 4 for the simple preparation of a t-butyl ether 5 from an alcohol 3. Attempted deprotection of 6 tended to divert to the dioxolane. Toshio Nishikawa of Nagoya University developed (Synlett 2014, 25, 2498) an oxidative protocol that gave clean conversion to the desired 7. Alan S. Goodman of Rutgers University found (Angew. Chem. Int. Ed. 2014, 53, 10160) an Ir catalyst that generated the phenol 9 from the aryl alkyl ether 8. In the course of a synthesis of Sch 725674, Kavirayani R. Prasad of the Indian Institute of Science, Bangalore deprotected (Org. Lett. 2014, 16, 4001) the dithi­ane 10 to yield the sensitive aldol product 11. Karl Anker Jørgensen of Aarhus University observed (Chem. Commun. 2014, 50, 15689) that the nitro isoxazole 12, having served to activate sequential Michael addition, was readily cleaved to the acid 13. Jiang Cheng of Changzhou University used (Chem. Commun. 2014, 50, 8412) CuCN to convert 14 to 15. Pradeep Kumar of CSIR-National Chemistry Laboratory effected (Tetrahedron Lett. 2014, 55, 7172) oxidative deallylation of 16, leading to 17. Hiroyuki Morimoto and Takashi Ohshima of Kyushu University found (Chem. Commun. 2014, 50, 12623) that NH₄I promoted the hydrazinolysis of the amide 18, giving 19 without racemization. Franco Ghelfi of the Università degli Studi di Modena e Reggio Emilia prepared (Eur. J. Org. Chem. 2014, 6734) 21 by desulfonylating 20 to 21 with H₂SO₄ in acetic acid. Hans Adolfsson of Stockholm University reduced (Org. Lett. 2014, 16, 680) the amide 22 to the enamine 23. The N-vinyl amine could be hydrolyzed, but it is also a versatile intermediate for other transformations. Automated peptide synthesis can be hindered by difficult sequences. Judit Tulla-Puche and Fernando Albericio of IRB Barcelona showed (Chem. Eur. J. 2014, 20, 15031) that the substituted benzyl group of 24 facilitated such syntheses, and that it could be readily removed to give 25 by exposure to NH₄I and trifluoroacetic acid.
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Taber, Douglass F. "Alkaloid Synthesis: Mearsine (Taylor), Cephalotaxine (Li), Cocaine (Shing), Quinine (Hatakeyama), Cleavamine (Bennasar), Strychnine(Vanderwal)." In Organic Synthesis. Oxford University Press, 2013. http://dx.doi.org/10.1093/oso/9780199965724.003.0060.

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Richard J. K. Taylor of the University of York employed (Tetrahedron Lett. 2011, 52, 2024) the Jørgensen protocol to add 2 to 1, to give the enantiomerically enriched cyclohexenone 3. Condensation of 3 with aqueous ammonia led directly to (-)-mearsine 4. Wei-Dong Z. Li of Nankai University found (Org. Lett. 2011, 13, 3538) that the intermediate from Dibal reduction of the lactone 5 underwent Nazarov cyclization, giving the α-hydroxy cyclopentenone 6. After acetylation, deprotection gave an amine that cyclized with high diastereocontrol, leading to (±)-cephalotaxine 7. Tony K. M. Shing of the Chinese University of Hong Kong cyclized (Org. Lett. 2011, 13, 2916) the aldehyde 8 by exposure to 9. The product 10 was carried on to (-)-cocaine 11, as well as several hydroxylated cocaine derivatives. Susumi Hatakeyama of Nagasaki University found (Tetrahedron Lett. 2011, 52, 923) that exposure of the simple prochiral aldehyde 12 to catalytic proline transformed it, after reduction, into the cyclized diol 13 in high ee. The diol 13 was readily carried on to quinine 14. M.-Lluïsa Bennasar of the University of Barcelona devised (Org. Lett. 2011, 13, 2042) Pd-catalyzed conditions for the cyclization of 15 that selectively delivered the unstable kinetic product 18. Selective hydrogenation of the more reactive bridgehead alkene then led to cleavamine 17. The alkene 16 is also prochiral, so it is possible that a catalyst could be found that would deliver 17 in high ee. The synthesis of the heptacyclic alkaloid strychnine 23 would, in the past, have been a major undertaking. Christopher D. Vanderwal of the University of California, Irvine, prepared (Chem. Sci. 2011, 2, 649) 23 in just six linear steps. The dienyl aldehyde 18 was available in two steps from tryptophyl bromide. Exposure to t -BuOK cyclized 18 to 19. N-deallylation followed by alkylation with 20 provided 21, setting the stage for a truly spectacular Brook rearrangement/conjugate addition, to give the Wieland-Gumlich aldehyde 22. The known condensation with malonic acid completed the preparation of 23.
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Taber, Douglass F. "New Methods for Carbocyclic Construction: The Kim Synthesis of Pentalenene." In Organic Synthesis. Oxford University Press, 2013. http://dx.doi.org/10.1093/oso/9780199965724.003.0080.

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Daesung Lee of the University of Illinois, Chicago, taking advantage of the facile insertion of an alkylidene carbene into a C-Si bond, established (J. Am. Chem. Soc. 2010, 132, 6640) a general method for the conversion of an α-silyl ketone 1 into the silyl cyclopropene 3. Christopher D. Bray of Queen Mary University showed (J. Org. Chem. 2010, 75, 4652) that the sulfonyl phosphonate 5 converted the enantiomerically pure epoxide 4 into the cyclopropane 6. Paul Margaretha of the University of Hamburg observed (Organic Lett. 2010, 12, 728) smooth photochemical combination of 7 and 8 to give 9 with high diastereocontrol. Tõnis Kanger of the Tallinn University of Technology devised (Organic Lett. 2010, 12, 2230) the three-component coupling of 10, 11, and diethyl amine to give, after reduction, the highly substituted cyclobutane 12. Min Shi of the Shanghai Institute of Organic Chemistry uncovered (J. Org. Chem. 2010, 75, 902) an interesting new thermal rearrangement: the conversion of 13 to 14. José G. Ávila-Zárraga of the Universidad Nacional Autónoma de México applied (Tetrahedron Lett. 2010, 51, 2232) Pd catalysis to the cyclization of the epoxy nitrile 15, redirecting the reaction from the expected cyclobutane to the cyclopentanol 16. Ullrich Jahn of the Academy of Sciences of the Czech Republic effected (J. Org. Chem. 2010, 75, 4480) the oxidative radical cyclization of 17 to 18. Initial deprotonation of the substrate with t -BuMgCl switched the product to the trans diastereomer. Jonathan W. Burton of the University of Oxford employed (Organic Lett. 2010, 12, 2738) a related oxidative cyclization for the diastereoselective conversion of 19 to 20. E. J. Corey of Harvard University reported (Organic Lett. 2010, 12, 300) a new ligand for the enantioselective Ni-mediated reduction of 21 to 22. Shu-Li You, also of the Shanghai Institute of Organic Chemistry, established (J. Am. Chem. Soc. 2010, 132, 4056) that the alcohol 23, readily prepared by oxidation of p -cresol, could be cyclized to the crystalline 25 in high ee.
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Taber, Douglass F. "New Methods for Reduction and for Oxidation." In Organic Synthesis. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780190646165.003.0009.

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Clemens Krempner of Texas Tech University devised (Chem. Eur. J. 2014, 20, 14959) a very active Al catalyst for the Meerwein-Ponndorf-Verley reduction of a ketone 1 to the alcohol 2. Louis Fensterbank and Cyril Ollivier of UMPC and Jean-Philippe Goddard of the Université de Haute-Alsace showed (Adv. Synth. Catal. 2014, 356, 2756) that visible light could mediate the reduction of the O-thiocarbamate 3 to 4. Soon Hyeok Hong of Seoul National University used (Org. Lett. 2014, 16, 4404) hydrogen from the diol 6 to reduce the nitrile 5, leading directly to the protected amine 7. Alex Adronov of McMaster University (J. Org. Chem. 2014, 79, 7728) and Thibault Cantat of Gif- sur-Yvette (Chem. Commun. 2014, 50, 9349) observed that an aryl amide 8 could be reduced to the amine 9 under conditions that left alkyl amides unchanged. Paul J. Chirik of Princeton University developed (J. Am. Chem. Soc. 2014, 136, 13178) a Co catalyst for the alcohol- directed reduction of a proximal alkene, converting 10 selectively to 11. Yoichiro Kuninobu and Motomu Kanai of the University of Tokyo used (Synlett 2014, 25, 1869) stoichiometric Mo(CO)₆ to desulfurize 12 to 13. Utpal Bora of Tezpur University oxidized (Tetrahedron Lett. 2014, 55, 5029) the alcohol 14 to the aldehyde 15 with t-butyl hydroperoxide, using the inexpensive and reusable VOSO₄ as the catalyst. The oxidation of an alcohol to the acid is often car­ried out in two steps, alcohol to aldehyde and aldehyde to carboxylic acid. Kenneth B. Wagener of the University of Florida developed (Tetrahedron Lett. 2014, 55, 4452) a protocol for the direct oxidation of an alcohol 16 to the acid 17. Prodeep Phukan of Gauhati University devised (Tetrahedron Lett. 2014, 55, 5358) a catalyst-free procedure for the oxidation of a primary alcohol 18 to the ester 19. The aldehyde cor­responding to 18 (not illustrated) was also efficiently oxidized to 19. Katsuhiko Moriyama and Hideo Togo of Chiba University effected (Org. Lett. 2014, 16, 3812) the oxidative debenzylation of 20 to the ketone 21.
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Conference papers on the topic "T (8;21)"

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Powell, Charles A., Shanu Modi, Hiroji Iwata, Shunji Takahashi, Egbert F. Smit, Salvatore Siena, Dwan-Ying Chang, et al. "Abstract CT167: Pooled analysis of drug-related interstitial lung disease (ILD) in 8 single-arm trastuzumab deruxtecan (T-DXd) studies." In Proceedings: AACR Annual Meeting 2021; April 10-15, 2021 and May 17-21, 2021; Philadelphia, PA. American Association for Cancer Research, 2021. http://dx.doi.org/10.1158/1538-7445.am2021-ct167.

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Eikawa, Shingo, Yoshihiro Ohue, Kenta Kitaoka, Toshiki Aji, Akiko Uenaka, Mikio Oka, and Eiichi Nakayama. "Abstract 1915: Enrichment of Tregs in migrated T-cells to IL-6- and IL-8-expressing tumors through induction of CXCR1 by IL-6." In Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1538-7445.am10-1915.

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Mombaerta, P., V. Ballegeer, P. Declerck, F. A. Van Assche, and D. Collen. "FIBRINOLYTIC RESPONSE TO VENOUS OCCLUSION, AND FIBRIN FRAGMENT D-DIMER AND FIBRONECTIN LEVELS IN NORMAL AND COMPLICATED PREGNANCY." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643143.

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The fibrinolytic response to venous occlusion was assessed in pregnant women with measurements of total and free t-PA, using specific ELISAs based on monoclonal antibodies.Total t-PA levels increased after venous occlusion with 11±8 ng/ml (mean ± SD) in healthy fertile non-pregnant women (n=6), with 0.8 ± 1.3 ng/ml in 2nd trim. (n=5) and with 3.8 ± 3.9 ng/ml in 3rd trim. (n=4) healthy pregnant women. The increase in free t-PA was 12 ± 11; 1.2 ± 0.9 and 0 ng/ml respectively. The difference in post- and pre-occlusion levels in 3rd trim, pregnant women with insulin dependent diabetes mellitus IDDM (n=4) was 3.2 ± 4.2 ng/ml, with intrauterine growth retardation (IUGR) (n=4) 2.6 ± 3.0 ng/ml and with preeclampsia (n=5) 3.2 ± 3.5 ng/ml for total t-PA and 0, 0 and 0 ng/ml for free t-PA.Fibrin fragment D-dimer levels in plasma measured with a specific ELISA were 130 ± 36 ng/ml in healthy fertile non-pregnant women (n=8). A significant increase was found in 4 out of 5 1st trim., 25 out of 25 2nd trim, and 21 out of 22 3rd trim, normal pregnant women. In these groups, plasma levels were 340 ± 160, 400 ± 170 and 440 ± 220 ng/ml respectively.Fibronectin levels, measured with a Laurell electroimmunoassay and expressed as percentage of pooled human plasma (=330 yg/ml) were 83 ± 26% in 2nd trim, patients (n=24) and 102 ± 35% in 3rd trim, patients (n=17). Normal fibronectin levels were found in 4 patients with IDDM and in 6 with IUGR, whereas in 6 out of 8 preeclamptic patients significantly increased levels were observed.These results confirm, with the use of a newly developed free t-PA assay, that the fibrinolytic response to venous occlusion is completely inhibited in the 3rd trimester of pregnancy. A reduced release of t-PA from the vessel wall during venous occlusion and/or an increased inhibition of released t-PA were observed. No difference was found in the fibrinolytic response between normal and complicated pregnancy. D-dimer levels are significantly elevated during pregnancy. Finally, the usefulness of fibronectin for the diagnosis of preeclampsia is confirmed.
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4

Anakapalli, Manoj, P. Raju Mantena, Ahmed Al-Ostaz, and S. Jimmy Hwang. "Impulse-Frequency Response and EIS Based NDE for Characterizing Bond Integrity of Adhesive Joints Subjected to Environmental Degradation." In ASME 2005 International Mechanical Engineering Congress and Exposition. ASMEDC, 2005. http://dx.doi.org/10.1115/imece2005-79421.

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Single-Lap Joint (SLJ) and three-point end-notched flexure (ENF) joint configurations were used to bond 1” × 1/8″ (25.4mm × 3.175mm) aluminum 2024 T-4 adherends using a range of 3M™ high performance pressure sensitive adhesives (Adhesives 69, 73 and 85) and VHB™ acrylic foam tapes (Foam 41, 50, 52). Batches of bonded specimens were subjected to two types of aggressive environments simulating extreme service conditions: freeze-thaw cycling from 10°F to 50°F at 6 cycles per day (ASTM C666 Procedure A) for 21 days with samples immersed in water; heat-cool cycling (with 90% of maximum recommended temperature by the manufacturer of both acrylic foam and adhesive transfer tapes attained at 70% relative humidity) and 3 cycles per day for 21 days. Electrochemical Impedance Spectroscopy (EIS) and Fast Fourier Transform (FFT) based impulse frequency response vibration Non-Destructive Evaluation (NDE) techniques were used to monitor overall bond integrity.
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5

Anakapalli, Manoj, P. Raju Mantena, Ahmed Al-Ostaz, and S. Jimmy Hwang. "Quasi-Static Lap Shear and Dynamic Impact of High Performance VHB™ Acrylic Foam and Adhesive Transfer Tape Bonded Aluminum Joints Subjected to Environmental Degradation." In ASME 2005 International Mechanical Engineering Congress and Exposition. ASMEDC, 2005. http://dx.doi.org/10.1115/imece2005-79425.

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A range of 3M™ VHB™ acrylic foam tapes and high performance adhesive transfer tapes were used to bond 1” × 1/8″ (25.4 mm × 3.175 mm) aluminum 2024 T-4 adherends in single-lap joint (SLJ) and three-point end-notched flexure (ENF) configurations. Three types of 0.045” thick double-coated acrylic foam tapes: Foam 41, 50 and 52 (firm, soft and softer), and three types of adhesive transfer tapes: Adhesives 69, 73 and 85 (0.005”, 0.01” and 0.005” thick, respectively) were used for this study. The samples were subjected to two types of aggressive environments simulating extreme service conditions: freeze-thaw cycling from 10°F to 50°F at 6 cycles per day (ASTM C666 Procedure A) for 21 days with samples immersed in water; heat-cool cycling (with 90% of maximum recommended temperature by the manufacturer of both acrylic foam and adhesive transfer tapes attained at 70% relative humidity) and 3 cycles per day for 21 days. Initially the impulse-frequency response vibration and electrochemical impedance spectroscopy (EIS) techniques were used for monitoring bond quality nondestructively and selecting the best out of 250 fabricated samples. After obtaining baseline data, the specimens were subjected to quasi-static lap-shear and dynamic impact loading to compare their lap-shear failure loads and shear energy along with the impact load and energy absorbed.
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6

Izumi, K., M. Noguchi, E. Iwasaki, K. Deguchi, and S. Shirakawa. "VASCULAR DAMAGE IN PATIENTS ON CHRONIC HEMODIALYSIS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643346.

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Calcification in the abdominal artery and endothelial cell function of the peripheral veins were studied in the patients recieving maintenance hemodialysis for the chronic renal failure.The grade of calcification was expressed by the aortic calcification index (ACI) calculation from the abdominal CT scan films. The endothelial cell function was estimated from the release capasity for tissue plasminogen activator (t-PA) and von Willebrand factor (vWF), and the fibrinolytic capacity (by ELT and fibrin plate lysis area) during 10-min venous occlusion (VO) of the cubital vein. The dialysed patients were divided into 4 groups according to the duration of hemodialysis : group A ; under 1 year (n=7), group B ; 1-4 years (n=14), group C ; 4-7 years (n=15) and group D ; 7-10 years (n=8).The level (X + SD) of vWF : Ag, vWF act. (RCoF) and t-PA in patients before VO were 439 ± 255(%),171 ± 42(%), 4.2 ± 0.6(ng/ml) in group A, 292 ± 157, 151 ± 35, 4.1 ± 1.2 in group B, 174 ± 114, 133 ± 47, 3.7 ± 0.8 in group C and 130 + 27, 66 ± 21, 3.1 ± 0.7 in group D, respectively. With the increase in the duration of hemodialysis, the release capacity for vWF and t-PA, and the fibrinolytic capacity during VO decreased regardless of the aggravation of fibrinolytic activity before VO, When the activity was estimated by ELT, Cl-inactivator resistant fibrinolytic activity and fibrin lysis area. These findings are thought to reflect the exhaustion of endotherial cells. In elder patients (60-80 years old), the release capacity for vWF and t-PA during VO decreased with the increase in the ACI level.It is conclude that the patients on chronic hemodialysis have a greater incidence of calcification of abdominal artery and lower function of endothelial cells in the cubital vein than non-dialysed control.
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7

Saisorn, Sira, Somchai Wongwises, Pakorn Wongpromma, Phakkhanan Benjawun, and Adirek Suriyawong. "Two-Phase Heat Transfer Behaviors of R-134a Refrigerant and Air-Water Mixture in a 1 mm Internal Diameter Tube." In ASME 2016 Heat Transfer Summer Conference collocated with the ASME 2016 Fluids Engineering Division Summer Meeting and the ASME 2016 14th International Conference on Nanochannels, Microchannels, and Minichannels. American Society of Mechanical Engineers, 2016. http://dx.doi.org/10.1115/ht2016-1004.

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Flow boiling of R-134a refrigerant was experimentally conducted in a test section which is a stainless steel tube having internal diameter of 1 mm. The DC power supply was connected to the test section to provide constant surface heat flux conditions. Flow pattern and heat transfer data were obtained for a mass flux range of 252–820 kg/m2s, a heat flux range of 1–21 kW/m2 and a saturation pressure of 8 bar. The flow visualization results showed four different flow patterns including slug flow, throat-annular flow, churn flow, and annular flow. The flow boiling heat transfer behaviors were also compared with those based on non-boiling two-phase air-water flow in the same test section under constant surface heat flux conditions. For non-boiling two-phase flow experiment, an air-water T-shaped mixer was served to introduce fluids smoothly along the test section. The results indicated that based on the same gas and liquid Reynolds numbers, flow boiling tends to have Nusselt number higher than that for non-boiling gas-liquid flow.
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8

Boisseau, M. R., J. Bonnet, G. Freyburger, P. Desbordes, L. Brottier, J. M. Orgogozo, and H. Bricaud. "HEMOSTASIS AND HEMORHEOLOGY AFTER ISCHEMIC STROKE IN PATIENTS WITHOUT CARDIOPATHY AND OTHER LOCALISATION OF ATHEROSCLEROSIS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644210.

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Hemorheological parameters (whole blood filtration, whole blood viscosity, plasma viscosity and erythrocyte deformability by ektacytometry) and fibrinolysis parameters (Euglobulin Lysis Time ELT, t-PA activity, and Plasminogen ActivatorInhibitor -PAI- before and after Venous Occlusion Test -VOT-) were measured in 20 stroke patients. All these patients had a crerebrovascular accident (CVA) localised to the carotid arterial tree. They has no signs of heart disease and were without risk factors for atherosclerosis (high blood pressure, diabetes) ; they were investigated in the week following the CVA. They were divided into 4 groups : 1/ transcient ischemic accident, 2,3,4/ size of infarct classified from results of C. T. Scan carried out 2 or 3 days after the stroke (2/small +, 3/moderate ++, 4/large +++).For the hemorheological parameters we noted only a slight increase in whole blood filtration (27±8“ vs 21±2”, p<0,05).The ELT was however significantly increased in these patients (258 ±57 min. vs 133 ±33,p<0,001)suggesting impairement of fibrinolysis. The following points were noteworthy : the ELT return to normal after to VOT,there was a relationship between stroke severity and the PAI levels and the viscosity at low shear stress. These two parameters were dramatically impaired in the most severely affected patients. Transcient ischemic accidents had comparable features to the CVA of moderate size.The extend of the disorders of the hemorheological disorders and the abnormalities in fibrinolysis seemed to be related to the severity of the involvement in patients with ischemic stroke with no evidence of heart disease or atherosclerosis in other systems.
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9

Murayama, H., and N. U. Bang. "INCORPORATION OF PLASMINOGEN ACTIVATOR INHIBITOR INTO FIBRIN, AN ALTERNATIVE REGULATORY PATHWAY OF FIBRINOLYSIS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644442.

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A plasminogen activator inhibitor (PAI-1) Mj, 50 kd is normally found in plasma at low concentrations. Plasma levels increase sharply upon stimulation of endothelial cells with endotoxin or monokines and activated platelets secrete significant quantities of PAI-1. It is possible that high levels of PAI-1 may be achieved at the local sites of intravascular thrombi. Semipurified PAI-1 was therefore prepared from human platelets to study its affinity for fibrin (F). Approximately 50% PAI-1 adsorbed to F monomer immobilized on sepharose and desorbed under conditions of acidic pH and high ionic strength suggesting hydrogen bonding as the mode of interaction. Wells of 96-well microtiter plates were each coated with 50 yg [125I] plasminogen (P)-free fibrinogen and clotted with thrombin in the presence and absence of different concentrations of PAI-1. After extensive washing of the wells, they were incubated with 5 mU of tissue plasminogen activator (t-PA) and 5 mU of P for 6 h. Appropriate calibration curves utilizing different concentrations of t-PA and different concentrations of PAI-1 added to the supernatant rather than to F established that 8-15% of 21-166 mU PAI-1 incorporated into crosslinked (XL) F or noncrosslinked (NXL) F. Incorporated PAI strikingly inhibited fibrinolysis (FL). Percent inhibition of FL of XL or NXLF (Mean±S.D., N=5) plotted in the presence of 166, 83, 42 and 21 mU of PAI were: 83±3.3, 59.5±1.8, 29.7±5.2 and 15.2±6.14 for XLF and 78±5.3, 31±8.1, 14.5±10.5 and 0 Tor NXL F. As demonstrated by radioautography on SDS PAGE PAI-1 incorporated into F readily formed complexes with [125I] urokinase (u-PA). In these experiments, no evidence for crosslinking of PAI-1 into F has been obtained to date. In experiments utilizing agarose immobilized proteins, it was evident that not only F but also fibrinogen binds PAI-1; PAI-1 associated with F as well as fibrinogen is capable of forming complexes with [1251] u-PA.In contrast, fibronectin, collagen, gelatin and albumin did not bind PAI-1. Thus, PAI-1 in analogy with alpha-2 plasmin inhibitor may modulate physiological fibrinolysis through incorporation into fibrin.
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10

Paixão, Mateus Silva, Arilson Jeans Monteiro Dos Santos, Paulo Weslem Portal Gomes, and Alcindo Da Silva Martins Junior. "PERCEPÇÃO AMBIENTAL: GERENCIAMENTO DOS RESÍDUOS SÓLIDOS NO MUNICÍPIO DE SALVATERRA, PARÁ." In I Congresso Nacional On-line de Conservação e Educação Ambiental. Revista Multidisciplinar de Educação e Meio Ambiente, 2021. http://dx.doi.org/10.51189/rema/1807.

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Introdução: A acelerada urbanização tem estimulado novos hábitos, um deles é a alta produção de Resíduos Sólidos (RS), que, uma vez descartados em lixões, podem causar graves problemas ambientais. Objetivo: Neste sentido, este estudo teve como objetivo analisar a percepção ambiental dos moradores do Bairro Centro e Ramal do Juca a respeito do gerenciamento dos RS do município de Salvaterra, Ilha de Marajó, Pará. Materiais e métodos: Esta pesquisa foi aprovada no comitê de ética da Universidade do Estado do Pará, com número de aprovação: 3.915.797. As entrevistas foram realizadas em dezembro/2019, utilizou-se um formulário dividido em dois blocos, o primeiro bloco sobre o perfil socioeconômico e o segundo sobre a percepção ambiental com afirmações na escala de Likert de cinco pontos. A intensidade de percepção foi classificada como: “baixa”, 1–3; “moderada”, 4–6; e “alta”, 7–10; e foram analisadas utilizando o teste t de Student. Resultados: Foram entrevistados 135 moradores (54% mulheres e 46% homens), distribuídos nas faixas etárias de menores de 20 anos (13,3%), 21 a 40 anos (41,5%), 41 a 60 anos (35,5%) e acima de 60 anos (9,7%). Observou-se que 0,7% dos moradores não possuem escolaridade, 28% possui ensino fundamental incompleto, 9% fundamental completo, 16,3% ensino médio incompleto, 31% ensino médio completo, 11% ensino superior incompleto e apenas 4% superior completo. A maioria dos entrevistados vivem com renda mensal inferior a um salário mínimo, sendo 37,7% com até R$500, 28, 8% até R$ 1000 e 33,5% possuem renda acima de R$1000. Em relação a percepção dos moradores, no Bairro Centro (intensidade de percepção: 7,94) quanto no Ramal do Juca (7,36), foi observada média de percepção alta, com diferença significativa nas duas localidades (p<0,05). Esses resultados evidenciaram que, mesmo em localidades distintas socioeconomicamente, os moradores apresentam conhecimento sobre o gerenciamento de RS em Salvaterra. Conclusão: Portanto, faz-se necessário a criação de políticas públicas, no sentido de difundir informação que favoreçam uma postura proativa dos residentes no processo de gerenciamento dos RS, podendo melhorar o serviço de gerenciamento do RS.
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