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Journal articles on the topic "T Advisor"
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Walti, Carla S., Joyce Maalouf, Jim Boonyaratanakornkit, et al. "196. Antibodies to Vaccine-preventable Infections After CAR-T Cell Immunotherapy for B Cell Malignancies." Open Forum Infectious Diseases 7, Supplement_1 (2020): S226—S227. http://dx.doi.org/10.1093/ofid/ofaa439.506.
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Abstract Background Chimeric antigen receptor-modified T (CAR-T) cell immunotherapy for B cell hematologic malignancies results in prolonged B cell depletion. Little is known about the effects of CAR-T cell therapy on pre-existing pathogen-specific humoral immunity. Methods We conducted a prospective, cross-sectional study of children and adults treated with CD19- or BCMA-CAR-T cell therapy. Eligible patients were ≥ 6 months post-CAR-T cell infusion and in remission without subsequent chemoimmunotherapy. We measured total immunoglobulin G (IgG), pathogen-specific IgG levels for 12 vaccine-preventable infections, and B cell subsets from blood. Seroprotective antibody titers were based on standard thresholds. We described the proportion of patients with seroprotective titers and tested for associations between clinical factors and seroprotection using generalized estimating equations. Results We enrolled 65 patients who received CD19- (n=54) or BCMA- (n=11) CAR-T cell therapy. Seven patients were < 18 years old. Samples were collected a median of 20 months (range, 7–68) after CAR T cell infusion. Seroprotection to vaccine-preventable pathogens was generally comparable to the U.S. population (Fig 1) even though blood CD19+ B cell counts were low (< 20 cells/mm3) in 60% of patients. Among 30 patients without IgG replacement in the prior 16 weeks (4 half-lives of IgG), 27 (90%) had hypogammaglobulinemia. Despite this, these individuals had seroprotection to a median of 67% (IQR, 59%-73%) of tested pathogens (Fig 2A). The proportion of patients with seroprotection was lowest for mumps, hepatitis A and B, H. influenzae type B (Hib), S. pneumoniae, and B. pertussis. Patients receiving BCMA-CAR-T cells had seroprotection to fewer pathogens than those receiving CD19-CAR-T cells (Fig 2B), but the difference did not reach statistical significance (Fig 3). There were no significant differences by other variables. Figure 1. Proportion of CAR-T cell recipients with seroprotection to vaccine-preventable infections compared to the U.S. population, stratified by receipt of IgG replacement in the previous 16 weeks. Figure 2 A-B. Percentage of pathogens with seroprotective antibody titers among patients without IgG replacement in the previous 16 weeks. Figure 3. Association of clinical factors with seroprotection to vaccine-preventable infections among patients without IgG replacement in the previous 16 weeks (n=30) Conclusion Seroprotection for vaccine-preventable infections after CD19-CAR-T cell therapy was comparable to the general population. BCMA-CAR-T cell recipients may benefit most from replacement IgG. Vaccinations after CAR-T cell therapy should be considered and prioritized for S. pneumoniae, Hib, hepatitis viruses, and B. pertussis. Disclosures Justin J. Taylor, PhD, Vir Biotechnology (Grant/Research Support) Damian J. Green, MD, Cellectar Biosciences (Grant/Research Support)GSK (Advisor or Review Panel member)Juno Therapeutics (Grant/Research Support, Advisor or Review Panel member, Other Financial or Material Support, Royalities)Seattle Genetics (Grant/Research Support, Advisor or Review Panel member) Michael Boeckh, MD PhD, AlloVir (Consultant)EvrysBio (Advisor or Review Panel member, Other Financial or Material Support, share options)Gilead (Consultant, Grant/Research Support)GSK (Consultant)Helocyte (Advisor or Review Panel member, Shareholder)Lophius (Grant/Research Support)Merck (Consultant, Grant/Research Support)SymBio (Consultant)VirBio (Consultant, Grant/Research Support) David G. Maloney, MD, PhD, A2 Biotherapeutics (Consultant, Other Financial or Material Support, Stock Options)Bioline Rx (Consultant)Celgene (Consultant, Grant/Research Support)Gilead (Consultant)Juno Therapeutics (Consultant, Research Grant or Support, Other Financial or Material Support, four pending patents, not issued, licensed, no royalities, no licensees)Kite Pharma (Consultant, Grant/Research Support)Novartis (Consultant)Pharmacyclics (Consultant) Cameron J. Turtle, MBBS, PhD, Allogene (Other Financial or Material Support, Ad hoc advisory board (last 12 months))ArsenalBio (Advisor or Review Panel member, Other Financial or Material Support, Stock/options)AstraZeneca (Grant/Research Support, Other Financial or Material Support, Ad hoc advisory board (last 12 months))Caribou Biosciences (Advisor or Review Panel member, Other Financial or Material Support, Stock/options)Century Therapeutics (Advisor or Review Panel member)Eureka Therapeutics (Advisor or Review Panel member, Other Financial or Material Support, Stock/options)Juno Therapeutics (Grant/Research Support, Other Financial or Material Support, Patent: Licensed to Juno Therapeutics)Myeloid Therapeutics (Advisor or Review Panel member, Other Financial or Material Support, Stock/options)Nektar Therapeutics (Grant/Research Support, Other Financial or Material Support, Ad hoc advisory board (last 12 months))PACT Pharma (Other Financial or Material Support, Ad hoc advisory board (last 12 months))Precision Biosciences (Advisor or Review Panel member, Other Financial or Material Support, Stock/options)TCR2 Therapeutics (Grant/Research Support)T-CURX (Advisor or Review Panel member) Joshua A. Hill, MD, Allogene (Consultant)Allovir (Consultant)Gilead (Consultant)Karius (Grant/Research Support, Scientific Research Study Investigator)Takeda (Grant/Research Support, Scientific Research Study Investigator)
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Mokhtari, Sepideh, Justin M. Asquith, Christina A. Bachmeier, et al. "The Use of Intravenous Immunoglobulin (IVIG) during Severe Neurotoxicity Among the Recipients of Chimeric Antigen Receptor T-Cell (CAR-T) Therapy." Blood 134, Supplement_1 (2019): 5627. http://dx.doi.org/10.1182/blood-2019-122343.
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INTRODUCTION: Severe neurotoxicity occurs in ~30% of Diffuse Large B Cell Lymphoma (DLBCL) patients treated with CAR-T cell therapy. The current treatment for severe neurotoxicity is glucocorticoids +/- tocilizumab (an IL-6 antagonist) depending on concurrent cytokine release syndrome. Even with these treatments, neurotoxicity can have a complicated course. It is therefore essential to find the optimal treatment to reverse neurotoxicity timely. METHOD:This is a retrospective cohort study of neurologic and oncologic outcomes among patients with grade ≥ 3 neurotoxicity treated with glucocorticoids and IVIG compared to glucocorticoids only. Severe neurotoxicity was defined as grade 3 and graded by CRES/CARTOX score. Time to resolution of severe neurotoxicity (TTR) was defined as improvement of severe neurotoxicity to grade ≤ 2. RESULTS: We identified a total of 20 patients who received CAR-T therapy and developed severe neurotoxicity. Ten patients received glucocorticoids and IVIG (group A) and ten patients received glucocorticoids alone (group B). The median age was 62 (range: 52-74) for group A vs 64 years (range: 48-75) for group B. Both groups had similar ECOG performance status (p=0.17), IPI scores (p=0.34), and onset of severe neurotoxicity (median=6 days in both groups). Median TTR was 3 days (range, 1-7) for group A and 4.5 days (range, 2-22) for group B. There was no significant difference in TTR of severe neurotoxicity among both groups (Log-rank p=0.18, Figure). The median time to administration of IVIG after initiation of glucocorticoids was 2 days (range, 0.5-8). The median TTR following initiation of IVIG was 0.5 day (0.5-4). The objective response rate at 30 days was 80% in both groups. None of the patients who received IVIG developed thromboembolism, renal failure, autoimmune hemolytic anemia or acute lung injury. CONCLUSIONS: Although the use of IVIG during severe neurotoxicity after CAR-T therapy appeared to be safe, this pilot retrospective analysis demonstrated no significant difference in resolution of severe neurotoxicity with addition of IVIG to glucocorticoids. Further controlled studies limiting selection bias inherent in this retrospective analysis will help to determine the efficacy of IVIG in severe neurotoxicity in the context of CAR-T cell therapy. Disclosures Mokhtari: KITE PHARMA: Other: Clinical Advisor; NOVARTIS: Other: Clinical Advisor. Bachmeier:Kite/Gilead: Speakers Bureau. Jain:Kite/Gilead: Consultancy. Forsyth:Department of Defense: Research Funding; Pfizer: Research Funding; State of Florida Bankhead Coley: Research Funding; Moffitt Center of Excellence Celgene Project: Research Funding; Florida Academic Cancer Center Alliance: Research Funding; NIH/NCI 1R21 Grant: Research Funding; NIT DT Study Section Grant Review: Membership on an entity's Board of Directors or advisory committees; AbbVie Inc: Consultancy, Membership on an entity's Board of Directors or advisory committees; Ziopharm: Consultancy, Membership on an entity's Board of Directors or advisory committees; Tocagen: Consultancy, Membership on an entity's Board of Directors or advisory committees; BTG: Consultancy, Membership on an entity's Board of Directors or advisory committees; Inovio: Consultancy, Membership on an entity's Board of Directors or advisory committees; Novocure: Consultancy, Membership on an entity's Board of Directors or advisory committees. Locke:Novartis: Other: Scientific Advisor; Cellular BioMedicine Group Inc.: Consultancy; Kite: Other: Scientific Advisor. Lazaryan:Kadmon: Consultancy.
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Kambhampati, Swetha, Bita Fakhri, Ying Sheng, et al. "Infectious Complications of BCMA-Targeted and CD19-Targeted Chimeric Antigen Receptor T-Cell Immunotherapy." Blood 136, Supplement 1 (2020): 4–5. http://dx.doi.org/10.1182/blood-2020-138940.
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Background: Chimeric antigen receptor T-cell (CAR T) immunotherapy is an evolving treatment for relapsed/ refractory non-Hodgkin lymphoma (NHL) and multiple myeloma (MM). There is a growing need to elucidate the infectious complications of BCMA- and CD19-directed CAR T therapy. We performed a single-center retrospective analysis of infection outcomes up to 1-year post BCMA and CD19-directed CAR T treatment. Methods: All patients treated at our institution with a BCMA-directed CAR T therapy for MM or with a CD19-directed CAR T for NHL from 2018-2020 were analyzed for risk factors for infection and infectious complications. Bacterial, viral and fungal infections were recorded if there was a microbiologic or histopathologic diagnosis or if clinical suspicion for infection required empiric treatment. Infection severity was classified as mild, moderate, severe, life-threatening, or fatal as previously described (Young et al. 2016, van Burnik et al. 2007). Infections were identified from the day of the first CAR T-cell infusion up to 1 year after infusion. Observation of infections was terminated at the time of disease progression, initiation of next therapy, or death, whichever occurred first. Fisher's exact test and Wilcoxon rank-sum test were used to compare between cohorts. Poisson mixed effects model with a subject-specific random intercept and an offset to account for the duration at risk was used to identify risk factors for infections. Results: Of the 104 subjects in this study, 55 patients (53%) had MM treated with BCMA CAR T and 49 patients (47%) had NHL treated with CD19 CAR T. Median number of prior therapies was 6 (4 - 9) in the BCMA cohort and 3 (2-4) in the CD19 cohort (Table 1). Prior to starting lymphodepleting (LD) chemotherapy, most patients did not have IgG< 400, ALC< 200, or ANC< 500. Almost all the patients were on antibacterial (99%), antiviral (99%) and antifungal (92%) prophylaxis (ppx), with 18%, 90% and 9% of patients starting this before LD chemotherapy, respectively. Median follow-up time was 5.8 months (95% CI: 4.2-6.4). In total, there were 87 infection events (48 bacterial, 33 viral, and 6 fungal) observed in 56 patients (54%), with 47 infections in 29 (53%) patients in the BCMA CAR T cohort and 40 infections in 27 (55%) patients in the CD19 CAR T cohort (p =0.9). The BCMA cohort had 19 bacterial (40%) vs 29 bacterial (73%) in CD19 cohort (p=0.005), while BCMA cohort had 25 viral (53%) vs 8 viral (20%) in CD19 cohort (p=0.002). Fungal infection rates were comparable between BCMA and CD19 cohorts, 3 (6%) vs 3 (8%) respectively (p=1). Among the infections that occurred, 20 (23%) were high severity occurring in 16 patients (15%) of the overall cohort. Four high severity infections (5%) occurred in 3 patients (5%) in the BCMA cohort while 16 high severity infections (18%) occurred in 13 patients (27%) in the CD19 cohort (p < 0.001) (Figure 1). The BCMA cohort had higher rates of respiratory infections (68% vs 50%, p=0.1), while the CD19 cohort had higher rates of bloodstream infections (15% vs 2%, p=0.05) and gastrointestinal infections (10% vs 0%, p=0.04). The rates of grade (Gr) 3-4 neutropenia and IgG < 300 in both the cohorts at various time points post CAR T were comparable. At 9-12 months, Gr 3-4 neutropenia was 7% vs 8% (p=1) and IgG < 300 was 7% vs 33% (p=0.1) for the BCMA and CD19 cohorts respectively. Adjusting for time periods, risk factors for development of infections were use of steroids (incidence rate ratio [IRR] 1.6, 95% CI: 1.1-2.5, p=0.03) and post CAR T hypogammaglobulinemia (IgG < 600) (IRR =2.1, 95% CI: 1.2-3.9, p=0.02). Conclusions: This retrospective study is one of the largest studies to date comparing the post CAR T infections rates between BCMA and CD19 directed CAR T treated patients. While the incidence of infection, use of antimicrobial ppx, and rates of Gr 3-4 neutropenia and hypogammaglobulinemia were comparable between BCMA and CD19 CAR T cohorts, viral infections were more common post BCMA CAR T while bacterial infections were more frequent post CD19 CAR T. Use of steroids as well as post CAR T hypogammaglobulinemia are possible risk factors for development of infections. Further studies are needed to examine the infectious complications post-CAR T treatment, characterize the underlying risk factors, and to establish appropriate prophylactic approaches in patients undergoing CD19- and BCMA-directed CAR T therapy. Disclosures Fakhri: University of California San Francisco: Current Employment. Ai:Nurix Therapeutics: Membership on an entity's Board of Directors or advisory committees, Research Funding; ADC Therapeutics, Kymera: Membership on an entity's Board of Directors or advisory committees. Martin:Seattle Genetics: Research Funding; GSK: Consultancy; Sanofi: Research Funding; AMGEN: Research Funding; Janssen: Research Funding. Wolf:Adaptive: Consultancy, Membership on an entity's Board of Directors or advisory committees, Speakers Bureau. Shah:BMS, Janssen, Bluebird Bio, Sutro Biopharma, Teneobio, Poseida, Nektar: Research Funding; GSK, Amgen, Indapta Therapeutics, Sanofi, BMS, CareDx, Kite, Karyopharm: Consultancy. Andreadis:Genentech: Other: Spouse Employee (salary and stock); Novartis: Research Funding; Celgene/Juno: Research Funding; Amgen: Research Funding; Merck: Research Funding; Gilead/Kite: Other: Advisor; Jazz Pharmaceuticals: Other: Advisor; Astellas: Other: Advisor; Seattle Genetics: Other: Advisor; Karyopharm: Other: Advisor; Incyte: Other. Wong:GSK: Research Funding; Amgen: Consultancy; Sanofi: Membership on an entity's Board of Directors or advisory committees; Bristol Myers Squibb: Research Funding; Roche: Research Funding; Janssen: Research Funding; Fortis: Research Funding.
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Hosry, Jeff, Felipe Samaniego, Francesco Turturro, Minas P. Economides, and Harrys A. Torres. "Effect of Lenalidomide on Hepatitis C Viremia in Cancer Patients: A Case Series." Blood 128, no. 22 (2016): 5691. http://dx.doi.org/10.1182/blood.v128.22.5691.5691.
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Abstract Background: T cells play an important role in controlling hepatitis C virus (HCV) infection. Immunomodulatory drugs affecting T cells such as thalidomide and lenalidomide are used in the treatment of some hematologic cancers (mainly multiple myeloma). Lenalidomide is up to 1000 times more potent than thalidomide in stimulating T cell proliferation, interferon-γ and interleukin-2 production. HCV reactivation (increase of HCV-RNA by at least 1 log10IU/mL) with hepatitis flare after thalidomide therapy was recently reported (Mahale et al., Open Forum Infect Dis. 2015); however, the effect of lenalidomide on HCV-viremia has not been studied yet. Methods: HCV-infected cancer patients treated with lenalidomide at MD Anderson Cancer Center (11/2012-3/2016) were studied. HCV-RNA levels were measured before and after lenalidomide use. Since chronically infected patients have stable HCV-RNA levels that only varies ∼0.5 log10 IU/m, a significant change in HCV viremia was defined as a change of HCV-RNA ≥ 1 log10IU/ml from baseline. Hepatitis flare was defined by an increase of ALT level to ≥ 3 times upper limit of normal (or >170 IU/ml). Results: Five HCV-infected cancer patients treated with lenalidomide were studied. All the patients were males with a median age of 56 years. They had multiple myeloma (n=4) or large B-cell lymphoma (n=1). Four patients had HCV genotype 1 (80%) and 1 had genotype 2 (20%). Two patients (40%) were cirrhotics. The 5 patients studied received 6 different lenalidomide-containing regimens: 2 with lenalidomide monotherapy, 2 lenalidomide + rituximab and 2 lenalidomide + steroids. HCV-RNA levels were measured between week 4 (1, 17%) and week 12 (5, 83%) on lenalidomide treatment. A decrease of HCV-RNA was seen with all the 6 regimens (100%) (Figs 1A, 1B and 1C). Nonetheless, a significant decrease (>1 log10IU/ml) was noted in 4 out of the 6 regimens: two on lenalidomide monotherapy (1.21 and 1.49 log10IU/ml) and two on lenalidomide + rituximab (1.15 and 1.3 log10IU/ml). Hepatitis flare was only seen in one patient treated with lenalidomide + rituximab but he did not have concomitant HCV-RNA changes. Conclusion: Unlike thalidomide,lenalidomide does not cause HCV reactivation. On the contrary, this agent seems to inhibit HCV replication. Figure 1 Figure 1. Disclosures Samaniego: Karus Therapeutics: Research Funding. Torres:Pfizer: Other: Scientific advisor; Theravance Biopharma: Other: Scientific advisor; Astellas Pharma: Other: Scientific advisor; Novartis: Other: Scientific advisor; Genentech: Other: Scientific advisor; Janssen Pharmaceuticals: Other: Scientific advisor; Vertex Pharmaceuticals: Other: Scientific advisor, Research Funding; Merck & Co.: Other: Scientific advisor, Research Funding; Gilead Sciences: Other: Scientific advisor, Research Funding.
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Nai, Wei, Lanfei Ma, and Yidan Xing. "Teaching Effect and Reform Strategies on Graduation Design for Undergraduates in Information Related Majors in Independent College Based on Psychological Identity." International Journal of Information and Education Technology 11, no. 1 (2021): 35–40. http://dx.doi.org/10.18178/ijiet.2021.11.1.1486.
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The annual graduation design in universities is the final cultivation process of the comprehensive professional competencies for undergraduates before they end their college career, and is also an important component in the tasks of undergraduate education. Teaching effect of graduation design on one hand depends on the foundation and application ability of professional knowledge of each student, and also depends on the psychological identity on advisor and the topic chosen from the student point of view on the other hand. In this paper, undergraduates who have all finished their graduation design in Department of Electronic and Information Engineering in Independent College T from the year 2017 to 2019 have been set as study objects, by deeply investigating students’ attitudes toward advisors and topics chosen from questionnaire survey, and by analyzing the grade point averages (GPA) of students, the relationship between psychological identity on advisor as well as topic chosen and the teaching effect of graduation design for each student has been found out, and related reform strategies on teaching methods has been discussed.
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Soriano, Alex, Laura A. Puzniak, Matteo Bassetti, et al. "1612. Evaluation of the Use of Ceftolozane/Tazobactam for the Treatment of ESBL-producing Enterobacterales Infections Using International Data from SPECTRA (Study of Prescribing Patterns and Effectiveness of Ceftolozane/Tazobactam Real World Analysis)." Open Forum Infectious Diseases 7, Supplement_1 (2020): S800. http://dx.doi.org/10.1093/ofid/ofaa439.1792.
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Abstract Background There is a paucity of data on outcomes of patients with severe ESBL-producing Enterobacterales infections treated with empiric or directed ceftolozane/tazobactam (C/T). This study looked at the treatment patterns and outcomes associated with C/T use in the treatment of ESBL-producing Enterobacterales. Methods Data were collected from an international cohort of 32 hospitals in 6 countries as part of SPECTRA, a retrospective multicenter database of C/T use globally, from 2016 – 2019. All adult patients with an ESBL positive Enterobacterales sterile site culture and treated with ≥ 48 hours of C/T were eligible. Outcomes assessed were clinical success, 30-day mortality from index event and readmission. Results There were 59 patients with 121 ESBL positive isolates. Blood and urine were the most common sites of infection at 19.8% each, followed by respiratory (18.2%). E. coli (50%) and K. pneumoniae (30%) were the most common pathogens. On average patients had 2 positive ESBL isolates; median 1; range 1-15. Most patients had the same infection site and ESBL pathogen, however 13 had multi-site ESBL pathogens identified and only 2 had polymicrobial ESBL pathogens. Septic shock was observed in 14 (24%) patients; 29 (49%) were in the ICU at the onset of infection. The most common comorbid conditions were immunocompromised hosts (37%) and cardiac disease (32%). 29% of patients were transplant recipients, and 28% had a CrCl < 50 ml/min. In most patients (71%), C/T was given as directed therapy (i.e., once culture results were available). C/T was given prior to culture results (i.e., as empiric therapy) in 17 (29%) patients, of which 77% had clinical success. C/T dose was 1.5 g in 49%. Only 2 of 10 patients with a respiratory source received the currently licensed 3 g dose. Overall, clinical success was observed in 36 (61%) patients. 30-day mortality was 12%. Readmissions occurred in 5%, of which 2 were infection related. Conclusion The role of newer non-carbapenem antibiotics in the treatment of severe ESBL infections is currently undefined. In a multinational patient database, C/T was found to be effective in severe infections caused by ESBL-producing Enterobacterales. Prospective studies are needed to further define the role of C/T in the setting of frequent drug-resistant Gram-negative pathogens. Disclosures Laura A. Puzniak, PhD, Merck (Employee) Matteo Bassetti, MD, Shionogi Inc. (Advisor or Review Panel member) Pamela Moise, PharmD, Merck & Co., Inc. (Employee, Shareholder) David Paterson, Accelerate (Speaker’s Bureau)BioMerieux (Speaker’s Bureau)BioMerieux (Advisor or Review Panel member)Entasis (Advisor or Review Panel member)Merck (Advisor or Review Panel member)Merck (Grant/Research Support)Merck (Speaker’s Bureau)Pfizer (Speaker’s Bureau)Shionogi & Co., Ltd. (Grant/Research Support)VenatoRx (Advisor or Review Panel member)
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Huang, Wei-chieh, Sung-Hsi Huang, and Chien-Ching Hung. "1020. Higher efavirenz mid-dose plasma concentration is associated with less weight gain among virologically suppressed people living with HIV." Open Forum Infectious Diseases 7, Supplement_1 (2020): S539—S540. http://dx.doi.org/10.1093/ofid/ofaa439.1206.
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Abstract Background Recently, an association between CYP2B6 516 G > T polymorphism and weight change was observed among African people living with HIV (PLWH) who were started on efavirenz(EFV)-based antiretroviral therapy (ART). We aimed to investigate the effect of EFV mid-dose plasma concentration on weight change among Taiwanese PLWH. Methods The medical records of adult PLWH who were taking EFV-containing ART and had been enrolled in a EFV therapeutic drug monitoring study between Oct 2009 and May 2014 were accessed. EFV mid-dose plasma concentration (C12) was determined in the previous study and those with serial weight measurements within 48 weeks around the time of EFV C12 measurement were included in the present study. The weight change in the 48 weeks and its associations with mid-dose EFV concentrations and CYP2B6 516 G > T polymorphism were examined by general estimating equations (GEE) after adjusting for age, baseline HIV viremia, baseline weight, and the companion backbone antiretroviral agents. Results One-hundred and fifteen predominantly male (94.8%) PLWH were included in this study (Table 1). The mean CD4 lymphocyte count was 542 cells/μL at the beginning of the observation and 94.8% achieved HIV viral suppression. Forty-four (38.3%) patients had non-wildtype CYP2B6 516 G > T polymorphism. On average, the included PLWH gained 0.8 kilogram at 48 weeks and the weight change did not differ among those with wildtype and non-wildtype CYP2B6 516 G > T(Figure 1). In the GEE models, CYP2B6 516 G > T polymorphism was not associated with weight change (p=0.81), instead, higher EFV C12 was found to be independently associated with less weight gain (p=0.045). Table 1. Baseline characteristics. Figure 1. The absolute weight (A) and weight change from baseline (B) among patients with wildtype and non-wildtype CYP2B6 516G>T polymorphism. Conclusion Our findings support that increased EFV exposure may have a negative effect on weight gain. Disclosures Chien-Ching Hung, MD,PHD, Abbvie (Advisor or Review Panel member, Speaker’s Bureau)Bristol-Myers Squibb (Speaker’s Bureau)Gilead Sciences (Advisor or Review Panel member, Speaker’s Bureau)Janssen (Grant/Research Support, Advisor or Review Panel member)Merck (Grant/Research Support)ViiV (Grant/Research Support, Advisor or Review Panel member, Speaker’s Bureau)
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Schuchert, A., and W. Brunekreeft. "775 T-STAR interim results: therapy Advisor for optimising the pacemaker AF therapy." EP Europace 7, Supplement_1 (2005): 176. http://dx.doi.org/10.1016/eupace/7.supplement_1.176-a.
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Thomas, Toney K., and Diya Jose. "Adapting to Political Activism in Destination." Tourism 69, no. 3 (2021): 367–80. http://dx.doi.org/10.37741/t.69.3.3.
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The way of protest through hartal (general strike) has sparked heated debates about its impact on the tourism industry in Kerala. This paper is aimed in the viewpoint that political activism has adverse consequences on tourism in the state of Kerala which is seamlessly propagated through the Media. Through a thematic analysis of online texts published on trip advisor, this paper explores tourists’ perceptions and opinions of the implication of hartal on tourism in Kerala. Overall, our analysis reveals that hartal would not discourage tourists to visit Kerala, although many regarded that certain level of challenges at the destination will enhance the visitor experience. Importantly, our study also contends that the narratives about the ‘hartal’ produced and propagated online were often representative of political structures of power, which linked tourism to hartal irrespective of the real impact on tourism.
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Rolston, Kenneth V. I., Bahgat Gerges, Issam Raad, Samuel L. Aitken, Ruth Reitzel, and Randall Prince. "1375. In vitro Activity of Cefiderocol and Comparator Agents against Gram-Negative Isolates from Cancer Patients." Open Forum Infectious Diseases 5, suppl_1 (2018): S421—S422. http://dx.doi.org/10.1093/ofid/ofy210.1206.
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Abstract Background Gram-negative bacilli (GNB) are now the predominant cause of bacterial infection in cancer patients (CP). Many GNB are problematic because they have become resistant to commonly used antibiotics. Cefiderocol (CFDC), a novel siderophore cephalosporin, is active against a wide spectrum of GNB. We evaluated its in vitro activity and that of eleven comparator agents against GNB isolated from CP. Methods A total of 341 recent GNB blood isolates from CP were tested using CLSI approved methods for MIC determination by broth microdilution. Comparator agents were amikacin (A), aztreonam (AZ), ceftazidime (CZ), ceftazidime/avibactam (CAV), cefepime (CEF), ciprofloxacin (CIP), colistin (CL), meropenem (MR), ceftolozane/tazobactam (C/T), tigecycline (TG), and trimethoprim/sulfamethoxazole (T/S). Results CFDC MIC90s as mg/L were: S. maltophilia [50 isolates] 0.25, E. coli (ESBL−) [50 isolates] 0.5, E. coli (ESBL+) [51 isolates] 2.0, K. pneumoniae (ESBL− and +) [60 isolates] 0.5; K. pneumoniae (CRE) [22 isolates] 2.0; P. aeruginosa (MDR) [32 isolates] 1.0; E. cloacae [27 isolates] 4.0; Achromobacter spp. [15 isolates] 0.12. CFDC inhibited P. agglomerans, Burkholderia spp., Sphingomonas spp., Ochrobactrum spp. at ≤1 mg/L [23 total isolates] and Elizabethkingia spp. and R. radiobacter at ≤8 mg/L [11 total isolates]. Among comparator agents, only T/S had consistent activity against S. maltophilia. For E. coli (ESBL− and +) MR, TG, CAV, CL were most active. For K. pneumoniae (ESBL–and +) MR, CAV were most active. For K. pneumoniae (CRE) and P. aeruginosa (MDR), none of the comparators had significant activity. For E. cloacae, MR, A, CAV, TG were most active. Among the uncommon organisms, MR and TG had the greatest activity. Conclusion Although susceptibility breakpoints have yet to be determined, CFDC has significant activity (≤4 mg/L) against most problematic Gram-negative organisms causing infections in CP based on available pharmacokinetic/pharmacodynamic data. In particular, its activity against S. maltophilia was superior to the comparators. Also, it was the most active agent against P. aeruginosa (MDR) and K. pneumoniae (CRE). Based on our results, CFDC warrants clinical evaluation for the treatment of blood stream infections caused by GNB in CP. Disclosures K. V. I. Rolston, Merck: Investigator, Research grant; JMI Laboratories: Investigator, Research grant; Shionogi (Japan): Investigator, Research grant. B. Gerges, Shionogi: Collaborator, Research support. S. L. Aitken, Shionogi: Scientific Advisor, Consulting fee; Merck: Scientific Advisor, Consulting fee; Medicines Co: Scientific Advisor, Consulting fee; Achaogen: Scientific Advisor, Consulting fee; Zavante: Scientific Advisor, Consulting fee; R. Prince, Shionogi: Investigator, Research support. Merck: Investigator, Research support.
Dissertations / Theses on the topic "T Advisor"
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Bruns, Christoph. "Konstruktionsbegleitende Toleranzsimulation mit CETOL 6 σ unter Verwendung der GPS-Strategie DIN EN ISO 14638 und DIN EN ISO 8015". Universitätsbibliothek Chemnitz, 2017. http://nbn-resolving.de/urn:nbn:de:bsz:ch1-qucosa-225869.
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Die geometrische Produktspezifikation (GPS) ist für Unternehmen eine wesentliche Triebfeder um sich in Konstruktions- und Entwicklungsprozessen neu auszurichten. Mit der 3-dimensionalen Bemaßung an der CAD-Geometrie sollen alle Aspekte der Geometriebeschreibung datenneutral umgesetzt werden. Dazu gehören Toleranzdefinitionen die den Anspruch der Funktion, der Fertigbarkeit und der Messtechnik erfüllen. Die verfügbaren Werkzeuge zur normgerechten Toleranzdefinition am 3D-Teil haben sich in Creo 4 mit dem GD&T Advisor nochmals deutlich erweitert. Dies wird in diesem Vortrag mit dem Fokus auf die Toleranzanalyse in Creo 4 und der neuen CETOL Version 9 aufgezeigt.
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Esdaile, Michael James. "Rhetoric vs practice : a re-examination of the 1916 Arab Revolt's advisers." Thesis, McGill University, 2005. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=83181.
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The First World War's 1916 Arab Revolt has become, in the West, a renowned episode in part because of the presence of one dominating character: T.E. Lawrence. However, "Lawrence of Arabia" is only the most prominent of the many Western agents sent to advise the Revolt. The narratives of these advisers have come to dominate the most Westerners popular conception of the Arab uprising. Most scholars have portrayed the British advisers to the Arab Revolt as "pro-Arab." The aim of this thesis is to challenge that portrayal through a careful analysis of the writings (published and unpublished) and actions of the four advisers: T.E. Lawrence, Sir Ronald Storrs, Major Sir Hubert Young, Lt Col. Sir Percy Joyce.<br>I argue for a more subtle, complex, heterogeneous version of the advisers Pro-Arab approach. By examining the advisers' published accounts and the available archival resources the contrast between the rhetoric surrounding their legends and the actual practice of their war experiences will be laid bare. The goal of the thesis is to use primary sources to demonstrate, in various areas of their relationships with Arabs, a discourse of superiority versus inferiority. This work has consequently attempted to present a less altruistic agenda emerging from the advisers' wartime conduct. In its place I have demonstrated numerous instances where they coerced and enforced their own interpretation of Arab desires and even an "Arab" identity onto the Revolt itself and furthermore, cemented these interpretations into Western popular culture.
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Schneider, Frederick W. (Frederick Walter) 1959. "Advising the ARVN: Lieutenant General Samuel T. Williams in Vietnam, 1955-1960." Thesis, University of North Texas, 1990. https://digital.library.unt.edu/ark:/67531/metadc504626/.
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Beginning in 1954, the United States Army attempted to build a viable armed force in South Vietnam. Until the early 1960s, other areas commanded more American attention, yet this formative period was influential in later United States involvement in Vietnam. This thesis examines United States advisory efforts from 1955 to 1960 by analyzing the tenure of Lieutenant General Samuel T. Williams as Chief of the Military Assistance Advisory Group in South Vietnam. During Williams's tenure, the communist forces in the north began the guerrilla insurgency in earnest. Williams's failure to respond to this change has been justly criticized; yet his actions were reflective of the United States Army's attitude toward insurgencies in the late 1950s.
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Lucas, D. Pulane. "Disruptive Transformations in Health Care: Technological Innovation and the Acute Care General Hospital." VCU Scholars Compass, 2013. http://scholarscompass.vcu.edu/etd/2996.
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Advances in medical technology have altered the need for certain types of surgery to be performed in traditional inpatient hospital settings. Less invasive surgical procedures allow a growing number of medical treatments to take place on an outpatient basis. Hospitals face growing competition from ambulatory surgery centers (ASCs). The competitive threats posed by ASCs are important, given that inpatient surgery has been the cornerstone of hospital services for over a century. Additional research is needed to understand how surgical volume shifts between and within acute care general hospitals (ACGHs) and ASCs. This study investigates how medical technology within the hospital industry is changing medical services delivery. The main purposes of this study are to (1) test Clayton M. Christensen’s theory of disruptive innovation in health care, and (2) examine the effects of disruptive innovation on appendectomy, cholecystectomy, and bariatric surgery (ACBS) utilization. Disruptive innovation theory contends that advanced technology combined with innovative business models—located outside of traditional product markets or delivery systems—will produce simplified, quality products and services at lower costs with broader accessibility. Consequently, new markets will emerge, and conventional industry leaders will experience a loss of market share to “non-traditional” new entrants into the marketplace. The underlying assumption of this work is that ASCs (innovative business models) have adopted laparoscopy (innovative technology) and their unification has initiated disruptive innovation within the hospital industry. The disruptive effects have spawned shifts in surgical volumes from open to laparoscopic procedures, from inpatient to ambulatory settings, and from hospitals to ASCs. The research hypothesizes that: (1) there will be larger increases in the percentage of laparoscopic ACBS performed than open ACBS procedures; (2) ambulatory ACBS will experience larger percent increases than inpatient ACBS procedures; and (3) ASCs will experience larger percent increases than ACGHs. The study tracks the utilization of open, laparoscopic, inpatient and ambulatory ACBS. The research questions that guide the inquiry are: 1. How has ACBS utilization changed over this time? 2. Do ACGHs and ASCs differ in the utilization of ACBS? 3. How do states differ in the utilization of ACBS? 4. Do study findings support disruptive innovation theory in the hospital industry? The quantitative study employs a panel design using hospital discharge data from 2004 and 2009. The unit of analysis is the facility. The sampling frame is comprised of ACGHs and ASCs in Florida and Wisconsin. The study employs exploratory and confirmatory data analysis. This work finds that disruptive innovation theory is an effective model for assessing the hospital industry. The model provides a useful framework for analyzing the interplay between ACGHs and ASCs. While study findings did not support the stated hypotheses, the impact of government interventions into the competitive marketplace supports the claims of disruptive innovation theory. Regulations that intervened in the hospital industry facilitated interactions between ASCs and ACGHs, reducing the number of ASCs performing ACBS and altering the trajectory of ACBS volume by shifting surgeries from ASCs to ACGHs.
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Lee, Chi Tung, and 李啟棟. "Determinants of financial advisor' performance─evidence form T bank." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/01495775870137123350.
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碩士<br>國立政治大學<br>行政管理碩士學程<br>97<br>The financial services industry is one of the most important sectors for the economic growth and development of a country. It also functions as the lifeline supporting the development of business and industry of a nation. The business track for the past three decades of the financial services industry indeed reflects the overall big picture of Taiwan's economic development. Financial development to the growth of economy is just as the circulation of the blood to the body. Once the financial institutions fail the role of financial intermediaries, economic growth will undoubtedly have a grave impact resulting in a lot of social problems. Since 2003, Taiwanese financial holding companies and banks have been trying hard to develop wealth management business. T-Bank engaged in this business on July 1, 2007, which is the latest bank to start wealth management business in the industry. This study is to investigate the impact of demographic variables toward job performance, especially to the financial advisors in T-Bank, based on the operating characteristics of financial management market. The research results can provide valuable suggestions to T-Bank in terms of hiring, training and management of financial advisors, which can help to actively expand its wealth management business and make it a leading role in the industry.
Using the mailed questionnaire method, 127 copies of questionnaire had been sent out to all the financial advisers of the T-Bank. All the data were analyzed by statistical software Limped 9.0. The empirical model was then utilized to verify all the hypotheses. The major findings of this study are as follows:
There are significant differences between the work performance and the education level of the advisers, their serving area, the language they use when communicate with customers; their daily working hour and the number of VIP customers in individual account has significant positive influence to the work performance. The number of certificate each advisor possesses has significant negative influence to the work performance; conversing in Mandarin Chinese in central and southern Taiwan has significant negative influence to the work performance.
T-bank will gain tremendous progress in wealth management business if it adopts the proposed suggestions in this study. It will also have strong competitive advantages among the industry. Its business will flourish and have the top rank in market shares.
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Dalili, Shadi. "Synthesis and catalytic applications of aziridine-containing scaffolds." 2005. http://link.library.utoronto.ca/eir/EIRdetail.cfm?Resources__ID=232714&T=F.
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Tsai, Li-Ting, and 蔡麗婷. "Business Model Analysis of Robo-Advisor Startups in Taiwan: Case Studies of Company T and Company F." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/vprx2v.
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Tu-Shu-Ying and 涂淑嫈. "The Correlation among Personality Traits of Financial Advisor, Brand Advantages and Work Performance – a Case Study of T Bank." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/sbj68t.
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碩士<br>淡江大學<br>保險學系保險經營碩士在職專班<br>106<br>Title: The Correlation among Personality Traits of Financial Advisor, Brand
Advantages and Work Performance – a Case Study of T Bank
University/Department (Institute)/Group: Executive Master’s Program of Business
administration (EMBA) in Insurance Management, Tamkang University.
Page:109
Graduation date and abstract classification: June,2018, Abstract of academic dissertation
Student: Tu Shu Ying Advising professor: Dr. Hau Chung Ren
涂淑嫈 郝充仁
Abstract:
As domestic banks are entering the meager-profit era, the development of wealth management industry is bringing more revenue to banks. As a result, those financial holding companies, one after another, have established wealth management departments to provide customized wealth management solutions for clients. However, products of various banks are subject to laws and regulations and therefore are similar. Thus the work performance of financial advisors has become critical for banks to achieve
sustainable operation. In view of this, a questionnaire survey was adopted with financial advisors of T Bank as respondents to explore the relationship among personality traits of financial advisor, brand advantages and work performance. A total of 145 questionnaires were distributed, among which 128 valid questionnaires were collected with collection rate of 88.28%. The data collected from the survey were analyzed with descriptive statistics, independent sample t test, one-way analysis of variance, multiple regression analysis and other statistical methods and the following conclusions were reached:
1. The personality traits of financial advisors from the north are inclined to be more diligent and prudent, kind, and open.
2. Those financial advisors who are recruited externally by the bank have relevantly higher awareness of brand awareness.
3. There is no difference of work performance among financial advisors of different background variables.
4. The personality traits of financial advisors have no significant impact on brand advantages.
5. The personality traits of financial advisors have no significant impact on work performance.
6. Brand image, brand marketing, and brand recognition have significant impact on work performance.
Keywords: personality traits, brand advantage, work performance
According to “TKU Personal information Management Policy Declaration”the personal information collected on this form is limited to this application only.This form will be destroyed directly over the deadline of reservations.
表單編號：ATRX-Q03-001-FM030-02
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Hirata, Jun. "Do school councils empower students? : two Japanese case studies." 2004. http://link.library.utoronto.ca/eir/EIRdetail.cfm?Resources__ID=80188&T=F.
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Yuen, Elaine. "The experiences of Chinese women and school councils in Toronto." 2005. http://link.library.utoronto.ca/eir/EIRdetail.cfm?Resources__ID=362486&T=F.
Full textBooks on the topic "T Advisor"
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Mitchell, Bruce. Environmental studies centers development in Indonesia project: End of assignment report : water managemen[t] short term advisor[s]hip for Universitas Gadjah Mada (UGM), Yogyakarta. Dalhousie University for Proyek Pengembangan Pusat Studi Lingkungan, Direktorat Jenderal Pendidikan Tinggi, Departemen Pendidikan dan Kebudayaan, 1996.
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Commissions, North Dakota Governor Schafer's Task Force on Boards and. Boards and commissions: Task Force report to Governor Edward T. Schafer. The Task Force, 1994.
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Franks, Julian R. Risk, regulation, and investor protection: The case of investment management. Clarendon Press, 1989.
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United States. Congress. Senate. Committee on Banking, Housing, and Urban Affairs. Nominations of: Melvin L. Watt, Jason Furman, Kara M. Stein, Michael S. Piwowar, and Richard T. Metsger: Hearing before the Committee on Banking, Housing, and Urban Affairs, United States Senate, One Hundred Thirteenth Congress, first session, on nominations of: Melvin L. Watt, of North Carolina, to be director, Federal Housing Finance Agency; Jason Furman, of New York, to be a member and chairman, Council of Economic Advisers; Kara M. Stein, of Maryland, to be a member, Securities and Exchange Commission; Michael S. Piwowar, of Virginia, to be a member, Securities and Exchange Commission; Richard T. Metsger, of Oregon, to be a member, National Credit Union Administration Board, June 27, 2013. U.S. Government Printing Office, 2013.
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(Canada), National Advisory Board on Science and Technology. Healthy, wealthy and wise : a framework for an integrated federal science and technology strategy : report of the National Advisory Board on Science and Technology =: La santé, la richesse et la sagesse : cadre pour une stratégie fédérale en matière de S-T intégrée : rapport du Conseil consultatif national des sciences et de la technologie. National Advisory Board on Science and Technology = Conseil consultatif national des sciences et de la technologie, 1995.
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Nominations of Mark W. Olson, Susan Schmidt Bies, James E. Gilleran, Allan I. Mendelowitz, Franz S. Leichter, John T. Korsmo, Eduardo Aguirre, Jr., and Randall S. Kroszner: Hearings before the Committee on Banking, Housing, and Urban Affairs, United States Senate, One Hundred Seventh Congress, first session on nominations of Mark W. Olson, of Minnesota, to be a member of the Board of Governors of the Federal Reserve System; Susan Schmidt Bies, of Tennessee, to be a member of the Board of Governors of the Federal Reserve System; James E. Gilleran, of California, to be the Director of the Office of Thrift Supervision; Allan I. Mendelowitz, of Connecticut, Franz S. Leichter, of New York, and John T. Korsmo, of North Dakota, to be Directors of the Federal Housing Finance Board; Eduardo Aguirre, Jr., of Texas, to be First Vice President and Vice Chairman of the Export-Import Bank of the United States; Randall S. Kroszner, of Illinois, to be a member of the Council of Economic Advisers, October 17, 23, and November 15, 2001. U.S. G.P.O., 2002.
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Bond, Cornelius C. T. Rowe Price: The Man, the Company, and the Investment Philosophy. Wiley & Sons, Incorporated, John, 2019.
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Bond, Cornelius C. T. Rowe Price: The Man, the Company, and the Investment Philosophy. Wiley & Sons, Incorporated, John, 2019.
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T. Rowe Price: The Sage of Baltimore and the Phenomenally Successful Company He Created. Wiley & Sons, Incorporated, John, 2019.
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Hull, Mark, and Steven C. Reynolds. HIV in the critically ill. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0291.
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It has been over 30 years since the recognition of the acquired immune deficiency syndrome (AIDS), linked to infection with human immunodeficiency virus (HIV). Opportunistic infections arise in the setting of decreases in the CD4+ T-lymphocyte count. Advances in the safety, and effectiveness of combination antiretroviral therapy (cART) have led to substantial improvements in life-expectancy for individuals accessing successful therapy. As such individuals are likely to be admitted to the intensive care unit (ICU) for conditions un-related to HIV, although presentations due to opportunistic infections and malignancies must be considered in those with previously undiagnosed infection or in those patients non-adherent to cART.. Individuals receiving cART must undergo careful evaluation for potential drug–drug interactions with other medications. Treatment interruption of cART is not generally advised due to risk of rebound viraemia and potential development of resistance.. Immune reconstitution inflammatory syndrome may be considered in those with recent cART initiation.
Book chapters on the topic "T Advisor"
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Njarui, D. M. G., M. Gatheru, and S. R. Ghimire. "Brachiaria Grass for Climate Resilient and Sustainable Livestock Production in Kenya." In African Handbook of Climate Change Adaptation. Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-45106-6_146.
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AbstractBrachiaria grass is a “climate smart” forage that produces high amount of palatable and nutritious biomass for livestock and performs well in infertile soils, sequesters carbon in soil, and provides several environmental benefits. The objective of the study was to validate the productivity of Brachiaria grass and upscale the suitable cultivars for improved livestock feed resources in Kenya. We assume integrating Brachiaria grass into mixed crop-livestock system will enhance feed availability and livestock productivity, leading to increased food and nutrition security. Farmer participatory approach was adopted to evaluate and promote four Brachiaria grass (Brachiaria decumbens cv. Basilisk, B. brizantha cvs. Xaraes, Piata, and MG-4) in the Central Highland and Eastern Midland of Kenya. The extension/advisory approaches used to promote Brachiaria grass cultivars included field days, village knowledge centres, agricultural shows, posters, and linkages with other institutions through multi-actor platform established under the InnovAfrica project. Generally, Brachiaria grass cultivars were more productive than the control (Rhodes grass) in most harvests reaching peak of 5.1–7.7 t/ha in the fifth harvest. For Rhodes grass, DM was less than 4 t/ha in all harvest and died by sixth harvest. Similarly, based on farmers’ evaluation using phenotypic traits, the Brachiaria grass cultivars had higher score than Rhodes grass except cv. Piata. The mean score ranged from 2.75 to 3.19 for Brachiaria cultivars, while for Rhodes the mean score was 2.63. Within 2 years of intervention, over 4000 farmers in the 2 project sites and additional 1500 farmers from other parts of the country have planted the Brachiaria grass. The demand for Brachiaria grass seeds is increasing due to benefits gained, e.g., increased milk production from dairy cattle fed on the grass. Our study will quantify the associated benefits from cultivation of Brachiaria grass with respect to a set of ecological, food and nutrition security, and social-economic indicators.
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"T." In Geriatric Clinical Advisor. Elsevier, 2007. http://dx.doi.org/10.1016/b978-032304195-9.50042-0.
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"T." In Geriatric Clinical Advisor. Elsevier, 2007. http://dx.doi.org/10.1016/b978-032304195-9.50063-8.
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"T." In Geriatric Clinical Advisor. Elsevier, 2007. http://dx.doi.org/10.1016/b978-032304195-9.50084-5.
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"T." In Geriatric Clinical Advisor. Elsevier, 2007. http://dx.doi.org/10.1016/b978-032304195-9.50019-5.
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"T." In Ferri's Clinical Advisor 2013. Elsevier, 2013. http://dx.doi.org/10.1016/b978-0-323-08373-7.00029-7.
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"T." In Ferri's Clinical Advisor 2013. Elsevier, 2013. http://dx.doi.org/10.1016/b978-0-323-08373-7.00055-8.
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"T." In Ferri's Clinical Advisor 2013. Elsevier, 2013. http://dx.doi.org/10.1016/b978-0-323-08373-7.00081-9.
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"T." In Ferri's Clinical Advisor 2013. Elsevier, 2013. http://dx.doi.org/10.1016/b978-0-323-08373-7.00106-0.
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Pardew, James W. "International Donors." In Peacemakers. University Press of Kentucky, 2018. http://dx.doi.org/10.5810/kentucky/9780813174358.003.0017.
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Early efforts to raise money for T&E falter. An international donor conference in Ankara, sponsored by the US and Turkey, also fails to secure funding. President Clinton dispatches Presidential Advisor Mack McLarty to the Middle East in a successful effort to raise funds in Saudi Arabia, the UAE, and Kuwait. Pardew raises additional money from the Sultan of Brunei. The State Department sets up an elaborate financial structure to account for donor money and to reduce the potential for corruption.
Conference papers on the topic "T Advisor"
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Bhatti, Nina, Harlyn Baker, Hui Chao, et al. "Mobile cosmetics advisor: an imaging based mobile service." In IS&T/SPIE Electronic Imaging, edited by Reiner Creutzburg and David Akopian. SPIE, 2010. http://dx.doi.org/10.1117/12.840303.
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Ramaswamy, Sanjay, Jami J. Shah, and Joseph K. Davidson. "Computer Aided GD&T Advisor Based on Y14.5 Conformance and Good Practice." In ASME 2001 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. American Society of Mechanical Engineers, 2001. http://dx.doi.org/10.1115/detc2001/dfm-21172.
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Abstract Contemporary CAD systems support GD&T specifications simply as textual attributes which does not facilitate validation of dimensioning and tolerancing. The Y14.5 tolerance standard is quite complex and many engineers are not quite familiar with all this intricacies. A few expert systems have been developed for GD&T support but they typically focus on tolerance values and their cost consequences. This paper presents the design and implementation of an integrated system for specification and automatic validation of dimensioning and tolerancing schemes in conformance with Y14.5. The validation includes not only tolerance values but choice of datums and datum reference frames. Additionally, the GD&T specifications are checked against good practice rules. This paper also provides a compilation of such rules from a variety of sources.
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Wu, Yanyan, Jami J. Shah, and Joseph K. Davidson. "Rationalization and Computer Modeling of GD&T Classes." In ASME 2002 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. ASMEDC, 2002. http://dx.doi.org/10.1115/detc2002/cie-34482.
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The main focus of this research is to develop a mathematical model for GD&T (Geometric Dimensioning and Tolerancing) to support tolerance specification, validation and tolerance analysis. The model should be built on the clear definition of GD&T, both in terms of semantics and syntax. The current tolerance standards (Y14.5M-1994 and ISO 1101-1983) have many inconsistencies. We present a rational basis for GD&T by examining the basic elements involved in geometric variation and their interrelations. Tolerance classes are defined in terms of a target, a datum reference frame, and geometric relations. The GD&T global model developed is the basis for a set of computer tools for automatically generating and validating dimension and tolerance specifications based on the functionality of the part, checking dimensioning status and tolerancing status, and applying GD&T advisor.
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Hagfarah, Ayman, and Mehdi Nazarinia. "Fundamental Study for the Power Tower’s High Concentrated Photovoltaic/Thermal-Combined Thermal Receiver." In ASME 2016 10th International Conference on Energy Sustainability collocated with the ASME 2016 Power Conference and the ASME 2016 14th International Conference on Fuel Cell Science, Engineering and Technology. American Society of Mechanical Engineers, 2016. http://dx.doi.org/10.1115/es2016-59051.
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The present study introduces fundamental aspects of a novel concentrated photovoltaics (CPV) technology. The technology is based on combining CPV/T receiver along with a solar thermal receiver. The combination is referred to as a High Concentrated Photovoltaic/Thermal - Combined receiver or HCPV/T-CT. The receiver is allocated in lieu of the conventional solar thermal receivers in the solar tower power plant schemes. The plant is designed to generate electricity and thermal energy simultaneously prior to integration with the conventional water desalination plant. The centralized generation in the CPV/T-CT receiver will remarkably simplify the complexity of the conventional solar power plants, and eliminate the piping networks’ energy losses in the CPV/T Dish tracking plants. The viability of the HCPV/T-CT power tower plant has also been investigated by; firstly, designing and simulating the plant performance using the System advisor model (SAM) software, and secondly, designing a prototype receiver and then deriving a mathematical model. The Levelised Cost Of Electricity/Energy (LCOE) was found to be 0.119 $/kWhe and 0.021 $/kWhe for electricity and energy generation, respectively, while the photovoltaic cells temperature maintained below the 90 °C.
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Tiku, Sanjay, Arnav Rana, Binoy John, and Aaron Dinovitzer. "Dent Screening Criteria Based on Dent Restraint, Pipe Geometry and Operating Pressure." In 2020 13th International Pipeline Conference. American Society of Mechanical Engineers, 2020. http://dx.doi.org/10.1115/ipc2020-9703.
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Abstract A safety advisory (2010-01), issued by the National Energy Board (NEB) in June 2010, referenced two incidents which were a result of a fatigue crack failure that occurred within shallow dents [1]. The dents in both instances were less than 6% (of the OD). Currently, there is no consensus on how shallow dents or shallow dents with stress concentrators, as called by the ILI tool, are assessed and acted upon. BMT Canada Ltd. (BMT) was contracted by the Canadian Energy Pipeline Association (CEPA) to develop a definition for shallow dents, and two levels of screening method for the integrity assessment of shallow restrained dents and unrestrained dents. These two levels are known as CEPA Level 0 and CEPA Level 0.5 dent integrity assessment techniques that may be applied without finite element modelling or detailed calculations. The BMT dent assessment finite element (FE) modeling method was used to develop an extensive database of dents for different pipe geometries (OD/t), indenter shapes, pipe grades, and indentation depths. The results of the FE modelling were used to develop trends for the stress magnification factors (KM) across the range of pipes and dents modelled. These trends are used as the basis for the Level 0 and Level 0.5 dent screening and assessment approaches that can be used for both unrestrained dents and shallow restrained dents. The results show that for low OD/t pipe geometry and/or low spectrum severity indicator (SSI) [2] dent fatigue life may not pose an integrity threat. These dent screening approached have been adopted in the API Recommended Practice 1183 Dent Assessment and Management, that is currently under development.
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Wood, P., M. Askarieh, and P. Lock. "The Nirex Coherent Approach to Achieving Criticality Safety." In ASME 2003 9th International Conference on Radioactive Waste Management and Environmental Remediation. ASMEDC, 2003. http://dx.doi.org/10.1115/icem2003-4839.
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The role of Nirex is to provide the UK with safe, environmentally sound and publicly acceptable options for the long-term management of radioactive materials. This will include all intermediate-level waste and some low-level waste (ILW and LLW). Nirex has developed a Phased Disposal Concept based on conditioning the wastes then isolating them deep underground. Based on this phased disposal concept, Nirex advises waste producers on the conditioning and packaging of radioactive waste. The ILW and LLW which comprise the ‘reference volume’ of the Phased Disposal Concept contain approximately 5 t Pu-239 and 28 t U-235. Nirex’s work is based on a number of standards for safety and environmental protection set by the Government. Three different Regulators ensure application of these standards in the transport, operation and post-closure phases. Therefore a coherent approach to criticality safety is required. The approach to criticality safety begins by avoiding criticality resulting from the way in which the waste is packaged, by controlling the package design including the level of fissile material. The concept safety assessments will support a screening level of approximately 5 g Pu-239 equivalent. In specific cases where waste producers indicate that their proposed packages will not comply with the screening level, package-specific criticality safety assessments can be incorporated into the concept through the change control process. Engineering measures are available to prevent criticality for such time as the waste packaging affords a high level of containment. In the long term, however, after deterioration of the physical containment provided by the waste packages, there would be the possibility of movement of fissile material out of the waste packages and subsequent accumulation into new configurations which could in principle lead to a criticality. It is conceivable that a criticality could adversely impact on the performance of a repository after closure because, for example, of the heat that would be produced affecting the engineered barriers. It is therefore necessary to consider the post-closure criticality safety of the repository concept. Nirex is currently undertaking a programme of work on ‘understanding criticality under repository conditions’. The aim of the programme is to obtain a better understanding of the processes that would control the nature and magnitude of a criticality under the particular conditions of the concept repository. An essential component of demonstrating criticality safety is to ensure waste packagers develop operating arrangements, and provide objective evidence in the form of criticality compliance assurance documentation, to demonstrate how fissile material will be controlled to meet levels defined in concept criticality safety assessments. This paper will describe the coherent approach and the processes by which it is applied.
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Logunova, Elena. "Morphological evolution of the fringe-belts of Krasnoyarsk." In 24th ISUF 2017 - City and Territory in the Globalization Age. Universitat Politècnica València, 2017. http://dx.doi.org/10.4995/isuf2017.2017.6052.
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Elena Logunova1Master of Urban Planning, Post-graduate student, 1Department of Urban Design and Planning, School of Architecture and Design, Siberian Federal University Address: 79 Svobodny pr., 660041 Krasnoyarsk, Russian Federation E-mail: ikukina@inbox.ru , el.lgnv@yandex.ruScientific adviser: Pd.D., Professor - I. V. Kukina Keywords: fringe-belt, Siberia, urban morphology, fixation lineConference topics and scale: Tools of analysis in urban morphologyThe fringe-belt concept is one of the most important concepts in urban morphology which provides a possibility to analyze existing urban layout. Urban fringe-belt phenomenon in cities of Siberia hitherto was poorly investigated. Thus, it constitutes an extremely broad research area.Phases and processes of formation, transformation and alienation in urban fringe-belts examines at the case of Krasnoyarsk from the 17th to mid 20th centuries. Krasnoyarsk was founded as a military stockaded town in 1628 during the first period of Siberia development and experienced several historical stages in the process of urban growth.Relation of changes in fringe-belts structure and political and socio-economic contexts is evidently at all periods of their physical formation. Natural fixation lines (topographic features, body of big river, and development of small river valley) and man-made fixation lines (city walls, railway corridor) influenced to the formation and evolution processes of fringe-belts and urban fabric generally. Railway was a turning point in the city expansion and contributed to overcoming of the power natural fixation line as the Yenisei river. Unlike the urban core, right bank of Krasnoyarsk formed as a linear city with specific fringe belts.Detailed analysis of Krasnoyarsk city plan indentifies several morphological units separated by fringe-belts. These fringe-belts are characterized by distinctive road network, variety of land-use units and heterogeneous forms in plan. It presents difficulties for reconstruction projects of modern city. An approach for renovation of these territories needs to depend on urban morphology methodology. ReferencesConzen M. P., Kai Gu, Whitehand J. W. R. (2012) ‘Comparing traditional urban form in China and Europe: a fringe-belt approach’ Urban Geography, 33, 1, p. 22–45.Whitehand J.W. R, Morton N. J. (2003) ‘Fringe belts and the recycling of urban land: an academic concept and planning practice’, Environment and Planning B: Planning and Design, volume 30, p.819- 839. Ünlü T. (2013) ‘Thinking about urban fringe belts: a Mediterranean perspective’, Urban Morphology 17 (1), p. 5-20.
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Kirk, Mark, Gary Stevens, Marjorie Erickson, William Server, and Hal Gustin. "Options for Defining the Upper Shelf Transition Temperature (Tc) for Ferritic Pressure Vessel Steels." In ASME 2015 Pressure Vessels and Piping Conference. American Society of Mechanical Engineers, 2015. http://dx.doi.org/10.1115/pvp2015-45307.
Full textAbstract:
This paper evaluates current guidance concerning conditions under which the analyst is advised to transition from a linear-elastic fracture mechanics (LEFM) based analysis to an elastic-plastic fracture mechanics (EPFM) based analysis of pressure vessel steels. Current guidance concerning the upper-temperature (T>c) for LEFM-based analysis can be found in ASME Section XI Code Case N-749. Also, while not explicitly stated, an upper-limit on the KIc value that may be used in LEFM-based evaluations is sometimes taken to be 220 MPa√m (a value herein referred to as KLIM). Evaluations of Tc and KLIM were performed using a recently compiled collection of toughness models that are being considered for incorporation into a revision to ASME Section XI Code Case N-830; those models provide a complete definition of all toughness metrics needed to characterize ferritic steel behavior from lower shelf to upper shelf. Based on these evaluations, new definitions of Tc and KLIM are proposed that are fully consistent with the proposed revisions to Code Case N-830 and, thereby, with the underlying fracture toughness data. Formulas that quantify the following values over the ranges of RTTo and RTNDT characteristic of ferritic RPV steels are proposed: • For Tc, two values, Tc(LOWER) and Tc(UPPER), are defined that bound the temperature range over which the fracture behavior of ferritic RPV steels transitions from brittle to ductile. Below Tc(LOWER), LEFM analysis is acceptable while above Tc(UPPER) EPFM analysis is recommended. Between Tc(LOWER) and Tc(UPPER), the analyst is encouraged to consider EPFM analysis because within this temperature range the competition of the fracture mode combined with the details of a particular analysis suggest that the decision concerning the type of analysis is best made on a case-by-case basis. • For KLIM, two values, KLIM(LOWER) and KLIM(UPPER), are defined that bound the range of applied-K over which ductile tearing will begin to occur. At applied-K values below KLIM(LOWER), ductile tearing is highly unlikely, so the use of the KIc curve is appropriate. At applied-K values above KLIM(UPPER), considerable ductile tearing is expected, so the use of the KIc curve is not appropriate. At applied-K values in between KLIM(LOWER) and KLIM(UPPER), some ductile tearing can be expected, so it is recommended to give consideration to the possible effects of ductile tearing as they may impact the situation being analyzed. These definitions of Tc and KLIM better communicate important information concerning the underlying material and structural behavior to the analyst than do current definitions.