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Dissertations / Theses on the topic 'T-cell depletion'

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1

Xiong, Ying. "Immuno-Magnetic T Cell Depletion For Allogeneic Hematological Stem Cell Transplantation." The Ohio State University, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=osu1205852981.

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2

Lara-Velasco, Oscar R. "Immunomagnetic cell separation: further applications of the quadrupole magnetic cell sorter." The Ohio State University, 2003. http://rave.ohiolink.edu/etdc/view?acc_num=osu1064338539.

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3

Hallett, William H. D. "Augmentation of natural killer cell-mediated anti-tumor effects by molecular targeting and regulatory T cell depletion." abstract and full text PDF (free order & download UNR users only), 2008. http://0-gateway.proquest.com.innopac.library.unr.edu/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3307716.

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4

Koh, Mickey Boon Chai. "Alloantigen specific T cell depletion from stem cell grafts for the prevention of graft versus host disease." Thesis, University College London (University of London), 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.392696.

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5

Ritsou, Elena. "The role of CD4 and CXCR4 mediated apoptosis in T cell depletion during HIV-1 infection." Thesis, Open University, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.390903.

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6

Mumtaz, Imtiaz M. [Verfasser]. "Effects of immunosuppressive drugs and CD4+ T-cell depletion on plasma cell survival in lupus prone (NZB/W) mice / Imtiaz M. Mumtaz." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2009. http://d-nb.info/1023710315/34.

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7

Engelschalt, Vivienne. "Mechanismen der antikörpervermittelten T-Zell-Depletion in vivo im Maus-Modell." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2010. http://dx.doi.org/10.18452/16234.

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Monoklonale Antikörper (mAk) werden bereits erfolgreich zur therapeutischen Depletion verschiedener Zellpopulationen in vivo verwendet, die Mechanismen der Depletion sind jedoch unklar geblieben. In dieser Arbeit wurden im Mausmodell die molekularen Grundlagen der CD4+ T-Zelldepletion (CD4 TZD) nach einmaliger Gabe (i.p.) von 100 µg des anti-CD4-mAk YTS191.1 untersucht. Dabei konnte eine starke Korrelation zwischen Depletion und der Modulation des CD4-Moleküls von der Oberfläche beobachtet werden. Gleichzeitig zeigten sich organabhängige Unterschiede, sowohl im zeitlichen Verlauf, als auch in
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8

Davies, Jeffrey Keith. "Selective depletion of alloreactive T cells to reduce graft-versus-host disease and enhance immune reconstitution post allogeneic haematopoietic stem cell transplantation." Thesis, University College London (University of London), 2005. http://discovery.ucl.ac.uk/1445462/.

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Non-selective T cell depletion reduces the incidence of severe graft-versus-host disease after allogeneic haematopoietic stem cell transplantation but the cost is delayed and disordered antigen-specific immune reconstitution and increased infection. A method of selective depletion of alloreactive donor T cells expressing the activation marker CD69 after co-culture with recipient stimulator cells in a mixed lymphocyte reaction has previously been shown to reduce alloreactivity, whilst retaining third party responses in vitro and in a mismatched murine model led to donor T cell engraftment with
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9

Xu, Jie. "Labeled and Label-less Magnetic Cell Separation and Analysis using Cell Tracking Velocimetry." The Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1335296870.

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10

Brozy, Johannes [Verfasser], Arne [Akademischer Betreuer] Skerra, and Patrick A. [Akademischer Betreuer] Baeuerle. "Novel T Cell-Engaging, Bispecific Antibodies for Depletion of Human Immunodeficiency Virus-Infected Cells / Johannes Brozy. Gutachter: Arne Skerra ; Patrick A. Baeuerle. Betreuer: Arne Skerra." München : Universitätsbibliothek der TU München, 2015. http://d-nb.info/1070981451/34.

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11

Shao, Mei. "Optimize the generation and depletion of alloreactive T cells for cellular therapy." Columbus, Ohio : Ohio State University, 2005. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1135261379.

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12

Gardner, Nicola Jane. "Costimulation blockade and selective depletion of activated T cells : therapeutic potential in transplantation." Thesis, King's College London (University of London), 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.440535.

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13

Schütte, Anja. "Depletion of CD8+ T-cells in goats experimentally infected with caprine arthritis encephalitis virus /." [S.l.] : [s.n.], 1999. http://www.ub.unibe.ch/content/bibliotheken_sammlungen/sondersammlungen/dissen_bestellformular/index_ger.html.

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14

Subudhi, Abinash kumar [Verfasser], Alexandra [Akademischer Betreuer] Schambony, Johann Helmut [Akademischer Betreuer] Brandstätter, Benedikt [Akademischer Betreuer] Kost, Alexandra [Gutachter] Schambony, and Dietrich [Gutachter] Petra. "Interaction of Ror2 with membrane microdomains and effect of cholesterol depletion on HEK 293-T and XTC cells / Abinash kumar Subudhi ; Gutachter: Alexandra Schambony, Dietrich Petra ; Alexandra Schambony, Johann Helmut Brandstätter, Benedikt Kost." Erlangen : Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 2020. http://d-nb.info/1213979072/34.

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15

Bull, Marta Eileen. "The role of the B7 co-stimulation pathway in feline immunodeficiency virus (FIV) and human immunodeficiency virus (HIV) associated T cell depletion." 2002. http://www.lib.ncsu.edu/theses/available/etd-11252002-142150/unrestricted/etd.pdf.

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16

Seitz, Stefanie [Verfasser]. "Generierung nicht-alloreaktiver T-Zellen durch Methotrexat, AICD (activation induced cell death) und immunomagnetische Depletion zur Immuntherapie nach Stammzelltransplantation / vorgelegt von Stefanie Seitz." 2005. http://d-nb.info/977930238/34.

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17

Dyachok, Oksana. "Modulation Of Cardiac Inward-Rectifier K+ Current IK1 By Intracellular K+ And Extracellular K+." 2011. http://hdl.handle.net/10222/14391.

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The inwardly-rectifying K+ current (IK1) is important for heart cell function because it sets the resting potential, influences cell excitability, and promotes repolarization of the action potential. My objective was to investigate the modulation of IK1 by extracellular K+ (K+o) and intracellular K+ (K+i). IK1 was recorded from whole-cell-configured guinea-pig ventricular myocytes that were dialyzed with Na+-free EGTA-buffered pipette-filling solution and bathed with Na+ or NMDG+ solution that contained agents that inhibit non-IK1 currents. Lowering K+o from standard 5.4 to 2 and 1 mM shifted
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18

Chen, Hsing-Yen, and 陳杏燕. "Enhancing efficacy of therapeutic EGFR DNA vaccine by depletion of CD25+ regulatory T cell in a mouse model of metastatic EGFR positive lung cancer." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/37931461382047177787.

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碩士<br>國立中興大學<br>生命科學院碩士在職專班<br>100<br>Previously, we reported that gene gun administration with naked DNA plasmids coding for the extracellular domains of the xenogenic EGFR gene can induce strong CTL activity and control endogenous EGFR -expressing LL2 lung tumors growth in subcutaneous tumor models in mice. However, our present study observed that gene gun administration EGFR DNA vaccines alone lack of effective against lung metastatic LL2 tumor in mouse model was established experimentally by an intravenous injection of tumors. Since regulatory T cells (Tregs) play an important role in immu
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19

Chih-Hung, Chuang, and 莊智弘. "Non-depleting anti-CD4 antibody induced T regulatory cells inhibit asthmatic responses in OVA-sensitized mice." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/28423788346719203195.

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碩士<br>長庚大學<br>基礎醫學研究所<br>93<br>Asthma is a chronic inflammatory disease of the airways. This disease is characterized by the airway hyper responsiveness (AHR), increased serum IgE level, and the airway infiltration of eosinophils. YTS177 Ab is a non-depleting anti-CD4 monoclonal antibody. It has been used in vivo to induce Ag-specific immunological tolerance to T cell responses, including tissue allograft rejection and autoimmune diabetes. In this study, we tested with the injection of YTS177 Ab reduced the inflammatory response. YTS177 Ab tested in a chicken ovalbumin (OVA) hyper-sensitized m
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20

Richard, Jonathan. "Étude du rôle de la protéine Vpr du VIH-1 dans la modulation de la réponse immunitaire." Thèse, 2013. http://hdl.handle.net/1866/10118.

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L’infection par le VIH-1 est caractérisée par une activation chronique du système immunitaire et par une réduction graduelle du nombre de lymphocytes TCD4+, qui contribuent à une détérioration lente du système immunitaire menant à la phase SIDA. Paradoxalement, ce sont majoritairement des lymphocytes T CD4+ non infectés qui sont détruits et la cause de ce phénomène reste encore inconnue. Certaines protéines virales, dont la protéine accessoire Vpr, sont soupçonnées de jouer un rôle dans ce processus. Synthétisée tardivement, Vpr est incorporée à l’intérieur des virions, en plus d’être relâchée
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