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Relevant bibliographies by topics / T-cell receptor

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Academic literature on the topic 'T-cell receptor'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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Journal articles on the topic "T-cell receptor"

1

Y, Elshimali. "Chimeric Antigen Receptor T-Cell Therapy (Car T-Cells) in Solid Tumors, Resistance and Success." Bioequivalence & Bioavailability International Journal 6, no. 1 (2022): 1–6. http://dx.doi.org/10.23880/beba-16000163.

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CARs are chimeric synthetic antigen receptors that can be introduced into an immune cell to retarget its cytotoxicity toward a specific tumor antigen. CAR T-cells immunotherapy demonstrated significant success in the management of hematologic malignancies. Nevertheless, limited studies are present regarding its efficacy in solid and refractory tumors. It is well known that the major concerns regarding this technique include the risk of relapse and the resistance of tumor cells, in addition to high expenses and limited affordability. Several factors play a crucial role in improving the efficacy

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Robbins, Paul F. "T-Cell Receptor–Transduced T Cells." Cancer Journal 21, no. 6 (2015): 480–85. http://dx.doi.org/10.1097/ppo.0000000000000160.

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Sowka, Slawomir, Roswitha Friedl-Hajek, Ute Siemann, Christof Ebner, Otto Scheiner, and Heimo Breiteneder. "T Cell Receptor CDR3 Sequences and Recombinant T Cell Receptors." International Archives of Allergy and Immunology 113, no. 1-3 (1997): 170–72. http://dx.doi.org/10.1159/000237537.

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Akatsuka, Yoshiki. "IV. T-cell Receptor-engineered T Cells." Nihon Naika Gakkai Zasshi 108, no. 7 (2019): 1384–90. http://dx.doi.org/10.2169/naika.108.1384.

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Moskalev, Alexander V., Boris Yu Gumilevskiy, Vasiliy Ya Apchel, and Vasiliy N. Cygan. "T-cell receptor family, signal transduction, and transcription factors in T-cell immune response." Bulletin of the Russian Military Medical Academy 27, no. 1 (2025): 135–46. https://doi.org/10.17816/brmma636850.

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This study investigated signal transduction in T-lymphocytes, whose cell receptors are categorized into several groups based on their signaling mechanisms and the intracellular biochemical pathways they activate, including modular signaling proteins and adapter molecules that perform scaffolding or catalytic functions. Adapter proteins facilitate signaling complexes by linking various enzymes. Immune receptors, which are composed of integral membrane proteins from the immunoglobulin superfamily, interact with specific tyrosine-containing motifs within transmembrane signaling proteins in their

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Rabin, Ronald L., Matthew K. Park, Fang Liao, Ruth Swofford, David Stephany, and Joshua M. Farber. "Chemokine Receptor Responses on T Cells Are Achieved Through Regulation of Both Receptor Expression and Signaling." Journal of Immunology 162, no. 7 (1999): 3840–50. http://dx.doi.org/10.4049/jimmunol.162.7.3840.

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Abstract To address the issues of redundancy and specificity of chemokines and their receptors in lymphocyte biology, we investigated the expression of CC chemokine receptors CCR1, CCR2, CCR3, CCR5, CXCR3, and CXCR4 and responses to their ligands on memory and naive, CD4 and CD8 human T cells, both freshly isolated and after short term activation in vitro. Activation through CD3 for 3 days had the most dramatic effects on the expression of CXCR3, which was up-regulated and functional on all T cell populations including naive CD4 cells. In contrast, the effects of short term activation on expre

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Kamiya, Takahiro, Desmond Wong, Yi Tian Png, and Dario Campana. "A novel method to generate T-cell receptor–deficient chimeric antigen receptor T cells." Blood Advances 2, no. 5 (2018): 517–28. http://dx.doi.org/10.1182/bloodadvances.2017012823.

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Key Points Newly designed PEBLs prevent surface expression of T-cell receptor in T cells without affecting their function. Combined with chimeric antigen receptors, PEBLs can rapidly generate powerful antileukemic T cells without alloreactivity.

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Rosenberg, Kenneth M., and Nevil J. Singh. "Subset-specific neurotransmitter receptor expression tunes T cell activation." Journal of Immunology 200, no. 1_Supplement (2018): 47.22. http://dx.doi.org/10.4049/jimmunol.200.supp.47.22.

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Abstract T cells continually patrol and invade other tissues and are exposed to varying tissue-specific cues. Different tissues are typically innervated by neurons using characteristic neurotransmitters. Therefore, encounter with particular neurotransmitters has the potential to influence the tissue-specific behavior of T cells. Although neurons utilize a complex array of over 180 neurotransmitter receptor (NR) genes, we find that murine T cells in total express only a limited set (26 detected) of them. Furthermore, the expression is T cell subset-specific suggesting distinct functional roles.

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OMOTO, K., Y. Y. KONG, K. NOMOTO та ін. "Sensitization of T-cell receptor-αβ+ T cells recovered from long-term T-cell receptor downmodulation". Immunology 88, № 2 (1996): 230–37. http://dx.doi.org/10.1111/j.1365-2567.1996.tb00009.x.

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Grunewald, Johan, Ylva Kaiser, Mahyar Ostadkarampour, et al. "T-cell receptor–HLA-DRB1 associations suggest specific antigens in pulmonary sarcoidosis." European Respiratory Journal 47, no. 3 (2015): 898–909. http://dx.doi.org/10.1183/13993003.01209-2015.

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In pulmonary sarcoidosis, CD4+ T-cells expressing T-cell receptor Vα2.3 accumulate in the lungs of HLA-DRB1*03+ patients. To investigate T-cell receptor-HLA-DRB1*03 interactions underlying recognition of hitherto unknown antigens, we performed detailed analyses of T-cell receptor expression on bronchoalveolar lavage fluid CD4+ T-cells from sarcoidosis patients.Pulmonary sarcoidosis patients (n=43) underwent bronchoscopy with bronchoalveolar lavage. T-cell receptor α and β chains of CD4+ T-cells were analysed by flow cytometry, DNA-sequenced, and three-dimensional molecular models of T-cell rec

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Dissertations / Theses on the topic "T-cell receptor"

1

Soper, David Michael. "Interleukin-2 receptor and T cell receptor signaling in regulatory T cells /." Thesis, Connect to this title online; UW restricted, 2007. http://hdl.handle.net/1773/8344.

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Carson, Bryan David. "Impaired T cell receptor signaling in regulatory T cells /." Thesis, Connect to this title online; UW restricted, 2006. http://hdl.handle.net/1773/8337.

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Im, Jin Seon. "Molecular characterization of T cell receptors and non-MHC restricted T cell receptor binding peptides." Diss., The University of Arizona, 1999. http://hdl.handle.net/10150/284969.

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T cells recognize antigenic peptides presented by MHC molecules on antigen presenting cells (APC) through T cell receptors (TCRs). Since TCRs are very similar to antibodies in structure and genetics, TCRs might have the potential to bind free antigens as antibodies do. Here, peptides which bound TCRs irrespective of MHC molecules have been identified by screening "one-bead one-peptide" combinatorial libraries. Peptides: VRENAR, RTGNYV, GKMHFK, KDAVKR and RKPQAI bound recombinant Jurkat single chain T cell receptors (scTcrs). GKMHFK, KDAVKR and RKPQAI were also specific for natural TCRs on the

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Jiang, Ning. "Kinetic analysis of Fcγ receptor and T cell receptor interacting with respective ligands". Diss., Georgia Institute of Technology, 2005. http://hdl.handle.net/1853/26716.

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Low affinity Fcg receptor III (FcgRIII, CD16) triggers a variety of cellular events upon binding to the Fc portion of IgG. A real-time flow cytometry method was developed to measure the affinity and kinetics of such low affinity receptor/ligand interactions, which was shown as an easily operated yet powerful tool. Results revealed an unusual temperature dependence of reverse rate of CD16aTM dissociating from IgG. Except for a few studies using mammalian cell CD16s, most kinetics analyses use purified aglycosylated extracellular portion of the molecules, making it impossible to assess the impor

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Butcher, Sarah A. "T cell receptor genes of influenza A haemagglutinin specific T cells." Thesis, University College London (University of London), 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.315271.

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Sommermeyer, Daniel. "Generation of dual T cell receptor (TCR) T cells by TCR gene transfer for adoptive T cell therapy." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2010. http://dx.doi.org/10.18452/16051.

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Die Herstellung von T-Zellen mit definierten Spezifitäten durch den Transfer von T-Zellrezeptor (TCR) Genen ist eine effiziente Methode, um Zellen für eine Immuntherapie bereitzustellen. Eine besondere Herausforderung ist dabei, ein ausreichend hohes Expressionsniveau des therapeutischen TCR zu erreichen. Da T-Zellen mit einem zusätzlichen TCR ausgestattet werden, entsteht eine Konkurrenzsituation zwischen dem therapeutischen und dem endogenen TCR. Bevor diese Arbeit begonnen wurde war nicht bekannt, welche TCR nach einem Gen-Transfer exprimiert werden. Daher haben wir Modelle etabliert, in de

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Li, Xiaoying. "T cell receptor repertoires of immunodominant CD8 T cell responses to Theileria parva." Thesis, University of Edinburgh, 2015. http://hdl.handle.net/1842/19552.

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Previous research has provided evidence that CD8 T cells mediate immunity against infection with Theileria parva. However, the immunity induced by one parasite strain doesn‟t give complete protection against other strains and this is associated with parasite strain specificity of the CD8 T cell responses. There is evidence that such strain specificity is a consequence of the CD8 T cell responses of individual animals being focused on a limited number of immunodominant polymorphic peptide-MHC determinants. Dominant responses to the Tp2 antigen have been demonstrated in animals homozygous for th

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Wright, G. P. "Generation of antigen-specific regulatory T cells by T cell receptor gene transfer." Thesis, University College London (University of London), 2009. http://discovery.ucl.ac.uk/18952/.

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Regulatory T cells (Tregs) have shown considerable potential in the treatment of murine models of immuno-pathology. Whilst poly-clonal Tregs are able to suppress immuno-pathology in a number of models, the superiority of Ag-specific Treg treatment has been demonstrated using Tregs from T cell receptor (TCR)- transgenic animals. Translation of these promising results to the clinic has been hampered by difficulties in isolating or enriching the rare Ag-specific Tregs from the polyclonal population. Here I describe two distinct approaches to generate Ag-specific T cells with regulatory ability: f

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Moody, Anne Marie. "T-cell receptor studies in myasthenia gravis." Thesis, University of Oxford, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.337448.

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Palmer, M. S. "Studies on the murine T-cell receptor." Thesis, University of Oxford, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.379915.

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Books on the topic "T-cell receptor"

1

Gérard, Lefranc, ed. The T cell receptor factsbook. Academic Press, 2001.

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Liu, Chaohong, ed. T-Cell Receptor Signaling. Springer US, 2020. http://dx.doi.org/10.1007/978-1-0716-0266-9.

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Henwood, Judith Ann. T-cell receptor expression in antigen-specific human T-cell clones. University of Birmingham, 1993.

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Van den Elsen, Peter J., 1951-. The human T-cell receptor repertoire and transplantation. Springer Verlag, 1995.

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M, Davis Mark, and Buxbaum Joel, eds. T-cell receptor use in human autoimmune diseases. New York Academy of Sciences, 1995.

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R, Oksenberg Jorge, ed. The antigen T cell receptor: Selected protocols and applications. R.G. Landes, 1997.

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van den Elsen, Peter J. The Human T-Cell Receptor Repertoire and Transplantation. Springer Berlin Heidelberg, 1995. http://dx.doi.org/10.1007/978-3-662-22494-6.

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Farhan, Ayar Jawi. T cell receptor gene polymorphism and usage in rheumatoid arthritis. University of Manchester, 1997.

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9

M, Davis Mark, Kappler John, University of California, Los Angeles., and UCLA Symposium on the T Cell Receptor (1987 : Keystone, Colo.), eds. The T-cell receptor: Proceedings of a Smith Kline & French-UCLA symposium, held in Keystone, Colorado, April 26-May 1, 1987. A.R. Liss, 1988.

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Afshari, Jalil Tavakol. Analysis of T cell antigen receptor [beta]-chain gene repertoires in alloreactive T lymphocytes. University of Manchester, 1996.

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Book chapters on the topic "T-cell receptor"

1

Rojo, Jose M., Raquel Bello, and Pilar Portolés. "T-Cell Receptor." In Advances in Experimental Medicine and Biology. Springer New York, 2008. http://dx.doi.org/10.1007/978-0-387-09789-3_1.

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Loh, Dennis Y., Mark A. Behlke, and Hubert S. Chou. "T-Cell Receptor Genes." In The T-Cell Receptors. Springer US, 1988. http://dx.doi.org/10.1007/978-1-4684-5406-2_4.

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Marrack, Phillipa, Kathryn Haskins, Neal Roehm, et al. "The T-Cell Receptor." In Investigation and Exploitation of Antibody Combining Sites. Springer US, 1985. http://dx.doi.org/10.1007/978-1-4684-5006-4_30.

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Ceri, Howard, and Chris Mody. "The T-Cell Receptor." In Immunology, Infection, and Immunity. ASM Press, 2015. http://dx.doi.org/10.1128/9781555816148.ch13.

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Haskins, Kathryn, Neal Roehm, Charles Hannum, et al. "The Murine T Cell Receptor." In Human T Cell Clones. Humana Press, 1985. http://dx.doi.org/10.1007/978-1-4612-4998-6_2.

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Sam-Yellowe, Tobili Y. "T Cell Development and T Cell Receptor Structure." In Immunology: Overview and Laboratory Manual. Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-64686-8_13.

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Caccia, Nicolette, Rosanne Spolski, and Tak W. Mak. "Thymic Ontogeny and the T-Cell Receptor Genes." In The T-Cell Receptors. Springer US, 1988. http://dx.doi.org/10.1007/978-1-4684-5406-2_5.

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Rioufol, Catherine, and Christian Wichmann. "Receiving, Handling, Storage, Thawing, Distribution, and Administration of CAR-T Cells Shipped from the Manufacturing Facility." In The EBMT/EHA CAR-T Cell Handbook. Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-94353-0_7.

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Caccia, Nicolette, Barry Toyonaga, Nobuhiro Kimura, and Tak W. Mak. "The α and β Chains of the T-Cell Receptor." In The T-Cell Receptors. Springer US, 1988. http://dx.doi.org/10.1007/978-1-4684-5406-2_2.

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Kirsch, Ilan R., and Gregory F. Hollis. "The Involvement of the T-Cell Receptor in Chromosomal Aberrations." In The T-Cell Receptors. Springer US, 1988. http://dx.doi.org/10.1007/978-1-4684-5406-2_9.

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Conference papers on the topic "T-cell receptor"

1

Fang, Xing, Chenpeng Yu, Shiye Tian, and Hui Liu. "A large language model for predicting T cell receptor-antigen binding specificity." In 2024 IEEE International Conference on Bioinformatics and Biomedicine (BIBM). IEEE, 2024. https://doi.org/10.1109/bibm62325.2024.10822735.

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Wang, Haoyan, Yifei Huang, and Tianyi Zang. "MFTEP: A Multimodal Fusion Deep Learning Framework for T Cell Receptor-epitope Interaction Prediction." In 2024 IEEE International Conference on Bioinformatics and Biomedicine (BIBM). IEEE, 2024. https://doi.org/10.1109/bibm62325.2024.10821958.

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de Rooij, MAJ, DM Steen, D. Remst, et al. "10.04 A library of novel cancer testis specific T-cell receptors for T-cell receptor gene therapy." In iTOC8 – the 8th Leading International Cancer Immunotherapy Conference in Europe, 8–9 October 2021, Virtual Conference. BMJ Publishing Group Ltd, 2021. http://dx.doi.org/10.1136/jitc-2021-itoc8.4.

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Zijia, Cheng. "Chimeric-antigen Receptor T (CAR-T) Cell Therapy for Leukemia." In ICBET 2020: 2020 10th International Conference on Biomedical Engineering and Technology. ACM, 2020. http://dx.doi.org/10.1145/3397391.3397451.

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Sherwood, Anna M., Harlan Robins, Jonathan R. Fromm, et al. "Abstract 1895: Identifying clonal T-cell receptor sequences and monitoring recurrent/persistent disease by T-cell receptor repertoire profiling in patients with mature T-cell neoplasms." In Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1538-7445.am2014-1895.

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Davis, Nicholas S., Catherine Leites, Helicia Paz, et al. "Abstract 1496: KK-LC-1 targeting T cell receptor for adoptive T cell therapy." In Proceedings: AACR Annual Meeting 2021; April 10-15, 2021 and May 17-21, 2021; Philadelphia, PA. American Association for Cancer Research, 2021. http://dx.doi.org/10.1158/1538-7445.am2021-1496.

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Wu, Ling, Joanna Brzostek, Shvetha Sankaran, et al. "Abstract 1425: Chimeric antigen receptors based on T cell receptor-like antibodies." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.sabcs18-1425.

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Wu, Ling, Joanna Brzostek, Shvetha Sankaran, et al. "Abstract 1425: Chimeric antigen receptors based on T cell receptor-like antibodies." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.am2019-1425.

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Luo, Danhua. "Chimeric Antigen Receptor T-Cell Immunotherapy for Cancer." In BIBE2020: The Fourth International Conference on Biological Information and Biomedical Engineering. ACM, 2020. http://dx.doi.org/10.1145/3403782.3403802.

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Donaghey, Julie, Philippe Kieffer-Kwon, Troy Patterson, et al. "Abstract 2190: Engineering off-the-shelf T cell receptor fusion construct (TRuC) T cells." In Proceedings: AACR Annual Meeting 2020; April 27-28, 2020 and June 22-24, 2020; Philadelphia, PA. American Association for Cancer Research, 2020. http://dx.doi.org/10.1158/1538-7445.am2020-2190.

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Reports on the topic "T-cell receptor"

1

Knouse, Michael. Chimeric Antigen Receptor T Cell Therapy: A Review. Iowa State University, 2018. http://dx.doi.org/10.31274/cc-20240624-355.

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Iqbal, Fatiha. Chimeric Antigen Receptor (CAR) T Cell Immunotherapies for Leukemias and Lymphomas. Iowa State University, 2019. http://dx.doi.org/10.31274/cc-20240624-354.

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Weinberg, Andrew D. Tumor Specific CD4+ T-Cell Costimulation Through a Novel Receptor/Ligand Interaction. Defense Technical Information Center, 1999. http://dx.doi.org/10.21236/ada374764.

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Wiley, Don C., and David N. Garboczi. Structural Analysis of the Human T-Cell Receptor/HLA-A2/Peptide Complex. Defense Technical Information Center, 1997. http://dx.doi.org/10.21236/ada342257.

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Weinberg, Andrew D. Tumor Specific CD4+ T-Cell Costimulation Through a Novel Receptor Ligand Interaction. Defense Technical Information Center, 1998. http://dx.doi.org/10.21236/ada359629.

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Gray, Andrew. Enhancing the Efficacy of Prostate Cancer Immunotherapy by Manipulating T-Cell Receptor Signaling in Order to Alter Peripheral Regulatory T-Cell Activity. Defense Technical Information Center, 2009. http://dx.doi.org/10.21236/ada511997.

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Gray, Andrew. Enhancing the Efficacy of Prostate Cancer Immunotherapy by Manipulating T-Cell Receptor Signaling in Order to Alter Peripheral Regulatory T-Cell Activity. Defense Technical Information Center, 2011. http://dx.doi.org/10.21236/ada553485.

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Zhao, Kangjia, Jiwen Sun, Nanping Shen, et al. Treatment-Related Adverse Events of Chimeric Antigen receptor T-Cell (CAR-T) Cell Therapy in B-cell hematological malignancies in the Pediatric and Young Adult Population: A Systematic Review and Meta-Analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2022. http://dx.doi.org/10.37766/inplasy2022.7.0034.

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Bickel, Ulrich. Simultaneous Vascular Targeting and Tumor Targeting of Cerebral Breast Cancer Metastases Using a T-Cell Receptor Mimic Antibody. Defense Technical Information Center, 2014. http://dx.doi.org/10.21236/ada608026.

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Bickel, Ulrich. Simultaneous Vascular Targeting and Tumor Targeting of Cerebral Breast Cancer Metastases Using a T-Cell Receptor Mimic Antibody. Defense Technical Information Center, 2013. http://dx.doi.org/10.21236/ada586024.

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