Relevant bibliographies by topics / T cell receptor excision circles

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  2. Dissertations / Theses
  3. Book chapters

Academic literature on the topic 'T cell receptor excision circles'

Author: Grafiati
Published: 4 June 2021
Last updated: 13 February 2022

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Journal articles on the topic "T cell receptor excision circles"

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Yamanaka, Kei-ichi, Nikhil Yawalkar, David A. Jones, Daniel Hurwitz, Katalin Ferenczi, Sara Eapen, and Thomas S. Kupper. "Decreased T-Cell Receptor Excision Circles in Cutaneous T-Cell Lymphoma." Clinical Cancer Research 11, no. 16 (August 15, 2005): 5748–55. http://dx.doi.org/10.1158/1078-0432.ccr-04-2514.

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Fuleihan, Ramsay L. "DOCK8 deficiency, T cell receptor excision circles and newborn screening." Clinical Immunology 141, no. 2 (November 2011): 125–26. http://dx.doi.org/10.1016/j.clim.2011.08.002.

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Gul, Kiran A., Janne Strand, Rolf D. Pettersen, Henrik Brun, and Tore G. Abrahamsen. "T-cell Receptor Excision Circles in Newborns with Heart Defects." Pediatric Cardiology 41, no. 4 (March 13, 2020): 809–15. http://dx.doi.org/10.1007/s00246-020-02317-y.

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Somech, Raz. "T-cell receptor excision circles in primary immunodeficiencies and other T-cell immune disorders." Current Opinion in Allergy and Clinical Immunology 11, no. 6 (December 2011): 517–24. http://dx.doi.org/10.1097/aci.0b013e32834c233a.

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Miller, Jennifer M., and Lisa R. Forbes-Satter. "T-Cell Receptor Excision Circles in Newborns With Congenital Heart Disease." Pediatrics 146, Supplement 4 (December 2020): S376—S377. http://dx.doi.org/10.1542/peds.2020-023861kkkk.

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Ye, Ping, and Denise E. Kirschner. "Measuring Emigration of Human Thymocytes by T-Cell Receptor Excision Circles." Critical Reviews™ in Immunology 22, no. 5-6 (2002): 16. http://dx.doi.org/10.1615/critrevimmunol.v22.i5-6.80.

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Davey, Brooke T., Robert W. Elder, Michelle M. Cloutier, Nicholas Bennett, Ji Hyun Lee, Zhu Wang, Adrienne Manning, et al. "T-Cell Receptor Excision Circles in Newborns with Congenital Heart Disease." Journal of Pediatrics 213 (October 2019): 96–102. http://dx.doi.org/10.1016/j.jpeds.2019.05.061.

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Hsieh, Meng-Ying, Wan-Hsiang Hong, Jainn-Jim Lin, Wen-I. Lee, Kuang-Lin Lin, Huei-Shyong Wang, Shih-Hsiang Chen, Chao-Ping Yang, Tang-Her Jaing, and Jing-Long Huang. "T-cell receptor excision circles and repertoire diversity in children with profound T-cell immunodeficiency." Journal of Microbiology, Immunology and Infection 46, no. 5 (October 2013): 374–81. http://dx.doi.org/10.1016/j.jmii.2012.06.003.

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Lee, Wen-I., Jing-Long Huang, Syh-Jae Lin, Kuo-Wei Yeh, Li-Chen Chen, Liang-Shiou Ou, Tsung-Chieh Yao, et al. "Applying T-cell receptor excision circles and immunoglobulin κ-deleting recombination excision circles to patients with primary immunodeficiency diseases." Annals of Medicine 46, no. 7 (August 11, 2014): 555–65. http://dx.doi.org/10.3109/07853890.2014.941920.

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Hisazumi, Rinnosuke, Miya Kayumi, Ryuji Kikukawa, Tetsuo Nasu, and Masahiro Yasuda. "Detection and quantification of bovine signal joint T-cell receptor excision circles." Veterinary Immunology and Immunopathology 167, no. 1-2 (September 2015): 86–90. http://dx.doi.org/10.1016/j.vetimm.2015.06.010.

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Dissertations / Theses on the topic "T cell receptor excision circles"

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Duszczyszyn, Danielle Andrea. "T-cell receptor excision circle content in multiple sclerosis." Thesis, McGill University, 2004. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=82228.

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The pathogenesis of Multiple Sclerosis (MS), a demyelinating disease of the central nervous system (CNS) with associated early axonal damage, is poorly understood. Considerable data indicate that MS is an inflammatory-mediated autoimmune disease. Normally, the naive T-cell niche is maintained by homeostatic mechanisms and in MS, naive T-cells play a central role in the autoimmune response against CNS antigens. Naive T-cells are produced by the thymus and naive T-cell production by the thymus can be ascertained by quantifying signal joint T-cell receptor excision circles (sjTRECs); episomal products formed during V(D)J T-cell receptor rearrangement. Naive T-cells expressing CD31, a cell surface marker, are reported to be highly enriched with sjTRECs. It was hypothesized that in relapsing remitting MS (RRMS), some process significantly alters T-cell generation in the thymus, as measured by sjTREC content in naive CD4 and naive CD8 T-cells.
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Poulin, Jean-François 1974. "Quantitative and qualitative analysis of human de novo T cell production using T cell receptor alpha and beta excision circles." Thesis, McGill University, 2002. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=84415.

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The evaluation of human de novo T cell production is critical for a better understanding of T cell homeostasis and the immune reconstitution processes. The presence of a functional thymus post-puberty has been unsuspected due to the paucity of tools. This thesis provides direct evidence for a functional thymus, which can contribute to the diversity of the immune reconstitution in pathological situations where the immune system is severely destroyed. Through peripheral blood PCR-based quantification of TCR alpha and beta rearrangement excision/deletion circles (TREC), by-products of gene rearrangement events, we demonstrated that a diversified de novo T cell production occurs throughout life, even though thymic function decreases with age. De novo T cell production remains intact following allogenic hematopoietic stem cell transplantation (AHSCT) in the absence of graft-versus-host disease (GVHD) and therefore a reduced thymus function cannot be responsible for the long-lasting reduction in peripheral blood naive T cells observed in transplanted patients. As naive T cells from AHSCT patients have reduced levels of IL-7Ralpha chain (CD 127) expression, we propose that their low frequencies reflect an impaired naive T cell survival rather than thymic dysfunction as signaling through CD127 was previously reported to upregulate Bcl-2 expression. Evidence gathered in this thesis supports the concept that such naive T cells try to replenish themselves through enhanced levels of proliferation but fail to do so and likely die in the process.
Monitoring of the peripheral alpha and beta TREC ratio, a marker of intrathymic proliferation, demonstrated that HIV infection either induces the cellular depletion or inhibits the cell cycling of differentiating thymocytes. As intrathymic proliferation is important for both the magnitude and diversity of thymic function, the results of this thesis indicate that the replenishment of the naive T cell peripheral compartment through de novo T cell production is both quantitatively and qualitatively limited in HIV-infected individuals leading to the contraction of the peripheral T cell repertoire.
Although peripheral blood quantification of alpha and beta TREC can estimate peripheral blood RTE frequencies, reflective of thymopoiesis levels, it does not constitute a method that can lead to the characterization of this important T cell subset. To better understand the biology of RTEs, we engineered a transgene with restricted GFP expression in T cell that recently rearranged their TCR. This model would be very useful for the identification of molecules capable of modulating thymic function as well as serving as a source for obtaining a highly purified population of RTEs, then allowing the characterization of their gene expression profile.
Taken together, this thesis demonstrates the contribution of the adult thymus to immune reconstitution following AHSCT and during HIV infection.
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Levy, Ariel. "Elastografia e TRECs: contribuição para a avaliação do timo em crianças de baixa idade." Universidade de São Paulo, 2019. http://www.teses.usp.br/teses/disponiveis/5/5141/tde-20032019-145641/.

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O timo é um órgão linfoide primário, localizado em região mediastinal, cuja importância funcional é a diferenciação e maturação de todas as subpopulações de linfócitos T provenientes da medula óssea assim como a seleção de células autorreativas. Sua hipoplasia ou aplasia resultam em síndromes de imunodeficiência. Embora de vital importância, o estudo clínico de sua função não é rotineiro na prática clínica, o que pode ser atribuído a sua dificuldade de avaliação em razão de sua localização, necessidade de uso de métodos de imagem não inócuos ao paciente (tomografia computadorizada (TC), PET-SCAN) e complexidade das análises em sangue periférico de subpopulações de células T por citometria de fluxo e, mais recentemente, medição de T cell receptor excision circles (TRECs), por PCR. Um possível método da avaliação do timo sem radiação ionizante ou dor ao paciente seria a elastografia de timo por ultrassom e seu uso na prática clínica poderia substituir a TC, como ocorre na avaliação de lesões hepáticas ou mamárias. Objetivo - Este estudo se propõe a 1. Implantar este método na avaliação da função tímica, 2. Estabelecer valores de referência de TRECs na faixa etária estudada, 3. Investigar se há correlação entre os dois parâmetros. Métodos - Foram incluídas sessenta e quatro crianças de 0-5 anos em acompanhamento no ambulatório de cirurgia infantil sem doença sistêmica ou infecção aguda, e que iriam coletar amostra de sangue para exames pré-operatórios. Quarenta e oito destas coletaram amostra de sangue para avaliação de TRECs, vinte e nove realizaram elastografia num mesmo momento, porém apenas 13 destas apresentaram resultado confiável. A média da idade foi de 36 ± 16meses, predomínio do grupo foi masculino (75%), nascidos a termo (72%) e a principal intervenção cirúrgica foi do tipo urológica de pequeno porte. A elastografia mostrou média de 1,21 ± 0,24m/s, sem diferença significativa quando comparada ano a ano. Observamos uma média de TRECs de 195,6 ± 120,5 cópias/µL, mostrando valores significativamente mais altos quando comparados a adolescentes hígidos da base de dados do laboratório. Os valores de TRECs observados mostram uma ampla variabilidade na faixa etária estudada, sem diferença significativa quando separados por idade ano a ano. Não se encontrou correlação significativa entre a dureza do timo analisada à elastografia e valores de TRECs em sangue periférico. Concluímos que a elastografia é um método que possibilita a avaliação das dimensões e função do timo em crianças a partir de 2 anos de idade, entretanto estudos adicionais são necessários para que se possa recomendar a larga implantação deste método com essa finalidade
The thymus is a primary lymphoid gland responsible for the maturation of T cells as well as the immunological central tolerance. It has been a neglected organ by physicians, despite its relevance in early immunity. Thymic function can be indirectly measured by Computerized Tomography imaging and PET SCAN, T cell subpopulation flow cytometry. More recently, in the beginning of this century, a direct measurement represented by TRECs (T cell receptors excision circles) was developed. Classical thymic imaging has used ionized radiation, which poses a major risk for the pediatric patient and new techniques are needed. Objectives and methods - In this work, we tested the use of elastography ultrasound for the evaluation of the thymus in a group of < 5-year- old healthy children. In parallel, we measured TRECs in peripheral blood and compared the values obtained from both methods. We have reached sixty-four children at the pediatric surgery outpatients ambulatory, scheduled for minor surgeries. A sample of blood was taken during pre operatory and then patients were sent to the imaging service for elastography. Of all, sixty-four had undertaken TRECs and seventeen, elastography. The median age was 36 ±16 months and we had 75% of boys for surgical correction of urologic minor defects. The elastography results showed a median of 1.2 ± 0.24 m/s in all ages, the same stiffness as the liver, as shown in other works. Our median TREC/µL value was 195.6 ± 120.5 copies/µL showing a trend of reduction in older ages, and with statistical significance when compared with healthy teenagers\' values from the lab database. We concluded that elastography may be a good diagnostic tool for thymus evaluation, and additional works are needed for its recommendation in clinical practice. Our TRECs values showed a large variability, as also demonstrated in previous works, and a trend of reduction over age. We could not observe any significant correlation between elastography and TRECs values
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Theriault, Mylene A. "Development and Validation of Quantitative PCR Assays for DNA-Based Newborn Screening of 22q11.2 Deletion Syndrome, Spinal Muscular Atrophy, Severe Combined Immunodeficiency and Congenital Cytomegalovirus Infection." Thesis, Université d'Ottawa / University of Ottawa, 2013. http://hdl.handle.net/10393/30318.

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The development of new high throughput technologies able to multiplex disease biomarkers as well as advances in medical treatments has lead to the recent expansion of the newborn screening panel to include DNA-based targets. Four rare disorders; deletion 22q11.2 syndrome and Spinal Muscular Atrophy (SMA), Severe Combined Immunodeficiency (SCID) and Congenital Cytomegalovirus (CMV), are potential candidates for inclusion to the newborn screening panel within the next few years. The major focus of this study was to determine whether 5’-hydrolysis assays developed for the four distinct disorders with specific detection needs and analytical ranges could be combined on the OpenArray system and in multiplexed qPCR reactions. SNP detection of homozygous SMN1 deletions in SMA, CNV detection in the 22q11.2 critical region, and quantification of the SCID biomarker, T-cell receptor excision circles (TRECs) and CMV were all required for disease confirmation. SMA and 22q11.2 gene deletions were accurately detected using the OpenArray system, a first for the technology. The medium density deletion 22q11.2 multiplex successfully identified deletion carriers having either the larger 3 Mb deletion or the smaller 1.5 Mb deletions. Both TREC and CMV targets were detected but with a decrease in sensitivity when compared to their singleplex counterparts. Lastly, copy number detection of the TBX1 was performed when multiplexed with the TREC assay, without a decrease in detection limit of either assay. Here, we provide proof of principal that qPCR multiplexing technologies are amenable to implementation with a newborn screening laboratory.
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Book chapters on the topic "T cell receptor excision circles"

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Lynch, Heather E., and Gregory D. Sempowski. "Molecular Measurement of T Cell Receptor Excision Circles." In Methods in Molecular Biology, 147–59. Totowa, NJ: Humana Press, 2013. http://dx.doi.org/10.1007/978-1-62703-290-2_12.

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Dion, Marie-Lise, Rafick-Pierre Sékaly, and Rémi Cheynier. "Estimating Thymic Function Through Quantification of T-Cell Receptor Excision Circles." In Immunological Tolerance, 197–213. Totowa, NJ: Humana Press, 2007. http://dx.doi.org/10.1007/978-1-59745-395-0_12.

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Loeffler, Juergen, Holger Hebart, Lutz Lochmann, Thomas Daikeler, Peter Bader, Ralf Bauer, Kathrin schmidt, and Hermann Einsele. "Quantification of δRec-ψJα Signal Joint T-Cell Receptor Excision Circle DNA in Patients after Autologous and Allogeneic Stem Cell Transplantation." In Rapid Cycle Real-Time PCR — Methods and Applications, 53–59. Berlin, Heidelberg: Springer Berlin Heidelberg, 2004. http://dx.doi.org/10.1007/978-3-642-18840-4_6.

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"Quantification of Recent Thymic Emigrants: T-Cell-Receptor Excision Circles." In Manual of Molecular and Clinical Laboratory Immunology, 7th Edition, 291–95. American Society of Microbiology, 2006. http://dx.doi.org/10.1128/9781555815905.ch33.

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