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Dissertations / Theses on the topic 'T cell transfer'

Author: Grafiati

Published: 9 March 2023

Last updated: 31 July 2025

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1

Sommermeyer, Daniel. "Generation of dual T cell receptor (TCR) T cells by TCR gene transfer for adoptive T cell therapy." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2010. http://dx.doi.org/10.18452/16051.

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Die Herstellung von T-Zellen mit definierten Spezifitäten durch den Transfer von T-Zellrezeptor (TCR) Genen ist eine effiziente Methode, um Zellen für eine Immuntherapie bereitzustellen. Eine besondere Herausforderung ist dabei, ein ausreichend hohes Expressionsniveau des therapeutischen TCR zu erreichen. Da T-Zellen mit einem zusätzlichen TCR ausgestattet werden, entsteht eine Konkurrenzsituation zwischen dem therapeutischen und dem endogenen TCR. Bevor diese Arbeit begonnen wurde war nicht bekannt, welche TCR nach einem Gen-Transfer exprimiert werden. Daher haben wir Modelle etabliert, in de

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2

Wright, G. P. "Generation of antigen-specific regulatory T cells by T cell receptor gene transfer." Thesis, University College London (University of London), 2009. http://discovery.ucl.ac.uk/18952/.

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Regulatory T cells (Tregs) have shown considerable potential in the treatment of murine models of immuno-pathology. Whilst poly-clonal Tregs are able to suppress immuno-pathology in a number of models, the superiority of Ag-specific Treg treatment has been demonstrated using Tregs from T cell receptor (TCR)- transgenic animals. Translation of these promising results to the clinic has been hampered by difficulties in isolating or enriching the rare Ag-specific Tregs from the polyclonal population. Here I describe two distinct approaches to generate Ag-specific T cells with regulatory ability: f

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3

Bracq, Lucie. "Analysis of HIV-1 cell-to-cell transfer to macrophages." Thesis, Sorbonne Paris Cité, 2017. http://www.theses.fr/2017USPCB063/document.

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Les macrophages sont une cible particulièrement importante de l’infection par le VIH-1 et jouent un rôle crucial dans la physiopathologie de l’infection. Lorsqu’ils sont infectés, leur capacité de survie dans les tissus leur permet de jouer un rôle essentiel dans la dissémination virale et l’établissement de réservoirs viraux au niveau des différents territoires tissulaires. In vitro, les étapes précoces et tardives du cycle de réplication virale dans les macrophages ont été analysées dans le cadre de l’infection par des virus libres. Cependant, les modalités d’infection des macrophages lors d

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4

Böhm, Stefanie [Verfasser], and Lars [Akademischer Betreuer] Nitschke. "Adoptive T-cell-receptor transfer to examine human T-cell immunology in vitro / Stefanie Böhm. Betreuer: Lars Nitschke." Erlangen : Universitätsbibliothek der Universität Erlangen-Nürnberg, 2013. http://d-nb.info/1033688193/34.

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5

Chakupurakal, Geothy. "Preclinical studies of adenovirus-specific T-cells for adoptive transfer to haemopoietic stem cell transplant recipients." Thesis, University of Birmingham, 2011. http://etheses.bham.ac.uk//id/eprint/2883/.

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Allogeneic stem cell transplantation (SCT) is the only curative treatment option for many haematological malignancies. Adenovirus (Ad) infections are a significant cause of morbidity and mortality post SCT. Lack of effective anti-viral treatment for Ad disease has led to the development of adoptive immunotherapy of Ad-specific T-cells as a promising therapeutic option for patients in this setting. The aim of this project was to establish preclinical criteria for the development of a clinical trial comparing two T-cell enrichment methods- multimer selection and cytokine secretion selection to e

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6

Carluccio, S. "GENERATION OF TUMOR-SPECIFIC CYTOTOXIC T-LYMPHOCYTES FROM PEROPHERAL BLOOD OF COLORECTAL CANCER PATIENTS FOR ADOPTIVE T-CELL TRANSFER." Doctoral thesis, Università degli Studi di Milano, 2014. http://hdl.handle.net/2434/231155.

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Colorectal cancer (CRC) is the third most common cancer worldwide and the fourth most common cause of death in the developed Western countries. Adoptive T-cell transfer (ACT) refers to an immunotherapeutic approach in which anti-tumor T lymphocytes, usually the tumor infiltrating lymphocytes (TIL), are identified, grown ex vivo and then re-infused into the cancer patient. ACT of EBV-specific T-cell lines and T Cytotoxic Lymphocytes (CTLs) for the therapy of EBV-induced lymphomas is the best demonstration of clinically efficacious ACT, but there are many evidences also for leukemia and multi

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7

Gräf, Patricia [Verfasser]. "Serial transfer of single cell-derived immunocompetence reveals stemness of CD8+ central memory T cells / Patricia Gräf." München : Verlag Dr. Hut, 2015. http://d-nb.info/1070124389/34.

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8

Akhter, Waseem. "Le rôle du transfert de mitochondries des cellules stromales mésenchymateuses (CSM) dans la suppression des réponses des cellules T CD4+ et CD8+." Thesis, Université de Montpellier (2022-….), 2022. http://www.theses.fr/2022UMONT011.

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Les lymphocytes T cytotoxiques CD8+ (LTC) et les cellules T helper CD4+ sont des effecteurs clés dans les maladies auto-immunes, les maladies du greffon contre l'hôte et le rejet de greffe. Les cellules stromales mésenchymateuses (CSM) sont des cellules multipotentes auto-renouvelables qui possèdent des propriétés de réparation tissulaire et d'immunomodulation. En raison de leur capacité à réprimer les réponses immunitaires pathogènes, elles présentent un potentiel thérapeutique pour le traitement des maladies à médiation immunitaire. Les CSMs ont la capacité unique d'exporter leurs propres mi

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9

Uhlig, Holm H. "Intestinal bacterial flora and the inflammatory immune response in the T cell transfer model of colitis." Thesis, University of Oxford, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.403771.

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10

Petschenka, Jutta [Verfasser]. "Safety and therapeutic efficacy of adoptive p53-specific T cell antigen receptor (TCR) gene transfer / Jutta Petschenka." Mainz : Universitätsbibliothek Mainz, 2014. http://d-nb.info/1052080685/34.

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11

Weigand, Luise [Verfasser], Heinrich H. D. [Akademischer Betreuer] Meyer, and Angela [Akademischer Betreuer] Krackhardt. "Characterization of human MHC II-restricted T cell receptors with reactivity against B cells and tumor cells for therapeutic application in the context of adoptive T cell transfer of transgenic CD4 T cells / Luise Weigand. Gutachter: Angela Krackhardt ; Heinrich H. D. Meyer. Betreuer: Heinrich H. D. Meyer." München : Universitätsbibliothek der TU München, 2011. http://d-nb.info/1016727798/34.

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12

Hiraragi, Hajime. "Study of lentiviral vector for in utero gene transfer and functional analysis of human T-lymphotropic virus type p13(II)." Connect to resource, 2005. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1116532636.

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Thesis (Ph. D.)--Ohio State University, 2005.<br>Title from first page of PDF file. Document formatted into pages; contains xvii, 230 p.; also includes graphics. Includes bibliographical references (p. 200-230). Available online via OhioLINK's ETD Center

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Nihei, Jorge Sadao. "Estudo da migração de células T NK1.1+ no músculo estriado, durante a infecção experímental pelo Trypanosoma Cruzi em animais desprovidos de linfócitos B funcionais." reponame:Repositório Institucional da FIOCRUZ, 2005. https://www.arca.fiocruz.br/handle/icict/5907.

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Submitted by Ana Maria Fiscina Sampaio (fiscina@bahia.fiocruz.br) on 2012-11-29T20:46:26Z No. of bitstreams: 1 Jorge Sadao Nihei Estudo da migracao... 2005.pdf: 58998863 bytes, checksum: 723e59711f41bac163f89f23858f2c34 (MD5)<br>Made available in DSpace on 2012-11-29T20:46:26Z (GMT). No. of bitstreams: 1 Jorge Sadao Nihei Estudo da migracao... 2005.pdf: 58998863 bytes, checksum: 723e59711f41bac163f89f23858f2c34 (MD5) Previous issue date: 2005<br>Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, Brasil<br>Foi anteriormente demonstrado que as células NK (Natural Ki

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Norris, Paula Suzanne. "Retrovirus-mediated transfer of wild-type p53 and p16INK4a suppresses cell growth in a mouse model for T-cell acute lymphoblastic leukemia via independent mechanisms /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 1998. http://wwwlib.umi.com/cr/ucsd/fullcit?p9904819.

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15

BLYTH, Emily Margaret. "The reconstitution of cellular immunity via adoptive transfer of multi-pathogen specific donor-derived T cells in recipients of allogeneic haemopoietic stem cell transplantation." Thesis, The University of Sydney, 2013. http://hdl.handle.net/2123/9478.

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Allogeneic haemopoietic stem cell transplantation is the only curative therapy for a number of haematological diseases. Infection remains a leading cause of non-relapse mortality due to impaired recipient immunity. The reconstitution of cellular immunity via adoptive T cell transfer is a promising way to address this problem. Establishment of feasibility, safety and efficacy via clinical translation and expansion of the repertoire of pathogens targeted by adoptive T cell transfer strategies are the central goals of this thesis. Chapter 2 describes a clinical trial of 50 patients treated with

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16

Shippy, Daniel. "Effects of Adoptive Transfer of Beta-Amyloid Sensitive Immune Cells in a Mouse Model for Alzheimer’s Disease." Scholar Commons, 2005. https://scholarcommons.usf.edu/etd/861.

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One major therapeutic target for preventing and treating Alzheimer's Disease (AD) is removal of excess β-amyloid (Aβ) from the brain. Both active and passive immunotherapies targeting Aβ have proven effective in reducing brain Aβ levels and improving cognitive function in mouse transgenic models of AD. However, these approaches can induce adverse neuropathologic effects and immunologic over-activation. Indeed, clinical trials of active Aβ immunotherapy in AD patients were halted due to development of meningoencephalitis, apparently resulting from wide-spread neuroinflammation. Here we show tha

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17

Proust, Alizé. "Etude du transfert du VIH-1 des cellules présentatrices d'antigènes aux lymphocytes T CD4 primaires et inhibition par les anticorps neutralisants." Thesis, Strasbourg, 2013. http://www.theses.fr/2013STRAJ107/document.

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Les cellules présentatrices d'antigènes (APCs) présentes dans les muqueuses comptent parmi les première cibles du VIH-1 et participent à sa dissémination dans l'organisme. Durant ma thèse, j'ai étudié le transfert du VIH des macrophages (Mφ) et des cellules dendritiques (DCs) aux lymphocytes T. J'ai montré que ces APCs transfèrent efficacement le virus aux lymphocytes par le biais de différents mécanismes: transfert direct en trans dans les coculture Mφ/T, et transfert en cis (suite à la production de nouveaux virions) dans les DCs/T. Ces deux modes de transfert sont inhibés par les anticorps

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18

Singh, Ogesh. "Regulatory T cell diversity analysis and a gene transfer approach to cellular immunotherapy in a murine model of type one diabetes." Thesis, Royal Veterinary College (University of London), 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.522749.

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19

Edes, Inan. "Targeted transduction of T cell subsets for immunotherapy of cancer and infectious disease." Doctoral thesis, Humboldt-Universität zu Berlin, Lebenswissenschaftliche Fakultät, 2016. http://dx.doi.org/10.18452/17669.

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Das Ziel der vorliegenden Arbeit bestand darin, ein Vektorsystem zu entwickeln, dass den simultanen Transfer verschiedener Transgene in CD8+ und CD4+ T-Zellen und dadurch die Herstellung eines immunotherapeutischen T-Zell-Produkts ermöglicht, welches aus zwei unterschiedlich modifizierten T-Zell-Subtypen besteht. Im ersten Teil der Arbeit wurde die Targeting-Technologie von lentiviralen auf γ-retrovirale Vektoren übertragen. Anschließend wird die Herstellung von Vektoren beschrieben, die spezifisch für murines CD4 oder CD8 sind. Deren Spezifität wurde zum einen durch die exklusive Expressio

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Bôle-Richard, Elodie. "Développement d'outils innovants et sécurisés de thérapie cellulaire et génique basés sur la reprogrammation de lymphocytes T dans un contexte d'immunothérapie anti-tumorale." Thesis, Besançon, 2016. http://www.theses.fr/2016BESA3001/document.

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La thérapie cellulaire est basée sur l'administration de cellules immunocompétentes dans le but d'induire une réponse thérapeutique. Le transfert de gène est un moyen d'optimiser et de sécuriser la thérapie cellulaire. Récemment, plusieurs essais cliniques d'immunothérapie ont montré l'efficacité de lymphocytes T reprogrammés pour le traitement des cancers. De plus, le transfert de gène « suicide » permet de sécuriser les effecteurs immunitaires utilisés en thérapie cellulaire. Cependant, les capacités des cellules pourraient encore être améliorées par l'expression de cytokines et de récepteur

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21

Mak'Anyengo, Rachel [Verfasser], and Christian [Akademischer Betreuer] Bauer. "Role of the NIrp3 inflammasome in regulation of the tolerogenic function of CD103+ dendritic cells in CD4+CD45RbHigh T cell transfer colitis and in steady state / Rachel Mak'Anyengo ; Betreuer: Christian Bauer." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2017. http://d-nb.info/1165503905/34.

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22

Schirrmann, Thomas. "Tumorspezifische Targeting der humanen natürlichen Killerzellinie YT durch Gentransfer chimärer Immunglobulin-T-Zellrezeptoren." Doctoral thesis, Humboldt-Universität zu Berlin, Medizinische Fakultät - Universitätsklinikum Charité, 2005. http://dx.doi.org/10.18452/15246.

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Die spezifische adoptive Immuntherapie ist ein hoffnungsvoller Ansatz zur Behandlung von Tumoren. Die aufwendige individuelle Bereitstellung primärer Effektorlymphozyten könnte durch den Einsatz etablierter tumorantigenspezifischer Effektorzellinien vermieden werden. In dieser Arbeit wurde untersucht, ob sich ein Tumortargeting der humanen Natürlichen Killer-(NK)-Zellinie YT durch den Gentransfer chimärer Immunglobulin-T-Zellrezeptoren (cIgTCRs) erreichen läßt. Die cIgTCR-Konstrukte wurden aus single-chain-Fv-Fragmenten (scFv), dem IgG1-Fc-Teil und der CD3-Zeta-Signalkette erzeugt. Die scFv-Fr

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23

MERCURI, ELISABETTA. "PRECLINICAL MODELING HIGHLIGHTS THE THERAPEUTIC POTENTIAL OF THE ADOPTIVE TRANSPLANT OF GENE CORRECTED T CELLS IN X-LINKED HYPER-IGM IMMUNODEFICIENCY." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2020. http://hdl.handle.net/10281/263922.

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La terapia genica di cellule staminali ematopoietiche (HSC) ha prodotto benefici clinici in diversi pazienti affetti da una varietà di malattie genetiche. Tuttavia, l’uso di vettori che si integrano nel genoma in modo semi-casuale pone il rischio di mutagenesi inserzionale e di una espressione del transgene ectopica/non regolata. Quest’ultimo problema è particolarmente rilevante quando si trattano geni strettamente regolati attivi sulla proliferazione cellulare, come il gene CD40LG, la cui espressione sulle cellule T attivate porta all’attivazione contatto-dipendente delle cellule B, alla loro

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ANNONI, ANDREA. "Strategies for tolerance induction to gene therapy derived products." Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2009. http://hdl.handle.net/2108/763.

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I vettori lentivirali (LV) rappresentano una concreta realtà per lo sviluppo di protocolli di terapia genica. I LV, infatti, hanno la capacità di trasdurre ed integrare stabilmente il proprio genoma anche in cellule che non sono in attivo stato di replicazione. Tuttavia, uno dei maggiori ostacoli al successo degli approcci di terapia genica che prevedono l’utilizzo di vettori virali è rappresentato dalla risposta immune innata ed adattativa da essi indotta. Le risposte immuni cellulo-mediate ed anticorpali dirette verso antigeni associati alle particelle virali e alla proteina derivante dal tr

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Cobbold, Mark. "Direct selection and adoptive transfer of cytomegalovirus-specific cytotoxic T cells." Thesis, University of Birmingham, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.433688.

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Pospori, C. "WT1 TCR gene transfer into haematopoietic stem cells : in vivo functional analysis of WT1-specific T cells." Thesis, University College London (University of London), 2012. http://discovery.ucl.ac.uk/1369532/.

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The Wilms tumour antigen is a promising target for T cell-based tumour immunotherapies. Vaccines against WT1 peptides tested in cancer patients showed immunological and molecular responses. However, the clinical responses observed were partial and it is currently not known whether physiological levels of WT1 expression in some healthy tissues results in the deletion or tolerance induction of WT1-specific T cells. In this PhD project, TCR gene transfer into purified haematopoietic stem cells (HSCs) was used to study the thymic development of WT1-specific T cells and their fate in the periphery.

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Klysz, Dorota. "Impact of lymphopenia-inducing regimens and energetic resources on the fate of adoptively transferred T cells." Thesis, Montpellier 2, 2014. http://www.theses.fr/2014MON20184/document.

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Les thérapies anti-tumorales se sont considérablement améliorées au cours de la dernière décennie. Toutefois, les traitements utilisés actuellement rencontrent d'importantes limitations, notamment dans le cas de cancers métastatiques, révélant l'urgence de développer de nouvelles approches. Ainsi, l'immunothérapie par transfert adoptif de cellules T représente une approche innovante particulièrement prometteuse. Son principe s'appuie sur l'injection de cellules T autologues spécifiques d'antigènes tumoraux, préalablement manipulées et amplifiées ex vivo, chez des patients rendus lymphopéniques

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Ghenassia, Alexandre. "Induction de réponses mémoires lymphocytaires T CD8 et protection vaccinale après transfert de gènes par le vecteur AAV recombinant." Thesis, Sorbonne Paris Cité, 2015. http://www.theses.fr/2015PA05T032/document.

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La mémoire immunologique est le mécanisme biologique fondamental à la base du développement de la vaccination. La compréhension de ce mécanisme ainsi que de ses interactions avec les différents acteurs du système immunitaire a permis l’élaboration de vaccins qui sont aujourd’hui les garants d’une protection accrue face à l’émergence de maladies infectieuses potentiellement mortelles. La voie d’injection et le mode de transfert de ces vaccins sont des paramètres majeurs à prendre en considération car ils définissent une modulation des réponses immunitaires et de leurs spécificités d’action. De

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Balducci, Estelle. "Microvésicules et microARNs : rôle dans le transfert d'informations biologiques entre les lymphocytes T CD4 et l'endothélium au cours de l'infection par le VIH-1." Thesis, Aix-Marseille, 2017. http://www.theses.fr/2017AIXM0423.

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Le virus de l’immunodéficience humaine de type 1 (VIH-1) induit une activation généralisée des réponses de l'hôte impliquant les lymphocytes T mais aussi les cellules du microenvironnement comme les cellules endothéliales. Les microvésicules (MV) sont des vésicules extracellulaires impliquées dans la communication intercellulaire décrites comme des vecteurs de microARNs (miARNs). Dans ce travail, nous avons émis l'hypothèse que l'infection par le VIH-1 induit l'expression de miARNs dans les lymphocytes T CD4 qui peuvent être vectorisés par les MV et transférés de manière paracrine aux CE. Ces

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Gagnepain, Anaïs. "Évaluation de nouveaux pseudotypes de vecteurs lentiviraux pour le transfert de gènes dans les cellules hématopoiétiques." Thesis, Lyon, École normale supérieure, 2014. http://www.theses.fr/2014ENSL0939/document.

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Le transfert de gènes dans les cellules souches hématopoïétiques par des vecteurs lentiviraux s’inscrit dans les protocoles actuels de traitement par thérapie génique de plusieurs maladies monogéniques (B-thalassémie, Adrénoleucodystrophie, SCID…). De même, le transfert de gènes dans les lymphocytes T et B ouvre des perspectives tant au niveau de la thérapie génique que pour l’immunothérapie. Nous avons mis au point des vecteurs lentiviraux pseudotypés par des glycoprotéines chimérique (BaEV/TR) et mutante (BaEVRLess) du rétrovirus endogène de babouin. Nous avons montré que ces nouveaux vecteu

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Kozlov, Andriy. "T-type Ca channels as pathways of Ca2+ entry into the cell. : Role of ion-channel interactions in channel gating." Université Louis Pasteur (Strasbourg) (1971-2008), 2001. http://www.theses.fr/2001STR13186.

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Zeng, Yi [Verfasser], and Stefan [Akademischer Betreuer] Endres. "Gene expression profiles of T cells after adoptive transfer in a mouse model of pancreatic carcinoma / Yi Zeng ; Betreuer: Stefan Endres." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2017. http://d-nb.info/1126407313/34.

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Cabrera, Aulestia Francisco Javier. "Treating Cellular Stress and Damage : Use of Healthy Mitochondria Isolated from Donor Cells in the Artificial Mitochondria Transfer / Transplant (Amt/T) to Repair Mitochondrial Disfunction in Differentiated (Peripheral Blood Mononuclear Cells) and Germinal Cells (Oocytes)." Thesis, Montpellier, 2019. http://www.theses.fr/2019MONTT073.

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Selon la théorie endosymbiotique, la mitochondrie est un organite dérivé d'une ancienne alpha-protéobactérie qui développa une symbiose avec un ancêtre eucaryote. L'ADN mitochondrial (ADNmt) existe dans des centaines à des milliers d'exemplaires dans chaque cellule et code pour 13 protéines structurelles qui sont des sous-unités de la chaîne respiratoire. Les mitochondries génèrent de l'énergie pour les processus cellulaires en produisant de l'ATP par phosphorylation oxydative. Ils contrôlent également d’autres processus tels que la synthèse de nucléotide et d’hème, l’équilibre rédox, le métab

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Rothe, Katherina. "Einfluss CD4+CD25+ regulatorischer T-Zellen auf die hämatopoetische Rekonstitution nach syngener und allogener Stammzelltransplantation in einem dreifach transgenen Mausmodell." Doctoral thesis, Universitätsbibliothek Leipzig, 2011. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-68783.

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Regulatorische CD4+CD25+ T-Zellen (Tregs) stellen eine kleine Zellpopulation dar (1-5% der peripheren Blutzellen), die hauptsächlich für die Regulierung von Immunreaktionen verantwortlich ist. In der vorliegenden Arbeit wurden diese Zellen gemeinsam mit Stammzellen syngen und allogen kotransplantiert, um ihren Effekt auf das Anwachsen der Spenderzellen und die Rekonstitution der Hämatopoese nach Ganzkörperbestrahlung zu untersuchen. Es wurden humanisierte dreifach transgene Empfängermäuse (C57Bl/6-TTG) verwendet (human CD4+, murin CD4-, human HLA-DR+), wodurch sowohl bei syngener als auch bei

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Monjezi, Razieh [Verfasser], and Michael [Gutachter] Hudecek. "Engineering of chimeric antigen receptor T cells with enhanced therapeutic index in cancer immunotherapy using non-viral gene transfer and genome editing / Razieh Monjezi ; Gutachter: Michael Hudecek." Würzburg : Universität Würzburg, 2018. http://d-nb.info/1162062231/34.

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Perche, Federico. "Transfert d'ARNm par des lipopolyplexes et vaccination antimélanome : ciblage des cellules dendritiques à l'aide de lipopolyplexes mannosylés." Phd thesis, Université d'Orléans, 2010. http://tel.archives-ouvertes.fr/tel-00665118.

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Précédemment, il a été démontré au laboratoire qu'une vaccination des souris avec des lipopolyplexes (LPR) contenant l'ARNm de l'antigène de mélanome MART1 permet d'induire la formation de lymphocytes T cytotoxiques spécifiques et de retarder le développement de mélanomes B16F10 et de métastases pulmonaires. Les LPR sont des complexes ternaires constitués d'ARNm, d'un polymère cationique histidylé et de liposomes cationiques histidylés. L'objectif de ma thèse était d'améliorer cette vaccination antitumorale en développant de nouveaux liposomes capables de cibler les cellules dendritiques (DC).

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Kuruc, Jiří. "Podpora kvalitativních požadavků služeb v rádiových přístupových sítích vysokorychlostních variant mobilních sítí." Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2009. http://www.nusl.cz/ntk/nusl-218103.

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The work deals with the developmental stages (Releases) of the third generation UMTS net-works. It explains a partial improvement from Release 99 to Release 5 and Release 6 to im-prove the quality parameters of a mobile data transmission. In the practical part, there are measured qualitative parameters of the third generation networks that are available in the Czech Republic: UMTS, HSDPA, CDMA 1xEV-DO Rev.0 and Rev.A and UMTS-TDD. The measurements give reasonably achievable data rates in both directions (downlink & uplunk), a response time, quality of VoIP calls, a dispersion, a data-loss and

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Lederle, Alexandre. "Infection des cellules dendritiques plasmacytoïdes par le VIH : mécanisme d'inhibition par les anticorps et étude des modifications fonctionnelles." Phd thesis, Université de Strasbourg, 2012. http://tel.archives-ouvertes.fr/tel-00766677.

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Les cellules dendritiques plasmacytoïdes (pDC) sont infectées par le VIH-1 et la diminution de leur nombre dans la circulation sanguine est corrélée avec la virémie des patients. Au cours de mes travaux de thèse, nous avons montré que les anticorps neutralisants (AcN) spécifiques du VIH-1 inhibent l'infection des pDC par des isolats primaires de VIH-1. Contrairement aux mDC, le mécanisme d'inhibition de l'infection des pDC est indépendant du RFcγII présent à leur surface. En parallèle, nos résultats indiquent que les pDC produisent de l'interféron-α et d'autres cytokines et chimiokines en répo

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Aganj, Ehsan. "Multi-view Reconstruction and Texturing=Reconstruction multi-vues et texturation." Phd thesis, Ecole des Ponts ParisTech, 2009. http://pastel.archives-ouvertes.fr/pastel-00517742.

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Dans cette thèse, nous étudions les problèmes de reconstruction statique et dynamique à partir de vues multiples et texturation, en s'appuyant sur des applications réelles et pratiques. Nous proposons trois méthodes de reconstruction destinées à l'estimation d'une représentation d'une scène statique/dynamique à partir d'un ensemble d'images/vidéos. Nous considérons ensuite le problème de texturation multi-vues en se concentrant sur la qualité visuelle de rendu..

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Terschlüsen, Joachim A. "Constructing and Commissioning HELIOS – A High Harmonic Generation Source for Pump-Probe Measurements with sub 50 fs Temporal Resolution : The Development of Experimental Equipment for Extreme Ultraviolet Spectroscopy." Doctoral thesis, Uppsala universitet, Molekyl- och kondenserade materiens fysik, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-281298.

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This thesis presents HELIOS, an in-house laboratory for time-resolved pump-probe spectroscopy with extreme-ultraviolet (XUV) probe radiation. A wide span of pump wavelengths can be generated using commercial laser equipment while XUV probe radiation is generated via a high harmonic generation process in a noble gas delivering probe photons with energies between 20 eV and 72 eV. The XUV beam path features a time-preserving monochromator and was constructed and built in-house. HELIOS features an overall time resolution of about 50 fs when using 800 nm pump and 41 eV probe photons. An energy reso

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Sommermeyer, Daniel [Verfasser]. "Generation of dual T cell receptor (TCR) T cells by TCR gene transfer for adoptive T cell therapy / Daniel Sommermeyer." 2010. http://d-nb.info/1002067073/34.

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Wang, Fu-Hwei, and 王復輝. "Gene transfer into antigen-specific T cells induced by dendritic cell stimulation." Thesis, 2001. http://ndltd.ncl.edu.tw/handle/23981444690757150066.

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碩士<br>東吳大學<br>微生物學系<br>89<br>The infusion of antigen-specific T lymphocytes is a potential therapy against certain cancers and viral diseases. To increase their effectiveness, we examined whether the combined use of retroviral vector, which only infects dividing cells, and in vitro sensitization of T cells with antigen-loaded dendritic cells (DCs) could selectively modify antigen- specific T cells, and whether the transfer of bcl-2 gene could enhance the survival of antigen-specific T cells. The surface and core antigens of hepatitis B virus (HBV) were used as model antigens. DCs transfected w

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Seehar, Mehwish. "Adoptive cell transfer: examining the potential of a T cell-mediated therapy for metastatic melanoma." Thesis, 2016. https://hdl.handle.net/2144/19481.

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Adoptive cell transfer techniques identify and isolate patient anti-tumor lymphocytes in vitro followed by ex vivo expansion of these tumor specific T cells. Identification and isolation of lymphocytes from patient tumors allows for the selection of anti-tumor lymphocytes that are highly specific for individual tumor antigens. Furthermore, recombinant technology allows for engineering of chimeric antigen receptors (CARs) which allow these T cells to target multiple tumor antigens. Techniques involving ex vivo growth lead to a 1,000- to 5,000-fold increase in numbers of lymphocytes. Cultured ly

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Jaleco, Sara Monteiro Primo. "Gene transfer and homeostasis of neonatal and adult T cell subsets." Doctoral thesis, 2004. http://hdl.handle.net/10316/10151.

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Tese de doutoramento em Biologia (Biologia Celular) apresentada à Fac. de Ciências e Tecnologia de Coimbra<br>A utilização de células T geneticamente modificadas representa uma poderosa esperança para o tratamento de diversas doenças do foro hematológico. Os vectores virais derivados de ‘Murine Leukemia Virus’ (MuLV) podem ser utilizados para introduzir, de forma estável, material genético, uma vez que integram o genoma do hospedeiro. Contudo, o uso destes vectores é limitado às células em divisão; como a maioria dos linfócitos T se encontra em estado quiescente, estas células têm de ser activ

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Vávrová, Kateřina. "Adoptivní transfer tumor-specifických lymfocytů v imunoterapii nádorových onemocnění." Doctoral thesis, 2020. http://www.nusl.cz/ntk/nusl-435278.

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Prostate cancer is the second leading cause of cancer death in men in Europe and the US. In the context of previous preclinical experiments and clinical studies there are certain assumptions predicating successful application of immunotherapy in the treatment of patients with prostate cancer. Promising results have been achieved by a combination of different treatment modalities which provide a synergistic antitumor effect. One of these combinatorial options is the use of antitumor vaccines and adoptive T cell transfer. The topic of this thesis is to provide a fresh insight into the past and c

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Lin, Regina. "Targeting T Cells for the Immune-Modulation of Human Diseases." Diss., 2015. http://hdl.handle.net/10161/9824.

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<p>Dysregulated inflammation underlies the pathogenesis of a myriad of human diseases ranging from cancer to autoimmunity. As coordinators, executers and sentinels of host immunity, T cells represent a compelling target population for immune-modulation. In fact, the antigen-specificity, cytotoxicity and promise of long-lived of immune-protection make T cells ideal vehicles for cancer immunotherapy. Interventions for autoimmune disorders, on the other hand, aim to dampen T cell-mediated inflammation and promote their regulatory functions. Although significant strides have been made in targeting

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Zysk, Aneta. "Adoptive transfer of ex vivo expanded gamma delta T cells targeting osteolytic cancer in the bone." Thesis, 2017. http://hdl.handle.net/2440/119272.

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Bone metastases occur in more than 75% of patients with advanced breast cancer. Cancer in bone is associated with bone destruction and is responsible for high levels of morbidity and mortality but is notoriously difficult to treat. Bone destruction is also the primary cause of morbidity in patients with primary bone cancer, such as osteosarcoma, with metastatic spread to the lungs correlating with poor survival. Therefore, clearly new therapies are desperately required to target cancers in the bone. This study explored the therapeutic potential of gamma delta (Vγ9Vδ2) T cell based adoptive tra

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Gary, Regina [Verfasser]. "Characterization and functional analysis of the transfer of cell components from human antigen-presenting cells onto T cells via antigen-specific trogocytosis / vorgelegt von Regina Gary." 2010. http://d-nb.info/101213069X/34.

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Monjezi, Razieh. "Engineering of chimeric antigen receptor T cells with enhanced therapeutic index in cancer immunotherapy using non-viral gene transfer and genome editing." Doctoral thesis, 2018. https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-152521.

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The advances in genetic engineering have enabled us to confer T cells new desired functions or delete their specific undesired endogenous properties for improving their antitumor function. Due to their efficient gene delivery, viral vectors have been successfully used in T-cell engineering to provide gene transfer medicinal products for the treatment of human disease. One example is adoptive cell therapy with T cells that were genetically modified with gamma-retroviral and lentiviral (LV) delivery vectors to express a CD19-specific chimeric antigen receptor (CAR) for cancer treatment. This the

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Wang, Ting. "Transfer of intracellular HIV Nef to endothelium causes endothelial dysfunction." Thesis, 2014. http://hdl.handle.net/1805/5584.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>With effective antiretroviral therapy (ART), cardiovascular diseases (CVD), are emerging as a major cause of morbidity and death in the aging population with HIV infection. Although this increase in CVD could be partially explained by the toxic effects of combined anti-retroviral therapy (ART), more recently, HIV infection has emerged as an independent risk factor for CVD. However, it is unclear how HIV can contribute to CVD in patients on ART, when viral titers are low or non-detectable. Here, we provide several lines of evidence th

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