Relevant bibliographies by topics / T cells Actins

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers

Academic literature on the topic 'T cells Actins'

Author: Grafiati
Published: 4 June 2021
Last updated: 4 February 2022

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Journal articles on the topic "T cells Actins"

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Guenal, I., Y. Risler, and B. Mignotte. "Down-regulation of actin genes precedes microfilament network disruption and actin cleavage during p53-mediated apoptosis." Journal of Cell Science 110, no. 4 (1997): 489–95. http://dx.doi.org/10.1242/jcs.110.4.489.

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Inactivation of Simian Virus 40 large T antigen, in cells immortalized with conditional mutants, leads to activation of p53 and apoptosis. We used the mRNA differential display method to identify genes differentially expressed during this process. We found that steady-state levels of mRNA for cytoplasmic actins decreased early during apoptosis. We also showed that, although the steady-state level of the corresponding proteins is not profoundly affected, they are substrates for an interleukin 1-beta converting enzyme (ICE)-like protease activated during the process. However, only a very small f
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Jahn, L., J. Sadoshima, A. Greene, C. Parker, K. G. Morgan, and S. Izumo. "Conditional differentiation of heart- and smooth muscle-derived cells transformed by a temperature-sensitive mutant of SV40 T antigen." Journal of Cell Science 109, no. 2 (1996): 397–407. http://dx.doi.org/10.1242/jcs.109.2.397.

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To create muscle cell lines that conditionally differentiate in vitro we introduced a temperature-sensitive SV40 T antigen by retroviral infection into rat aortic smooth muscle cells (SMCs) and neonatal heart-derived cells. After G418 selection cell lines isolated were characterized at permissive (33 degrees C) and non-permissive (39 degrees C) temperatures. [3H]Thymidine uptake showed tht progression through the cell cycle is greatly reduced at 39 degrees C. Cytoskeletal proteins, such as actins and vimentin did not change significantly after temperature shift, while the number of desmin-posi
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Lührmann, Anja, Jürgen Thölke, Ingrid Behn, Jens Schumann, Gisa Tiegs, and Sunna Hauschildt. "Immunomodulating Properties of the Antibiotic Novobiocin in Human Monocytes." Antimicrobial Agents and Chemotherapy 42, no. 8 (1998): 1911–16. http://dx.doi.org/10.1128/aac.42.8.1911.

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ABSTRACT We show that the coumeromycin antibiotic novobiocin, a potent inhibitor of ADP ribosylation, prevents lipopolysaccharide (LPS)-induced tumor necrosis factor alpha (TNF-α), interleukin-1 (IL-1), IL-6, and IL-10 secretion in human peripheral blood mononuclear cells. It shares these cytokine-suppressing properties with other inhibitors of ADP ribosylation. We found that novobiocin prevents TNF-α production by inhibiting translation of the TNF-α mRNA. Elevated TNF-α levels in mice treated withd-galactosamine (GalN)-LPS or GalN-TNF were not reduced by novobiocin; however, the drug exhibite
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Tatic, Vujadin, Vladimir Kanjuh, Sasa Rafajlovski, Kristina Kostic, and Dusan Suscevic. "Importance of inflammation in arteriosclerotic plaque destabilization and rupture." Vojnosanitetski pregled 62, no. 9 (2005): 649–53. http://dx.doi.org/10.2298/vsp0509649t.

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Introduction. Although Rudolf Virchow considered arteriosclerosis an inflammatory disease in his book Cellular Pathology published in 1858, the opinion that it was a degenerative arterial disease as a civilization disease prevailed. Nowadays, a great attention has been paid to the inflammatory process in the pathogenesis of arteriosclerosis and particularly in the destabilization and rupture of plaque. Aim. To find out whether T and B lymphocytes, lipid macrophages, vascular smooth muscle and mast cells as well as plaque destabilization and rupture are present in ruptured arteriosclerotic plaq
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Fogg, Christiana N. "T cells need nuclear F-actin." Science 363, no. 6423 (2019): 137.22–139. http://dx.doi.org/10.1126/science.363.6423.137-v.

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Corre, Isabelle, Manuel Gomez, Susina Vielkind, and Doreen A. Cantrell. "Analysis of Thymocyte Development Reveals That the Gtpase Rhoa Is a Positive Regulator of T Cell Receptor Responses in Vivo." Journal of Experimental Medicine 194, no. 7 (2001): 903–14. http://dx.doi.org/10.1084/jem.194.7.903.

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Loss of function of the guanine nucleotide binding protein RhoA blocks pre-T cell differentiation and survival indicating that this GTPase is a critical signaling molecule during early thymocyte development. Previous work has shown that the Rho family GTPase Rac-1 can initiate changes in actin dynamics necessary and sufficient for pre-T cell development. The present data now show that Rac-1 actions in pre-T cells require Rho function but that RhoA cannot substitute for Rac-1 and induce the actin cytoskeletal changes necessary for pre-T cell development. Activation of Rho is thus not sufficient
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Pacifici, Roberto. "T Cells Involvement in PTH Anabolic Actions." Bone 46 (March 2010): S12. http://dx.doi.org/10.1016/j.bone.2010.01.014.

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Liu, Y., N. V. Belkina, and S. Shaw. "HIV Infection of T Cells: Actin-in and Actin-out." Science Signaling 2, no. 66 (2009): pe23. http://dx.doi.org/10.1126/scisignal.266pe23.

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Chow, K. L., and R. J. Schwartz. "A combination of closely associated positive and negative cis-acting promoter elements regulates transcription of the skeletal alpha-actin gene." Molecular and Cellular Biology 10, no. 2 (1990): 528–38. http://dx.doi.org/10.1128/mcb.10.2.528.

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The chicken skeletal alpha-actin gene promoter region provides at least a 75-fold-greater transcriptional activity in muscle cells than in fibroblasts. The cis-acting sequences required for cell type-restricted expression within this 200-base-pair (bp) region were elucidated by chloramphenicol acetyltransferase assays of site-directed Bg/II linker-scanning mutations transiently transfected into primary cultures. Four positive cis-acting elements were identified and are required for efficient transcriptional activity in myogenic cells. These elements, conserved across vertebrate evolution, incl
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Chow, K. L., and R. J. Schwartz. "A combination of closely associated positive and negative cis-acting promoter elements regulates transcription of the skeletal alpha-actin gene." Molecular and Cellular Biology 10, no. 2 (1990): 528–38. http://dx.doi.org/10.1128/mcb.10.2.528-538.1990.

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The chicken skeletal alpha-actin gene promoter region provides at least a 75-fold-greater transcriptional activity in muscle cells than in fibroblasts. The cis-acting sequences required for cell type-restricted expression within this 200-base-pair (bp) region were elucidated by chloramphenicol acetyltransferase assays of site-directed Bg/II linker-scanning mutations transiently transfected into primary cultures. Four positive cis-acting elements were identified and are required for efficient transcriptional activity in myogenic cells. These elements, conserved across vertebrate evolution, incl
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Dissertations / Theses on the topic "T cells Actins"

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Nassereddine, Aya. "Surface patterning strategies to dissect T-Cell adhesion and actin organisation." Thesis, Aix-Marseille, 2019. http://www.theses.fr/2019AIXM0458.

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Pour une réponse immunitaire efficace, une interaction optimale entre les cellules T et les cellules présentatrices d'antigène (APC) est nécessaire. Elle se présente sous la forme d'un contact cellulaire à différentes échelles allant du moléculaire (1-10 nm) au cellulaire (1-10 micromètres). La liaison entre les récepteurs spéciaux des cellules T (TCR) et leurs ligands sur une APC entraîne une réorganisation moléculaire à plus grande échelle menant d'abord à la formation de micro-clusters de TCR, puis à une restructuration à l'échelle cellulaire de la membrane et du cytosquelette. La création
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Regateiro, Frederico Eugenio de Castro Soares. "Probing the mechanisms of action of induced regulatory T cells." Thesis, University of Oxford, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.514982.

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Föger, Niko. "Costimulatory function of CD44 : acting in unison with the T cell receptor." kostenfrei, 2000. http://nbn-resolving.de/urn/resolver.pl?urn=nbn:de:bvb:20-opus-1186.

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Fields, Maria. "Homeostasis and function of Regulatory T Cells during Human Immunodeficiency Virus infection." University of Cincinnati / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1408709850.

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Zhang, Michael Sining. "Characterizing how glycerol monolaurate (GML) affects human T cell signaling and function." Diss., University of Iowa, 2018. https://ir.uiowa.edu/etd/6347.

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The T cell receptor (TCR) activation induced signaling cascade is a major driver of T cell effector responses such as cytokine production and actin cytoskeletal rearrangement. Characterizing chemical modulators of this pathway has the benefits of both revealing basic science knowledge about these signaling processes and providing foundation for development of novel therapeutics. Glycerol Monolaurate (GML) is a naturally occurring fatty acid monoester that is found as a monoglyceride in human breast milk and coconut oil. It is widely utilized in food, cosmetics, and homeopathic supplements. GML
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Saeed, Mezida Bedru. "Nanoscale rearrangements in cortical actin filaments at lytic immunological synapses." Thesis, University of Manchester, 2018. https://www.research.manchester.ac.uk/portal/en/theses/nanoscale-rearrangements-in-cortical-actin-filaments-at-lytic-immunological-synapses(8d00dd58-7b1a-435b-ad6c-016b12ff34d9).html.

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Lytic effector function of Natural Killer (NK) cells and CD8+ T cells occurs through discrete and regulated cell biological steps triggered by recognition of diseased cells. Recent studies of the NK cell synapse support the idea that dynamic nanoscale rearrangements in cortical filamentous (F)-actin are a critical cell biological checkpoint for lytic granule access to NK cell membrane. Loss of function mutations in the LYST gene, a well-characterised cause of Chediak- Hegashi syndrome (CHS), result in the formation of giant lysosomal organelles including lytic granules. Here, we report a misma
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Remon, Kerry. "DEF6 aggregation is linked to active translation and mRNA turnover in T cells." Thesis, University of Nottingham, 2017. http://eprints.nottingham.ac.uk/42985/.

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Spatiotemporal responses to extracellular signals have been documented in a wide variety of cells, such as neuronal synapses, cytotoxic T lymphocytes, germ cells and during embryo development. Selective release of a key molecule allows a cell to respond at a given moment, and cells ensure that the response can be initiated instantly by pre-producing and packaging the molecule, often storing the molecule as a granule. Differentially Expressed in FDCP6 is a guanine nucleotide exchange factor, primarily expressed in T cells, which has been previously shown to form cytoplasmic aggregates when phos
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Chen, Xinchun. "Effective Combination of Syngeneic HCT with CRCL Vaccination to Treat BCR-ABL+ Leukemia and CD4+CD25+FoxP3+ Regulatory T Cells Suppress Mycobacterium Tuberculosis Immunity in Patients with Active Disease." Diss., The University of Arizona, 2006. http://hdl.handle.net/10150/305143.

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Chronic myelogenous leukemia (CML) is a clonal hematopoetic stem cell disorder characterized by proliferation of cells expressing BCR-ABL fusion protein. In the BCR-ABL+ leukemia murine model, 12B1, we explored the therapeutic applicability of chaperone-rich cell lysate (CRCL) in the context of syngeneic hematopoietic cell transplantation (HCT) to treat pre-existing leukemia. Our results demonstrate that tumor growth is significantly delayed in mice receiving syngeneic HCT from 12B1 tumor CRCL immunized donors compared to animals receiving HCT from non-immunized donors. CRCL immunization post-
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Colin-York, Huw. "Investigating the active role of mechanical force during T-cell activation." Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:0b35bf22-f37f-4286-872d-ea174be82c77.

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The role of mechanical force has gained increasing interest in the field of cell biology owing to the realisation that cells are continually subject to stresses and strains induced by the cellular environment. Cells are known to be able to sense and react to forces imposed on them by their local environment as well as being able to directly impart force during motility, adhesion and cell division. This is also true for cells of the adaptive immune system, specifically during the intimate cell-cell interaction occurring between the T-cell and Antigen Presenting Cell (APC), known as the Immunolo
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Müller, Henrik. "Characterization of the cytokine profile in adults with latent and active tuberculosis from a high endemic country." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2011. http://dx.doi.org/10.18452/16317.

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Charakterisierung des Zytokinprofils in Erwachsenen mit einer latenten oder aktiven Tuberkulose in einem hoch endemischen Gebiet Die Tuberkulose (TB) stellt mit rund 2 Milliarden Infizierten weltweit ein globales gesundheitliches Problem dar. Während die große Mehrheit der infizierten Personen in der Lage sind die Krankheit zu kontrollieren, entwickelt sich bei ungefähr 10 % die aktive Form der TB aus. Der zugrunde liegende immunologische Prozess für diese Verteilung ist bis heute nicht bekannt und im Fokus dieser Arbeit. Das adaptive Immunsystem spielt eine entscheidende Rolle in der Immuna
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Books on the topic "T cells Actins"

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Wiegers, Gerrit-Jan. Glucocorticoid hormone action in the immune system revisited. EburonP&L, 1995.

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Byrne, John H. An introduction to membrane transport and bioelectricity. Raven Press, 1988.

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Byrne, John H. An introduction to membrane transport and bioelectricity: Foundations of general physiology and electrochemical signaling. 2nd ed. Raven Press, 1994.

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Flanagan, Stuart. Pneumocystis jirovecii. Edited by Christopher C. Kibbler, Richard Barton, Neil A. R. Gow, Susan Howell, Donna M. MacCallum, and Rohini J. Manuel. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780198755388.003.0019.

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In humans, Pneumocystis pneumonia is caused by a yeast-like fungus Pneumocystis jirovecii. Originally called P. carinii, this organism was thought to be a protozoan; however, the discovery of chitin, β‎-1,3-glucan, and ergosterol in the cell wall confirmed it as a fungus. DNA analysis demonstrated that the human disease was caused by P. jirovecii, while P. carinii was found to infect rats. P. jirovecii resides in mammalian lung tissue, usually without ill effects, but in immunocompromised hosts it becomes pathogenic and causes respiratory infection. P. jirovecii has been isolated from air and
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Misbah, Siraj. Immunosuppressive therapy and therapeutic monoclonal antibodies. Edited by Patrick Davey and David Sprigings. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199568741.003.0302.

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The term immunosuppressive therapy encompasses all forms of treatment that dampens function of the recipient’s immune system, with a view to controlling severe autoimmune, inflammatory, or allergic disease. The predominant targets of these agents are T-lymphocytes with multiple downstream effects, including containment of T-cell activation, inhibition of cytokine production, restriction of clonal expansion, and varying degrees of suppression of B-cell function. This chapter reviews the clinical use of monoclonal antibodies and other immunosuppressive agents, and their mechanisms of action.
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Badour, Karen Elizabeth. The Wiskott-Aldrich syndrome protein: Forging a link between actin polymerization and T cell activation. 2005.

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Muthukumar, Thangamani, Darshana Dadhania, Choli Hartono, and Manikkam Suthanthiran. Immunology, sensitization, and histocompatibility. Edited by Jeremy R. Chapman. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199592548.003.0279.

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Allograft rejection of the histo-incompatible allograft involves a highly orchestrated action of multiple cell types and mediators, with lymphocytes responsible for the identification of the foreignness of the allograft. The immune response directed against the donor is primarily, but not exclusively, directed at the donor’s major histocompatibility complex region class I and class II proteins. This chapter describes the immunobiology of the T cell and the role of human leucocyte antigens in clinical transplantation, thus identifying the targets for manipulation of the immune response by immun
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Mouyis, Maria, and David Isenberg. Biologic therapies in systemic lupus erythematosus. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780198739180.003.0007.

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This chapter looks at the various biologic or target therapies that have been trialled and tested in the last two decades. The treatment of systemic lupus erythematosus (SLE) has progressed over the last few years due to an increased understanding of its pathogenesis; beginning with rituximab, one of the first biologics to be used, the chapter covers therapies up to the present day. Each subsection highlights the relevant mechanism of action which has led to new treatment options: anti-CD20 and 22, anti-B cell activating factors, anti-interferon alpha and anti-T cell activation. A summarized t
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Shuy, Roger W. Cooperating Witnesses Use Deceptive Ambiguity. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780190669898.003.0006.

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Cooperating witness are individuals who replace agents in undercover operations, often because they are con men who the police have caught in a crime, are believable experts about how the crime works, and expect to receive lighter sentences for their cooperation with law enforcement. This chapter describes three investigations in which the cooperating witnesses used deceptive ambiguity by misrepresenting the speech events that led to conflicting schemas about what they were doing, by manipulating and reinterpreting the targets’ agendas and speech acts, by using ambiguous conversational strateg
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Howard, Colin R. Arenaviruses. Oxford University Press, 2011. http://dx.doi.org/10.1093/med/9780198570028.003.0032.

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There are few groups of viral zoonoses that have attracted such widespread publicity as the arenaviruses, particularly during the 1960’s and 1970’s when Lassa emerged as a major cause of haemorrhagic disease in West Africa. More than any other zoonoses, members of the family are used extensively for the study of virus-host relationships. Thus the study of this unique group of enveloped, single-stranded RNA viruses has been pursued for two quite separate reasons. First, lymphocytic choriomeningitis virus (LCM) has been used as a model of persistent virus infections for over half a century; its
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Book chapters on the topic "T cells Actins"

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Durum, Scott K., Alison Finnegan, Dan T. Brody, et al. "T Cell Interleukin 1." In Molecular Basis of Lymphokine Action. Humana Press, 1987. http://dx.doi.org/10.1007/978-1-4612-4598-8_11.

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Ayodele, Olubukola, and Lillian L. Siu. "New Drugs for Recurrent or Metastatic Nasopharyngeal Cancer." In Critical Issues in Head and Neck Oncology. Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-63234-2_23.

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AbstractChemotherapy has been the backbone for the treatment of recurrent or metastatic nasopharyngeal carcinoma (RMNPC), which remains an incurable disease. Currently the most active area of therapeutic investigations in RMNPC is in immunotherapy, especially after the results of five anti-programmed death-1 (anti-PD-1) antibodies, i.e. pembrolizumab, nivolumab, camrelizumab, toripalimab and tislelizumab, have demonstrated monotherapy objective response rates of 21%–43%. Combinations using anti-PD1/L1 antibodies as backbone to evaluate their additivity or synergy with cytotoxic chemotherapy, molecularly targeted agents, or other immuno-oncology compounds are actively being developed. Besides immune checkpoint blockade, additional ways to modulate the host immune system, such as Epstein-Barr virus (EBV)-directed vaccination against viral antigens (such as EBNA1, LMP1, LMP2) with dendritic cells or peptides, adoptive cell transfer of autologous or HLA-matched allogeneic EBV-specific cytotoxic T lymphocytes, CAR or TCR T-cell therapy, personalized cancer vaccines and oncolytic viruses are being explored. Finally, novel molecularly targeted agents that have entered human testing in RMNPC include apatinib and anlotinib (antiangiogenic agents), MAK683 (an embryonic ectoderm development or EED protein inhibitor), among others. This review provides an update of ongoing clinical trials evaluating these new compounds in RMNPC.
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Taniguchi, Masaru, Eiki Matsushita, Kenji Imai, et al. "Suppressor T Cell Receptor and Functional Molecule." In Molecular Basis of Lymphokine Action. Humana Press, 1987. http://dx.doi.org/10.1007/978-1-4612-4598-8_2.

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Verschueren, Hendrik, Georges K. De Bruyne, Daniel Dekegel, Marc M. Mareel, and Patrick De Baetselier. "The Invasive Behaviour of Murine T-Lymphoma Cells In Vitro." In Biomechanics of Active Movement and Deformation of Cells. Springer Berlin Heidelberg, 1990. http://dx.doi.org/10.1007/978-3-642-83631-2_17.

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Mittelstadt, P. R., J. Galon, D. Franchimont, J. J. O’Shea, and J. D. Ashwell. "Glucocorticoid-Inducible Genes That Regulate T-Cell Function." In Recent Advances in Glucocorticoid Receptor Action. Springer Berlin Heidelberg, 2002. http://dx.doi.org/10.1007/978-3-662-04660-9_18.

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Hoyt, D. B., E. Pinney, and A. N. Ozkan. "Trauma Peptide T-Cell Suppression: Mechanisms of Action." In Immune Consequences of Trauma, Shock, and Sepsis. Springer Berlin Heidelberg, 1989. http://dx.doi.org/10.1007/978-3-642-73468-7_37.

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Dantzer, Robert, Sophie Layé, Emmanuelle Goujan, et al. "Mechanisms of action of cytokines on the central nervous system. Interaction with glucocorticoids." In Steroid Hormones and the T-Cell Cytokine Profile. Springer London, 1997. http://dx.doi.org/10.1007/978-1-4471-0931-0_1.

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Miller, Bonnie C., Dwain L. Thiele, Don Rodd, Louis B. Hersh, and G. Larry Cottam. "Active β-Endorphin Metabolites Generated by T-Cell Ectopeptidases." In The Brain Immune Axis and Substance Abuse. Springer US, 1995. http://dx.doi.org/10.1007/978-1-4615-1951-5_8.

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Mosmann, Tim R., Holly Cherwinski, Daniel Cher, and Robert L. Coffman. "Two Types of Mouse Helper T Cell Clone: Differences in B Cell Help and Lymphokine Synthesis." In Molecular Basis of Lymphokine Action. Humana Press, 1987. http://dx.doi.org/10.1007/978-1-4612-4598-8_14.

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Casten, Lisa A., Pravin Kaumaya, Mark S. Anderson, John A. Smith, and Susan K. Pierce. "Solid phase synthesis of biologically active antigenic peptides for T-cells." In Peptides. Springer Netherlands, 1988. http://dx.doi.org/10.1007/978-94-010-9595-2_156.

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Conference papers on the topic "T cells Actins"

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Kumar, A., J. Fareed, W. H. Wehrmacher, D. Hoppensteadt, O. Ulutin, and J. M. Walenga. "ENDOTHELIAL FUNCTION MODULATION AND CONTROL OF VASCULAR AND THROMBOTIC DISORDERS: EXPERIMENTAL RESULTS WITH A POLYDEOXY RIBONUCLEOTIDE AGENT DEFIBROTIDE." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643149.

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Numerous approaches with single and multiple drugs modulating protease cascade, platelet function and blood viscosity and to reduce blood lipids to manage thrombotic processes have been tried. Defibrotide, a polydeoxyribonucleotide, (Mr =17,000) offers a new approach to vascular and related thrombotic processes as it acts via modulation of endothelial cell function. We have used a primate model (Macaca mulatta) to study the endogenous action of this agent after the oral (10-25 mg/kg) and intravenous (5-10 mg/kg) administration. This agent produced no effect on clotting tests and ex vivo labora
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Wasi, S., S. Juodvalkis, P. Alles, and J. E. Aubin. "STUDIES ON THE DIRECT PROTEOLYTIC ACTION OF HUMAN TISSUE PLASMINOGEN ACTIVATOR ON HUMAN FIBRONECTIN AND VITRONECTIN." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644376.

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The ability of cells to make or break specific attachments to extracellular matrix (ECM) and other cells is important in cell migration, proliferation and wound repair. Specific attachment proteins believed to be involved in mediating these interactions comprise functional domains joined by protease sensitive segments. Proteases can conceivably modulate cellular interactions by releasing functional domains from parent molecules. Tissue plasminogen activator (t-pA) is known to participate in various pathophysiological processes. That t-pA may also act directly on structural proteins has not bee
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Ho, Chen-Ta, and Cheng-Hsien Liu. "Micro T-Switches for Cell Sorting Applications." In ASME 2004 International Mechanical Engineering Congress and Exposition. ASMEDC, 2004. http://dx.doi.org/10.1115/imece2004-61427.

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A new micro-T-switch actuated by electrochemical bubbles for cells sorting has been proposed and successfully demonstrated by MEMS micromachining technique. We take advantage of electrolysis-bubbles, which have the features of low operation temperature and high surface-tension force, to actuate the micro T- switches in our device. The micro-T-switch is placed at the junction of the T-shapes microchannel. The movable T-structure design makes cell sorting active and programmable compared with other passive cell sorting mechanism such as micro-filters. Furthermore, the low operation temperature f
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Dong, Chen. "In Vitro Imaging Technique of Cell Adhesion." In ASME 2002 Pressure Vessels and Piping Conference. ASMEDC, 2002. http://dx.doi.org/10.1115/pvp2002-1630.

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It is the first object of this article to contribute a side-view imaging technique to investigate adhesion to a surface-immobilized ICAM-1 in shear flow, wherein T-leukemic Jurket cells have been used. A side view image has revealed that the cell adhesion on ICAM-1 under flow conditions in vitro is quasistratic. Changes in flow shear stress, cell deformability, or substrate ligand strength resulted in a significant change in the characteristic adhesion binding time and contact length. The elongation of cells in shear flow tempers hydrodynamic shear forces on the cell, which affects the transie
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Meng, Wilson S., Jeffrey R. Kovacs, and Ellen S. Gawalt. "The Use of Non-Viral Nucleic Acids Carriers for the Modulation of Leukocytes." In ASME 2008 Conference on Smart Materials, Adaptive Structures and Intelligent Systems. ASMEDC, 2008. http://dx.doi.org/10.1115/smasis2008-348.

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Induction of drug-free permanent organ accommodation is the ultimate goal of transplant therapy. Current pharmacological agents, however, are non-specific in their actions and generally do not confer immunological tolerance. Inhibitors of T cell receptor signaling (tacrolimus and cyclosporine A) represent the mainstay in transplant management. These agents exert their therapeutic effects by dampening the activities of all T cells. Chronic exposure to these agents increases the risk of developing opportunistic infections and malignancies. Given that more than 20,000 Americans undergo organ tran
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Jeanneaus, Ch, and Y. Sultan. "ULTRASTRUCTURAL LOCALIZATION AND CHARACTERISATION OF VON WILLEBRAND FACTOR (VWF) AND TISSUE PLASMINOGEN ACTIVATOR (t-PA) IN ENDOTHELIAL CELLS (EC) AND MEGAKARYOCYTES (MK)." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1642911.

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The reciproqual localization of VWF and t-PA in EC and MK was analysed in EM using immunocytochemical techniques. In parallel, PAGE electrophoresis, zymographic analysis and immuno-blotting were also performed in cell extracts using specific polyclonal and monoclonal antibodies against VWF and t-PA. By immunofluorescence, VWF showed a dense granular pattern in EC, MK and platelets, although no fluorescence was observed with specific antibodies to t-PA. In contrast, at optical level, with peroxidase or alcaline phosphatase conjugated antibodies, t-PA antigen in EC, MK and platelets appear light
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Liu, Shumin, Weidong Lyu, Yang Lei, et al. "Abstract 1868: A long acting bi-specific T cell engager differentially targeting CD47 positive malignant cells but not CD47 expressing healthy cells." In Proceedings: AACR Annual Meeting 2021; April 10-15, 2021 and May 17-21, 2021; Philadelphia, PA. American Association for Cancer Research, 2021. http://dx.doi.org/10.1158/1538-7445.am2021-1868.

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Kooistra, T., J. A. van den Berg, H. A. M. Tüns, G. Platenburg, D. Rijken, and E. A. van den Berg. "BUTYRATE SPECIFICALLY STIMULATES TISSUE-TYPE PLASMINOGEN ACTIVATOR SYNTHESIS IN CULTURED HUMAN ENDOTHELIAL CELLS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644656.

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In a search for compounds that can enhance tissue-type plasminogen activator (t-PA) synthesis in cultured human endothelial cells we found that dibutyryl cyclic AMP (at a concentration of 2 mM) led to a several-fold increase in t-PA production by endothelial cells over a 24 h incubation period. Further researchshowed that this stimulating effectcould be explained by the slow liberation of butyrate, as the effect could be reproduced by addition of free butyrate to the medium, but notby addition of 8-bromo cyclic AMP. With butyrate, an accelerated accumulation of t-PA antigen in the conditioned
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Tamzalit, Fella, Mitchell S. Wang, Weiyang Jin, et al. "Abstract B190: WASP-dependent actin protrusions mechanically potentiate killing by cytotoxic T-cells." In Abstracts: Fourth CRI-CIMT-EATI-AACR International Cancer Immunotherapy Conference: Translating Science into Survival; September 30 - October 3, 2018; New York, NY. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/2326-6074.cricimteatiaacr18-b190.

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Artmann, G., R. Grebe, H. Wolff, R. Degenhardt, and H. Schmid-SchÖnbein. "NOVEL TECHIQUES FOR QUANTIFICATION OF RBC-SHAPE (RS) AND SHEAR INDUCED RBC ELONGATION (SIRE): APPLICATION FOR ANALYSIS OF DRUG INDUCED ALTERATIONS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644217.

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In the past, red cell resting shape could only be assessed by subjective scaling, red cell deformability by a variety of rheological tests that are extremelydifficult to standardize and which all subject the RBC to high deforming forces. None of the latter have been accepted as reference in haematology, haemorheologyor pharmacology. A recent development from our group now allows objective, numerical analysis of red cell membrane curvature (i.e. the echinocytic or stomatocytic deviation from the discocytic resting shape) by a tangent count procedure in optical sections through freely suspended,
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