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Relevant bibliographies by topics / T cells Actins / Dissertations / Theses

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Dissertations / Theses on the topic 'T cells Actins'

Author: Grafiati

Published: 4 June 2021

Last updated: 4 February 2022

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1

Nassereddine, Aya. "Surface patterning strategies to dissect T-Cell adhesion and actin organisation." Thesis, Aix-Marseille, 2019. http://www.theses.fr/2019AIXM0458.

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Pour une réponse immunitaire efficace, une interaction optimale entre les cellules T et les cellules présentatrices d'antigène (APC) est nécessaire. Elle se présente sous la forme d'un contact cellulaire à différentes échelles allant du moléculaire (1-10 nm) au cellulaire (1-10 micromètres). La liaison entre les récepteurs spéciaux des cellules T (TCR) et leurs ligands sur une APC entraîne une réorganisation moléculaire à plus grande échelle menant d'abord à la formation de micro-clusters de TCR, puis à une restructuration à l'échelle cellulaire de la membrane et du cytosquelette. La création

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2

Regateiro, Frederico Eugenio de Castro Soares. "Probing the mechanisms of action of induced regulatory T cells." Thesis, University of Oxford, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.514982.

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3

Föger, Niko. "Costimulatory function of CD44 : acting in unison with the T cell receptor." kostenfrei, 2000. http://nbn-resolving.de/urn/resolver.pl?urn=nbn:de:bvb:20-opus-1186.

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4

Fields, Maria. "Homeostasis and function of Regulatory T Cells during Human Immunodeficiency Virus infection." University of Cincinnati / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1408709850.

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5

Zhang, Michael Sining. "Characterizing how glycerol monolaurate (GML) affects human T cell signaling and function." Diss., University of Iowa, 2018. https://ir.uiowa.edu/etd/6347.

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The T cell receptor (TCR) activation induced signaling cascade is a major driver of T cell effector responses such as cytokine production and actin cytoskeletal rearrangement. Characterizing chemical modulators of this pathway has the benefits of both revealing basic science knowledge about these signaling processes and providing foundation for development of novel therapeutics. Glycerol Monolaurate (GML) is a naturally occurring fatty acid monoester that is found as a monoglyceride in human breast milk and coconut oil. It is widely utilized in food, cosmetics, and homeopathic supplements. GML

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6

Saeed, Mezida Bedru. "Nanoscale rearrangements in cortical actin filaments at lytic immunological synapses." Thesis, University of Manchester, 2018. https://www.research.manchester.ac.uk/portal/en/theses/nanoscale-rearrangements-in-cortical-actin-filaments-at-lytic-immunological-synapses(8d00dd58-7b1a-435b-ad6c-016b12ff34d9).html.

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Lytic effector function of Natural Killer (NK) cells and CD8+ T cells occurs through discrete and regulated cell biological steps triggered by recognition of diseased cells. Recent studies of the NK cell synapse support the idea that dynamic nanoscale rearrangements in cortical filamentous (F)-actin are a critical cell biological checkpoint for lytic granule access to NK cell membrane. Loss of function mutations in the LYST gene, a well-characterised cause of Chediak- Hegashi syndrome (CHS), result in the formation of giant lysosomal organelles including lytic granules. Here, we report a misma

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7

Remon, Kerry. "DEF6 aggregation is linked to active translation and mRNA turnover in T cells." Thesis, University of Nottingham, 2017. http://eprints.nottingham.ac.uk/42985/.

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Spatiotemporal responses to extracellular signals have been documented in a wide variety of cells, such as neuronal synapses, cytotoxic T lymphocytes, germ cells and during embryo development. Selective release of a key molecule allows a cell to respond at a given moment, and cells ensure that the response can be initiated instantly by pre-producing and packaging the molecule, often storing the molecule as a granule. Differentially Expressed in FDCP6 is a guanine nucleotide exchange factor, primarily expressed in T cells, which has been previously shown to form cytoplasmic aggregates when phos

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8

Chen, Xinchun. "Effective Combination of Syngeneic HCT with CRCL Vaccination to Treat BCR-ABL+ Leukemia and CD4+CD25+FoxP3+ Regulatory T Cells Suppress Mycobacterium Tuberculosis Immunity in Patients with Active Disease." Diss., The University of Arizona, 2006. http://hdl.handle.net/10150/305143.

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Chronic myelogenous leukemia (CML) is a clonal hematopoetic stem cell disorder characterized by proliferation of cells expressing BCR-ABL fusion protein. In the BCR-ABL+ leukemia murine model, 12B1, we explored the therapeutic applicability of chaperone-rich cell lysate (CRCL) in the context of syngeneic hematopoietic cell transplantation (HCT) to treat pre-existing leukemia. Our results demonstrate that tumor growth is significantly delayed in mice receiving syngeneic HCT from 12B1 tumor CRCL immunized donors compared to animals receiving HCT from non-immunized donors. CRCL immunization post-

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9

Colin-York, Huw. "Investigating the active role of mechanical force during T-cell activation." Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:0b35bf22-f37f-4286-872d-ea174be82c77.

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The role of mechanical force has gained increasing interest in the field of cell biology owing to the realisation that cells are continually subject to stresses and strains induced by the cellular environment. Cells are known to be able to sense and react to forces imposed on them by their local environment as well as being able to directly impart force during motility, adhesion and cell division. This is also true for cells of the adaptive immune system, specifically during the intimate cell-cell interaction occurring between the T-cell and Antigen Presenting Cell (APC), known as the Immunolo

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10

Müller, Henrik. "Characterization of the cytokine profile in adults with latent and active tuberculosis from a high endemic country." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2011. http://dx.doi.org/10.18452/16317.

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Charakterisierung des Zytokinprofils in Erwachsenen mit einer latenten oder aktiven Tuberkulose in einem hoch endemischen Gebiet Die Tuberkulose (TB) stellt mit rund 2 Milliarden Infizierten weltweit ein globales gesundheitliches Problem dar. Während die große Mehrheit der infizierten Personen in der Lage sind die Krankheit zu kontrollieren, entwickelt sich bei ungefähr 10 % die aktive Form der TB aus. Der zugrunde liegende immunologische Prozess für diese Verteilung ist bis heute nicht bekannt und im Fokus dieser Arbeit. Das adaptive Immunsystem spielt eine entscheidende Rolle in der Immuna

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11

McGregor, Reuben Hendrik Cameron. "Immunoregulatory effects of vitamin D and its mechanism of action in CD4+ T cells." Thesis, King's College London (University of London), 2017. https://kclpure.kcl.ac.uk/portal/en/theses/immunoregulatory-effects-ofvitamin-d-and-its-mechanism-of-action-in-cd4-t-cells(c5b983f9-2a27-48ce-b1a6-89569416a82b).html.

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Vitamin D (VitD) deficiency has been implicated in the pathogenesis of multiple diseases including chronic kidney disease (CKD). VitD has direct effects on most cells in the innate and adaptive immune system including; CD4+ T cells and dendritic cells (DCs) both of which express the vitamin D receptor (VDR). This thesis, divided into two distinct parts, dissects the effects of: a) in vivo repletion of VitD in a placebo controlled, double blinded clinical trial in CKD patients. Here we hypothesised that repletion with cholecalciferol in VitD insufficient/deficient adult patients would ameliorat

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12

Ha, Hong Clinical School St Vincent's Hospital Faculty of Medicine UNSW. "Role of T cells and cytokines in the induction of tolerance to renal tubular antigen in active Heymann nephritis." Awarded by:University of New South Wales. Clinical School - St Vincent's Hospital, 2007. http://handle.unsw.edu.au/1959.4/40871.

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Idiopathic Membranous nephropathy (MN) is a common cause of nephrotic syndrome in humans, and many patients progress to end-stage kidney disease. The best available animal model of MN is active Heymann nephritis (HN) in which rats are immunized with renal tubular antigen (RTA) in complete Freund's adjuvant (CFA). Rats develop heavy proteinuria, a key measure of glomerular damage, and the disease is histologically identical to human MN. It has been thought that HN is mediated by antibody-based mechanisms. More recent evidence demonstrates a critical role for cytotoxic T cells. This thesis aims

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Schuck, Sebastian D. "Mycobacterium tuberculosis-specific T-cell responses in latent infection and active disease." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2009. http://dx.doi.org/10.18452/15916.

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Adaptive Immunantworten gegen Mycobacterium tuberculosis (M. tuberculosis) sind von entscheidender Bedeutung für die effektive Eindämmung des Erregers sowie den Schutz vor einer erneuten, sekundären Tuberkulose (TB). Obwohl Schlüsselfaktoren wie die Th1 Zytokine IFN-gamma und TNF-alpha bekannt sind, blieben Bemühungen zur Identifizierung eindeutiger immunologischer Parameter, welche ausschlaggebend für den Krankheitsverlauf sind, bislang erfolglos. Ein besseres Verständnis der zugrunde liegenden Immunprozesse sowie die Identifikation projektiver Biomarker für TB sind zentrale Ziele dieser Arbe

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14

Bergström, Ida. "Pro- and anti-inflammatory actions in coronary artery disease : with focus on CD56+ T cells and Annexin A1." Doctoral thesis, Linköpings universitet, Avdelningen för kardiovaskulär medicin, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-114123.

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¨The atherosclerotic process is considered to be driven by an imbalance between proand anti-inflammatory actions. Still, the inflammatory state in patients with coronary artery disease (CAD) remains to be clarified. Annexin A1 (AnxA1) is a glucocorticoidinduced protein which may have a key role in the anti-inflammatory response as a mediator of glucocorticoid effects. The general aim of this thesis was to deepen the knowledge of pro- and antiinflammatory mechanisms in CAD via phenotypic assessments of immune cell subsets, in particular CD56+ T cells, and exploration of AnxA1. The long-term goa

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15

Shannon, Michael James. "Integrin nano-adhesions, the molecular clutch and actin dynamics in high speed T cell migration." Thesis, King's College London (University of London), 2017. https://kclpure.kcl.ac.uk/portal/en/theses/integrin-nanoadhesions-the-molecular-clutch-and-actin-dynamics-in-high-speed-t-cell-migration(284b8c39-f80c-42ac-8135-0b8afeeb5eb3).html.

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T cells navigate the body using constant actin flow, which transiently engages with a spatially and mechanically controlled ‘molecular clutch’ to produce torque and forward cell movement. The clutch is composed of affinity regulated integrin, actin linkers and phospho-regulators, modulated on the nanoscale as T cells move through blood vessels, tissues and lymph nodes. Cells with a point mutation in a gene linked to integrin signalling (PTPN22) exhibit increased adhesion and migration, and in humans the same mutation predisposes for seven different autoimmune diseases. Here, super resolution l

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16

Tonon, Sandrine. "La toxine de Bordetella pertussis active les cellules dendritiques et les lymphocytes T CD4 naïfs chez l'homme." Doctoral thesis, Universite Libre de Bruxelles, 2006. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/210749.

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La toxine de pertussis (PTX) est une A-B protéine considérée comme l’un des principaux facteurs de virulence de Bordetella pertussis, l’agent bactérien responsable de la coqueluche. Aujourd’hui, cette maladie représente encore un réel danger pour les nouveaux-nés et les<p>nourrissons non ou partiellement immunisés. Actuellement, la coqueluche provoque encore la<p>mort d’environ 350.000 individus par an. La toxicité de la PTX est liée à l’activité<p>enzymatique de sa sous-unité A capable d’inhiber les voies de signalisation associées aux<p>protéines Gi. La partie B, quant à elle, permet l’entré

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17

Del, Río Iñiguez Iratxe. "Intracellular vesicle traffic, immunological synapse and T cell activation. Modulation by Human Immunodeficiency Virus type 1 Rac1-Rab11-FIP3 regulatory hub coordinates vesicle traffic with actin remodeling and T cell activation Rab11-FIP3 regulation of Lck endosomal traffic controls TCR signal transduction." Thesis, Sorbonne université, 2018. http://www.theses.fr/2018SORUS561.

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La formation et les fonctions de la synapse immunologique sont le résultat d’un processus de polarisation cellulaire du lymphocyte T. Ce processus dépend de l’action coordonnée du cytosquelette d’actine et de microtubules, et du trafic vésiculaire intracellulaire. Le récepteur T ainsi que des protéines impliquées dans sa signalisation intracellulaire sont associés à la membrane plasmique et à des compartiments vésiculaires endosomiaux, et circulent en continu entre ces deux localisations. Je montre dans cette thèse que la tyrosine kinase Lck et la GTPase Rac1 sont associés aux endosomes exprim

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18

Okwor, Chisom Ifeoma Adaeze. "Understanding Immune Suppression in Patients with Chronic Hepatitis C Virus Infections." Thesis, Université d'Ottawa / University of Ottawa, 2021. http://hdl.handle.net/10393/41856.

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Hepatitis C Virus (HCV) is a small RNA virus that progresses to chronicity in 50-80% of infected individuals. Direct-acting antivirals (DAAs) are revolutionary treatments for HCV with 90-98% cure rates. However, over time, chronic HCV infections can result in advanced liver disease, including cirrhosis. Patients with advanced fibrosis experience a poor response to vaccination, recurrent infections and increased risk for hepatocellular carcinoma (HCC). These outcomes are, in part, a consequence of immune dysfunction. Increased inhibitory receptor and Galectin-9 (GAL-9) expression is a possible

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19

Müller, Philipp. "Studies on the role of Coronin 1 and the actin cytoskeleton in T cell signaling and survival /." Basel : [s.n.], 2009. http://edoc.unibas.ch/diss/DissB_8908.

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20

Singh, Noopur. "Mechanism of action and recruitment of antigen-presenting cells in a mouse model of multiple sclerosis." Doctoral thesis, Université Laval, 2021. http://hdl.handle.net/20.500.11794/68073.

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La sclérose en plaques (SEP) est largement acceptée comme étant une maladie auto-immune du système nerveux central (SNC) dirigée par les cellules T auto-réactives. Cette maladie est très répandue au Canada. L'encéphalomyélite auto-immune expérimentale (EAE) est le modèle animal le plus utilisé pour l’étude de la SEP. Malgré l’importance des cellules T dans cette pathologie, il est important de souligner que ce sont les cellules présentatrices d'antigènes (CPA) myéloïdes, et surtout les cellules dendritiques (CD), qui amorcent l’activation des cellules T auto-réactives dans les organes lymphoïd

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21

Read, Simon. "The role of CD4'+' regulatory T cells in protection from inflammatory bowel disease : phenotype, ontogeny and mechanism of action." Thesis, University of Oxford, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.365754.

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22

Sardar, Harjinder Singh. "Molecular Interactions of Arabinogalactan-Proteins (AGPs) in Tobacco Bright Yellow-2 Cultured Cells and Functional Identification of Four Classical AGPs in Arabidopsis." Ohio University / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1187112623.

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23

Liu, Yuk-Fun. "Mechanisms of action of peptide immunotherapy for type 1 diabetes : characterising T-cells induced or modified by proinsulin C19-A3." Thesis, King's College London (University of London), 2018. https://kclpure.kcl.ac.uk/portal/en/theses/mechanisms-of-action-of-peptide-immunotherapy-for-type-1-diabetes(4da69e4e-6a2b-4f55-bad3-5c95f5cda38f).html.

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Peptide immunotherapy (PIT) is a specific immunomodulatory treatment aiming to tip the balance from pro8inflammatory attack to restoration of immune tolerance. It has been successfully translated into clinical practice in the field of allergy, stimulating ongoing research in autoimmune diseases including type 1 diabetes. The safety and mechanistic effects of proinsulin C198A3 (PI C198A3), a HLA8DR4 restricted, naturally processed and presented peptide, was assessed through a multicentre placebo controlled double8blind clinical trial of 2 or 4 weekly intradermal doses of 10µg peptide for 6 mont

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24

Dinic, Jelena. "Plasma membrane order; the role of cholesterol and links to actin filaments." Doctoral thesis, Stockholms universitet, Wenner-Grens institut, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-62279.

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The connection between T cell activation, plasma membrane order and actin filament dynamics was the main focus of this study. Laurdan and di-4-ANEPPDHQ, membrane order sensing probes, were shown to report only on lipid packing rather than being influenced by the presence of membrane-inserted peptides justifying their use in membrane order studies. These dyes were used to follow plasma membrane order in live cells at 37°C. Disrupting actin filaments had a disordering effect while stabilizing actin filaments had an ordering effect on the plasma membrane, indicating there is a basal level of orde

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Brundula, Sodja Veronika. "Inhibiting T cell migration as a therapeutic strategy for Multiple Sclerosis, minocycline and its mechanisms of action." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape4/PQDD_0019/MQ55198.pdf.

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26

Huang, Kuan-Hsiang Gary. "The impact of host and therapy mediated selection on HIV-1 evolution." Thesis, University of Oxford, 2010. http://ora.ox.ac.uk/objects/uuid:b49d0d79-75c9-4314-92ae-1f1789ac7d42.

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The Human immunodeficiency virus (HIV) pandemic has resulted in a heavy global disease burden, and clinically causes Acquired Immuno-Deficiency Syndrome (AIDS). The development of highly active antiretroviral therapy (HAART) has achieved remarkable control of the rapidly evolving HIV. However, HIV remains neither curable nor preventable by vaccine, and in the developing regions worst affected by HIV, HAART remains inaccessible to most patients. Furthermore, the change in both immunology and viral evolution during chronic HIV infection and its relation to AIDS pathogenesis remains unknown. Foll

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27

Winter, Sarah. "Identification and characterization of new genetic defects involved in Epstein-Barr virus immune response and T-cell proliferation Loss of RASGRP1 in humans impairs T-cell expansion leading to Epstein-Barr virus susceptibility RASGRP1 is a negative factor of EOMES expression in T cells in association with an exhausted phenotype IL-27RA deficiency in humans, a new cause of susceptibility to Epstein-Barr virus infection Association of bi-allelic loss-of-function mutations in PIK3CD and TNFRSF9 causes fatal chronic active Epstein-Barr virus infection with T-cell lymphoproliferation." Thesis, Sorbonne Paris Cité, 2018. http://www.theses.fr/2018USPCB180.

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L'infection par le virus d'Epstein-Barr (EBV) touche plus de 90% de la population mondiale et est dans la majorité des cas asymptomatique dans l'enfance. Certains individus, souvent à l'adolescence, développent une primo-infection symptomatique appelée mononucléose infectieuse. L'EBV peut également entraîner chez des individus immunodéprimés des désordres lymphoprolifératifs, des lymphomes ou syndromes d'activation lymphohistiocytaire. Depuis une trentaine d'années plusieurs déficits immunitaires primitifs entraînant une susceptibilité particulière à l'infection par l'EBV ont été identifiés ;

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Auma, Ann Winniefred Nangobi. "THE IMPACT OF DIRECT-ACTING ANTI-VIRAL THERAPY ON NAIVE CD4+ T CELL LYMPHOPENIA AND CELLULAR IMMUNE ACTIVATION IN HCV INFECTION AND HCV/HIV CO-INFECTION." Case Western Reserve University School of Graduate Studies / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=case1625764728651756.

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29

Schuck, Sebastian D. [Verfasser], Hans-Dieter [Gutachter] Volk, Stefan [Gutachter] Kaufmann, and Florian [Gutachter] Kern. "Mycobacterium tuberculosis-specific T-cell responses in latent infection and active disease / Sebastian D. Schuck ; Gutachter: Hans-Dieter Volk, Stefan Kaufmann, Florian Kern." Berlin : Humboldt-Universität zu Berlin, 2009. http://d-nb.info/1208078542/34.

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Karches, Clara [Verfasser], and Sebastian [Akademischer Betreuer] Kobold. "Characterization of the influence of antibody valency on murine synthetic agonistic receptor-transduced T cell activation and action / Clara Karches ; Betreuer: Sebastian Kobold." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2019. http://d-nb.info/1202011861/34.

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31

Chebel, Amel. "Influence de la stimulation et de la sénescence réplicative des lymphocytes T sur le métabolisme des télomères." Thesis, Lyon 1, 2010. http://www.theses.fr/2010LYO10008.

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Les lymphocytes constituent un modèle original de cellules somatiques puisqu’ils sont capables de réactiver la télomérase lorsqu’ils sont stimulés. Nous avons montré que les lymphocytes, en culture prolongée et soumis à des stimulations itératives par la PHA, présentent une diminution progressive de l’activité télomérasique interrompue à chaque stimulation par une augmentation transitoire. Ces variations sont corrélées positivement aux variations de hTERT et de la longueur des télomères. Les foyers γ-H2AX et 53BP1 et leur localisation au niveau des télomères augmentent lors du vieillissement c

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Moisan, Jean-Paul. "Etude et caracterisation de marqueurs genetiques specifiques du chromosome x humain (suivi de) etude des rearrangements du recepteur a l'antigene, sur des lymphocites t actives in vivo." Université Louis Pasteur (Strasbourg) (1971-2008), 1987. http://www.theses.fr/1987STR13231.

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Othmane, Omar. "Mecanisme d'action d'un immunomodulateur, le lf 1695 : effets in vitro et in vivo sur les lymphocytes t et sur l'autoimmunite." Limoges, 1986. http://www.theses.fr/1986LIMO0027.

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Yang, Hongbing. "Characterisation of CD8+T cell responses induced by therapeutic vaccination with HIV-1 clade A gag DNA- and recombinant modified vaccinia virus Ankara (MVA)-vectored vaccines in HIV-1 infected individuals recieving highly active antiretroviaral therapy." Thesis, University of Oxford, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.442987.

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Rivas, Fabiola Vania. "Regulation of T cell activation by map kinases and the actin cytoskeleton /." 2003. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pqdiss&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&rft_dat=xri:pqdiss:3097153.

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Mayne, Elizabeth Sarah. "The role of regulatory T cells in adults in South Africa with active tuberculosis." Thesis, 2010. http://hdl.handle.net/10539/7484.

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Thesis (M.Med.(Haematology)), Faculty of Health Sciences, University of the Witwatersrand, 2009<br>Introduction Regulatory T cells (Tregs) are increasingly being recognized as key immunological players in immunosuppression and have been seen to be permissive for certain infections. Aim This study aimed to elucidate the role that Tregs play in symptomatic infection with Mycobacterium tuberculosis (TB), both with and without co-infection with human immunodeficiency virus type 1 (HIV 1) by quantification of these cells at ex vivo. It was then attempted to characterise the behaviour of FoxP

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Palmer, Ellen Marie. "Regulation of human T helper cell differentiation by the combined action of accessory molecules and cytokines /." 2000. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pqdiss&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&rft_dat=xri:pqdiss:9965134.

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Sedick, Qanita. "Analysis of gamma-delta T cells in black South African patients with active tuberculosis." Thesis, 2014. http://hdl.handle.net/10539/15477.

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A research report submitted to the Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, in partial fulfilment of the requirements for the degree, Master of Medicine in Haematopathology. Johannesburg, 2014<br>Mycobacterium Tuberculosis is the leading cause of morbidity and mortality due to infectious diseases worldwide. South Africa has ~20% of the world’s HIV associated Tuberculosis and has the second largest reported numbers of multidrug resistant (MDR) Tuberculosis in the world. Given the complexity of the mycobacterium and its ability to evade the immune system, there

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Koh, Byunghee. "Transcription factors and cis-acting elements in T helper cell cytokine expression." Diss., 2017. https://doi.org/10.7912/C2WD3S.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>The immune system provides resistance to the myriad of pathogens in the environment, but can also respond inappropriately causing allergic inflammation and autoimmune disease. CD4+ T cells, which play a crucial role in adaptive immune system, can be divided into several subsets based on their effector functions. T helper 9 (Th9) cells, derived by the IL-4/STAT6 and TGF-β signaling pathways, produce IL-9 as a hallmark cytokine, as well as IL-10. Through IL-9 production, Th9 cells protect against parasite infection but are also i

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Zhang, Wen. "Identification and characterization of Zfp206, a transcription factor active in ES cells." 2007. http://link.library.utoronto.ca/eir/EIRdetail.cfm?Resources__ID=742452&T=F.

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JeBailey, Lellean. "The role of Rho GTPases in insulin-induced actin remodelling and GLUT4 mobilization in L6 muscle cells." 2007. http://link.library.utoronto.ca/eir/EIRdetail.cfm?Resources__ID=478876&T=F.

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Hauff, Cornelia. "Aspects of the mode of action of bispecific T cell engager (BiTE) antibodies." Doctoral thesis, 2009. https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-48369.

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Bispecific T cell engager (BiTE) display a novel design among the class of bispecific antibodies and hold great promise to fight diverse cancers. BiTE molecules consist of two different binding entities derived from two human IgG antibodies connected by a short peptide linker. Their binding arms are directed against the CD3e chain of the T cell receptor on T cells and against an antigen that is specific for (e.g., CD19 for lymphoma in MT103) or over-expressed on (e.g., EpCAM for epithelial cancer in MT110) tumor cells. Without requirement for pre- or co-stimulation, BiTE molecules efficiently

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Talaei, Nafiseh. "Abelson family kinases regulate actin cytoskeleton dynamics in immunological synapse formation and T cell migration." 2009. http://link.library.utoronto.ca/eir/EIRdetail.cfm?Resources__ID=958041&T=F.

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Badour, Karen Elizabeth. "The Wiskott-Aldrich syndrome protein : forging a link between actin polymerization and T cell activation." 2005. http://link.library.utoronto.ca/eir/EIRdetail.cfm?Resources__ID=232849&T=F.

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Nelson, Kimberlea Lynne. "Elucidation of the mode of action of the pore-forming toxin aerolysin on T lymphomas." Thesis, 2000. https://dspace.library.uvic.ca//handle/1828/9673.

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Aerolysin is a channel-forming protein toxin secreted by virulent Aeromonas species. The toxin binds to receptors on cells, is proteolytically activated, and then assembles into a heptameric oligomer, which inserts into the plasma membrane forming a functional channel, resulting in cell death. To further characterize these steps receptor identification, the effect of membrane domains on channel formation and the mode of cell death were investigated on T lymphomas. Screening of cell lysates for proaerolysin-binding proteins N-glycosidase and phosphatidylinositol specific phospholipase C treatme

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Föger, Niko [Verfasser]. "Costimulatory function of CD44 : acting in unison with the T cell receptor / vorgelegt von Niko Föger." 2002. http://d-nb.info/968343716/34.

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Master, Zubin. "Identification and characterization of the signaling mechanisms downstream of Dok-R that mediate cell migration and actin reorganization." 2004. http://link.library.utoronto.ca/eir/EIRdetail.cfm?Resources__ID=94726&T=F.

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Schuck, Sebastian D. [Verfasser]. "Mycobacterium tuberculosis specific T-cell responses in latent infection and active disease / von Sebastian D. Schuck." 2009. http://d-nb.info/994897367/34.

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Hauff, Cornelia [Verfasser]. "Aspects of the mode of action of bispecific T cell engager (BiTE) antibodies / vorgelegt von Cornelia Hauff." 2009. http://d-nb.info/1003240143/34.

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Momin, Mohamed. "Atomistic Insights into Binding Pocket Dynamics and Regulation in the Interleukin-2 T-Cell Kinase SH2 Domain." 2017. http://scholarworks.gsu.edu/chemistry_theses/102.

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Although the regulation of proteins functions by allosteric interactions has been identified in many subcellular processes, long-range conformational changes in proteins are also known to be induced by molecular switches. A molecular switch based on the cis-trans isomerization of a peptidyl-prolyl bond is capable of inducing a conformational change directly to the protein backbone, which is then propagated throughout the system. However, these switches are elusive and difficult to identify due to their intrinsic dynamics in the biomolecules where they are found. Herein, we explore the conforma

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