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Journal articles on the topic 'T cells Identification'

Author: Grafiati

Published: 4 June 2021

Last updated: 29 January 2023

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1

Aerts, Nicolaas E., Evelyne J. Dombrecht, Didier G. Ebo, Chris H. Bridts, Wim J. Stevens, and Luc S. De Clerck. "Activated T cells complicate the identification of regulatory T cells in rheumatoid arthritis." Cellular Immunology 251, no. 2 (2008): 109–15. http://dx.doi.org/10.1016/j.cellimm.2008.04.008.

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Graca, Luis, Stephen P. Cobbold, and Herman Waldmann. "Identification of Regulatory T Cells in Tolerated Allografts." Journal of Experimental Medicine 195, no. 12 (June 10, 2002): 1641–46. http://dx.doi.org/10.1084/jem.20012097.

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Induction of transplantation tolerance with certain therapeutic nondepleting monoclonal antibodies can lead to a robust state of peripheral “dominant” tolerance. Regulatory CD4+ T cells, which mediate this form of “dominant” tolerance, can be isolated from spleens of tolerant animals. To determine whether there were any extra-lymphoid sites that might harbor regulatory T cells we sought their presence in tolerated skin allografts and in normal skin. When tolerated skin grafts are retransplanted onto T cell–depleted hosts, graft-infiltrating T cells exit the graft and recolonize the new host. T

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3

Souter, M. N., C. V. Nguyen-Robertson, F. J. Ross, S. J. J. Reddiex, J. Waddington, I. Van Rhijn, S. B. G. Eckle, et al. "Identification and characterization of CD1-restricted T cells." Journal of Immunology 196, no. 1_Supplement (May 1, 2016): 206.6. http://dx.doi.org/10.4049/jimmunol.196.supp.206.6.

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Abstract Most studies of T cells have focused on those that respond to foreign peptides. However, other specialized populations of T cells exist that recognize lipid antigens and make up a substantial component of the human immune system. These lipid reactive T cells recognize antigens presented by antigen presentation molecules from the CD1 family. Four CD1 molecules exist (CD1a, CD1b, CD1c and CD1d), and each is capable of presenting a unique repertoire of lipids antigens to T cells. Much of what we have learned about lipid reactive T cells stems from studies of CD1d restricted NKT cells as

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4

Illes, Z., T. Kondo, K. Yokoyama, T. Ohashi, T. Tabira, and T. Yamamura. "Identification of autoimmune T-cells among in vivo expanded CD25+ T-cells in multiple sclerosis." Journal of Neuroimmunology 90, no. 1 (September 1998): 73. http://dx.doi.org/10.1016/s0165-5728(98)91617-4.

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5

Illés, Zsolt, Takayuki Kondo, Kazumasa Yokoyama, Takashi Ohashi, Takeshi Tabira, and Takashi Yamamura. "Identification of Autoimmune T Cells Among In Vivo Expanded CD25+ T Cells in Multiple Sclerosis." Journal of Immunology 162, no. 3 (February 1, 1999): 1811–17. http://dx.doi.org/10.4049/jimmunol.162.3.1811.

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Abstract Although clonal expansion of autoimmune T cells has been reported in multiple sclerosis (MS), very limited information is available on specificities, clonal size, or activation state of the expanded clones. Here we address the issue of clonal expansion by using a novel technique demonstrating clonotypes defined by single-strand conformation polymorphism of TCR β-chain cDNAs. Examination of activated T cells (CD3+CD25+) isolated from the peripheral blood of MS revealed limited numbers (20∼82) of expanded clones defined by single-strand conformation polymorphism clonotype. To estimate t

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6

Baseggio, L., F. Berger, D. Morel, M.-h. Delfau-Larue, G. Goedert, G. Salles, J.-p. Magaud, and P. Felman. "Identification of circulating CD10 positive T cells in angioimmunoblastic T-cell lymphoma." Leukemia 20, no. 2 (December 8, 2005): 296–303. http://dx.doi.org/10.1038/sj.leu.2404013.

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7

Azimi, Maryam, Saeed Aslani, Sahar Mortezagholi, Amir Salek, Mohammad Reza Javan, Alireza Rezaiemanesh, Mojgan Ghaedi, Mehrdad Gholamzad, and Eisa Salehi. "Identification, Isolation, and Functional Assay of Regulatory T Cells." Immunological Investigations 45, no. 7 (July 15, 2016): 584–602. http://dx.doi.org/10.1080/08820139.2016.1193869.

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8

Kobayashi, Hiroya, and Esteban Celis. "Peptide epitope identification for tumor-reactive CD4 T cells." Current Opinion in Immunology 20, no. 2 (April 2008): 221–27. http://dx.doi.org/10.1016/j.coi.2008.04.011.

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9

Gerli, Roberto, Giuseppe Nocentini, Alessia Alunno, Elena Bartoloni Bocci, Rodolfo Bianchini, Onelia Bistoni, and Carlo Riccardi. "Identification of regulatory T cells in systemic lupus erythematosus." Autoimmunity Reviews 8, no. 5 (March 2009): 426–30. http://dx.doi.org/10.1016/j.autrev.2009.01.004.

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10

Cardarelli, P. M., and M. D. Pierschbacher. "Identification of fibronectin receptors on T lymphocytes." Journal of Cell Biology 105, no. 1 (July 1, 1987): 499–506. http://dx.doi.org/10.1083/jcb.105.1.499.

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We report the identification of fibronectin receptors on thymocytes and T lymphoma cells. Affinity chromatography of extracts of the T cell lymphoma, WR16.1, on a fibronectin-Sepharose column combined with specific elution using a synthetic peptide containing the cell attachment-promoting sequence, arginine-glycine-aspartic acid, yielded two polypeptide components having apparent molecular masses of approximately 160 kD reduced and 175 and 150 kD nonreduced. Immunoprecipitations from surface-iodinated WR16.1 cells or fibronectin-adherent thymocytes using a rabbit antiserum raised against the f

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11

Kasheta, Melissa, Corrie A. Painter, Finola E. Moore, Riadh Lobbardi, Alysia Bryll, Eli Freiman, David Stachura, et al. "Identification and characterization of T reg–like cells in zebrafish." Journal of Experimental Medicine 214, no. 12 (October 24, 2017): 3519–30. http://dx.doi.org/10.1084/jem.20162084.

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Regulatory T (T reg) cells are a specialized sublineage of T lymphocytes that suppress autoreactive T cells. Functional studies of T reg cells in vitro have defined multiple suppression mechanisms, and studies of T reg–deficient humans and mice have made clear the important role that these cells play in preventing autoimmunity. However, many questions remain about how T reg cells act in vivo. Specifically, it is not clear which suppression mechanisms are most important, where T reg cells act, and how they get there. To begin to address these issues, we sought to identify T reg cells in zebrafi

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12

Tretter, Theresa, Ram KC Venigalla, Volker Eckstein, and Hanns-Martin Lorenz. "Identification of human B cells with immunoregulatory properties (92.12)." Journal of Immunology 178, no. 1_Supplement (April 1, 2007): S165. http://dx.doi.org/10.4049/jimmunol.178.supp.92.12.

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Abstract Regulation of immune responses and tolerance is mediated by a variety of mechanisms and cells. So far the role of B cells in this process is not well known, yet. Methods: Highly purified CD19+B and CD4+T cells were separated from human PBMC by MACS. B cells were prestimulated with SAC, αIgM/IgG or αCD40, washed and set up in cocultures with freshly isolated autologous CD4+T cells under addition of αCD3+IL-2 or αCD28. CD4+ T cell proliferation was determined after 3–6d by 3H Thymidine incorporation and PKH-26; apoptosis by AnnexinV. Results: under optimal stimulatory conditions T cell

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13

Schwarz, Benjamin A., and Avinash Bhandoola. "Identification of Thymus Settling Progenitors." Blood 104, no. 11 (November 16, 2004): 2677. http://dx.doi.org/10.1182/blood.v104.11.2677.2677.

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Abstract T cells develop in the thymus, but are ultimately derived from hematopoietic stem cells (HSCs) that reside in the bone marrow. In order to produce T cells throughout adult life, the thymus must be periodically seeded by bone marrow progenitors via the blood. The identity of progenitors that seed the adult thymus is unknown. To determine which bone marrow progenitors that have access to they thymus, we analyzed the blood of adult mice (Schwarz & Bhandoola, Nature Immunology 2004). We found that the only progenitors in blood with T lineage potential were lineage negative cells with

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14

Greaves, Sarah A., Michael Falta, Radleigh Santos, Clemencia Pinilla, Johan Grunewald, and Andrew Fontenot. "Identification of T cell epitopes in sarcoidosis." Journal of Immunology 204, no. 1_Supplement (May 1, 2020): 224.26. http://dx.doi.org/10.4049/jimmunol.204.supp.224.26.

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Abstract Sarcoidosis is an inflammatory granulomatous disease that primarily affects the lung. It has a worldwide distribution and affects individuals of all ages. Despite the prevalence of the disease, the cause of sarcoidosis remains unknown. Evidence suggests that CD4+ T cells in the bronchoalveolar lavage (BAL) of sarcoidosis patients are instrumental in disease progression. Löfgren’s syndrome (LS) is an acute form of sarcoidosis with a specific set of inflammatory symptoms. In patients with LS, disease susceptibility has been associated with expression of HLA-DR3 and an expansion of BAL C

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15

Garcia-Guerrero, Estefania, Luis I. Sanchez-Abarca, Esther Domingo, Teresa Ramos, Jose Antonio Bejarano-García, Jose A. Gonzalez-Campos, Teresa Caballero-Velázquez, and José A. Pérez-Simón. "Identification and Isolation of Tumor-Specific Cytotoxic T Lymphocytes in Acute Myeloid Leukemia Patients through the Identification of T-Cells Capable to Establish Stable Interactions with Leukemic Cells." Blood 132, Supplement 1 (November 29, 2018): 3336. http://dx.doi.org/10.1182/blood-2018-99-118118.

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Abstract Introduction Autologous adoptive T cell therapies, based on the use of tumor infiltrating lymphocytes (TILs), have made great progress in recent years for the treatment of solid tumors, especially melanoma. However, further work is needed to isolate tumor-reactive T cells among patients diagnosed with hematologic malignancies. The dynamics of the interaction between T cells and antigen presenting cells (APC) dictate the quality of the immune responses. While stable joints between target cells and T lymphocytes lead to the induction of T cell activation and immune response, brief conta

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16

LESESVE. "CAR-T cells microscopic and phenotypic identification in the peripheral blood." Mediterranean Journal of Hematology and Infectious Diseases 14, no. 1 (February 27, 2022): e2022024. http://dx.doi.org/10.4084/mjhid.2022.024.

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CAR-T cells are a new possibility for care poor prognostic conditions. CAR-T cells injection lead to T chimeric cells circulation into the blood. Here is reported the cytomorphologic and immunophenotypic features of CAR-T cells in the peripheral blood.

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17

Pietschmann, P., J. J. Cush, P. E. Lipsky, and N. Oppenheimer-Marks. "Identification of subsets of human T cells capable of enhanced transendothelial migration." Journal of Immunology 149, no. 4 (August 15, 1992): 1170–78. http://dx.doi.org/10.4049/jimmunol.149.4.1170.

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Abstract A critical step in immunologically mediated inflammation is the migration of T cells between endothelial cells of postcapillary venules and into the tissues. To determine whether specific cells are capable of transendothelial migration, T cells that had migrated through endothelial monolayers were retrieved and analyzed. To accomplish this, human umbilical vein endothelial cells (EC) were cultured to confluence on collagen gels and incubated with human T cells. T cells that were nonadherent to the EC, those that bound to the endothelium, and cells that had migrated through the endothe

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18

Kabelitz, D., and P. Conradt. "Identification of CD2-/CD3+ T cells in fetal human tissue." Journal of Experimental Medicine 168, no. 5 (November 1, 1988): 1941–46. http://dx.doi.org/10.1084/jem.168.5.1941.

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From 1 to 23% of fetal human spleen or thymus cells (from the 20th to 24th week of gestation) were found to display a previously unrecognized CD2-/CD3+ phenotype. IL-2-dependent, long-term clones of CD2-/3+ T cells did not react with a panel of anti-CD2 mAbs and did not form rosettes with sheep erythrocytes. These results show that (a) significant numbers of CD2-/3+ T cells are present in fetal human spleen and/or thymus; and (b) in contrast to the widely accepted view, expression of CD2 is not a prerequisite for the expression of the CD3 molecular complex on human T cells.

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19

Nelson, Michelle H., Hannah M. Knochelmann, Stefanie R. Bailey, Logan W. Huff, Jacob S. Bowers, Kinga Majchrzak-Kuligowska, Megan M. Wyatt, et al. "Identification of human CD4+ T cell populations with distinct antitumor activity." Science Advances 6, no. 27 (July 2020): eaba7443. http://dx.doi.org/10.1126/sciadv.aba7443.

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How naturally arising human CD4+ T helper subsets affect cancer immunotherapy is unclear. We reported that human CD4+CD26high T cells elicit potent immunity against solid tumors. As CD26high T cells are often categorized as TH17 cells for their IL-17 production and high CD26 expression, we posited these populations would have similar molecular properties. Here, we reveal that CD26high T cells are epigenetically and transcriptionally distinct from TH17 cells. Of clinical importance, CD26high and TH17 cells engineered with a chimeric antigen receptor (CAR) regressed large human tumors to a great

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20

Mustafa, Abu Salim, and Fredrik Oftung. "Identification of Mycobacterial Recombinant Antigens Recognized by Human T Cells." Medical Principles and Practice 6, no. 2 (1997): 57–65. http://dx.doi.org/10.1159/000157428.

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21

Allison, James P., and Lewis L. Lanier. "Identification of antigen receptor-associated structures on murine T cells." Nature 314, no. 6006 (March 1985): 107–9. http://dx.doi.org/10.1038/314107a0.

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22

Rodrigues, Olivia Roos, Cláudia Marques, Marta Soares-Clemente, Maria Helena Ferronha, and Gabriela Maria Santos-Gomes. "Identification of regulatory T cells during experimental Leishmania infantum infection." Immunobiology 214, no. 2 (February 2009): 101–11. http://dx.doi.org/10.1016/j.imbio.2008.07.001.

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23

Goh, Shan, Daniel Ngugi, Regina Lizundia, Isabel Hostettler, Kerry Woods, Keith Ballingall, Niall D. MacHugh, et al. "Identification of Theileria lestoquardi Antigens Recognized by CD8+ T Cells." PLOS ONE 11, no. 9 (September 9, 2016): e0162571. http://dx.doi.org/10.1371/journal.pone.0162571.

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24

Zimring, James C., and Judith A. Kapp. "Identification and Characterization of CD8⁺ Suppressor T Cells." Immunologic Research 29, no. 1-3 (2004): 303–12. http://dx.doi.org/10.1385/ir:29:1-3:303.

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25

GEISLER, C., J. K. LARSEN, and T. PLESNER. "Identification of alphabeta and gammadelta T Cell Receptor-Positive Cells." Scandinavian Journal of Immunology 28, no. 6 (December 1988): 741–45. http://dx.doi.org/10.1111/j.1365-3083.1988.tb01508.x.

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26

MILLER, G. G., and W. J. STRITTMATTER. "Identification of Human T Cells that Require Zinc for Growth." Scandinavian Journal of Immunology 36, no. 2 (August 1992): 269–77. http://dx.doi.org/10.1111/j.1365-3083.1992.tb03099.x.

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27

Auberson, Yves P., Emmanuelle Briard, Bettina Rudolph, Klemens Kaupmann, Paul Smith, and Berndt Oberhauser. "PET Imaging of T Cells: Target Identification and Feasibility Assessment." ChemMedChem 13, no. 15 (July 2, 2018): 1566–79. http://dx.doi.org/10.1002/cmdc.201800241.

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28

Buchwalow, Igor, Dmitri Atiakshin, Vera Samoilova, Werner Boecker, and Markus Tiemann. "Identification of autofluorescent cells in human angioimmunoblastic T-cell lymphoma." Histochemistry and Cell Biology 149, no. 2 (December 2, 2017): 169–77. http://dx.doi.org/10.1007/s00418-017-1624-y.

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29

Michalek, Jaroslav, Darina Ocadlikova, Lenka Zahradova, Lucie Kovarova, Miroslav Penka, and Roman Hajek. "Identification and Expansion of Myeloma-Specific Cytotoxic T Cells In Vitro." Blood 106, no. 11 (November 16, 2005): 5138. http://dx.doi.org/10.1182/blood.v106.11.5138.5138.

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Abstract Multiple myeloma (MM) has been considered as low immunogenic incurable disease. The attempts has been made to invert the immune status to recognize myeloma cells by T cells or other cells of the immune system. Here we studied biology of myeloma-specific T cells in vitro. Irradiated myeloma cell line ARH 77 has been used as tumor antigen to stimulate peripheral blood mononuclear cells (PBMC) of 8 healthy volunteers. Dendritic Cells loaded by irradiated autologous MM cells has been used to stimulate PBMC of 10 MM patients. Activated responder T cells have been immunomagnetically separat

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30

Zhu, Yuwen, Alessandro Paniccia, Alexander C. Schulick, Wei Chen, Michelle R. Koenig, Joshua T. Byers, Sheng Yao, Shaun Bevers, and Barish H. Edil. "Identification of CD112R as a novel checkpoint for human T cells." Journal of Experimental Medicine 213, no. 2 (January 11, 2016): 167–76. http://dx.doi.org/10.1084/jem.20150785.

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T cell immunoglobulin and ITIM domain (TIGIT) and CD226 emerge as a novel T cell cosignaling pathway in which CD226 and TIGIT serve as costimulatory and coinhibitory receptors, respectively, for the ligands CD155 and CD112. In this study, we describe CD112R, a member of poliovirus receptor–like proteins, as a new coinhibitory receptor for human T cells. CD112R is preferentially expressed on T cells and inhibits T cell receptor–mediated signals. We further identify that CD112, widely expressed on antigen-presenting cells and tumor cells, is the ligand for CD112R with high affinity. CD112R compe

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31

Surh, Charles D. "Homeostasis of Mature T Cells." Blood 112, no. 11 (November 16, 2008): sci—24—sci—24. http://dx.doi.org/10.1182/blood.v112.11.sci-24.sci-24.

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Abstract The overall size and composition of the mature T cell pool is regulated by homeostatic mechanisms. A hallmark of homeostatic regulation is the ability of the T cells to undergo spontaneous “homeostatic” proliferation in response to severe lymphopenia. By defining the factors that drive such homeostatic proliferation, we have determined that homeostasis of naïve and memory T cells is controlled by signals from contact with self-MHC/peptide ligands and/or two cytokines, namely IL-7 and IL-15. In addition, we have recently described a simple and highly effective way to administer IL-2,

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32

Morawski, Peter A., Thomas Duhen, Maria M. Klicznik, Barbara Hoellbacher, Samantha Motley, Daniel J. Campbell, and Iris K. Gratz. "Identification of functionally unique CD4 T cells that are the circulating counterparts of epidermal resident memory T cells." Journal of Immunology 200, no. 1_Supplement (May 1, 2018): 173.1. http://dx.doi.org/10.4049/jimmunol.200.supp.173.1.

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Abstract As a barrier organ, the skin contains specialized T cell populations that combat infection and also help maintain tissue homeostasis and promote wound repair. Circulating skin-tropic T cells can also be identified in the blood based on their expression of the cutaneous lymphocyte antigen (CLA), but the developmental and functional relationships between these circulating CLA+ T cells and tissue-resident T cells in the skin are not fully understood. Using 33-parameter Cytometry by time-of-flight (CyTOF) analysis we identified a novel population of skin-tropic CD4+ T cells in human blood

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33

Ogura, Hideki, Paula Preston-Hurlburt, Ana Luisa Perdigoto, Matthew Amodio, Smita Krishnaswamy, Pamela Clark, Hua Yu, et al. "Identification and Analysis of Islet Antigen–Specific CD8+ T Cells with T Cell Libraries." Journal of Immunology 201, no. 6 (August 6, 2018): 1662–70. http://dx.doi.org/10.4049/jimmunol.1800267.

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34

Hoog, Anna, Sonia Villanueva-Hernández, Mahsa Adib Razavi, Katinka van Dongen, Thomas Eder, Lauriane Piney, Ludivine Chapat, et al. "Identification of CD4+ T cells with T follicular helper cell characteristics in the pig." Developmental & Comparative Immunology 134 (September 2022): 104462. http://dx.doi.org/10.1016/j.dci.2022.104462.

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35

Stein, H., M. Sperling, D. Dienemann, M. Zeitz, and E. O. Riecken. "IDENTIFICATION OF A T CELL LYMPHOMA CATEGORY DERIVED FROM INTESTINAL-MUCOSA-ASSOCIATED T CELLS." Lancet 332, no. 8619 (November 1988): 1053–54. http://dx.doi.org/10.1016/s0140-6736(88)90068-2.

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36

Au, Sam H. "10,368 first dates: Microfluidic T cell matchmaking." Science Translational Medicine 10, no. 468 (November 21, 2018): eaav9144. http://dx.doi.org/10.1126/scitranslmed.aav9144.

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37

Frentsch, Marco, Regina Stark, Joanna Listopad, Sarah Meier, Axel Schulz, Sibel Durlanik, Thomas Blankenstein, and Andreas Thiel. "Identification and characterization of CD8+ T helper cells based on CD40L expression (155.1)." Journal of Immunology 186, no. 1_Supplement (April 1, 2011): 155.1. http://dx.doi.org/10.4049/jimmunol.186.supp.155.1.

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Abstract CD8+ T cells are primarily regarded as cytotoxic cells. We have identified a substantial subset of CD40L expressing non-cytotoxic T-cells among primary human CD8+ T cells. CD40L+ CD8+ T cells exert diverse characteristic Th-cell functions such as activation of B cells, induction of DC maturation and secretion of cytokines such as IL-2, IFNγ, TNFα or IL-4. Up to 25% of total human central and effector memory CD8+ T cells express CD40L including cells specific for pathogens such as influenza, CMV and EBV, as well as yellow fever virus specific cells after primary vaccination. At next we

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38

Ranes-Goldberg, M. G., T. Hori, S. Mohan-Peterson, and H. Spits. "Identification of human pre-T/NK cell-associated genes." Journal of Immunology 151, no. 10 (November 15, 1993): 5810–21. http://dx.doi.org/10.4049/jimmunol.151.10.5810.

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Abstract We have used a combination of subtractive cloning and differential screening techniques to identify genes preferentially expressed in early stages of human T/NK cell development compared with mature T and NK cells. A fetal liver-derived cytoplasmic (c) CD3+ membrane (m) CD3- clone, FL508, which expresses markers characteristic of pre-T and pre-NK cells served as a cell source for our cloning experiments. A cDNA library enriched for genes expressed in FL508 was constructed by removal of cDNA that hybridized to mRNA from a B cell line, JY. One-tenth of the resulting library of 5000 clon

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39

Bohana-Kashtan, Osnat, Hyam Levitsky, and Curt I. Civin. "Identification of New Alloantigen-Reactive CD8+ Cytotoxic and Suppressor T Cell Subpopulations." Blood 110, no. 11 (November 16, 2007): 3229. http://dx.doi.org/10.1182/blood.v110.11.3229.3229.

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We sought to develop a better understanding of the T cells involved in the human allogeneic immune response, in order to eventually engineer a donor graft with reduced GVHD-mediating potential, without ablating general immune competence. Prior studies reported that all the activated CD4+ T cells responding to a specific antigen challenge reside within the CD4high population expressing high levels of membrane CD4. We identified a new population of activated CD8+ T cells that developed during an in vitro allogeneic immune response, along with the allo-activated CD4high T cell population. Analogo

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40

Kass, L. "Identification of lymphocyte subpopulations with a polymethine dye." Journal of Histochemistry & Cytochemistry 36, no. 7 (July 1988): 711–15. http://dx.doi.org/10.1177/36.7.2454984.

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Using the polymethine dye p-ethoxyphenyl-p-aminostyryl-1,3,3-trimethyl-3H-indolium chloride as an aqueous stain applied to specimens of peripheral blood or buffy coat fixed in FAA fixative, differential coloration of leukocytes was achieved using darkfield illumination. Neutrophils stained dark maroon and contained green granules, eosinophils contained bright blue granules, basophils revealed yellow and pink granules, and monocytes stained green with green and yellow vacuoles. In studies of purified lymphocyte subpopulations obtained in a cell sorter, T-helper cells stained red, T-suppressor c

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41

Tiemann, Markus, Dmitri Atiakshin, Vera Samoilova, and Igor Buchwalow. "Identification of CTLA-4-Positive Cells in the Human Tonsil." Cells 10, no. 5 (April 27, 2021): 1027. http://dx.doi.org/10.3390/cells10051027.

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CTLA-4 (cytotoxic T-lymphocyte-associated protein 4) was originally defined as a T-lymphocyte antigen and was used as a target in cancer immunotherapy. Unfortunately, the existence of CTLA-4 in cells other than T-lymphocytes is often overlooked. The goal of the present study was to analyze the distribution pattern of CTLA-4 in the human tonsils using a panel of anti–CTLA-4 antibodies of different clones. We found that CTLA-4 was expressed in T-lymphocyte cells of various geneses, including hematopoietic cells and their derivatives (monocytes, macrophages, dendritic, plasma cells, mast cells, a

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42

Chen, C. L., L. L. Ager, G. L. Gartland, and M. D. Cooper. "Identification of a T3/T cell receptor complex in chickens." Journal of Experimental Medicine 164, no. 1 (July 1, 1986): 375–80. http://dx.doi.org/10.1084/jem.164.1.375.

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A mouse mAb, CT-3, recognizes on chicken T cells a complex of three polypeptides, Mr 20,000, 19,000, and 17,000, two of which are N-glycosylated. The CT-3 antibody is mitogenic for chicken T cells, and it coprecipitates two additional polypeptides of Mr 49,000 and 38,000 in lysates of T cell membranes. Ontogeny studies revealed that 5-6 d after thymic influx of hemopoietic stem cells, their thymocyte progeny begin to express the T3/TCR complex. After hatching 1 wk later, the CT-3+ cells begin splenic migration in large numbers.

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43

Zuckerman, L. A., A. J. Sant, and J. Miller. "Identification of a unique costimulatory activity for murine T helper 1 T cell clones." Journal of Immunology 154, no. 9 (May 1, 1995): 4503–12. http://dx.doi.org/10.4049/jimmunol.154.9.4503.

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Abstract We have examined the ability of several class II-positive tumor cell transfectants to stimulate murine Th1 clones. Most of the transfectants failed to activate the Th1 clones and, in fact, induced Ag-specific anergy. However, we found that one tumor, a UV-induced fibrosarcoma (6130-VAR1), was capable of stimulating both cytokine production and proliferation in Th1 clones. We believe that 6130-VAR1 cells possess a unique costimulatory activity for the following reasons. First, these cells fail to express known costimulatory molecules including B7-1 and B7-2. Second, 6130-VAR1-mediated

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Lightstone, Liz, and Jacqueline Marvel. "CD45RA+ T Cells: Not Simple Virgins." Clinical Science 85, no. 5 (November 1, 1993): 515–19. http://dx.doi.org/10.1042/cs0850515.

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1. The T cells which mediate immunological memory remain elusive. Identification of such cells would open the door to increasingly specific immunotherapy in areas such as transplantation and autoimmunity. 2. Over the last few years attempts have been made to identify phenotypic markers which can distinguish naive or virgin T cells from primed or memory ones. In humans, great hopes were raised when it was shown that the level of expression of the higher-molecular-mass isoforms (CD45RA) of the tyrosine phosphatase, CD45, correlated with previous exposure to antigen. 4. However, our studies in th

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Kang, Chung Hyo, Yeongrin Kim, Heung Kyoung Lee, So Myoung Lee, Hye Gwang Jeong, Sang Un Choi, and Chi Hoon Park. "Identification of Potent CD19 scFv for CAR T Cells through scFv Screening with NK/T-Cell Line." International Journal of Molecular Sciences 21, no. 23 (December 1, 2020): 9163. http://dx.doi.org/10.3390/ijms21239163.

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CD19 is the most promising target for developing chimeric-antigen receptor (CAR) T cells against B-cell leukemic cancer. Currently, two CAR-T-cell products, Kymriah and Yescarta, are approved for leukemia patients, and various anti-CD19 CAR T cells are undergoing clinical trial. Most of these anti-CD19 CAR T cells use FMC63 single-chain variable fragments (scFvs) for binding CD19 expressed on the cancer cell surface. In this study, we screened several known CD19 scFvs for developing anti-CD19 CAR T cells. We used the KHYG-1 NK/T-cell line for screening of CD19 scFvs because it has advantages i

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Chavarria, Melina, Jessica Vazquez, and Aleksandar Stanic-Kostic. "Identification of MAIT Cells in Human Term Decidua." Journal of Immunology 198, no. 1_Supplement (May 1, 2017): 149.4. http://dx.doi.org/10.4049/jimmunol.198.supp.149.4.

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Abstract Mucosal-associated invariant T (MAIT) cells are a CD161+Vα7+ MR1-restricted T-cell subset, that has a complex relationship in regulating the microbiome and defense from invasive bacteria. Recent discovery of a placental microbiome, and genital mucosa MAIT cells, raises the possibility that MAIT are present at the maternal fetal interface and perform regulatory functions in this setting. As a first step, we analyzed human term decidua to detect MAIT cells and analyze their transcriptional programming. Decidua was dissected from human term placentas and mononuclear cells (MCs) were isol

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Bedke, Tanja, Sarah Lurati, Claudia Stuehler, Nina Khanna, Hermann Einsele, and Max S. Topp. "Identification and Characterization of Human Aspergillus Fumigatus-Specific Tr1-(Like) Cells." Blood 118, no. 21 (November 18, 2011): 181. http://dx.doi.org/10.1182/blood.v118.21.181.181.

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Abstract Abstract 181 Introduction: The ubiquitous mold Aspergillus fumigatus (A. fumigatus) induces two forms of pathogenesis: invasive aspergillosis in neutropenic patients and allergic aspergillosis in patients with chronic obstructive lung disease as well as in immunosuppressed patients. Mouse models of aspergillosis suggest that not only effector T cells (Teff) but also regulatory T cells (Treg) play a crucial role for the regulation of a protective T cell-mediated immunity to A. fumigatus. However, it is little-known about the involvement of Treg during A. fumigatus infection in humans.

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Fujiki, Tsukasa, Ryosuke Shinozaki, Miyako Udono, and Yoshinori Katakura. "Identification and Functional Evaluation of Polyphenols That Induce Regulatory T Cells." Nutrients 14, no. 14 (July 13, 2022): 2862. http://dx.doi.org/10.3390/nu14142862.

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Regulatory T cells (Tregs) and CD4+/CD25+ T cells play an important role in the suppression of excessive immune responses, homeostasis of immune function, and oral tolerance. In this study, we screened for food-derived polyphenols that induce Tregs in response to retinaldehyde dehydrogenase (RALDH2) activation using macrophage-like THP-1 cells. THP-1 cells were transfected with an EGFP reporter vector whose expression is regulated under the control of mouse Raldh2 promoter and named THP-1 (Raldh2p-EGFP) cells. The THP-1 (Raldh2p-EGFP) cells were treated with 33 polyphenols after inducing their

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Dahl, C. A., R. P. Schall, H. L. He, and J. S. Cairns. "Identification of a novel gene expressed in activated natural killer cells and T cells." Journal of Immunology 148, no. 2 (January 15, 1992): 597–603. http://dx.doi.org/10.4049/jimmunol.148.2.597.

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Abstract We have isolated a cDNA clone from a human activated NK cell-derived cDNA library that identifies a transcript (NK4) that is selectively expressed in lymphocytes. The expression of this transcript is increased after activation of T cells by mitogens or activation of NK cells by IL-2 (lymphokine-activated killer cells). The transcript levels demonstrated by Northern blot analysis increase by 12 h after activation, remain high for at least 48 h, and require protein synthesis for expression. Southern blot analysis of B lymphoblastoid lines derived from 18 unrelated individuals reveal var

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Tilden, A. B., K. Itoh, and C. M. Balch. "Human lymphokine-activated killer (LAK) cells: identification of two types of effector cells." Journal of Immunology 138, no. 4 (February 15, 1987): 1068–73. http://dx.doi.org/10.4049/jimmunol.138.4.1068.

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Abstract We analyzed the antigenic phenotype of lymphokine-activated killer (LAK) effector cells. Human blood lymphocytes were cultured for 3 days with 100 U/ml recombinant interleukin 2 (rIL 2), subpopulations isolated with monoclonal antibodies and a fluorescence-activated cell sorter (FACS) and assayed for cytotoxic activity against 51chromium labeled noncultured melanoma tumor cells. Initial experiments compared the LAK effector function of CD5+ T lymphocytes vs CD5- cells (predominantly CD16+ NK cells). The mean percent specific release at a 10:1 effector:target (E:T) ratio was 25% +/- 16

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