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Dissertations / Theses on the topic 'T cells Receptors'

Author: Grafiati

Published: 4 June 2021

Last updated: 6 September 2023

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1

Soper, David Michael. "Interleukin-2 receptor and T cell receptor signaling in regulatory T cells /." Thesis, Connect to this title online; UW restricted, 2007. http://hdl.handle.net/1773/8344.

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2

Carson, Bryan David. "Impaired T cell receptor signaling in regulatory T cells /." Thesis, Connect to this title online; UW restricted, 2006. http://hdl.handle.net/1773/8337.

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3

Ebert, Lisa Michelle. "The regulation of chemokine receptor expression upon T lymphocyte activation." Title page, contents and abstract only, 2002. http://web4.library.adelaide.edu.au/theses/09PH/09phe165.pdf.

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4

Parra, Eduardo. "Molecular basis for costimulation of human T lymphocytes." Lund : Lund University, 1998. http://books.google.com/books?id=SgFrAAAAMAAJ.

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5

Carlsson, Fredrik. "Antibody Feedback Regulation and T Cells." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7631.

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6

Tanaka, Yujiro. "Selection of T cells in the thymus." Thesis, University College London (University of London), 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.294749.

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7

Chan, Ping-lung, and 陳秉隆. "Roles of TLR5 and ICOS on the human allogenic CD40-activated B cell-induced CD4hiCD25+ regulatory T cells." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B47149735.

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8

Neeraj. "Studies on equine helper T cells and Fcγ receptors". Thesis, University of Cambridge, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.627077.

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9

Crocker, Glenn. "A study of surface receptors on rat T lymphocytes." Thesis, University of Oxford, 1991. http://ora.ox.ac.uk/objects/uuid:5c74a70b-1f5e-4c78-904f-7c4ff1b543a8.

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A double immunolabelling technique was developed to study microscopically the interactions between CD4, CD45 and the T cell receptor on the surface of rat T cells induced by the phenomenon of co-capping. It was found that both CD4 and CD45 passively co-cap with the actively capped T cell receptor, that the T cell receptor and CD45 passively co-cap with CD4, but that neither CD4 nor the T cell receptor co-cap with CD45. Co-crosslinking and active capping of CD45 with either the T cell receptor or CD4 prevented CD4 or the T cell receptor respectively, from passively co-capping. These experiments

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10

Jiang, Ning. "Kinetic analysis of Fcγ receptor and T cell receptor interacting with respective ligands". Diss., Georgia Institute of Technology, 2005. http://hdl.handle.net/1853/26716.

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Low affinity Fcg receptor III (FcgRIII, CD16) triggers a variety of cellular events upon binding to the Fc portion of IgG. A real-time flow cytometry method was developed to measure the affinity and kinetics of such low affinity receptor/ligand interactions, which was shown as an easily operated yet powerful tool. Results revealed an unusual temperature dependence of reverse rate of CD16aTM dissociating from IgG. Except for a few studies using mammalian cell CD16s, most kinetics analyses use purified aglycosylated extracellular portion of the molecules, making it impossible to assess the impor

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11

Wikstrom, Matthew E. "The regulation of peripheral T cell responses in TCR transgenic mice." Thesis, The University of Sydney, 1997. https://hdl.handle.net/2123/27641.

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Transgenic mice expressing a T cell receptor specific for cytochrome C in association with I-Ek were employed to study the mechanisms regulating the decision between tolerance and immunity. Tolerance and immunity to the same peptide antigen were . induced by using different routes of administration. Thus tolerance was induced by the intravenous route and immunity by the subcutaneous route. The results presented in this thesis provide a detailed map of the cellular events that occur during these two distinct responses. Intravenous immunisation induced activation of CD4+ cells expressin

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12

Wang, Aibo. "Phosphorylation of Nur77 by MEK-ERK-RSK cascade induces mitochondrial translocation and apoptosis in T cells." Amherst, Mass. : University of Massachusetts Amherst, 2009. http://scholarworks.umass.edu/dissertations/AAI3372283/.

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13

Cowan, Teresa. "The TCRBJ and TCRBV repertoire in naive and memory human T-cells." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp01/MQ34173.pdf.

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14

Sandalova, Elena. "Regulation of the pro-apoptotic protein bim by T cell receptor triggering in human T cells /." Stockholm, 2007. http://diss.kib.ki.se/2007/978-91-7357-041-1/.

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15

Morrison, Vicky L. "Innate and cognate roles of B cells in T cell differentiation and memory." Thesis, University of Edinburgh, 2011. http://hdl.handle.net/1842/4873.

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B cells recognise antigens on micro-organisms through their B cell receptor (BCR) and via Toll-like receptors (TLRs), and thus respond in both innate and adaptive manners during the subsequent immune response. Innate recognition through TLRs has the potential to alter the behaviour of whole B cell populations. I show, here, that MyD88-dependent activation of B cells via TLR2 or TLR9 causes the rapid loss of expression of CD62L, by metalloproteinasedependent shedding, resulting in the exclusion of these cells from lymph nodes and Peyer’s patches, but not the spleen. Moreover, systemic infection

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16

Vessey, S. J. R. "A molecular analysis of the T-cell receptor." Thesis, University of Oxford, 1997. http://ora.ox.ac.uk/objects/uuid:87b560f9-b1d6-4b12-9c94-fd1b4de397f6.

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The recognition of MHC-peptide ligands by the T cell receptor (TCR) is central to the induction of the adaptive immune response. This thesis describes the development of a bioassay for TCR recognition which was then used to undertake a molecular analysis of the TCR/MHC-peptide interaction. 1. A TCR-CD3ϛ chimeric receptor was stably expressed in the cell line RBL-2H3 to give the transfectant RBL-008. RBL-008 was shown to exhibit MHC-restricted peptide-specific responses to both cellular and multimerised recombinant HLA-A2-pol peptide targets (Chapter 3). 2. By competitively inhibiting the respo

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17

Gray, Daniel Herbert Donald. "Thymic stromal cells : population dynamics and their role in thymopoiesis." Monash University, Dept. of Pathology and Immunity, 2003. http://arrow.monash.edu.au/hdl/1959.1/9409.

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18

Wallace, Zoë R. "Application of engineered T cell receptors to investigate the failure of cytotoxic T lymphocytes to eliminate the HIV reservoir." Thesis, University of Oxford, 2017. https://ora.ox.ac.uk/objects/uuid:a7b1d93d-2637-4197-b18a-726d96352043.

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HIV establishes a reservoir comprising long lived, latently infected CD4+ T cells and monocytic cells early during primary infection. This population represents a major barrier to an HIV cure. This thesis aimed to investigate the role of the immunological synapse in the failure of cytotoxic T lymphocytes (CTLs) to eliminate the HIV reservoir and the potential for engineered bispecific <b>I</b>mmune-<b>m</b>obilising <b>m</b>onoclonal <b>T</b> cell receptors <b>A</b>gainst <b>V</b>iruses (ImmTAV) to overcome this by redirecting fully functional CD8+ T cells against viral targets. A primary cell

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19

Kwong, Pearl Chu. "Characterization of an antigen-specific T helper cell clone and its products." Thesis, University of British Columbia, 1987. http://hdl.handle.net/2429/27366.

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A T helper cell clone, referred to as clone 9, was derived from an allogeneic mixed lymphocyte culture. Clone 9, as well as supernatant factor(s) derived from it, could help the cytotoxic T lymphocyte (CTL) responses of H-2 Db (Db) responder cells to alloantigens, or they could help the CTL responses of non- Db responder cells to Db alloantigens. Clone 9 cells or their factor(s) were active only when added during the first 24 hours of a five-day culture period. Clone 9 or its factor(s) could also synergize with interleukin-2 (IL-2)-containing medium in mounting cytotoxic responses to alloantig

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20

Galperin, Moran. "Molecular and functional characterization of high avidity T cell receptors preferentially expressed by HIV-specific CD4 + T cells from HIV controllers." Sorbonne Paris Cité, 2015. http://www.theses.fr/2015USPCC251.

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Les « HIV controllers » (HICS) sont de rares patients qui contrôlent spontanément la réplication du VIH en absence de thérapie antirétrovirale. Ces patients sont caractérisés par un taux normal de Cellules T CD4+ et le maintien d'une charge virale indétectable (< 50 copies d'ARN viral / ml de plasma), et montrent un très faible risque de progression vers le sida, de nombreux travaux suggèrent que le contrôle de la réplication virale chez ces patients est dû à une réponse cellulaire antivirale. Particulièrement efficace, notre équipe a montré que ces hics maintiennent des réponses T CD4+ trè

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21

Wong, Yin-ling. "The effects of respiratory syncytial virus on alveolar epithelial cells toll-like receptors expressions and T cell apoptosis." Click to view the E-thesis via HKUTO, 2009. http://sunzi.lib.hku.hk/hkuto/record/B4218230X.

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22

Sáez, Borderias Andrea. "Regulation of natural killer and cd4+T cell function by NKG2 C-type lectin-like receptors." Doctoral thesis, Universitat Pompeu Fabra, 2009. http://hdl.handle.net/10803/7133.

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This work is centered on the study of the NKG2 C-type lectin-like receptors on NK and CD4+T cells. We provide evidence supporting that CD4+T cells specific for Human Cytomegalovirus (HCMV) may express different NK cell receptors, and demonstrate that the C-type lectin-like receptor NKG2D is expressed on cytotoxic CD4+T cells with an effector/memory phenotype, enhancing their TCR-dependent proliferation and cytokine production. A second part of the work is centered on the study of the CD94/NKG2 receptors on NK cells. We show that NKG2A can be induced on NKG2C+ NK cells upon activation with rIL-

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23

Goldrath, Ananda W. "T cell homeostasis : a role for specific peptide/MHC ligands in homeostasis driven proliferation of naive CD8⁺ T cells /." Thesis, Connect to this title online; UW restricted, 2000. http://hdl.handle.net/1773/8332.

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24

Khan, Nouman Ullah. "The effect of chemokines on T regulatory cells following heart transplantation." Thesis, University of Manchester, 2011. https://www.research.manchester.ac.uk/portal/en/theses/the-effect-of-chemokines-on-t-regulatory-cellsfollowing-heart-transplantation(6b5b194d-f2fd-4869-9b22-95ce099ac3ed).html.

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Heart transplantation (HTx) is now an established therapy for end-stage cardiac failure not responding to medical treatment. Recent decades have seen improved outcome following HTx due to more effective and targeted immunosuppressive therapy. However, acute and chronic rejection remains a major cause of morbidity and mortality. At the same time, immunosuppressive strategies are associated with significant side effects, including development of tumours. Hence, the induction of immunologic tolerance to alloantigen is considered the “holy grail” of transplant research. T regulatory cells (Tregs)

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25

Bento, Rui Pedro Garcia de Oliveira. "CAR-modified T cells targeted to CD19 antigen for lymphocytic leukemia." Master's thesis, Universidade de Aveiro, 2014. http://hdl.handle.net/10773/13445.

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Mestrado em Biomedicina Farmacêutica<br>Cellular immunotherapies, or Advanced Therapy Medicinal Products (ATMPs), are emerging as novel and specific therapeutic approaches to treat diseases, such as certain types of leukemias, which are difficult or impossible to treat with today’s biopharmaceutical products. Breakthroughs in basic, preclinical, and clinical science spanning cellular immunology, and cellprocessing technologies has allowed clinical applications of chimeric antigen receptor–based therapies. A recent example is CTL019, a lentivirus-based gene therapy for autologous T cells, acqui

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26

Wong, Yin-ling, and 王燕玲. "The effects of respiratory syncytial virus on alveolar epithelial cells toll-like receptors expressions and T cell apoptosis." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B4218230X.

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27

Lee, James C. "Inventing New CARs: Analysis of Chimeric Antigen Receptor Gene-Targeted T cells Modified to Overcome Regulatory T cell Suppression in the Tumor Microenvironment." Yale University, 2009. http://ymtdl.med.yale.edu/theses/available/etd-03052009-202819/.

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Human T cells may be genetically modified to express targeted chimeric antigen receptors (CARs). We have previously demonstrated that T cells modified to express a CAR specific to the B cell tumor antigen CD19, termed 19-28z, successfully eradicate systemic human CD19+ tumors in SCID-Beige mice. While these results are encouraging, this xenogeneic tumor model fails to address potential limitations of this therapeutic approach in the clinical setting wherein these modified T cells encounter a hostile tumor microenvironment. Specifically, these models fail to address potential effector T cell in

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28

Edmunds, Catherine. "A study of PI3K regulation by costimulatory and inhibitory receptors in T and B lymphocytes." Thesis, University of Bath, 2000. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.341105.

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29

Asad, Suzanne. "Expression of Trafficking Receptors by Regulatory T Cells in Human Health and Autoimmune Disease." Thesis, The University of Sydney, 2016. http://hdl.handle.net/2123/16442.

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Abnormalities in CD4+CD25+CD127loFoxP3+ regulatory T cells (Tregs) have been implicated in susceptibility to autoimmune disease. To define migratory Treg subsets that may be implicated in the pathogenesis of diseases manifested in different tissues, we designed 11 and 13 colour flow-cytometry panels to measure the expression of a range of chemokine receptors and integrins on Tregs in the peripheral blood (PB) of healthy individuals (n=44) and patients with rheumatoid arthritis (RA) (n=34) or psoriasis (n=44). We showed that CLA, CCR4, CCR5, CCR6, CCR10 and CD62L were expressed on a higher prop

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30

Iaboni, Andrea. "An evolutionary and functional analysis of the extended B7 family of costimulatory molecules." Thesis, University of Oxford, 2002. http://ora.ox.ac.uk/objects/uuid:e769d4ab-81c9-4f92-918f-8ddfb718b596.

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31

Teixeira, de Matos Cristina. "Modulation of natural killer cell and T-cell functions by CD94/NKG2A receptors /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-846-0/.

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32

DeVault, Victoria. "Regulation Of Natural Killer T Cell Subset Development And Function By Slam Family Receptors." ScholarWorks @ UVM, 2019. https://scholarworks.uvm.edu/graddis/990.

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Semi-invariant natural killer T (iNKT) cells are critical components of the host immune response in peripheral tissues such as the lung, liver, and gut, and they play important roles in cancer, bacterial infections, autoimmunity, wound repair, and atherosclerosis. Tissue-resident iNKT cells exert their effects early in the developing immune response by rapidly producing a wide variety of cytokines and chemokines, and it was recently discovered that different tissues possess iNKT cell subsets that preferentially produce IFN-γ (NKT1), IL-4 (NKT2), or IL-17 (NKT17). Despite their critical role in

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33

Karlsson, Hannah. "CD19-targeting CAR T Cells for Treatment of B Cell Malignancies : From Bench to Bedside." Doctoral thesis, Uppsala universitet, Klinisk immunologi, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-232638.

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Immunotherapy for cancer is a young research field progressing at high speed. The first chimera of an antibody and a signaling chain was designed by Zelig Eshhar and was later further developed to enhance existing T cell therapy by combining a single-chain fragment of an antibody with the CD3 zeta chain of the TCR complex. T cells expressing these chimeric antigen receptors (CARs) could recognize and specifically kill tumor cells. However the T cells, lacked in persistence and tumor rejection did not occur. Thus, the CAR constructs have been improved by providing the T cell with costimulatory

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34

Hossain, Md Kamal. "Targeting Fc Receptors for More Effective Cancer Vaccines." University of Toledo Health Science Campus / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=mco1544800037742347.

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35

Simmons, Daimon P. "Effects of Toll-Like Receptors and Type I Interferon on Dendritic Cell Maturation and Activation of T Cells." Case Western Reserve University School of Graduate Studies / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=case1311278278.

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36

Dossett, Michelle Leigh. "Generation and expression of high affinity, tumor antigen-specific mouse and human T cell receptors to genetically modify CD8⁺ T cells for adoptive immunotherapy of cancer /." Thesis, Connect to this title online; UW restricted, 2006. http://hdl.handle.net/1773/8316.

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37

Nikitin, Artemii. "Role of nuclear receptor RORα in regulatory T cells". Thesis, Université de Lille (2018-2021), 2019. http://www.theses.fr/2019LILUS073.

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Les facteurs de transcription de la superfamille des récepteurs nucléaires jouent de multiples rôles dans le développement et la fonction des lymphocytes T régulateurs (TREG). Les TREG sont des cellules régulatrices/suppressives qui contrôlent les réponses d’autres types cellulaires et l’homéostasie locale des tissus.Comme les TREG sont actives au sein de divers organes, tant à l’homéostasie qu’en conditions inflammatoires,ils doivent répondre à la fois aux contexte local au sein du tissus et à un environnement immunologiquement agressif tout en préservant leurs propriétés tolérogéniques au co

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38

Vas, Jaya. "REGULATORY ROLES FOR NATURAL KILLER T CELLS AND TOLL-LIKE RECEPTORS IN MERCURY-INDUCED AUTOIMMUNITY." Diss., Temple University Libraries, 2008. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/20283.

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Microbiology and Immunology<br>Ph.D.<br>The development of autoimmune diseases is frequently linked to exposure to environmental factors such as chemicals, drugs or infections. In the experimental model of metal-induced autoimmunity, administration of subtoxic doses of mercury (a common environmental pollutant) to genetically susceptible mice induces an autoimmune syndrome with rapid anti-nucleolar antibody production and immune system activation. Regulatory components of the innate immune system such as NKT cells and TLRs can also modulate the autoimmune process. We examined the interplay amo

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39

Skarsvik, Susanne. "Aberrancies associated with dendritic cells and T lymphocytes in type 1 diabetes /." Linköping : Linköpings universitet, 2005. http://www.bibl.liu.se/liupubl/disp/disp2005/med920s.pdf.

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40

Souza, Luciana Bento de. "Avaliação da expressão de receptores e ligantes Notch nas populações de linfócitos T em desenvolvimento, linfócitos T reguladores naturais e células dendríticas no timo humano." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/5/5144/tde-27112012-102148/.

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O timo é o órgão linfóide primário responsável pela maturação dos linfócitos T onde se observam estruturas e células especializadas. A sinalização intra-tímica durante a maturação de linfócitos T não é bem esclarecida. Entre outras, a via de sinalização Notch, composta por receptores (Notch 1 a 4) e ligantes (DLL1, 3 e 4, Jagged 1 e 2), pode regular este processo. Neste trabalho temos como objetivo avaliar a expressão gênica e proteica de receptores e ligantes Notch nas diferentes fases de maturação de linfócitos T, linfócitos T reguladores naturais (nTreg) e células dendriticas tímicas (tDC).

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41

Barton, Gregory Methven. "Positive selection of CD4 T cells by specific peptide-MHC class II complexes /." Thesis, Connect to this title online; UW restricted, 2000. http://hdl.handle.net/1773/4994.

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42

Chau, Suk-yi, and 周淑怡. "A study of the expression of Sonic hedgehog and its receptors in T cells and the identification of Sonic hedgehog dowm-stream targets inactivated CD4+T cells." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2004. http://hub.hku.hk/bib/B31386234.

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43

Berger, DeAnna L. "Investigation of the role of CD137 (4-1BB) costimulation in human CD8⁺ T cell responses." Free to MU Campus, others may purchase, 2004. http://wwwlib.umi.com/cr/mo/fullcit?p1421114.

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44

Weigand, Luise [Verfasser], Heinrich H. D. [Akademischer Betreuer] Meyer, and Angela [Akademischer Betreuer] Krackhardt. "Characterization of human MHC II-restricted T cell receptors with reactivity against B cells and tumor cells for therapeutic application in the context of adoptive T cell transfer of transgenic CD4 T cells / Luise Weigand. Gutachter: Angela Krackhardt ; Heinrich H. D. Meyer. Betreuer: Heinrich H. D. Meyer." München : Universitätsbibliothek der TU München, 2011. http://d-nb.info/1016727798/34.

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45

Chau, Suk-yi. "A study of the expression of Sonic hedgehog and its receptors in T cells and the identification of Sonic hedgehog dowm-stream targets in activated CD4+T cells." Click to view the E-thesis via HKUTO, 2004. http://sunzi.lib.hku.hk/hkuto/record/B31386234.

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46

Öberg, Linda. "Influence of Ly49 inhibitory receptors and MHC class I on T cell and NK cell function /." Stockholm : Karolinska institutet, 2005. http://diss.kib.ki.se/2005/91-7140-217-9/.

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47

Hjelm, Fredrik. "Early Immunostimulatory Effects of IgE- and IgG Antibodies." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7209.

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48

Halford, Emily Elisabeth. "The role of group 3 innate lymphoid cells and tumour necrosis factor receptors in the survival and function of regulatory T cells." Thesis, University of Birmingham, 2016. http://etheses.bham.ac.uk//id/eprint/6679/.

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The ability to therapeutically manipulate regulatory T (Treg) cell survival/function would have far reaching implications; with the potential to limit immune pathology in autoimmune disease, allergy and transplantation; and to reduce regulation of anti-tumour responses in cancer. This study has established a method to study the survival and function of antigen specific Treg cells in vivo, adapting an existing approach in which an endogenous naïve T cell population is expanded and tracked. Multiple immunisation of antigen, and an agonistic anti-DR3 antibody were used to ensure a sufficient numb

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49

Shen, Zu T. "Molecular Studies of T Cell Recognition and Cross-Reactivity: A Dissertation." eScholarship@UMMS, 2012. https://escholarship.umassmed.edu/gsbs_diss/630.

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Intracellular pathogens are recognized by a specialized subset of lymphocytes known as CD8+ T cells. Pathogen recognition by CD8+ T cells occurs through binding of T cell receptors (TCR) to processed antigens in complex with major histocompatibility complex (MHC) class I proteins. TCR engagement of antigens in complex with MHC class I typically lead to cytotoxic CD8+ T cell responses, which result in pathogen clearance. Due to the large number of foreign antigens that might be encountered by any given host a diverse repertoire of TCRs must be available for immune recognition. The main source o

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50

Gozalo, Sara. "The Role of γ_с Cytokines in T Cell Development, T Cell Homeostasis and CD8+ T Cell Function: A Dissertation". eScholarship@UMMS, 2004. https://escholarship.umassmed.edu/gsbs_diss/140.

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T lymphocytes are essential components of the immune system and as such are continually regulated by a variety of factors. Every step of their development, survival and function is tightly monitored to ensure their ability to recognize most foreign agents and mount adaptive immune responses during pathogenic infections, while remaining tolerant to self-antigens. Among the many factors that participate in the regulation of T cell development and function are the cytokines. Cytokines that signal through the common gamma (γс) chain and the Janus kinase 3 (Jak3) include IL-2, -4, -7, -9, -15, and

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