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Dissertations / Theses on the topic 'T-dependent'

Author: Grafiati

Published: 4 June 2021

Last updated: 20 February 2023

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1

Pido, Jeffrey. "Factors affecting thymic-dependent T cell reconstitution." Thesis, Imperial College London, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.406587.

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2

Cobb, Dustin. "T-bet-dependent regulation of T cell responses during Trypanosoma cruzi infection." VCU Scholars Compass, 2012. http://scholarscompass.vcu.edu/etd/372.

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The human pathogen Trypanosoma cruzi is an intracellular parasite and the etiological agent of Chagas disease. Protective immune responses to T. cruzi are highly dependent on T helper 1 and CD8+ T cells which produce interferon-gamma. A deficiency in these responses has severe consequences on the ability to control infection. Our investigation into the role of the Th1 transcription factor, T-bet, during murine T. cruzi infection revealed that T-bet is required for resistance. Contrary to our expectations, T-bet was not required for the development of Th1 immunity during infection, as T-bet

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3

Long, Tianying. "Autoaggressive T cells in insulin-dependent diabetes mellitus." Thesis, McGill University, 1990. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=60429.

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Considerable evidence suggests that insulin-dependent diabetes mellitus (IDDM) is a T cell-mediated autoimmune process that is directed against antigenic target(s) on pancreatic $ beta$ cells. To better understand T cell involvement in the pathogenesis of IDDM, a panel of T cell hybridomas were produced from pancreas-derived T cells of spontaneously diabetic NOD mice. A total of 119 hybridomas were constructed from 8 fusions and 94 of these were tested. Twelve hybridomas were found to be islet-reactive since they produced high level of interleukin-2 (IL-2) in the presence of NOD islet cells an

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4

Zarozinski, Christopher C. "T Cell Receptor-Dependent and Independent Events During Potent Anti-Viral T Cell Responses." eScholarship@UMMS, 1998. http://escholarship.umassmed.edu/gsbs_diss/175.

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The relative contribution of T cell receptor-dependent stimulation versus TcR-independent bystander stimulation in the massive increase in the number of activated proliferating CD8+ T cells seen during acute many acute viral infections is unclear. To determine if this increase was the result of TcR-independent bystander activation and proliferation, anti-viral cytotoxic T lymphocytes were induced in vivo via DNA immunization so that the anti-viral immune response could be examined in the absence of the high levels of cytokines generated during acute infection. After a single immunization with

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5

English, Kieran. "Deciphering the cellular mechanisms promoting CD4+ T cell-dependent intrahepatic CD8+ T cell immunity." Thesis, The University of Sydney, 2022. https://hdl.handle.net/2123/27735.

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The liver is the body’s largest internal organ and assumes many important physiological and metabolic functions. It is also well-established that the liver possesses unique immunological properties and a delicate balance between tolerance and immunity exists within this large organ. CD4 T cell help to CD8 T cells has emerged as a critical factor involved in promoting robust CD8 T cell responses against viral and tumour antigens. Studies in humans and chimpanzees indicate that CD4 T cells are critical for strong intrahepatic CD8 T cell responses and the spontaneous control of hepatitis C virus

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6

Camoglio, Luisa. "IL-12 and T-lymphocyte dependent mucosal immune responses." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2000. http://dare.uva.nl/document/82609.

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7

Wang, Shu-Fang. "Development of Notch-dependent T-cell leukemia by deregulated Rap1 signaling." 京都大学 (Kyoto University), 2008. http://hdl.handle.net/2433/137035.

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8

Macintyre, Andrew Neil. "Phosphoinositide dependent kinase 1 maintains T-Cell metabolism during proliferactive stress." Thesis, University of Dundee, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.510626.

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9

Hertweck, Arnulf. "Dicer-dependent regulation of gene expression and development in T lymphocytes." Thesis, Imperial College London, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.501208.

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10

Martin, Matthew David. "Time-dependent alterations in memory CD8 T cell function after infection." Diss., University of Iowa, 2016. https://ir.uiowa.edu/etd/3138.

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CD8 T cells play a critical role in the clearance of pathogenic bacteria, viruses, and protozoan parasites. Upon encountering their cognate antigen through either infection or vaccination, naïve CD8 T cells undergo robust proliferative expansion, which is followed by contraction and the formation of a memory population. Memory CD8 T cells are long-lived, and because they persist in increased numbers and possess enhanced functional abilities compared to naïve CD8 T cells, they are able to provide the host with increased protection following re-infection. Because of these properties, vaccines de

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11

Doll, Kanne Katherine Lee. "CD8 T cell dependent and independent immunity against Plasmodium following vaccination." Diss., University of Iowa, 2016. https://ir.uiowa.edu/etd/3073.

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Infection with Plasmodium species leads to nearly 400,000 deaths a year despite widespread use of mosquito bed nets, insecticides, and anti-malarial drugs. To date, there is not a licensed vaccine capable of providing complete protection from Plasmodium infection to vaccinees. Whole parasite vaccination of humans and rodents can achieve complete protection in vaccines, but the dose of sporozoites, number of administrations, and production concerns in generating these types of vaccines will likely prevent these approaches from achieving worldwide use. However, the protective immunological respo

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12

Loh, Yik Wen. "Analysis of CD4 T cell-dependent skin and islet graft rejection." Thesis, The University of Sydney, 2014. http://hdl.handle.net/2123/13085.

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Studies described in this thesis made use of the CD4+ 5C.C7 TCR transgenic model to analyse CD4+ T cell responses in two models of fully MHC-mismatched non-vascularised grafting: skin and islet grafts. The crossreactive specificities of the 5C.C7 TCR model allow the investigation of direct allorecognition and the role of heterologously primed memory cells in allogeneic graft rejection or acceptance. Data presented is consistent with a model in which memory, not naïve CD4+ T cells, primed by environmental exposure before the time of grafting and expressing allo-crossreactive specificities, are

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13

Wang, Xiaoting Z. "Organ-Dependent and Epitope-Dependent Repertoire Usage and Apoptosis of Antigen-Specific T Cells in Viral Infections: a Dissertation." eScholarship@UMMS, 2004. http://escholarship.umassmed.edu/gsbs_diss/285.

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During virus infections, activation of CD8 T cells takes place in secondary lymphoid organs including spleen and lymph nodes. The kinetics of the T cell response in lymphoid tissues has been clearly studied. However, a large number of virus-specific T cells disseminate into various nonlymphoid tissues. As reservoirs for effector and memory cells, nonlymphoid organs play an important role for defending against infections. T cell responses in nonlymphoid organs may differ from lymphoid organs. T cell repertoire usage in lymphoid and nonlymphoid tissues was studied in an acute lymphocytic choriom

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14

Ouyang, Li. "The Blimp-1-Dependent Interleukin-2 Inhibitory Loop in CD4+ T cells." Scholarly Repository, 2008. http://scholarlyrepository.miami.edu/oa_theses/98.

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IL-2 has multiple functions in T cell-mediated adaptive immunity. The stringent control of its expression is important for T cell activation, proliferation and the subsequent T cell clone contraction. Our lab has recently shown that the transcriptional repressor Blimp-1 is part of a negative feedback loop which controls IL-2 gene expression in mice. Understanding the molecular mechanisms of this signaling loop in T cells might help us to better understand the regulation as well as the role of IL-2 in T cell immunity. The human ortholog to murine Blimp-1 is termed PRDI-BF1 (each encoded b

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15

Zheng, Lei. "eIF4E-dependent translational control of gene expression in CD4+ T cell subsets." Thesis, McGill University, 2013. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=114555.

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Regulatory T (Treg) cells are important to maintain immune tolerance and homeostasis. Previous genome-wide transcriptional profiles have defined canonical signatures of Treg cells that distinguish them from effector T (Teff) cells. However, compelling evidence shows that changes in total mRNA levels do not always correlate with the protein levels due to post-transcriptional regulation. Our laboratory recently has performed the first genome-wide study on translational control of gene expression in primary CD4+ T cell subsets, and eukaryotic translation initiation factor 4E (eIF4E) is found to b

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16

Vasavda, Nisha. "Steroid dependent asthma : gene expression changes in T-lymphocytes and functional consequences." Thesis, Imperial College London, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.405899.

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17

Ito, Kosei. "c-Jun stimulates origin-dependent DNA unwinding by polyomavirus large T antigen." Kyoto University, 1997. http://hdl.handle.net/2433/202211.

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18

Klemetti, Paula. "T-cell mediated immunity in the pathogenesis of insulin-dependent diabetes mellitus." Helsinki : University of Helsinki, 1999. http://ethesis.helsinki.fi/julkaisut/laa/kliin/vk/klemetti/.

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19

Hoellman, John Richard. "Contact-Dependent Activation of Macrophages by Naive CD4⁺ T cells." [Johnson City, Tenn. : East Tennessee State University], 2000. http://etd-submit.etsu.edu/etd/theses/available/etd-0602100-130806/restricted/electhesisJU21c.pdf.

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20

Tamang, David L. "Modulation of T lymphocyte cytotoxic potential." abstract and full text PDF (free order & download UNR users only), 2008. http://0-gateway.proquest.com.innopac.library.unr.edu/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3307587.

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21

Kapoor, Varun N. "Tissue-dependent T Cell Apoptosis and Transcriptional Regulation of Memory CD8+T Cell Differentiation During Viral Infections: A Dissertation." eScholarship@UMMS, 2013. https://escholarship.umassmed.edu/gsbs_diss/691.

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Activation and proliferation of antigen-specific T cells is the hallmark of an anti-viral immune response. Effector T cells generated during an immune response are heterogeneous in regards to their ability to populate the memory pool once the immune response has resolved. Initial T cell activation takes place in the lymphoid organs, after which T cells migrate into the non-lymphoid tissues. The presence of memory T cells at non-lymphoid tissue sites has been shown to be critical for protection against secondary virus challenge. Our lab has previously demonstrated that during and after the reso

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22

Lam, Eric M. "IDENTIFICATION OF CYCLIN-DEPENDENT KINASE 5 IN T CELLS AND ITS ROLE IN REGULATING T CELL FUNCTION AND DIFFERENTIATION." Case Western Reserve University School of Graduate Studies / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=case1422014852.

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23

Kapoor, Varun N. "Tissue-dependent T Cell Apoptosis and Transcriptional Regulation of Memory CD8+T Cell Differentiation During Viral Infections: A Dissertation." eScholarship@UMMS, 2012. http://escholarship.umassmed.edu/gsbs_diss/691.

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Activation and proliferation of antigen-specific T cells is the hallmark of an anti-viral immune response. Effector T cells generated during an immune response are heterogeneous in regards to their ability to populate the memory pool once the immune response has resolved. Initial T cell activation takes place in the lymphoid organs, after which T cells migrate into the non-lymphoid tissues. The presence of memory T cells at non-lymphoid tissue sites has been shown to be critical for protection against secondary virus challenge. Our lab has previously demonstrated that during and after the reso

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24

Fox, Casey John. "Genetic regulation of contingent macrophage- and T-cell-dependent steps in islet inflammation." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0016/NQ45721.pdf.

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25

Saoulli, Catherine. "CD28-independent, TRAF2-dependent costimulation of resting T cells by 4-1BB ligand." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape11/PQDD_0008/MQ40765.pdf.

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26

Pennavaria, Stefanie [Verfasser], and Reinhard [Akademischer Betreuer] Obst. "mTORC1-dependent RNA synthesis in proliferating T cells / Stefanie Pennavaria ; Betreuer: Reinhard Obst." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2019. http://d-nb.info/1193423236/34.

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27

Sato, Kyosuke. "Physiologic Thymic Involution Underlies Age-Dependent Accumulation of Senescence-Associated CD4+ T cells." Kyoto University, 2018. http://hdl.handle.net/2433/232074.

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28

Cho, Sehyun. "Evaluation of the age-dependent role of natural killer t cells in gammaherpesvirus infection." Thesis, University of British Columbia, 2016. http://hdl.handle.net/2429/56494.

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Epstein-Barr virus (EBV), a human gammaherpesviruses, demonstrates age dependent- pathogenesis. EBV infection in young children is usually asymptomatic, whereas primary EBV infection later in life frequently results in the development of infectious mononucleosis (IM) due to uncontrolled expansion of CD8⁺ T lymphocytes. Natural killer (NK) T cells are innate T lymphocytes that respond to various pathogens through recognition of lipid antigens presented by CD1d receptors. Previous findings suggested that NKT cells have cytotoxic effects on EBV-infected cell lines. Furthermore, infection with ot

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29

Schilke, Angela J. "The parameters of Cyclosporine A induced inhibition of a T cell dependent antibody response." Virtual Press, 1990. http://liblink.bsu.edu/uhtbin/catkey/724567.

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Cyclosporine A (CsA) is a widely used immunosuppressive drug which has novel, clinically beneficial effects on the immune system. Substantial evidence indicates that CsA acts preferentially by impairing T cell lymphokine production, but there is some evidence that CsA may also affect B cells and other antigen presenting cells directly. Using an in vitro antibody response to sheep red blood cells, we have examined the effect CsA has on different populations of mouse lymphocytes. CsA appears to have a direct inhibitory effect on highly purified B cells from naive animals in a dose dependent mann

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30

Turney, Abigail. "Bacterial polysaccharides and their free-radically degraded products in T-cell dependent immunological responses." Thesis, University of Newcastle Upon Tyne, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.394719.

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31

Mori, Masato. "Cell-contact dependent activation of CD4+ T cells by adhesion molecules on synovial fibroblasts." Kyoto University, 2017. http://hdl.handle.net/2433/218010.

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32

El, Sayed Rania. "ROLE OF FDCs AND FDC ACTIVATION IN PROMOTING HUMORAL IMMUNITY INCLUDING RESPONSES TO T-DEPENDENT ANTIGENS IN THE ABSENCE OF T CELLS." VCU Scholars Compass, 2009. http://scholarscompass.vcu.edu/etd/1927.

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Follicular dendritic cells (FDCs) reside in primary B-cell follicles and in the light zones of germinal centers (GCs) in secondary follicles, where their dendrites interdigitate forming extensive networks intimately interacting with B-cells. In GCs, FDCs can be found at the edges attached to the supporting reticular fibers. They trap and arrange immune complexes (ICs) in vivo and in vitro in a periodic manner with 200–500Å spacing and provide both antigen-specific and non-specific accessory signals to B-cells. FDCs exist in resting and activated states, with two characteristically different ph

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33

Lu, Kun-Hui [Verfasser], and Bernd [Akademischer Betreuer] Arnold. "On the Regulation of T Cell‐dependent Immune Responses / Kun-Hui Lu ; Betreuer: Bernd Arnold." Heidelberg : Universitätsbibliothek Heidelberg, 2014. http://d-nb.info/1180032772/34.

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34

Chen, Huaqing. "Covalent chemical events as costimulatory signals in T cell receptor-dependent activation of TH-cells." Thesis, King's College London (University of London), 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.267651.

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35

Huang, W. C. "NKG2D-dependent cross talk between NK cells and CD4 T cells in chronic hepatitis B." Thesis, University College London (University of London), 2016. http://discovery.ucl.ac.uk/1496146/.

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NK cells are emerging as potent regulators of adaptive immunity in virus infection. Our group recently documented the partially TRAIL-dependent deletion of HBV-specific T cells by NK cells. For this study, we investigated the underlying interactions between NK cells and T cells through the NKG2D pathway in chronic HBV infection. In this study, we observed that activated and HBV-specific T cells, especially the CD4 fraction, expressed NKG2D ligands (NKG2D-L) not normally seen on T cells. NKG2D-L upregulation was further enriched on CD4 T cells in HBV-infected livers compared to the circulation

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36

Hornung, Alexander. "Two-dimensional migration of human effector T-cells : integrin-dependent motility studies under shear stress." Thesis, Aix-Marseille, 2016. http://www.theses.fr/2016AIXM4051/document.

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Bien que la description qualitative et phénoménologique de la migration cellulaire soient décrites de façon minutieuse dans son approche holistique, des mécanismes de base et connus depuis longtemps n’ont pas encore été explorés quantitativement avec une approche "bottom-up". Un de ces exemples est le comportement migratoire en deux dimensions des lym- phocytes T effecteurs humains. Alors que leur comportement in vivo est déjà connu depuis longtemps et décrit qualitativement, une approche quantitative in vitro offre de nombreuses perspectives. Les interactions des intégrines LFA-1 et VLA-4 ave

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37

Barron, Luke. "The roles of Bim-dependent apoptosis in controlling the responses of CD4+ T helper lymphocytes." Diss., Search in ProQuest Dissertations & Theses. UC Only, 2007. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3261259.

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38

Phan, Tri Giang. "The SWHEL model for studying B cell responses in tolerance and immunity." University of Sydney. Medicine, 2005. http://hdl.handle.net/2123/626.

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Classical immunoglobulin transgenic (Ig-Tg) mouse models such as the MD4 anti-hen egg lysozyme (-HEL) Ig-Tg line have been used extensively to study B cell responses in tolerance and immunity. This thesis describes a new generation of gene-targeted mice (designated SWHEL mice) whereby the VH10 Ig variable gene encoding the HyHEL-10 specificity of the original anti-HEL Ig-Tg mouse was targeted to the Ig heavy chain locus. B cells in the SWHEL mouse are therefore capable of undergoing class switch recombination (CSR) and somatic hypermutation (SHM), representing a major advance on the original M

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39

Phan, Tri Giang. "The SWHEL model for studying B cell responses in tolerance and immunity." Thesis, The University of Sydney, 2004. http://hdl.handle.net/2123/626.

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Classical immunoglobulin transgenic (Ig-Tg) mouse models such as the MD4 anti-hen egg lysozyme (-HEL) Ig-Tg line have been used extensively to study B cell responses in tolerance and immunity. This thesis describes a new generation of gene-targeted mice (designated SWHEL mice) whereby the VH10 Ig variable gene encoding the HyHEL-10 specificity of the original anti-HEL Ig-Tg mouse was targeted to the Ig heavy chain locus. B cells in the SWHEL mouse are therefore capable of undergoing class switch recombination (CSR) and somatic hypermutation (SHM), representing a major advance on the original M

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40

Sharkey, Craig. "Stress-potentiated memory response to a second Escherichia coli injection is alpha/beta T-cell dependent." Diss., Connect to online resource, 2006. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:1433510.

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41

Hirano, Ayumi. "T dependent B cell help in cattle : immunoregulatory function of interleukin-4 and CD40-CD40L interactions /." free to MU campus, to others for purchase, 1997. http://wwwlib.umi.com/cr/mo/fullcit?p9841150.

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42

Wong, Voon Loong. "Computational studies of shear-dependent non-Newtonian droplet formation at microfluidics T-junction with experimental justification." Thesis, University of Nottingham, 2015. http://eprints.nottingham.ac.uk/28956/.

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When Reynolds number (Re) is typically small, the dominant forces governing droplet formation in a microfluidic system includes surface tension, viscous, adhesion, and inertial forces, and the rheology of fluid becomes significantly important when non-Newtonian fluids are involved. The aim of this thesis is to systematically investigate the non-Newtonian shear-thinning effect of sodium carboxymethylcellulose (CMC) on the physical process of droplet formation. A two-phase conservative level-set formulation is adopted to capture the droplets breakup dynamics and relevant hydrodynamics. Detailed

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43

Gao, Yuanyuan. "Studies on CD40 Signaling-Unpreventable B Cell Receptor-Mediated Apoptosis in T Cell-Dependent Bystander B Cells." 京都大学 (Kyoto University), 2012. http://hdl.handle.net/2433/157848.

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44

Sepako, Enoch. "Influence of HIV and antiretroviral therapy on immunity to pneumococcal T-cell dependent antigens in Malawian adults." Thesis, University of Liverpool, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.569438.

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Background: Natural immunity to S. pneumoniae is thought to rely on antigen-specific T and B memory that can be rapidly mobilised to mediate microbial clearance at the mucosal surface as well as interrupt multiplication following invasion. HIV infection however increases the risk of invasive pneumococcal disease (IPD) and pneumococcal colonisation, suggesting that natural-acquired pneumococcal immunity is compromised in HIV infection. The aim of this research project was to investigate the effect of underlying HIV infection on naturally-acquired pneumococcal immunity in Malawian adults and the

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45

Neideck, Carlos [Verfasser], and Christian [Akademischer Betreuer] Weber. "Ccl17-dependent release of Ccl3 restrains regulatory T cells thereby aggravating atherosclerosis / Carlos Neideck ; Betreuer: Christian Weber." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2018. http://d-nb.info/119221532X/34.

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46

Stubblefield, Park Samantha Renee. "Organotypic brain explants reveal an interleukin-12 / interferon-γ / T-cell dependent clearance of measles virus infection". Case Western Reserve University School of Graduate Studies / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=case1297280439.

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47

Leutwyler, Christoph. "Interleukin-1[Beta] is necessary but not sufficient in anti-CD3-mediated monocyte-dependent T cell proliferation /." [S.l.] : [s.n.], 1994. http://www.ub.unibe.ch/content/bibliotheken_sammlungen/sondersammlungen/dissen_bestellformular/index_ger.html.

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48

Leibfritz, Tobias Sebastian Verfasser], Angelika [Akademischer Betreuer] [Schnieke, and Jens T. [Akademischer Betreuer] Siveke. "JNKs are stress-dependent regulators of acinar maintenance and tumor suppressors in PDAC / Tobias Sebastian Leibfritz. Betreuer: Jens T. Siveke. Gutachter: Jens T. Siveke ; Angelika Schnieke." München : Universitätsbibliothek der TU München, 2015. http://d-nb.info/1079001905/34.

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49

Anderson, Kathleen. "CD25+ CTLA-4+ T Cell-Dependent Induction of Anergic CD25- T Cells Limits the Immune Response to H. pylori Infection Resulting in Mild Gastritis and Persistent Colonization." Connect to text online, 2006. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=case1144332338.

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50

Ng, Yifan. "Cell cycle-dependent and -independent mechanisms of T transcription in the mesodermal differentiation of human embryonic stem cells." Thesis, University of Cambridge, 2015. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.708648.

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