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MINNELLA, MARCO LORENZO. "La responsabilità degli enti per gli infortuni sul lavoro." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2014. http://hdl.handle.net/10281/80475.
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La tesi analizza il fenomeno della responsabilità degli enti per gli infortuni sul lavoro, dal punto di vista criminologico, comparatistico e normativo. Nel primo capitolo si analizza il fenomeno organizzativo nel contesto della "società del rischio" ed i limiti che questa pone alle categorie tradizionali del diritto penale. Si passa poi ad una disamina sulla responsabilità degli enti sul piano strettamente giuridico descrivendo i tre diversi modelli che si sono sviluppati in diversi paesi: modello vicariale (Inghilterra e Francia), modello di transizione (Australia e Stati Uniti), modello autonomo (Svizzera e Inghilterra con la riforma del 2007). Si analizza, infine, l'ordinamento italiano ed in particolare il sistema uscente dall'intreccio delle norme contenute nel D.lgs. 81/2008 (T.U. sulla salute e sicurezza nei luoghi di lavoro) e nel d.lgs. 231/2001 (responsabilità amministrativa degli enti).
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Tu, Tzu-hsin [Verfasser]. "Die Deutsche Ostsiedlung als Ideologie bis zum Ende des Ersten Weltkriegs / Tzu-hsin Tu." Kassel : Kassel University Press, 2009. http://d-nb.info/1011714795/34.
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Jeong, Yu Seon, Minh Vu Luu, Mary Hall Reno, and Ina Sarcevic. "Tau energy loss and ultrahigh energy skimming tau neutrinos." AMER PHYSICAL SOC, 2017. http://hdl.handle.net/10150/625525.
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We consider propagation of high-energy earth-skimming taus produced in interactions of astrophysical tau neutrinos. For astrophysical tau neutrinos, we take generic power-law flux, E-2 and the cosmogenic flux initiated by the protons. We calculate tau energy loss in several approaches, such as dipole models and the phenomenological approach in which parametrization of the F-2 is used. We evaluate the tau neutrino charged-current cross section using the same approaches for consistency. We find that uncertainty in the neutrino cross section and in the tau energy loss partially compensate giving very small theoretical uncertainty in the emerging tau flux for distances ranging from 2 to 100 km and for the energy range between 10(6) and 10(11) GeV, focusing on energies above 10(8) GeV. When we consider uncertainties in the neutrino cross section, inelasticity in neutrino interactions and the tau energy loss, which are not correlated, i.e. they are not all calculated in the same approach, theoretical uncertainty ranges from about 30% and 60% at 10(8) GeV to about factors of 3.3 and 3.8 at 10(11) GeV for the E-2 flux and the cosmogenic flux, respectively, for the distance of 10 km rock. The spread in predictions significantly increases for much larger distances, e.g., similar to 1, 000 km. Most of the uncertainty comes from the treatment of photonuclear interactions of the tau in transit through large distances. We also consider Monte Carlo calculation of the tau propagation and we find that the result for the emerging tau flux is in agreement with the result obtained using analytic approach. Our results are relevant to several experiments that are looking for skimming astrophysical taus, such as the Pierre Auger Observatory, HAWC and Ashra. We evaluate the aperture for the Auger and discuss briefly application to the other two experiments.
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Friedrich, Felix. "Search for neutral Higgs bosons decaying into the leptonic-hadronic di-tau final state in the Minimal Supersymmetric Standard Model with the ATLAS detector." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2017. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-230294.
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A search for the neutral Higgs bosons predicted by the Minimal Supersymmetric Standard Model (MSSM) is presented. The analysis is performed on data from proton-proton collisions at a centre-of-mass energy of sqrt{s}=8 TeV at the Large Hadron Collider recorded by the ATLAS detector. The data were collected in 2012, correspond to an integrated luminosity of 20.3 fb-1 and represent the full 8 TeV dataset. This search is performed in the tau-tau final state, with one tau lepton decaying leptonically and the other hadronically. The analysis is optimized in three categories, addressing low-mass Higgs bosons which are accompanied by a bottom quark induced jet or not and high-mass Higgs bosons. No deviations from Standard Model predictions are observed, and therefore no evidences of new Higgs bosons are found. Exclusion limits are set on the cross-section times branching fraction of the Higgs bosons and for parameters m_A and tan{beta} of MSSM benchmark scenarios<br>In dieser Arbeit wird die Suche nach neutralen Higgs-Bosonen im Rahmen des Minimalen Supersymmetrischen Standardmodells (MSSM) vorgestellt. Die Analyse basiert auf dem kompletten Datensatz von Proton-Proton-Kollisionen des Large Hadron Colliders, LHC, die mit dem ATLAS-Detektor bei einer Schwerpunktsenergie von sqrt{s}=8 TeV im Jahr 2012 aufgenommen wurden. Die Daten entsprechen einer Luminosität 20.3 fb-1. Die Suche fokussiert auf den Tau-Tau Endzustand, wobei ein Tau-Lepton hadronisch zerfällt und das andere leptonisch, entweder in ein Elektron oder in ein Muon. Die Analyse wurde in drei Kategorien optimiert, um sowohl für Higgs-Bosonen im niedrigen Massenbereich von 90-200 GeV als auch im hohen Massenbereich von 200 GeV bis 1 TeV sensitiv zu sein. Der niedrige Massenbereich wurde dabei in zwei Unterkategorien geteilt, entsprechend der Anwesenheit bzw. Abwesenheit von zusätzlichen, durch b-Quarks induzierten Jets, um die Empfindlichkeit für spezielle Higgs-Boson-Produktionsmodi zu erhöhen. Im Rahmen dieser Analyse wurden keine Hinweise auf neue Higgs-Bosonen gefunden und daher Ausschlussgrenzen auf den Wirkungsquerschnitt x Verzweigungsverhältnis gesetzt. Ebenfalls wurden die Resultate in MSSM-Benchmark-Szenarien interpretiert
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Bergström, Lisa. "Tau-patologi och Alzheimers sjukdom – Är tau-immunoterapi en möjlig behandlingsstrategi?" Thesis, Uppsala universitet, Institutionen för farmaceutisk biovetenskap, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-382926.
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Bakgrund: Alzheimers sjukdom (AD) är neurodegenerativ och kännetecknas framför allt av det tidiga symtomet minnesförlust. De patologiska skadorna i hjärnan utmärks av senila plack och neurofibrillära nystan (NFTs). Senila plack består av peptiden amyloid-b (Ab) och NFTs innehåller proteinet tau. Ab har länge stått i fokus när det kommer till patogenesen vid AD och forskning kring behandlingsstrategier mot sjukdomen har länge riktat sig mot denna peptid, men än så länge utan lyckade resultat. Mer fokus har riktats till tau och i nuläget finns det ett antal tau-riktade behandlingsstrategier under utveckling och tau-immunoterapi är en av dessa. Syfte: Idag finns det inte någon behandling som botar AD vilket betyder att det är viktigt att hitta nya behandlingsstrategier mot sjukdomen. Tidigare studier tyder på att tau är ett potentiellt mål för behandling mot AD och syftet med detta arbete var därför att undersöka om tau-immunoterapi är en möjlig behandlingsstrategi vid AD. Metod: Sekundärdata samlades in från databasen PubMed. Datan granskades och bedömdes som användbar eller inte. Detta resulterade i att sju orginalartiklar valdes till arbetet, sex studier i djurmodeller och en klinisk studie. Resultat: Studierna i djurmodellerna visade att tau-immunoterapi reducerade patologiskt tau och i hälften av studierna observerades även en förbättring av de kliniska symtomen. Den kliniska studien visade att AADvac1 är säkert och ansågs vara en lovande kandidat för vidare studier. Slutsats: Resultaten från studierna visar att tau-immunoterapi är en lovande behandlingsstrategi vid AD. Trots detta krävs det fler kliniska studier som undersöker tau-immunoterapi för att säkerställa om behandlingen har någon klinisk effekt på patienter med AD eller inte.
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Valerá-Kounáva, Rodánthi. "Aléxandros Mōraïtídīs (1850-1929) : symvolī́ stī melétī tou diīgīmatografikoú tou érgou /." Athī́na : Ekd.-vivliopōleío Vivliogoniá, 1996. http://catalogue.bnf.fr/ark:/12148/cb370541207.
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Didaktorikī́ diatr.--Tmī́ma filologías tīs Filosofikī́s scholī́s--Panepistī́mio Athīnṓn, 1993.<br>Bibliogr. p. 315-327. Index. Notice translittérée du grec (monotonique) selon la norme ISO 843 (1997).
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Karras, Stephanie. "Modulation der Tau-Aggregation durch Modifikation der Cystein-Reste im Tau-Protein." Doctoral thesis, Universitätsbibliothek Leipzig, 2017. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-219737.
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Tauopathien sind Krankheiten, die mit einer abnormen intrazellulären Tau-Protein-Faltung, Tau-Protein-Aggregation und Filament-Bildung im ZNS und PNS einhergehen. Die Alzheimer Demenz stellt die häufigste Tauopathie dar. Bei ihr kommt es zu einer intra- und extrazellulären Ablagerung fehlgefalteter amyloidogener Proteinaggregate, welche durch β Amyloid und Tau gebildet werden. Es resultiert eine Neurodegeneration.
Ein multifaktorieller Prozess führt bei den Tauopathien zur Umwandlung des Tau-Proteins hin zu unlöslichen Fibrillenbündeln. Primär kommt es zur Bildung eines Dimers, das durch Disulfid- und Wasserstoffbrückenbindungen stabilisiert wird. Durch die Zusammenlagerung mehrer Dimere entstehen Tau-Oligomere. Diese gelten als die neurotoxischen Komponenten.
Die Primärstruktur des Tau-Proteins beeinflusst den Aggregationsprozess. Dabei spielen die Anwesenheit der Aggregationsdomänen PHF6* und PHF6 und die Anzahl der Cystein-Seitenketten überragende Rollen. In dieser Arbeit wurden durch ortsspezifische Mutagenesen Tau-Konstrukte generiert, die sich in ihrer Anzahl der Aggregationsdomänen und der Cystein-Reste unterschieden. Es konnte gezeigt werden, dass die Aggregationstendenz der Tau-Proteine mit nur einer Aggregationsdomäne und keinem Sulfhydryl-Rest stark sinkt.
Auch durch Veränderungen des Redoxmilieus lässt sich das Tau-Aggregationsverhalten beeinflussen. Es wurde gezeigt, dass die Substanz TCEP als starkes Reduktionsmittel die Aggregation der 2 humanen Tau-Isoformen 2N3R und 2N4R wirkungsvoll inhibiert. Auch GSSG als Oxidationsmittel verhinderte in bestimmten Konzentrationen die Aggregation dieser 2 Isoformen. Es wird angenommen, dass die Verhinderung der Bildung einer intermolekularen Disulfidbrückenbindung zu diesem Phänomen führt.
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Rahmat, Rahmat. "Hadronic spectrum of [tau lepton to antipion-neutral pion-tau neutrino] decays /." Connect to title online (ProQuest), 2008. http://proquest.umi.com/pqdweb?did=1617382331&sid=4&Fmt=2&clientId=11238&RQT=309&VName=PQD.
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Thesis (Ph. D.)--University of Oregon, 2008.<br>Typescript. Includes vita and abstract. Includes bibliographical references (leaves 144-149). Also available online in ProQuest, free to University of Oregon users.
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Rahmat, Rahmat 1974. "Hadronic spectrum of tau lepton to antipion-neutral pion-tau neutrino decays." Thesis, University of Oregon, 2008. http://hdl.handle.net/1794/8569.
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xix, 149 p. ; ill. (some col.) A print copy of this title is available through the UO Libraries. Search the library catalog for the location and call number.<br>We report on a study of the invariant mass spectrum of the hadronic system in à - [arrow right] à - à 0 à à à à à ½ à decays. This study was performed using data obtained with the BABAR detector operating at the PEP-II e + e - collider. We present fits to phenomenological models in which resonance parameters associated with the à (770), à '(1450) and à "(1700) mesons are determined. We also discuss the implications of our data with regard to estimates of the hadronic contribution to the muon anomalous magnetic moment.<br>Adviser: Eric Torrence
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Florescu, Alina Anca. "Reduced [tau]_n-factorizations in Z and [tau]_n-factorizations in N." Diss., University of Iowa, 2013. https://ir.uiowa.edu/etd/4844.
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In this dissertation we expand on the study of Τn-factorizations or generalized integer factorizations introduced by D.D. Anderson and A. Frazier and examined by S. Hamon. Fixing a non-negative integer n, a Τn-factorization of a nonzero nonunit integer a is a factorization of the form a = Λ.a1.a2...at where t ≥ 1, Λ= 1 or -1 and the nonunit nonzero integers a1,a2,...,at satisfy a1 ≡ a2 ≡ ... ≡ at mod n. The Τn-factorizations of the form a = a1,a2,...,at (that is, without a leading -1) are called reduced Τn-factorizations. While similarities exist between the Τn-factorizations and the reduced Τn-factorizations, the study of one type of factorization does not elucidate the other. This work serves to compare the Τn-factorizations of the integers with the reduced Τn-factorizations in Z and the Τn-factorizations in N.
One of the main goals is to explore how the Fundamental Theorem of Arithmetic extends to these generalized factorizations. Results regarding the Τn-factorizations in Z have been discussed by S. Hamon. Using different methods based on group theory we explore similar results about the reduced Τn-factorizations in Z and the Τn-factorizations in N. In other words, we identify the few values of n for which every integer can be expressed as a product of the irreducible elements related to these factorizations and indicate when one can do so uniquely.
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Evangelakou, Despoina [Verfasser], Arnulf [Akademischer Betreuer] Quadt, and Ariane [Akademischer Betreuer] Frey. "Z → tau h tau Cross Section Measurement and tau tau Mass Reconstruction with the ATLAS Detector at the LHC / Despoina Evangelakou. Gutachter: Arnulf Quadt ; Ariane Frey. Betreuer: Arnulf Quadt." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2012. http://d-nb.info/1043610294/34.
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Perito, Carl C. "T.S. Eliot and music." Thesis, Hong Kong : Unviersity of Hong Kong, 2003. http://sunzi.lib.hku.hk/hkuto/record/B31953803.
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Romer, S. C. M. "T.S. Eliot : post-symbolist." Thesis, University of Cambridge, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.355282.
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Bartlett, Jami Lyn. "The Victorian T.S. Eliot." Honors in the Major Thesis, University of Central Florida, 1998. http://digital.library.ucf.edu/cdm/ref/collection/ETH/id/22.
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This item is only available in print in the UCF Libraries. If this is your Honors Thesis, you can help us make it available online for use by researchers around the world by following the instructions on the distribution consent form at http://library.ucf.edu/Systems/DigitalInitiatives/DigitalCollections/InternetDistributionConsentAgreementForm.pdf You may also contact the project coordinator, Kerri Bottorff, at kerri.bottorff@ucf.edu for more information.<br>Bachelors<br>Arts and Sciences<br>English; Literature
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Martins, Filipa de Sá. "Abeta dependent tau phosphorylation." Master's thesis, Universidade de Aveiro, 2011. http://hdl.handle.net/10773/7647.
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Mestrado em Biomedicina Molecular<br>Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by the presence of two histopathological hallmarks: the extracellular amyloid plaques (APs) composed of beta-amyloid protein (Abeta) and intracellular neurofibrillary tangles (NFTs), containing hyperphosphorylated tau protein. Therefore, Abeta and tau are important molecules associated with AD and evidence suggests that Abeta may initiate the hyperphosphorylation of tau, which by disrupting neuronal network leads to the process of neurodegeneration. In the present study, using rat primary cortical and hippocampal neuronal cultures, it was shown that exposure to aggregated Abeta1-42 for prolonged periods decreased tau phosphorylation at Ser202 and Thr205 residue, but in contrast increased at Ser262 residue. Tau hyperphosphorylation in AD may be related to alterations in signal transduction pathways involving tau phosphorylation, such as an imbalance in the regulation of protein kinases (PKs) and protein phosphatases (PPs). Thus it is also important to determine which specific PKs and PPs are involved in this process. We observed the involvement of PP1 in the dephosphorylation of tau at Ser202 and Thr205, and the involvement of PP1 and PP2A at the Ser262 residue.
An important aspect of tau metabolism are its binding proteins, and to date many such proteins have already been described both in vitro and in vivo. The interactome of tau is shaped by its phosphorylation and so is crucial to map the crosstalk between normal and pathologically hyperphosphorylated tau. By co-immunoprecipitation we intend to identify proteins that interact with tau and more specifically with phosphorylated tau (p-Tau). Furthermore the effect of Abeta on this interactome should be forthcoming, which is relevant for AD tau pathology.<br>A doença de Alzheimer (DA) é uma doença neurodegenerativa caracterizada pela presença de duas características histopatológicas: as placas senis na matriz extracelular compostas por Beta-amilóide (Abeta) e as tranças neurofibrilhares intracelulares contendo proteína tau hiperfosforilada. Assim, o Abeta e a proteína tau são importantes moléculas associadas à DA e evidências sugerem que o Abeta possa mediar a hiperfosforilação da tau levando á disrupção da rede neuronal e consequentemente ao processo de neurodegeneração. No presente estudo, em culturas primárias neuronais de córtex e hipocampo de rato, verificou-se que a exposição a Abeta1-42 agregado por longos períodos diminui a fosforilação da tau nos resíduos Ser202 e Thr205 e, em contraste, aumenta a fosforilação no resíduo Ser262.
Pensa-se que a hiperfosforilação da tau na DA pode estar relacionada com alterações nas vias de sinalização celular envolvidas no processo de fosforilação da tau, tais como alterações na regulação das cinases e das fosfatases. Deste modo, é também de extrema importância determinar as cinases e fosfatases envolvidas neste processo. Por tratamento de neurónios corticais com diferentes concentrações de ácido ocadéico (AO), um inibidor das fosfatases, verificamos o envolvimento da PP1 na desfosforilação da tau nos resíduos Ser202 e Thr205, bem como o envolvimento da PP1 e PP2A na desfosforilação do resíduo Ser262.
Um outro aspecto importante do metabolismo da tau são as proteínas de ligação, e actualmente já foram descritas várias proteínas que interagem com a tau in vitro e in vivo. O interactoma da tau é regulado pela sua fosforilação e portanto é crucial estabelecer uma relação entre a tau normal e a tau patológica hiperfosforilada no que diz respeito às proteínas de ligação. Por co-imunoprecipitação de neurónios corticais pretendemos identificar proteínas de ligação à tau e especificamente à tau fosforilada, e ainda avaliar o efeito do Abeta neste interactoma. O interactoma da tau dependente da fosforilação e do Abeta é de particular relevância para a compreensão da DA.
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Kraus, Jana [Verfasser]. "W -> tau nu(tau) Cross Section Measurement and Search for the Standard Model Higgs Boson in the tau(lep) tau(had) Final State with the ATLAS Detector / Jana Kraus." Bonn : Universitäts- und Landesbibliothek Bonn, 2015. http://d-nb.info/1077289677/34.
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Dickson, John Robert. "The Role of the Human Tau 3'-Untranslated Region in Regulating Tau Expression." Thesis, Harvard University, 2013. http://dissertations.umi.com/gsas.harvard:11070.
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The microtubule-associated protein tau forms pathological neuronal filaments in Alzheimer's disease (AD) and other neurodegenerative disorders, known collectively as tauopathies. Previous studies in transgenic mouse models of AD suggest that reducing tau expression may be safe and beneficial for the prevention or treatment of AD and possibly other tauopathies. As a first step toward identifying novel therapeutic strategies to reduce tau levels, the studies presented in this dissertation aim to investigate the role of the human tau 3'-untranslated region (3'-UTR) in regulating tau expression. Tau expresses two 3'-UTR isoforms, long and short, as a result of alternative polyadenylation. The exact sequence of these two 3'-UTR isoforms was determined by rapid amplification of cDNA 3'-ends (3'-RACE), and the two 3'-UTR isoforms were cloned into a luciferase reporter vector. Using these reporter constructs, the expression of these isoforms was found to be differentially controlled in human neuroblastoma cell lines M17D and SH-SY5Y by luciferase assays and quantitative PCR (qPCR). Through an unbiased screen of tau 3'-UTR deletions and fragments using luciferase reporter constructs, several regions in the long tau 3'-UTR isoform that contain regulatory cis-elements were identified. Additionally, several microRNAs were computationally identified as candidates that might bind the long tau 3'-UTR and thereby differentially control the expression of long versus short tau 3'-UTR isoforms. Screening these candidate microRNAs via luciferase reporter assay identified miR-34a, which was subsequently shown to repress the expression of endogenous tau protein and mRNA in M17D cells using Western blot and qPCR, respectively. Conversely, inhibition of endogenously expressed miR-34 family members leads to increased endogenous tau expression. Taken together, these studies suggest that the expression of the two tau 3'-UTR isoforms is differentially regulated and that this differential regulation is due to the presence of regulatory cis-elements found only in the long tau 3'-UTR isoform, including a binding site for miR-34 family members. Improved understanding of the regulation of tau expression by its 3'-UTR may ultimately lead to the development of novel therapeutic strategies for the treatment of Alzheimer's disease and other tauopathies.
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Lane, Rebecca. "Searches for neutral Higgs bosons in the tau tau final state at CMS." Thesis, Imperial College London, 2015. http://hdl.handle.net/10044/1/25277.
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The Compact Muon Solenoid (CMS) detector is located at the CERN Large Hadron Collider. It is a general purpose detector designed to test predictions of the standard model (SM) and search for the Higgs boson, as well as to look for signatures of new physics beyond the SM. The analyses described in this thesis use proton-proton collision data recorded by CMS during 2011 and 2012. Searches for neutral Higgs bosons decaying into tau pairs are presented. The searches are performed separately for the SM Higgs boson or the neutral Higgs bosons of the minimal supersymmetric standard model (MSSM). The MSSM searches consist of two different analyses. The first is a direct search for any one of the MSSM neutral Higgs bosons in the mass range from 90 GeV to 1 TeV decaying directly into taus. The second searches for the signature from a heavy neutral Higgs boson of the MSSM decaying into two light MSSM Higgs bosons with SM-like properties (H → hh) in the final state with two b-quarks and two taus. The SM and MSSM ττ analyses use 4.9 fb−1 of data collected at 7 TeV and 19.7 fb−1 collected at 8 TeV, while the MSSM H → hh analysis uses only the 8 TeV data. In the SM analysis, an excess of events in data above the background expectation is observed with an observed (expected) local significance of 3.2 (3.7) standard deviations at 125 GeV. This excess is found to be consistent with the 125GeV Higgs boson of the SM in mass and coupling strengths. No significant excess is observed in either MSSM search, and so upper limits are set on cross-section times branching ratio for the Higgs production processes at the 95% confidence level. Limits are also set in mA-tanβ parameter space of several interesting MSSM benchmark scenarios.
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Foote, Ryan Howard. "A systematic resolution study of [tau][tau] decays at CMS at the LHC." Thesis, Massachusetts Institute of Technology, 2011. http://hdl.handle.net/1721.1/65528.
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Thesis (S.B.)--Massachusetts Institute of Technology, Dept. of Physics, 2011.<br>In title on title page, "[tau][tau]" appear as lower case Greek letters. Cataloged from PDF version of thesis.<br>Includes bibliographical references (p. 47).<br>In this thesis, I perform a systematic resolution study for di-tau pairs at the Compact Muon Solenoid (CMS) experiment at the Large Hadron Collider (LHC) at CERN. I performed this analysis using Monte Carlo simulated events with a Higgs boson which decays into two tau particles with initial mass mH = 90 - 500 GeV/c ² . The two daughter taus were required to then decay leptonically. I determined the dependence of the input mass on the mass resolution and total energy contribution of the electron/muon visible mass peak. For mH 120 GeV/c², a mass resolution of =/< 25% and total energy fraction of =/> 50% can be achieved.<br>by Ryan Howard Foote.<br>S.B.
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Schaller, Marie-Catherine. "Testung einer aktiven Tau-Immunisierung zur Verminderung der Motoneuronendegeneration im Tau-transgenen Mausmodell." Doctoral thesis, Universitätsbibliothek Leipzig, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-183096.
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Immunotherapy for Alzheimer\'s disease has emerged as a promising approach for clearing pathological tau protein conformers. To explore this kind of treatment we tested an active immunization with pseudo-phosphorylated tau fragments in P301L tangle model mice that develop neuronal tau aggregates as observed in frontotemporal dementia and Alzheimer’s disease.
We found that an immunization reduces neurodegeneration in α-motor neurons in the spinal cord and slows progression of the tangle-related behavioral phenotype. Performance on behavioral assays correlated with tau pathology at the corresponding spinal cord level. Interestingly, a slowed progression of these tauopathy related characteristics were only seen in mice that received a specific immunization with pseudo-phosphorylated tau fragments, not in animals that received a non-specific activation of the immune system.
An immunization witch pseudo-phosphorylated tau fragments may be a valuable therapeutic option in targeting one of the major hallmarks of Alzheimer’s disease and frontotemporal dementia.
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Ding, Huiping. "Regulation of tau functions by posttranslational modifications of tau and histone deacetylase 6." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2008. https://www.mhsl.uab.edu/dt/2009r/ding.pdf.
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Williams, Michael D. Jr. "Searching for Clean Observables in $B -> D* /tau- \bar{\nu}_{\tau}$ Decays." VCU Scholars Compass, 2019. https://scholarscompass.vcu.edu/etd/5885.
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In this thesis, the clean angular observables in the $\bar{B} \to D^{*+} \ell^- \bar{\nu}_{\ell}$ angular distribution is studied. Similar angular observables are widely studied in $B \to K^* \mu^+ \mu^-$ decays. We believed that these angular observables may have different sensitivities to different new physics structures.
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Potter, Christopher Thomas. "A search for the rare decay B⁰ (arrow tau⁺ tau⁻) at the Babar experiment /." view abstract or download file of text, 2005. http://wwwlib.umi.com/cr/uoregon/fullcit?p3181121.
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Thesis (Ph. D.)--University of Oregon, 2005.<br>Typescript. Includes vita and abstract. Includes bibliographical references (leaves 219-223). Also available for download via the World Wide Web; free to University of Oregon users.
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Nunes, Hanninger Guilherme [Verfasser]. "Observation of W tau-nu tau decays with the ATLAS experiment / Guilherme Nunes Hanninger." Bonn : Universitäts- und Landesbibliothek Bonn, 2011. http://d-nb.info/101621717X/34.
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Lawhorn, Jay Mathew. "Higgs pair production in [beta][beta][tau][tau] final states at the HL-LHC." Thesis, Massachusetts Institute of Technology, 2015. http://hdl.handle.net/1721.1/100335.
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Thesis: S.B., Massachusetts Institute of Technology, Department of Physics, 2015.<br>In title on title-page, " [beta][beta][tau][tau]" appear as the lower-case Greek letters. Cataloged from PDF version of thesis.<br>Includes bibliographical references (pages 63-66).<br>A measurement of standard model Higgs pair production in [beta][beta][tau][tau] final states at the High Luminosity LHC is investigated. Higgs pair production can be used to measure the Higgs trilinear coupling constant, which uniquely determines the shape of the Higgs potential. The doubly hadronic, hadron-muon, and hadron-electron di-[tau] final states are considered, with a shape analysis on either the stransverse mass (doubly hadronic) or a BDT discriminant (hadron-muon, hadron-electron) distribution performed to extract expected significances. The expected 95% CL upper limit on the cross section times branching ratio from a combination of all three channels is 2.2 times the SM value, with an expected +1[sigma] uncertainty on the measured cross section of 67%, indicating this measurement is feasible.<br>by Jay Mathew Lawhorn.<br>S.B.
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Boillot, Florence. "Polarisation des taus dans la reaction e**(+)e**(-) -> tau **(+)tau **(-) au z : :(o)." Paris 6, 1987. http://www.theses.fr/1987PA066272.
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Reimann, Oliver [Verfasser]. "Tag-free semisynthetic tau proteins and novel antibodies targeted against phospho-tau / Oliver Reimann." Berlin : Freie Universität Berlin, 2017. http://d-nb.info/1136608702/34.
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Wendt, Tina [Verfasser]. "Quantifizierung von Tau, Phospho- Tau und ß-Amyoidfragmenten zur Diagnostik von Demenzerkrankungen / Tina Wendt." Lübeck : Zentrale Hochschulbibliothek Lübeck, 2018. http://d-nb.info/1152030744/34.
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Kostov, I. K., I. Krichever, M. Mineev--Weinstein, P. B. Wiegmann, A. Zabrodin, and Andreas Cap@esi ac at. "$\tau$-Function for Analytic Curves." ESI preprints, 2000. ftp://ftp.esi.ac.at/pub/Preprints/esi888.ps.
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Helbig, Ute. "Beim Lesen tau ich auf." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2010. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-63358.
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In den Sommerferien 2010 wurde der Buchsommer Sachsen ins Leben gerufen. In den USA gibt es bereits erfolgreiche „Summer Reading clubs“und auch in Deutschland gibt es in anderen Bundesländern bereits gute Erfahrungen.
Durch eine einmalige Förderung aus dem Erlös eines Benefizkonzertes des Bundespräsidenten und Mittel des Deutschen Bibliotheksverbands e.V. konnte das Projekt „Beim Lesen tau ich auf“ in den Bibliotheken Leipzig, Chemnitz, Pirna, Döbeln, Schkeuditz, Torgau und Lößnitz erfolgreich erprobt werden.
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Tan, Heng-Ru May. "Neural representation of movement tau." Thesis, University of Edinburgh, 2008. http://hdl.handle.net/1842/2675.
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A fundamental aspect of goal‐directed behaviour concerns the closure of motion‐gaps in a timely fashion. An influential theory about how this can be achieved is provided by the tautheory (Lee, 1998). Tau is defined as the ratio of the current distance‐to‐goal gap over the current instantaneous speed towards the goal. In this work we investigated the neural representation of tau in two sets of experiments. In one study we recorded neuromagnetic fluxes (using magnetoencephalography, MEG) from the whole brain of human subjects performing discrete hand movements aimed to targets in space, whereas the other study involved recordings of single cell activity from prefrontal and posterior parietal areas of a behaving monkey during geometrical shape‐copying tasks. These two studies provided complementary information, for the former covered the whole brain (at the cost of weak localization), whereas the latter used the finest neural grain (at the expense of limited brain regions). However, the two studies together yielded valuable information concerning the dynamic, time‐varying neural representation of tau, with respect to both integrated synaptic events in neuronal ensembles (recorded by MEG) and neural spike outputs (recorded by microelectrodes). The relations between neural signals and tau were analyzed using a linear regression model where the time‐varying neural signal (magnetic field strength in fT or spike density function) was the dependent variable and the corresponding value of movement tau and speed were the independent variables. In addition, the model included an autoregressive term to account for the expected correlated errors, given the time series nature of the data. The neurophysiological study revealed a statistically significant (p < 0.05) relation of spike density function to tau (in the presence or absence of a significant speed effect) in 17% of cells in the posterior parietal cortex (N = 399) and 8% of cells in the prefrontal cortex (N = 163). These results are in accord with previous findings in an interception task. The MEG study revealed that a mean of 21.98 (± 6.08) % of sensor signals had a statistically significant (p < 0.05) relation to tau across all subjects. These effects were distributed predominantly over the left parietal‐temporo‐occipital sensor space, with additional foci over the frontal sensorimotor regions. Altogether, these findings demonstrate a specific involvement of neurons and neuronal ensembles with the tau variable and pave the way for further studies on predictive tau control.
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Gray, Will. "T.S. Eliot among the Metaphysicals." Thesis, University of St Andrews, 2011. http://hdl.handle.net/10023/3123.
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Eliot's admiration for the poetry of the seventeenth century is well known. However, the several documents that explore the subject (thinly scattered across decades) fail to constitute a full account. Drawing on manuscript and print sources, and tracing particularly Eliot's prose poetics, this thesis redresses the scholarly need for a nuanced account of Eliot's role among the Metaphysical poets. The relationship ran in both directions, most famously in Eliot's championing of the poets and his urging that they find a new readership. His part in the revival of Metaphysical poetry, though, has been greatly exaggerated and the record is here faithfully adjusted. He was not in any way responsible for that revival, though he is its most important product, as is shown by a careful reconstruction of turn-of-the-century transcontinental publishing and reception. Eliot's criticism tells its own, largely unexplored story about the Metaphysicals and their influence on his critical and poetic sensibility. Most scholars, for instance, know that Eliot loved Donne, but few know the origin of that interest, let alone its brief nature or the personal reasons that drove him to appreciate the poet's audacity. Most also know the Modernist dicta of Tradition, objective correlative and the dissociation of sensibility, but not the fact that each owes something to Eliot's thinking about Donne. Engaging with Harvard class notes, under-consulted textbooks and a close study of Eliot's articles from the 1910s, two separate chapters investigate his education and early prose, along with their delicate dance between impersonality and confessional criticism. 1921-1926 marks a crucial stage in Eliot's writing, both for his poetry and his criticism. The Metaphysicals provide the clearest barometer of that change as well as the space where he approached conversion. This thesis is the first to trace the poets throughout Eliot's criticism, one of the first to engage with his Metaphysical-themed Clark Lectures, and the first to move far past Eliot's conversion, interpreting George Herbert as typical of his late mindset. In 1961 Eliot claimed no one had been as influenced by the Metaphysical poets as he had been. What this thesis offers is not only a more nuanced portrait of that influence but also a glimpse into the educational, critical and reading cultures of the early 1900s.
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Alwyn, Kim Elizabeth. "Tau lepton studies at BaBar." Thesis, University of Manchester, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.506628.
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Bahbahani, A. "The invisible wagnerite : T.S. Eliot." Thesis, University of Sussex, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.264554.
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The present thesis is about aspects of Wagnerism in the works of T.S. Eliot, in terms of both influence and affinities. The opening chapter offers a brief historical background to Eliot's familiarity with and relation to Wagner, as well as an account of the principal issues to be discussed in the following chapters. The two artists' volumes of criticism mostly show in theory how they work in practice. One key theme there is the maintenance of the idea of tradition and at the same time that of revolutionizing the arts (poetry, opera and drama). Eliot's interest in music, notably in the use of the Wagnerian leitmotif, is one of the highlights of this study. Then, Eliot's concern for myths: his 'mythical method' is discussed in a separate chapter for comparison with Wagner's way of handling myths in his operas. Other important topics feature drama, the Greeks and Shakespeare, and poetry, especially Dante's, the Romantics' and that of the French Symbolists. Certain themes common in both (like salvation and love) are tackled in more than one chapter because of their relevance throughout, but a selection of motifs is singled out in a separate chapter. The study also investigates Eliot's and Wagner's relation to art and life from religious (Buddhism and Christianity) and philosophical (Schopenhauer and Nietzsche) paints of view. Where relevant, some biographical data shedding light on their arts are touched upon--e.g. their personal (including marital) experiences and their anti-Semitism. The concluding chapter rounds off the subject by mainly offering some possible reasons for Eliot's obscure and neglected Wagnerism.
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Lagergren, Jonas. "Swim Tau : Formgivning av inkapsling." Thesis, Mälardalens högskola, Akademin för innovation, design och teknik, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:mdh:diva-24983.
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Under vårterminen 2011 utfördes detta projekt som ett examensarbete i utbildningen Innovation och produktutdesign, högskoleingenjörsprogrammet. Projektet fokuserade på formgivning och omfattade10 veckors heltidsstudier. Denna rapport är en sammanställning av projektets genomförande. Med denna visas arbetsgången och de verktyg och metoder som använts vid genomförandet. Arbetet baserades på ett uppdrag av Lars Asplund som är professor i datateknik vid Mälardalenshögskola. Asplund hade utvecklat plattformen för produkten Swim Tau, som är tänkt som ett hjälpmedel för motionssimmare. Produkten använder sig av trådlös teknologi för att registrera användares simmade längder och sedan lagra dessa i en databas. Den skulle bestå av en basenhet samtbrickor som registreras av en basenhet monterad vid bassängens kant. Basenheten skulle färdigställas som en prototyp för att testas och utvärderas under hösten 2011. Uppdraget var att ta fram underlag förtillverkning av en inkapsling till denna. Genom användning av produktutvecklingsverktyg har en produktutvecklingprocess genomförts för att ta fram ett koncept för en passande inkapsling för produkten. För att skapa en förståelse för miljönprodukten är tänkt att användas i har besök på olika simanläggningar gjorts. Vid möten och samtalmed den simhallsansvarige för Medley, som bedriver verksamhet i simanläggningar runt om i Sverige,införskaffades ytterligare information. Med utvärderingsmatriser och tester har sedan koncepten utvärderats och ett slutgiltigt koncept tagits fram. Konceptet har sedan bearbetats vidare och anpassats efter den tänkta tillverkningsmetoden. En modell ritades upp i 3d-CAD från vilket ritningsunderlag för tillverkning har tagits fram.
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Davis, Daniel Robert. "Modulation of neuronal tau phosphorylation." Thesis, King's College London (University of London), 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.299450.
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Güldemann, Tom. "Studies in Tuu (Southern Khoisan)." Universität Leipzig, 2005. https://ul.qucosa.de/id/qucosa%3A33604.
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The first article proposes a new name for the Southern Khoisan family, based on the fact that all sufficiently attested languages show some reflex of the noun *tuu 'people'. This is a more suitable alternative to previous terms, because it not only unambiguously identifies the genealogical unit and is in line with established conventions for classificatory nomenclature, but also avoids several drawbacks of other terms, among them the heretofore unproven idea of a genealogical unit Khoisan. The second article gives more substantial and systematic evidence that Tuu alias Southern Khoisan itself is in fact a coherent genealogical entity. It first outlines basic structural features of Tuu languages showing that they constitute a robust and typologically fairly distinct language type. It goes on to show that this is associated with a sufficient amount of sound-meaning correspondences, in both grammar and lexicon, in order to warrant an interpretation in terms of inheritance from a common ancestor language. Both studies are the result of work carried out in the project 'Genetic and typological profile of the Tuu language family (alias Southern Khoisan): cataloguing and linguistic analysis of existing sources'. My sincere thanks to the 'Deutsche Forschungsgemeinschaft' for having sponsored this project with a research grant.
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Stachurska, Juliana. "Astrophysical Tau Neutrinos in IceCube." Doctoral thesis, Humboldt-Universität zu Berlin, 2020. http://dx.doi.org/10.18452/21611.
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Das IceCube Neutrino Observatorium am Südpol hat die Existenz eines diffusen astrophysikalischen Neutrinoflusses nachgewiesen. Die Flavor-Zusammensetzung astrophysikalischer Neutrinos trägt Informationen über Orte kosmischer Teilchenbeschleunigung und Auswirkungen potenzieller neuer Physik auf die Neutrinoausbreitung. Zur seiner Bestimmung ist die Beobachtung von Tau-Neutrinos nötig. Ab einer Energie von ~O(100 TeV) kann deren Wechselwirkung über geladene Ströme eine Doppelkaskaden-Topologie ergeben, bei der die zwei Energiedepositionen am Tau-Entstehungs- und Tau-Zerfallsvertex aufgelöst werden können. Diese wird zusammen mit den bereits bekannten Topologien Einzel-Kaskade und Spur zur Messung der Flavor-Zusammensetzung auf der Erde benutzt. In dieser Arbeit werden im Detektorvolumen von IceCube anfangende Ereignisse mit hohen Energien algorithmisch in drei Topologien klassifiziert. Im Datensatz mit einer Lebensdauer von 7.5 Jahren werden zum ersten Mal zwei Doppelkaskaden identifiziert; diese sind Kandidaten für Tau-Neutrinos. Die Eigenschaften der zwei Tau-Neutrino-Kandidaten werden in einer a-posteriori Analyse im Detail studiert. Die statistische Methode wird durch einen Log-Likelihood-Quotienten-Test mit multi-dimensionalen Wahrscheinlichkeitsdichten verbessert. Eine der Doppelkaskaden ist konsistent mit dem Szenario einer misklassifizierten Einzelkaskade, während für die zweite Doppelkaskade die Wahrscheinlichkeit eines nicht-Tau-Neutrino Szenarios auf nur 3% bestimmt wird. Die gemessene Flavor-Zusammensetzung ist konsistent mit der Annahme von astrophysikalischen Neutrinos sowie mit bisher veröffentlichen Resultaten. Die Messung ergibt einen astrophysikalischen Tau-Neutrino Fluss von dPhi / dE=3.0 (-1.8,+2.2) (E / 100TeV)^(-2.87) 10^(-18) GeV^(-1) cm^(-2) s^(-1) sr^(-1), was dem ersten positiven Ergebnis für die Tau-Normalisierung entspricht. Die Nichtexistenz eines astrophysikalischen Tau-Neutrino Flusses wird mit einer Signifikanz von 2.8 sigma abgelehnt.<br>The IceCube neutrino observatory at the South Pole has confirmed the existence of a diffuse astrophysical neutrino flux. The flavor composition of astrophysical neutrinos carries information on the environments at the sites of cosmic particle acceleration as well as potential imprints of new physics acting during neutrino propagation. To measure the flavor composition the observation of the long-elusive tau neutrinos is required. Starting at an energy of ~O(100 TeV) a tau neutrino charged current interaction can produce a double cascade topology, where the two energy depositions from the tau creation and the tau decay vertices are resolvable. This topology together with the well-established track and single cascade topology is used to measure the flavor composition on Earth. In this work, high-energy events starting in IceCube's detector volume are classified algorithmically into the three topologies. In the dataset with a livetime of 7.5 years, two events are classified as double cascades for the first time, yielding multi-TeV tau-neutrino candidates. The properties of the two tau-neutrino candidates are investigated in an a-posteriori analysis. The statistical method is improved by performing a log-likelihood-ratio test using multi-dimensional probability densities. One of the double cascades is consistent with being a misclassified single cascade, while the second double cascade is found to have a misclassification probability of only 3%. The measured flavor composition nu_e:nu_mu:nu_tau = 0.20:0.39:0.42 is consistent with astrophysical neutrinos and with previously published results. The astrophysical tau-neutrino flux is measured to dPhi / dE=3.0 (-1.8,+2.2) (E / 100TeV)^(-2.87) 10^(-18) GeV^(-1) cm^(-2) s^(-1) sr^(-1) with spectral index gamma=2.87 (-0.20,+0.21), yielding the first non-zero results for the tau normalization. The absence of an astrophysical tau-neutrino flux is disfavored at 2.8 sigma.
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Holtmeier, Matthew. "Sigma Tau Delta Lecture Series." Digital Commons @ East Tennessee State University, 2019. https://dc.etsu.edu/etsu-works/7823.
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Boyer, Amanda Merrill. "Potential Tau Directed Imaging Agents." Wright State University / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=wright1453210267.
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Toda, K. "T.S. Eliot and Renaissance drama." Thesis, University College London (University of London), 2015. http://discovery.ucl.ac.uk/1463322/.
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The crucial importance of non-Shakespearian Renaissance dramatists to T.S. Eliot is evident in both his poetry and his prose. Eliot himself drew attention to this: he credited his own ‘poetic formation’ to the ‘minor Elizabethan dramatists’, and when reviewing his ‘critical output for the last thirty-odd years’ in 1951, he confessed himself ‘surprised to find how constantly I have returned to the drama, whether by examining the work of the contemporaries of Shakespeare, or by reflecting on the possibilities of the future.’ As C.S. Lewis disapprovingly wrote, Eliot’s ‘sympathy with depraved poets (Marlowe, Jonson, Webster) is apparent’. This thesis will trace Eliot’s engagement with these dramatists; it is a topic that has been comparatively neglected despite the central role it played in the evolution of his poetic and critical sensibility. The first section, which is largely biographical, explores Eliot’s background and education for clues to the development of his great interest in Renaissance drama, as well as detailing the ways in which he pursued this interest when he moved to England. The second comprises a detailed study of Eliot’s many essays on Renaissance dramatists. The last section examines his poetry, from the juvenilia to The Waste Land of 1922, when the outward signs of his ‘saturation’ were particularly prominent. In my conclusion I discuss how his engagement with Renaissance drama evolved in his post-1922 poetry and culminated in the composition of his own verse plays. The aim of this thesis is to explore the nature of the ‘profound kinship’ Eliot shared with Renaissance dramatists; their work appealed to him because it combines erudition with emotion, refinement with savagery, levity with the macabre and squalid. This appeal was so strong that it powerfully shaped both his poetic ideals and his vision of modernity.
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Månsson, Anders. "Implementering av TPU : En fallstudie om implementeringen av TPU på ABB Cewe-Control i Nyköping." Thesis, Linköping University, Department of Management and Engineering, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-12448.
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<p>För att svenska företag ska kunna konkurrera med företag som har produktion i lågkostnadsländer måste företagen bedriva en effektivare produktion.Syftet med totalt produktivt underhåll (TPU) är att öka företagets lönsamhet genom att höja produktiviteten. TPU är ett arbetssätt där alla medarbetare ska engageras för att minimera störningar och haverier så att utrustningseffektiviteten kan höjas.</p><p>Syftet med rapporten är att utvärdera implementeringen av TPU på ABB Cewe-Control i Nyköping och ge rekommendationer för den fortsatta implementeringen. Som grund för analys och slutsats har en fallstudie på ett pilotavsnitt genomförts. Fallstudien byggs upp till största delen av kvalitativ data i form av deltagande observationer, enkäter och intervjuer.</p><p>Ledningens engagemang är den mest centrala faktorn i implementeringen av TPU. Produktionsledningen på ABB Cewe-Control måste tydligare visa engagemanget i aktiva handlingar för att en förändring ska kunna ske. Resultatet från fallstudien visar på att både medarbetarnas och produktionsledningens engagemang måste höjas för att verksamheten ska kunna utvecklas. För att det framtida arbetet inte heller ska drabbas av onödiga konflikter eller irritation är det viktigt att tydliggöra ansvar och roller vid implementeringen av TPU.</p><p>Fallstudien har också visat på att utbildningen under implementeringen inte har varit tillräcklig. Ordentlig utbildningen behövs för att TPU-arbetet ska kunna bedrivas på ett effektivt sätt och för att höja motivationen hos medarbetarna. Den förbättringsverksamhet som tidigare har bedrivits inom ramarna för verksamhetsutveckling (VU) är en mycket bra grund för förbättringsarbetet i TPU. Det finns ingen anledning till att inte fortsätta med förbättringsverksamheten enligt VU eftersom det är inarbetat i verksamheten och då VU så tydligt kopplar samman gruppernas arbete med företagets strategiska mål.</p><br><p>If Swedish companies are to compete with companies in low-cost countries they have to achieve a more efficient production. The purpose of Total Productivity Maintenance (TPM) is to increase the company's profitability by increasing the productivity. TPM is a method that involves all employees and aims to prevent failures in order to increase the availability of existing equipment.</p><p>The aim of this paper is to evaluate the implementation process of TPM and give recommendations for the further implementation process. The conclusion and the analysis are based on a case study done at a production department at ABB Cewe-Controls facilities in Nyköping. The case study consists mainly of qualitative data from participation observations, surveys and interviews.</p><p>Commitment of the management is a key factor in the implementation process of TPM. The management of ABB Cewe-Control need to demonstrate their commitment in order for a change to happen. The case study shows that the commitment of both employee and management must be raised if the implementation process is to be successful. To avoid unnecessary conflicts or irritation in the further implementation process it is important to clarify responsibilities and roles in the implementation of TPU.</p><p>The case study has also shown that the training during the implementation process has not been sufficient. Proper training is needed to be able to conduct the implementation process of TPM in an effective manner. Proper training is also needed to raise the motivation of the staff.</p><p>Business Development is ABB’s methodology for the improvement work in the company. Business Development is a well-known concept in the organisation and has a well-defined connection with the company's strategic objectives. Because of this there is no reason why the improvement work and how it has been done should change. Business Development is a good foundation for the implementation of TPM and the improvement work in the future.</p>
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Mellone, Manuela. "Sensory ganglia from human P301S tau transgenic mice : a new system to investigate tau pathology." Thesis, University of Cambridge, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.610478.
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Gallu, Raïssa. "Design de polyuréthanes thermoplastiques (TPU) et étude des morphologies multi-échelles de mélanges bitume / TPU." Thesis, Lyon, 2018. http://www.theses.fr/2018LYSEI087.
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Des polyuréthanes thermoplastiques (TPU) contenant des segments rigides et segments souples d’architecture moléculaire variable sont synthétisés en deux étapes, dont la première fait intervenir un pré-polymère polyuréthane. La microstructure de ces polymères montre qu’une séparation de phases intervient entre segments souples et rigides selon la nature des segments utilisés. Les segments rigides peuvent s’organiser sous deux formes, l’une amorphe et l’autre organisée sous forme d’entités cristallines. La morphologie des TPU dépend de la structure chimique du segment rigide employé. L’incompatibilité entre segments souples et rigides a été mise en évidence à partir de l’analyse des paramètres de solubilité complétée des caractérisations à différentes échelles par des techniques de microscopie (électronique et AFM) et de diffusion des rayons X. Ces polyuréthanes thermoplastiques sont ensuite utilisés pour préparer des mélanges bitume –polymère. Les interactions entre segments du polymère et fractions du bitume sont étudiées en considérant les paramètres de solubilité de chacun d’eux et des mesures de gonflement afin de juger de la miscibilité entre les composés. Des huiles modèles sont employées dans le but de mimer certaines fractions huileuses du bitume, et les segments souples et rigides sont synthétisés séparément afin d’étudier les propriétés de chacune des phases en présence dans le mélange bitume – polymère. La morphologie multi-échelle des mélanges est étudiée en lien avec les propriétés rhéologiques et la structure du polymère utilisé. L’ajout de polymère dans le bitume permet de modifier les propriétés viscoélastiques du bitume au-delà de sa transition vitreuse grâce au gonflement sélectif du polymère par les fractions huileuses. Après avoir mis en évidence et analysé le gonflement sélectif grâce à la prise en considération des paramètres de solubilité et mesuré les tensions interfaciales, nous montrons que la présence d’une phase continue riche en polymère contenant des segments rigides semi-cristallins dans les mélanges conduit à retarder l’écoulement du matériau bitumineux à plus hautes températures. La composition en huile de cette phase riche en polymère dépendra de son affinité avec les fractions du bitume et donc de la structure chimique du polymère. De plus, la teneur du polymère en segments rigides semi-cristallins est aussi un levier permettant d’intervenir sur son affinité avec le bitume et par conséquent sur les propriétés rhéologiques du mélange bitume-polymère<br>Thermoplastic polyurethane (TPU) containing hard and soft segments with variable molecular architecture are synthesized in two steps, the first one including a polyurethane pre-polymer. The microstructure of theses polymers shows phase separation occurring between soft and hard segments according to the nature of the segments. Hard segments can organize under two forms, either amorphous or crystalline. The morphology of TPU depends on the chemical structure of the hard segment involved. Incompatibility between soft and hard segments was highlighted from solubility parameters analysis, complete with characterization at various scales with microscopy (electron and AFM) and X-ray scattering technics. Theses thermoplastic polyurethanes are used to prepare bitumen-polymer blends. Interactions between the polymer segments and bitumen fractions are studied, considering solubility parameters of each of them and swelling measurements in order to study miscibility between the compounds. Model oils are used in the aims of mimicking some oily fractions of bitumen, and soft and hard segments are separately synthesized to study properties of each phases in the bitumen-polymer mixture. Multi-scale morphology of the blends is studied in connection with rheological properties and structure of the used polymer. The addition of polymer in bitumen allows to modify viscoelastic properties of bitumen beyond its glass transition due to the selective swelling of the polymer by the oily fractions. Having highlighted and analyzed the selective swelling by considering solubility parameters and interfacial tension measurements, we show that the presence of a continuous polymer-rich phase containing semi-crystalline hard segments in the blends leads to delay the flow of the bituminous material at highest temperatures. The oil composition of this polymer-rich phase will depend on its affinity with the fractions of bitumen and thus on the chemical structure of the polymer. In addition, semi-crystalline hard segment content of the polymer is also a key parameter allowing to adjust its affinity with bitumen and consequently on rheological properties of the bitumen-polymer mixture
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Ngo, Thu Huong. "An investigation into students' motivation to learn English in higher education in Vietnam." Thesis, Queensland University of Technology, 2015. https://eprints.qut.edu.au/84470/1/Thu%20Huong_Ngo_Thesis.pdf.
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This mixed-methods research explored students' motivation to learn English in an attempt to enhance the quality of teaching and learning English in Vietnamese higher education. An intricate picture of students' motivation was revealed: motivation to learn English to gain pragmatic benefits, to satisfy internal aspirations, and in response to external pressures. Students expressed that feeling connected with significant people (lecturers, peers and parents) enhanced their motivation to learn English. This research has significance at both practical and theoretical levels as it provides important insights into the teaching and learning English in Vietnamese higher education and the literature of second language learning motivation.
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Tseng, Tzu-Jung. "Asthma self-management program for adolescents in Taiwan." Thesis, Queensland University of Technology, 2016. https://eprints.qut.edu.au/94102/1/Tzu-Jung_Tseng_Thesis.pdf.
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This thesis reports on a randomised controlled study conducted in Northern Taiwan. This study examined the effectiveness of a newly developed asthma self-management program based on Bandura's self-efficacy model on levels of adolescents' self-efficacy, outcome expectation, asthma self-management behaviours and symptoms of asthma. Study findings have contributed evidence supporting effective developmentally appropriate, educational support strategies for adolescents who, have demonstrated to improvement in prevention and more effective management of their asthma symptoms.
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Boluda, Casas Susana. "Differential induction and spread of tau pathology in young PS19 tau transgenic mice following intracerebral injections of pathological tau from Alzheimer’s disease or corticobasal degeneration brains." Doctoral thesis, Universitat de Barcelona, 2016. http://hdl.handle.net/10803/399674.
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Filamentous tau pathologies are the hallmark lesions of several neurodegenerative tauopathies including Alzheimer’s disease (AD) and corticobasal degeneration (CBD). These diseases show cell type-specific and topographically distinct tau inclusions. Growing evidence supports templated transmission of tauopathies through functionally interconnected neuroanatomical pathways suggesting that different self-propagating strains of pathological tau could account for the diverse manifestations of neurodegenerative tauopathies.
In the study, the rapid induction of tau pathology and the distinct cell type-specific spread of pathological tau following intracerebral injections of CBD or AD brain extracts enriched in pathological tau in human mutant P301S tau transgenic (Tg) mice (line PS19) is analysed.
At 1 mo post-injection of extracts obtained from brains with CBD pathology (CBD-Tau), tau inclusions developed predominantly in oligodendrocytes of the fimbria and white matter near the injection sites with infrequent intraneuronal tau aggregates. In contrast, injections of enriched tau extracts from brains with AD pathology (AD-Tau) in young PS19 mice induced tau pathology predominantly in neuronal perikarya with little or no oligodendrocyte involvement 1 mo post-injection. With longer post-injection survival intervals of up to 6 mo, CBD-Tau and AD-Tau induced tau pathology spread to different brain regions distant from the injection sites while maintaining the cell type specific pattern noted above.
In conclusion, these experiments provide evidence for the prion-like hypothesis of disease spread and suggest that the tau pathology formed in vivo is dependent on the tau pathology in the preparation indicating that there are post-translational modifications or strains of tau protein that are responsible for the variation between diseases.<br>La enfermedad de Alzheimer (AD) y la degeneración corticobasal (CBD) son enfermedades neurodegenerativas que pertenecen al grupo de las taupatías. Estas enfermedades se caracterizan por presentar agregados de proteína tau intracelulares. Cada una de estas enfermedades se manifiesta con unos síntomas clínicos propios, una determinada distribución de los agregados de tau y una afectación celular específica. Estudios recientes sugieren que la proteína tau se puede transmitir de una célula a otra por trayectos anatómicos determinados, a través de la conexión entre neuronas, de forma similar a lo que occurre con los priones.
En el estudio se describe como tras la inyección de extractos enriquecidos con tau patológica obtenidos de tejido cerebral humano de donantes afectos de AD y CBD en ratones transgénicos que sobreexpresan la proteína tau con la mutación P301S (línea PS19) éstos desarrollan patología tau. Los agregados de tau aparecen rápidamente, a los 30 días posteriores a la inyección. Estos agregados presentan unas características similares a las inclusiones observadas en las enfermedades humanas correspondientes, de forma que los ratones inyectados con extractos protéicos obtenidos de casos afectos de CBD desarrollan patología predominantemente en células gliales mientras que los ratones inyectados con extractos obtenidos de casos afectos de AD desarrollan agregados en las neuronas. Asimismo, se observa un incremento de la patología tau con el aumento del tiempo transcurrido después de la inyección así como la propagación a regiones distantes a la zona de inyección que, en el caso de inyecciones con extractos de AD, se encuentran interconectadas mediante vías neuroanatómicas.
En conclusión, estos experimentos proporcionan evidencia de la hipótesis de la transmisión “prion-like” de la enfermedad y sugieren que la patología tau generada in vivo depende de la patología tau en la preparación indicando que hay modificaciones postraduccionales o cepas de la proteína tau que son responsables de la variabilidad entre las enfermedades.
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NIKOLIC, IRENA. "La mesure de la polarisation du tau dans l'experience aleph en utilisant la direction du tau." Paris 11, 1996. http://www.theses.fr/1996PA112130.
Full textAbstract:
Le travail presente dans cette these a ete effectue au sein de l'experience aleph, situee sur le collisionneur electron-positron lep. Ce travail se situe dans le cadre des mesures de precision ayant pour but de determiner les parametres fondamentaux du modele standard des interactions electrofaibles. La mesure de la polarisation du tau permet de determiner avec precision la valeur de l'angle de melange electrofaible, de contraindre les couplages du boson z au lepton tau et a l'electron et de tester l'universalite electron-tau predite par le modele standard. La direction du tau a ete utilisee pour la premiere fois dans la mesure de la polarisation du tau dans cette analyse. L'utilisation de la direction du tau permet d'augmenter la sensibilite de la mesure de la polarisation dans les canaux de desintegrations hadroniques du tau en rho eten al. L'analyse a porte sur les donnees enregistrees par le detecteur aleph de 1990 a 1994, correspondant a 136000 evenements tau. La polarisation du tau mesuree est -0. 1508 0. 0072, ce qui conduit a une valeur de l'angle de melange electrofaible de 0. 23104 0. 00071
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PANZERI, ELENA. "Mutazioni nel gene tau associate ad instabilità cromosomica: un nuovo ruolo della proteina tau. Studio nell'uomo." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2010. http://hdl.handle.net/10281/17980.
Full textAbstract:
Tau is a microtubule associated protein that promotes assembly and stabilization of cytoskeleton microtubules (MT) required for morphogenesis and axonal transport. It is mostly expressed in neuronal and glial cells but it is also present in non-neuronal cells such as fibroblast, lymphocytes and lymphoblasts where it can play further functions.
Six major tau isoforms are expressed in adult human brain, as a result of alternative mRNA splicing of exons 2, 3 and 10 of MAPT, a gene located on 17q21.1 where it occupies over 100 kb. Tau is subjected to different post-translational modifications, among which phosphorylation is known to negatively regulate its ability to bind to MT. In fact, in cycling cells, tau has a low level of phosphorylation and is mostly bound to MT during interphase, while at the onset of mitosis, it became highly phosphorylated reducing its affinity to MT and permitting their dinamic instability required for the rapid mitotic movements. Abnormal hyperphosphorylation of tau causes disruption of cytoskeleton and deposition of hyperphosphorylated tau filaments in neuron and glial cells, resulting in cerebral atrophy and dementia, hallmarks of Alzheimer’s disease as well as of the so-called tauopathies, adult-onset diseases that can be of genetic origin and caused by dominant mutations in MAPT, among which frontotemporal dementia (FTD) is the most frequent.
Missense, deletion and silent mutations have been reported in the coding region of MAPT, with additional mutations in the intronic region close to the 5’ splice site of exon 10.
Very recently it has been proposed an involvement of tau in chromosome stability, based on its localization both in the interphasic nucleus and along mitotic chromosomes and on the presence of several chromosome and chromatin aberrations in fibroblasts and lymphocytes of patients affected by FTD carrying P301L mutation (Rossi G et al., 2008).
In the present study, in order to establish whether chromosomal aberrations are a general phenomenon in tauopathies rather than a unique feature of the P301L mutation, we investigated these alterations in somatic cells of patients bearing different MAPT mutations with standard (karyotype) and molecular (array-CGH) cytogenetic techniques. Furthermore, since the observed chromosome instability resembled some features of what is seen in syndromes caused by mutations in genes involved in the DNA repair systems, we tested the response of mutated lymphoblastoid cell lines to genotoxic agents, able to induce single- and double-strand breaks.
Lymphocytes and fibroblasts of patients showed a significantly higher level of structural aberrations and total aneuploidy compared to controls. We observed also a high level of premature chromatid division (pcd), that is correlated with chromosome segregation defects and aneuploidies, and abnormal nuclei. Condensations defects were also widely present in the patients and not in the controls, thus a role of tau in condensation or decondensation of chromatin may be hypothesized.
Analyzing lymphoblastoid cell lines treated with genotoxic agents, we have not yet demonstrated an involvement of the protein in DNA repair systems, but these results need to be confirmed.
Our findings indicate that tau may be involved in chromosome segregation and stabilization of chromatin structure most likely through interactions with both microtubules and chromatin itself.
The occurrence of numerical chromosome aberrations in FTD patients is likely due, at least in part, to misfunction of tau as a MT associated protein, since the mutations studied decrease the binding of the protein to MT, producing an instable spindle. Fragility and alterations in chromosome structure due to mutated nuclear tau may slowly accumulate in postmitotic cells and lead to abnormal regulation of gene expression with subsequent neuronal damage and death.
The evidence of a role of tau in the functioning of mitotic spindle and stability of chromatin points to this protein as a possible component of the complex system guarding genome stability.
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Papp, Victoria Nicole Kortes. "Ritual in T.S. Eliot's longer poems." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/mq25695.pdf.
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