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Dissertations / Theses on the topic 'Tablet Dosage Form'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Lam, Matthew. "The making of liqui-pellet and liqui-tablet, the next generation oral dosage form." Thesis, University of Sussex, 2019. http://sro.sussex.ac.uk/id/eprint/81934/.

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2

Bredenberg, Susanne. "New Concepts in Administration of Drugs in Tablet Form : Formulation and Evaluation of a Sublingual Tablet for Rapid Absorption, and Presentation of an Individualised Dose Administration System." Doctoral thesis, Uppsala University, Department of Pharmacy, 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3433.

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<p>This thesis presents two new concepts in oral drug administration and the results of evaluation of some relevant formulation factors.</p><p>Investigation into improving the homogeneity of mixtures for tableting indicated that it may be possible to obtain interactive dry mixtures of micronised drugs containing drug proportions as low as 0.015% w/w. By studying the relationship between disintegration time and tensile strength, it was found that the microstructure surrounding the disintegrant particles may influence the disintegration process. Therefore, avoidance of excipients which are highl

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3

Pavurala, Naresh. "Oral Drug Delivery -- Molecular Design and Transport Modeling." Diss., Virginia Tech, 2013. http://hdl.handle.net/10919/53505.

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One of the major challenges faced by the pharmaceutical industry is to accelerate the product innovation process and reduce the time-to-market for new drug developments. This involves billions of dollars of investment due to the large amount of experimentation and validation processes involved. A computational modeling approach, which could explore the design space rapidly, reduce uncertainty and make better, faster and safer decisions, fits into the overall goal and complements the product development process. Our research focuses on the early preclinical stage of the drug development process

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4

Blair, Tina Caroline. "Some factors influencing the survival of microbial contamination in solid oral dosage forms." Thesis, King's College London (University of London), 1989. https://kclpure.kcl.ac.uk/portal/en/theses/some-factors-influencing-the-survival-of-microbial-contamination-in-solid-oral-dosage-forms(25307998-751d-4cb1-ae1b-49bf680e395c).html.

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5

Patel, Fathima. "The development and assessment of a generic carbamazepine sustained release dosage form." Thesis, Rhodes University, 2006. http://eprints.ru.ac.za/1339/.

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6

Munday, Dale Leslie. "Design, development and evaluation of encapsulated oral controlled release theophylline mini-tablets." Thesis, Rhodes University, 1991. http://hdl.handle.net/10962/d1003255.

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Conventional solid dosage forms often lead to fluctuations which exceed the maximum safe therapeutic level and/or decline below the minimum effective level. It is recognised that many drugs for chronic administration should be administered on a schedule that maintains plasma drug concentration within the therapeutic window. Research in controlled release dosage forms aims at designing a system with a zero-order input (eg, ideally to deliver 8.33% of the dose per hour over a 12 hour duration), producing steady state plasma drug levels. Oral dministration of drugs prepared as a controlled releas

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7

Kieser, Leith Faye. "Formulation and assessment of monolithic beta blocker sustained release tablets prepared by direct compression." Thesis, Rhodes University, 2002. http://hdl.handle.net/10962/d1003242.

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Beta blockers are commonly prescribed for the chronic treatment of hypertension, one of the most prolific disease states worldwide. The beta blockers selected for this study include acebutolol hydrochloride, labetalol hydrochloride, metoprolol tartrate oxprenolol hydrochloride and propranolol hydrochloride. All of these compounds have a short elimination half-life, necessitating multiple dose per day regimens and therefore the development of sustained release dosage forms incorporating these agents was considered beneficial in terms of extending the dosing interval, with the aim of improving p

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8

Kindgen, Sarah M. [Verfasser]. "Hydrodynamics and solid dosage form disintegration/dissolution : immediate release tablets and novel in situ polyelectrolyte gastroretentive drug delivery systems / Sarah M. Kindgen." Mainz : Universitätsbibliothek der Johannes Gutenberg-Universität Mainz, 2015. http://d-nb.info/1225749581/34.

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9

Nobusa, Ana Lucia. "Desenvolvimento e avaliação de minicomprimidos de indapamida de liberação prolongada." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/9/9139/tde-08072011-104933/.

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A hipertensão arterial é a principal causa da incidência de doenças cardiovasculares no mundo. Os diuréticos anti-hipertensivos como a indapamida são muito utilizados para o tratamento da hipertensão arterial, sendo a formulação de liberação prolongada muito eficaz e bem tolerada para o uso em pacientes idosos. Sistemas multiparticulados de formas farmacêuticas sólidas orais de liberação prolongada apresentam uma série de vantagens tecnológicas e biofarmacotécnicas em relação aos sistemas monolíticos.Assim, o presente trabalho teve como objetivo desenvolver formas farmacêutica sólidas multipar

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10

Mourão, Samanta Cardozo. "Correlação in vitro in vivo para formas farmacêuticas sólidas de liberação modificada contendo diclofenaco de sódio." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/9/9139/tde-06052010-095135/.

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A correlação in vitro-in vivo (CIVIV) refere-se ao estabelecimento de uma relação racional entre as propriedades biológicas, ou parâmetros derivados destas, produzidos por uma forma farmacêutica e suas propriedades ou características físico-químicas. O estabelecimento desse tipo de correlação de dados pode possibilitar a substituição dos estudos in vivo, necessários à demonstração da bioequivalência, pelos estudos in vitro, no caso de alterações no processo de fabricação pós-registro. Os sistemas matriciais apresentam, como principal exemplo de material controlador da liberação, substâncias po

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11

Joseph, Ashton Edward. "Comparison of the sutherlandioside B levels in two commercially available Sutherlandia frutescence preparations and the effect of elevated temperature and humidity on these levels." Thesis, University of the Western Cape, 2009. http://etd.uwc.ac.za/index.php?module=etd&action=viewtitle&id=gen8Srv25Nme4_1532_1299237071.

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<p>Sutherlandia frutescens (tribe Galegeae, Fabaceae), is a popular medicinal plant traditionally used in South Africa. In 2000, a company called Phyto Nova (Pty) Ltd. initiated large-scale cultivation and contract manufacturing of tablets, made from the powdered herb (i.e. thin stems and leaves). Most of these commercial Sutherlandia solid dosage forms are made from the dried leaf powder but recently a new product, viz. Promune&trade<br>capsules, made from a freeze-dried aqueous extract, came on the market and was claimed to be &ldquo<br>better&rdquo<br>as it mimics the traditional tea. Howev

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12

Boiret, Mathieu. "Towards chemometric methodologies on hyperspectral imaging for low dose compound detection : application on Raman microscopy." Thesis, Montpellier, 2015. http://www.theses.fr/2015MONTS291.

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L’imagerie hyperspectrale est désormais considérée comme un outil analytique à part entière dans l’industrie pharmaceutique, aussi bien au cours du développement pour assurer la qualité d’un produit que pour résoudre des problématiques de production après la mise sur le marché du médicament. Dans ces travaux, la microscopie Raman est utilisée pour étudier la distribution en principes actifs et excipients au sein d’une forme pharmaceutique solide, en se focalisant tout particulièrement sur l’identification d’un composé faiblement dosé. Ce dernier est défini comme étant un produit ayant de faibl

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13

Ahmat, Norhayati, Hassan Ugail, and Castro Gabriela Gonzalez. "Modelling the Mechanical Behaviour of a Pharmaceutical Tablet Using PDEs." 2012. http://hdl.handle.net/10454/5428.

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yes<br>Detailed design of pharmaceutical tablets is essential nowadays in order to produce robust tablets with tailor-made properties. Compressibility and compactibility are the main compaction properties involved in the design and development of solid dosage forms. The data obtained from measured forces and displacements of the punch are normally analysed using the Heckel model to assess the mechanical behaviour of pharmaceutical powders. In this paper, we present a technique for shape modelling of pharmaceutical tablets based on the PDE method. We extended the formulation of the PDE method t

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14

Yang, Ning-Ning. "Product formulations and in vitro-in vivo evaluation of a novel "Tablet-in-a-Bottle" suspension formulation of amoxicillin and clavulanic acid." Thesis, 1997. http://hdl.handle.net/1957/33676.

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This thesis describes a novel "Tablet-in-a-Bottle" oral suspension formulation. Ingredients with unstable physical or chemical characteristics can be placed in a core tablet, and then dry compression coated with an outer layer which provides separation from other components. The new suspension formulation comprises fast disintegrating clavulanic acid (KCA) tablets with a powder mixture containing amoxicillin. Hardness, friability, flow properties and weight uniformity of tablets for three different formulations were investigated and were all improved in a third formulation. Stability tests und

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15

Cook, Rebecca. "In-vitro testing of the influence of ethanol on the release rate of oral extended-release solid dosage forms." 2007. http://hdl.rutgers.edu/1782.2/rucore10001600001.ETD.13454.

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16

Ahmed, Salah Uddin. "Development of oral sustained release tablet dosage forms for sparingly water soluble and highly water soluble drugs : physicochemical, biopharmaceutical and technological considerations /." 1989. http://www.gbv.de/dms/bs/toc/128347236.pdf.

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17

Robles-Martinez, P., X. Xu, S. J. Trenfield, et al. "3D Printing of a Multi-Layered Polypill Containing Six Drugs Using a Novel Stereolithographic Method." 2019. http://hdl.handle.net/10454/17370.

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Yes<br>Three-dimensional printing (3DP) has demonstrated great potential for multi-material fabrication because of its capability for printing bespoke and spatially separated material conformations. Such a concept could revolutionise the pharmaceutical industry, enabling the production of personalised, multi-layered drug products on demand. Here, we developed a novel stereolithographic (SLA) 3D printing method that, for the first time, can be used to fabricate multi-layer constructs (polypills) with variable drug content and/or shape. Using this technique, six drugs, including paracetamo

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18

Joshi, Anjali. "Development and Evaluation of Fixed Dose Combination Orally Disintegrating Tablets of Antiretroviral Drugs for Pediatrics." 2012. http://digital.library.duq.edu/u?/etd,162264.

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The thesis work entails a bench-to-bedside translational research approach to the development of pediatric fixed dose combination of zidovudine/lamivudine/nevirapine (60/30/50mg) orally disintegrating tablets. A simple and cost-effective, direct compression method was used. Preformulation studies that included analytical and bio-analytical assay development, excipient selection and characterization of drug-excipient interaction for initial formulation were conducted. Response surface methodology was utilized to optimize the formulation in terms of disintegration time and crushing strength. Sta

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19

Kluberg, Sheryl. "Evaluating South African policies for linkage to and retention in HIV care using quasi-experimental methods." Thesis, 2017. https://hdl.handle.net/2144/27163.

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South Africa has the largest HIV-infected population in the world, with 2015 estimates of 7 million people living with HIV and 180,000 AIDS-related deaths. The South African government began scale-up of a public-sector HIV care and treatment program in 2004, and by the end of 2015, 3.4 million HIV-infected individuals were on antiretroviral therapy (ART). When scale-up began in South Africa, ART was only available to HIV-infected individuals with CD4 counts ≤200 cells/µL or WHO clinical stage 4 disease. In 2010, treatment was extended to patients who were pregnant or who had tuberculosis a

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20

Hobbs, Kim Melissa. "Development of a novel rate-modulated fixed dose analgesic combination for the treatment of mild to moderate pain." Thesis, 2010. http://hdl.handle.net/10539/8733.

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MSc (Med),Dept of Pharmacy and Pharmacology, Faculty of Health Sciences, University of the Witwatersrand<br>Pain is the net effect of multidimensional mechanisms that engage most parts of the central nervous system (CNS) and the treatment of pain is one of the key challenges in clinical medicine (Le Bars et al., 2001; Miranda et al., 2008). Polypharmacy is seen as a barrier to analgesic treatment compliance, signifying the necessity for the development of fixed dose combinations (FDCs), which allow the number of tablets administered to be reduced, with no associated loss in efficacy or in

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21

Joseph, Ashton Edward. "Comparison of the sutherlandioside B levels in two commercially available sutherlandia frutescens preparations and the effect of elevated temperature and humidity on these levels." Thesis, 2009. http://hdl.handle.net/11394/3283.

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