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Journal articles on the topic 'Tablet hardness'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Wang, Yifei, Zhisheng Wu, Zhaoyi Wang, Manfei Xu, Xinyuan Shi, and Yanjiang Qiao. "Rapid analysis of spatial distribution of PVPP and hardness of Yinhuang dispersible tablets by NIR-CI." Journal of Innovative Optical Health Sciences 09, no. 02 (2016): 1550016. http://dx.doi.org/10.1142/s1793545815500169.

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The present study aimed at investigating the relationship between tablet hardness and homogeneity of different Yinhuang dispersible tablets by near-infrared chemical imaging (NIR-CI) technology. The regularity of best hardness was founded between tablet hardness and the spatial distribution uniformity of Yinhuang dispersible tablets. The ingredients homogeneity of Yinhuang dispersible tablets could be spatially determined using basic analysis of correlation between analysis (BACRA) method and binary image. Then different hardnesses of Yinhuang dispersible tablets were measured. Finally, the re

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Rosaini, Henni, Rina Wahyuni, Addina Zafrul, and Ela Indah Sari. "FORMULATION AND CHARACTERIZATION OF TABLETS FROM SIMPLICIA AND EXTRACT OF SUNGKAI’S (Peronema canescens Jack) LEAF." International Journal of Pharmaceutical Sciences and Medicine 8, no. 10 (2023): 65–75. http://dx.doi.org/10.47760/ijpsm.2023.v08i10.006.

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Tablets are solid preparations containing medicinal ingredients with or without excipients, usually consisting of one or more active substances. Preparations in tablet form have the best mechanical, chemical, and microbiological stability compared to liquid dosage forms, so they are more resistant to physical damage. This study aims to formulation and characterization of tablet from simplicia and dried extract of sungkai’s (Peronema canescens Jack) leaf by wet granulation which consisted of three formulas, namely F1 without active substances, F2 active substances from sungkai’s leaf simplicia,

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3

Luke, Stefani, Martha Ervina, and Lannie Hadisoewignyo. "Optimization of Coating Formula of White Pomegranate Peel Extract (Punica granatum L.) Film Coated Tablet Using Kollicoat Protect." Indonesian Journal of Pharmaceutical Research 1, no. 1 (2021): 19–27. http://dx.doi.org/10.31869/ijpr.v1i1.1993.

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White pomegranate peel has many kinds uses, one of them as antimalaria. The unpleasant appearance and bitter taste of white pomegranate peel tablet can be covered by film coated using Kollicoat Protect. This research aimed to determine the effect of concentration and type of solvent used as a coating on the physical properties of the coated tablets and determine the optimum formula. Tablets were made using direct compression method and then coated using Kollicoat Protect. The optimization of coating formula was performed using a factorial design with design expert software ver 10.0. Responses

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Sari, Rodiah Nurbaya, Hari Eko Irianto, and Ema Hastarini. "Production of Unsaturated Fatty Acids Concentrate Tablets from Sardinella sp. Oil." E3S Web of Conferences 147 (2020): 03008. http://dx.doi.org/10.1051/e3sconf/202014703008.

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Tablets are medicinal ingredients in solid dosage forms which are usually prepared with suitable pharmaceutical ingredients. In this study, unsaturated fatty acids concentrate from Sardinella sp. oil was used as raw material and then it was microencapsulated. The microcapsule was formulated into a tablet with proportion of 250 mg concentrated unsaturated fatty acids for each 450 mg tablet. Tablet granules were analyzed for compressibility, flow rate, and fixed angle. While, the tablets were determined for weight uniformity, released time, hardness, and tablet size uniformity. The results showe

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Dadang Putra Mardigantara, Mikhania C. E. ,. Dewi rashati,. "PERBANDINGAN SIFAT FISIK TABLET SALUT CIPROFLOXACIN 500 MG MEREK GENERIK DAN MEREK DAGANG." JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER 1, no. 1 (2021): 7–12. http://dx.doi.org/10.53864/jifakfar.v1i1.5.

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The aim of this study was to compare physical properties ciprofloxacin 500 mg coated tablet generic and trademark brand. The test include weight uniformity, tablet hardness, tablet friability, and disintegration time test. Descriptive experimental design (the one-shot case study) was used as study design. Samples were taken from three generic brands and three trademarks brand ciprofloxacin 500 mg coated tablets. Samples were produced by different factories and taken by simple random sampling method. The results showed that ciprofloxacin 500 mg coated tablets generic and trademark brand are com

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6

Chongcherdsak, Noppadol, Chutima Limmatvapirat, and Sontaya Limmatvapirat. "Factors Affecting Design of Shellac-Based Matrix Tablet through Annealing Process." Advanced Materials Research 506 (April 2012): 421–24. http://dx.doi.org/10.4028/www.scientific.net/amr.506.421.

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The aim of research was to elucidate effect of annealing temperature and shellac (SHL) content on properties of shellac-based matrix tablets. Theophylline was selected as a model drug. The tablets were prepared by direct compression process and then annealed at various temperatures for 24 hours. The tablet properties, including hardness and disintegration time were comparatively. The result demonstrated that annealing temperature directly affected the hardness and disintegration time of tablets. At 60oC or more, the hardness was increased more than 1.5 times as compared to that of un-annealed

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7

Kuwata, Aya, Agata Ishikawa, Tetsuo Ono, and Etsuo Yonemochi. "Granulation Methods and the Mechanisms for Improving Hardness of Loxoprofen Sodium Hydrate-Containing Tablets." Pharmaceutics 17, no. 4 (2025): 455. https://doi.org/10.3390/pharmaceutics17040455.

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Objectives: We investigated the compression mechanisms for loxoprofen sodium (LXP), which is known to occur as a dihydrate, and identified parameters that influence the tablet hardness of LXP tablets prepared by the wet granulation method. Method: LXP granules were prepared with water or ethanol as the solvent, dried under various conditions and sieved for particle size control, with 1% Mg-st added before tablet compression. Results: The findings indicated that both the granulation solvent and drying temperature significantly impacted the tablet hardness. Granules prepared with ethanol exhibit

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Sipos, Emese, Andrea Ramona Oltean, Zoltán-István Szabó, Emőke-Margit Rédai, and Gabriella Dónáth Nagy. "Application of SeDeM expert systems in preformulation studies of pediatric ibuprofen ODT tablets." Acta Pharmaceutica 67, no. 2 (2017): 237–46. http://dx.doi.org/10.1515/acph-2017-0017.

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Abstract Pediatric, ibuprofen containing orodispersible tablets (ODTs) were prepared using the SeDeM expert system methodology. In order to facilitate formulation, directly compressible ibuprofen was employed (Ibuprofen DC 8TM) and characterized using its SeDeM profile. The mannitol based superdisintegrant Ludiflash® was characterized by the SeDeM-ODT expert system, which also allowed calculation of the optimal excipient concentration in order to obtain suitable tablet hardness and disintegration time. After adding a sweetener and a standard combination of lubricants, the optimized formulation

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9

Muhammad Rezky Wahyudi, Yumna Zaida, Fiona Maulidia, Regina Nabila, Della Puspita, and Nor Latifah. "Pengaruh Variasi Bahan Pengikat Alami dan Sintetis terhadap Kekerasan dan Kerapuhan Tablet." An-Najat 2, no. 4 (2024): 246–57. https://doi.org/10.59841/an-najat.v2i4.1955.

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Tablets are one of the most widely used pharmaceutical forms due to their practicality and cost-effectiveness. In the tablet formulation process, binders play an important role in ensuring appropriate hardness and friability, which are crucial in maintaining the physical quality of the tablet. This study aims to compare the effectiveness of natural and synthetic binders in enhancing tablet hardness and reducing friability. The method used is a literature review from various scientific sources. The results show that natural binders, such as starch and gelatin, can increase tablet hardness and r

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Sinaga, Alex Handani, and Novicha Aulya Fendri. "Addition Of Various Concentrations Of Gadung Tuber Starch Which Is Determined As A Binder To The Physical Properties Of Mefanamic Acid Tablets By Wet Granulation." Jurnal Kesehatan, Rekam Medis dan Farmasi (JUK-Medifa) 2, no. 01 (2023): 25–31. https://doi.org/10.58471/juk-medifa.v2i01.234.

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n previous studies, the polysaccharide extract of gadung tuber has a hypoglycemic effect, wherein the plant contains a high glycemic index indicating that carbohydrates undergo rapid digestion and are absorbed in large quantities so that blood glucose levels suddenly experience a rapid rise in insulin which can lower cholesterol values. (Sumunar et al., 2015) This research method is an experiment in which this research was carried out, by making starch from gadung starch and making tablets by wet granulation. Based on the results of the research that has been done, it can be concluded that the

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Ghina Faiha, Rina Suspa Nita, Nadia Nadia, Devira Niken Putri Ferdinand, Akhmad Rizky Akbar, and Nor Latifah. "Review Jurnal: Evaluasi Kekerasan Sediaan Tablet Kunyah dengan Metode Kempa Langsung." An-Najat 2, no. 4 (2024): 258–62. https://doi.org/10.59841/an-najat.v2i4.1956.

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Tablets are one of the most widely used forms of preparation on the market, one type of tablet preparation is chewable tablets. Chewable tablets are drugs that are consumed by chewing first before being swallowed. The manufacture of chewable tablets usually uses the direct felt method which is done by directly shaking a mixture of powder (active substances and excipients). The purpose of this article is to analyze various aspects related to the quality, efficiency, and stability of chewable tablets made using the direct felt method, to identify the hardness test parameters. The method used in

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12

Peng, Qiushi, Yi Bao, Tingyu Chen, Qianrong Peng, and Min Yang. "A Rapid and Nondestructive Method for the Prediction of Ibuprofen Tablet Hardness Using NIR Diffuse Reflectance Spectroscopy." Current Pharmaceutical Analysis 15, no. 5 (2019): 439–46. http://dx.doi.org/10.2174/1573412914666180427092727.

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Introduction: This study aimed at developing a technology to measure the hardness of Ibuprofen (IBU) tablets and optimize the IBU formulation using Near-infrared (NIR) spectroscopy. Materials and Methods: Tablets (400 mg±5%, 10mm in diameter) consisting of IBU, microcrystalline cellulose SH-103, carboxymethyl starch sodium, magnesium stearate, silicon dioxide were formed of various hardness (2kg, 4kg, 6kg, 8kg, 10kg, 12kg). The reflectance NIR spectra of various tablets were employed to establish 9 calibrations models, which were further used to predict tablet hardness by Partial least squares

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Mrs. Pritha Singha Roy, Mrs Pritha Singha Roy, Mr Ankush Biswas Mr. Ankush Biswas, Smriti Pratihar Smriti Pratihar, and Arup Kumar Ghosh Arup Kumar Ghosh. "Effect of Different Binders on Tablet Hardness and Disintegration." International Journal of Pharmaceutical Research and Applications 10, no. 2 (2025): 1612–20. https://doi.org/10.35629/4494-100216121620.

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Binders are essential excipients in tablet formulations that influence the mechanical integrity and performance of the dosage form. The present study aimed to evaluate the effects of different binders—namely starch, polyvinylpyrrolidone (PVP K30), gelatin, acacia, and hydroxypropyl methylcellulose (HPMC)—on tablet hardness and disintegration time using a model drug (paracetamol). Five formulations were prepared via wet granulation, maintaining binder concentration at 5% w/w. Standard pre-compression and postcompression parameters were assessed, including flow properties, hardness, friability,

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Monton, Chaowalit, Thaniya Wunnakup, Jirapornchai Suksaeree, Laksana Charoenchai, and Natawat Chankana. "Impact of Compressional Force, Croscarmellose Sodium, and Microcrystalline Cellulose on Black Pepper Extract Tablet Properties Based on Design of Experiments Approach." Scientia Pharmaceutica 91, no. 3 (2023): 30. http://dx.doi.org/10.3390/scipharm91030030.

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This study aimed to prepare tablets of black pepper extract using the Design of Experiments (DOE) approach. The levels of three factors—compressional force, croscarmellose sodium (CCS), and microcrystalline cellulose (MCC)—were screened using the one-factor-at-a-time technique, followed by the DOE utilizing the Box–Behnken design. The respective variations for each factor were as follows: compressional force (1500–2500 psi), CCS (1–3%), and MCC (32–42%). The results indicated that compressional force significantly decreased tablet thickness and friability, while increasing hardness and prolong

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15

Abd Manan, Ezzah, Siti Salwa Abd Gani, Uswatun Hasanah Zaidan, and Mohd Izuan Effendi Halmi. "Formulation and Hardness Evaluation of Tablets Containing Citrus limon and Hylocereus polyrhizus Powder using D-Optimal Mixture Design." Sains Malaysiana 51, no. 10 (2022): 3347–57. http://dx.doi.org/10.17576/jsm-2022-5110-19.

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The powder of mixed fruits that are Lemon (Citrus limon) and Red Pitaya (Hylocereus polyrhizus) was used as a nutritional supplement in tablet form for nutraceutical application. D-optimal mixture experimental design (D-Optimal MED) was employed to investigate the influence of different components on the response hardness of the tablet. For tablet formulation, magnesium stearate, A (0.2-1.0% w/w), menthol, B (0.2-1.0% w/w), lemon powder, C (1.0-10.0 w/w), maltodextrin, D (5.0 -10.0) and glucose, E (37.5-53.1%) are the variables while red pitaya powder and preservative are fixed components. The

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16

Kittipongpatana, Ornanong S., Karnkamol Trisopon, Phanphen Wattanaarsakit, and Nisit Kittipongpatana. "Utilization and Evaluation of Rice Bran and Rice Bran Wax as a Tablet Lubricant." Pharmaceutics 16, no. 3 (2024): 428. http://dx.doi.org/10.3390/pharmaceutics16030428.

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The rice bran and rice bran wax of the KJ CMU107 rice strain were investigated as potential tablet lubricants in a directly compressed tablet formulation. Stabilized full-fatted rice bran (sFFRB), stabilized defatted rice bran (sDFRB), and rice bran wax (RBW) extracted and purified from crude rice bran oil (cRBO) were tested. Two commercial lubricants, including magnesium stearate (MGS) and hydrogenated cottonseed oil (HVO), were employed as the standards in the formulated mixtures, which contained spray-dried rice starch (SDRS) as a diluent. The tableting was carried out for each formulation,

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17

Apsari, Puput Andi, Dewi Nur Eka Sari, Aris Perdana Kusuma, and Oktavia Indrati. "Effervescent Tablet Formulation Melinjo Seed Extract (Gnetum gnemon L.) Using PEG 6000 As Lubricant and Citric Acid - Tartaric Acids As Acid Sources." JURNAL EKSAKTA 18, no. 1 (2018): 30–41. http://dx.doi.org/10.20885/eksakta.vol18.iss1.art4.

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Melinjo seeds (Gnetum gnemonÂ L.) have antioxidant properties one of which is from phenol compounds. However, there is no pharmaceutical dosage form of melinjo seeds especially effervescent tablet. The purpose of this research was to determine the best variation of citric-tartaric acid and PEG 6000 from effervescent tablet of melinjo seed extract. The effervescent tablet of melinjo seed extract were formulated with variation of citric-tartaric acid 25%:75%, 65%:35%, 50%:50%, 20%:80% and PEG 6000 0%, 2%, 3%, up to 5%. The effervescent tablet were made by melting parts of acids and bases, added

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Nurhikmah, Wilda, Erni Rustiani, and Dania Triska Puspita. "PENGEMBANGAN SEDIAAN TABLET ESTROGENIK DARI EKSTRAK RUMPUT KEBAR (Biophytum petersianum) MENGGUNAKAN VARIASI KONSENTRASI PENGIKAT PVP K-30." Jurnal Ilmiah Manuntung 9, no. 2 (2023): 111–19. http://dx.doi.org/10.51352/jim.v9i2.661.

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Kebar grass (Biophytum petersianum Klotzsch) contains steroid, saponins, flavonoids, alkaloids, and triterpenoids. The use of Kebar grass extract can increase the development of follicles because it contains saponins which are the basic ingredients for the synthesis of steroid hormones and can improve the performance of reproductive system. This study aims to determine the quality the tablets made from Kebar grass extract with varying concentrations of PVP K-30 binder. Tablets were made in 3 formulas with varying concentrations of PVP K-30 as a binder, namely 2% (F1), 3% (F2), and 4% (F3). Met

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Rustiani, Erni, Syalsabillah Halizah Wahyono, and Septia Andini. "Formulation and Evaluation of Fast Disintegrating Tablets Containing Broccoli Extract (Brassica oleracea) Using Crospovidone and Ac-Di Sol as Superdisintegrants." FITOFARMAKA: JURNAL ILMIAH FARMASI 14, no. 2 (2024): 132–39. https://doi.org/10.33751/jf.v14i2.23.

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Broccoli (Brassica oleracea) is known to contain flavonoid and glucosinolate compounds that act as acetylcholine enzyme inhibitors to improve memory in humans. To be practical and easy to use, broccoli is made in tablet dosage form. This study aims to determine the effect of the super disintegrants concentration of crospovidone and Ac-Di Sol on the physical quality of the Fast-Disintegrating Tablet (FDT) of broccoli extract. A total of 3 formulas were made using the wet granulation method and different concentrations of crospovidone and Ac-Di Sol, namely formula 1 (crospovidone 5% : Ac-Di-Sol

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Bharat, Jadhav* Rutuja Dhas Sahil T. Shaikh. "EVALUATION OF THE GENERAL MARKETED TABLET." International Journal in Pharmaceutical Sciences 2, no. 2 (2024): 176–83. https://doi.org/10.5281/zenodo.10629019.

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The evaluation of diclofenac potassium tablets involved rigorous testing to ensure quality and efficacy. Tests included hardness assessment to gauge tablet strength, friability testing to determine resistance to action analysis was conducted to ensure uniformity among tablets. This comprehensive evaabrasion, and disintegration tests to assess dissolution properties. Additionally, weight evaluation provides valuable insights into the tablets' physical characteristics, aiding in the assurance of product quality and consistency. This study focuses on the comprehensive evaluation of diclofenac pot

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Patomchaiviwat, Vipaluk, Sontaya Limmatvapirat, Chaisai Sirisapaya, Rohanee Kolae, Kulmanee Anantakul, and Suchada Piriyaprasarth. "Effect of Modified Hydroxypropyl Tapioca Starch and Percentage of Drug Loading on Physical Property of Paracetamol Tablet." Key Engineering Materials 859 (August 2020): 3–8. http://dx.doi.org/10.4028/www.scientific.net/kem.859.3.

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The objective of this study was to investigate the effect of modified hydroxypropyl tapioca starch (HPTS) and % drug loading on physical property of tablet. Paracetamol was used as model drug because of its poor compressibility. The filler ability of modified HPTS such as hydroxyl propyl oxidized tapioca starch (HPOTS), hydroxyl propyl crosslinked tapioca starch (HPCTS) and pregelatinized tapioca starch (PTS) were evaluated and compared with the commercial starch (Starch 1500®). Tablets were prepared by direct compression method and the percent drug loading were 15, 30, 45, 60, 75%. For modifi

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Siti Mursidatur Rohmah, Dewi Rashati,. "UJI FISIK FORMULASI TABLET FLOATING TEOFILIN DENGAN MATRIK HPMC." JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER 1, no. 1 (2021): 13–20. http://dx.doi.org/10.53864/jifakfar.v1i1.6.

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The purpose of this study was to determine the physical properties of theophylline floating tablet formulation with HPMC as matrix. Floating tablets of theophylline is manufactured by direct compression. Composition per tablet formulation consisting of theophylline 270 mg, HPMC, avicel, magnesium stearate, and sodium bicarbonate. The results of data showed average of tablet weight uniformity 501mg, tablet hardness 6,99 kg, tablet friability 0,593%, disintegration time of tablets 738 seconds, floating lag time (FLT) 584,3 seconds and floating duration time (FDT) more than 8 hours. Floating tabl

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Sa'adah, Hayatus. "OPTIMASI FORMULA EKSTRAK JAHE MERAH (Zingiber officinale) DENGAN METODE KEMPA LANGSUNG MENGGUNAKAN ANALISIS SIMPLEX LATTICE DESIGN." Jurnal Ilmiah Manuntung 1, no. 1 (2017): 47. http://dx.doi.org/10.51352/jim.v1i1.11.

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Processing of medicinal plants into the appropriate dosage form can ensure security during use. It is a motivation in making acceptable dosage form which is easy and convenient to use, especially the manufacture of ethanol extract red ginger tablets using a combination of starch 1500 and amprotab.The study begins with the manufacture of dry extract of red ginger. Optimization of making tablets using a combination of starch 1500 and disintegrator with simplex lattice design using three formulas is done by direct compaction method. Further testing on the tablet hardness, friability and disintegr

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RAHMAWATI, TIAS EKA. "Effect of Disintegrating Agents on Red Ginger (Zingiber officinale Roxb) Dry Extract Fast Disintegrating Tablets Using Direct Compression Method." Media Farmasi Indonesia 19, no. 2 (2024): 130–36. http://dx.doi.org/10.53359/mfi.v19i2.278.

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Red ginger (Zingiber officinale Roxb) is one of the medicinal plants that is effective as a medicine for nausea and vomiting. One of the techniques for developing traditional medicinal products is to make fast disintegrating tablets (FDT). This research aims to compare the effect of these various disintegrating materials on the physical properties of FDT. FDT red ginger extract is made using the direct compression method. The tablets obtained were physically evaluated including weight uniformity, hardness, friability, and disintegration time. The statistical results using the one-way ANOVA tes

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Tahaineh, Linda M., and Shadi F. Gharaibeh. "Tablet Splitting and Weight Uniformity of Half-Tablets of 4 Medications in Pharmacy Practice." Journal of Pharmacy Practice 25, no. 4 (2012): 471–76. http://dx.doi.org/10.1177/0897190012442716.

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Background: Tablet splitting is a common practice for multiple reasons including cost savings; however, it does not necessarily result in weight-uniform half-tablets. Objectives: To determine weight uniformity of half-tablets resulting from splitting 4 products available in the Jordanian market and investigate the effect of tablet characteristics on weight uniformity of half-tablets. Methods: Ten random tablets each of warfarin 5 mg, digoxin 0.25 mg, phenobarbital 30 mg, and prednisolone 5 mg were weighed and split by 6 PharmD students using a knife. The resulting half-tablets were weighed and

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Cici Agustin and Arif Wijayanto. "The Formulation And Evaluation Of Metamizole Na Tablet With Porang Tubers(Amorphophallus Oncophyllus) Flour As A Binder." Strada Journal of Pharmacy 6, no. 1 (2024): 55–62. http://dx.doi.org/10.30994/sjp.v6i1.112.

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Many farmers are interested in planting porang tubers, and with many farmers planting porang tubers, the price of porang tubers has decreased at harvest time. Porang tubers contain several ingredients: starch, Glucomannan, fibre, fat, protein, minerals and vitamins. Glucomannan content can be used as a tablet binder, thickener, gelling agent, film former, coating material emulsifier, and stabilizer. This study used the wet granulation method to determine the concentration of porang tuber flour as a binder in Metamizole Na tablets. Tablets were made into three formulations with varying concentr

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Widjayanti, Vinsensia Ivana, and Iwan Setiawan. "Formulasi Tablet Effervescent Ekstrak Sirih Cina (Peperomia pellucida L.) Dan Uji Aktivitas Terhadap Antibakteri Staphylococcus aureus." Pharmacon: Jurnal Farmasi Indonesia 19, no. 2 (2022): 115–25. http://dx.doi.org/10.23917/pharmacon.v19i2.18338.

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Chinese Betel herb (Peperomia pellucida L.) has flavonoid and saponin content compounds that can inhibit bacterial growth. The innovation of effervescent tablets used as disinfectants is not widely known in the Indonesian market. This preparation has the advantage of being easy to manufacture as a disinfectant. Chinese betel herb extract is formulated into an effervescent tablet preparation. This study aims to determine the influence on variations in the levels of binders and fillers in the physical properties of effervescent tablet preparations and determine the activity in the effervescent t

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Nestorovska-Gjosevska, Biljana Nestorovska-Gjosevska, Marija Glavas-Dodov, and Katerina Goracinova. "Orally disintegrating tablet: formulation design and optimisation using Response Surface Methodology." Macedonian Pharmaceutical Bulletin 51 (2005): 15–22. http://dx.doi.org/10.33320/maced.pharm.bull.2005.51.003.

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The objective of this study was to develop diazepam orally disintegrating tablets and to optimize tablets characteristics using response surface methodology (RSM). Tablets were prepared by direct compression of mixture containing mannitol, copovidone, crosspovidone flavor and lubricant. A full factorial design for 2 factors at 3 levels each was applied to investigate the influence of 2 formulation variables on the mechanical strength/hardness, the percent of friability, disintegration time and dissolution of the poorly soluble active ingredient. The amounts of copovidone and crosspovidone were

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Hoa, Vo Thanh, Bui Thi Thu Huong, Do Quang Duong, and Nguyen Duc Hanh. "CAUSE-EFFECT RELATIONS AND OPTIMIZATION OF TABLET CONTAINING EUCOMMIA ULMOIDES AND GARDENIA JASMINOIDES SPRAY-DRIED EXTRACTS." International Journal of Pharmacy and Pharmaceutical Sciences 10, no. 7 (2018): 33. http://dx.doi.org/10.22159/ijpps.2018v10i7.27099.

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Objective: The E. ulmoides and G. jasminoides (EG) tablets containing 67 mg E. ulmoides spray-dried extract (ESE) and 173 mg G. jasminoides spray-dried extract (GSE) were prepared by employing the direct compression method. Due to the poor flowability and compressibility of the two spray-dried extracts, various excipients were added at different ratios so that the blends can be compressed into tablets with the required standards. This study aimed at the cause-effect relations and optimization of the EG tablet formulation.Methods: Different diluents including dibasic calcium phosphate anhydrous

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Setyono, Bambang, and Fahmi Ardianti Purnawiranita. "Analysis of Flow Characteristics and Paracetamol Tablet Hardness Using 2D Double Mixer of Design Drum Type with Rotation and Mixing Time Variations." Journal of Mechanical Engineering, Science, and Innovation 1, no. 2 (2021): 38–48. http://dx.doi.org/10.31284/j.jmesi.2021.v1i2.2282.

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One of the tablet manufacturing processes using the wet granulation method is the process of mixing the active ingredient granules, fillers, binders and pelicans. The parameters of the mixing process are important to study because they will affect the physical properties of the tablet. This study studied the effect of the variable duration and the size of the mixing cycle on the physical properties of paracetamol tablets using a 2D double mixer. The results of the analysis and testing showed that the variation of mixing time and the size of the rotation had a significant effect on the flow pro

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Głogowski, Adrian, Zbigniew Marczyński, Michał Krzysztof Kołodziejczyk, Jerzy Jambor, Marta Kinga Stefan, and Marian Mikołaj Zgoda. "Morphological and pharmacokinetic properties of oral solid dietary supplements containing plant extracts." Herba Polonica 62, no. 3 (2016): 49–62. http://dx.doi.org/10.1515/hepo-2016-0017.

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Summary Introduction: Dietary supplements are a good way to supplement the deficiency of certain micronutrients and organic components (therapeutic agents) in human body. They are most often available in concentrated form as tablets, capsules, powder or liquid. Objective: To investigate morphological parameters and the pharmaceutical availability of coated tablets – dietary supplements – that contain selected pharmacopeial titrated dry plant extracts. Methods: Testing of the effective time of the tablet surface erosion was performed in model acceptor fluids using pharmacopeial methods in stati

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Ermawati, Dian Eka, Rido Rohana Tambunan, and Ulfa Afrinurfadhilah Darojati. "The Effect of Combination of Porang Tuber Starch (Amorphophallus muelleri Blume) with Lactose on the Physical Properties of Bajakah Root (Spatholobus littoralis Hassk) Water Extract’s Tablet." Journal of Pharmaceutical Sciences and Community 21, no. 1 (2024): 17–22. http://dx.doi.org/10.24071/jpsc.005765.

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Kalimantan's people drink bajakah roots as a traditional medicine to restore stamina and treat various diseases. The infusion is less practical and unstable, so it was developed into a tablet. Porang is a local tuber that contains amylum and amylopectin. The combination of starch-lactose has been widely used as a tablet filler and produces tablets with good physical properties. This study aimed to determine the effect of the combination of porang starch-lactose on the granules and tablets' physical properties. Bajakah roots were infused and dried using a freeze-dryer. The antioxidant activity

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Mediterranean, Journal of Pharmacy and Pharmaceutical Sciences. "The impact of tablet shape on quality control parameters for metronidazole tablet marketed in Libya." Mediterranean Journal of Pharmacy and Pharmaceutical Sciences 4, no. 2 (2024): 47–54. https://doi.org/10.5281/zenodo.11477048.

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Worldwide, various metronidazole brands are manufactured and are imported to the Libyan market which are considered pharmaceutically equivalent but may differ in characteristics such as shape, packaging, excipients, etc. This issue has become a valuable topic for researchers due to the lack of information on the effective quality of the tablets about their shapes. The purpose of this study was to assess the pharmaceutical quality of two metronidazole tablet brands with different shapes that are available for purchase in Libya and to figure out how the shape differences impact metronidazole tab

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Huong, Bui Thi Thu, Boonyaphat Monsatta, Nguyen Duc Hanh, Phan Hoang Doan Phuong, and Do Quang Duong. "STUDY ON CAUSE-EFFECT RELATIONS AND OPTIMIZATION OF TABLETS CONTAINING AQUILARIA CRASSNA SPRAY-DRIED EXTRACT." International Journal of Pharmacy and Pharmaceutical Sciences 9, no. 10 (2017): 312. http://dx.doi.org/10.22159/ijpps.2017v9i10.21117.

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Objective: The aim of this study was to develop and optimize the formulation of tablets containing Aquilaria crassna extract using the direct compression method.Methods: D-optimal design based on three independent variables was applied to evaluate the cause-effect relations and optimize the A. crassna tablet formulation. The weight variation (Y1), disintegration time (Y2), hardness (Y3) and friability (Y4) were investigated with respect to three independent variables including % dicalcium phosphate anhydrous (DCPA) in filler (X1), % filler (X2) and % croscarmellose sodium (CCNa) (X3). The diss

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Siddheshwar, Suhas Shivaji, Asmita Bhausaheb Ghorpade, Someshwar Dattatraya Mankar, and Santosh Bhausaheb Dighe. "Formulation and Drug Release Study of Rivaroxaban Oral Disintegrating Tablets Using Various Super-Disintegrants." International Journal of Experimental Research and Review 36 (December 30, 2023): 147–55. http://dx.doi.org/10.52756/ijerr.2023.v36.014.

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This study aims to improve Rivaroxaban's solubility, dissolution, and bioavailability. Orally disintegrating tablets (ODTs) made with super-disintegrants like crospovidone, sodium starch glycolate, and cross-carmellose sodium will do this. Tablet preparation used direct compression and formulation optimization with design expert software. After a thorough factorial design and evaluation of pre- and post-compression parameters, the F3 batch, which contained Rivaroxaban (7.97%), Crospovidone (3.59%), Croscarmellose sodium (5.18%), Sodium Starch Glycolate (5.18%), Lactose Anhydrous (31.08%), Mann

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Macuja, John Carlo O., Laurence N. Ruedas, and Rebecca C. Nueva España. "Utilization of Cellulose from Luffa cylindrica Fiber as Binder in Acetaminophen Tablets." Advances in Environmental Chemistry 2015 (March 31, 2015): 1–8. http://dx.doi.org/10.1155/2015/243785.

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Cellulose is an important pharmaceutical excipient. This study aimed to produce cellulose from the fiber of Luffa cylindrica as an effective binder in the formulation of acetaminophen tablets. This study was divided into three phases, namely, (I) preparation of cellulose from Luffa cylindrica, (II) determination of the powder properties of the LC-cellulose, and (III) production and evaluation of acetaminophen of the tablets produced using LC-cellulose as binder. The percentage yield of LC-cellulose was 61%. The values of the powder properties of LC-cellulose produced show fair and passable flo

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Masih, Ashish, and Ajay Kumar Tiwari. "FORMULATION AND EVALUATION OF FAST DISSOLVING TABLETS OF AMOXYCILLIN TRIHYDRATE AND POTASSIUM CLAVULANATE." International Journal of Current Pharmaceutical Research 9, no. 2 (2017): 48. http://dx.doi.org/10.22159/ijcpr.2017v9i2.17385.

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Objective: The present work is aimed to formulate fast dissolving stable tablet formulation a preferred combination of Amoxycillin trihydrate (Beta-lactum antibiotic) and Potassium clavulanate (Beta-lactum inhibitor) by using various super disintegrants.Methods: Fast dissolving tablets are prepared by direct compression method using super disintegrants i.e. sodium starch glycolate, crospovidone, croscarmellose sodium. Aspartame as a sweetener and trusil mango flavor were used to increase palatability. Reduction in the dose of Amoxycillin trihydrate and Potassium clavulanate tablet was possible

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Patimah, Patimah, Junie Suriawati, and Siti Rahayu Rahmawati. "Development Of Caulis Extract (Tinospora Crispa (L.) Hook. F. & Thomson As Plasmodium In Preparations Tablets." SANITAS : Jurnal Teknologi dan Seni Kesehatan 9, no. 1 (2018): 6–15. http://dx.doi.org/10.36525/sanitas.2018.2.

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Brotowali (Tinospora crispa (L.) Hook. f. Thomson is a wild plant & in the Woods, fields or planted page near the fence, and the usual planted as medicinal plants. The entire plant (roots, stems, and leaves) has a bitter taste that can be used as a traditional medicine as Plasmodium. This research aims to make the tablet dosage of Caulis extract with gelatin Binder and polivenilpirolidon materials that meet the requirements of the physical quality of a tablet that is acceptable. Prior to the manufacture of tablets do extract raw materials testing which includes the determination of the lev

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Sofyah, Titik Mardiyanti, Tukiran Tukiran, and Suyatno Sutoyo. "Antioxidant of Effervescent Tablet Formulated from Combination of Secang Wood and Red Ginger Extracts." Jurnal ILMU DASAR 23, no. 2 (2022): 121. http://dx.doi.org/10.19184/jid.v23i2.28136.

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Secang wood has strong antioxidant properties because it contains phenolic compounds such as flavonoids and brazilin. Also, red ginger has antioxidant derived from nonvolatile phenolic compounds. Until now, there has been no use of a combination of secang wood extract and red ginger specifically for the manufacture of effervescent tablets. The purpose of this study was to formulate an effervescent tablet by doing combination of secang wood and red ginger extracts with using various concentrations of citric and tartaric acids. The formulations conducted were three acid sources of 20%, 25%, 30%,

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Rajni, Dubey1 Saniya Mubarik*2 Bhaskar Kumar Gupta3 Mariya Beg1. "Formulation and Evaluation of By-Layered Tablet." International Journal of Pharmaceutical Sciences 3, no. 3 (2025): 2848–95. https://doi.org/10.5281/zenodo.15101573.

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Several pharmaceutical companies are currently developing bi- layer tablets for a variety of reasons like patent extension, therapeutic efficacy, marketing etc. This technology has been used to reduce capital investment. Modified tablet presses have been used to develop bilayer tablets in order to overcome problems associated with tablets like layer separation, insufficient hardness, inaccurate individual layer weight control, cross contamination between the layers, reduce yield etc. When high production output is required a modified tablet, press is used.

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Drennen, James K., and Randall J. Voytilla. "Non-Destructive Tablet Hardness Testing: The Effect of Moisture on Tablet Hardness Prediction." NIR news 13, no. 4 (2002): 8–9. http://dx.doi.org/10.1255/nirn.669.

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Okafo, Sinodukoo Eziuzo, Emmanuel Agbamu, Ogheneyerhovwome Naomi Bazunu, and Ojogbane Joel Onoja. "Evaluation of the Binding Property of Irvingia Gabonesis Gum in Paracetamol Tablet Formulations Produced using Two Different Disintegrants." INTERNATIONAL JOURNAL OF PHARMACEUTICAL AND BIO-MEDICAL SCIENCE 03, no. 02 (2023): 38–44. https://doi.org/10.5281/zenodo.7599070.

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Paracetamol is mainly used as analgesic and antipyretic drug. This study was conducted to evaluate the binding property of Irvingia gabonensis gum (IGG) in paracetamol tablet formulations in the presence of either maize starch or microcrystalline cellulose as disintegrant. IGG was isolated by acetone precipitation of the filtrate from the maceration of the powdered seeds of Irvingia gabonensis (Irvingiaceae) in distilled water for 24 h. Paracetamol granules were prepared using the wet granulation method. They were produced by using various concentration of IGG as binder, maize starch or microc

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Nur Cahyani, Arinda, Adi Susanto, Iva Rinia Dewi, and Iswatun Nurhikmah. "FORMULASI TABLET PARASETAMOL DENGAN KOMBINASI PVP DAN AMILUM UMBI PORANG (Amorphopallus onchopyllus) SEBAGAI BAHAN PENGIKAT TERHADAP SIFAT FISIK TABLET." Jurnal Ilmiah JOPHUS : Journal Of Pharmacy UMUS 4, no. 02 (2023): 1–11. http://dx.doi.org/10.46772/jophus.v4i02.886.

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Tablets are the most widely used preparations, this is because tablets have advantages that other pharmaceutical preparations do not have, both in terms of production, storage, distribution, and use. This study aims to determine the concentration of PVP and starch from porang tubers which can be used as a binder in the preparation of paracetamol tablets and to determine the combination of PVP and starch from porang tubers as a binder to the physical properties of paracetamol tablets. In this study, 4 paracetamol tablet formulas with PVP binder were made combined with porang tuber starch with a

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Gorski, Stanley F. "Slow-Release Delivery System for Herbicides in Container-Grown Stock." Weed Technology 7, no. 4 (1993): 894–99. http://dx.doi.org/10.1017/s0890037x00037957.

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Metolachlor, applied to the surface of leaching columns as dicalcium phosphate tablets, was recovered over a period of 25 d compared with 2 and 3 d for emulsifiable concentrate and granular formulations, respectively. In similar studies, approximately 27% of napropamide was recovered from tablets during the same period. Adding an adjuvant to the napropamide tablet mixture increased the recovery rate to 55%. Tablet hardness and size had little effect on the release rate of napropamide. Tablets containing 4% ai napropamide released greater amounts of herbicide at a single collection period than

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Tampubolon, Stephanie Angelica Rinjani, Marvel Reuben Suwitono, and Titin Sulastri. "Development of Conventional Tablets from Herbal Extracts of Jati Belanda, Kumis Kucing, Meniran, Sirih, and Turmeric for Body Weight Reduction." Jurnal Biologi Tropis 24, no. 4 (2024): 1034–39. https://doi.org/10.29303/jbt.v24i4.8020.

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Health problems that occur today are diverse and varied, one of which is being overweight. This study focuses on the formulation of herbal extracts in conventional tablet preparations using Jati Belanda, Kumis Kucing, Meniran, Sirih, and Kunyit which have the potential as weight loss agents. Extraction is carried out using the maceration method, then the extract is made into conventional tablets with additional ingredients: magnesium stearate, talc, PVP, Avicel pH 102, and aerosil. Evaluation of physical properties such as uniformity of size, uniformity of weight, hardness, and disintegration

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Samprasit, Wipada, Praneet Opanasopit, Prasert Akkaramongkolporn, Tanasait Ngawhirunpat, Kaewnapa Wongsermsin, and Suwannee Panomsuk. "Formulation of Dextromethorphan Oral Disintegrating Tablet Using Ion Exchange Resin." Advanced Materials Research 201-203 (February 2011): 1384–87. http://dx.doi.org/10.4028/www.scientific.net/amr.201-203.1384.

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The purpose of this research was to mask the bitter taste of dextromethorphan hydrobromide using a cationic ion exchange resin, Amberlite® IRP-69, to formulate oral disintegrating tablets (ODTs). The drug was loaded (resinate) were prepared in drug to resin ratio of 1:1 and 1:2. The resinate or physically mixed with the resin (physical mixture) was incorporated into ODTs by direct compression. The formula was developed to acquire the optimal formulations of taste masked ODTs, hardness and mouth feel and disintegration time. The ODTs were further evaluated for weight, friability, disintegration

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Lynatra, Cessa, Wardiyah Wardiyah, and Yetri Elisya. "Formulation Of Effervescent Tablet Of Temulawak Extract (Curcuma xanthorrhiza Roxb.) With Variation Of Stevia As Sweetener." SANITAS : Jurnal Teknologi dan Seni Kesehatan 9, no. 2 (2018): 72–82. http://dx.doi.org/10.36525/sanitas.2018.9.

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The effervescent tablet containing extract of temulawak (Curcuma xanthorrhiza Roxb.) with variation of stevia sweetener has been formulated using wet granulation method. This research aims to find the formulation of effervescent tablet of temulawak extract (Curcuma xanthorrhiza Roxb.) with the variation of stevia sweetener that meets the requirements of physical tablet test. The effervescent tablet formula was made in three formulas with the difference in the stevia content. Tests conducted include visual tests, uniformity test, hardness test, friability test, pH test and solubility test. Base

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Haryono, Ika Avrilina, and Noval Noval. "Formulasi dan Evaluasi Tablet Effervescent dari Ekstrak Buah Tampoi (Baccaurea macrocarpa)." Jurnal Surya Medika 7, no. 2 (2022): 34–44. http://dx.doi.org/10.33084/jsm.v7i2.3201.

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Tampoi is one of the many plants found in East Kalimantan, has secondary metabolic content in the form of saponins, flavonoids, and alkaloids, and has antioxidant activity. The antioxidants produced by the human body are not sufficient to fight free radicals, therefore the body requires the intake of antioxidants from the outside, so to help increase public interest in consumption, researchers are interested in making preparations in the form of extracts and formulated as effervescent tablets from tampoi fruit extract which are useful as antioxidants and increase immunity. The purpose of this

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Paul, Souvik, Tanmoy Dey, Prabin Koirala, Sidhant Tamang, Soumik Bhattacharya, and Rajat Das. "Formulation and evaluation of Polyherbal tablet by using Neem, Tulsi, Turmeric and Ginger extract." Journal of Drug Delivery and Therapeutics 13, no. 7 (2023): 46–51. http://dx.doi.org/10.22270/jddt.v13i7.5895.

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Introduction: Cold and cough is the common disease condition which effects patient of every age. The treatment approach of medicinal herbs has been recognized for many decades and even longer for the treatment and prevention of cold and cough. The aim of the study was to evaluate the safety and efficacy of polyherbal tablet. Polyherbal tablet containing herbs like Neem (Azadirachta indica), Tulsi (Ocimum tenuiflorum), Ginger (Zingiber officinale), Turmeric (Curcuma longa) is used for curing cold and cough. This tablet formulation reduces the healing time for sore throat and boost up the immuni

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Karmakar, Palash, and Md Golam Kibria. "In-vitro comparative evaluation of quality control parameters between paracetamol and paracetamol/caffeine tablets available in Bangladesh." International Current Pharmaceutical Journal 1, no. 5 (2012): 103–9. http://dx.doi.org/10.3329/icpj.v1i5.10282.

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Paracetamol is a widely used non-prescription analgesic and antipyretic medicine. The study was conducted to assess the comparative in-vitro quality control parameters through the evaluation of weight variation, hardness, friability, disintegration time and dissolution profile between the commercially available tablet brands of paraceta-mol and paracetamol/caffeine combination in Bangladesh. Tablets of five top level manufacturers those have both of the formulations were evaluated in two groups. Both similarities and dissimilarities were found between the groups. All tablets either paracetamol

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