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Mao, Kangyi. "Microstructural investigation of tablet compaction and tablet pharmacological properties." Thesis, Massachusetts Institute of Technology, 2010. http://hdl.handle.net/1721.1/62108.
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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, 2010.Cataloged from PDF version of thesis.
Includes bibliographical references.
In current tablet manufacturing processes, there is a knowledge gap concerning material transformation and the subsequent impact on tablet properties; this gap presents a barrier to rational formulation / process design. In this study, it was hypothesized that the understanding of tablet microstructure is pivotal in bridging our knowledge about the materials, the manufacturing process, and the tablet properties. A series of X-ray micro computed tomography (microCT) characterization methods were developed to untangle material interactions during tablet manufacturing process, leading to an interpretation of tablet compaction mechanisms through 3-D representation of microstructural features. Numerical simulation of liquid intrusion based on microCT data was utilized in calculating tablet microstructure permeability, introducing a novel parameter for characterization of tablet dissolution properties. A tablet holder was designed and used in combination with paddle dissolution test to investigate tablet dissolution process, enabling the classification of dissolution mechanisms and identification of correspondent formulation design strategies. When incorporated with permeability results, a quantitative dissolution model capable of separating the contributions from disintegration and surface dissolution was derived. The dissection of the dissolution process provides a scientific framework supporting the Quality by Design paradigm for product and process development. . This work provides a strategy for building an integrated formulation design and characterization system incorporating microstructural analysis. It opens up an approach in which microstructure becomes a critical target for design and optimization.
by Kangyi Mao.
Ph.D.
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De, Oliveira Serge, and Solís Patricio Jara. "Lanzamiento tablet öwn." Tesis, Universidad de Chile, 2014. http://www.repositorio.uchile.cl/handle/2250/130138.
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Teiis para optar al grado de Magíster en MarketingDe Oliveira, Serge (Parte I), Jara Solís, Patricio (Parte II)
De acuerdo a la tercera versión del Índice de Desarrollo Digital (IDD), presentado por la consultora IDC Chile y la Asociación Chilena de Empresas de Tecnología de Información (ACTI), Chile es hoy en día uno de los países de mayor crecimiento de la región en cuanto a inversión en Tecnologías de la Información y Comunicaciones (TIC). Un alza que se viene manteniendo desde 2010 y que también se proyecta para 2014. Los Smartphone y Tablet son los que generan los mayores niveles de aumento en este ámbito y según el mismo estudio, la industria de computadores decreció en 2013, siendo sobrepasado por la irrupción masiva de los Tablet. En una entrevista hecha por el diario La Tercera, Jaime Soto, presidente de la ACTI indicó que “las ventas de Tablet casi fueron triplicadas durante el período comprendido entre los años 2012 y 2013”. Estos antecedentes son un claro indicador de que Chile está entrando en la era "post PC". No solamente porque los tablets aumentaron sus ventas, sino que porque Chile alcanzó el primer lugar de penetración de esta tecnología en toda la región con cerca del 6% de la penetración de mercado, el doble de los países que le siguen, como Brasil y México, donde si bien se venden más unidades, la proporción con sus mercados locales es sólo del 3%. Es en este contexto es que ÖWN, marca real muy poco conocida en la actualidad (nacida recién en el mes de Noviembre de 2013), decide lanzar su primer tablet en el mercado local. Si bien esta marca tiene unas diéresis nórdicas, es 100% chilena y no es otra cosa que la marca propia de la empresa Entel, la cual responde a una estrategia para permitir a segmentos socioeconómicos más bajos acceder a la tecnología y a la vez a la conectividad móvil. En la actualidad, ÖWN comercializa sólo teléfonos en Chile y Perú, utilizando los canales de distribución de Entel (tiendas propias, franquicias, Retail, etc.) con una propuesta de valor apalancada en una ventaja competitiva en términos de Costo y Diferenciación, enfocada a captar al “joven social”
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Золотова, Світлана Григорівна, Светлана Григорьевна Золотова, Svitlana Hryhorivna Zolotova, and S. O. Chernenko. "Tablet personal computer." Thesis, Вид-во СумДУ, 2011. http://essuir.sumdu.edu.ua/handle/123456789/22212.
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Schabos, Julia. "Ting, Twitter und Tablet." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-155888.
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In der Leseförderung spielen klassische Medien eine wesentliche Rolle, werden aber zunehmend durch digitale Angebote ergänzt. Das Projekt „Lesen macht stark: Lesen und digitale Medien“ greift diese Entwicklung auf. Es bietet Bibliotheken mit fünf altersgerechten Aktionen die Gelegenheit, bewährte Veranstaltungsformate digital anzureichern und cross-medial zu arbeiten, denn Text- und Medienkompetenz sind wesentliche Voraussetzungen für die Meinungs- und Persönlichkeitsbildung von Kindern und Jugendlichen. Über die Nutzung neuer Medien erhalten sie die Möglichkeit, Inhalte selbst zu gestalten – sei es über das Internet, Smartphones oder Tablet-PCs. Ausgangspunkt bleibt immer ein gelesener Text, der mit digitalen Medien weiterentwickelt wird. So sollen auch Kinder und Jugendliche im Alter von drei bis 18 Jahren Spaß am Lesen entwickeln, die nicht von Haus aus dazu animiert werden.
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Inman, Sharon. "Cellulose bilayer tablet interfaces." Thesis, Imperial College London, 2008. http://hdl.handle.net/10044/1/11775.
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Graben, Roger Dale Parsons Daniel L. "Promethazine orally disintegrating tablet." Auburn, Ala., 2006. http://hdl.handle.net/10415/1317.
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Becker, Jane A. "Optimizing the touch tablet: the effects of lead-lag compensation and tablet size." Thesis, Virginia Polytechnic Institute and State University, 1986. http://hdl.handle.net/10919/94450.
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A major design aspect of touch tablet operation is the display/control (D/C) gain. The primary objective of this research was the development and optimization of a variable D/C gain to improve human performance with touch tablets. This variable gain minimizes the speed-accuracy trade-off problem associated with traditional D/C gains. An additional objective.of this research was to determine the effect of tablet size on human performance.
Display/control (D/C) gain is defined as the amount of movement which occurs on the display in response to a unit amount of movement of the control. With traditional D/C gains, there is a trade-off between low D/C gain which enables fine positioning, but results in very slow cursor movement, and high D/C gain which produces quick cursor movement but results in poor fine positioning ability. A lead-lag compensator which ameliorates this trade-off problem was developed. A lead-lag compensator is composed of a pure position gain component plus an additional velocity gain component.
The results indicate that a lead-lag compensator greatly increased the target acquisition rate relative to a traditional D/C gain system.
Percentage error increased with lead-lag compensation relative to an uncompensated system. The overall error rates were very low in all cases, however.
Tablet size did not appear to significantly affect performance; performance on the three tablet sizes was generally consistent.M.S.
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Gabrielsson, Jon. "Multivariate methods in tablet formulation." Doctoral thesis, Umeå : Univ, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-268.
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Zinchkovska, N. L., and O. A. Zvonok. "The tablet on a string." Thesis, КНУТД, 2016. https://er.knutd.edu.ua/handle/123456789/5048.
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Xu, Henrik. "Tablet application GUI usability checklist : Creation of a user interface usability checklist for tablet applications." Thesis, Södertörns högskola, Institutionen för naturvetenskap, miljö och teknik, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:sh:diva-19168.
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Since the beginning of the 21st century, the world has seen a changing trend in computing power thanks to advancements in technology. One peculiar platform in the field of usability is the tablet. Due to its recent introduction, it has had a relatively short life span with few established methodologies. The tablet is gaining market share at a tremendous speed and thus there has been a big demand of the appropriate evaluation methods. This comprehensive study intention is to; through a literature survey and transformation of collected material identify what usability requisites there are when developing a user interface for a tablet application. Existing user interface guidelines from various companies involving the development of tablet software are examined and paired up with usability principles in the creation of the usability checklist. The usability checklist practical effectiveness is tested on various tablet applications and the results are compared to the results of a usability user test valuation. The majority of the usability problems found by the user test evaluation are codiscovered, in addition, there were a greater number of undiscovered usability problems that was identified with the checklist evaluation.
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Ribeiro, Alexandre de Souza. "Ergonomia de tablets em uso ocupacional : atividade visual e biomecânica postural sob a influência de ofuscamentos reflexivos causados pela iluminação /." Bauru, 2014. http://hdl.handle.net/11449/126290.
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Orientador: João Roberto Gomes de FariaBanca: Luiz Carlos Paschoarelli
Banca: Lígia Maria Presumido Braccialli
Resumo: Atualmente, pesquisas sobre ergonomia relacionada à iluminação do ambiente não estão restritas à concepção qualitativa de condições visuais, vertentes apontam para a importância de considerar os impactos biológicos da interação com a luz. Com a recente e próspera implementação do uso ocupacional do tablet, em ambientes escolares e de trabalho, pouca atenção tem sido dada aos princípios ergonômicos neste processo, ao mesmo tempo, em que surgiram diversas problemáticas ergonômicas. A abordagem desta pesquisa surgiu da hipótese de que a ambiência luminosa comumente encontrada não é adequada para atividades com terminais de vídeo no plano horizontal, ou próximo deste. A interação com a interface altamente reflexiva do tablet tende a gerar ofuscamento por reflexão, o qual pode comprometer o desempenho da atividade de varredura visual, bem como levar a compensações posturais inadequadas em função da busca por uma melhor condição visual. Neste contexto, o objetivo foi analisar o uso ocupacional do tablet quando à influência do ofuscamento refletivo sobre o desempenho da atividade de varredura visual e biomecânica postural da região cervical da coluna vertebral. A pesquisa foi desenvolvida com 20 participantes, com idade média de 20,2 anos, quais realizaram tarefa prescrita de observação visual de optótipos e verbalização de sua direção, sujeitos a áreas com e sem ofuscamento refletido na interface do tablet. Para a coleta de dados foram utilizados sistemas eye tracker e head tracker integrados, o primeiro aplicado à análise da atividade de varredura visual, representa pelo comportamento da linha do olhar horizontal e o segundo para aferir a biomecânica postural da coluna cervical, por meio da análise cinemática dos movimentos da cabeça (posição - coordenadas nos eixos X, Y e Z) e (orientação - ângulos azimuth, elevation e roll). Os dados foram tratados no Matlab e submetidos à análise...
Abstract: With the recent and successful implementation of the occupational use of the digital tablet in school and work environmentas. With the recent and successful implementation of the accupational use of the tablet in school and work enviornments, little attention has been palid to ergonomic principles in this process at the same time, in which several ergonomic problems have arisen. The approach of this research came from the hypothesis tha the ambience commonly found is not suitable for activities with videos terminals in the horizontal plane, or close to this. The interaction with the highly reflexive interface of the tablet tends to generate glare by reflection, wich can compromise the performance of the visual exploration activity, as well as lead to inappropriate postural compensations due to the searc for better visual condition. In this context, the objective was analyze the occupational use of the tablet how much the influence of glare by reflection about the performance of the visual exploration activity and postural biomechanics of the cervical region of the spine. The research was developed with 20 participants with a mean age of 20.2 years, who underwent the prescribed task of visual observation of optatypes and verbalization of their direction, subjected the areas with and without glare by reflection in the tablet interface. To the collect of data were used integrated systems of tracking of the eye and of the head, the first applied to the analysis of visual exploration activity, represented by the behavior of the live of the horizontal gaze and the second to measure the postural biomechanics of cervical spine by kinematics analysis of head movements (position - coordinates of the axes, X, Y and Z) and (orientation - angles of rotation, azimuth, elevation and roll). The data were treated at the Matlab and subjected to statistical analysis (ANOVA one-way for repeated measures) for the effect of glare, with three levels (before...
Mestre
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Ribeiro, Alexandre de Souza [UNESP]. "Ergonomia de tablets em uso ocupacional: atividade visual e biomecânica postural sob a influência de ofuscamentos reflexivos causados pela iluminação." Universidade Estadual Paulista (UNESP), 2014. http://hdl.handle.net/11449/126290.
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000838257.pdf: 2769841 bytes, checksum: 7644e009d8c33c39ebaa5bf3b52be814 (MD5)Atualmente, pesquisas sobre ergonomia relacionada à iluminação do ambiente não estão restritas à concepção qualitativa de condições visuais, vertentes apontam para a importância de considerar os impactos biológicos da interação com a luz. Com a recente e próspera implementação do uso ocupacional do tablet, em ambientes escolares e de trabalho, pouca atenção tem sido dada aos princípios ergonômicos neste processo, ao mesmo tempo, em que surgiram diversas problemáticas ergonômicas. A abordagem desta pesquisa surgiu da hipótese de que a ambiência luminosa comumente encontrada não é adequada para atividades com terminais de vídeo no plano horizontal, ou próximo deste. A interação com a interface altamente reflexiva do tablet tende a gerar ofuscamento por reflexão, o qual pode comprometer o desempenho da atividade de varredura visual, bem como levar a compensações posturais inadequadas em função da busca por uma melhor condição visual. Neste contexto, o objetivo foi analisar o uso ocupacional do tablet quando à influência do ofuscamento refletivo sobre o desempenho da atividade de varredura visual e biomecânica postural da região cervical da coluna vertebral. A pesquisa foi desenvolvida com 20 participantes, com idade média de 20,2 anos, quais realizaram tarefa prescrita de observação visual de optótipos e verbalização de sua direção, sujeitos a áreas com e sem ofuscamento refletido na interface do tablet. Para a coleta de dados foram utilizados sistemas eye tracker e head tracker integrados, o primeiro aplicado à análise da atividade de varredura visual, representa pelo comportamento da linha do olhar horizontal e o segundo para aferir a biomecânica postural da coluna cervical, por meio da análise cinemática dos movimentos da cabeça (posição - coordenadas nos eixos X, Y e Z) e (orientação - ângulos azimuth, elevation e roll). Os dados foram tratados no Matlab e submetidos à análise...
With the recent and successful implementation of the occupational use of the digital tablet in school and work environmentas. With the recent and successful implementation of the accupational use of the tablet in school and work enviornments, little attention has been palid to ergonomic principles in this process at the same time, in which several ergonomic problems have arisen. The approach of this research came from the hypothesis tha the ambience commonly found is not suitable for activities with videos terminals in the horizontal plane, or close to this. The interaction with the highly reflexive interface of the tablet tends to generate glare by reflection, wich can compromise the performance of the visual exploration activity, as well as lead to inappropriate postural compensations due to the searc for better visual condition. In this context, the objective was analyze the occupational use of the tablet how much the influence of glare by reflection about the performance of the visual exploration activity and postural biomechanics of the cervical region of the spine. The research was developed with 20 participants with a mean age of 20.2 years, who underwent the prescribed task of visual observation of optatypes and verbalization of their direction, subjected the areas with and without glare by reflection in the tablet interface. To the collect of data were used integrated systems of tracking of the eye and of the head, the first applied to the analysis of visual exploration activity, represented by the behavior of the live of the horizontal gaze and the second to measure the postural biomechanics of cervical spine by kinematics analysis of head movements (position - coordinates of the axes, X, Y and Z) and (orientation - angles of rotation, azimuth, elevation and roll). The data were treated at the Matlab and subjected to statistical analysis (ANOVA one-way for repeated measures) for the effect of glare, with three levels (before...
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Lönroth, Lisa. "Tablet-based interaction methods for VR." Thesis, Linköpings universitet, Institutionen för teknik och naturvetenskap, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-97142.
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Interaction with virtual environments has for a long time been a subject of research and many different techniques and interaction-devices have been developed. Both 3D interaction devices such as wands, gloves etc are in use, but also traditional 2D interaction with a mouse and a keyboard exist. In this work we explore the possibility to use a TabletPC as an interaction-device for virtual environments. Several methods of interaction for tasks like selection and value manipulation were developed, using the human ability of spatial knowledge as an aid. The methods have been developed to suit a pen-based interface and the special features of the pen have been taken under consideration. Evaluation showed that the developed interaction methods were usable.
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Sadjady, Seyed Kazem. "A study of tablet lubricant behaviour." Thesis, Liverpool John Moores University, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.262273.
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Marwaha, S. B. "A study of tablet lubricant behaviour." Thesis, Liverpool John Moores University, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.375096.
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Ho, A. Y. K. "Time dependent characteristics in tablet compaction." Thesis, Open University, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.375495.
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A single punch tablet machine has been instrumented to measure top and bottom punch force and punch displacement. A system has been developed for instrumenting rotary tablet machines using radio telemetery techniques and compared with conventional instrumentation systems. It is shown that the positioning of the measuring devices is critical for accurate measurements of forces and punch displacement. Samples of Micro crystalline cellulose (Avicel PH-102) and various grades of Lactose have been characterised and their compaction properties measured by a variety of techniques including breaking strength, changes in bed density under compaction and stress relaxation. The properties were determined using a specially constructed laboratory compaction simulator capable of reproducing compaction events typical of full scale production. It is shown that none of the conventional indices of compaction behaviour adequately predict the compaction properties of materials as described by their breaking strength: force profile. A phenomenon is described whereby the measurement of maximum force is not coincidental with the measurement of maximum punch penetration. Using model materials it is suggested that these differences are due to the visco elastic and plastic components of materials during compression. A new index - rise time - (the time between the initiation of compression and the point of maximum force application) is proposed as a useful means of predicting the behaviour of pharmaceutical solids during compression.
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Ostroumov, Ivan Victorovich. "Tablet location tracking by inertial sensors." Thesis, ІІI National Scientific Conference of young scientists and students «Problems and prospects of Aeronautics and Astronautics» 23 – 24 October 2014 y – Kyiv, 2014. – P. 13, 2014. http://er.nau.edu.ua/handle/NAU/26586.
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Position detection is one of the key tasks of navigation. Nowadays positioning market represented by different positioning techniques. The main of them for typical
civil users is Global Navigation Satellite System which has global coverage but limited
for usage in close area (buildings). Telecommunication network also using for
positioning purpose but for urban area, this approach not accurate because radio wave
reflects from buildings and produce valuable errors. In this case inertial navigation
principle can help.
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Minchom, Colin Michael. "Objective criteria for directly compressible tablet fillers." Thesis, Cardiff University, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.276882.
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Neves, João António Tavares. "Aplicações de periódicos desenvolvidas para o tablet." Master's thesis, Instituto Politécnico de Tomar, 2013. http://hdl.handle.net/10400.26/5797.
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O presente relatório divide-se em duas partes. Na primeira é feita uma breve descrição do estágio realizado no estúdio Cases i Associats, com alguns dos projectos desenvolvidos por mim. Na segunda parte é desenvolvido o tema deste relatório, aplicações de periódicos desenvolvidas para o tablet.
Como tal, em relação ao tema, é feita uma introdução ao tablet, onde é descrito as características e as potencialidades deste suporte, passando pela apresentação da nova interface do utilizador e das reacções dos utilizadores a este novo dispositivo. De seguida é feita uma análise às primeiras aplicações de periódicos, com uma breve descrição das suas funcionalidades. Ainda dentro deste tema é dado especial destaque à aplicação The Daily, o primeiro jornal exclusivo para o tablet.
A importância da publicidade e as estratégias de venda das aplicações são também temas abordados neste relatório. Posteriormente são apresentados os conceitos base para o design destas aplicações, bem como o tipo de conteúdos que devem disponibilizar.
Como conclusão deste relatório, é analisado uma aplicação que tira partido das potencialidades do tablet e representa o que devem ser as publicações neste dispositivo. A referida aplicação é do jornal O Globo (Brasil), com destaque para o produto O Globo a Mais, a revista exclusiva para tablet.
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Sakandelidze, Alexander. "Consumers' Experience of Advertisements in Tablet Devices." Thesis, Internationella Handelshögskolan, Högskolan i Jönköping, IHH, Företagsekonomi, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-18234.
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Jonsson, Jonathan. "Exploring destinations with atouch based tablet application." Thesis, Umeå universitet, Institutionen för tillämpad fysik och elektronik, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-89796.
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The mobile technology that emerged with the smartphones and tablets has changed the way people travel. This has changed both in how bookings are performed, but also in the way travel destinations are browsed and explored. This thesis concerns the design and implementation of a prototype for exploring destinations, with the goal of finding out the most essential factors and parameters for travel browsing. With literature studies, user survey, paper prototyping and Hi-Fi prototypes, an implementation was made, written in Objective C and created as an iPad prototype. The application uses a globe-, map-, image- and list view as the main interfacesfor browsing destinations. The prototype uses 14 di↵erent APIs, with diverse functionality to be able to take advantage of searching and filtering of destinations, made available by the APIs. By incorporating social platforms, it was made possible to better target the user’sinterest, making the experience and exploration more personalized.
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Pore, Mridula. "Pharmaceutical tablet compaction : product and process design." Thesis, Massachusetts Institute of Technology, 2007. http://hdl.handle.net/1721.1/51623.
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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, 2009.Includes bibliographical references.
This thesis explores how tablet performance is affected by microstructure, and how microstructure can be controlled by selection of excipients and compaction parameters. A systematic strategy for formulation and process design of pharmaceutical tablets is proposed. A modified nanoindenter method was used to test the mechanical behavior of diametrally compressed excipient granules. X ray micro computed tomography and Terahertz pulsed spectroscopy (TPS) and imaging (TPI) were used to analyze the microstructure of the tablet core and detect internal defects. Granule failure mechanisms are found to be consistent with tablet microstructure. MCC granules deform plastically when tested and X ray images show individual granules undergoing increasing deformation in tablets as higher compaction forces are used. A highly interconnected pore-structure limited tablet hardness and led to bursting behavior during dissolution. No effect of compaction force or speed was observed in dissolution profiles. Lactose granules fracture at strains less than 5%, forming monolithic structures with no evidence of initial granule shape or size. Pore size decreases as compaction force is increased for DCL 11 tablets. A decreasing pore size corresponds to increasing THz refractive index, tablet hardness and dissolution time. DCL 11 and DCL 14 tablets compacted under the same conditions have the same pore size distributions and hardness, although DCL 14 granules are weaker than DCL 11, and DCL 14 tablets dissolve up to four times slower than DCL 11 tablets. No difference was observed between the THz spectra of tablets made from the two grades of lactose.
(cont.) Further work is needed to understand the physical significance of the THz measurements. TPI can detect laminated tablets and is faster than X ray micro CT. In order to develop a rational design methodology, two key areas for future research are building a process model for compaction and developing quality testing methods that can be analyzed mechanistically. The capstone project explores strategic decision making for innovator firms and generic drug manufacturers in the period surrounding patent expiry. Statin products were used as an illustrative case of a pharmaceutical technology experiencing commoditization. A system dynamics model was used to simulate historic results and explore options for products still under patent protection. Current models of technology market dynamics apply to statins, but regulation and legislation play a large role in controlling market entry, leading to strong sequencing effects.
by Mridula Pore.
Ph.D.
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Sondej, Nicholas Matti. "Direct tablet formation by electrospinning and compaction." Thesis, Massachusetts Institute of Technology, 2014. http://hdl.handle.net/1721.1/100885.
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Thesis: S.M., Massachusetts Institute of Technology, Department of Mechanical Engineering, 2014.Cataloged from PDF version of thesis.
Includes bibliographical references (page 107).
A process and physical system were developed to manufacture pharmaceutical tablets through an electrospinning operation and subsequent compaction. Theoretical simulations of the electrospinning were run to predict physical system performance, and a proof-of-concept device was designed, produced and tested. The process was demonstrated to be theoretically scalable to levels of production suitable for industrial pharmaceutical manufacturing. The system demonstrated clear advantages over preexisting pharmaceutical manufacturing equipment, eliminating airborne drug particulate matter, minimizing liquid drying time, and enabling a more agile, liquid-based continuous manufacturing process to be utilized for pharmaceutical production. Future work was specified to refine and optimize the process, and improve process control and monitoring in order to meet the pharmaceutical industry's strict regulatory controls.
by Nicholas Matti Sondej.
S.M.
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SCHULZE, NAHRUP JULIA. "EVALUATION OF SILICONE ELASTOMERS FOR TABLET COATING." University of Cincinnati / OhioLINK, 2003. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1052939931.
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Barreto, Marcelo Vatam. ""The e-book is on the tablet"." reponame:Repositório Institucional da UFSC, 2016. https://repositorio.ufsc.br/xmlui/handle/123456789/176014.
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Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Educação, Programa de Pós-Graduação em Educação, Florianópolis, 2016.Made available in DSpace on 2017-05-30T04:11:44Z (GMT). No. of bitstreams: 1 345643.pdf: 4901819 bytes, checksum: 8c32efeffce680ecc469a8341197f507 (MD5) Previous issue date: 2016
As tecnologias digitais já fazem parte de nosso cotidiano e estão presentes nas várias esferas de nossas vidas, seja ela social, cultural, econômica, religiosa, entre tantas outras. No entanto, apesar das mídias já estarem presentes e influentes na sociedade, questiona-se por que a escola ainda não integrou definitivamente a cultura digital em seu cotidiano pedagógico. A partir desse questionamento, a presente dissertação pretende refletir sobre as mudanças trazidas pelas mídias no campo da educação, tendo em vista a escola como um espaço que oportuniza a transformação social (e que está, portanto, preocupada com a formação de sujeitos autônomos, ativos e críticos) e que não pode ignorar o processo complexo e dinâmico pelo qual passa a sociedade atual. Mais especificamente, buscaremos analisar a formação inicial do professor de inglês orientado à integração das mídias no contexto do Estágio Curricular Supervisionado. Entendemos que os avanços tecnológicos nas últimas décadas, assim como os processos globais que derivam desses avanços, situam o ensino e a aprendizagem da língua inglesa e a integração das mídias em contextos pedagógicos como temas relevantes na atualidade. Isso dito pretende-se investigar o conhecimento e uso das mídias digitais que os sujeitos desta pesquisa ? 14 licenciandos do curso de Letras Inglês da UFSC ? possuem ao concluir a formação teórica e ingressar no estágio de docência, e como esse letramento digital é utilizado durante o practicum. Para realizarmos esta investigação utilizamos a abordagem metodológica do estudo de caso, a observação participante, e instrumentos inspirados na pesquisa etnográfica aliada a abordagens do tipo qualitativo e quantitativo. Contamos também com as contribuições de autores de várias áreas do conhecimento. Na área de letramento e mídia-educação nos debruçamos em Belloni, Knobel, Lankshear, Soares entre outros; sobre a formação de professores e estágio de docência nos referenciamos aos textos de Alvarez, Pimenta, e Wielewicki. Warchauer e seu expertise sobre o CALL (Computer-Assisted Language Learning) nos auxiliou na compreensão da evolução do uso de tecnologias e as metodologias associadas no ensino de inglês. Concluímos ser o estágio de docência o momento em que os professores em formação encontram as condições favoráveis, i.e. apoio pedagógico, apoio institucional, estrutura física da escola, turmas de alunos, entre outras condições, e dessa forma podem colocar em prática seus saberes de docência de forma experimental e segura. Nesse contexto, observamos que a inserção de mídias em atividades pedagógicas durante o practicum foi considerado por vários futuros professores sob duas perspectivas: como um instrumento valioso no apoio do ensino da língua inglesa e também pelo seu caráter cultural. No primeiro caso, a internet e as mídias disponibilizaram materiais autênticos, interessantes e relevantes ao contexto dos educandos. Como objeto cultural, as mídias foram percebidas como parte da cultura digital em que a maioria dos jovens já faz parte (cibercultura). Grande parte dos alunos mostrou estar familiarizados com a utilização e interação em diferentes ambientes on-line. Nesse sentido, a integração de mídias em contextos pedagógicos teve por objetivo aproximar a cultura praticada pelos alunos fora da escola para dentro da sala de aula, com atividades mais atraentes, dinâmicas e que promovessem a aprendizagem da língua inglesa de forma colaborativa, divertida e significante para os educandos.
Abstract : Digital technologies are already part of our daily life and are present in various spheres, be it social, cultural, economic, religious, among many others. However, in spite of the medias being already present and influential in our society, it is questioned why the school has not yet effectively integrated the digital culture in its pedagogical practice.From this questioning, the present dissertation intends to reflect on the changes brought about by the media in the field of education, considering the school as a space which provides opportunities for social changes (and it is therefore concerned with the formation of autonomous, active and critic individuals), and cannot ignore the complex and dynamic process to which the current society is going through. More specifically, we will seek to analyze the initial formation of English teachers oriented to the integration of digital medias during their practicum. We understand that the technological advances in recent decades, as well as the global processes that derive from these advances, place English teaching and the integration of medias in its practice as relevant issues today. That being said, we intend to investigate the knowledge and use of digital media that the subjects of this study - 14 undergraduates of the English Language course at UFSC - have after finishing their theoretical formation and starting their teaching practice and how this digital literacy is used during the practicum. To accomplish this goal, this research used the methodological approach of a case study, participant observation, and instruments inspired by ethnographical research combined with qualitative and quantitative approaches. We also relied on the contributions from various authors: in the area of literacy and media education we counted on the studies of Belloni, Knobel, Lankshear, Soares and others; on teacher?s training and practicum we referred to Alvarez, Pimenta and Wielewicki. Warchauer and his expertise on the CALL (Computer-Assisted Language Learning) helped us in understanding the evolution of the use of technologies and its associated methodologies in teaching English. We concluded that the practicum is the moment in which the future teachers find favorable conditions, i.e. educational support, institutional support, the physical structure of the school, student groups, among other conditions, and thus can put into practice their knowledge of teaching, in an experimental and safely way. In this context, we noted that the inclusion of media in educational activities during the practicum was considered by many of the future teachers from two perspectives: as a valuable tool in supporting the teaching of English, and also for its cultural characteristics. In the first case, the Internet and medias provided authentic and interesting materials that were relevant to the context of the students. As a cultural object, the medias were perceived by teachers as part of the digital culture in which most young generation of students were part of (cyberculture). Most students seemed to be already familiar in using and interacting in different online environments. In this sense, the integration of media in pedagogical context was aimed at bringing the culture practiced by students out of school into the classroom, with attractive and dynamic activities, in which could promote the language learning in a collaborative and enjoyable way, as well as meaningful to the learners.
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Ding, Lian Chao. "Generating Chinese calligraphy masterpiece from tablet versions." Thesis, University of Macau, 2018. http://umaclib3.umac.mo/record=b3950577.
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Tisdelle, Drew D. "A JavaScript Library for Hybrid Physical/Digital Board Games." Digital WPI, 2020. https://digitalcommons.wpi.edu/etd-theses/1374.
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Throughout the last decade handheld tablet devices have become a common part of the lives of many people. While these tablets have been widely used for games, they have been rarely used as a medium for board games in which the tablet is the game board and players interact with it using physical game tokens. The main topic of this thesis is to research past attempts at creating tablet-based board games and to use the knowledge gained from this research to develop a new, more accessible way to develop games for this medium. The Minotauros JavaScript Library, which was created to allow developers to make tablet-based board games for most tablets. The library’s functionality was tested through users playing a simple game, Roll, that implemented the library. Through thorough testing, it was found that the library is fully functional and has been made publicly available. The research behind the functionality, testing, and results of the creation of this library are detailed in this thesis.
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Nishizaki, Devin M. "The Effects of Tablets on Learning: Does Studying from a Tablet Computer Affect Student Learning Differently Across Educational Levels." Scholarship @ Claremont, 2015. http://scholarship.claremont.edu/cmc_theses/1011.
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In recent years, students and educators alike have utilized new technologies such as tablet computers as a means of enhancing the learning process. While prior research suggests that these implementations within the classroom provide a new and beneficial method of relaying and learning information, scientists have begun to explore the possible side effects that these technologies have on the learning process. Although much of the current literature suggests that learning from an electronic screen does not affect efficacy compared to learning from printed text (Bayliss et al., 2012; Dundar & Akcayir, 2012), researchers continue to explore the possible consequences that using said technologies may have in academia. The current study aims to address how tablet computers affect the process of learning differently across levels of education. It is proposed that older generations, such as college students, who did not grow up with tablets in the classroom may suffer from the effects of proactive interference when compared to younger students who have been exposed to technologies much more profoundly in their education (e.g. elementary students). If this is so, the current study also proposes a possible intervention that would help students at any educational level overcome this interference in order to integrate tablets into their studies effectively.
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Lennon, Kieran James. "Factors influencing adhesion behaviour of tablet film coats." Thesis, De Montfort University, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.250779.
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Gilliland, Charles Jordan 1979. "The paperless classroom : tablet PCs in university teaching." Thesis, Massachusetts Institute of Technology, 2004. http://hdl.handle.net/1721.1/28411.
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Thesis (M. Eng. and S.B.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2004.Includes bibliographical references (p. 302-307).
by Charles Jordan Gilliland.
M.Eng.and S.B.
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Haas, Jason M. (Jason Matthew). "SANCTUARY : asymmetric interfaces for game-based tablet learning." Thesis, Massachusetts Institute of Technology, 2013. http://hdl.handle.net/1721.1/91430.
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Thesis: S.M., Massachusetts Institute of Technology, School of Architecture and Planning, Program in Media Arts and Sciences, 2013.Cataloged from PDF version of thesis.
Includes bibliographical references (pages 109-119).
This thesis describes the production of Sanctuary, a multiplayer learning game to be played on two tablet computers. Sanctuary's principle innovation is the splitting of the user interface onto two tablets, separating player tools in separate roles and thus providing players with obtainable epistemologies. The designed intention of this interaction is to force communication and interaction and thus metacognition in players. By requiring players to express their beliefs about the game world to one another in language in order to be successful, the design of the game encourages players to formalize their intuitions and experiences. If this approach is successful, then it may be applied further to an increasing range of epistemological frames and better science education. This has the potential to build cooperative, thriving learning communities with shared experiences. The game was tested with a non-random stratified sample of high school students, suggesting new directions for the intervention, and demonstrating the value of co-design.
by Jason M. Haas.
S.M.
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Altaf, Syed Azhar. "Tablet machine instrumentation to study tablet compaction and compression of polymer-coated beads into tablets." Thesis, 1995. http://hdl.handle.net/1957/34666.
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Vitverová, Barbora. "Hodnocení relaxace tablet s theofylinem." Master's thesis, 2015. http://www.nusl.cz/ntk/nusl-337827.
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Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Technology Consultant: Doc. PharmDr. Šklubalová Zdeňka, Ph.D. Student: Barbora Vitverová Title of Thesis: Evaluation of elastic recovery of tablets containing theophylline This diploma thesis deals with evaluation of elastic recovery of tablets containing theophylline. The axial and radial elastic recovery is evaluated. Used materials are characterized in a theoretical part. It concerns microcrystalline cellulose Comprecel 102, lactose SpheroLac 100, calcii hydrogenphosphas anhydrous Di- Cafos A150, calcii hydrogenphosphas dihydrate Di-Cafos D160, magnesii stearas and theophylline. Further, compression process and its evaluation are described and also the elastic recovery of tablets after compression, its calculation and factors which can influence it. The experimental part of thesis deals with the elastic recovery of tablets. The tablets were compressed by compression strength 10 kN and the height and diameter were measured after 0, 3, 6 and 24 hours after compressing. The elastic recovery of tablets was calculated from these values. The dimensions of tablets at the maximal compression strength 10 kN were used as the initial values. From results is obvious that the highest elastic recovery is...
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Brtnová, Soňa. "Hodnocení doby rozpadu tablet obsahujících theofylin." Master's thesis, 2015. http://www.nusl.cz/ntk/nusl-331742.
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Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of: Pharmaceutical Technology Thesis supervisor: Doc. PharmDr. Zdeňka Šklubalová, Ph.D. Consultant: Mgr. Pavel Ondrejček Student: Soňa Brtnová Title of Thesis: Evaluation of disintegration time of tablets containing theophylline The influence of used fillers on energetic profile of compression, especially influence on disintegration time of tablets with theophylline as a model drug, was studied in this thesis. Four tablet fillers were studied - microcrystalline cellulose Comprecel 102, lactose SpheroLac 100, calcium hydrogen phosphate anhydrous Di- Cafos A150 and calcium hydrogen phosphate dihydrate Di-Cafos D160. Tablets contained different proportion of two fillers, theophylline as a model drug and lubricant magnesium stearate. Tablets were compressed by the same compaction force 10 kN. The force- displacement record was evaluated using the particular energies of compaction process. Parameters of compaction process were influenced mostly by Comprecel 102. According to results there is no possibility to replace Di-Cafos D160 with Di-Cafos A150 in the mixtures. It was also found that SpheroLac 100 and Di-Cafos D160 shows similar behavior. Time of disintegration of tablets is mostly dependent on the used fillers. Tablets...
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Janoutová, Hana. "Hodnocení radiální pevnosti tablet obsahujících theofylin." Master's thesis, 2015. http://www.nusl.cz/ntk/nusl-331743.
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Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Technology Consultant: Doc. PharmDr. Zdeňka Šklubalová, Ph.D. Student: Hana Janoutová Title of Thesis: Evaluation of tensile strength of tablets containing theophylline The aim of this thesis was to determine tensile strength of tablets containing theophylline. Tensile strength was studied as a function of the composition of mixtures of the used fillers and especially on their ratio. In the theoretical part, the used materials - lactose SpheroLac 100, microcrystalline cellulose Comprecel 102, dibasic calcium phosphate dihydrate Di-Cafos D160, anhydrous dibasic calcium phosphate Di-Cafos A150, theophylline and magnesium stearate are described. This work also evaluates force-displacement record, tensile strength and various factors that affect tensile strength. Parameters of force-displacement record and tensile strength of the tablets compressed with compresssion force 10 kN were evaluated in the experimental part. The measured results show that higher values of precompression energy (E1) and energy of plastic deformation (E2) were detected in mixtures A, C and E which contain Comprecel 102, and the lowest values were detected in mixtures B which contain Sphero-Lac 100 and Di-Cafos D160. Values of energy...
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Matyášová, Andrea. "Hodnocení lisovatelnosti tablet s theofylinem pomoci lisovací rovnice." Master's thesis, 2015. http://www.nusl.cz/ntk/nusl-331958.
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Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department: Department of Pharmaceutical Technology Consultant: Doc. PharmDr. Zdeňka Šklubalová, Ph.D. Student: Andrea Matyášová Title of Thesis: Evaluation of compressibility of tableting mixtures containing theophylline using a compaction equation This thesis is aimed at the evaluation and comparison of excipients used in production of tablets. The compaction process of these excipients was evaluated using the parameters of the compaction equation. The mixtures of four fillers in various ratios were evaluated. These mixtures contained also theophylline as model drug and magnesium stearate as lubricant. The used three-exponential equation was previously developed by doc. RNDr. Milan Řehula, CSc. By using this compaction equation the volume reductions, speeds of volume reductions and consumed energies were calculated and evaluated. The results of this work showed that particular used fillers have different effect on the compaction process flow. That is caused primarily by different behavior of these materials during compaction and by formation of different types of bonds. Also the need of thorough cleaning and drying of compaction aid before compaction was confirmed.
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Brunettová, Monika. "Stanovení sypnosti směsí pro přípravu tablet s theofylinem." Master's thesis, 2015. http://www.nusl.cz/ntk/nusl-334692.
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Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of: Pharmaceutical Technology Consultant: Doc. PharmDr. Šklubalová Zdeňka, Ph.D. Student: Brunettová Monika Title of Thesis: Determination of flow properties of mixtures for preparation of tablets containing theophylline The aim of this diploma thesis was to characterize the flow properties and moisture content of mixtures for preparation of tablets containing theophylline. Parameters were monitored depending mainly on the content of the fillers, that were dicalcium phosphate, microcrystalline cellulose and lactose. Twenty-five prepared mixtures with different ratios of these fillers were evaluated. Flowability was evaluated by three methods stated in Czech Pharmacopoeia 2009 - compressibility index and Hausner ratio, flow through an orifice and angle of repose. Moisture content was evaluated as a weight loss during drying. Mixtures containing dicalcium phosphate and lactose proved more appropriate in terms of flowability, their flow properties are passable. However, according to the moisture content, mixture with microcrystalline cellulose are more preferable.
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Koryťáková, Lenka. "Studium lisovacího procesu a vlastností tablet z různých typů hydrogenfosforečnanu vápenatého." Master's thesis, 2015. http://www.nusl.cz/ntk/nusl-332805.
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The thesis evaluates anhydrous and dihydrate calcium hydrogen phosphate from the view point of the tensile strength, disintegration time of tablets depending on the compression force. Two firm products - Anhydrous Emcompress® and Di-Cafos® A 60 are used as anhydrate and Emcompress® is used as dihydrate. A compression force together with lubricants (magnesium stearate, sodium stearyl fumarate) and an addition of microcrystalline cellulose (Vivapur® 102) are the influential factors. In addition to the characteristics of tablets, the energy balance of compression is also evaluated. Used compression forces were 12, 16 and 20 kN. The compression force 12 kN was used for the mixtures containing Vivapur® 102. Total energy of compression, energy for friction and energy accumulated by tablet after compression increased with compression force. The highest values were at Anhydrous Emcompress® , an addition Vivapur® 102 increased these values. There weren't more significant differences among the values of decompression energy. Plasticity decreased with the growing compression force, the highest values were at Anhydrous Emcompress® , Vivapur® 102 increased that. Tensile strength increased with compression force, Emcompress® provided the strongest tablets, Di-Cafos® A 60 provided at least strong tablets. Vivapur...
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Brokešová, Jana. "Optimalizace potahování tablet." Master's thesis, 2018. http://www.nusl.cz/ntk/nusl-380450.
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Charles University, Faculty of Pharmacy in Hradec Králové Department of: Pharmaceutical technology Supervisor: Consultant: Ing. Zdenka Mrvová Mgr. Matěj Kovář Student: Jana Brokešová Title of Thesis: Optimization of tablet coating Tablet coating represents an important procedure in pharmaceutical technology. The coating can protect an active pharmaceutical ingredient from negative environmental conditions as well as ensure the drug release at a specific time and a specific site in the organism. Generally, the main types of tablet coating are sugar and film coating. As the sugar coating has a number of disadvantages such as a time-consuming production process, the difficult process standardization, the impossibility to produce a modified release mechanism, is nowadays rarely being used in pharmaceutical companies. This work deals with the replacement of sugar coating with film coating technology for the multivitamin product Spofavit®. During the pilot batch, the commercial coating mixture Nutraficient® Food Supplement Coating, Opadry AMB was applied on two types of tablet cores: the original composition tablet cores and the modified ones with added lactose. The weight variation, hardness, friability and disintegration properties were tested. After processing the results of the pilot batch, a...
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Hávová, Šárka. "Studium lisovacího procesu a vlastností tablet s hypromelosou a monohydrátem α-laktosy." Master's thesis, 2014. http://www.nusl.cz/ntk/nusl-337309.
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Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Technology Student: Šárka Hávová Supervisor: PharmDr. Jitka Mužíková, Ph.D. Title of diploma thesis: A study of compaction process and properties of tablets with hypromellose and α-lactose monohydrate Thesis studied the co-processed dry binder RetaLac® from the aspect of his compressibility and dissolution of the active ingredient from tablets. RetaLac® contains α-lactose monohydrate and hypromellose in the identical proportion. The same parameters were tested in the corresponding physical mixtures of FlowLac® 100 with various types of hypromellose (Metolose® 100 SR, Metolose® 4000 SR, Metolose® 100 000 SR) and compared with the substance RetaLac® . Compressibility was evaluated by means of the energy profile of compression and tensile strength of tablets. Salicylic acid was used as the model active ingredient. Dissolution testing was performed using the method of the rotating basket.
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Foldyna, Edvard. "Studium lisovacího procesu a vlastností tablet z anhydrátu laktosy." Master's thesis, 2014. http://www.nusl.cz/ntk/nusl-332197.
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The thesis evaluates three types of anhydrous β-lactose combined with lubri- cants. The evaluation is made from the standpoint of compressibilty, tensile strength and ejection force, depending on the compression force used. Studied materials are Duralac H, SuperTab 21AN and Lactopress Anhydrous 250. Lubricants used in the concentration of 1% are magnesium stearate, glycerol-dibehenate and poloxamer 188. Compressibility is evaluated by the energy profile of compression. Total energy of compression increases with compression force used and de- pends on the type of anhydrous β-lactose and type of lubricant. Higher plasticity is shown by Duralac H and SuperTab 21AN. Ejection force is lowest in the case of Duralac H for all lubricants. Magnesium stearate appears to be the best lubricant for all types of anhydrous β-lactose. The effect of lubricants on the tensile strength of tablets depends on the compression force used. Highest values of disintegration time provides SuperTab 21AN, Duralac H with glycerol-dibehenate provides lowest values. 1
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Tranová, Thao. "Vliv typu plniva a rozvolňovadla na vlastnosti tablet s vysokodávkovým léčivem." Master's thesis, 2020. http://www.nusl.cz/ntk/nusl-411610.
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Charles University, Faculty of Pharmacy in Hradci Králové Department of: Pharmaceutical technology Consultant: doc. PharmDr. Jitka Mužíková, Ph.D. Student: Thao Tranová Title of Thesis: Influence of fillers' and disintegrants' type on properties of tablets with high dose drug The work engages in the study of fillers' and extragranular superdisintegrants' influence on properties of tablets with high dose drug. Two types of granulate with lactose or microcrystalline cellulose were produced in high shear granulator. Eleven tablets groups with different type and amount of superdisintegrants were prepared from the granulates. Tablets contained 2 %, 3.7 %, 5.4 % of sodium croscarmellose or 2 % and 5.4 % of crospovidone. The tested parameters of tablets were friability, hardness, disintegration time and density. Accelerated stability studies lasting 6 months at temperature of 40 řC and relative humidity 75 % were done. The tablets were evaluated after 1.5, 3 and 6 months. All tablets had adequate friability, hardness, disintegration and density at T0. Increasing concentration of superdisintegrant decreased disintegration time. Tablets containing microcrystalline cellulose and sodium croscarmellose disintegrated faster than tablets containing lactose or crospovidone. Tablets with sodium croscarmellose had...
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Luís, Ricardo Nuno Pinto Hespanhol Gomes. "Android In-Room Tablet." Master's thesis, 2012. https://repositorio-aberto.up.pt/handle/10216/66168.
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Kišková, Martina. "Adhezivní vlastnosti matricových tablet." Master's thesis, 2021. http://www.nusl.cz/ntk/nusl-445987.
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Charles University, Faculty of Pharmacy in Hradci Králové Department of Pharmaceutical Technology Name: Martina Kišková Title of diploma thesis: Adhesive properties of matrix tablets Supervisor: PharmDr. Eva Šnejdrová, Ph.D. The diploma thesis deals with the evaluation of rheological and adhesive properties of the mucin, aqueous dispersions of polymeric carriers and matrix tablets based on chitosan and sodium alginate or iota-carrageenan loaded with the salicylic acid using absolute rotational rheometer. The theoretical part deals with the characterization and classification of matrix tablets, polymeric carriers (sodium alginate, chitosan and carrageenan) and with the principles of evaluation of rotational, adhesive and oscillational tests performed in the experimental part. The mucin from porcine gastric used as a model substrate for adhesion tests behaves as a viscoelastic solid and its adhesive strength decreases with increasing hydration. Significantly higher adhesive strength was found for chitosan at pH 1.2 and sodium alginate at pH 6.8 compared to the adhesive strength of iota-carrageenan. In terms of viscoelastic properties, chitosan and sodium alginate are viscoelastic fluids, but iota-carrageenan is a viscoelastic solid. Iota-carrageenan forms the stiffest gel after hydration at pH 6.8...
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Luís, Ricardo Nuno Pinto Hespanhol Gomes. "Android In-Room Tablet." Dissertação, 2012. https://repositorio-aberto.up.pt/handle/10216/66168.
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Vawda, Naseem. "An evaluation of directly compressible tablet bases on the performance of ibuprofen tablets." Thesis, 2001. https://hdl.handle.net/10539/24543.
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A research report submitted to the Faculty of Health Sciences, University of the Witwatersrand , in partial fulfilment of the requirements for the degree of Master of Science in Medicine (Pharmaceutical affairs)Ibuprofen is a phenylpropionic acid derivative, which has analgesic, antiinflammatory and antipyretic actions. It is used in the management of mild to moderate pain, inflammatory conditions, peri-articular disorders, musculoskeletal disorders and joint disorders. Tablets, like ibuprofen, can be manufactured by three different processes viz. wet granulation, dry granulation and direct compression. With direct compression, the directly compressible base, along with the active ingredient (ibuprofen) and other suitable excipients, can be compressed directly.
IT2018
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Louženská, Markéta. "Studium lisovacího procesu a vlastností tablet s mikrokrystalickou celulosou a koloidním oxidem křemičitým." Master's thesis, 2015. http://www.nusl.cz/ntk/nusl-332798.
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The thesis deals with the comparison of compressibility and properties of tablets containing silicified microcrystalline cellulose and physical mixtures of microcrystalline cellulose with different types of colloidal silicon dioxide. The used excipients were silicified microcrystalline cellulose Prosolv® SMCC 90, microcrystalline cellulose Avicel® PH-102 and colloidal silicon dioxide Aerosil® 200 and 255. Tablets were compressed at three compression forces 2.5, 3 and 3.5 kN. The energy profile of compression, the tensile strength of tablets and the disintegration time of tablets were evaluated. The effect of 1 % magnesium stearate on these parameters under various mixing conditions and its homogenity in the tablet were evaluated. Total energy of compression increased with the growing compression force, it was the highest at Prosolv® SMCC 90. Plasticity decreased with compression force, mixtures of Avicel® PH-102 with both types of Aerosil showed its the highest values. These mixtures provided tablets with lower strength than Avicel® PH-102 and Prosolv® SMCC 90. Disintegration time of tablets increased with the growing compression force and it was longer in the case of tablets from Prosolv® SMCC 90 and Avicel® PH-102. The addition of magnesium stearate decreased tensile strength of tablets most in...
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Vávrová, Kateřina. "Hodnocení disoluce tablet obsahujících theofylin a směsi dvou typů hydrogenfosforečnanu vápenatého a mikrokrystalické celulosy." Master's thesis, 2017. http://www.nusl.cz/ntk/nusl-367733.
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Charles University in Prague, Faculty of Pharmacy in Hradci Králové Department of Pharmaceutical technology Consultant: PharmDr. Pavel Ondrejček, Ph.D. Student: Kateřina Vávrová Title of Thesis: Dissolution testing of tablets containing theophylline and mixtures of two types of calcium hydrogen phosphates and microcrystalline cellulose The aim of this thesis was the dissolution testing of tablets containing theophylline, the mixture of two dicalcium phosphate types and microcrystalline cellulose. The influence of tablet composition on the dissolution profiles was evaluated. The tablets were prepared from the mixtures containing microcrystalline cellulose, dicalcium phosphate anhydrous and dihydrate. These substances were used as fillers. Prepared mixtures contained theophylline as a model active ingredient and magnesium stearate as lubricant. Afterwards, the dissolution tests were done. For these tests, the basket method was utilized. As a dissolution medium the 0,1M hydrochloric acid solution was used. From the results of this experiment we concluded that we can influence the total amount of released theophylline and the speed of its release by the different ratio of microcrystalline cellulose and one of dicalcium phosphate types. The fastest theophylline dissolution was in tablets with high...
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Tumová, Šárka. "Studium lisovatelnosti a vlastností tablet ze silicifikované mikrokrystalické celulosy pro tablety dispergovatelné v ústech." Master's thesis, 2016. http://www.nusl.cz/ntk/nusl-346946.
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The thesis deals with the study of the compressibility and properties of tablets from Prosolv® ODT G2. This substance was tested in combination with two lubricants - magnesium stearate and sodium stearyl fumarate, for this purpose two concentrations were used 0.5 % and 1 %. Combination with model drugs was also included. Prosolv ® ODT G2 was also compared with Prosolv® SMCC 50 in the studied properties. The compressibility was evaluated by energy profile of compression process. Tensile strength and disintegration time were tested properties of tablets. The total energy values of tableting materials with Prosolv® ODT G2 were not enough affected by lubricants, though acetylsalicylic acid increased total energy. In the case of Prosolv® SMCC 50 the values of total energy were increased. Plasticity decreased in the case of Prosolv® ODT G2 under the influence of lubricants and drugs. Plasticity values for Prosolv® SMCC 50 were higher and more balanced. Lubricants in the mixtures with Prosolv® ODT G2 caused higher strength, however ascorbic acid decreased tensile strength of tablets. Tablets from the Prosolv® SMCC 50 mixture were significantly stronger, but lubricants decreased tensile strength of tablets. The disintegration time of tablets with Prosolv® ODT G2 was very short. It was proved that...
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Hofmanová, Markéta. "Měření stresové relaxace směsí mikrokrystalické celulosy a hydrogenfosforečnanu vápenatého určených k přípravě tablet s theofylinem." Master's thesis, 2015. http://www.nusl.cz/ntk/nusl-335187.
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Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of: Pharmaceutical technology Consultant: Doc. PharmDr. Sklubalova Zdenka, Ph.D. Student: Marketa Hofmanova Title of Thesis: Measurement of stress relaxation of mixtures of microcrystalline cellulose and calcium hydrogen phosphate intended for the preparation of tablets with theophylline The powder mixtures with theophylline were studied from the aspect of viscoelastic properties of used materials and tablets tensile strength. In the theoretical part the thesis concerned with description of materials which were used in the mixtures. They are: Microcrystalline cellulose Comprecel 102, calcium hydrogen phosphate anhydrate Di-Cafos A150, calcium hydrogen phosphate dihydrate Di-Cafos D160 and lactose SpheroLac 100. The thesis also deals with the stress relaxation test. The stress relaxation test, its evaluation by several methods and its use in the pharmacy and in different fields are described. The experimental part deals with viscoelastic characteristics of the mixtures. These characteristics were evaluated by stress relaxation test with maximal compression force 10 kN and dwell time 180 s. Also the tensile strength was evaluated. The highest values of parameters of elasticity A1-3 and plasticity P1-3 were measured in...