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Journal articles on the topic 'Tablets : Drugs'

Author: Grafiati

Published: 4 June 2021

Last updated: 12 February 2022

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1

Nolly, Robert J., Patrick Rodrigues, and Laura Thoma. "Weight Variability of Scored and Unscored Psychotropic Drug Tablets Split by a Uniquely Designed Tablet Splitting Device." Hospital Pharmacy 40, no. 4 (2005): 321–25. http://dx.doi.org/10.1177/001857870504000406.

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Tablets of three psychotropic drugs were split using a uniquely designed tablet splitting device, the Tru-Cut Multi-Tablet Cutter, and evaluated for weight variation utilizing criteria based on the United States Pharmacopeia (USP) <27> Uniformity of Dosage Units Content Uniformity Criteria. Whole tablets of Risperdal 2 mg and 4 mg, Paxil 20 mg and 40 mg, and Zoloft 100 mg were split by a device that positioned tablets in tablet specific disposable trays for splitting. Each half tablet weight was recorded utilizing a digital electronic balance. Weight variability was determined by compari

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2

Cardoso-Palacios, Carlos, and Ingela Lanekoff. "Direct Analysis of Pharmaceutical Drugs Using Nano-DESI MS." Journal of Analytical Methods in Chemistry 2016 (2016): 1–6. http://dx.doi.org/10.1155/2016/3591908.

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Counterfeit pharmaceutical drugs imply an increasing threat to the global public health. It is necessary to have systems to control the products that reach the market and to detect falsified medicines. In this work, molecules in several pharmaceutical tablets were directly analyzed using nanospray desorption electrospray ionization mass spectrometry (nano-DESI MS). Nano-DESI is an ambient surface sampling technique which enables sampling of molecules directly from the surface of the tablets without any sample pretreatment. Both the active pharmaceutical ingredients (APIs) and some excipients w

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3

Swetanshu, ,., and Vijay Sharma. "Formulation, Optimization and Evaluation of Bilayer Tablet of Antihypertensive Drug." Journal of Drug Delivery and Therapeutics 9, no. 4 (2019): 704–8. http://dx.doi.org/10.22270/jddt.v9i4.3098.

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Hypertension or high blood pressure occurs when the high cardiac output exerts pressure on the arterial wall as the blood flow increases. Bi-layer tablets are prepared with one layer of drug for immediate release while second layer designed to release drug later, either as second dose or in an extended release manner. Bi-layered tablet is suitable for sequential release of two drugs in combination, separate two incompatible substances, and also for sustained release tablet in which one layer is immediate release as initial dose and second layer is maintenance dose. Bilayer tablet is suitable f

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Latifiana, Umi, Deny Budi Legowo, Erna Fitriany, Andri Priyoherianto, and Muhammad Novianto Ainul Huri. "Uji Mutu Fisik Metoklopramid HCl Tablet Chewable dengan Variasi Jenis Pengisi sebagai Diluent menggunakan Metode Granulasi Basah." Indonesian Journal of Pharmaceutical Education 1, no. 2 (2021): 76–85. http://dx.doi.org/10.37311/ijpe.v1i2.10638.

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Metoclopramide HCl are used to reduce vomiting and nausea. The availability on the market in the form of tablet, syrup and injection. Patient tend to prefer take drugs by oral use because it was easier. Chewable tablet is the new product as the alternative ways to treatment children and adult patient who had difficulity problem of swallowing drugs. Objectives: This research aims to formulate the chewable metoclopramide HCl tablets using diluent variations to get a better physical quality test. Chewable tablets of metoclopramide HCl are made using diluent variations, they are mannitol, sucrose,

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Veronin, Michael A., Eunah Lee, and E. Neil Lewis. "“Insight” into Drug Quality: Comparison of Simvastatin Tablets from the US and Canada Obtained via the Internet." Annals of Pharmacotherapy 41, no. 7-8 (2007): 1111–15. http://dx.doi.org/10.1345/aph.1h680.

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Background: Recently, there has been much debate in the US concerning drug importation from Canadian Internet pharmacies. The Food and Drug Administration and US drug manufacturers assert that drugs obtained from international markets via the Internet present a health risk to consumers from substandard products. The public's perception is that drugs from Canada are as safe as those from the US. Objective: To determine whether simvastatin tablets obtained via the Internet from Canadian generic manufacturers are comparable in blend uniformity, a major attribute of tablet quality, with the US inn

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Triastutik, Irsalina, Lusia Oktora Ruma Kumala Sari, and Lina Winarti. "Optimasi Hydroxypropyl Methylcellulose dan Chitosan pada Tablet Floating-Mucoadhesive Diltiazem Hidroklorida Menggunakan Desain Faktorial." Pustaka Kesehatan 8, no. 3 (2020): 159. http://dx.doi.org/10.19184/pk.v8i3.11419.

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Diltiazem HCl is one of the drugs used for hypertension treatment. It requires frequent dosing, which is why diltiazem HCl needs to be formulated into preparations using a controlled release drug delivery system. The combination of floating and the mucoadhesive system is expected to increase the stomach's retention of the dosage form. This study aimed to determine the optimum composition of hydroxypropyl methylcellulose (HPMC K100M) and chitosan for floating mucoadhesive diltiazem HCl tablet. Tablets that have been prepared were evaluated for the tablet's physical characterization, powder flow

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Carnwath, T. "Temazepam tablets as drugs of misuse." BMJ 307, no. 6900 (1993): 385–86. http://dx.doi.org/10.1136/bmj.307.6900.385-c.

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Puspadina, Valiandri, Deny Budi Legowo, Erna Fitriany, Andri Priyoherianto, and Winda Damayanti. "EFFECT OF VARIATION OF LUBRICANT CONCENTRATION (MAGNESIUM STEARATE) ON THE PHYSICAL QUALITY OF METOCLOPRAMID HCl TABLETS WITH DIRECT PRINTING METHOD." Indonesian Journal of Pharmaceutical Education 1, no. 2 (2021): 67–75. http://dx.doi.org/10.37311/ijpe.v1i2.10567.

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Metoclopramide HCl is used to relieve nausea and vomiting. Market availability in the form of tablets, syrup and injection. The most preferred drug use by patients is oral medication because of its ease of use. Chewable tablets are a new product as an alternative for treatment in pediatric and adult patients who have difficulty swallowing drugs. This study aims to formulate the chewable tablet preparations of metoclopramide HCl using variations in lubricant concentrations. The variations of magnesium stearate with concentrations of 1%, 2%, and 3% using the direct printing method made to obtain

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9

Coutinho, Ana Luisa, Asmita Adhikari, and James Polli. "10122 Development of an In Vitro in Vivo Correlation of Itraconazole Spray-Dried Dispersion Tablets." Journal of Clinical and Translational Science 5, s1 (2021): 96–97. http://dx.doi.org/10.1017/cts.2021.649.

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ABSTRACT IMPACT: As the number of poorly water-soluble drugs in development increases, our research will expand on the science behind improving drug solubility and absorption and ensuring that promising poorly-water solubility drugs do not fail drug development. OBJECTIVES/GOALS: Spray-dried dispersion (SDD) tablet formulation is an approach to increase oral drug solubility and absorption. Methods to predict SDD performance in humans are poorly developed. We aim to develop an in vivo in vitro correlation (IVIVC) between in vitro dissolution and in vivo absorption of itraconazole SDD tablets. M

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Jacques, Emmanuel Reginald, and Paschalis Alexandridis. "Tablet Scoring: Current Practice, Fundamentals, and Knowledge Gaps." Applied Sciences 9, no. 15 (2019): 3066. http://dx.doi.org/10.3390/app9153066.

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Oral solid dosage formulations and/or tablets have remained the preferred route of administration by both patients and health care practitioners. Oral tablets are easy to administer, they are non-invasive and cause less risk adversity. Because of the lack of commercially available tablet dose options, tablets are being split or partitioned by users. Tablet scoring refers to the breakage of a tablet to attain a desired efficacy dose and is an emerging concept in the pharmaceutical industry. The primary reason for the tablet scoring practice is to adjust the dose: dose tapering or dose titrating

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Aabed, Wafa’ J., Asma H. Radwan, Abdel Naser Zaid, and Naser Y. Shraim. "Extemporaneous Compounding and Physiological Modeling of Amlodipine/Valsartan Suspension." International Journal of Hypertension 2021 (March 12, 2021): 1–10. http://dx.doi.org/10.1155/2021/6695744.

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Background and Objectives. In case of absent liquid dosage form, crushing a tablet or dispersing a capsule would be the most convenient option for using these drugs in patients with dysphagia difficulties. The aims of the study were to prepare an extemporaneous suspension of amlodipine and valsartan from the available commercial tablets and to evaluate the stability and dissolution properties of the compounded suspension. Method. Amlodipine/valsartan extemporaneous suspension was prepared from available commercial tablets such as Valzadepine®. The dissolution profiles for the extemporaneous pr

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Masih, Ashish, Amar Kumar, Shivam Singh, and Ajay Kumar Tiwari. "FAST DISSOLVING TABLETS: A REVIEW." International Journal of Current Pharmaceutical Research 9, no. 2 (2017): 8. http://dx.doi.org/10.22159/ijcpr.2017v9i2.17382.

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Fast dissolving tablets emerge as one of the popular and widely accepted dosage forms, especially for pediatric patients because of incomplete development of the muscular and nervous system and a case of geriatric patients suffering from Parkinson’s disorder or hand tremors. Few solid dosage forms like capsules and tablets are present days facing the problems like difficulty in swallowing (dysphagia), resulting in many incidences of non-compliance and making the therapy ineffective. Oral dosage form and oral route are the most preferred route of administration for various drugs have limitation

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13

Lordi, Nicholas G., and Alberto M. Cuitino. "Compaction of Pharmaceuticals." MRS Bulletin 22, no. 12 (1997): 34–37. http://dx.doi.org/10.1557/s0883769400034722.

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It has been estimated that more than 80% of all medication doses are administered as tablets—that is, in unit dosage forms prepared by compacting powders in dies. For drugs with acceptable oral-absorption profiles, the compacted tablet is the first choice as a delivery system in drug development. Modern tablets range in size from 25 milligrams (veterinary implants) to several grams (veterinary “boluses”). The most common tablet shape is the double convex-faced disk. Shapes range from capsule to triangular forms, in many instances with bisects embossed or debossed with identification codes and

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14

Musumeci, Daniele, Chunhua Hu, and Michael Ward. "Fighting Counterfeit Drugs Using Micro-X-Ray Diffraction." Acta Crystallographica Section A Foundations and Advances 70, a1 (2014): C1134. http://dx.doi.org/10.1107/s2053273314088652.

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A new protocol using micro-X-ray diffraction is developed to certify the authenticity of drug tablets, and therefore to prevent, deter, or detect counterfeit medicinal products. The method uses X-ray to map hidden patterns printed under the tablet coating and on packages. The patterns such as barcodes and logos are made of compounds approvoved by the Food and Drug Administration. The method is nondestructive, automated and user-friendly. The protocol relies on verification of phase, composition, and pattern readout in a single measurement, which reduces the risk of circumvention.

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15

Bhattacharya, Suhasis, Tanmay Mohanta, Sujit Das, and Rumpa Basak. "Orodispersible Tablet in Treatment of Migraine: Opportunities, Challenges and Recent Advancements." Journal of Drug Delivery and Therapeutics 11, no. 4 (2021): 149–56. http://dx.doi.org/10.22270/jddt.v11i4.4878.

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The most comfortable and choicely path of drug administration is oral route. Orodispersible tablets bring a revolution among all routes of drug administration as well as oral route of drug administration also. Orodispersible tablets are unit dosage form but it has unique characteristics. It disintegrates in the mouth within a minute for the presence of saliva where the presence of super disintegrates in the preparation. Especially, old and child have no chance to swallow as a result it is very acceptable for them. Migraine is a very well-known irritating condition for adult and female. Migrain

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16

Shah, Suchi M., Anil P. Singh, and Parth K. Vachhani. "Drug price control order: the impact on pharmacoeconomics." International Journal of Basic & Clinical Pharmacology 8, no. 10 (2019): 2220. http://dx.doi.org/10.18203/2319-2003.ijbcp20194259.

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Background: The objective of the present study was to analyze the prices of metformin, losartan, atorvastatin, paracetamol and aspirin for the doses which are included in the list of Drug Price Control Order (DPCO) 2013.Methods: Current index medical specialties India, 37th year, April-July 2015 issue was used for analysis. The retail prices of the drugs in INR were tabulated in Microsoft Office Excel 2013. The prices of the above listed drugs were compared with prices of DPCO 2013 for the same doses of drugs. The analysis of drugs costing more than the prices listed in the DPCO with the margi

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17

Kim, Ki Hyun, Minju Jun, and Mi-Kyung Lee. "Bioavailability of the Common Cold Medicines in Jellies for Oral Administration." Pharmaceutics 12, no. 11 (2020): 1073. http://dx.doi.org/10.3390/pharmaceutics12111073.

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Jellies for oral administration have been suggested as alternative dosage forms to conventional tablets for improved palatability and compliances for pediatric and geriatric patients. To evaluate the effect of jelly formulation on the bioavailability of cold medicines, two types of jellies were prepared for a fixed-dose combination of acetaminophen (AAP), chlorpheniramine maleate (CPM), dextromethorphan hydrobromide (DMH), and dl-methylephedrine hydrochloride (MEH). Jelly-S and Jelly-H were fabricated using carrageenan and locust bean gum in the absence and presence of xanthan gum, respectivel

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18

Blatnik, Sandra Urek, Rok Dreu, and Stanko Srčič. "Influence of pH modifiers on the dissolution and stability of hydrochlorothiazide in the bi- and three-layer tablets." Acta Pharmaceutica 65, no. 4 (2015): 383–97. http://dx.doi.org/10.1515/acph-2015-0031.

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Abstract During the past few years, the studies of bi- and multi-layered tablets increased due to the consumption of several different drugs per day by a patient and requests for appropriate patient compliance. The demographic shift toward older population increases the use of combination therapy as polypharmacy. Hydrochlorothiazide (HCTZ), as a model drug, is most commonly used in the treatment of hypertension, congestive heart failure and as a diuretic. The aim of the present study is to investigate the effect of the local environment on dissolution and stability behaviour of HCTZ in fixed m

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Mondal, Nita. "THE ROLE OF MATRIX TABLET IN DRUG DELIVERY SYSTEM." International Journal of Applied Pharmaceutics 10, no. 1 (2018): 1. http://dx.doi.org/10.22159//ijap.2018v10i1.21935.

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Matrix tablet is an important tool for controlled and sustained release dosage forms. The oral route remains the most common route for the administration of drugs. Tablets offer the lowest cost approach to sustained and controlled release dosage forms. The hydrophilic polymer matrix is widely used in this dosage form. The use of different polymers in controlling the release of drugs has become the most important tool in the formulation of matrix tablets. The drug releases by both dissolution-controlled as well as diffusion-controlled mechanisms from the matrix. The development of oral controll

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20

Reddy M., Sunitha, and Lavanya Muppa. "A REVIEW OF CHALLENGES AND POSSIBILITIES OF BILAYER TABLET TECHNOLOGY." International Journal of Advanced Research 9, no. 08 (2021): 676–81. http://dx.doi.org/10.21474/ijar01/13315.

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Bilayer tablet making process involves certain challenges as well as advantages. Bilayer tablets are the prescriptions which comprise of two same or various medications consolidated in a solitary portion for viable treatment of the illness. Persistent consistence and cost measure are two significant boundaries in treatments. Bilayer tablets manage these focuses adequately. To deliver a decent quality bi-layer tablet, the apparatus should be built according to GMP. Different hardware are accessible to beat normal bi-layer issues, for example, layer detachment, lacking hardness, weight control,

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RADA, SANTOSH KUMAR, and T. Naga Satya Yagnesh. "OPTIMISATION OF STARCH OXALATE AS A NOVEL SUPERDISINTEGRANT IN FAST DISSOLVING SYSTEMS OF POORLY SOLUBLE DRUGS." Journal of Drug Delivery and Therapeutics 9, no. 1-s (2019): 185–95. http://dx.doi.org/10.22270/jddt.v9i1-s.2385.

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Objective: To enhance the solubility of poorly soluble drugs by using 23 factorial design in the formulation of fast dissolving tablets by employing starch oxalate as a superdisintegrant. Methods: Starch oxalate was synthesized by gelatinization process. The physical and micromeritic properties were performed to evaluate the synthesized starch oxalate. By using 23 factorial design, atenolol fast dissolving tablet was prepared by employing starch oxalate as a superdisintegrant in different proportions in each case by direct compression method. In the evaluation of fast dissolving tablets

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22

Peters, I. O. M., A. Willemsen, J. J. de Bruyne, and R. C. Nap. "Aspirin Medication in Dogs." Veterinary and Comparative Orthopaedics and Traumatology 4, no. 03 (1991): 95–99. http://dx.doi.org/10.1055/s-0038-1633260.

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SummaryAspirin (acetylsalicylic acid; ASA) is widely used in both human and veterinary medicine. Therapeutic plasma salicylate concentrations (PSCs) can be reached using enteric-coated ASA tablets, but a delay in the initial rise and large fluctuations in the PSCs have been reported. From experiments described previously, the authors concluded that the large type enteric-coated ASA tablets were not suitable for use in beagle dogs.In the first experiment described here, these large type tablets were administered to large mongrel dogs. Although the mean PSC reached therapeutic levels after 44 h,

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S., Aher Smita, Saudagar R. B., and Shinde Mayuri S. "REVIEW: FAST DISSOLVING TABLET." International Journal of Current Pharmaceutical Research 10, no. 2 (2018): 5. http://dx.doi.org/10.22159/ijcpr.2018v10i2.25876.

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Fast dissolving tablets is one of the most widely accepted dosage forms and also most popular dosage form, especially for pediatric patients because of incomplete development of the muscular and nervous system and a case of geriatric patients suffering from Parkinson’s disorder or hand tremors. Some solid dosage forms like tablets and capsules are present days facing the problems like difficulty in swallowing (dysphagia), resulting in many incidences of non-compliance and making the therapy ineffective. Oral dosage form and oral route are the most preferred route of administration for various

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Schykovskiy, O. E., and Т. V. Кrutskikh. "Pharmaceutical development with commercialization of generic drugs with poor soluble substance – tablets of drug nimodipine." Farmatsevtychnyi zhurnal, no. 3-4 (August 14, 2018): 60–70. http://dx.doi.org/10.32352/0367-3057.3-4.17.07.

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The pharmaceutical development of solid dosage forms which containing a poor soluble substance deserves special attention, because a composition and a technology of production such drugs directly effects on release the active pharmaceutical ingredient in the human body and, as a consequence, on pharmacological effectiveness of this drug. The search of therapeutically effective, economically viable and industrially reproducible technology for the production of such drugs is very important for the pharmaceutical industry. The purpose of our work was the pharmaceutical development of the ge

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Katsiotis, Christos S., Michelle Åhlén, Maria Strømme, and Ken Welch. "3D-Printed Mesoporous Carrier System for Delivery of Poorly Soluble Drugs." Pharmaceutics 13, no. 7 (2021): 1096. http://dx.doi.org/10.3390/pharmaceutics13071096.

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Fused deposition modelling (FDM) is the most extensively employed 3D-printing technique used in pharmaceutical applications, and offers fast and facile formulation development of personalized dosage forms. In the present study, mesoporous materials were incorporated into a thermoplastic filament produced via hot-melt extrusion and used to produce oral dosage forms via FDM. Mesoporous materials are known to be highly effective for the amorphization and stabilization of poorly soluble drugs, and were therefore studied in order to determine their ability to enhance the drug-release properties in

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Kenyon, Allen S., Paul E. Flinn, and Thomas P. Layloff. "Rapid Screening of Pharmaceuticals by Thin-Layer Chromatography: Analysis of Essential Drugs by Visual Methods." Journal of AOAC INTERNATIONAL 78, no. 1 (1995): 41–49. http://dx.doi.org/10.1093/jaoac/78.1.41.

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Abstract A method for rapidly screening pharmaceuticals by thin-layer chromatography has been designed for use in areas with limited resources and by operators with limited training. An apparatus for performing the analysis in a plastic bag under equilibrium conditions was designed. Results can be reproduced by different operators and in different locations. The analysis can be performed without electricity or in a remote area, away from a laboratory. It is especially suited for field use in developing countries. The method is low cost, maintenance-free, fast, and reliable; it also uses limite

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Rao, Y. Madhusudan, N. Doodipala, C. R. Palem, and S. Reddy. "Pharmaceutical Development and Clinical Pharmacokinetic Evaluation of Gastroretentive Floating Matrix Tablets of Levofloxacin." International Journal of Pharmaceutical Sciences and Nanotechnology 4, no. 3 (2011): 1463–70. http://dx.doi.org/10.37285/ijpsn.2011.4.3.4.

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The most common approach for achieving sustained drug release is by the use of hydrophilic polymeric excipients directly compressed with active ingredients into tablets. Hydrophilic polymers swell in the presence of water to form hydrogel structures from which drugs are released by slow diffusion. The purpose of this study was to prepare a floating drug delivery system of levofloxacin, a fluoroquinolone antibiotic. Levofloxacin is highly soluble in acidic media and precipitates in alkaline media, thereby losing its solubility. We designed a gastroretentive system of levofloxacin to enhance bio

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Domanina, A. M., M. V. Chernikov, I. P. Remezova, E. F. Stepanova, A. M. Shevchenko та A. V. Morozov. "Preparation of 2-phenyl-9-diethylaminoethylimidazo[1,2-α]benzimidazole dinitrate tablets and development of quality control methods". Drug development & registration 10, № 2 (2021): 62–67. http://dx.doi.org/10.33380/2305-2066-2021-10-2-62-67.

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Introduction. Currently, for the treatment of gastric ulcer, drugs with a combined effect are used. To eliminate possible side effects of the drugs used, the search for new molecules to create more effective and safe histamine H2 receptors continues. As a possible solution to these problems, we investigated the substance dinitrate of 2-phenyl-9-diethylaminoethylimidazo[1,2-α]benzimidazole (DFDB).Aim. The aim of this study was to obtain 2-phenyl-9-diethylaminoethylimidazo[1,2-α]benzimidazole dinitrate tablets and develop methods for quality control.Materials and methods. The object of study was

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Sonare, Makrand A., and Manoj Kumar Samantaray. "Pharmaceutical evaluation of Haridra Khanda tablet." Journal of Ayurveda and Integrated Medical Sciences (JAIMS) 5, no. 05 (2020): 175–78. http://dx.doi.org/10.21760/jaims.5.5.24.

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Haridra Khanda is unique classical formulation indicated in Udarda, Shitapitta, Kotha. (Urticarial rashes) Khanda or Granules are a comparatively unusual means of administering drugs that possess an unpleasant taste. Haridra Khanda is classical Ayurvedic medicine and available market. Keeping the issue of palatability and invention of patient friendly dosage form in mind, the efforts was made for preparation of tablet out of classical Ayurvedic formulation - Haridra Khanda. The preparation of Haridra Khanda granules were made by standard operative procedure.Binding agents were added to Haridra

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Kumar Pal, Manish, and Ganesh Deshmukh. "DESIGN AND CHARACTERIZATION OF CHLORZOXAZONE FLOATING BIOADHESIVE DRUG DELIVERY SYSTEM." Asian Journal of Pharmaceutical and Clinical Research 11, no. 11 (2018): 222. http://dx.doi.org/10.22159/ajpcr.2018.v11i11.27693.

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Objective: The objective of the work is to formulate chlorzoxazone floating bioadhesive tablets which will significantly improve the bioavailability of drugs under the condition of prolonged use of drugs and reduce the total dosage of administered drug and reduce the side effect.Methods: Floating bioadhesive tablet was prepared by direct compression of polymer such as HPMCK4M and Carbopol934p in combination.Result: After analysis of different evaluation parameter and drug release, F9 batch was selected as promising formulation for delivery of chlorzoxazone floating bioadhesive tablets with 92.

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Thoma, K., and T. Zimmer. "Retardation of weakly basic drugs with diffusion tablets." International Journal of Pharmaceutics 58, no. 3 (1990): 197–202. http://dx.doi.org/10.1016/0378-5173(90)90195-a.

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Signori, Alessio, Francesco Saccà, Roberta Lanzillo, et al. "Cladribine vs other drugs in MS." Neurology - Neuroimmunology Neuroinflammation 7, no. 6 (2020): e878. http://dx.doi.org/10.1212/nxi.0000000000000878.

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ObjectiveCladribine tablets were tested against placebo in randomized controlled trials (RCTs). In this study, the effectiveness of cladribine vs other approved drugs in patients with relapsing-remitting MS (RRMS) was compared by matching RCT to observational data.MethodsData from the pivotal trial assessing cladribine tablets vs placebo (CLARITY) were propensity score matched to data from the Italian multicenter database i-MuST. This database included 3,150 patients diagnosed between 2010 and 2018 at 24 Italian MS centers who started a disease-modifying drug. The annualized relapse rate (ARR)

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CHOURASIYA, ANJALI, NARENDRA GEHALOT, and SURESH CHANDRA MAHAJAN. "A REVIEW ON AN EMERGIN TREND BILAYER FLOATING DRUG DELIVERY SYSTEM." Current Research in Pharmaceutical Sciences 11, no. 2 (2021): 44–49. http://dx.doi.org/10.24092/crps.2021.110201.

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NDDS is advanced drug delivery system which improves drug potency, control drug release to give a sustained therapeutic effect, provide greater safety, finally it is to target a drug specifically to a desired tissue. Novel drug delivery system have been developed to overcome the limitation of conventional drug delivery systems, such as of gastric retention by decreasing fluctuations in the concentration of the drug in blood,resulting in the reduction in unwanted toxicity and poor efficiency. As compared to traditional dosage forms bilayer tablets are more efficient for sequential release of tw

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Pundir, Sarika, and Ashutosh Badola. "Formulation and Evaluation of Atenolol and Indapamide SR Matrix Tablets for Treatment of Hypertension." International Journal of Pharmaceutical Sciences and Nanotechnology 7, no. 2 (2014): 2450–58. http://dx.doi.org/10.37285/ijpsn.2014.7.2.7.

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In the present study we have formulated (F1 to F6) matrix tablets of atenolol and indapamide for the management of hypertension. As in simultaneous estimation of these drugs it was found that a confined release can be formulated. In the formulation of SR matrix tablet by using different concentration of delayed release agent DCP and pregelatinized starch as disintegrant we prepared tablets by wet granulation method. For sustained release action HPMC polymers were used for film coating. Preformulation studies were performed prior to compression. The compressed SR matrix tablets were evaluated f

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Kumar, Vishal, Attish Bhardwaj, Navdeep Singh, Kamya Goyal, and Shammy Jindal. "A Review on Tablet Dosage Form: Recent Advancements with Special Emphasis on Rapid Disintegrating Tablet." Asian Journal of Research in Pharmaceutical Sciences 11, no. 3 (2021): 237–46. http://dx.doi.org/10.52711/2231-5659.2021.00038.

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Tablets are the most commonly prescribed dosage form as offer a convenient form of drug administration provides dosage uniformity from tablet to tablet, stable over extended and diverse storage conditions, can be produced on high-speed compression, labelling, and packaging equipment. Advancements in technology and modification in standard compressed tablet are to achieve better acceptability as well as bioavailability. Various types of newer and more efficient tablets are developed to create a delivery system that is relatively simple to administration. In one sense osmotic pump systems are an

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Pingale, Prashant L. "FORMULATION, CHARACTERIZATION AND IN-VITRO DISSOLUTION STUDIES OF METADOXINE TABLETS PREPARED BY VARIOUS GRANULATION METHODS." Journal of Medical pharmaceutical and allied sciences 10, no. 2 (2021): 2712–19. http://dx.doi.org/10.22270/jmpas.v10i2.1066.

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Pharmaceutical tablets are robust, flat, or biconvex dishes, according to the Indian Pharmacopoeia. Depending on a range of medicinal substances, they vary in shape and differ greatly in size and weight. In the era of increasing health awareness and strict standards set by regulatory authorities such as the US FDA, WHO, and globalization, it has become mandatory for the producer to launch a product cost-effectively. In the tablet dosage form, two classes of drugs are administered orally. Narrow extensions of the parietal peritoneum that suspend the diaphragm's liver are the right and left coro

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Stamate, Monica Cretan, Carmen Gafitanu, Ciprian Stamate та Eliza Gafitanu. "The Characterization of Ketoprofen-Hydroxypropyl–β-Cyclodextrin Complex with Modified Drugs Release Properties". Solid State Phenomena 188 (травень 2012): 70–75. http://dx.doi.org/10.4028/www.scientific.net/ssp.188.70.

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Since, anti-inflamatory drugs have a high demand due to increased incidence of pain associated with different pathology; the objectives of this paper are the synthesis, the physicochemical characterization and analysis of the tribological properties for the ketoprofen-cyclodextrin complexes. The analysis of solubility for these complexes was carried out using MathCAD software. Tribological factors were evaluated by the wear resistance of cylindrical tablets containing ketoprofen-cyclodextrin complex, methocel and magnesium stearate. The tablets with ketoprofen-cyclodextrin complexes provide go

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Nair, Manju K., and Neha M. S. "Cost variation analysis of antihypertensive drugs acting through renin angiotensin aldosterone axis modulation." International Journal of Basic & Clinical Pharmacology 6, no. 5 (2017): 1085. http://dx.doi.org/10.18203/2319-2003.ijbcp20171500.

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Background: Several brands of antihypertensive drugs are available in the Indian market with huge price variations. This study was undertaken to find out the percentage cost variation and cost ratio of antihypertensive drugs acting through renin angiotensin aldosterone axis modulation.Methods: Costs of different brands of renin angiotensin aldosterone axis modulatory drugs with antihypertensive action for the same dosage form and strength were found out using current index of medical specialties-134, July-October 2016. The maximum and minimum price of different brands of each drug was noted. D

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Saini, Seema, and Rajeev Garg. "Design expert assisted mathematical optimization of solubility and study of fast disintegrating tablets of Lercanidipine Hydrochloride." Journal of Drug Delivery and Therapeutics 9, no. 1-s (2019): 172–80. http://dx.doi.org/10.22270/jddt.v9i1-s.2406.

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90% of drugs being researched today, posses poor solubility setback which inturn renders the drug with slower rate of absorption from the buccal route; hence dissolution is the rate limiting step for such lipophilic drugs. So, there is a need to keep a check on the dissolution profile of these drugs to ensure maximum therapeutic utilization. The dissolution rate therefore becomes a primary factor which governs the rate and extent of its absorption. Enormous work is being performed in the field of enhancement of solubility and dissolution behaviour of such drugs. Advancements and innovations ha

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Molavi, Fatima, Hamed Hamishehkar, and Ali Nokhodchi. "Impact of Tablet Shape on Drug Dissolution Rate Through Immediate Released Tablets." Advanced Pharmaceutical Bulletin 10, no. 4 (2020): 656–61. http://dx.doi.org/10.34172/apb.2020.079.

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Purpose : The aim of this study was to evaluate the influence of the geometric shape on the dissolution rate of the domperidone, a drug model for immediate release dosage form. In this regard, a lack of sufficient information about the effective dissolution rate of the drugs regarding their shapes has made this issue an interesting subject for researchers. Methods: For this purpose, three tablet shapes, namely flat and biconvex both in a round and oblong shapes, with different four sizes were modelled for the preparation of domperidone tablet. In vitro dissolution test was accomplished using a

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Chatap, V. K., and Deshbandhu Joshi. "Recent Advanced of Multiple Unite Pellet System (MUPS) Technology in Formulation of Pharmaceutical Products: A Review." International Journal of Contemporary Research and Review 9, no. 10 (2020): 20202–14. http://dx.doi.org/10.15520/ijcrr.v9i10.879.

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The oral route of drug administration is the most important and most user-friendly route of administration. In recent years, Multiple Unit Pellet Systems (MUPS) tablets are widely used in solid dosage form design. MUPS is considered to provide pharmacokinetic advantages compared to monolithic dosage forms. Combination of drug substances and release profiles can be provided by formulating the MUPS tablets with different pellet qualities or combining pellets with drugs in powder or granulated form. MUPS tablet contains several hundred of coated pellets of active pharmaceutical ingredients which

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Khan, Azhar Danish. "COMPARATIVE QUALITY EVALUATION OF TWO BRANDS OF PARACETAMOL TABLETS OBTAINED FROM THE MARKET." INTERNATIONAL JOURNAL OF PHARMACEUTICAL EDUCATION AND RESEARCH (IJPER) 1, no. 1 (2019): 14–18. http://dx.doi.org/10.37021/ijper.v1i1.14.

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Introduction: Paracetamol tablets are very common over the counter (OTC) products among the patients as a good analgesics s. It is the drug of choice in patients that cannot be treated with non-steroidal anti-inflammatory drugs (NSAID), such as people with bronchial asthma, peptic ulcer disease, hemophilia, salicylate-sensitized people and children under 12 years of age, pregnant or breastfeeding women. Objective: The objective of this study was to compare the quality of the paracetamol tablet formulations those are locally available in India pharmaceutical market manufactured by various pharm

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Shani, Jashovam, Shimon Benita, Muhamed Abdulrazik, and Aharon Yerushalmi. "Efficacy of Sustained-Release Radioprotective Drugs in vivo." Zeitschrift für Naturforschung C 42, no. 11-12 (1987): 1323–27. http://dx.doi.org/10.1515/znc-1987-11-1229.

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In previous publications from this laboratory we suggested the use of radioprotective drugs in a sustained-release form as a practical way to cope with their high toxicity and quick metabolism and excretion. Cysteine and cysteamine, well-established radioprotectants, were used as model drugs and compressed at various concentrations (0-65%) into an insoluble tablet matrix, composed of ethylcellulose and stearic acid at various ratios and compression pressures. We demonstrated in vitro that when the release rate of the radioprotectants was measured under nitrogen, the kinetic data conformed with

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Pundir, Sarika, and Ashutosh Badola. "Formulation and Evaluation of Atenolol and Indapamide SR Matrix Tablet for Treatment of Hypertension." International Journal of Pharmaceutical and Life Sciences 2, no. 4 (2013): 141–57. http://dx.doi.org/10.3329/ijpls.v2i4.17114.

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In the present study we have formulated (f1 to f6) matrix tablets of Atenolol and Indapamide for the management of hypertension. As in simultaneous estimation of these drugs it was found that a confined release can be formulated. In the formulation of SR matrix tablet by using different concentration of delayed release agent DCP and pregelatinised starch as disintegrant we prepared tablets by wet granulation method. For sustained release action HPMC polymers were used for film coating. Preformulation studies were performed prior to compression. The compressed SR matrix tablets were evaluated f

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Sungthongjeen, Srisagul, and Satit Puttipipatkhachorn. "Comparison between Ethylcellulose Aqueous Colloidal Dispersion and Ethylcellulose Ethanolic Solution as Rupturable Coating Materials for Pulsatile Release Tablets." Advanced Materials Research 506 (April 2012): 489–92. http://dx.doi.org/10.4028/www.scientific.net/amr.506.489.

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Pulsatile release dosage forms which time of drug release can be determined have shown advantages for various drugs such as chronopharmacological drugs and drugs with high first pass metabolism. The pulsatile release tablets consisting of drug-containing cores coated with inner swelling layer containing a superdisintegrant (croscarmellose sodium (Ac-Di-Sol®)) and outer rupturable layer (ethylcellulose (EC)) were previously developed. In this study, two different types of EC coating membrane, EC ethanolic solution (ECS) versus EC aqueous colloidal dispersion (ECD), were compared. Propranolol HC

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H. Aodah, Alhussain, Mohamed H. Fayed, Ahmed Alalaiwe, Bader B. Alsulays, Mohammed F. Aldawsari, and El-Sayed Khafagy. "Design, Optimization, and Correlation of In Vitro/In Vivo Disintegration of Novel Fast Orally Disintegrating Tablet of High Dose Metformin Hydrochloride Using Moisture Activated Dry Granulation Process and Quality by Design Approach." Pharmaceutics 12, no. 7 (2020): 598. http://dx.doi.org/10.3390/pharmaceutics12070598.

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Compression of cohesive, poorly compactable, and high-dose metformin hydrochloride into the orally disintegrating tablet (ODT) is challenging. The objective of this study was to develop metformin ODT using the moisture activated dry granulation (MADG) process. There are no reports in the literature regarding the development of ODT based on MADG technology. The feasibility of developing metformin ODT was assessed utilizing a 32 full factorial design to elucidate the influence of water amount (X1) and the amount of pregelatinized starch (PGS; X2) as independent variables on key granules and tabl

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Singh, Abhay, Sudip Das, Sabnam Gupta, and Suman Ghosh. "The Challenges of Producing Bilayer Tablet: A Review." Journal of Drug Delivery and Therapeutics 11, no. 4-S (2021): 171–75. http://dx.doi.org/10.22270/jddt.v11i4-s.4922.

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Bilayer tablets are the advanced form of conventional immediate release tablet system, which consist of either two similar or different drugs combined in a single dose for effective treatment of the disease improving patient compliance. However, the multilayer tablet technology is demanding It also necessitates meticulous selection of excipients and manufacturing conditions for each technological stage. The aim of this review is to provide an outline of state of art of bilayer tablet technology and emphasise the difficulties experienced during Bilayer tablet manufacturing along with its intend

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Sawatdee, Somchai, Apichart Atipairin, Attawadee Sae Yoon, Teerapol Srichana, Narumon Changsan, and Tan Suwandecha. "Formulation Development of Albendazole-Loaded Self-Microemulsifying Chewable Tablets to Enhance Dissolution and Bioavailability." Pharmaceutics 11, no. 3 (2019): 134. http://dx.doi.org/10.3390/pharmaceutics11030134.

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Albendazole is an anthelmintic agent with poor solubility and absorption. We developed a chewable tablet (200 mg drug equivalent), containing a self-microemulsifying drug delivery system (SMEDDS), with oral disintegrating properties. The emulsion was developed using sesame and soybean oils along with surfactant/co-surfactants, and the tablets were prepared by wet granulation using superdisintegrants and adsorbents. Infra-red (IR) spectral studies revealed no interaction between the drug and excipients, and all physical and chemical parameters were within acceptable limits. Stability studies fo

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Zgonjanin, Dragana, Eva Loncar, and Milos Tasic. "Analysis of forensic samples of "Ecstasy" tablets seized in Novi Sad during the 2004 year." Acta Periodica Technologica, no. 36 (2005): 247–59. http://dx.doi.org/10.2298/apt0536247z.

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The paper presents results of the analysis of illicit synthetic drugs in the form of tablets distributed under the name "Ecstasy", seized by the police in the broader area of Novi Sad 2004. A huge number of tablets has been analyzed (n=121), of various colours and with impressed symbols from the total amount of 93 seizures, which totally amounted to 1458 tablets. Regarding the number of seizures ecstasy (3,4-methylendioxy-N-meth-yl-amphetamine - MDMA) is dominant among all, and according to the quantity of seized tablets it is amphetamine (AP), while other amphetamine-type drugs (methamphetami

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Shen, Yudong, Xingya Li, and Yuan Le. "Amorphous Nanoparticulate Formulation of Sirolimus and Its Tablets." Pharmaceutics 10, no. 3 (2018): 155. http://dx.doi.org/10.3390/pharmaceutics10030155.

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Nanocrystallization and amorphization have proven to be two effective strategies to improve the bioavailability of water-insoluble drugs. The purpose of our work was to develop a nano-formulated tablet of sirolimus (SRL) for enhanced dissolution. Amorphous SRL nanocomposites were prepared using anti-solvent precipitation via a high-gravity rotating packed bed. Various factors that affect particle size and size distribution, such as excipients, rotating speed, antisolvent/solvent flow rate, were investigated. Structure, stability and in vitro dissolution of the as-prepared SRL were evaluated. F

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