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Journal articles on the topic 'Talins and Cancer'

Author: Grafiati

Published: 4 June 2025

Last updated: 1 August 2025

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1

Mahmoud, Youns. "Talins and Cancer." Journal of Clinical Microbiology and Biochemical Technology 3, no. 1 (2017): 017–18. https://doi.org/10.17352/jcmbt.000020.

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Talin is a large cytoskeletal adaptor protein that is an important component of focal adhesion complexes of adherent cells. It was originally identified as a component of focal adhesions and ruffling membranes of fibroblasts. It was the first cytoplasmic protein partner of integrins to be identified. Many studies proved that talin connects the intracellular actin cytoskeleton with the extracellular environment through interactions with integral membrane proteins in the dynamic focal adhesions. The modular structure of talin is responsible for its ability to serve as a linker protein. It was th

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Malla, Rama Rao, and Rahul Kumar Vempati. "Talin: A Potential Drug Target for Cancer Therapy." Current Drug Metabolism 21, no. 1 (2020): 25–32. http://dx.doi.org/10.2174/1389200221666200214114018.

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Talin is an intracellular cytoskeletal protein and one of the major components of the focal adhesion complex. It mainly acts as an interlink between transmembrane integrin receptors and cytosolic F-actin. Apart from integrins and actin, it also interacts with various other proteins in the adhesion complex to regulate their functional dynamics. Talin undergoes a variety of post-translational modifications and they are implicated in the control of cell motility. There are two talin isoforms (talin1 and talin2) in mammals and they are encoded by TLN1 and TLN2 genes, respectively. Recent studies s

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Baster, Zbigniew, Lindsay Russell, and Zenon Rajfur. "A Review of Talin- and Integrin-Dependent Molecular Mechanisms in Cancer Invasion and Metastasis." International Journal of Molecular Sciences 26, no. 5 (2025): 1798. https://doi.org/10.3390/ijms26051798.

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Cancer is the second most common cause of death in the world, representing one of the main economic burdens in health care and research. The effort of research has mainly focused on limiting the growth of a localized tumor, but most recently, there has been more attention focused on restricting the spreading of the cancer via invasion and metastasis. The signaling pathways behind these two processes share many molecules with physiological pathways regulating cell adhesion and migration, and, moreover, adhesion and migration processes themselves underlie tumor potential for invasion. In this wo

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Chinthalapudi, Krishna, Erumbi S. Rangarajan, and Tina Izard. "The interaction of talin with the cell membrane is essential for integrin activation and focal adhesion formation." Proceedings of the National Academy of Sciences 115, no. 41 (2018): 10339–44. http://dx.doi.org/10.1073/pnas.1806275115.

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Multicellular organisms have well-defined, tightly regulated mechanisms for cell adhesion. Heterodimeric αβ integrin receptors play central roles in this function and regulate processes for normal cell functions, including signaling, cell migration, and development, binding to the extracellular matrix, and senescence. They are involved in hemostasis and the immune response, participate in leukocyte function, and have biological implications in angiogenesis and cancer. Proper control of integrin activation for cellular communication with the external environment requires several physiological p

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Lu, Ziyao, Shahab Haghollahi, and Muhammad Afzal. "Potential Therapeutic Targets for the Treatment of HPV-Associated Malignancies." Cancers 16, no. 20 (2024): 3474. http://dx.doi.org/10.3390/cancers16203474.

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This review article aims to summarize broadly recent developments in the treatment of HPV-associated cancers, including cervical cancer and head and neck squamous cell carcinoma. Relatively new treatments targeting the key HPV E6 and E7 oncoproteins, including gene editing with TALENs and CRISPR/Cas9, are discussed. Given the increased immunogenicity of HPV-related diseases, other therapies such as PRR agonists, adoptive cell transfer, and tumor vaccines are reaching the clinical trial phase. Due to the mechanism, immunogenicity, and reversibility of HPV carcinogenesis, HPV-related cancers pre

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Yu, Chenghan. "Applications of the CRISPR-Cas9 system in the treatment of KRAS mutated lung cancer." Theoretical and Natural Science 21, no. 1 (2023): 215–19. http://dx.doi.org/10.54254/2753-8818/21/20230868.

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Lung cancer is currently the most prevailed cancer in men, and the second most prevailed cancer in women. It is by far the most fatal cancer with around 21% of overall death from cancer. It is very important to seek a way to treat lung cancers, since too many people died for lung cancers, too many families broke up and collapsed, and too many people are left with broken spirituality and heart. On the other hand, the successful treatment of lung cancer using method of gene editing could symbolize for the success of the appliance of gene editing on other deadly cancers. The main type of gene edi

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Abe, Toshiya, Kenoki Ohuchida, Sho Endo, et al. "Talin1 promotes tumor invasion in pancreatic cancer." Pancreatology 16, no. 4 (2016): S85. http://dx.doi.org/10.1016/j.pan.2016.06.306.

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Hwang, Bor-Jang, Gabrielle Edwards, Cole Davis Knoblich, Khosrow Rezvani, and Valerie Odero-Marah. "Abstract C081: Exploring signaling pathways of tumor-nerve interactions in breast cancer." Cancer Epidemiology, Biomarkers & Prevention 33, no. 9_Supplement (2024): C081. http://dx.doi.org/10.1158/1538-7755.disp24-c081.

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Abstract Abstract Introduction: Among the breast cancer, Triple Negative Breast Cancer (TNBC) is usually aggressive and invasive. In the United States, Black women have the highest TNBC incidence (25.2 per 100,000 women) which is almost double compared to other races (9∼13 per 100,000). Neurite outgrowth also known as autonomic nerve sprouting occurs in tumors and contributes to cancer progression and metastasis. Studies on neurite outgrowth in breast cancer (BCa) are limited, however, one study indicates that TNBC cells (4T1) secrete cytokines that induce neurite outgrowth in neurons, while r

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Paris, Elizabeth, Pincas Bitterman, Sameer Sharma, Sanjib Basu, Janice M. Bahr, and Animesh Barua. "Changes in focal adhesion protein Talin-1 expression during malignant transformation leading to ovarian high-grade serous carcinoma." Journal of Clinical Oncology 40, no. 16_suppl (2022): e17586-e17586. http://dx.doi.org/10.1200/jco.2022.40.16_suppl.e17586.

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e17586 Background: Ovarian high-grade serous carcinoma (HGSC), the most lethal form of ovarian cancer, is often detected at late stages due to the lack of an early detection test resulting in low 5-year survival rates. Information on factors associated with malignant transformation and early metastasis is critical in developing interventional strategies to reduce the incidence and death due to HGSC. Talin-1, a focal adhesion protein, regulates cell–cell adhesion, and induces cytoskeletal remodeling leading to tumor cell migration and adhesion. Destabilization of the cell membrane during malign

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Paris, Elizabeth, Pincas Bitterman, Sameer Sharma, Sanjib Basu, Janice M. Bahr, and Animesh Barua. "Changes in focal adhesion protein Talin-1 expression during malignant transformation leading to ovarian high-grade serous carcinoma." Journal of Clinical Oncology 40, no. 16_suppl (2022): e17586-e17586. http://dx.doi.org/10.1200/jco.2022.40.16_suppl.e17586.

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e17586 Background: Ovarian high-grade serous carcinoma (HGSC), the most lethal form of ovarian cancer, is often detected at late stages due to the lack of an early detection test resulting in low 5-year survival rates. Information on factors associated with malignant transformation and early metastasis is critical in developing interventional strategies to reduce the incidence and death due to HGSC. Talin-1, a focal adhesion protein, regulates cell–cell adhesion, and induces cytoskeletal remodeling leading to tumor cell migration and adhesion. Destabilization of the cell membrane during malign

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Hwang, Bor-Jang, Gabrielle J. Edwards, Cole Davis Knoblich, Khosrow Rezvani, and Valerie Odero-Marah. "Abstract 5390: Exploring signaling pathways of tumor-nerve interactions in prostate and breast cancer." Cancer Research 84, no. 6_Supplement (2024): 5390. http://dx.doi.org/10.1158/1538-7445.am2024-5390.

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Abstract A significant portion of prostate cancer (PCa) and breast cancer (BCa) patients develop bone metastatic disease. In some cases, cancer spreads through the nervous system, a process known as perineural invasion (PNI). Neurite outgrowth is believed to be a precursor to PNI. Snail is an important gene which regulates the epithelial-mesenchymal transition (EMT) process in which tumor cells at the invasive front undergo this transition to promote invasion, migration, and subsequent metastasis. We recently published that Snail promotes neurite outgrowth in PCa cells. We hypothesize that Sna

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Mohamed, Amal A., Naglaa El-Toukhy, Doaa M. Ghaith, et al. "Talin-1 Gene Expression as a Tumor Marker in Hepatocellular Carcinoma Patients: A Pilot Study." Open Biomarkers Journal 10, no. 1 (2020): 15–22. http://dx.doi.org/10.2174/1875318302010010015.

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Background & Aims: Hepatocellular Carcinoma (HCC) is the most common primary liver tumor. It is the second most common cancer in men and the sixth in women in Egypt. One of the proteins participating in the trans-endothelial migration is Talin-1. It also has a role in the formation and metastasis of different types of cancer. This study aimed to evaluate the diagnostic impact of Talin-1 gene expression in HCC Egyptian patients. Methods: Our study included forty HCC patients, thirty liver cirrhosis patients without HCC and thirty healthy subjects. For all groups, clinical and biochemical pa

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Beaty, Brian T., Yarong Wang, Jose Javier Bravo-Cordero, et al. "Talin regulates moesin–NHE-1 recruitment to invadopodia and promotes mammary tumor metastasis." Journal of Cell Biology 205, no. 5 (2014): 737–51. http://dx.doi.org/10.1083/jcb.201312046.

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Invadopodia are actin-rich protrusions that degrade the extracellular matrix and are required for stromal invasion, intravasation, and metastasis. The role of the focal adhesion protein talin in regulating these structures is not known. Here, we demonstrate that talin is required for invadopodial matrix degradation and three-dimensional extracellular matrix invasion in metastatic breast cancer cells. The sodium/hydrogen exchanger 1 (NHE-1) is linked to the cytoskeleton by ezrin/radixin/moesin family proteins and is known to regulate invadopodium-mediated matrix degradation. We show that the ta

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Strömblad, Staffan. "Cancer biology: Hypoxia-induced talin tail-docking sparks cancer metastasis." Current Biology 32, no. 2 (2022): R79—R81. http://dx.doi.org/10.1016/j.cub.2021.11.045.

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15

Ajutor, Lawrence John, Okabeonye Sunday Agbo, Christian Ajiri Adobor, et al. "Gene Editing in Cancer Immunotherapy: Mechanisms, Advancements, Limitations and Future Directions." Asian Journal of Biochemistry, Genetics and Molecular Biology 16, no. 12 (2024): 121–35. https://doi.org/10.9734/ajbgmb/2024/v16i12428.

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Gene editing has emerged as a transformative approach in cancer immunotherapy. Several gene editing tools have been employed for precise modification of the DNA of immune cells, enhancing their ability to target and eliminate cancer cells. This review examines the evolution and applications of key gene-editing tools, such as CRISPR-Cas9, TALENs, ZFNs, and recent innovations like base and prime editing in the field of cancer immunotherapy. Promising results have been observed in therapies such as CAR-T and tumor-infiltrating lymphocyte (TIL) treatments, which have shown success in cancers like

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Ito, Hiromi, Yuki Takai, Sei Naito, Takafumi Narisawa, and Norihiko Tsuchiya. "Abstract 2646: Ankrd1 enhances lamellipodia formation and cell motility in clear cell renal cell carcinoma." Cancer Research 85, no. 8_Supplement_1 (2025): 2646. https://doi.org/10.1158/1538-7445.am2025-2646.

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Abstract Introduction: Clear cell renal cell carcinoma (ccRCC) displays more mesenchymal traits compared to other cancers. These traits include mesenchymal motility, which involves membrane protrusions like lamellipodia formed by actin polymerization. Ankyrin repeat domain 1 (Ankrd1) is regulated by YAP and ERK5, and contains structures that facilitate protein-protein interaction. Ankrd1 has been linked to epithelial-mesenchymal transition (EMT), cancer progression, and drug resistance in various cancers. However, its role in ccRCC remains unexplored. This study investigates Ankrd1 expression,

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He, Zhengxiu, Jian Sun, Mengmeng Wang, Shanshan Chen, Guoxin Mao, and Li Yang. "Talin1 Ser425 phosphorylation promotes colorectal cancer progression and metastasis." Translational Cancer Research 14, no. 2 (2025): 796–807. https://doi.org/10.21037/tcr-24-1283.

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Jang, Yoon-Kwan, Jung-Soo Suh, Gyuho Choi, et al. "Abstract 5816: Tensin1 tension sensor reveals novel features associated with actomyosin, focal adhesion dynamics, and mechanosensitivity." Cancer Research 83, no. 7_Supplement (2023): 5816. http://dx.doi.org/10.1158/1538-7445.am2023-5816.

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Abstract Cellular responses to mechanical stimuli play an imperative role in the regulation of physiological and pathological functions. Unlike other integrin-mediated adhesion proteins, the force transmission mechanism of tensin1 is not well understood. In this study, we describe the development and visualization of a tensin1 tension sensor. A signal from this sensor indicates that tensin1 is under greater tension at peripheral adhesions than at central adhesions, and that it is controlled by actomyosin in fibroblasts. In a bidirectional manner, tension in tensin1 is regulated by focal adhesi

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Powner, Dale, Petra M. Kopp, Susan J. Monkley, David R. Critchley, and Fedor Berditchevski. "Tetraspanin CD9 in cell migration." Biochemical Society Transactions 39, no. 2 (2011): 563–67. http://dx.doi.org/10.1042/bst0390563.

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Tetraspanin CD9 is associated with integrin adhesion receptors and it was reported that CD9 regulates integrin-dependent cell migration and invasion. Pro- and anti-migratory effects of CD9 have been linked to adhesion-dependent signalling pathways, including phosphorylation of FAK (focal adhesion kinase) and activation of phosphoinositide 3-kinase, p38 MAPK (mitogen-activated protein kinase) and JNK (c-Jun N-terminal kinase). In the present paper, we describe a novel mechanism whereby CD9 specifically controls localization of talin1, one of the critical regulators of integrin activation, to fo

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de Almeida, Nathália Alves Araújo, Camilla Rodrigues de Almeida Ribeiro, Jéssica Vasques Raposo, and Vanessa Salete de Paula. "Immunotherapy and Gene Therapy for Oncoviruses Infections: A Review." Viruses 13, no. 5 (2021): 822. http://dx.doi.org/10.3390/v13050822.

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Immunotherapy has been shown to be highly effective in some types of cancer caused by viruses. Gene therapy involves insertion or modification of a therapeutic gene, to correct for inappropriate gene products that cause/may cause diseases. Both these types of therapy have been used as alternative ways to avoid cancers caused by oncoviruses. In this review, we summarize recent studies on immunotherapy and gene therapy including the topics of oncolytic immunotherapy, immune checkpoint inhibitors, gene replacement, antisense oligonucleotides, RNA interference, clustered regularly interspaced shor

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Li, Liqing, Xiang Li, Lei Qi, Piotr Rychahou, Naser Jafari, and Cai Huang. "The role of talin2 in breast cancer tumorigenesis and metastasis." Oncotarget 8, no. 63 (2017): 106876–87. http://dx.doi.org/10.18632/oncotarget.22449.

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Huang, Zhiyao, Diana Barker, Jonathan M. Gibbins, and Philip R. Dash. "Talin is a substrate for SUMOylation in migrating cancer cells." Experimental Cell Research 370, no. 2 (2018): 417–25. http://dx.doi.org/10.1016/j.yexcr.2018.07.005.

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Tulkens, Dieter, Dionysia Dimitrakopoulou, Marthe Boelens, et al. "Engraftment of Allotransplanted Tumor Cells in Adult rag2 Mutant Xenopus tropicalis." Cancers 14, no. 19 (2022): 4560. http://dx.doi.org/10.3390/cancers14194560.

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Modeling human genetic diseases and cancer in lab animals has been greatly aided by the emergence of genetic engineering tools such as TALENs and CRISPR/Cas9. We have previously demonstrated the ease with which genetically engineered Xenopus models (GEXM) can be generated via injection of early embryos with Cas9 recombinant protein loaded with sgRNAs targeting single or multiple tumor suppressor genes. What has been lacking so far is the possibility to propagate and characterize the induced cancers via transplantation. Here, we describe the generation of a rag2 knockout line in Xenopus tropica

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Takai, Yuki, Sei Naito, Hiromi Ito, et al. "Ankrd1 Promotes Lamellipodia Formation and Cell Motility via Interaction with Talin-1 in Clear Cell Renal Cell Carcinoma." International Journal of Molecular Sciences 26, no. 9 (2025): 4232. https://doi.org/10.3390/ijms26094232.

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Ankyrin repeat domain 1 (Ankrd1), a transcriptional target of Yes-associated protein (YAP), is linked to cardiomyopathy. However, its role in cancer, particularly in clear cell renal cell carcinoma (ccRCC), remains vague. In this study, we examined the expression, regulation, and function of Ankrd1 in ccRCC. High Ankrd1 expression was related to poor prognosis in patients with ccRCC in The Cancer Genome Atlas cohort. Ankrd1 expression was regulated by YAP in all ccRCC cell lines examined and also by ERK5 in a subset of ccRCC cell lines. Moreover, silencing of Ankrd1 in ccRCC cell lines resulte

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Sakamoto, Shinichi, Richard O. McCann, Rajiv Dhir, and Natasha Kyprianou. "Talin1 Promotes Tumor Invasion and Metastasis via Focal Adhesion Signaling and Anoikis Resistance." Cancer Research 70, no. 5 (2010): 1885–95. http://dx.doi.org/10.1158/0008-5472.can-09-2833.

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Zhang, Junxin. "Progress of CRISPR Technology in Cancer Treatment." Highlights in Science, Engineering and Technology 109 (July 24, 2024): 44–52. http://dx.doi.org/10.54097/jeb0b074.

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The CRISPR (Cluster of regularly interspersed short palindromic repeats) technology is the nowadays trend of genetic engineering. The simplicity of the system has made genetic engineering more applicable and convenient for bioengineers, in comparison to ZFNs and TALENs. It is now used in a wide range of aspect, by inserting, deleting, silencing, mutating the target gene. However, this technology still has drawbacks. Off-target affect, one of the most common shortcoming has made this technology often considered to be too risky to be put in actual treatment. CRISPR technology holds a great promi

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Munuru, Srikanth, Swamy Uttaravilli Manikanta, Sharmila Begum Shaik, Bharati Mollety, and R. V. Geetha. "CRISPR/Cas gene editing based therapy approach in clinical therapeutics." Research Journal of Biotechnology 8, no. 20 (2025): 256. https://doi.org/10.25303/208rjbt2560263.

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Advanced inventions in genetic engineering towards clinical therapeutics have been rising over the past decade, which has brought a new approach in treating diseases like HIV, cancer, pulmonary diseases, genetic disorders, hereditary transferring disorders etc. Gene editing-based therapy holds specific molecular tools i.e. ZFN, TALENS and CRISPR/Cas9. These gene-editing techniques show precise and accurate modification of the eukaryotic genome. The application of CRISPR/Cas had become a trending gene-editing technique as its effectiveness in editing was comparatively high. Nowadays, gene-editi

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Cortesio, Christa L., Keefe T. Chan, Benjamin J. Perrin, et al. "Calpain 2 and PTP1B function in a novel pathway with Src to regulate invadopodia dynamics and breast cancer cell invasion." Journal of Cell Biology 180, no. 5 (2008): 957–71. http://dx.doi.org/10.1083/jcb.200708048.

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Invasive cancer cells form dynamic adhesive structures associated with matrix degradation called invadopodia. Calpain 2 is a calcium-dependent intracellular protease that regulates adhesion turnover and disassembly through the targeting of specific substrates such as talin. Here, we describe a novel function for calpain 2 in the formation of invadopodia and in the invasive abilities of breast cancer cells through the modulation of endogenous c-Src activity. Calpain-deficient breast cancer cells show impaired invadopodia formation that is rescued by expression of a truncated fragment of protein

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Sakamoto, Shinichi, Richard O. McCann, Rajiv Dhir, Tomohiko Ichikawa, and Natasha Kyprianou. "TALIN1 IS A NOVEL MEDIATOR OF PROSTATE CANCER CELL MIGRATION, INVASION, AND METASTASIS." Journal of Urology 181, no. 4S (2009): 474. http://dx.doi.org/10.1016/s0022-5347(09)61342-2.

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Tripathi, Brajendra K., Xiaolan Qian, Philipp Mertins, et al. "CDK5 is a major regulator of the tumor suppressor DLC1." Journal of Cell Biology 207, no. 5 (2014): 627–42. http://dx.doi.org/10.1083/jcb.201405105.

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DLC1 is a tumor suppressor protein whose full activity depends on its presence at focal adhesions, its Rho–GTPase activating protein (Rho-GAP) function, and its ability to bind several ligands, including tensin and talin. However, the mechanisms that regulate and coordinate these activities remain poorly understood. Here we identify CDK5, a predominantly cytoplasmic serine/threonine kinase, as an important regulator of DLC1 functions. The CDK5 kinase phosphorylates four serines in DLC1 located N-terminal to the Rho-GAP domain. When not phosphorylated, this N-terminal region functions as an aut

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Wei, Xiaofan, Xiang Wang, Jun Zhan, et al. "Smurf1 inhibits integrin activation by controlling Kindlin-2 ubiquitination and degradation." Journal of Cell Biology 216, no. 5 (2017): 1455–71. http://dx.doi.org/10.1083/jcb.201609073.

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Integrin activation is an indispensable step for various integrin-mediated biological functions. Kindlin-2 is known to coactivate integrins with Talin; however, molecules that restrict integrin activation are elusive. Here, we demonstrate that the E3 ubiquitin ligase Smurf1 controls the amount of Kindlin-2 protein in cells and hinders integrin activation. Smurf1 interacts with and promotes Kindlin-2 ubiquitination and degradation. Smurf1 selectively mediates degradation of Kindlin-2 but not Talin, leading to inhibition of αIIbβ3 integrin activation in Chinese hamster ovary cells and β1 integri

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Sakamoto, Shinichi, Richard McCann, and Natasha Kyprianou. "TALIN AS A NOVEL MEDIATOR OF PROSTATE CANCER CELL MIGRATION, INVASION AND METASTASIS." Journal of Urology 179, no. 4S (2008): 459–60. http://dx.doi.org/10.1016/s0022-5347(08)61349-x.

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de Semir, David, Vladimir Bezrookove, Mehdi Nosrati, et al. "PHIP as a therapeutic target for driver-negative subtypes of melanoma, breast, and lung cancer." Proceedings of the National Academy of Sciences 115, no. 25 (2018): E5766—E5775. http://dx.doi.org/10.1073/pnas.1804779115.

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The identification and targeting of key molecular drivers of melanoma and breast and lung cancer have substantially improved their therapy. However, subtypes of each of these three common, lethal solid tumors lack identified molecular drivers, and are thus not amenable to targeted therapies. Here we show that pleckstrin homology domain-interacting protein (PHIP) promotes the progression of these “driver-negative” tumors. Suppression of PHIP expression significantly inhibited both tumor cell proliferation and invasion, coordinately suppressing phosphorylated AKT, cyclin D1, and talin1 expressio

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Jin, J.-K., P.-C. Tien, C.-J. Cheng та ін. "Talin1 phosphorylation activates β1 integrins: a novel mechanism to promote prostate cancer bone metastasis". Oncogene 34, № 14 (2014): 1811–21. http://dx.doi.org/10.1038/onc.2014.116.

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Jevnikar, Zala, Matija Rojnik, Polona Jamnik, Bojan Doljak, Urša Pečar Fonović, and Janko Kos. "Cathepsin H Mediates the Processing of Talin and Regulates Migration of Prostate Cancer Cells." Journal of Biological Chemistry 288, no. 4 (2012): 2201–9. http://dx.doi.org/10.1074/jbc.m112.436394.

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Muschler, John L., Ge Huang, Alexander C. Smith та Rosalie C. Sears. "Abstract B098: Oncogenic KRAS relies on β1 integrin expression to drive pancreatic neoplasia and PDAC development". Cancer Research 84, № 2_Supplement (2024): B098. http://dx.doi.org/10.1158/1538-7445.panca2023-b098.

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Abstract Oncogenic Kras drives cancer progression through cooperation with multiple cellular factors, many of which are yet to be determined. The β1 integrins, a family of extracellular matrix receptors, are strong candidates; they are implicated in many aspects of cancer progression including cell growth and survival signaling, cell migration and metastasis. Additionally, multiple studies have identified β1 integrins within the interactome of oncogenic Kras. We are investigating the potential cooperation if β1 integrins in Kras-mediated oncogenesis using genetic perturbations within the tamox

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Liu, Tianye. "Applications of CRISPR-Cas9 Technology in Editing Telomeres and Their Related Control Genes." Theoretical and Natural Science 82, no. 1 (2025): 39–44. https://doi.org/10.54254/2753-8818/2024.ka20159.

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CRISPR-Cas9, awarded the 2020 Nobel Prize in Chemistry for its discovery by Jennifer Doudna and Emmanuelle Charpentier, has revolutionized gene editing due to its versatility, precision, and efficiency. Unlike previous gene editing tools such as Zinc Finger Proteins (ZFP) and TALENs, CRISPR-Cas9 allows targeted editing of any DNA sequence with minimal off-target effects. This article explores the potential of CRISPR-Cas9 technology to edit telomeresprotective DNA structures at chromosome endsand related genes to address telomere-associated diseases and aging mechanisms. Telomeres, consisting o

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Hoskin, Victoria, Alvin Szeto, Abdi Ghaffari, Peter A. Greer, Graham P. Côté, and Bruce E. Elliott. "Ezrin regulates focal adhesion and invadopodia dynamics by altering calpain activity to promote breast cancer cell invasion." Molecular Biology of the Cell 26, no. 19 (2015): 3464–79. http://dx.doi.org/10.1091/mbc.e14-12-1584.

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Up-regulation of the cytoskeleton linker protein ezrin frequently occurs in aggressive cancer types and is closely linked with metastatic progression. However, the underlying molecular mechanisms detailing how ezrin is involved in the invasive and metastatic phenotype remain unclear. Here we report a novel function of ezrin in regulating focal adhesion (FA) and invadopodia dynamics, two key processes required for efficient invasion to occur. We show that depletion of ezrin expression in invasive breast cancer cells impairs both FA and invadopodia turnover. We also demonstrate that ezrin-deplet

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Baster, Zbigniew, Liqing Li, Sampo Kukkurainen, et al. "Cyanidin‐3‐glucoside binds to talin and modulates colon cancer cell adhesions and 3D growth." FASEB Journal 34, no. 2 (2020): 2227–37. http://dx.doi.org/10.1096/fj.201900945r.

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Meng, Fanrui, Sandeep Saxena, Youtao Liu, et al. "The phospho–caveolin-1 scaffolding domain dampens force fluctuations in focal adhesions and promotes cancer cell migration." Molecular Biology of the Cell 28, no. 16 (2017): 2190–201. http://dx.doi.org/10.1091/mbc.e17-05-0278.

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Caveolin-1 (Cav1), a major Src kinase substrate phosphorylated on tyrosine-14 (Y14), contains the highly conserved membrane-proximal caveolin scaffolding domain (CSD; amino acids 82–101). Here we show, using CSD mutants (F92A/V94A) and membrane-permeable CSD-competing peptides, that Src kinase–dependent pY14Cav1 regulation of focal adhesion protein stabilization, focal adhesion tension, and cancer cell migration is CSD dependent. Quantitative proteomic analysis of Cav1-GST (amino acids 1–101) pull downs showed sixfold-increased binding of vinculin and, to a lesser extent, α-actinin, talin, and

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Yokoyama, Yasuhiro, Tetsushi Ito, Veneta Hanson, et al. "PMA-induced reduction in invasiveness is associated with hyperphosphorylation of MARCKS and talin in invasive bladder cancer cells." International Journal of Cancer 75, no. 5 (1998): 774–79. http://dx.doi.org/10.1002/(sici)1097-0215(19980302)75:5<774::aid-ijc18>3.0.co;2-6.

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Halder, Arundhati, Kasturi Bala Nayak, and Soumen Chakraborty. "Ecotopic viral integration site 1 (EVI1) transcriptionally targets talin1 (TLN1) and upregulates its expression in chronic myeloid leukemia." Leukemia & Lymphoma 59, no. 8 (2017): 2008–10. http://dx.doi.org/10.1080/10428194.2017.1406089.

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Lai, Ming-Tsung, Chun-Hung Hua, Ming-Hsui Tsai, et al. "Talin-1 overexpression defines high risk for aggressive oral squamous cell carcinoma and promotes cancer metastasis." Journal of Pathology 224, no. 3 (2011): 367–76. http://dx.doi.org/10.1002/path.2867.

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Volberg, Tova, Helena Sabanay, and Benjamin Geiger. "Spatial and temporal relationships between vinculin and talin in the developing chicken gizzard smooth muscle." Differentiation 32, no. 1 (1986): 34–43. http://dx.doi.org/10.1111/j.1432-0436.1986.tb00553.x.

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Sakai, Yoshiki, Tatsuhiro Shimizu, Mayuka Tsunekawa, Naoki Hisamoto, and Kunihiro Matsumoto. "Rhotekin regulates axon regeneration through the talin–Vinculin–Vinexin axis in Caenorhabditis elegans." PLOS Genetics 19, no. 12 (2023): e1011089. http://dx.doi.org/10.1371/journal.pgen.1011089.

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Axon regeneration requires actomyosin interaction, which generates contractile force and pulls the regenerating axon forward. In Caenorhabditis elegans, TLN-1/talin promotes axon regeneration through multiple down-stream events. One is the activation of the PAT-3/integrin–RHO-1/RhoA GTPase–LET-502/ROCK (Rho-associated coiled-coil kinase)–regulatory non-muscle myosin light-chain (MLC) phosphorylation signaling pathway, which is dependent on the MLC scaffolding protein ALP-1/ALP-Enigma. The other is mediated by the F-actin-binding protein DEB-1/vinculin and is independent of the MLC phosphorylat

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Ashaie, Maeirah Afzal, Rowshan Ara Islam, Nur Izyani Kamaruzman, Nabilah Ibnat, Kyi Kyi Tha, and Ezharul Hoque Chowdhury. "Targeting Cell Adhesion Molecules via Carbonate Apatite-Mediated Delivery of Specific siRNAs to Breast Cancer Cells In Vitro and In Vivo." Pharmaceutics 11, no. 7 (2019): 309. http://dx.doi.org/10.3390/pharmaceutics11070309.

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While several treatment strategies are applied to cure breast cancer, it still remains one of the leading causes of female deaths worldwide. Since chemotherapeutic drugs have severe side effects and are responsible for development of drug resistance in cancer cells, gene therapy is now considered as one of the promising options to address the current treatment limitations. Identification of the over-expressed genes accounting for constitutive activation of certain pathways, and their subsequent knockdown with specific small interfering RNAs (siRNAs), could be a powerful tool in inhibiting prol

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Chen, Xingqi. "Research on Reducing the Immunogenicity of Nucleases in Gene Therapy." Theoretical and Natural Science 96, no. 1 (2025): 97–102. https://doi.org/10.54254/2753-8818/2025.21956.

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Gene therapy, a cornerstone of precision medicine, holds transformative potential for treating genetic disorders and cancers. Despite advancements, clinical efficacy remains hindered by immune responses against therapeutic nucleases, including CRISPR-Cas9, ZFNs, and TALENs. This review evaluates strategies to rationally engineer nucleases with reduced immunogenicity while preserving editing efficiency. By synthesizing molecular insights and clinical data, three key approaches emerge: epitope masking, host compatibility optimization, and dynamic immune monitoring. Experimental evidence demonstr

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Ghaleh, Hadi E. G., Masoumeh Bolandian, Ruhollah Dorostkar, et al. "Gene therapy by using stem cells in the treatment of hepatitis." Romanian Journal of Military Medicine 124, no. 4 (2021): 498–503. http://dx.doi.org/10.55453/rjmm.2021.124.4.13.

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Chronic hepatitis can resolve spontaneously or progress to more advanced stages, i.e. fibrosis, cirrhosis, and liver cancer, respectively. Two million deaths each year are attributed to liver diseases globally. Chronic liver disease and cirrhosis comprise 11th position in leading causes of death worldwide. Viral infections account for the etiologic factor of most cases of hepatitis. Almost the only available way for the treatment of end stages of hepatitis is liver transplantation. The biggest problem with this therapeutic approach is the number of liver transplant donors is less than the numb

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Rodríguez-Fernández, Lucía, Iván Ferrer-Vicens, Concha García, et al. "Isoform-specific function of calpains in cell adhesion disruption: studies in postlactational mammary gland and breast cancer." Biochemical Journal 473, no. 18 (2016): 2893–909. http://dx.doi.org/10.1042/bcj20160198.

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Cleavage of adhesion proteins is the first step for physiological clearance of undesired cells during postlactational regression of the mammary gland, but also for cell migration in pathological states such as breast cancer. The intracellular Ca2+-dependent proteases, calpains (CAPNs), are known to cleave adhesion proteins. The isoform-specific function of CAPN1 and CAPN2 was explored and compared in two models of cell adhesion disruption: mice mammary gland during weaning-induced involution and breast cancer cell lines according to tumor subtype classification. In both models, E-cadherin, β-c

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Kanamori, Hideaki, Takao Kawakami, Kathryn Effendi, et al. "Identification by Differential Tissue Proteome Analysis of Talin-1 as a Novel Molecular Marker of Progression of Hepatocellular Carcinoma." Oncology 80, no. 5-6 (2011): 406–15. http://dx.doi.org/10.1159/000330734.

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