Relevant bibliographies by topics / Tanyctes

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Academic literature on the topic 'Tanyctes'

Author: Grafiati
Published: 16 November 2024
Last updated: 31 July 2025

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Journal articles on the topic "Tanyctes"

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Yoo, Sooyeon, Juhyun Kim, Pin Lyu, et al. "Control of neurogenic competence in mammalian hypothalamic tanycytes." Science Advances 7, no. 22 (2021): eabg3777. http://dx.doi.org/10.1126/sciadv.abg3777.

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Hypothalamic tanycytes, radial glial cells that share many features with neuronal progenitors, can generate small numbers of neurons in the postnatal hypothalamus, but the identity of these neurons and the molecular mechanisms that control tanycyte-derived neurogenesis are unknown. In this study, we show that tanycyte-specific disruption of the NFI family of transcription factors (Nfia/b/x) robustly stimulates tanycyte proliferation and tanycyte-derived neurogenesis. Single-cell RNA sequencing (scRNA-seq) and single-cell assay for transposase-accessible chromatin sequencing (scATAC-seq) analys
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Wittmann, Gabor, Surbhi Gahlot, Malcolm James Low, and Ronald M. Lechan. "Rax Expression Identifies a Novel Cell Type in the Adult Mouse Hypothalamus." Journal of the Endocrine Society 5, Supplement_1 (2021): A42. http://dx.doi.org/10.1210/jendso/bvab048.082.

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Abstract Hypothalamic tanycytes are radial glia-like ependymal cells lining the ventrolateral walls and floor of the third ventricle. Recent data show that tanycytes are adult neural stem/progenitor cells, capable of generating neurons that populate the adjacent hypothalamic nuclei involved in the regulation of feeding and energy balance. Thus, the genetic fate mapping of tanycytes has become an invaluable tool to identify and study tanycyte-derived adult-born hypothalamic neurons. Perhaps the most selective tanycyte marker identified to date is the retina and anterior neural fold homeobox (Ra
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Bolborea, Matei, Marie-Pierre Laran-Chich, Kamontip Rasri, et al. "Melatonin Controls Photoperiodic Changes in Tanycyte Vimentin and Neural Cell Adhesion Molecule Expression in the Djungarian Hamster (Phodopus sungorus)." Endocrinology 152, no. 10 (2011): 3871–83. http://dx.doi.org/10.1210/en.2011-1039.

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The Djungarian hamster displays photoperiodic variations in gonadal size synchronized to the seasons by the nightly secretion of the pineal hormone melatonin. In short photoperiod (SP), the gonads regress in size, and circulating sex steroids levels decline. Thus, the brain is subject to seasonal variations of both melatonin and sex steroids. Tanycytes are specialized glial cells located in the ependymal lining of the third ventricle. They send processes either to the meninges or to blood vessels of the medio-basal hypothalamus. Furthermore, they are known to locally modulate GnRH release in t
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de Vries, E. M., J. Kwakkel, L. Eggels та ін. "NFκB Signaling Is Essential for the Lipopolysaccharide-Induced Increase of Type 2 Deiodinase in Tanycytes". Endocrinology 155, № 5 (2014): 2000–2008. http://dx.doi.org/10.1210/en.2013-2018.

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The enzyme type 2 deiodinase (D2) is a major determinant of T3 production in the central nervous system. It is highly expressed in tanycytes, a specialized cell type lining the wall of the third ventricle. During acute inflammation, the expression of D2 in tanycytes is up-regulated by a mechanism that is poorly understood at present, but we hypothesized that cJun N-terminal kinase 1 (JNK1) and v-rel avian reticuloendotheliosis viral oncogene homolog A (RelA) (the 65 kD subunit of NFκB) inflammatory signal transduction pathways are involved. In a mouse model for acute inflammation, we studied t
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Jawad, Haider, Muthanna Al-Kaabi, and Anam Al-Salihi. "IMMUNOHISTOCHEMICAL EXPRESSION OF MONOCARBOXYLATE TRANSPORTER 1&4 IN TANYCYTE–LIKE CELLS OF THE SULCUS MEDIANUS ORGANUM." Iraqi Journal of Medical Sciences 17, no. 1 (2019): 83–99. http://dx.doi.org/10.22578/ijms.17.1.12.

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Background: Circumventricular organs (CVOs) are specialized structures border the brain ventricles and lack the blood-brain barrier. These CVOs are lined by specialized ependymal cells (ECs) called tanycyte. The sulcus medianus organum (SMO) locates at the floor of the 4th ventricle at the rostral part of the sulcus medianus (SM). Objective: To explore the expression of the monocarboxylate transporter 1 and monocarboxylate transporter 4 (MCT1 & MCT4) in the tanycytes of the median eminence (ME) and tanycyte-like cells of the SMO to add a functional evidence for describing the SMO as anothe
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de Seranno, Sandrine, Xavier d'Anglemont de Tassigny, Cecilia Estrella, et al. "Role of Estradiol in the Dynamic Control of Tanycyte Plasticity Mediated by Vascular Endothelial Cells in the Median Eminence." Endocrinology 151, no. 4 (2010): 1760–72. http://dx.doi.org/10.1210/en.2009-0870.

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In the ever-changing physiological context of the neuroendocrine brain, the mechanisms by which cellular events involving neurons, astroglia, and vascular cells are coordinated to bring forth the appropriate neuronal signaling is not yet known but is amenable to examination. In the median eminence of the hypothalamus, endothelial cells are key players in the plasticity of tanycytes (specialized astroglia) and neuroendocrine synapse efficacy. Here we report that estradiol acts on both purified endothelial cells and isolated tanycytes to trigger endothelial-to-glial communication that leads to a
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Bolborea, Matei, Gisela Helfer, Francis J. P. Ebling, and Perry Barrett. "Dual signal transduction pathways activated by TSH receptors in rat primary tanycyte cultures." Journal of Molecular Endocrinology 54, no. 3 (2015): 241–50. http://dx.doi.org/10.1530/jme-14-0298.

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Tanycytes play multiple roles in hypothalamic functions, including sensing peripheral nutrients and metabolic hormones, regulating neurosecretion and mediating seasonal cycles of reproduction and metabolic physiology. This last function reflects the expression of TSH receptors in tanycytes, which detect photoperiod-regulated changes in TSH secretion from the neighbouringpars tuberalis. The present overall aim was to determine the signal transduction pathway by which TSH signals in tanycytes. Expression of the TSH receptor in tanycytes of 10-day-old Sprague Dawley rats was observed byin situhyb
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Sánchez, Edith, Praful S. Singru, Gábor Wittmann та ін. "Contribution of TNF-α and Nuclear Factor-κB Signaling to Type 2 Iodothyronine Deiodinase Activation in the Mediobasal Hypothalamus after Lipopolysaccharide Administration". Endocrinology 151, № 8 (2010): 3827–35. http://dx.doi.org/10.1210/en.2010-0279.

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To determine whether signaling through TNF and/or nuclear factor-κB contributes to bacterial lipopolysaccharide (LPS)-induced activation of type 2 iodothyronine deiodinase (D2) in tanycytes lining the floor and infralateral walls of the third ventricle, the effect of a TNF antagonist on D2 gene expression and LPS-induced Iκ-Bα expression in tanycytes were studied. Animals treated with soluble, rat, polyethylene glycol-conjugated TNF receptor type 1 (4 mg/kg body weight) before a single ip injection of LPS showed a significant reduction in circulating IL-6 levels but no effect on LPS-induced D2
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Porniece Kumar, Marta, Anna Lena Cremer, Paul Klemm, et al. "Insulin signalling in tanycytes gates hypothalamic insulin uptake and regulation of AgRP neuron activity." Nature Metabolism 3, no. 12 (2021): 1662–79. http://dx.doi.org/10.1038/s42255-021-00499-0.

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AbstractInsulin acts on neurons and glial cells to regulate systemic glucose metabolism and feeding. However, the mechanisms of insulin access in discrete brain regions are incompletely defined. Here we show that insulin receptors in tanycytes, but not in brain endothelial cells, are required to regulate insulin access to the hypothalamic arcuate nucleus. Mice lacking insulin receptors in tanycytes (IR∆Tan mice) exhibit systemic insulin resistance, while displaying normal food intake and energy expenditure. Tanycytic insulin receptors are also necessary for the orexigenic effects of ghrelin, b
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Rafiei, Parisa, Huda S. Mian, Shruthi H. Iyer, et al. "In Preclinical Epilepsy, GLUT1 and GFAP Dysregulation in Cells Surrounding the Third Ventricle, Including Tanycytes, Is Differentially Restored with Ketogenic Diet Treatment." Nutrients 17, no. 11 (2025): 1824. https://doi.org/10.3390/nu17111824.

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Background/Objectives: Hyperexcitable neuronal activity associated with seizures may disrupt brain homeostasis resulting in abnormal glucose and nutrient management and metabolism. Specialized ependymal cells known as tanycytes line the third ventricle wall bridging communication between the brain, CSF, and blood. Despite their positional importance, whether tanycytes are impacted by epilepsy is unknown. Here, known protein markers of tanycytes were assessed in the Kcna1-null mouse model of genetic epilepsy with spontaneous recurrent seizures (SRS mice). Further, whether an anti-seizure metabo
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Dissertations / Theses on the topic "Tanyctes"

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Bellamy, Charlotte. "Functional characterization of a novel mutation in PRKCA, the major driver of Chordoid glioma." Electronic Thesis or Diss., université Paris-Saclay, 2024. http://www.theses.fr/2024UPASL052.

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Le gliome chordoïde (ChG) est une tumeur cérébrale rare de bas grade, caractérisée par une nouvelle mutation ponctuelle récurrente PRKCA p.D463H, une substitution dans le domaine kinase de la protéine kinase C alpha (PKCα). Cette étude démontre le rôle de cette kinase mutée dans le développement des ChG. Ici, nous montrons l'inactivation et l'effet négatif dominant de PKCαD463H via des tests d'activité in vitro et in cellulo. Nos résultats montrent que la mutation affecte la structure tertiaire, ce qui entraîne une protéine ouverte et instable. Les données de spectrométrie de masse phosphoprot
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Benford, Heather Elizabeth. "Signalling in hypothalamic tanycytes." Thesis, University of Warwick, 2014. http://wrap.warwick.ac.uk/62112/.

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Hypothalamic tanycytes are a specialised type of glial cell found lining the 3rd ventricle. They possess a cell body that contacts the cerebrospinal fluid (CSF) and a single long process that projects into the hypothalamic parenchyma, some of which are known to extend into the Arcuate nucleus (ARC) and Ventromedial nucleus (VMN), two key hypothalamic regions involved in control of energy homeostasis. Owing to their unique position, it has been hypothesised that hypothalamic tanycytes may be able to detect nutrient related signals in the CSF and influence the neurons of the ARC and VMN leading
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Lazutkaite, Greta. "Amino acid sensing in hypothalamic tanycytes via umami taste receptors." Thesis, University of Warwick, 2018. http://wrap.warwick.ac.uk/109627/.

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Energy homeostasis is controlled in the hypothalamus. Hypothalamic tanycytes are a type of glial cell that lie in the wall of the third ventricle, between ventricular CSF and the key nuclei controlling feeding, and are potentially linked to this regulation. Tanycytes have been found to express sweet taste receptors; similar receptors exist for amino acids and could be present in tanycytes. Therefore, the aims of this work were to understand the tanycyte amino acid signalling process, determine the impact of diet on tanycyte function, and link tanycytes to energy homeostasis. Using ratiometric
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Cappellini, Prieto Monica. "Transplantation de tanycytes dans la moelle épinière de rats adultes." Montpellier 2, 2000. http://www.theses.fr/2000MON20109.

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Il a ete recemment demontre que les tanycytes, type particulier de cellules gliales present dans l'hypothalamus mediobasal, favorisent la survie et la regeneration de nombreux types de neurones centraux. Dans cette etude, nous avons voulu utiliser ces proprietes particulieres des tanycytes afin de tenter de reparer la moelle epiniere lesee en fournissant un support favorable a la regeneration des neurones supraspinaux. Dans un premier temps, nous avons greffe des tanycytes soit dans la moelle epiniere intacte de rats adultes, soit dans la moelle epiniere lesee par compression. Cette etude nous
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Barbotin, Anne-Laure. "Plasticité neuro-structurale de l’hypothalamus dans le syndrome des ovaires polykystiques." Thesis, Lille, 2019. http://www.theses.fr/2019LILUS043.

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L’hormone anti-Müllerienne (AMH) dont les taux dans le sérum sont élevés dans le Syndrome des Ovaires Polykystiques (SOPK) est connue pour augmenter la sécrétion de LH/GnRH. Comme mis en évidence récemment, cette augmentation de la sécrétion de GnRH pourrait être liée à une hyperactivité des neurones à GnRH en réponse à une action directe de l’AMH mais pourrait également s’exercer indirectement via une augmentation des afférences excitatrices sur les neurones à GnRH. Par ailleurs, les tanycytes, qui enchâssent les terminaisons des neurones à GnRH, expriment le récepteur à l’AMH et sont connus
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Balland, Églantine. "Rôle des tanycytes de l’éminence médiane dans le transport de la leptine de la périphérie vers l’hypothalamus." Thesis, Lille 2, 2012. http://www.theses.fr/2012LIL2S053.

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Le noyau arqué hypothalamique (ARH) est un composant majeur des circuits neuronaux qui régulent la balance énergétique. Cependant les mécanismes d’entrée des hormones périphériques dans l’ARH sont peu connus. L’ARH est adjacent à l’éminence médiane (ME), où des cellules épendymales hautement spécialisées appelées tanycytes son tprésentes. Les corps cellulaires des tanycytes bordent le troisième ventricule et leurs prolongements basaux contactent le plexus de capillaires fenêtrés de la ME. Récemment, il a été proposé que les tanycytes joueraient un rôle dans la régulation de la barrière sang hy
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Mullier, Amandine. "Etude des interfaces sang/cerveau dans la région tubérale de l'hypothalamus médiobasal: rôle des tanycytes de l'éminence médiane." Phd thesis, Université du Droit et de la Santé - Lille II, 2009. http://tel.archives-ouvertes.fr/tel-00515862.

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L'hypothalamus joue un rôle critique dans la régulation des systèmes physiologiques et de l'homéostasie. Il relaie au niveau central les signaux ou hormones sécrétées en périphérie. L'intégration de ces signaux s'effectue au niveau des interfaces sang/cerveau. Trois grandes interfaces sang/cerveau sont décrites au niveau central : la barrière hémato-encéphalique, les plexus choroïdes et les organes circumventriculaires. Alors que les deux premières sont bien caractérisées, les organes circumventriculaires sont mal connus. La région tubérale de l'hypothalamus médiobasal est une région cérébrale
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Chauvet, Norbert. "Rôles des tanycytes dans les mécanismes de régénération axonale des neurones du système nerveux central du rat adulte." Montpellier 2, 1997. http://www.theses.fr/1997MON20160.

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Dans le systeme nerveux central des vertebres superieurs adultes, la regeneration axonale est extremement limitee. Cependant, il est connu que les neurones de l'hypothalamus mediobasal sont capables de regenerer. Ce travail a donc ete entrepris afin de comprendre les raisons d'une telle reponse postlesionnelle des neurones hypothalamiques. Les travaux realises sur l'hypothalamus ont permis de mettre en evidence par des approches morphologiques des associations preferentielles entre les axones qui regenerent et les prolongements d'un type particulier de cellules gliales present dans l'hypothala
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Chaker, Zayna. "Longevity gene IGF-1 and adult neurogenesis : regulation of lifelong neuronal replacement, olfactory function and metabolism." Thesis, Paris 5, 2014. http://www.theses.fr/2014PA05T052.

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Pas de résumé<br>Production of new neurons in the brain decreases dramatically with age due to progressive physiological depletion of stem and progenitor cell populations (NSCs). Recent studies indicate that circulating factors constitute a systemic aging milieu regulating the birth of new cells. Interestingly, some long-lived mouse strains such as Ames dwarf mutants, with low circulating levels of GH and IGF-1, show increased neurogenesis and preserved hematopoietic stem cell pool. Thus, the possibility that genes regulating lifespan and aging also quantitatively modulate stem cells in mammal
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Milesi, Sébastien. "Rôle de la signalisation hypothalamique TSH/T3 dans la reproduction saisonnière chez les hamsters Djungariens (Phodopus sungorus) et Syriens (Mesocricetus auratus)." Thesis, Strasbourg, 2018. http://www.theses.fr/2018STRAJ023/document.

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Chez les hamsters, les jours longs activent la reproduction. Cette activation photopériodique (AP) impliquerait la mélatonine, l’hormone thyroïdienne (HT) et les RFamides hypothalamiques. Si les jours courts inhibiteurs sont maintenus au-delà de 20 semaines, une réactivation photoréfractaire (RP) de l’axe hypothalamo pituitaire gonadotrope (HPG) est déclenchée. Les mécanismes de cette RP sont inconnus. Notre analyse de la cinétique des changements moléculaires induits par l’AP et la RP montre dans les deux cas une inhibition précoce de l’expression de la Désiodinase 3 (Dio3), l’enzyme cataboli
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Book chapters on the topic "Tanyctes"

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Lechan, Ronald M., and Csaba Fekete. "Tanycyte Regulation of Hypophysiotropic TRH Neurons." In Masterclass in Neuroendocrinology. Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-62383-8_12.

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Barrett, Perry, and Peter J. Morgan. "Tanycytes and Their Pivotal Role in Seasonal Physiological Adaptations." In Neuroendocrine Clocks and Calendars. Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-55643-3_3.

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Nampoothiri, Sreekala, Manon Duquenne, and Vincent Prevot. "Unveiling the Importance of Tanycytes in the Control of the Dialogue Between the Brain and the Periphery." In Masterclass in Neuroendocrinology. Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-62383-8_11.

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Blackshaw, Seth, Daniel A. Lee, Thomas Pak, and Sooyeon Yoo. "Regulation of Body Weight and Metabolism by Tanycyte-Derived Neurogenesis in Young Adult Mice." In Stem Cells in Neuroendocrinology. Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-41603-8_5.

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Hökfelt, T., G. Foster, M. Schultzberg, et al. "DARPP-32 as a Marker for D-1 Dopaminoceptive Cells in the Rat Brain: Prenatal Development and Presence in Glial Elements (Tanycytes) in the Basal Hypothalamus." In Advances in Experimental Medicine and Biology. Springer US, 1988. http://dx.doi.org/10.1007/978-1-4899-2723-1_6.

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Flament-Durand, J., and J. P. Brion. "Tanycytes: Morphology and Functions: A Review." In International Review of Cytology. Elsevier, 1985. http://dx.doi.org/10.1016/s0074-7696(08)60596-3.

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Bernal, Juan. "Deiodinases in the Brain." In Thyroid and Brain: Understanding the Actions of Thyroid Hormones in Brain Development and Function. BENTHAM SCIENCE PUBLISHERS, 2024. http://dx.doi.org/10.2174/9789815274226124010007.

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Deiodinases (DIO) are central to regulating thyroid hormone action in the brain because they control the tissue concentration of the active hormone triiodothyronine (T3). DIO2, the outer ring, 5’-deiodinase expressed in the brain, converts T4 to T3 and is active primarily in two glial cell types: astrocytes and tanycytes. Astrocytes produce all of brain T3 during the fetal period and a significant fraction in adults. T3 from astrocytes reaches other neural cells, mainly neurons, devoid of DIO2. The T3 produced in the tanycytes travels to hypothalamic nuclei to perform neuroendocrine functions.
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RAFOLS, JOSÉ A. "EPENDYMAL TANYCYTES OF THE VENTRICULAR SYSTEM IN VERTEBRATES." In Astrocytes. Elsevier, 1986. http://dx.doi.org/10.1016/b978-0-12-250451-8.50009-6.

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Iyer, Lakshmanan K., Joshua A. Ainsley, Csaba Fekete, and Ronald M. Lechan. "Digital Expression Profiling of Tanycytes Suggests Molecular Mechanisms for Their Biological Function." In BASIC/TRANSLATIONAL - Pituitary Biology & Tumorigenesis. The Endocrine Society, 2011. http://dx.doi.org/10.1210/endo-meetings.2011.part2.p2.p1-396.

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Prevot, Vincent, Ruben Nogueiras, and Markus Schwaninger. "Tanycytes in the infundibular nucleus and median eminence and their role in the blood–brain barrier." In The Human Hypothalamus - Middle and Posterior Region. Elsevier, 2021. http://dx.doi.org/10.1016/b978-0-12-820107-7.00016-1.

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