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Journal articles on the topic 'Taraxasterol'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Reynolds, William F., Jeffery F. Sawyer, Raúl G. Enriquez, Laura I. Escobar, Marco A. Chavez, and James N. Shoolery. "Total assignment of the 13C spectrum of taraxasteryl acetate by 13C–13C connectivity experiments and determination of the stereochemistry of taraxasterol by X-ray diffraction." Canadian Journal of Chemistry 63, no. 5 (1985): 1048–54. http://dx.doi.org/10.1139/v85-178.

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13C–13C connectivity (INADEQUATE) experiments have been used to reassign the 13C spectrum of taraxasteryl acetate. This shows that there were ten errors in an earlier 13C spectral assignment for this compound. An X-ray diffraction investigation of taraxasterol shows that ring E adopts a slightly distorted boat conformation. It is suggested that severe steric interactions in the chair form force it to adopt this unusual conformation. On the basis of the 1H–1H coupling constants, it is concluded that taraxasteryl acetate adopts a very similar conformation in solution. Crystals of taraxasterol–et

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2

Wang, Shuquan, and Xuhui Tang. "Protective Effect of Taraxasterol Against Myocardial Damage Caused by Sepsis Through Inhibition of Toll-Like Receptor 4/Nuclear Factor-Kappa B Signaling Pathway." Current Topics in Nutraceutical Research 19, no. 3 (2021): 339–44. http://dx.doi.org/10.37290/ctnr2641-452x.19:339-344.

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Taraxasterol exerts protective effects against vascular or neuroinflammation and hepatic injury. However, its role on myocardial damage caused by sepsis has not been thoroughly investigated. Myocardial tissues of septic rats - established by cecal ligation and puncture - show a disordered myocardial fiber arrangement, edema, nuclear membrane rupture, and inflammatory cell infiltration. Administration of taraxasterol to these rats attenuated the morphological changes in the myocardial tissues. Biomarkers of cardiac injury in sepsis such as cardiac troponin I, creatine kinase-MB, and lactic acid

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3

Wang, Junxiong, Kexin Zheng, Yongcheng Jin, Yurong Fu, Rui Wang, and Jing Zhang. "Protective Effects of Taraxasterol against Deoxynivalenol-Induced Damage to Bovine Mammary Epithelial Cells." Toxins 14, no. 3 (2022): 211. http://dx.doi.org/10.3390/toxins14030211.

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Deoxynivalenol (DON), a mycotoxin produced by Fusarium graminearum, is one of the most prevalent contaminants in livestock feed and causes very large losses to animal husbandry every year. Taraxasterol, isolated from Taraxacum officinale, has anti-inflammatory, antioxidative stress, and antitumor effects. In the present study, bovine mammary epithelial cells (MAC-T) were used as a model, and different concentrations of taraxasterol (0, 1, 5, 10, and 20 μg/mL) were used to protect against DON-induced cell damage. The results showed that taraxasterol at a concentration of 10 μg/mL significantly

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4

Hemmers, Herbert, Paul-Gerhard Gülz, and Franz-Josef Marner. "Tetra-and Pentacyclic Triterpenoids from Epicuticular Wax of Euphorbia cyparissias L., Euphorbiaceae." Zeitschrift für Naturforschung C 44, no. 7-8 (1989): 563–67. http://dx.doi.org/10.1515/znc-1989-7-804.

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Abstract The epicuticular wax of Euphorbia cyparissias contains pentacyclic triterpenoids (34%) and primary alcohols (31%) as major com ponents. The major triterpenoids are triterpenols (23%) consisting of α-and β-amyrin, glutinol, 24-m ethylenecycloartenol and ψ-taraxasterol. The triter penones (10.5%) are com posed of taraxerone. a -and β-amyrinone, lupenone, glutinone, ψ-taraxasterone, β-fernenone and three further unidentified triterpenes. α-Amyrin was found esterified with hom ologous series of fatty acids. Minor components are alkanes, wax esters, aldehydes and free fatty acids.

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5

Xu, Lu, Yifan Yu, Rui Sang, Jinxia Li, Bingjie Ge та Xuemei Zhang. "Protective Effects of Taraxasterol against Ethanol-Induced Liver Injury by Regulating CYP2E1/Nrf2/HO-1 and NF-κB Signaling Pathways in Mice". Oxidative Medicine and Cellular Longevity 2018 (23 вересня 2018): 1–11. http://dx.doi.org/10.1155/2018/8284107.

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Taraxasterol, a pentacyclic-triterpene compound, is one of the main active components isolated from the traditional Chinese medicinal herb Taraxacum. The objective of this study is to evaluate the protective effects of taraxasterol and its possible underlying mechanisms against ethanol-induced liver injury in mice. ICR mice were fed with Lieber-DeCarli diet containing 5% ethanol for 10 d and then challenged with a single dose of 20% ethanol (5 g/kg BW) by intragastric administration. The mice were intragastrically treated daily with taraxasterol (2.5, 5, and 10 mg/kg). Tiopronin was used as a

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6

Han, Jung Yeon, Hye-Jeong Jo, Eun Kyung Kwon, and Yong Eui Choi. "Cloning and Characterization of Oxidosqualene Cyclases Involved in Taraxasterol, Taraxerol and Bauerenol Triterpene Biosynthesis in Taraxacum coreanum." Plant and Cell Physiology 60, no. 7 (2019): 1595–603. http://dx.doi.org/10.1093/pcp/pcz062.

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Abstract Triterpenes, consisting of six isoprene units, are one of the largest classes of natural compounds in plants. The genus Taraxacum is in the family Asteraceae and is widely distributed in the Northern Hemisphere. Various triterpenes, especially taraxerol and taraxasterol, are present in Taraxacum plants. Triterpene biosynthesis occurs through the action of oxidosqualene cyclase (OSC), which generates various types of triterpenes from 2,3-oxidosqualene after the rearrangement of the triterpene skeleton. However, no functional characterization of the OSC genes involved in triterpene bios

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7

Yang, Kerry, and Yanjie Zhang. "Reversal of heavy metal-induced antibiotic resistance by dandelion root extracts and taraxasterol." Journal of Medical Microbiology 69, no. 8 (2020): 1049–61. http://dx.doi.org/10.1099/jmm.0.001226.

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Introduction. Metal exposure is an important factor for inducing antibiotic resistance in bacteria. Dandelion extracts have been used for centuries in traditional Chinese and Native American medicine. Aim. We assessed the effects of dandelion water extracts and taraxasterol on heavy metal-induced antibiotic resistance in Escherichia coli as well as the underlying mechanisms. Methodology. Dandelion extracts were obtained through 4 h of boiling in distilled water. Bacterial growth was monitored with a spectrophotometer. Biochemical assays were performed to assess the activities and gene transcri

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8

Obafemi, Olabisi Tajudeen, Ademola Olabode Ayeleso, Blessing Ariyo Obafemi, et al. "Pharmacological relevance of taraxasterol: A review." Pharmacological Research - Modern Chinese Medicine 13 (December 2024): 100533. http://dx.doi.org/10.1016/j.prmcm.2024.100533.

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9

Boğa, Mehmet, Pelin Köseoğlu Yılmaz, Deniz Barıș Cebe, Mashhad Fatima, Bina S. Siddiqui, and Ufuk Kolak. "Chemical Constituents and Biological Activities of Cirsium leucopsis, C. sipyleum, and C. eriophorum." Zeitschrift für Naturforschung C 69, no. 9-10 (2014): 381–90. http://dx.doi.org/10.5560/znc.2014-0071.

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Abstract Two endemic Cirsium species, C. leucopsis DC. and C. sipyleum O. Schwarz, and C. eriophorum (L.) Scop. growing in Turkey were investigated to establish their secondary metabolites, fatty acid compositions, and antioxidant and anticholinesterase potentials. Spectroscopic methods were used to elucidate the structures of thirteen known compounds (p-hydroxy-benzoic acid, vanillic acid, cisepoxyconiferyl alcohol, syringin, balanophonin, 1′-O-methyl-balanophonin, apigenin, kaempferol-3- O-β-D-glucopyranoside, kaempferol-3-O-α-L-rhamnopyranoside, taraxasterol, taraxasterol acetate, β-sitoste

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10

Wu, Jianhao, Jialin Sun, Meiqi Liu, et al. "Botany, Traditional Use, Phytochemistry, Pharmacology and Quality Control of Taraxaci herba: Comprehensive Review." Pharmaceuticals 17, no. 9 (2024): 1113. http://dx.doi.org/10.3390/ph17091113.

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Taraxaci herba, as a traditional Chinese medicine, is the name of the Taraxacum genus in the Asteraceae family. Documented in the Tang Herbal Medicine (Tang Dynasty, AD 657–659), its medicinal properties cover a wide range of applications such as acute mastitis, lung abscess, conjunctival congestion, sore throat, damp-heat jaundice, and vision improvement. In the Chinese Pharmacopoeia (Edition 2020), more than 40 kinds of China-patented drugs containing Taraxaci herba were recorded. This review explores the evolving scientific understanding of Taraxaci herba, covering facets of ethnopharmacolo

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11

Zafar, Rasheeduz, and Kiran Sharma. "Occurrence of taraxerol and taraxasterol in medicinal plants." Pharmacognosy Reviews 9, no. 17 (2015): 19. http://dx.doi.org/10.4103/0973-7847.156317.

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12

Trendafilova, Antoaneta, Victoria Ivanova, Milka Todorova, Plamena Staleva, and Ina Aneva. "Terpenoids in four Inula species from Bulgaria." Journal of the Serbian Chemical Society 86, no. 12 (2021): 1229–40. http://dx.doi.org/10.2298/jsc210730087t.

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Phytochemical study of the chloroform extract of the aerial parts of Inula germanica L., I. ensifolia L., I. conyza (Griess.) DC. and I. salicina L. led to the identification of 33 terpenoids. ?- and ?-amyrin, lupeol, taraxasterol, ?-taraxasterol and their 3-O-acetates and 3-O-palmitates were identified by GC/MS. In addition, the structures of 3-O-palmitates of mainaladiol, arnidiol, faradiol and 16-hydroxylupeol were confirmed by NMR. ent-Kaur-16-en-19- -oic acid and its 15?-(3-methylpentanoyloxy) and 15?-(3-methylbutanoyloxy) derivatives were isolated from I. conyza. Ten closely related sesq

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13

Petrović, S. D., M. S. Gorunović, V. Wray, and I. Merfort. "A taraxasterol derivative and phenolic compounds from Hieracium gymnocephalum." Phytochemistry 50, no. 2 (1999): 293–96. http://dx.doi.org/10.1016/s0031-9422(98)00536-6.

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14

Yang, Ai Mei, Wei Jie Guo, Yan Zeng, Hong Fei Gong, and Rui Wu. "Chemical Constituents from Cremanthodium potaninii." Advanced Materials Research 852 (January 2014): 8–11. http://dx.doi.org/10.4028/www.scientific.net/amr.852.8.

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Ten compounds were isolated from the ethol extract of the whole plant of Cremanthodium potaninii. Stigmasterol (1), β-sitosterol (2), triacontane (3), 5,6-dihydroxy-3,4,7-trimethoxyflavone (4), 5,6,7-trihydroxy-3,4-dimethoxyflavone (5), 6-hydroxy-7-methoxycoumarin (6), taraxasterol (7), caffeic acid (8),hexacosoic acid (9),triacontanoic acid (10). All these compounds were isolated from Cremanthodium potaninii for the first time.

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15

Trendafilova, Antoaneta, Milka Todorova, Nikolina Kutova, and Maya Guncheva. "Phytochemical Profile and Anti-lipase Activity of Balkan Endemic Jurinea tzar-ferdinandii." Natural Product Communications 13, no. 8 (2018): 1934578X1801300. http://dx.doi.org/10.1177/1934578x1801300823.

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Phytochemical study of the Balkan endemic J. tzar-ferdinandii Davidov allowed the identification of twenty-two components. β-Amyrin, lupeol, taraxasterol and Ψ-taraxasterol and their 3- O-acetates and 3- O-palmitates were identified by GC/MS. Six closely related sesquiterpene lactones and four flavones were isolated from the chloroform extract using column chromatography, and their structural identification was performed by spectral analyses. All isolated compounds are described for the first time in Jurinea species. The inhibitory potential of the total chloroform extract, fractions containin

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16

Mitova, Maya, Rilka Taskova, Simeon Popov, Ralf Günter Berger, Ulrich Krings, and Nedjalka Handjieva. "GC/MS Analysis of Some Bioactive Constituents from Carthamus lanatus L." Zeitschrift für Naturforschung C 58, no. 9-10 (2003): 697–703. http://dx.doi.org/10.1515/znc-2003-9-1018.

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AbstractSterols, triterpenes, volatiles, polar and other constituents in aerial parts of Carthamus lanatus were analyzed by gas chromatography-mass spectrometry. Over 90 compounds were identified most of them new for the species. Sitosterol and stigmasterol were the most abundant of 10 sterols identified in the sterol fraction. Taraxasterol, α- and β-amyrine prevailed in the triterpene fraction. Volatiles, sterols and a fraction of the dichloromethane extract showed strong cytotoxicity (Artemia salina assay).

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17

Wang, Ying, Guan-Hao Li, Xin-Yu Liu, Lu Xu, Sha-Sha Wang, and Xue-Mei Zhang. "IN VIVO ANTI-INFLAMMATORY EFFECTS OF TARAXASTEROL AGAINST ANIMAL MODELS." African Journal of Traditional, Complementary and Alternative medicines 14, no. 1 (2016): 43–51. http://dx.doi.org/10.21010/ajtcam.v14i1.6.

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18

Onal Sis, Cagil, Yagmur Okcay, Kemal Gokhan Ulusoy, Ismail Mert Vural, and Oguzhan Yıldız. "Exploring the antinociceptive effect of taraxasterol in mice: Possible mechanisms." Neuroscience Letters 845 (January 2025): 138075. https://doi.org/10.1016/j.neulet.2024.138075.

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19

Liu, Jingtao, Huanzhang Xiong, Yao Cheng, et al. "Effects of taraxasterol on ovalbumin-induced allergic asthma in mice." Journal of Ethnopharmacology 148, no. 3 (2013): 787–93. http://dx.doi.org/10.1016/j.jep.2013.05.006.

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20

Shakurova, É. R., T. I. Parfenova, R. Sh Sufiyarova, A. Z. Khalilova, V. R. Akhmetova, and S. A. Bashkatov. "Synthesis and anti-inflammatory activity of acyl derivatives of taraxasterol." Pharmaceutical Chemistry Journal 42, no. 6 (2008): 319–21. http://dx.doi.org/10.1007/s11094-008-0116-8.

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21

Movahhed, Morteza, Mona pazhouhi, HadiEsmaeili Gouvarchin Ghaleh, and BahmanJalali Kondori. "Anti-metastatic effect of taraxasterol on prostate cancer cell lines." Research in Pharmaceutical Sciences 18, no. 4 (2023): 439. http://dx.doi.org/10.4103/1735-5362.378090.

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22

Walter, Angelika, and Urs Séquin. "Surface Lipids Isolated from the Leaves of <i>Boscia salicifolia</i> Oliv." CHIMIA 43, no. 11 (1989): 353. https://doi.org/10.2533/chimia.1989.353.

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The surface lipids of the leaves of Boscia salicifolia Oliv. were investigated by means of gas chromatography/mass spectrometry. The hydrocarbon fraction contained n-alkanes (n-C20H42 to n-C33H68) with heptacosane as the main component. Octacosanol proved to be the major constituent of the fraction of the primary n-alcohols; the aldehyde fraction consisted of saturated n-aldehydes, octacosanal being the main compound here. Furthermore, the phytosterols lupeol, taraxasterol, stigmasterol, and β-sitosterol were isolated.

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23

Zhang, Yu, Ramizu Bin Shaari, Mohamad Arif Bin Awang Nawi, Akram Bin Hassan, and Caiyun Cui. "Taraxasterol protects osteoblasts from high glucose by regulating ERK 1/2." ScienceAsia 50, no. 4 (2024): 1. http://dx.doi.org/10.2306/scienceasia1513-1874.2024.081.

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24

Piao, Taikui, Zhiqiang Ma, Xin Li та Jianyu Liu. "Taraxasterol inhibits IL-1β-induced inflammatory response in human osteoarthritic chondrocytes". European Journal of Pharmacology 756 (червень 2015): 38–42. http://dx.doi.org/10.1016/j.ejphar.2015.03.012.

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25

He, Haiyan, Baoling Xu, Pengfei Ge, et al. "The effects of taraxasterol on liver fibrosis revealed by RNA sequencing." International Immunopharmacology 114 (January 2023): 109481. http://dx.doi.org/10.1016/j.intimp.2022.109481.

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26

Babaamer, Zohra Y., Lakhdar Sakhri, Hala I. Al-Jaber, Mahmoud A. Al-Qudah, and Musa H. Abu Zarga. "Two new taraxasterol-type triterpenes from Pergularia tomentosa growing wild in Algeria." Journal of Asian Natural Products Research 14, no. 12 (2012): 1137–43. http://dx.doi.org/10.1080/10286020.2012.733700.

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27

Zhang, Xuemei, Huanzhang Xiong, and Liben Liu. "Effects of taraxasterol on inflammatory responses in lipopolysaccharide-induced RAW 264.7 macrophages." Journal of Ethnopharmacology 141, no. 1 (2012): 206–11. http://dx.doi.org/10.1016/j.jep.2012.02.020.

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28

Bao, Tianhao, Yang Ke, Yifan Wang, et al. "Taraxasterol suppresses the growth of human liver cancer by upregulating Hint1 expression." Journal of Molecular Medicine 96, no. 7 (2018): 661–72. http://dx.doi.org/10.1007/s00109-018-1652-7.

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29

Mahmud, Shafi, Suvro Biswas, Gobindo Kumar Paul, et al. "Plant-Based Phytochemical Screening by Targeting Main Protease of SARS-CoV-2 to Design Effective Potent Inhibitors." Biology 10, no. 7 (2021): 589. http://dx.doi.org/10.3390/biology10070589.

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Currently, a worldwide pandemic has been declared in response to the spread of coronavirus disease 2019 (COVID-19), a fatal and fast-spreading viral infection caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The low availability of efficient vaccines and treatment options has resulted in a high mortality rate, bringing the world economy to its knees. Thus, mechanistic investigations of drugs capable of counteracting this disease are in high demand. The main protease (Mpro) expressed by SARS-CoV-2 has been targeted for the development of potential drug candidates due to t

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30

Jain, S. C., R. Jain, R. Singh, and E. Menghani. "CHEMICAL INVESTIGATION AND BIOLOGICAL ACTIVITIES OF VERBESINA ENCELIOIDES." INDIAN DRUGS 49, no. 01 (2012): 38–42. http://dx.doi.org/10.53879/id.49.01.p0038.

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From the petroleum ether extract of flowers, betulin, friedelin and lupeol were isolated for the first time along with six other known compounds viz. n-triacontane, ester of beta-sitosterol, tricosyl alcohol, taraxasterol, beta-amyrin etc. During antibacterial screening, water extract of seeds showed appreciable activity (IZ 12 mm) against Pseudomonas aeruginosa. Similarly, in antifungal screening, chloroform extract of flowers (IZ 30 mm) and alcohol extract of roots (IZ 29 mm) exhibited very pronounced inhibitory activity against Tricophyton rubrum. High degree of free radical scavenging acti

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31

Xu, Chen, Hai-Yang Jia, Bo Zuo, et al. "Chemical Constituents of the Aerial Parts of Euphorbia Nematocypha." Natural Product Communications 11, no. 2 (2016): 1934578X1601100. http://dx.doi.org/10.1177/1934578x1601100210.

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Chemical constituents of the dried aerial parts of Euphorbia nematocypha were investigated. A new oleanane triterpenoid, trans, trans-2′,4′-hexadienedioicacid-1′-β-amyrin ester (1), together with, β-amyrin (2), β-amyrin acetate (3), betulinic acid (4), ellagic acid (5), oleanolic acid (6), β-sitosterol (7), kaempferol (8), quercetin (9), lupeol (10) and pseudo-taraxasterol (11) were isolated from the methylene chloride extract. Their structures were elucidated on the basis of extensive spectroscopic (1D- & 2D-NMR) and ESI-MS analysis and comparison with data reported in the literature. The

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32

Hemmers, Herbert, Paul-Gerhard Gülz, Franz-Josef Marner, and Victor Wray. "Pentacyclic Triterpenoids in Epicuticular Waxes from Euphorbia lathyris L., Euphorbiaceae." Zeitschrift für Naturforschung C 44, no. 3-4 (1989): 193–201. http://dx.doi.org/10.1515/znc-1989-3-404.

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Abstract The chemical composition of the leaf surface wax of Euphorbia lathyris L. was analysed using TLC, GC, GC-MS and NMR. A predominance of pentacyclic triterpenoids and primary alcohols was observed. They together constituted 60% of the total wax. Seven triterpenols: taraxerol, β-amyrin, lupeol, isomotiol, a-fernenol, simiarenol. Ψ-taraxasterol and eight triterpenones: taraxerone, β-amyrinone, lupenone, isomotione, a- and β-fernenone, simiarenone and filicanone were isolated. Among them , β-amyrin and lupeol were found esterified with homologous series of fatty acids. The minor part of wa

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33

Zhang, Yuzhi, Hao Fu, Yongtao Zhang та ін. "Taraxasterol repairs UVB-induced skin barrier injury through MAPK/NF-κB signaling pathways". Food and Agricultural Immunology 33, № 1 (2022): 604–16. http://dx.doi.org/10.1080/09540105.2022.2107619.

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34

Chen, Wei, Jingwei Li, Chen Li, Hui-Ning Fan, Jing Zhang, and Jin-Shui Zhu. "Network pharmacology-based identification of the antitumor effects of taraxasterol in gastric cancer." International Journal of Immunopathology and Pharmacology 34 (January 2020): 205873842093310. http://dx.doi.org/10.1177/2058738420933107.

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Taraxasterol (TAX), a pentacyclic triterpene, has been reported to exhibit potent antitumor activity. However, the effects and molecular mechanisms of TAX in gastric cancer (GC) remain undocumented. A network pharmacology approach was applied to identify the collective targets of TAX and GC. Nude mice were subcutaneously injected with MKN-28 cells to establish GC subcutaneous xenograft model, which were treated with TAX for 16 days. Tumor volume was then examined every other day. The pathological scoring was assessed by using hematoxylin and eosin (H&E) staining, and the expression levels

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35

San, Zhihao, Yunhe Fu, Wei Li, et al. "Protective effect of taraxasterol on acute lung injury induced by lipopolysaccharide in mice." International Immunopharmacology 19, no. 2 (2014): 342–50. http://dx.doi.org/10.1016/j.intimp.2014.01.031.

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36

Chen, Wei, Wei Da, Chen Li, et al. "Network pharmacology-based identification of the protective mechanisms of taraxasterol in experimental colitis." International Immunopharmacology 71 (June 2019): 259–66. http://dx.doi.org/10.1016/j.intimp.2019.03.042.

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37

Zheng, Feng, Xiaomeng Dong, and Xiangzhu Meng. "Anti-Inflammatory Effects of Taraxasterol on LPS-Stimulated Human Umbilical Vein Endothelial Cells." Inflammation 41, no. 5 (2018): 1755–61. http://dx.doi.org/10.1007/s10753-018-0818-3.

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38

Sing, Bupinder, S. N. Ram, V. B. Pandey, V. K. Joshi, and S. S. Gambhir. "Studies on antiinflammatory activity of taraxasterol acetate fromEchinops echinatus in rats and mice." Phytotherapy Research 5, no. 3 (1991): 103–6. http://dx.doi.org/10.1002/ptr.2650050303.

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39

Lee, Hsiu-Pu Daniel, Larry S. Eichmeier, and David M. Piatak. "Mass spectral study of ringE of taraxasterol and compounds with similar ring substitution." Organic Mass Spectrometry 20, no. 3 (1985): 247–52. http://dx.doi.org/10.1002/oms.1210200315.

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40

Han, Anna, Jiajing Liu, Pan Du, et al. "Taraxasterol regulates p53 transcriptional activity to inhibit pancreatic cancer by inducing MDM2 ubiquitination degradation." Phytomedicine 136 (January 2025): 156298. https://doi.org/10.1016/j.phymed.2024.156298.

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41

Xie, Jianlong. "Taraxasterol exhibits dual biological effects on anti-aging and anti-cancer in lung cells." American Journal of Cancer Research 14, no. 6 (2024): 2755–69. http://dx.doi.org/10.62347/yltr8866.

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42

Yousefi Ghale-Salimi, Mahboubeh, Maryam Eidi, Nasser Ghaemi, and Ramezan Ali Khavari-Nejad. "Antiurolithiatic effect of the taraxasterol on ethylene glycol induced kidney calculi in male rats." Urolithiasis 46, no. 5 (2017): 419–28. http://dx.doi.org/10.1007/s00240-017-1023-9.

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43

Li, Guangzhi, Dongmei Zhang, Shizhen Wang, Ni Jie, and Yongting Qin. "Protective Role of Taraxasterol against Cardiovascular Aging and Aging-Induced Desensitization of Insulin Signaling." Frontiers in Bioscience-Landmark 27, no. 11 (2022): 311. http://dx.doi.org/10.31083/j.fbl2711311.

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44

Wang, Shasha, Ying Wang, Xinyu Liu, Lizeng Guan, Longzheng Yu, and Xuemei Zhang. "Anti-inflammatory and anti-arthritic effects of taraxasterol on adjuvant-induced arthritis in rats." Journal of Ethnopharmacology 187 (July 2016): 42–48. http://dx.doi.org/10.1016/j.jep.2016.04.031.

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Zhao, Mao, Mingxing Lu, Yongjiang Zeng, et al. "Taraxasterol Inhibits Hepatic Gluconeogenesis and Increases Glycogen Synthesis via the PI3K/Akt Signaling Pathway." Natural Product Communications 18, no. 3 (2023): 1934578X2311540. http://dx.doi.org/10.1177/1934578x231154068.

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Objective: Taraxasterol (TS) is the main active compound of Taraxacum, which plays a significant role in the treatment of diabetes in many classic prescriptions. However, the mechanisms of TS in the treatment of diabetes remain unclear. This study aimed to investigate the underlying mechanism of TS in hepatic gluconeogenesis and glycogen synthesis in HepG2 cells with insulin resistance (IR). Methods: Molecular docking was conducted by using Discovery Studio (DS) to predict the target of TS in the treatment of diabetes. Then we treated HepG2 cells with glucosamine for 18 h. After the cells were

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Liu, Jianing, Hailing Yang, Ran Liu, et al. "Investigation of the Anti-Lung Cancer Mechanisms of Taraxacum officinale Based on Network Pharmacology and Multidimensional Experimental Validation." Pharmaceuticals 18, no. 5 (2025): 663. https://doi.org/10.3390/ph18050663.

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Background:Taraxacum officinale(commonly known as dandelion) is a medicinal and edible plant, with the entire plant being used for therapeutic purposes. Studies have demonstrated that dandelion exhibits inhibitory effects against various types of cancer. However, research on its potential for lung cancer (LC) treatment is limited, and the specific compounds responsible for its anticancer effects, as well as the underlying mechanisms, remain unclear. Methods: This study aimed to elucidate the underlying pharmacological mechanisms by which dandelion exerts therapeutic effects against LC. Initial

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Jiang, Shu-Hua, Li-Feng Ping, Feng-Yan Sun, Xiao-Lei Wang, and Zhi-Juan Sun. "Protective effect of taraxasterol against rheumatoid arthritis by the modulation of inflammatory responses in mice." Experimental and Therapeutic Medicine 12, no. 6 (2016): 4035–40. http://dx.doi.org/10.3892/etm.2016.3860.

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Liu, Wenfang, Qianying Yu, Fei Wang, Yunxia Li, Guohua Zhang, and Sirui Tao. "Taraxasterol attenuates melanoma progression via inactivation of reactive oxygen species-mediated PI3K/Akt signaling pathway." Human & Experimental Toxicology 41 (January 2022): 096032712110690. http://dx.doi.org/10.1177/09603271211069034.

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Background: Taraxasterol (TX), a pentacyclic triterpene, is one of the main active constituents isolated from Taraxacum officinale. A growing number of studies have reported that TX exhibits a wide range of biological activities such as anti-oxidative, anti-inflammatory, and neuro-protective effects. Recently, TX has been demonstrated to be a potential drug candidate for treatment of some types of cancers. However, the specific role of TX in melanoma remains unclear. Purpose: In this study, we aimed at exploration of the effect of TX on melanoma cell viability, apoptosis, migration, invasion,

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Zhang, Xuemei, Huanzhang Xiong, Hongyu Li, and Yao Cheng. "Protective effect of taraxasterol against LPS-induced endotoxic shock by modulating inflammatory responses in mice." Immunopharmacology and Immunotoxicology 36, no. 1 (2013): 11–16. http://dx.doi.org/10.3109/08923973.2013.861482.

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Wu, H. K., X. L. Xin, Z. Su, and H. A. Aisa. "2-Isopropyl-6-methylpyrimidin-4(3H)-one and taraxasterol from the stems of Cichorium glandulosum." Chemistry of Natural Compounds 47, no. 4 (2011): 664–66. http://dx.doi.org/10.1007/s10600-011-0027-x.

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