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Dissertations / Theses on the topic 'Target differentiation'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Ferguson, Charmaine. "Development of an in vitro model of neuronal differentiation and nerve-target interaction." Thesis, University of Ottawa (Canada), 2006. http://hdl.handle.net/10393/27356.

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My objective was to develop a nerve source for use in a 3-dimensional in vitro model to study neurite extension and target innervation. A hybrid neuroblastoma-DRG cell line (ND-C) with properties of neuronal precursors was examined for its ability to effectively differentiate into neurons, produce extensive neurites, and interact with target cells. Neuronal differentiation of ND-Cs was optimized through a combinatorial approach that involved culturing the cells in the presence of various types of culture media, ECM, and soluble factors in a dose dependent fashion. The proportion of neurons an

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2

Raif, Anna Women's &amp Children's Health Faculty of Medicine UNSW. "Neuroblastoma tumorigenesis: arrested differentiation as a mechanism of disease, and a treatment target." Publisher:University of New South Wales. Women's & Children's Health, 2009. http://handle.unsw.edu.au/1959.4/43639.

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The molecular mechanisms of neuroblastoma tumorigenesis include arrested neuritic differentiation, making an attractive strategy for treatments which promote differentiation of this childhood disease. The N-Myc oncoprotein has an established role in neuroblastoma tumorigenesis, although the exact mechanism is poorly defined. Treatment side-effects are extensive in treatment of children receiving conventional chemo-radiotherapy for neuroblastoma. Retinoids have a low side-effect profile and are used in children with neuroblastoma at the point of minimal residual disease. Retinoids can simultane

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Alkawafi, Isma A. "Role of mammalian target of rapamycin (mTOR) signalling in BeWo trophoblast differentiation and fusion." Thesis, University of Warwick, 2015. http://wrap.warwick.ac.uk/76206/.

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Foetal growth and development is closely related to the placental transport function, since any defect in this function is associated with pathological foetal growth. Trophoblast differentiation into a multinucleate syncytium is a key biological mechanism. Transcriptional regulation of fusogenic genes to promote fusion and capacity for placental hormonogenesis is achieved by a coordinated action of signals such as cAMP and MAPKs. The mammalian target of rapamycin (mTOR) acts as a placental growth signalling sensor, and this has been implicated in the pathophysiology of diseases such as intraut

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4

Tang, Chung Yiu Jonathan. "CIS-regulatory integration of intrinsic transcription factors with target-derived signals in neuronal differentiation." Thesis, University of British Columbia, 2009. http://hdl.handle.net/2429/24210.

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We now know that expression of the appropriate terminal differentiation gènes (TDG), such as neuropeptides, neurotransmitters, ion channels, etcetera, in maturing neurons is controlled by cell-specific combinations of transcription factors and by signals secreted from the neurons' target cells. However, it is unclear how thèse two regulatory inputs are integrated inside neurons. In Drosophila, target-derived Bone Morphogenetic Protein (BMP) signals and a well-characterized combinatorial code of transcription factors activate expression of the FMRFa gene in the Tv neurons. Here, I performed a c

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5

Eusebio, Anthony R. "Characterization of downstream target genes regulated by ABF-1 in different states of B cell development." Scholarly Commons, 2005. https://scholarlycommons.pacific.edu/uop_etds/618.

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The ABF-1 gene encodes for a protein that belongs to the basic helix-loop-helix family of transcription factors. ABF-1 mRNA molecules have been detected in the lymphoid tissues, which include the bone marrow, lymph nodes, and appendix, as well as transformed B cells lines infected with Epstein-Barr virus. This study investigates the role of ABF-1 in regulating downstream target genes in the human mature B cell line RAJI, as well as the plasma cell line, ARH-77. Quantitative real-time polymerase chain reaction and DNA microarray technology was used to investigate target genes that are subjected

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6

Berndt, Anthony Jason Erich. "Cis-regulatory integration of intrinsic and target-dependent regulators is required for terminal differentiation of Drosophila neurons." Thesis, University of British Columbia, 2015. http://hdl.handle.net/2429/55193.

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7

Yánez-Marcayata, Diana Carolina. "The role of Hedgehog signalling and its target genes in T helper differentiation and Th2 mediated disease." Thesis, University College London (University of London), 2018. http://discovery.ucl.ac.uk/10045576/.

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The process through which CD4 T-cells develop into Th1 and Th2 subsets has been the topic of intensive studies and many proteins are described to be involved. The Hedgehog (Hh) signalling pathway comprises a family of morphogens that are essential during mammalian organogenesis and in the development and homeostasis of T-cells. In addition, Hh signalling is involved in the differentiation of murine Th2 cells and contributes to the development of allergic airway disease. The family of Foxa2 transcription factors are Hedgehog target genes that have also been implicated in the regulation of the i

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8

Dingels, Nicole Katherine. "Oxidized soybean oil alters the expression of PPAR gamma and target genes in 3T3-L1 cells." Digital Archive @ GSU, 2012. http://digitalarchive.gsu.edu/nutrition_theses/40.

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Background: The typical western diet contains foods with modest amounts of lipid oxidation products. Previous work by us and others have demonstrated that mildly oxidized lipids promote a gain in fat mass while highly oxidized lipids decrease fat mass in rodents and triglyceride (TAG) accumulation in 3T3-L1 cells. Adipocyte differentiation is regulated by a key nuclear transcription factor known as PPARγ. Objective: To investigate if the alterations in triglyceride accumulation in 3T3-L1 cells pretreated with oxidized soy oil are due to 1) a change in PPARg DNA interactions 2) changes in the

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9

Hammon, Kathrin [Verfasser], and Wolfgang [Akademischer Betreuer] Herr. "IDH mutations as immune target and their effect on dendritic cell differentiation and metabolism / Kathrin Hammon ; Betreuer: Wolfgang Herr." Regensburg : Universitätsbibliothek Regensburg, 2019. http://d-nb.info/120188408X/34.

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10

Mändl, Julia [Verfasser], and Martin [Akademischer Betreuer] Müller. "The Growth Differentiation Factor 15 – a Novel Cellular Target Gene for Oncogenic Human Papillomaviruses / Julia Mändl ; Betreuer: Martin Müller." Heidelberg : Universitätsbibliothek Heidelberg, 2021. http://d-nb.info/1236812964/34.

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11

MARIANI, JESSICA. "Transcriptional regulation, target genes and functional roles of the SOX2 transcription factor in mouse neural stem cells maintenance and neuronal differentiation." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2009. http://hdl.handle.net/10281/8321.

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The aims of this PhD research were: to examine molecular mechanisms underlying the transcriptional regulation of the Sox2 gene during forebrain development; to examine the role of Sox2 for the proper neuronal differentiation of neural stem cells; and to examine the role of Sox2 in controlling the maintenance of neural stem cells (in vivo and in vitro). The aim of the first work (Chapter 1) was to investigate the transcription factors and the regulatory sequences that control transcription of the Sox2 gene in the developing brain and neural stem cells. Our laboratory previously identified Sox2

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12

Mekhail, Mina. "Injectable purine-based sponges to promote oligodendrocyte progenitor cells' attachment and differentiation: a potential therapy to target remyelination post-spinal cord injuries." Thesis, McGill University, 2014. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=123217.

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Demyelination is one of the adverse events that persist during both the acute and chronic stages of spinal cord injury (SCI). Intact axons that survive the initial trauma but lose their myelin undergo degeneration if myelin is not re-instated. Incomplete remyelination takes place by an endogenous population of progenitor cells called Oligodendrocyte Progenitor Cells (OPCs). The consensus in the literature is that abnormal myelin is a result of the inability of OPCs to undergo complete differentiation at the site of injury. Therefore, providing an environment conducive of OPC differentiation af

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13

Colombetti, Sara. "Dissecting the molecular mechanisms regulating proliferation, antigen responsiveness, and differentiation of CD4âº T lymphocytes : a central role for the mammalian target of Rapamycin (mTor)." Thesis, Open University, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.403837.

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14

Naillat, F. (Florence). "Roles of Wnt4/5a in germ cell differentiation and gonad development & ErbB4 in polarity of kidney epithelium." Doctoral thesis, Oulun yliopisto, 2011. http://urn.fi/urn:isbn:9789514295751.

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Abstract The embryonic urogenital system generates the metanephric kidneys, the gonads and the adrenal glands, and its development is based on sequential and reciprocal cell and tissue interactions. The mechanisms which regulate urogenital ontogeny are still poorly understood. In this thesis, the roles of Wnt-4 and ErbB4 functions in gonad and kidney development were analysed by using in vivo functional genomic technologies. Wnt-4 is crucial in female development since its absence leads to a partial female to male sex reversal. We found that Wnt-4 mediated the interactions between the somatic

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15

Ranjan, Ashish. "Targeted differentiation of ES cell into serotonergic neurons." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2015. http://dx.doi.org/10.18452/17258.

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Serotonin ist ein Neurotransmitter im zentralen Nervensystem (ZNS), die eine Vielzahl von Funktionen in der menschlichen Physiologie hat. Serotonergen Neuronen in der Raphe-Kerne des Gehirns Unser Ziel war die Leitung der Differenzierung von embryonalen Stammzellen (ES-Zellen) eingeengt und pluripotenten Stammzellen (iPS) Zellen in eine angereicherte Population von Serotonin-produzierenden Zellen, neuartige Gene, die wesentlich für die Entwicklung zu identifizieren und die Funktion des serotonergen Systems. Zu diesem Zweck haben wir differenzierten ES-Zellen in Serotonin-produzierenden Neuron

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16

McBride, Sarah. "ELUCIDATING BIOPHYSICAL CUES CONDUCIVE TO TARGETED MULTIPOTENT CELL DIFFERENTIATION." Case Western Reserve University School of Graduate Studies / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=case1196435881.

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17

Kydonaki, Maria. "Effects of HOXB4 downstream targets on the haemopoietic differentiation of pluripotent stem cells." Thesis, University of Edinburgh, 2016. http://hdl.handle.net/1842/22056.

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Attempts for the in vitro differentiation of reconstituting human HSCs from ESCs have been unsuccessful as key factors of HSC specification remain unclear. Enforced HOXB4 expression can enhance haemopoietic differentiation of mouse and human ESCs and generate reconstituting HSCs from mouse ESCs. We have previously shown that HOXB4 can enhance haemopoietic differentiation of mouse ESCs in a paracrine manner. Microarray analysis identified a number of secreted factors upregulated by HOXB4 potentially mediating this paracrine effect. The aim of this study was to assess whether these factors alone

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18

Yang, Ya-Ting. "Molecularly targeted therapy for ovarian cancer." Columbus, Ohio : Ohio State University, 2006. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1149015359.

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19

Spratt, Spencer. "A search for direct transcriptional targets of Hedgehog signalling involved in late neuronal cell differentiation." Thesis, University of Oxford, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.426095.

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20

Miller, Duncan. "Nodal signalling during targeted differentiation of human embryonic stem cells towards definitive endoderm." Thesis, University of Manchester, 2013. https://www.research.manchester.ac.uk/portal/en/theses/nodal-signalling-during-targeted-differentiation-of-human-embryonic-stem-cells-towards-definitive-endoderm(f468aa48-0830-42fe-98ee-1edff7ad1a5e).html.

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Targeted differentiation of human embryonic stem cells (hESCs) towards definitive endoderm (DE) is the first step in generating hepatic or pancreatic cell types with potential for clinical application. Characterisation and efficiency of DE differentiation is improving, however the specific effects of the different exogenous growth factors used, and the changing presence and activity of endogenous factors, are still not well understood. One such endogenous factor, the TGFβ ligand Nodal, is known to drive patterning and differentiation of the primitive streak and DE in the developing mouse embry

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Ignatz-Hoover, James J. "TLR8 and Nuclear GSK3ß are Novel Therapeutic Targets in AML." Case Western Reserve University School of Graduate Studies / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=case1480509044211523.

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22

Airey, Damien M. "Prompting beginning teachers to purposefully consider and implement differentiation: Connecting frameworks to targeted actions." Thesis, Griffith University, 2020. http://hdl.handle.net/10072/398437.

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Beginning teachers often experience a range of challenges in their early years of teaching. From the complexities associated with planning sizeable learning sequences to the micro-skills required for classroom management, many beginning teachers can feel overwhelmed and become disenchanted with the work they do. Managing learning activities and differentiating for the diverse needs of every student in the classroom is a significant source of anxiety for many beginning teachers. Differentiation is, within itself, a complicated and involved process concerned not only with knowing students, but a

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23

Hargreaves, Joyce. "Differentiating stalking : an interpersonal model of variation in the stalking process, as a function of prior stalker - target relationship." Thesis, University of Liverpool, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.419641.

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24

Ranjan, Ashish [Verfasser], Michael [Akademischer Betreuer] Bader, Udo [Akademischer Betreuer] Heinemann, and Heidrun [Akademischer Betreuer] Fink. "Targeted differentiation of ES cell into serotonergic neurons / Ashish Ranjan. Gutachter: Michael Bader ; Udo Heinemann ; Heidrun Fink." Berlin : Humboldt Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2015. http://d-nb.info/1074459393/34.

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25

Lau, Tze Chin. "In vitro and in vivo analyses of the impact of Mab21l2 and its targets on neural patterning and differentiation in vertebrates /." View abstract or full-text, 2010. http://library.ust.hk/cgi/db/thesis.pl?BIOL%202010%20LAU.

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26

Vert, Joshua Christopher. "Hypersaline Lake Environments Exhibit Reduced Microbial Dormancy." BYU ScholarsArchive, 2013. https://scholarsarchive.byu.edu/etd/4050.

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From acid seeps and deep-sea thermal vents to glacial ice and hypersaline lakes, extreme environments contain relatively simplified communities consisting of extremophiles that have evolved to survive and thrive under adverse abiotic conditions. In more neutral environments, microorganisms use dormancy as a common life history strategy to weather temporal fluctuations of resources or stresses until more 'optimal' conditions are present. It is unclear if dormancy is an essential survival mechanism for microorganisms in extreme environments; however, recent studies suggest that extreme environme

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Scherger, Anna Katharina [Verfasser], Ulrich [Akademischer Betreuer] Keller, Angelika [Gutachter] Schnieke, and Ulrich [Gutachter] Keller. "Activated gp130 signaling selectively targets B cell differentiation to drive malignant transformation / Anna Katharina Scherger ; Gutachter: Angelika Schnieke, Ulrich Keller ; Betreuer: Ulrich Keller." München : Universitätsbibliothek der TU München, 2020. http://d-nb.info/1220320978/34.

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Mohammed, Omar Jasim Mohammed. "Screening for potential embryotoxicity of phytochemicals and gestational diabetes mellitus using the chick cardiomyocyte micromass system and stem cell differentiation : prediction by molecular targets." Thesis, University of Nottingham, 2017. http://eprints.nottingham.ac.uk/47290/.

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Congenital heart defects are a leading cause of postnatal loss; they could genetically or environmentally induced. Herbal remedies are often used during the early stages of pregnancy, being considered ‘harmless’ and ‘natural'. To alleviate pregnancy-induced symptoms, women frequently use herbal medicines such as ginger to relieve nausea and vomiting - ‘morning sickness’, gingko biloba and ginseng as dietary supplements or tonics to boost body energy and blood circulation, particularly to the brain. Also, chamomile and holy basil are recommended to promote calmness and reduce stress, often rela

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Winkler, Sandra, Madlen Hempel, Sandra Brückner, Hans-Michael Tautenhahn, Roland Kaufmann, and Bruno Christ. "Identification of pathways in liver repair potentially targeted by secretory proteins from human mesenchymal stem cells." Universitätsbibliothek Leipzig, 2016. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-207430.

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Background: The beneficial impact of mesenchymal stem cells (MSC) on both acute and chronic liver diseases has been confirmed, although the molecular mechanisms behind it remain elusive. We aim to identify factors secreted by undifferentiated and hepatocytic differentiated MSC in vitro in order to delineate liver repair pathways potentially targeted by MSC. Methods: Secreted factors were determined by protein arrays and related pathways identified by biomathematical analyses. Results: MSC from adipose tissue and bone marrow expressed a similar pattern of surface markers. After hepatocytic diff

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Smith, Jordan L. "Reversing Cancer Cell Fate: Driving Therapeutic Differentiation of Hepatoblastoma to Functional Hepatocyte-Like Cells." eScholarship@UMMS, 2020. https://escholarship.umassmed.edu/gsbs_diss/1067.

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Background & Aims: Despite advances in surgical care and chemotherapeutic regimens, the five-year survival rate for Stage IV Hepatoblastoma (HB), the predominant pediatric liver tumor, remains at 27%. YAP1 and β-Catenin co-activation occurs in 80% of children’s HB; however, a lack of conditional genetic models precludes exploration of tumor maintenance and therapeutic targets. Thus, the clinical need for a targeted therapy remains unmet. Given the predominance of YAP1 and β-catenin activation in children’s tumors, I sought to evaluate YAP1 as a therapeutic target in HB. Approach & Results: Her

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Zhou, Qiong. "O comércio intra-sectorial na indústria agro-alimentar nos países BRIC." Master's thesis, Instituto Superior de Economia e Gestão, 2012. http://hdl.handle.net/10400.5/4973.

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Mestrado em Contabilidade, Fiscalidade e Finanças Empresariais<br>Esta dissertação analisa a evolução do comércio intra-sectorial total e por tipos (comércio intra-sectorial horizontal e vertical) na indústria agro-alimentar do Brasi, Rússia, Índia e China (os chamados BRIC). É feita, também, a caracterização dos quatro países em termos do seu peso nas exportações e importações de produtos agro-alimentares. A metodologia usada utiliza o índice de Comércio intra-sectoriasl de Grubel e Lloyd (1975) e o método de Abd-El-Rahaman (1971) e de Greenaway, Hine e Milner (1994) para separar o comércio i

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32

Richard, Geoffrey. "Étude du rôle des facteurs de transcription inducteurs d’EMT dans la mélanomagenèse." Thesis, Lyon 1, 2015. http://www.theses.fr/2015LYO10141/document.

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Les facteurs de transcription inducteurs de la transition épithélio-mésenchymateuse (EMT) sont fréquemment réactivés de manière aberrante dans de nombreux cancers. Dans les carcinomes, ils favorisent dans les étapes précoces le développement tumoral en inhibant les systèmes de sauvegarde tels que la sénescence ou l'apoptose et à terme dans les étapes finales, promeuvent la formation de métastases. Dans le cadre du mélanome nous avons mis en évidence des fonctions antagonistes de ces facteurs : il était connu que ZEB2 et SNAIL2 sont impliqués dans la délamination de la crête neurale et la déter

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Guidi, Mònica. "Micro RNA-Mediated regulation of the full-length and truncated isoforms of human neurotrophic tyrosine kinase receptor type 3 (NTRK 3)." Doctoral thesis, Universitat Pompeu Fabra, 2009. http://hdl.handle.net/10803/7114.

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Neurotrophins and their receptors are key molecules in the development of the<br/>nervous system. Neurotrophin-3 binds preferentially to its high-affinity receptor<br/>NTRK3, which exists in two major isoforms in humans, the full-length kinaseactive<br/>form (150 kDa) and a truncated non-catalytic form (50 kDa). The two<br/>variants show different 3'UTR regions, indicating that they might be differentially<br/>regulated at the post-transcriptional level. In this work we explore how<br/>microRNAs take part in the regulation of full-length and truncated NTRK3,<br/>demonstrating that the two isof

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Ben, Elhadj-Ben Brahim Nada. "contributions a l'économie de la publicité." Thesis, Aix-Marseille 2, 2011. http://www.theses.fr/2011AIX24009/document.

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Nous nous proposons, dans le cadre de cette thèse d'examiner des modèles économiques dans lesquels les firmes ont recours à différentes approches de publicité. Nous analysons les effets des investissements et des tarifs publicitaires sur les stratégies des annonceurs et des médias et nous étudions les différentes configurations de marché qui émergent à l'équilibre. Nous nous focalisons dans les Chapitres 2, 3 et 4 sur la publicité informative ciblée. Dans les chapitres suivants nous considérons que la publicité est persuasive et qu'elle peut créer des externalités aussi bien positives que néga

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Poiraudeau, Loïc. "Identification de nouvelles cibles thérapeutiques dans le cancer neuroendocrine de la prostate." Electronic Thesis or Diss., université Paris-Saclay, 2023. http://www.theses.fr/2023UPASL143.

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Le cancer de la prostate est le cancer le plus fréquent chez l'homme et il constitue la deuxième cause de mortalité par cancer chez l'homme dans les pays industrialisés. Le traitement systémique de ces cancers repose sur une déprivation androgénique par castration chirurgicale ou pharmacologique. Le cancer de la prostate métastatique résistant à la castration (mCRPC) est traité par des inhibiteurs de la voie des androgènes (ARPI). Cependant, environ un tiers des patients ne sont pas sensibles à ces médicaments et les autres, sensibles initialement, développent malheureusement une résistance se

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Mouilleau, Vincent. "Etude des mécanismes du développement de la moelle épinière humaine par la mise en place de modèles in vitro dérivés de cellules souches pluripotentes humaines." Thesis, Université Paris-Saclay (ComUE), 2019. http://www.theses.fr/2019SACLS407.

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La mise en place des circuits moteurs dépend, au cours du développement, de la spécification de plusieurs milliers de types de motoneurones (MNs) distincts générés à différentes positions le long de l’axe rostro-caudal (R-C) de la moelle épinière. En fonction de leur localisation, ces MNs acquièrent des propriétés particulières telles que la position des corps cellulaires ou encore la spécificité de leurs projections axonales vers leur muscles cible. La diversification des MNs est en correspondance avec différents segments de la moelle épinière : cervical, brachial, thoracique, lombaire et sac

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Barreau, Kristell. "Le peptide NFL-TBS, 40-63 dérivés des neurofilaments : Agents thérapeutique prometteur pour cibler et manipuler les cellules souches neurales et les cellules de glioblastomes Review of Clinical Trials Using Neural Stem Cells The Neurofilament‐Derived Peptide NFL‐TBS.40‐63 Targets Neural Stem Cells and Affects Their Properties The carbocyanine dye DiD labels in vitro and in vivo neural stem cells of the subventricular zone as well as myelinated structures following in vivo injection in the lateral ventricle." Thesis, Angers, 2017. http://www.theses.fr/2017ANGE0087.

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Les travaux menés au laboratoire ont mis en évidence des sites de liaison de la tubuline (TBS pour Tubulin Binding Site) sur les filaments intermédiaires, tels que les neurofilaments (NFs), qui sont spécifiquement exprimés par les neurones. Le peptide NFL-TBS.40-63 qui correspond à la séquence en acide aminés du TBS situé sur la sous unité légère des NFs, a montré des propriétés anti-glioblastomes in vitro et in vivo, sans effet sur les cellules saines environnantes (neurones et astrocytes). De plus, Il est aussi capable d’induire la différenciation et la maturation des précurseurs d’oligodend

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Lambert, Mélanie. "Etude de l’inhibition fonctionnelle du facteur de transcription HOXA9 par des ligands de l’ADN dans les Leucémies Aiguës Myéloïdes." Electronic Thesis or Diss., Université de Lille (2018-2021), 2018. http://www.theses.fr/2018LILUS060.

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Le traitement des leucémies aiguës myéloïdes (LAM) repose encore principalement sur la chimiothérapie conventionnelle alliant aracytine (AraC) et dérivé d'anthracycline conduisant à environ 30% de guérison chez les patients de 65 ans et plus. Ce mauvais pronostic est essentiellement lié aux fréquentes rechutes, souvent chimiorésistantes, et au peu de thérapies ciblées en clinique. Seuls certains sous-types de LAM bénéficient de nouveaux traitements ciblés (Midostaurin, Mylotarg, Enasidenib). HOXA9 est un facteur de transcription surexprimé dans environ 70% des LAM de différents sous-types molé

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Tyler, William Andrew. "Activation of the mammalian target of rapamycin (mTOR) is essential for oligodendrocyte differentiation." 2007. http://etda.libraries.psu.edu/theses/approved/WorldWideIndex/ETD-2177/index.html.

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40

Kung, Fang-Yi, and 龔芳儀. "The Market Differentiation and Target Market Selection of Credit Card Customer- A Quantile Regression Analysis." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/ag7v3x.

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碩士<br>中原大學<br>企業管理研究所<br>102<br>Since 1980s, credit card is a critical banking business in Taiwan. According to the information of a famous domestic bank, the number of issued Costco Co-Branded Card is one of the most popular credit cards. In other words, the accompanied profit is considerable. Different from other wholesale warehouses, Costco is the unique membership-only whole sale club in Taiwan. Customers to purchase goods from Costco should pay membership fee first. The customer attributes of Costco Co-Branded Card holders, who like to own the membership of Costco, can be an valuable busi

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Pun, Pou-Chu. "CD24 is a Potential Therapeutic Target of Hepatocellular Carcinoma: Role in cell proliferation, differentiation and invasion." 2006. http://www.cetd.com.tw/ec/thesisdetail.aspx?etdun=U0001-2707200611525400.

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Pun, Pou-Chu, and 潘寶珠. "CD24 is a Potential Therapeutic Target of Hepatocellular Carcinoma: Role in cell proliferation, differentiation and invasion." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/35953887523946198007.

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碩士<br>國立臺灣大學<br>病理學研究所<br>94<br>CD24 is a surface protein consisting of a short, heavily-glycosylated protein core linked to plasma membrane by a glycosylphosphatidylinositol (GPI) anchor. CD24 is a cluster of differentiation (CD) marker of hematopoietic lineages and plays a role in B-cell development and neurogenesis. CD24 functions as an adhesion molecule and interacts with P-selectin and L1. Cumulative evidence has demonstrated CD24 expression in many common malignancies and association with metastasis. Despite the multitude of human tissue studies correlating CD24 expression with tumorigen

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Jalal, Ahmed Heba M. "A PHOSPHOPROTEOMICS STUDY REVEALS PAK2 AS A THERAPEUTIC TARGET DURING CD44-INDUCED DIFFERENTIATION OF AML CELLS." Diss., 2019. http://hdl.handle.net/10754/660351.

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Acute myeloid leukemia (AML) is a clonal malignant disease characterized by a blockage in the differentiation of myeloid cells resulting in the accumulation of highly proliferating immature blast cells. With the success of All Trans Retinoic acid (ATRA) in acute promyelocytic leukemia (AML3), differentiation therapy has become a very attractive treatment option. Ligation of CD44 (a cell surface antigen) with anti-CD44 monoclonal antibodies (mAbs) is reported to reverse the blockage of differentiation and suppress the proliferation of blasts derived from most AML subtypes. However, the molecula

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Hsiao, Yi-Wen, and 蕭亦文. "The Differentiation of Domapinergic Neurons from Bone Marrow-Derived Mesenchymal Stem Cells Modified by DNA Target Methylation." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/14653416337431288105.

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碩士<br>國立中正大學<br>化學工程研究所<br>101<br>Stem cell replacement therapy has been thought to be an alternative treatment for Parkinson’s disease. Mesenchymal stem cells can be gained from many tissues and transplanted to human body with less transplant rejection. So, they have been studied widely for differentiation to many kinds of functional cell under appropriate media. In this study, we used the cell line - me_SWH-treated MSCs cells which were resulted from in vitro DNA target methylation of intact MSC cells as our research model. The main advantage of this cell line is that it has a rapid prolifer

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Brites, Raquel De Machado Neto e. Santos. "Consulting project with the topic: “Ageas consulting field lab on a cyber risk value proposition –points of parity and points of differentiation in a beyond insurance offer”." Master's thesis, 2021. http://hdl.handle.net/10362/124204.

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The project focuses on the strategic assessment of the potential value for insurer sincy berrisk and the development of a comprehensive and successful value proposition for Ageas in this market. To fulfil these objectives, external and internal analyses were conducted, to identify opportunities and threats of the cyber insurance market and Ageas’ strengths and challenges to enter in it. After wards, profitability indicators (market size and claims ratio) were measured to understand the potential for Ageas in this market. The team proceeded by formulating hypotheses and testing them through ind

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(9133214), Jacob Louis Owens. "Protein arginine methyltransferase 5 (PRMT5) is an essential regulator of the cellular response to ionizing radiation and a therapeutic target to enhance radiation therapy for prostate cancer treatment." Thesis, 2020.

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Prostate cancer is one of the most frequently diagnosed cancers and failure to manage localized disease contributes to the majority of deaths. Radiation therapy (RT) is a common treatment for localized prostate cancer and uses ionizing radiation (IR) to damage DNA. Although RT is potentially curative, tumors often recur and progress to terminal disease. The cellular response to RT is multidimensional. For example, cells respond to a single dose of IR by activating the DNA damage response (DDR) to repair the DNA. Targeting proteins involved in the DDR is an effective clinical strategy to sensit

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Valente, Sara Cristiana Alves. "Mitochondrial performance during osteoblast differentiation: searching new targets to counteract osteoporosis." Master's thesis, 2019. http://hdl.handle.net/10316/87922.

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Dissertação de Mestrado em Bioquímica apresentada à Faculdade de Ciências e Tecnologia<br>A osteoporose é uma doença crónica e assintomática caracterizada pela perda de densidade óssea e pela deterioração estrutural do osso. Isto leva à diminuição da resistência óssea e aumento do risco de fraturas, suscetível de gerar incapacidade física e dependência de terceiros. O decréscimo dos níveis de estrogénios que ocorre nas mulheres após a menopausa aumenta a fragilidade óssea. A osteoporose é, portanto, uma grande preocupação para as mulheres em processo de envelhecimento após a menopausa. O aumen

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Lu, Mu-Jie, and 盧慕潔. "Investigation of EKLF-targeted genes during erythroid terminal differentiation." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/10588016616471231449.

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碩士<br>國立陽明大學<br>生命科學系暨基因體科學研究所<br>102<br>Erythropoiesis is a multi-step process for production of red blood cells from pluripotent hematopoietic stem cells (HSCs). Erythroid Krüppel-like Factor (EKLF) is a critical transcription factor that functions in erythropoiesis, in particular, the erythroid terminal differentiation. It has been demonstrated that EKLF is required for the activation of adult β globin gene in mouse and human. The transactivation model shows that it participates in the remodeling of the chromatin through interactions with CBP/p300 and the SWI/SNF complex at the β globin gen

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Lee, Yun-Jia, and 李云嘉. "The Targets and Functions of E3 Ubiquitin ligase RNF149 in Gonocyte Differentiation." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/8fw8x3.

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碩士<br>國立臺灣海洋大學<br>食品科學系<br>102<br>The ubiquitin proteasome system (UPS) consists of a cascade of enzymatic reactions leading to the ubiquitination of proteins with consequent degradation or altered functions of the proteins. Alterations in UPS genes have been associated with male infertility suggesting the role of UPS in spermatogenesis. The protein is a RING domain-containing E3 ubiquitin ligase involving control of gene transcription, translation, cytoskeletal organization, cell adhesion, and epithelial development. Spermatogenesis relies on the existence of a pool of germline stem cells, th

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"Targeted differentiation of embryonic stem cells towards the neural fate." Thesis, 2009. http://library.cuhk.edu.hk/record=b6074764.

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Embryonic stem (ES) cells, which possess proliferating and differentiating abilities, are a potential source of cells for regenerative medicine. Nowadays, the challenge in using ES cells for developmental biology and regenerative medicine has been to direct the wide differentiation potential towards the derivation of a specific cell fate. This study is aimed to establish a simple and efficient method to derive ES cells into neural lineage cells and examine the safety and efficacy of derived cells in a mouse ischemic stroke model. To explore the underlying mechanisms responsible for lineage com

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