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Journal articles on the topic 'Target Fascination'

Author: Grafiati

Published: 4 June 2021

Last updated: 12 February 2022

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1

Larson, K. Maya. "Nabokov's ‘Diabolical Task’: Translation as Capture and Becoming-Butterfly." Deleuze and Guattari Studies 14, no. 4 (2020): 585–603. http://dx.doi.org/10.3366/dlgs.2020.0419.

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The lepidopteral imaginary that animates Nabokov's relationship to translation can be understood in light of Deleuze and Guattari's notions of ‘apparatus of capture’ and ‘rhizomatic becomings’. On the one hand, Nabokov's scientific fascination with butterflies frames his radically literal approach to translation. The scientific dissection of texts and butterflies ‘captures’ an original and singular content as it flutters, reducing it to the homogenised content of a target source. On the other hand, in Speak, Memory's engagement with ‘multiple metamorphoses, familiar to butterflies’, Nabokov as

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Naghmeh-Abbaspour, Bita, Tengku Sepora Tengku Mahadi, and Marlina Jamal. "THE IMPACT OF DOMINANT IDEOLOGY OF TARGET SOCIETY ON LEXICAL CHOICES OF TRANSLATION: THE CASE STUDY OF THE ESSENTIAL RUMI." Humanities & Social Sciences Reviews 7, no. 6 (2020): 1162–71. http://dx.doi.org/10.18510/hssr.2019.76166.

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Purpose: The current research investigates the translator’s lexical choices in terms of ideological concepts of The Essential Rumi. Moreover, by providing an overview of the social context of the target society, the study supports the logic behind the lexical choices. Methodology: Based on the association of ideology and critical discourse analysis as well as considering manipulation as one of the central concepts of it, the study employs CDA as its theoretical and analytical framework. Main Findings: The finding reveals that the Islamic ideology of Rumi’s poetry is extremely manip

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Diala, Isidore. "Nigeria and the Poetry of Travails: The Niger Delta in the Poetry of Uche Umez." Matatu 33, no. 1 (2006): 317–25. http://dx.doi.org/10.1163/18757421-033001036.

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Especially since the execution of the writer and Ogoni activist, Ken Saro–Wiwa, international attention has been drawn to the plight of the Niger Delta. Oil-rich but cynically plundered and exploited, the Niger Delta has become symbolic of the Nigerian nation itself, fabulously endowed yet, paradoxically, virtually a beggar nation. This accounts in part for the increasing fascination of a growing number of Nigerian poets, Deltans and non-Deltans alike, with the representative plight of the Niger Delta. In , the first published volume of the emergent Nigerian writer Uche Peter Umez, Nigeria's c

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Plichta, Piotr. "Przekład elementów awangardowych w polskich i rosyjskich tłumaczeniach wierszy Charlesa Bukowskiego." Między Oryginałem a Przekładem 26, no. 49 (2020): 49–64. http://dx.doi.org/10.12797/moap.26.2020.49.03.

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Elements of Avant-garde Poetics and Aesthetics in the Polish and Russian Translations of Charles Bukowski’s Poems The poetics of Charles Bukowski’s lyrical verse can be considered avantgarde not only because of their scandalous and often scatological content. It also stems from the author’s philosophical fascination with the disintegration and ruthlessness of time, as well as the situation of the monadic isolation of the individual from the beings external to him. This, in turn, makes Bukowski a peripheral and separate phenomenon even within the polysystem of American culture: the transl

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Brown, Alan S. "Chunky, Spunky, and Cheap." Mechanical Engineering 121, no. 09 (1999): 50–54. http://dx.doi.org/10.1115/1.1999-sep-1.

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Most companies are applying innovative engineering ways and making unusual compromises to meet their target. One company, for example, plans to power its cars with remanufactured Volkswagen engines. Another wants to build a taxi with only two doors. The two-door Buddy taxi is meant to handle highways, dirt roads, and no road at all. Mud on the tires is part of the advertising pitch. Designers and engineers developing world cars have rarely worked for Detroit's Big Three. Many of them trace their fascination with cars back to the days when they built hot rods in their garages. Automotive Design

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Micek, Agnieszka, and Barbara Kmiecik-Niedziela. "The method of sensory integration in the therapy of children with autism." Health Promotion & Physical Activity 14, no. 1 (2021): 47–49. http://dx.doi.org/10.5604/01.3001.0014.7870.

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Children with autism often have difficulties with registering and interpreting information received from senses. Inadequate response to signals coming from senses, commonly encountered among them, may be associated with restricted stereotyped behaviours and social deficits, affecting their relationships, education and daily life activities. Children with autism may have impaired sensory perception, show hypersensitivity to environmental stimuli manifested by fascination or anxiety, e.g. they may feel distress due to constant quiet noise. Researchers have been studying the impact of sensory pro

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7

Clark, Caryl. "Haydn’s Judaizing of the apothecary." Studia Musicologica 51, no. 1-2 (2010): 41–60. http://dx.doi.org/10.1556/smus.51.2010.1-2.4.

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As the first Italian opera to grace the stage of the new opera house at Eszterháza, Lo speziale (1768) afforded Kapellmeister Haydn, and the singers and orchestral musicians under his direction, the opportunity to revel in comedic performance. The revised libretto translated well to the rural court of Prince Nicolaus, whose tastes and cultural patronage extended to opera buffa. As Matthew Head has argued ( Cambridge Companion , 2005), Sempronio, the apothecary of the title whose fascination with the exotic makes him an easy target for duping, is also a harbinger of difference. And this “differ

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Macnab, A. J., and R. Mukisa. "Celebrity endorsed music videos: innovation to foster youth health promotion." Health Promotion International 34, no. 4 (2018): 716–25. http://dx.doi.org/10.1093/heapro/day042.

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Abstract There are calls for innovation in health promotion and for current issues to be presented in new and exciting ways; in addition to creating engaging messages, novel ways to deliver health messaging are needed, especially where youth are the key target audience. When pupils in WHO Health Promoting Schools were asked what health messages would resonate with them, they also identified celebrities as the ‘messengers’ they would be particularly likely to listen to. Expanding on these discussions, the pupils quoted celebrity-recorded music videos containing health and lifestyle messaging as

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9

Putu Agung, Anak Agung, Made Tamba, and Ida Bagus Brata. "Building Adat Village-Based Tourism Destination Government System (Case of Pandawa Beach Tourism Destination, Kutuh Village, Kuta Selatan Sub-District)." International Journal of Contemporary Research and Review 9, no. 10 (2018): 20220–35. http://dx.doi.org/10.15520/ijcrr/2018/9/10/616.

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The development of Tourist Destination is newly become the alternative which is important progressively and insit on to the new atmosphere and warm image and also avoid impression monotonous. To realize the mentioned, hence the research of the system of management of tourist destinations is very urgently done by owning special target of research, that is: (1) System of analysis of environmental utility facility of Coastal Tourist Destination Pandawa Beach, (2) System analysis and pranata of management of Coastal tourist Destination management of Pandawa Beach, (3) analyzing storey at Pandawa B

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10

Hamilton, Susan E., and David R. Corey. "Telomerase: anti-cancer target or just a fascinating enzyme?" Chemistry & Biology 3, no. 11 (1996): 863–67. http://dx.doi.org/10.1016/s1074-5521(96)90173-8.

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11

Noronha, Silvana Aparecida Alves Corrêa de, Linda Bernardes, Samuel Marcos Ribeiro de Noronha, Fernanda Amorim de Morais Nascimento, and Lydia Masako Ferreira. "SOCIAL INCLUSION AND SOLIDARITY IN STRICT POST-GRADUATION: EXPERIENCING THE LABORATORY "SCIENTIFIC WAKE FOR THE FUTURE" (PRIMARY AND SECONDARY EDUCATION)." Revista do Colégio Brasileiro de Cirurgiões 42, suppl 1 (2015): 44–47. http://dx.doi.org/10.1590/0100-69912015s01016.

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Objective: To stimulate and awakening the interest of students of high school or elementary public schools in research and science through scientific initiation stages in the Postgraduate Program in Translational Surgery. To stimulate and awakening the interest of students of high school or elementary public schools in research and science through scientific initiation stages in the Postgraduate Program in Translational Surgery. Method: The target audience for the development of scientific activities were students enrolled in mid-level course (second year initially) and have approval of their

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Holst, Søren, Dorte Lystrup, and John L. Taylor. "Firesetters with intellectual disabilities in Denmark." Journal of Intellectual Disabilities and Offending Behaviour 10, no. 4 (2019): 72–81. http://dx.doi.org/10.1108/jidob-10-2019-0021.

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Purpose The purpose of this paper is to gather epidemiologicalinformation concerning firesetters with intellectual disabilities (ID) in Denmark to identify the assessment and treatment needs of this population and inform further research in this area. Design/methodology/approach The records held by the Danish Ministry of Justice concerning all firesetters with ID convicted of deliberate firesetting were reviewed for the period January 2001 to December 2010 inclusive. File information was extracted for 83 offenders concerning: demographic and personal characteristics; mental health characterist

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Varfolomeev, Eugene, and Domagoj Vucic. "Inhibitor of apoptosis proteins: fascinating biology leads to attractive tumor therapeutic targets." Future Oncology 7, no. 5 (2011): 633–48. http://dx.doi.org/10.2217/fon.11.40.

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Kelgiorgi, Dionysia, and Christos Dervenis. "Pancreatic neuroendocrine tumors: the basics, the gray zone, and the target." F1000Research 6 (May 10, 2017): 663. http://dx.doi.org/10.12688/f1000research.10188.1.

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Pancreatic neuroendocrine tumors (PanNETs) manifest with a range of symptoms and pose a therapeutic challenge. A team approach, in which many specialists come together, is necessary in the quest for the best patient-tailored treatment. Disciplines such as oncology, surgery, basic science, endocrinology, radiology, and nuclear medicine need to work side by side, equally contributing to patient care and to advancing our better understanding of this fascinating disease.

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Hughes, Scott J., and Alessio Ciulli. "Molecular recognition of ternary complexes: a new dimension in the structure-guided design of chemical degraders." Essays in Biochemistry 61, no. 5 (2017): 505–16. http://dx.doi.org/10.1042/ebc20170041.

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Molecular glues and bivalent inducers of protein degradation (also known as PROTACs) represent a fascinating new modality in pharmacotherapeutics: the potential to knockdown previously thought ‘undruggable’ targets at sub-stoichiometric concentrations in ways not possible using conventional inhibitors. Mounting evidence suggests these chemical agents, in concert with their target proteins, can be modelled as three-body binding equilibria that can exhibit significant cooperativity as a result of specific ligand-induced molecular recognition. Despite this, many existing drug design and optimizat

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Trivedi, Darshan V., Suman Nag, Annamma Spudich, Kathleen M. Ruppel, and James A. Spudich. "The Myosin Family of Mechanoenzymes: From Mechanisms to Therapeutic Approaches." Annual Review of Biochemistry 89, no. 1 (2020): 667–93. http://dx.doi.org/10.1146/annurev-biochem-011520-105234.

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Myosins are among the most fascinating enzymes in biology. As extremely allosteric chemomechanical molecular machines, myosins are involved in myriad pivotal cellular functions and are frequently sites of mutations leading to disease phenotypes. Human β-cardiac myosin has proved to be an excellent target for small-molecule therapeutics for heart muscle diseases, and, as we describe here, other myosin family members are likely to be potentially unique targets for treating other diseases as well. The first part of this review focuses on how myosins convert the chemical energy of ATP hydrolysis i

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Liu, Xianchen, Fuchao Yang, Jie Guo, Jing Fu, and Zhiguang Guo. "New insights into unusual droplets: from mediating the wettability to manipulating the locomotion modes." Chemical Communications 56, no. 94 (2020): 14757–88. http://dx.doi.org/10.1039/d0cc05801g.

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The ability to manipulate droplets can be utilized to develop various smart sensors or actuators, endowing them with fascinating applications for drug delivery, detection of target analytes, environmental monitoring, intelligent control, and so on.

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18

Fenda, Intan Yulia Febbyu, and Handriyotopo Handriyotopo. "METAPHOR IN THE FILM SETAN JAWA." Capture : Jurnal Seni Media Rekam 12, no. 2 (2021): 189–95. http://dx.doi.org/10.33153/capture.v12i2.3441.

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The Setan Jawa film depicts the two main characters' fascinating and expressive body language and motions (Setio and Asih). Accordingly, we formulate the research problem of the Setan Jawa film’s metaphor values. This study uses the metaphorical approach to search for the meanings of the film by analyzing the source and target domains. Our findings indicate that Setan Jawa encompasses both the romance source domain and the tragedy target domain. In sum, Setan Jawa is a film about perseverance, courage, intention, self-sacrifice, and ambition.

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19

Chaves, Sílvia, Luca Piemontese, Asha Hiremathad, and M. Amélia Santos. "Hydroxypyridinone Derivatives: A Fascinating Class of Chelators with Therapeutic Applications - An Update." Current Medicinal Chemistry 25, no. 1 (2018): 97–112. http://dx.doi.org/10.2174/0929867324666170330092304.

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Hydroxypyridinones (HPs) are a family of N-heterocyclic metal chelators, which have been an attractive target in the development of a variety of new pharmaceutical drugs, due to their high metal chelating efficacy/specificity and easy derivatization to tune the desired biological properties. In fact, along the last decades, hydroxypyridinone derivatives, but mostly 3-hydroxy-4-pyridinone (3,4-HP), have been intensively used in drug design, following either a multitarget approach, in which one chelating unity is extrafunctionalized (hybridized) to enable the interaction with other important spe

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20

Kawaler, Steven D. "Asteroseismology in Action: Pulsating Hot White Dwarfs." Symposium - International Astronomical Union 185 (1998): 261–68. http://dx.doi.org/10.1017/s0074180900238746.

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The development of helioseismology as a forefront area of solar and stellar astronomy has been fascinating to watch. Helioseismology takes full advantage of the benefits of lots of photons and a spatially resolved target. These allow measurement of tiny amplitude photospheric velocity and flux variations, and the precise identification of the oscillation modes corresponding to each observed frequency.

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21

Gelfer, Marylou Pausewang. "Voice Treatment for the Male-to-Female Transgendered Client." American Journal of Speech-Language Pathology 8, no. 3 (1999): 201–8. http://dx.doi.org/10.1044/1058-0360.0803.201.

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Male-to-female transsexuals are sometimes a part of a speech-language pathologist’s voice caseload. This article is intended to provide information and a suggested treatment approach to speech-language pathologists who work with this small but fascinating population. Aspects of the transition process, interviewing strategies, selection of a target frequency, and suggested treatment techniques are presented.

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22

Leask, Andrew. "Conjunction junction, what’s the function? CCN proteins as targets in fibrosis and cancers." American Journal of Physiology-Cell Physiology 318, no. 6 (2020): C1046—C1054. http://dx.doi.org/10.1152/ajpcell.00028.2020.

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Cellular communication network (CCN) proteins are matricellular proteins that coordinate signaling among extracellular matrix, secreted proteins, and cell surface receptors. Their specific in vivo function is context-dependent, but they play profound roles in pathological conditions, such as fibrosis and cancers. Anti-CCN therapies are in clinical consideration. Only recently, however, has the function of these complex molecules begun to emerge. This review summarizes and interprets our current knowledge regarding these fascinating molecules and provides experimental evidence for their utility

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Samuels, Richard. "The spatial reorientation data do not support the thesis that language is the medium of cross-modular thought." Behavioral and Brain Sciences 25, no. 6 (2002): 697–98. http://dx.doi.org/10.1017/s0140525x02470124.

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A central claim of the target article is that language is the medium of domain-general, cross-modular thought; and according to Carruthers, the main, direct evidence for this thesis comes from a series of fascinating studies on spatial reorientation. I argue that the these studies, in fact, provide us with no reason whatsoever to accept this cognitive conception of language.

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steels, luc, and tony belpaeme. "the semiotic dynamics of colour." Behavioral and Brain Sciences 28, no. 4 (2005): 515–24. http://dx.doi.org/10.1017/s0140525x05510082.

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the interesting and deep commentaries on our target article reflect the continued high interest in the problem of colour categorisation and naming. clearly, colour remains for many cognitive science related disciplines a fascinating microworld in which some of the most fundamental issues for cognition and culture can be studied. although our target article took the stance of practically oriented engineers who are trying to find the best solution for orchestrating the self-organisation of communication systems in artificial agents, most commentators focus on the implications for cognitive scien

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Sholihin, H. Hayat. "SINTESIS 7-FORMILINDOL SEBAGAI BAHAN DASAR PEMBENTUK KATALIS EPOKSIDASI BARU (SYNTHESIS OF 7-FORMYLINDOLE AS PRECURSOR OF NEW EPOXIDATION CATALYSTS)." Jurnal Pengajaran Matematika dan Ilmu Pengetahuan Alam 2, no. 1 (2015): 78. http://dx.doi.org/10.18269/jpmipa.v2i1.396.

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Manganese (III) salen complexes have been reported as epoxidation catalysts. It is caused a major breakthrough in the enantioselective epoxidation of alkenes into epoxide compounds. This catalyst was synthesized from salicylaldehyde derivatives. Based on the structure, salicylaldehyde is an isosteric nature of 7-folmylindole, consequently opened the door to an array of fascinating and versatile ligand systems, and offer tremendous scope for molecular designe, because of the greatly enhanced capacity for substitution of indoles compared with phenols. Initial target of the project to synthesize

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Matrone, Carmela, Federica Petrillo, Rosarita Nasso, and Gabriella Ferretti. "Fyn Tyrosine Kinase as Harmonizing Factor in Neuronal Functions and Dysfunctions." International Journal of Molecular Sciences 21, no. 12 (2020): 4444. http://dx.doi.org/10.3390/ijms21124444.

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Fyn is a non-receptor or cytoplasmatic tyrosine kinase (TK) belonging to the Src family kinases (SFKs) involved in multiple transduction pathways in the central nervous system (CNS) including synaptic transmission, myelination, axon guidance, and oligodendrocyte formation. Almost one hundred years after the original description of Fyn, this protein continues to attract extreme interest because of its multiplicity of actions in the molecular signaling pathways underlying neurodevelopmental as well as neuropathologic events. This review highlights and summarizes the most relevant recent findings

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Shvets, Alexey, Maria Kochugaeva, and Anatoly Kolomeisky. "Mechanisms of Protein Search for Targets on DNA: Theoretical Insights." Molecules 23, no. 9 (2018): 2106. http://dx.doi.org/10.3390/molecules23092106.

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Protein-DNA interactions are critical for the successful functioning of all natural systems. The key role in these interactions is played by processes of protein search for specific sites on DNA. Although it has been studied for many years, only recently microscopic aspects of these processes became more clear. In this work, we present a review on current theoretical understanding of the molecular mechanisms of the protein target search. A comprehensive discrete-state stochastic method to explain the dynamics of the protein search phenomena is introduced and explained. Our theoretical approach

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Ciulli, Alessio. "Targeted Protein Degradation with Small Molecules: How PROTACs Work." Proceedings 22, no. 1 (2019): 115. http://dx.doi.org/10.3390/proceedings2019022115.

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Bivalent degrader molecules (also termed PROTACs) target proteins for degradation through recruitment to E3 ligases. PROTACs are a revolutionary new modality class with therapeutic potential. Formation of a ternary complex between the degrader, the ligase, and the target leads to tagging by ubiquitination and proteasomal degradation of the target protein. In 2015, we disclosed MZ1, a potent degrader made of a ligand we had previously discovered for the E3 ligase von Hippel–Lindau (VHL), and a pan-selective ligand for the BET proteins Brd2, Brd3, and Brd4. We made the unexpected but fascinating

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Zhou, Liu, Teng Leng Ooi, and Zijiang J. He. "Intrinsic spatial knowledge about terrestrial ecology favors the tall for judging distance." Science Advances 2, no. 8 (2016): e1501070. http://dx.doi.org/10.1126/sciadv.1501070.

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Our sense of vision reliably directs and guides our everyday actions, such as reaching and walking. This ability is especially fascinating because the optical images of natural scenes that project into our eyes are insufficient to adequately form a perceptual space. It has been proposed that the brain makes up for this inadequacy by using its intrinsic spatial knowledge. However, it is unclear what constitutes intrinsic spatial knowledge and how it is acquired. We investigated this question and showed evidence of an ecological basis, which uses the statistical spatial relationship between the

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Saylan, Yeşeren, and Adil Denizli. "Advances in Molecularly Imprinted Systems: Materials, Characterization Methods and Analytical Applications." Current Analytical Chemistry 16, no. 3 (2020): 196–207. http://dx.doi.org/10.2174/1573411015666181214155042.

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Introduction: A molecular imprinting is one of the fascinating modification methods that employ molecules as targets to create geometric cavities for recognition of targets in the polymeric matrix. This method provides a broad versatility to imprint target molecules with different size, three-dimensional structure and physicochemical features. In contrast to the complex and timeconsuming laboratory surface modification procedures, this method offers a rapid, sensitive, inexpensive, easy-to-use, and selective approach for the diagnosis, screening and monitoring disorders. Owing to their unique

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Hapsari, Gatari Dwi. "INDONESIA IN TOBACCO CONTROL EFFORTS TO ACHIEVE SUSTAINABLE DEVELOPMENT GOALS TARGET 3.A." Sociae Polites 20, no. 1 (2019): 58–80. http://dx.doi.org/10.33541/sp.v20i1.1470.

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This paper entitled Indonesia’s effort in Tobacco Control to achieve 3.a targets of Sustainable Development Goals in 2017-2019, which is strengthen implementation of FCTC in all countries, as appropriate. This study is a fascinating case to research due to the growing prevalence of child smokers in Indonesia every year. The damage caused by this problem is multi-dimensional, which includes damage to the economy, economy, and social, even threatening the narration of the Indonesia Golden Era of 2045. This study supported by a sustainable development concept, non-military threat concepts, also p

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Yang, Ching-Hsu, Tzu-Heng Wu, Chia-Chen Chang, et al. "Biosensing Amplification by Hybridization Chain Reaction on Phase-Sensitive Surface Plasmon Resonance." Biosensors 11, no. 3 (2021): 75. http://dx.doi.org/10.3390/bios11030075.

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Surface Plasmon Resonance (SPR) is widely used in biological and chemical sensing with fascinating properties. However, the application of SPR to detect trace targets is hampered by non-specific binding and poor signal. A variety of approaches for amplification have been explored to overcome this deficiency including DNA aptamers as versatile target detection tools. Hybridization chain reaction (HCR) is a high-efficiency enzyme-free DNA amplification method operated at room temperature, in which two stable species of DNA hairpins coexist in solution until the introduction of the initiator stra

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Figueira, Flávio, José A. S. Cavaleiro, and João P. C. Tomé. "Silica nanoparticles functionalized with porphyrins and analogs for biomedical studies." Journal of Porphyrins and Phthalocyanines 15, no. 07n08 (2011): 517–33. http://dx.doi.org/10.1142/s1088424611003653.

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This review focus on the preparation of silica nanoparticles functionalized with porphyrins and related compounds. It is aimed to highlight their features as photosensitizers in the area of photodynamic therapy. In this field, photosensitizers have been covalently and non-covalently linked to silica nanoparticles, in order to study their photophysical and biological properties. Another fascinating scenario for photosensitizer-silica nanoparticles hybrids involves the possibility of including metal cores for conditioning the uptake in the target cells, allowing most of the times the combination

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Loewith, Robbie. "A brief history of TOR." Biochemical Society Transactions 39, no. 2 (2011): 437–42. http://dx.doi.org/10.1042/bst0390437.

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The TOR (target of rapamycin) serine/threonine kinases are fascinating in that they influence many different aspects of eukaryote physiology including processes often dysregulated in disease. Beginning with the initial characterization of rapamycin as an antifungal agent, studies with yeast have contributed greatly to our understanding of the molecular pathways in which TORs operate. Recently, building on advances in quantitative MS, the rapamycin-dependent phosphoproteome in the budding yeast Saccharomyces cerevisiae was elucidated. These studies emphasize the central importance of TOR and hi

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Kurniawan, Yudhi Dwi, and A'liyatur Rosyidah. "Strategies for the synthesis of brevipolides." Beilstein Journal of Organic Chemistry 17 (September 14, 2021): 2399–416. http://dx.doi.org/10.3762/bjoc.17.157.

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In recent years fifteen 5,6-dihydro-α-pyrone derivatives, bearing either a distinctive cyclopropane or furan ring and named brevipolides A–O (1–15), have been isolated from the invasive plant Hyptis brevipes Poit. Their fascinating structural features, and the potent biological activities, including cytotoxicity against an array of human cancer cell lines and inhibition of the chemokine receptor CCR5, make them attractive synthetic targets. This review article highlights the recent synthetic methodologies and briefly summarizes their biological activities.

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TIMMERMANN, ACHIM. "The Microarchitectural Stage-Management of Baptism from Lateran IV to the Counter-Reformation." Journal of Ecclesiastical History 71, no. 3 (2020): 527–61. http://dx.doi.org/10.1017/s0022046920000056.

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Although not liturgically mandated, the ostentatious microarchitectural font cover became one of the most significant ecclesiastical furnishings of the later Middle Ages. In fact, as a church fixture it survived well into the seventeenth century, not only in Catholic but also in Protestant regions, even though its eye-catching forms represented an obvious target for radical reformers and iconoclasts. Despite their enduring presence and their obvious importance to the communities that erected them, font covers remain little researched and understood. Revolving around a discussion of their inten

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Rahman, Maryam, Gregory J. A. Murad, Frank Bova, William A. Friedman, and J. Mocco. "Stereotactic radiosurgery and the linear accelerator: accelerating electrons in neurosurgery." Neurosurgical Focus 27, no. 3 (2009): E13. http://dx.doi.org/10.3171/2009.7.focus09116.

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The search for efficacious, minimally invasive neurosurgical treatment has led to the development of the operating microscope, endovascular treatment, and endoscopic surgery. One of the most minimally invasive and exciting discoveries is the use of targeted, high-dose radiation for neurosurgical disorders. Radiosurgery is truly minimally invasive, delivering therapeutic energy to an accurately defined target without an incision, and has been used to treat a wide variety of pathological conditions, including benign and malignant brain tumors, vascular lesions such as arteriovenous malformations

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Falcone, Germana, Alessandra Perfetti, Beatrice Cardinali, and Fabio Martelli. "Noncoding RNAs: Emerging Players in Muscular Dystrophies." BioMed Research International 2014 (2014): 1–12. http://dx.doi.org/10.1155/2014/503634.

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The fascinating world of noncoding RNAs has recently come to light, thanks to the development of powerful sequencing technologies, revealing a variety of RNA molecules playing important regulatory functions in most, if not all, cellular processes. Many noncoding RNAs have been implicated in regulatory networks that are determinant for skeletal muscle differentiation and disease. In this review, we outline the noncoding RNAs involved in physiological mechanisms of myogenesis and those that appear dysregulated in muscle dystrophies, also discussing their potential use as disease biomarkers and t

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Halperin, Jeffrey M. "An Introduction to Human Neuropsychology: Principles of Neuropsychology, by E.A. Zillmer and M.V. Spiers. 2001. Belmont, CA: Wadsworth/Thomson Learning. 606 pp., $86.95 (HB)." Journal of the International Neuropsychological Society 9, no. 3 (2003): 499–500. http://dx.doi.org/10.1017/s1355617703253157.

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Education and training in neuropsychology has been primarily directed to pre- and postdoctoral students with numerous excellent books available for these target audiences. However, as indicated by Eric Zillmer in the preface to Principles of Neuropsychology, this book is geared toward undergraduates and beginning-level graduate students, a group that in this reviewer's opinion, has received considerably less attention from the field. According to Dr. Zillmer, the goal was to “teach brain function in a clear, interesting and progressive manner.” This goal was clearly accomplished by the authors

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Javaherian, Mohammad, and Seyyed Jafar Saghanezhad. "Synthesis, Characterization and Applications of Dicationic Ionic Liquids in Organic Synthesis." Mini-Reviews in Organic Chemistry 17, no. 4 (2020): 450–64. http://dx.doi.org/10.2174/1570193x16666190508091231.

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Dicationic ionic liquids are an emerging group of Ionic Liquids (ILs) that are currently receiving much attention as green reaction media and catalysts. Because of a great number of possible combinations of cations and anions, the physical and chemical properties of dicationic ionic liquids are more tunable and broader than monocationic ILs. Therefore, their unique properties have made them the target of many applied and fundamental researches. Actually, dicationic ionic liquids are more effective and rather fascinating than traditional monocationic ILs. So, due to greater versatility and dive

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Claps, Francesco, and M. Carmen Mir. "Novel Expanding Renal Cell Carcinoma Biomarkers." Société Internationale d’Urologie Journal 2, no. 1 (2021): 32–42. http://dx.doi.org/10.48083/xlqz8269.

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Identification of reliable molecular biomarkers that can complement clinical practice represents a fascinating challenge in any cancer field. Renal tumors are usually asymptomatic and incidentally identified during imaging studies undertaken for unrelated causes. However, in 25% to 30% of patients the first diagnosis is accompanied by symptoms and associated with distant metastasis. Thus, early diagnosis may reduce the risk of disease progression also avoiding side effects of inadequate treatments. Moreover, the ability to categorize patients' risk of recurrence after radical treatment, or eve

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Park, Ji Young, Kisang Park, Gyeongsik Ok, et al. "Detection of Escherichia coli O157:H7 Using Automated Immunomagnetic Separation and Enzyme-Based Colorimetric Assay." Sensors 20, no. 5 (2020): 1395. http://dx.doi.org/10.3390/s20051395.

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The food industry requires rapid and simple detection methods for preventing harm from pathogenic bacteria. Until now, various technologies used to detect foodborne bacteria were time-consuming and laborious. Therefore, we have developed an automated immunomagnetic separation combined with a colorimetric assay for the rapid detection of E. coli O157:H7 in food samples. The colorimetric detection method using enzymatic reaction is fascinating because of its simplicity and rapidity and does not need sophisticated devices. Moreover, the proposed procedures for the detection of bacteria in food ta

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Zeth, Kornelius, and Enea Sancho-Vaello. "Structural Plasticity of LL-37 Indicates Elaborate Functional Adaptation Mechanisms to Bacterial Target Structures." International Journal of Molecular Sciences 22, no. 10 (2021): 5200. http://dx.doi.org/10.3390/ijms22105200.

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The human cathelicidin LL-37 is a multifunctional peptide of the human innate immune system. Among the various functions of LL-37, its antimicrobial activity is important in controlling the microorganisms of the human body. The target molecules of LL-37 in bacteria include membrane lipids, lipopolysaccharides (LPS), lipoteichoic acid (LTA), proteins, DNA and RNA. In this mini-review, we summarize the entity of LL-37 structural data determined over the last 15 years and specifically discuss features implicated in the interactions with lipid-like molecules. For this purpose, we discuss partial a

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Fortunato, Orazio, and Marilena V. Iorio. "The Therapeutic Potential of MicroRNAs in Cancer: Illusion or Opportunity?" Pharmaceuticals 13, no. 12 (2020): 438. http://dx.doi.org/10.3390/ph13120438.

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The functional involvement of microRNAs in human neoplasia has raised in the last years an increasing interest in the scientific community toward the potential application in clinics as therapeutic tools. Indeed, the possibility to modulate their expression to re-establish a lost equilibrium and counteract tumor growth and dissemination, and/or to improve responsiveness to standard therapies, is promising and fascinating. However, several issues need to be taken into account such as factors related to miRNA stability in the blood, tissue penetration and potential off-target effects, which migh

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Glawion, Dorit. "Radio Galaxies at TeV Energies: Preface." Galaxies 8, no. 1 (2020): 18. http://dx.doi.org/10.3390/galaxies8010018.

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The majority of the known extragalactic sky from TeV gamma-ray energies consists of blazars having plasma jets pointing in the direction of the line-of-sight, which results in a large Doppler boosting of their emission. Up to now, only six galaxies with a larger viewing angle have been detected in the TeV range. These objects also show fascinating properties, such as fast variability or spectral features and are called “radio galaxies”. The TeV radio galaxies provide a unique laboratory for studying key aspects of active galactic nuclei. This Special Issue of Galaxies targets these exciting ob

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Ulrych, Tadeusz J. "The whiteness hypothesis: Reflectivity, inversion, chaos, and Enders." GEOPHYSICS 64, no. 5 (1999): 1512–23. http://dx.doi.org/10.1190/1.1444655.

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The earth’s reflectivity is one of the principal targets of seismic exploration for oil and gas. It exhibits some fascinating properties. It is blue. It is fractal. In all probability, it reflects the output of a chaotic generator. I examine some of these characteristics here. Specifically, I look at the statistical properties of a canonical chaotic model, and I examine the effect of multiples on the statistical properties of seismograms generated from primary reflectivities. This article is a tribute to Enders Robinson. He is a pioneer who has inspired many. He inspires many to this day. I am

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Abbas, Touqeer, Muhammad Amir Aslam ., and Muhammad Waqas . "Analyzing the Efficiency Differences among Basic Health Units in Sargodha District." Journal of Economics and Behavioral Studies 3, no. 1 (2011): 42–50. http://dx.doi.org/10.22610/jebs.v3i1.254.

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Pakistan has adequate infrastructure for health services delivery at primary level. The study aims to calculate the technical efficiency of Basic Health Units (BHUs) in Sargodha by using the Data Envelopment Analysis (DEA) with the choice of inputs and outputs being specific to BHUs operation. DEA model results reveals that the mean technical efficiency under, Constant Returns to Scale (CRS) and Variable Returns to Scale (VRS) was 0.719 and 0.807 while the mean scale efficiency was 0.88. Study exposed that 77 % BHUs were technically inefficient under CRS while 66 % BHUs were technically ineffi

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Golder, Matthew R., Lev N. Zakharov, and Ramesh Jasti. "Stereochemical implications toward the total synthesis of aromatic belts." Pure and Applied Chemistry 89, no. 11 (2017): 1603–17. http://dx.doi.org/10.1515/pac-2017-0413.

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AbstractThe synthesis of carbon nanotube (CNT) fragments has long captivated organic chemists, despite the simplistic, symmetric nature of the requisite achiral targets. Such molecules hold the potential to allow for the synthesis of homogeneous CNTs, rendering their properties more suitable for advanced applications in electronics and sensing. The [n]cycloparaphenylene family, comprised of molecules with para-linked phenyl rings in a contiguous macrocycles, represents a major landmark towards achieving absolute control of CNT architecture from the bottom-up. Attempts towards accessing the [n]

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Giammalva, Giuseppe Roberto, Cesare Gagliardo, Salvatore Marrone, et al. "Focused Ultrasound in Neuroscience. State of the Art and Future Perspectives." Brain Sciences 11, no. 1 (2021): 84. http://dx.doi.org/10.3390/brainsci11010084.

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Transcranial MR-guided Focused ultrasound (tcMRgFUS) is a surgical procedure that adopts focused ultrasounds beam towards a specific therapeutic target through the intact skull. The convergence of focused ultrasound beams onto the target produces tissue effects through released energy. Regarding neurosurgical applications, tcMRgFUS has been successfully adopted as a non-invasive procedure for ablative purposes such as thalamotomy, pallidotomy, and subthalamotomy for movement disorders. Several studies confirmed the effectiveness of tcMRgFUS in the treatment of several neurological conditions,

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Bullock, Katherine. "The Veil Unveiled." American Journal of Islam and Society 19, no. 4 (2002): 118–21. http://dx.doi.org/10.35632/ajis.v19i4.1900.

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Finally, the study ofhijab has come of age. After Shirazi's book, no one willbe able to argue that "the" hijab means any one thing divorced from its context.In six chapters, Shirazi investigates the "semantic versatility of theveil" in western popular culture, Saudi advertising, Iranian and Indian poetryand films, and for Iranian, Iraqi, and UAE women soldiers. Not surprisingly,the veil means different things in different contexts, and Shirazi'sbook is a rich study of this diversity. She reinforces her arguments by thewealth of photographs that depict veiled women in multiple contexts.Just how

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