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Dissertations / Theses on the topic 'Target markers'

Author: Grafiati

Published: 28 May 2022

Last updated: 30 July 2025

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1

Di, Stefano Anna Luisa. "Molecular markers of gliomas : implications for diagnosis and new target therapies." Thesis, Paris 6, 2017. http://www.theses.fr/2017PA066015.

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Le travail de thèse est dédié à la caractérisation de fusions spécifiques oncogéniques entre les gènes FGFR et TACC dans les gliomes. Nous avons analysé 907 gliomes pour la présence du gène de fusion FGFR3-TACC3. Nous avons montré que les fusions FGFR3-TACC3 ne touchent que les gliomes IDH wild-type (3%), sont mutuellement exclusives avec l'amplification de EGFR et avec la forme tronquée EGFRvIII et inversement, sont associées à l'amplification de CDK4 et de MDM2 et à la délétion du 10q. Les fusions FGFR3-TACC3 sont associées à une expression intense et diffuse de FGFR3 en immunohistochimie (I

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DI, STEFANO ANNA LUISA. "MOLECULAR MARKERS OF GLIOMAS Implications for diagnosis and new target therapies." Doctoral thesis, Università degli studi di Pavia, 2017. http://hdl.handle.net/11571/1203374.

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The 2016 WHO classification of gliomas integrates molecular alterations (ie IDH mutations, and 1p19q codeletion) to histological features, defining distinct histo-molecular entities: IDH wild-type gliomas (mostly glioblastomas), and IDH mutated gliomas, divided according to 1p19q status into astrocytomas (1p19q intact) and oligodendrogliomas (1p19q codeleted). The first part of the manuscript is a contribution to molecular classification based on TERT promoter mutational status. We also contributed to GWAS analysis, and investigated the association between the risk loci and specific molecular

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Ngqwala, Nosiphiwe Patience. "Interaction of metallic nanoparticles with biomedical enzyme target: neuronal nitric oxide synthase." Thesis, Rhodes University, 2013. http://hdl.handle.net/10962/d1001536.

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Alzheimer's disease (AD) is the most common type of dementia characterized by intracellular appearance of neurofibrillary tangles, synaptic and neuronal loss; and extracellular accumulation of amyloid-β (Aβ) peptide in senile plaques. The initial causes leading to AD are unknown, and the available treatments are only effective at slowing the degeneration process. The accumulation of arginine in the brain of Alzheimer patients indicates a possible disruption of enzymes responsible for its metabolism. One such enzyme is neuronal nitric oxide synthase (nNOS) and controlling its activity by intera

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4

Fiengo, Lorenzo. "Target-based study to identify new bioactive diterpenes." Doctoral thesis, Universita degli studi di Salerno, 2019. http://elea.unisa.it:8080/xmlui/handle/10556/4500.

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2017 - 2018<br>Target identification and mechanism of action studies of plant-derived compounds play a critical role in drug discovery. The knowledge of the bioactivity of natural compounds can lead to a number of advantages: first of all, it is possible to understand their full therapeutic potential; in addition, it can allow the further identification of their side-effects, their toxicity and also structure-activity relationships studies. This research project is focused on a Reverse Chemical Genetics approach, which relies on the screening of libraries of plant small molecules (provided by

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Fryknäs, Mårten. "Molecular screening for target discovery in cancer /." Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7086.

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6

McNeeley, Kathleen Margaret. "Modulating liposomal stealth properties to evade RES and target tumors." Diss., Atlanta, Ga. : Georgia Institute of Technology, 2008. http://hdl.handle.net/1853/26650.

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Thesis (Ph.D)--Biomedical Engineering, Georgia Institute of Technology, 2009.<br>Committee Chair: Ravi V. Bellamkonda; Committee Member: Ananth V. Annapragada; Committee Member: Andrew Lyon; Committee Member: Gang Bao; Committee Member: Niren Murthy. Part of the SMARTech Electronic Thesis and Dissertation Collection.

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Ek, Cecilia. "Lost and gained in translation : Pragmatic markers in an English source text andits Swedish target text." Thesis, Linnéuniversitetet, Institutionen för språk (SPR), 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-65437.

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This study analyses the translation of some pragmatic markers in an informal English non-fiction text and its Swedish target text. The pragmatic markers in focus are interjections, modal adverbs and question tags, and the sources of the Swedish modal particle ju are also analysed. While pragmatic markers are more common in spoken language or fiction, in this case they were considered important to the interpersonal function and casual style of the non-fiction text. The results were also compared to data from a non-fiction parallel corpus. In total, the ST contained 31 of the selected types of p

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8

Morató, Arús Xavier. "GPR37-ADENOSINE A2A receptor-receptor interaction as a new pharmacological target for Parkinson’s disease treatment." Doctoral thesis, Universitat de Barcelona, 2017. http://hdl.handle.net/10803/457874.

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GPR37 is an orphan GPCR that belongs to the Rodhopsin family. GPR37 is highly expressed in the Central Nervous System (CNS), while little peripheral expression has been found in humans and rodents. GPR37 is highly distributed in the brain, particularly at the cerebellum, corpus callosum, substantia nigra, striatum and hippocampus with a predominantly neuronal distribution. However, the function of this receptor in the CNS remains unknown. The interest on GPR37 biology was bolstered when it was described as a Parkin substrate. GPR37 was isolated from a human brain library in a yeast 2-hybrid sc

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9

CORPORA, Francesca. "EFFETTI DELLA DIETA MEDITERRANEA SUGLI INDICI DI DISFUNZIONE ENDOTELIALE, SULL'ESPRESSIONE SIERICA DEI MARKERS ADIPO-INFIAMMATORI E DEL PATTERN CERAMIDICO E SULLA MODULAZIONE EPIGENOMICA DEI POLIMORFISMI TARGET." Doctoral thesis, Università degli Studi di Palermo, 2021. http://hdl.handle.net/10447/477942.

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Background Le attuali conoscenze evidenziano il ruolo cruciale della dieta mediterranea nella prevenzione delle malattie cardiovascolari. A tal proposito, negli ultimi decenni, diversi studi e alcuni trial randomizzati di intervento dietetico, come lo studio Lyon diet heart study, hanno riportato gli effetti benefici dello stile mediterraneo sulla prevenzione secondaria delle malattie cardiovascolari Lo studio PREDIMED è il primo studio randomizzato su su larga scala che mostra l'impatto significativo della dieta mediterranea come strumento di prevenzione primaria contro eventi cardiovascolar

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10

Thakkar, Dipti S. "Telomerase : a prognostic marker and therapeutic target." Thesis, University of Central Lancashire, 2010. http://clok.uclan.ac.uk/1872/.

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Malignant glioma is the most common and aggressive form of tumours and is usually refractory to therapy. Telomerase and its altered activity, distinguishing cancer cells, is an attractive molecular target in glioma therapeutics. The aim of this thesis was to silence telomerase at the genetic level with a view to highlight the changes caused in the cancer proteome and identify the potential downstream pathways controlled by telomerase in tumour progression and maintenance. A comprehensive proteomic study utilizing 2D-DIGE and MALDI-TOF were used to assess the effect of inhibiting two different

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11

Varghese, Robin. "Novel Prognostic Markers and Therapeutic Targets for Glioblastoma." Diss., Virginia Tech, 2016. http://hdl.handle.net/10919/71420.

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Glioblastoma is the most common and lethal malignant brain tumor with a survival rate of 14.6 months and a tumor recurrence rate of ninety percent. Two key causes for glioblastomas grim outcome derive from the lack of applicable prognostic markers and effective therapeutic targets. By employing a loss of function RNAi screen in glioblastoma cells we found a list of 20 kinases that can be considered glioblastoma survival kinases. These survival kinases which we term as survival kinase genes, (SKGs) were investigated to find prognostic markers as well as therapeutic targets for glioblastoma. Ana

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Pigini, Paolo <1991&gt. "Neuroblastoma targeted therapy: employment of CRISPR gene-editing to explore relevant markers and potential targets in aggressive tumours." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2019. http://amsdottorato.unibo.it/8752/1/Pigini_Paolo_tesi.pdf.

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Neuroblastoma is a tumour originating from the sympathetic nervous system, and represents the most common extracranial solid cancer in childhood. Despite the malignancy is extremely heterogeneous, about 25% of all cases is characterized by MYCN-gene amplification, aggressive tumour and poor survival. The network of genes that are deregulated in this group of patients represents a focal point for targeted-therapy discovery. Along this research line, the first objective of the present project was to investigate the prognostic significance of a single nucleotide polymorphism (SNP) located in the

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13

BERZERO, GIULIA. "“MOLECULAR MARKERS IN DIFFUSE GLIOMAS: DIAGNOSTIC AND THERAPEUTIC TARGETS”." Doctoral thesis, Università degli studi di Pavia, 2020. http://hdl.handle.net/11571/1371676.

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Due to their capital diagnostic, prognostic and therapeutic implications, molecular markers have become essential for the management of patients with diffuse gliomas. Among them, IDH mutations have special importance, as they allow to classify diffuse gliomas, they are predictive of prolonged survival and increased sensitivity to alkylating agents and can be targeted by specific inhibitors. IDH-mutant diffuse gliomas deeply differ from IDH-wildtype diffuse gliomas in terms of molecular profile, prognosis and treatment, as different are the pathways of gliomagenesis and progression in the two g

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Bartrolí, Comellas Mariona. "Prognostic markers and therapeutic targets for metastatic renal cell carcinoma." Doctoral thesis, Universitat de Barcelona, 2018. http://hdl.handle.net/10803/664198.

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Targeting cancer metastasis has gained considerable importance in the recent years when aiming to increase patients’ overall survival. In Renal Cell Carcinoma (RCC), the discovery of metastatic biomarkers and targets is still required, as most patients present metastatic disease at the time of diagnosis. Therefore, the aim of this thesis is the discovery of new biomarkers and targets of metastatic RCC using two variants of a patient-derived orthoxenograft (PDOX) animal model of clear cell RCC (ccRCC). Indeed, PDOX models have recently gained significant relevance for studying the progressio

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15

Nguyen, Do Quoc Tho Banking &amp Finance Australian School of Business UNSW. "Target interest rate news effects on the Asia pacific financial markets." Publisher:University of New South Wales. Banking & Finance, 2009. http://handle.unsw.edu.au/1959.4/43788.

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This thesis is the first study that provides comprehensive empirical evidence on both the impacts of the target interest rate news from the Reserve Bank of Australia (RBA) on the Australian financial markets, and the spillover effects of the target interest rate news from the US Federal Reserves (Fed) and the European Central Bank (ECB) on the Asia Pacific's equity and currency markets. This thesis contributes to the current literature in several ways. First, while there is ample evidence in the literature suggesting that the markets would not react to what is already expected but will react t

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Tu, Zheng. "DNA replication-initiation proteins : novel cancer detection markers and anticancer targets /." View abstract or full-text, 2004. http://library.ust.hk/cgi/db/thesis.pl?BICH%202004%20TU.

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Richards, Johannes Douglas. "Promotion of a legal firm during recessionary times / Johannes Douglas Richards." Thesis, North-West University, 2010. http://hdl.handle.net/10394/4471.

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Nearly 80 years earlier, Henry Ford advised during the 1930 depression that: "A man who stops advertising to save money is like a man who stops a clock to save time". The purposes of this case study was to determine whether legal firms have taken cognisance of these wise words and have refrained from cutting back on expenses, and more particularly its promotional budget expenses during a down turning economy. It was discovered that, like nearly 80 years ago, costs today is still an important issue when considering and exploreing promotional opportunities. Small legal organisations have in gene

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Brembs, Gunhild. "Dialektelemente in deutscher und schwedischer Literatur und ihre Übersetzung : von Schelch zu eka, von ilsnedu zu bösartig." Doctoral thesis, Stockholms universitet, Tyska institutionen, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-213.

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The present study investigates the translation of dialectal elements in literary texts from the German and Swedish linguistical and cultural areas. Translation theory generally advises against the translation of dialectal elements in standard language texts thereby implicitly questioning their creative and communicative function. The aim of the study is to investigate to what extent the dialectal elements in the source text are translated by corresponding dialectal elements in the target text thereby promoting a "cultural transfer" or whether a translation method based on translation theory is

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19

El, Hajj Petra. "New prognosis markers and new targets for therapy in high risk melanoma: evaluation of TYRP1 as a melanoma prognostic marker and its regulation by miRNA(s)." Doctoral thesis, Universite Libre de Bruxelles, 2015. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209064.

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L’espérance de vie des patients atteints de mélanome à haut risque ne peut être prédite d’une façon<p>fiable en se basant sur les analyses d’histopathologies de la lésion primitive et est souvent ajustée<p>durant la progression de la maladie. Notre étude vise à élargir nos observations initiales au niveau<p>des métastases cutanées et d’évaluer la valeur pronostique de tyrosinase related protein 1 (TYRP1)<p>dans les métastases ganglionnaires des patients atteints de mélanome de stades III et IV. TYRP1 est<p>une enzyme mélanosomale qui partage des similitudes structurelles avec la tyrosinase, l'

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Yildirim-Balatan, Cansu. "Towards the identification of targets and markers of Parkinson’s disease-associated neuroinflammation." Thesis, Sorbonne université, 2021. http://www.theses.fr/2021SORUS442.

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La maladie de Parkinson (MP) est une maladie neurodégénérative caractérisée par l'agrégation de l'α-synucléine (αSYN). Les agrégats αSYN sont essentiels à l'activation de la microglie et aux réponses inflammatoires pouvant contribuer à la pathogenèse. Il est donc important de comprendre les mécanismes qui sous-tendent l'activation, la polarisation et la fonction des cellules microgliales. Dans ce travail, nous avons étudié pour la première fois le potentiel inflammatoire d’assemblages d’αSYN dérivés des patients (FPD) sur la microglie primaire et exploré leur capacité à polariser ces cellules

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Facco, Lorenzo <1995&gt. "AHP and target markets selection: an application to an Italian plastic products company." Master's Degree Thesis, Università Ca' Foscari Venezia, 2019. http://hdl.handle.net/10579/16098.

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Target market selection is a critical decision for companies that desire to internationalise or expand their trade networks. Management and marketing literature highlight the importance of adopting a systematic and data-driven approach to the issue, taking into consideration different criteria such as market size, profitability, presence of competitors, business risk. This aspect assumes particular relevance for SMEs, which often lack the necessary experience and resources to carry out structured market analyses. Analytic Hierarchy Process, the general theory for decision making developed by T

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Miniotis, Maria Falck. "Evaluation of MRS detectable metabolic markers of MEK1/" targeted therapies." Thesis, University of London, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.533141.

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23

EPISTOLIO, SAMANTHA. "Targeted therapies in lung adenocarcinomas: new methodologies and new markers." Doctoral thesis, Università del Piemonte Orientale, 2018. http://hdl.handle.net/11579/103214.

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Il cancro ai polmoni è la patologia neoplastica con il tasso di mortalità più elevato. L’adenocarcinoma (AC), che rappresenta il 60% dei tumori polmonari non a piccole cellule (NSCLC), è l’istotipo più diffuso e attaualmente viene trattato mediante resezione chirurgica combinata con un regime chemioterapico basato su platino (Pt) abbinato ad una coppia di molecole citotossiche. Con lo scopo di risolvere gli svantaggi del trattamento chemioterapico, negli ultimi anni sono stati sviluppati farmaci a bersaglio molecolare. Le terapie molecolari maggiormente utilizzate per gli AC polmonari sono gli

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CUPPINI, LUCIA. "Antiangiogenic therapies for malignant gliomas: new markers for targeted treatment." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2012. http://hdl.handle.net/10281/28473.

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Bevacizumab has shown activity in different tumor types, including high grade gliomas (HGG). However, the use of bevacizumab and other antiangiogenic drugs in the clinical setting limited by the lack of markers to predict responses. We report that the combined treatment with bevacizumab and irinotecan is effective in recurrent HGG patients, particularly in those with local disease, with mild toxicity. Median OS and PFS were 33 and 18 weeks, respectively. PFS at 6 and 12 months were 32% and 12%. OS at 6 months was 60%. Patients with distant intracerebral disease or leptomeningeal dissemination

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Grover, Rajiv. "Oncogene expression in malignant melanoma : markers of prognosis and targets for gene therapy." Thesis, Queen Mary, University of London, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.266579.

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Ong, Chee Wee. "Clinical and molecular characterisation of prognostic markers and therapeutic targets in prostate cancer." Thesis, Queen's University Belfast, 2016. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.709689.

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The increasing advances in genomic technologies in the last decade have allowed us to understand the molecular mutational landscape of prostate cancer. However, validation of genomic profiles generated by high-throughput efforts is laborious and expensive. Therefore, there is a need for a systematic and streamlined assessment of high-throughput genomic data to prioritise genes for further detailed biological validation studies for which this thesis entailed. Through cluster analysis of a panel of carefully selected markers, such as AR, ERG, MYC, RB1, PTEN and TP53, we were able to align patien

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Thomas, Hardy Mathew. "The markets for corporate control in the UK : takeover target selection in the official list and in the unlisted securities markets." Thesis, University of Ulster, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.240994.

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Kressner, Josephine D. "Leveraging targeted marketing data in travel demand modeling: validation and applications." Diss., Georgia Institute of Technology, 2014. http://hdl.handle.net/1853/51870.

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To date, the collection of comprehensive household travel data has been a challenge for most metropolitan planning organizations (MPOs) and state departments of transportation (DOTs) due mainly to high costs. Urban population growth, the expansion of metropolitan regions, and the general unwillingness of the public to complete surveys conflict with limited public funds. The purpose of this research is to leverage targeted marketing data, sometimes referred to as consumer data or just simply marketing data, for travel demand modeling applications. This research reveals a first step in exploring

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Pozzi, Valentina. "L'enzima nicotinamide N-Metiltrasferasi: un nuovo marker diagnostico e target terapeutico nel carcinoma orale." Doctoral thesis, Università Politecnica delle Marche, 2011. http://hdl.handle.net/11566/241870.

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Il carcinoma squamocellulare (OSCC) rappresenta la lesione neoplastica più frequente nella cavità orale. Nonostante i progressi effettuati in campo sia chirurgico sia terapeutico, la sopravvivenza media a 5 anni si mantiene ancora al di sotto del 50%. La ricerca di marcatori molecolari coinvolti nella progressione neoplastica risulta essere quindi di primaria importanza. In relazione a studi precedentemente condotti, che hanno portato all’identificazione dell’enzima Nicotinamide N-metiltrasferasi (NNMT) quale potenziale marker di alcune tipologie di tumore, è risultato interessante intrapren

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Hammarsten, Peter. "Androgen controlled regulatory systems in prostate cancer : potential new therapeutic targets and prognostic markers." Doctoral thesis, Umeå : Umeå University, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1930.

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Buchta, Christian, Sara Dolnicar, Roman Freitag, et al. "Is thinking worthwhile? A comparison of corporate segment choice strategies." SFB Adaptive Information Systems and Modelling in Economics and Management Science, WU Vienna University of Economics and Business, 2003. http://epub.wu.ac.at/750/1/document.pdf.

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The field of strategic marketing has long been identified as fruitful ground for gaining competitive advantage. Ever since the market segmentation concept was introduced in the late sixties, research interest steadily increased, covering issues as e.g. which fundamental segmentation strategy is most appropriate, in which ways can segments be identified or constructed, which algorithm provides optimal data-driven segmentation solutions, which number of segments should be constructed etc.. Interestingly, the issue of segment evaluation and choice has not been emphasised very strongly in the past

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Briglauer, Wolfgang, Volker Stocker, and Jason Whalley. "Public Policy Targets in EU Broadband Markets: The Role of Technological Neutrality." Forschungsinstitut für Regulierungsökonomie, WU Vienna University of Economics and Business, 2019. http://epub.wu.ac.at/6773/1/Briglauer_Whalley_Stocker.pdf.

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The European Commission has recently sought to substantially revise how it regulates the telecommunication industry, with a key goal being to incentivise investment in high-speed broadband networks. Ambitious goals to incentivise investment in high-speed broadband networks have been set across the European Union, initially in the "Digital Agenda for Europe" and more recently in its "Gigabit strategy". These goals reflect the view of many that there are widespread and significant socio-economic benefits associated with broadband. Our analysis explores the consequence of target setting at a Euro

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Idenfors, Evelinn, and Jennie Kjellin. "Customer value in a B2B setting : An analysis of potential target markets for the rehabilitation company Svenska-Re." Thesis, Umeå universitet, Företagsekonomi, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-58118.

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This study aims to investigate potential B2B customer segments in Umeå concerning company-wellness and rehabilitation services. We will investigate the market, identify a prospect target market and evaluate this target market on commission from Svenska-Re. The company Svenska-Re offers a service where customers travel to Gran Canaria, Spain, for a three week rehabilitation program. They offer various programs and are specialized in work-related injuries. By evaluating the target market we will investigate if there is an interest and need of the services provided by Svenska-Re in Umeå.

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Sallaberry, Pinto Júlia. "Novel markers and targets of collective tumor cell invasion before and after anti-angiogenic therapies." Doctoral thesis, Universitat de Barcelona, 2019. http://hdl.handle.net/10803/666666.

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Local invasion is a key cell-biological event in the metastatic cascade. In response to a changing microenvironment, cancer cells may act using two main strategies of invasion: single cell invasion and collective invasion. Determining how tumor cells initiate and sustain local invasive behavior might help to improve patient diagnosis and lead to the development of new intervention modalities. Therefore, the aim of this thesis is to elucidate which molecular mechanisms are involved in PanNETs invasion before and after anti-angiogenic therapies. Results from our group have demonstrated an irr

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Kojima, Kyoko. "Mouse modeling of pancreatic ductal adenocarcinoma (PDAC) search for early diagnostic markers and therapeutic targets /." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2009. https://www.mhsl.uab.edu/dt/2009p/kojima.pdf.

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Duan, Yufeng. "Ex-post competitiveness assessment of Alberta agri-food exports in target products and markets, 1988-1996." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0019/MQ47022.pdf.

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Güttler, Antje [Verfasser]. "Osteopontin als endogener Marker der Tumorhypoxie und therapeutisches Target in der Strahlentherapie : [kumulative Dissertation] / Antje Güttler." Halle, 2017. http://d-nb.info/1129685535/34.

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Di, Ruscio Giulia. "L'enzima Nicotinamide N-metiltrasferasi: un nuovo marker diagnostico e target terapeutico nel carcinoma uroteliale della vescica." Doctoral thesis, Università Politecnica delle Marche, 2016. http://hdl.handle.net/11566/242514.

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L’enzima nicotinamide N-metiltrasferasi: un nuovo marker diagnostico e target terapeutico del carcinoma uroteliale della vescica Il carcinoma uroteliale della vescica è uno dei tumori urologici di più frequente riscontro e rappresenta un’impostante causa di morte per cancro. Sebbene la cistoscopia e l’analisi citologica del sedimento urinario costituiscano il "gold standard" per la diagnosi e il monitoraggio di tale tumore, entrambe le procedure presentano dei limiti. Pertanto, risulta di fondamentale importanza l’identificazione di biomarcatori che possano impiegati per la diagnosi precoce e

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Verset, Laurine. "Cancer-associated fibroblasts and FHL2 protein as prognostic markers and possible therapeutic targets in colorectal cancer." Doctoral thesis, Universite Libre de Bruxelles, 2016. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/237291.

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Les tumeurs sont constituées de deux groupes cellulaires :les cellules tumorales et les cellules dites « hôtes ». Au sein de ce dernier groupe, on retrouve les cellules endothéliales, les cellules inflammatoires mais également les fibroblastes associés au cancer (FAC). De plus en plus de données dans la littérature suggèrent l’importance des FAC dans l’invasion tumorale et le développement métastatique. De nombreuses études immunohistochimiques ont démontré le rôle pronostique des FAC dans différents cancers. Les traitements néoadjuvants modifient l’environnement tumoral mais l’impact de ces t

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McIntyre, Alan Joseph. "Identifying potential markers and targets for therapy in testicular germ cell tumours of adolescents and adults." Thesis, Institute of Cancer Research (University Of London), 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.434349.

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Miyagi, Mikiko. "Exploitation of bacterial artificial chromosome (BAC) libraries to enhance the efficiency of genome mapping." Thesis, Queensland University of Technology, 2002. https://eprints.qut.edu.au/37140/6/37140_Digitised%20Thesis.pdf.

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De, Jager Nedia. "The living standards measure as a market segmentation tool for selected retailers / by Nedia de Jager." Thesis, North-West University, 2004. http://hdl.handle.net/10394/692.

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Businesses have realised that they cannot appeal to all consumers in the marketplace. Consumers are too numerous, geographically wide-spread, and too varied in their needs and buying practices. Furthermore, the business& themselves vary widely in their abilities to serve different segments of the market. Businesses consequently conduct market segmentation to identify the parts of the market that it can best serve and most profitably. Therefore, the goal of this study was to determine the actual target markets of selected retailers by means of the Living Standards Measure (LSM) tool, and to rec

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Hill, Mark Edwin. "Bcl-2 as a prognostic marker and potential target for antisense oligonucleotide therapy of non-Hodgkin's lymphoma." Thesis, St George's, University of London, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.243569.

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Huggett, M. T. "The use of novel diagnostic cell cycle markers and targeted treatment of pancreaticobiliary cancers." Thesis, University College London (University of London), 2014. http://discovery.ucl.ac.uk/1433745/.

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Adenocarcinoma of the pancreas is one of the top ten leading causes of cancer deaths. In the UK approximately 8000 people are diagnosed with the disease each year. Surgical resection is the only chance of cure and is only possible in a minority of patients. Even after resection, median survival is only 10–20 months and no more than 5–20% of resected patients survive five years. Earlier diagnostic assays and novel treatments are urgently required to improve outcomes. Chapter 1 summarises clinical aspects of pancreatic cancer and current diagnostic and prognostic tests. Chapter 2 gives an introd

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Brabez, Nabila. "Design, Synthesis and Study of Novel Multivalent Ligands - Toward New Markers of Cancer Cells." Diss., The University of Arizona, 2012. http://hdl.handle.net/10150/238691.

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Cancer is lacking early detection methods and treatment specificity. In order to increase the sensitivity and specificity towards cancer cells, we propose the use of multivalent interactions targeting specific receptor combinations at the cancer cell surface. In this thesis, we explored the design of multimers, which could provide such interactions. The design was investigated and revisited based on specific parameters, essential for the creation of multivalent interactions such as thermodynamics. The synthesis was designed so that libraries of homo- and hetero-multimers of different valencies

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Криса, А. В. "Дослідження та визначення цільового ринку (на матеріалах ТОВ «Виробничо-комерційна фірма «ВВ»)". Thesis, Чернігів, 2020. http://ir.stu.cn.ua/123456789/20686.

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Криса, А. В. Дослідження та визначення цільового ринку (на матеріалах ТОВ «Виробничо-комерційна фірма «ВВ») : магістерська робота : 075 Маркетинг / А. В. Криса ; керівник роботи Рябова Т. А. ; Національний університет «Чернігівська політехніка», кафедра маркетингу, PR-технологій та логістики. – Чернігів, 2020. – 73 с.<br>У випускній кваліфікаційній роботі розглянуто процес дослідження та визначення цільового ринку на ринку канцелярських товарів. Випускна кваліфікаційна робота містить такі розділи: - теоретичні основи процесу дослідження цільового ринку; - аналіз діяльності ТОВ “ВКФ “ВВ”;

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Özcan, Sebahattin. "Tissue culture in pea and engineering a marker gene for specific expression in target cells for plant transformation." Thesis, University of Leicester, 1993. http://hdl.handle.net/2381/35334.

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Noudomi, Seishiro. "CD146 is a novel marker for highly tumorigenic cells and a potential therapeutic target in malignant rhabdoid tumor." Kyoto University, 2016. http://hdl.handle.net/2433/217140.

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Pasello, Giulia. "RESEARCH OF PREDICTIVE AND PROGNOSTIC TISSUE AND MOLECULAR MARKERS AND OF NEW THERAPEUTIC TARGETS IN MALIGNANT PLEURAL MESOTHELIOMA." Doctoral thesis, Università degli studi di Padova, 2015. http://hdl.handle.net/11577/3423950.

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BACKGROUND: Malignant pleural mesothelioma (MPM) is an aggressive tumor with increasing incidence in industrialized countries, because of previous widespread asbestos exposure and long latency time before symptoms appearance. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) belongs to the tumor necrosis factor (TNF) family of death ligands; it was identified as a promising anticancer agent thanks to its property of killing cancer cells while sparing normal cells. Conflicting evidences about MPM resistance rather than sensitivity to TRAIL-induced apoptosis were previously reporte

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Yang, Kundi. "Assessing and Evaluating Biomarkers and Chemical Markers by Targeted and Untargeted Mass Spectrometry-based Metabolomics." Miami University / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=miami1605044640528563.

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