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Dissertations / Theses on the topic 'Target products'

Author: Grafiati

Published: 30 May 2022

Last updated: 31 July 2025

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1

Carlsson-Wall, Martin. "Targeting target costing : cost management and inter-organizational product development of multi-technology products." Doctoral thesis, Handelshögskolan i Stockholm, Institutionen för Redovisning och finansiering, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:hhs:diva-1284.

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Improving product development is a complex task for many companies. One challenge is to avoid over-engineering and only include the functionality that customers are willing to pay for. Another challenge is to reduce costs in close co-operation with suppliers. This is a complex task because suppliers often have their own goals and are rarely located at the same physical place. Handling these two challenges is the domain of target costing. Emerging first from Japanese companies such as Toyota, Nissan and Olympus, target costing has become a critical element in achieving long-term profitability.

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2

Mohammed, Asjad Kaleem. "Anticancer natural products that target hypoxia-inducible factor-1 /." Full text available from ProQuest UM Digital Dissertations, 2005. http://0-proquest.umi.com.umiss.lib.olemiss.edu/pqdweb?index=0&did=1260789291&SrchMode=1&sid=4&Fmt=2&VInst=PROD&VType=PQD&RQT=309&VName=PQD&TS=1185218250&clientId=22256.

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3

Fraser, Andrew Logan. "Target elucidation of novel trypanosomatid inhibitors." Thesis, University of St Andrews, 2018. http://hdl.handle.net/10023/15666.

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In 2010 the Florence group completed the total synthesis of the natural product chamuvarinin which, in collaboration with the Smith group, was found to be a potent inhibitor of the pathogenic parasite T. brucei. Several simplified analogues were found to maintain this inhibitory activity alongside activity against the related species T. cruzi and L. major. The mechanism of action and structural features of these compounds responsible for the observed biological activity remained elusive despite a large synthetic effort by the Florence group. With the aim of identifying protein targets in trypa

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4

Yan, Luping. "Bioactive marine natural products : analogue synthesis, SAR, and target identification." Thesis, University of British Columbia, 2014. http://hdl.handle.net/2429/50069.

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3,6,7-trihydroxycoumarin C11 (2.14) was first isolated from the green alga Dasycladus vermicularis in 1983. C11 and 3,7,8-trihydroxycoumarin C21 (2.15), alongside their precursors C12 (2.18) and C22 (2.20), were synthesized for a target-based screen for anti-HCV drugs, where ideal hits eliminate fluorescence signals by inhibiting the proteolytic activity of HCV NS3pro/Pep4A against a synthetic peptide “BS-IQFS”. With C12 and C22 serving as negative controls, C11 and C21 inhibited the NS3pro/Pep4A activity in vitro. The IC₅₀’s of C11 and C21 were 3.07 μM and 2.10 μM, respectively. A bioassay-g

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5

Facco, Lorenzo <1995&gt. "AHP and target markets selection: an application to an Italian plastic products company." Master's Degree Thesis, Università Ca' Foscari Venezia, 2019. http://hdl.handle.net/10579/16098.

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Target market selection is a critical decision for companies that desire to internationalise or expand their trade networks. Management and marketing literature highlight the importance of adopting a systematic and data-driven approach to the issue, taking into consideration different criteria such as market size, profitability, presence of competitors, business risk. This aspect assumes particular relevance for SMEs, which often lack the necessary experience and resources to carry out structured market analyses. Analytic Hierarchy Process, the general theory for decision making developed by T

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Oselusi, Samson Olaitan. "Cheminformatic approaches to hit-prioritization and target prediction of potential anti-mrsa natural products." University of Western Cape, 2020. http://hdl.handle.net/11394/8209.

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Magister Pharmaceuticae - MPharm<br>The growing resistance of Methicillin-Resistant Staphylococcus aureus (MRSA) to currently prescribed drugs has resulted in the failure of prevention and treatment of different infections caused by the superbug. Therefore, to keep pace with the resistance, there is a pressing need for novel antimicrobial agents, especially from non-conventional sources. Several natural products (NPs) have displayed varying in vitro activities against the pathogen but few of these natural compounds have been studied for their prospects to be potential antimicrobial drug candid

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7

Centko, Ryan Matthew. "Isolation, synthesis, and biological target identification of natural products from terrestrial and marine environments." Thesis, University of British Columbia, 2014. http://hdl.handle.net/2429/50064.

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Natural products offer an unparalleled resource for the discovery and development of chemical tools to be used by humans. The terrestrial and marine environments contain unique niches where organisms chemically adapt to produce compounds that have proven useful medicinally and beyond. In the following chapters, several classes of novel natural products from terrestrial fungi and marine sponges will be presented. In some cases, synthetic methodology, biological activity and enzymatic target identification will also be presented. Chapters 2 and 3 highlight ramariolides A–D (2.18–2.21)

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8

Horton, Kevin G. "The use of portfolio management with target costed process oriented products under conditions of uncertainty." Master's thesis, This resource online, 1995. http://scholar.lib.vt.edu/theses/available/etd-02022010-020227/.

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9

Baldo, Fatima Magdi Hamza. "Integrating chemical, biological and phylogenetic spaces of African natural products to understand their therapeutic activity." Thesis, University of Cambridge, 2019. https://www.repository.cam.ac.uk/handle/1810/289714.

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This research aims to utilise ligand-based target prediction to (i) understand the mechanism of action of African natural products (ANPs), (ii) help identify patterns of phylogenetic use in African traditional medicine and (iii) elucidate the mechanism of action of phenotypically active small molecules and natural products with anti-trypanosomal activity. In Chapter 2 the objective was to utilise ligand-based target prediction to understand the mechanism of action of natural products (NPs) from African medicinal plants used against cancer. The Random Forest classifier used in this work compare

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10

Duan, Yufeng. "Ex-post competitiveness assessment of Alberta agri-food exports in target products and markets, 1988-1996." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0019/MQ47022.pdf.

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11

Heuett, Nubia Vanesa. "Target and Non-target Techniques for the Quantitation of Drugs of Abuse, Identification of Transformation Products, and Characterization of Contaminants of Emergent Concern by High Resolution Mass Spectrometry." FIU Digital Commons, 2015. http://digitalcommons.fiu.edu/etd/2194.

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Development and application of target and non-target techniques for routine analysis, identification of transformation products, and characterization of unknown compounds in water matrices using liquid-chromatography high-resolution mass spectrometry (HRMS) were explored in this dissertation. A novel analytical method based on online-SPE-LC-HRMS was developed for the detection of 18 drugs of abuse (DOAs) in raw sewage water from a college campus. Results showed the presence of 14 DOAs for which amphetamine and 11-nor-9-carcoxy-THC (THC metabolite) were the most prevalent and had the highest po

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12

Li, Zhe. "Fate of Pharmaceuticals and Their Transformation Products in Rivers : An integration of target analysis and screening methods to study attenuation processes." Doctoral thesis, Stockholms universitet, Institutionen för miljövetenskap och analytisk kemi, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-123752.

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Pharmaceuticals are environmental contaminants causing steadily increasing concern due to their high usage, ubiquitous distribution in the aquatic environment, and potential to exert adverse effects on the ecosystems. After being discharged from wastewater treatment plants (WWTPs), pharmaceuticals can undergo transformation processes in surface waters, of which microbial degradation in river sediments is considered highly significant. In spite of a substantial number of studies on the occurrence of pharmaceuticals in aquatic systems, a comprehensive understanding of their environmental fate is

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13

Zhang, Wei, Xue Zhang, Yuling Tian, et al. "Risk Assessment of Total Mercury and Methylmercury in Aquatic Products from Offshore Farms in China." Digital Commons @ East Tennessee State University, 2018. https://dc.etsu.edu/etsu-works/2624.

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Contamination of methylmercury (MeHg) in aquatic products has been a wide spread health concern. The objective of this study is to determine total mercury (THg) and MeHg concentrations in different species of aquatic products from major offshore farms in China, and to assess health impacts from consumption. Results showed that the concentrations of THg and MeHg ranged 5.6–328.4 ng/g (wet weight) and 4.3–303.6 ng/g (wet weight) in aquatic products, respectively, and were very variable among species and origin sources. Target hazard quotient (THQ) suggested that MeHg exposure via consumption pos

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König, Stefanie [Verfasser], Oliver [Gutachter] Werz, Dirk [Gutachter] Hoffmeister, and Alexandra Kathrin [Gutachter] Kiemer. "Mode of action and target identification of anti-inflammatory natural products / Stefanie König ; Gutachter: Oliver Werz, Dirk Hoffmeister, Alexandra Kathrin Kiemer." Jena : Friedrich-Schiller-Universität Jena, 2020. http://nbn-resolving.de/urn:nbn:de:gbv:27-dbt-20200618-115401-005.

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König, Stefanie [Verfasser], Oliver Gutachter] Werz, Dirk [Gutachter] [Hoffmeister, and Alexandra Kathrin [Gutachter] Kiemer. "Mode of action and target identification of anti-inflammatory natural products / Stefanie König ; Gutachter: Oliver Werz, Dirk Hoffmeister, Alexandra Kathrin Kiemer." Jena : Friedrich-Schiller-Universität Jena, 2020. http://d-nb.info/1212509137/34.

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16

Mazraati, Tajabadi Fatemeh. "Identification of 3D Scaffolds Embedded in Natural Products and Synthesis of Focused Libraries." Thesis, Griffith University, 2017. http://hdl.handle.net/10072/365575.

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The ever-increasing demand for new drugs drives the need to explore new areas of biologically-relevant chemical space. Drug targets, largely the active sites of proteins, have three-dimensional shape. However, chiefly for reasons of synthetic tractability, the screening libraries that are extensively used for high throughput screening (HTS) drug discovery are mostly composed of flat aromatic and heteroaromatic compounds.1 This has resulted in a trend towards flatness in drug candidates, limiting the possibilities in the navigation of three-dimensional biological space. A variety of approaches,

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17

Williams, Karen Lindsay. "Personas in the Design Process: A tool for understanding others." Thesis, Available online, Georgia Institute of Technology, 2006, 2006. http://etd.gatech.edu/theses/available/etd-07102006-101208/.

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18

Deeb, Ahmad Atef Said [Verfasser], and Torsten Claus [Akademischer Betreuer] Schmidt. "Target and suspect screening of organic micropollutants and their transformation products in aqueous samples / Ahmad Atef Said Deeb ; Betreuer: Torsten Claus Schmidt." Duisburg, 2017. http://d-nb.info/113557281X/34.

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19

Zetterström, Caroline E. "Small Molecules as Tools in Biological Chemistry : Effects of Synthetic and Natural Products on the Type III Secretion System." Doctoral thesis, Umeå universitet, Kemiska institutionen, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-70281.

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The increasing use of antibiotics has led to a huge problem for society, as some bacteria have developed resistance towards many of the antibiotics currently available. To help find solutions to this problem we studied small molecules that inhibit bacterial virulence, the ability to cause disease. The type III secretion system (T3SS) is a conserved virulence system found in several gram-negative bacteria, including human and plants pathogens, such as Yersinia spp., Pseudomonas aeruginosa, Chlamydia spp., Salmonella spp., Shigella spp, enteropathogenic Escherichia coli (EPEC), enterohemorrhagic

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20

Jacobo-Herrera, Nadia Judith. "Anti-inflammatory properties and bioactive natural products from Witheringia solanacea, Withania frutescens (Solanaceae) and Valeriana officinalis (Valerianaceae) using NF-kappa as a molecular target." Thesis, University College London (University of London), 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.420313.

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21

Melo, Reymard Savio Sampaio de 1983. "Guidelines for target costing introduction in the real estate products development proces = Diretrizes para introdução do custeio-meta no processo de desenvolvimento de produtos imobiliários." [s.n.], 2015. http://repositorio.unicamp.br/jspui/handle/REPOSIP/258729.

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Orientador: Ariovaldo Denis Granja<br>Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Engenharia Civil, Arquitetura e Urbanismo<br>Made available in DSpace on 2018-08-27T16:54:00Z (GMT). No. of bitstreams: 1 Melo_ReymardSavioSampaiode_D.pdf: 3570435 bytes, checksum: 6810689a549becc35c07922f4a0849cb (MD5) Previous issue date: 2015<br>Resumo: Os problemas relacionados com a prática tradicional de redução de custos na construção civil e a necessidade de aumentar a competitividade de empresas do setor de real estate nortearam essa pesquisa. Neste sentido, o custeio-meta é uma

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22

Cockroft, Nicholas T. "Applications of Cheminformatics for the Analysis of Proteolysis Targeting Chimeras and the Development of Natural Product Computational Target Fishing Models." The Ohio State University, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=osu156596730476322.

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23

Lambert, Claire. "Young children's fast food brand knowledge, preference and equity." University of Western Australia. Faculty of Economics and Commerce, 2009. http://theses.library.uwa.edu.au/adt-WU2009.0116.

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Today's children are a multi-billion dollar consumer market that not only has the power to spend their own money but directly influences the spending for household consumer purchases. They present an extremely healthy and potentially long term wealthy consumer market for marketers to target and reap the benefits from their loyalty. However, the area of young children's consumer behaviour is significantly under researched. Very little is known about how young children develop preferences, make brand choices, and develop equity towards a brand. This study investigates the brand knowledge element

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24

Brown, Dustin Paul. "TARGET-DIRECTED BIOSYNTHETIC EVOLUTION: REDIRECTING PLANT EVOLUTION TO GENOMICALLY OPTIMIZE A PLANT’S PHARMACOLOGICAL PROFILE." UKnowledge, 2015. http://uknowledge.uky.edu/neurobio_etds/13.

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The dissertation describes a novel method for plant drug discovery based on mutation and selection of plant cells. Despite the industry focus on chemical synthesis, plants remain a source of potent and complex bioactive metabolites. Many of these have evolved as defensive compounds targeted on key proteins in the CNS of herbivorous insects, for example the insect dopamine transporter (DAT). Because of homology with the human DAT protein some of these metabolites have high abuse potential, but others may be valuable in treating drug dependence. This dissertation redirects the evolution of a nat

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25

Peterson, Denis Desmond. "An analysis of financial literacy in the target market of a state–owned bank / Peterson D.D." Thesis, North-West University, 2011. http://hdl.handle.net/10394/8167.

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The South African Postbank Limited has been tasked by Government with a social mandate to provide basic financial services to people receiving low income and people living in rural areas. Personal financial literacy is an essential element which affects financial inclusion in the target market of a state–owned bank. To achieve the bank?s social mandate and its objective, it would be vital to determine whether people in low income and rural demographics are financially literate. Financial literacy is defined as the ability to manage your money on a day–to–day basis, do future financial planning

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26

Osburg, Victoria-Sophie [Verfasser], Waldemar [Akademischer Betreuer] Toporowski, Lutz M. [Akademischer Betreuer] Kolbe, and Margarete [Akademischer Betreuer] Boos. "Products consisting of materials based on renewable resources: Drivers of purchase intention, consumers' information needs and target groups / Victoria-Sophie Osburg. Gutachter: Waldemar Toporowski ; Lutz M. Kolbe ; Margarete Boos. Betreuer: Waldemar Toporowski." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2015. http://d-nb.info/1071713507/34.

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27

Tavares, Ricardo Matos. "Plano de negócios para criação de loja online Kyuubit." Master's thesis, Instituto Superior de Economia e Gestão, 2018. http://hdl.handle.net/10400.5/16559.

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Mestrado em Ciências Empresariais<br>O presente trabalho tem como objetivo a criação de um plano de negócios para a loja online, a Kyuubit, que dedica à venda de produtos relacionados com a cultura pop. A implementação de um plano de negócios irá sem dúvida contribuir para a obtenção de investidores para este projeto. E, neste caso, os investidores potenciais irão querer analisar o plano de negócios, bem como todas as medidas para chegar ao sucesso do investimento. A internet é uma rede pública aberta com infinitas oportunidades comerciais. O ambiente excitante do comércio eletrónico inclui

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King, Larrie Leon Jr. "Private Labels and Personal Care: A Focus on Store Brand Package Design, Branding Design and Consumer Attitudes Towards Private Label Personal Care Products." Kent State University / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=kent1400330956.

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29

Heydenreuter, Wolfgang [Verfasser], Stephan A. [Akademischer Betreuer] [Gutachter] Sieber, and Tobias A. M. [Gutachter] Gulder. "Target identification of natural products by activity based protein profiling and a whole proteome inventory of background photocrosslinker binding / Wolfgang Heydenreuter ; Gutachter: Tobias A. M. Gulder, Stephan A. Sieber ; Betreuer: Stephan A. Sieber." München : Universitätsbibliothek der TU München, 2016. http://d-nb.info/1137624582/34.

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30

Walldén, Marcus. "Shooting Target - Design : Product Development." Thesis, Högskolan i Halmstad, Sektionen för ekonomi och teknik (SET), 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:hh:diva-25887.

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The project has involved the development of two kinds of shooting targets in partnership with Marcus Bergkvist and Christopher Åkerblom. The project from the client was divided into two parts. This thesis discusses solutions for hands-on transport, development of tripods and an overall design. The second thesis affect resetting systems for the products. The work was done with a process and methodology based on design perspectives. This process has involved the search of relevant data which has provided the platform and opportunity for appropriate and purposeful design work. Concept development

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Bergkvist, Marcus, and Christopher Åkerblom. "Shooting Target - Konstruktion : Product Development." Thesis, Högskolan i Halmstad, Maskinteknisk produktframtagning (MTEK), 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:hh:diva-25899.

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The shooting sport is one of the most widespread sports in the world and it is being practice in most countries. Based on their own experiences, in competition - and hobby shooting, the client M4Solutions found a demand and need for a shooting target that is manufactured in Sweden. The purpose of the project has been to develop, with the help of Marcus Walldén, two shooting targets from idea to finished product. These two shooting targets, Plate Rack Target and Dueling Tree, would each be equipped with a mechanical resetting system but will in the future have the ability to be provided with an

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32

Amara, Vamsee. "Target Costing for Product Redesigning." Master's thesis, Virginia Tech, 1998. http://hdl.handle.net/10919/37071.

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Increased competition and increased costs of designing made it important for the firms to identify the right products and the right methods for manufacturing the products. Firms should focus on customers and identify customer demands accurately to design the right products. Several management methods and techniques that are currently available improve one or more functions or processes in an industry and do not take the complete product life cycle into consideration. On the other hand target costing is a method / philosophy that takes financial, manufacturing and customer aspects into consi

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33

Бухкало, Светлана Ивановна, та Оксана Игоревна Ольховская. "Анализ возможностей комплексных технологий утилизации полимерной части твердых бытовых отходов". Thesis, Московский государственный университет дизайна и технологии, 2016. http://repository.kpi.kharkov.ua/handle/KhPI-Press/22983.

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Рассмотрены основные системы газификационных агрегатов большой единичной мощности. Выделены основные логистические факторы, влияющие на технологические схемы газификационных агрегатов такие, как природа, качество и состав газифицирующего сырья, номенклатура целевых продуктов, экологические требования по вредным выбросам и эмиссии парниковых газов, местоположение агрегата относительно крупных производственных комплексов, возможности конверсии отходов в полезные продукты.<br>The basic heat exchangers networks of big gasification plants with entrained-flow fuel gasification are considered. The ma

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Wallock-Richards, Daynea Juaneckah. "Natural products : biosynthesis, antimicrobial properties and protein targets." Thesis, University of Edinburgh, 2015. http://hdl.handle.net/1842/14188.

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The diversity of biosynthetic pathways in prokaryotes and eukaryotes has led to numerous bioactive natural products (NPs) which occupy a vast chemical space. Despite the current challenges in NP research, these molecules are still relevant today as they are a major source of human medicine as well as being useful biological tools. The elucidation of their biosynthetic pathways has also provided information about the biochemical and biophysical properties of fascinating enzyme families such as the α- oxoamine synthases (AOSs). The AOSs are an expanding group of pyridoxal 5’- phosphate (PLP)-dep

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Yang, Ben. "Discovery of Antimalarial Natural Products Against Malarial Targets Using Bioaffinity Mass Spectrometry." Thesis, Griffith University, 2016. http://hdl.handle.net/10072/367509.

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Natural products have proven to be effective in fighting various human diseases. The identification of bioactive natural products is an efficient method of finding new drug leads. Screening of natural product extracts on therapeutic targets for the presence of active compounds is a rapid and effective strategy to identify noncovalent interactions between active ligands from natural product extracts and their therapeutic protein targets. This thesis presents an effort of exploring a novel approach to screen natural product extracts using bioaffinity mass spectrometry against malarial targets an

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Gimeno-Fabra, Miquel. "Tailored continuous hydrothermal synthesis of targeted products." Thesis, University of Nottingham, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.716843.

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Continuous flow hydrothermal synthesis offers a cost-efficient, environmentally friendly and highly scalable route to produce a wide range of materials. Recent advances in reactor design at Nottingham have led to the development of a high-throughput, continuous flow synthesis (CFS) method that has already proven suitable for the controlled production of various inorganic micro- and nanomaterials, mainly metal oxide based particles. In this thesis, the scope of this technology has been widened to include materials never before produced using flow systems.

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Vieira, Henry Silva, and +55-92-98165-9404. "Recognition and Linking of Product Mentions in User-generated Contents." Universidade Federal do Amazonas, 2018. https://tede.ufam.edu.br/handle/tede/6686.

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Hjortman, Robin, and Kristian Harrysson. "Driveline : Moving infantry target (MIT)." Thesis, Tekniska Högskolan, Högskolan i Jönköping, JTH, Maskinteknik, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-30695.

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This report is part of a bachelor thesis implemented at Saab training systems AB in Huskvarna. It treats the concept development of the driveline on Moving infantry target, MIT. Today Saab has a problem in the shape of that their customers uses the wrong moment when tightening the cog belt of the driveline. As a consequence the cog belt has a high risk of snapping if it is too tight or pluck off if it is too loose. Thereto the electrical motors used in the MIT has gone out of production. The task boiled down to produce a number of proposals that improves the chucking or driveline solution toge

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Andersson, Jan. "Development of PET radioligands synthesized from in-target produced [¹¹C] methane." Stockholm, 2010. http://diss.kib.ki.se/2010/978-91-7409-797-9/.

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Clulow, James. "Unravelling the targets of electrophilic natural products in cancer with chemical proteomics." Thesis, Imperial College London, 2015. http://hdl.handle.net/10044/1/44878.

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Electrophilic natural products that are found in dietary sources such as curcumin, piperlongumine and sulforaphane have attracted considerable interest on account of their broad range of biological activities, leading to their assessment as therapeutics for a number of diseases. Despite extensive research, the mode of action and biological targets of these compounds remain poorly understood. These compounds are clearly not 'single target' molecules; dissecting their complex polypharmacology to determine the key targets and pathways presents a major challenge, and has limited progress in the cl

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Akhbari, Mohammad Reza, and Eric Wennberg. "Target Costing i Large Cap : -." Thesis, Linnéuniversitetet, Ekonomihögskolan, ELNU, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-20379.

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Master Thesis G3 in Business Administration, Business School at Linnaeus University, Management Control, 4FE90E, Spring 2012 Authors: Mohammad Akhbari och Eric Wennberg Tutor: Jan Alpenberg Title: Target Costing in Large Cap Background and problem formulation: Since the 1980s, the product of the company has become increasingly important, because of increased competition and rapid technological development. To succeed in the Product development, “Target Costing” can be used as an important financial tool to calculate costs based on an established price and profit margin. Research shows that the

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Kelley, Karen Corzine. "Gadolinium-148 and Other Spallation Production Cross Section Measurements for Accelerator Target Facilities." Diss., Georgia Institute of Technology, 2004. http://hdl.handle.net/1853/5143.

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At the Los Alamos Neutron Science Center accelerator complex, protons are accelerated to 800 MeV and directed to two tungsten targets, Target 4 at the Weapons Neutron Research facility and the 1L target at the Lujan Center. The Department of Energy requires hazard classification analyses to be performed on these targets and places limits on certain radionuclide inventories in the targets to avoid characterizing the facilities as nuclear facilities. Gadolinium-148 is a radionuclide created from the spallation of tungsten. Allowed isotopic inventories are particularly low for this isotope becaus

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Laguecir, Aziza. "Pour une approche sémiologique de la dynamique du target costing : une application à l'industrie française." Université Louis Pasteur (Strasbourg) (1971-2008), 2004. http://www.theses.fr/2004STR1EC04.

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Ce travail porte sur la dynamique d'un outil de gestion du processus de conception et de développement de nouveau produits : le Target Costing. En premier lieu, cette recherche vise à renouveler la conception théorique du Target Costing (et des outils de gestion en général), en adoptant une approche sémiologique de celui-ci et du processus dans lequel il s'insère. Cette approche nous a permis de développer un modèle instrumental de la dynamique du Target Costing. En second lieu, ce modèle est mis à l'épreuve par une application à l'industrie française. Cette application repose sur une méthodol

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Andino, Alexandra Elizabeth. "Price Risk Management Strategies for Virginia Dairy Producers." Master's thesis, Virginia Tech, 2004. http://hdl.handle.net/10919/37159.

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The 1996 and 2002 Farm Bill changes in milk support price legislation deregulated the market and milk prices are more volatile than ever. The use of a mechanism to reduce farmers' exposure to volatile milk prices has therefore become essential. This study evaluates the impact of two hedging strategies, one conservative and the other an intermediate one (more sophisticated). Optimal parameters for the two strategies are searched over a period of 5 years. Then, the performance, in terms of increased profitability and reduced variation, is assessed and the best performer is chosen and appl

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Jezequel, Gwenaëlle. "Synthèse et pharmacomodulation de composés antitumoraux naturels à motif hexahydroxanthène." Thesis, Université Paris-Saclay (ComUE), 2019. http://www.theses.fr/2019SACLS424.

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Les ORPphilins regroupent plusieurs familles de molécules naturelles, à forte activité cytotoxique qui présentent un mécanisme d'action original, en inhibant OSBP, une protéine responsable du transport intra-cellulaire du cholestérol. Cependant, elles sont toutes difficiles d’accès, que ce soit par extraction à partir des organismes dont elles sont issues ou par synthèse chimique.Les schweinfurthines (SWs), isolées de plantes du genre Macaranga, font partie de ces ORPphilins, et sont étudiées par notre équipe depuis plusieurs années. Lors de ces études, il a notamment été montré qu’un analogue

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Ellenberger, Urs. "X-ray diagnostics of laser-produced plasma in cylindrical and slab target geometry /." [S.l : s.n.], 1994. http://www.ub.unibe.ch/content/bibliotheken_sammlungen/sondersammlungen/dissen_bestellformular/index_ger.html.

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OLIVEIRA, INEZ C. de. "Recuperacao e purificacao do uranio utilizado em alvos para a producao de Mosup99." reponame:Repositório Institucional do IPEN, 1998. http://repositorio.ipen.br:8080/xmlui/handle/123456789/10688.

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Made available in DSpace on 2014-10-09T12:43:03Z (GMT). No. of bitstreams: 0<br>Made available in DSpace on 2014-10-09T14:05:37Z (GMT). No. of bitstreams: 1 06178.pdf: 4301800 bytes, checksum: 8ef60a5fb58c4649ffd7c1a0c70dc421 (MD5)<br>Dissertacao (Mestrado)<br>IPEN/D<br>Instituto de Pesquisas Energeticas e Nucleares - IPEN/CNEN-SP

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Alku, Jeton, and Judita Rashiti. "Target Costing i produktutvecklingsprocessen : En studie på Volvo Construction Equipment i Braås." Thesis, Linnéuniversitetet, Institutionen för ekonomistyrning och logistik (ELO), 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-40693.

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Bakgrund: Produktutvecklingsprocessen har på senare tid kommit att ses som en strategisk aktivitet som är avgörande för företagets överlevnad eftersom produktens utförande och kostnader till stor del fastställs innan tillverkning påbörjas. ”Target Costing” har sitt ursprung från Toyota i Japan och är en metod för strategisk kostnadsstyrning som har vuxit fram för att tidigt styra kostnader. Metoden används för att integrera kostnadsstyrning i produktutvecklingsprocessen i samstämmighet med kundkrav och företagets egna vinstkrav. Syfte: Syftet med studien är att beskriva och analysera hur ”Targ

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Devenish, Sean. "Studies of natural product derivatives: targeted polymer drug conjugates." Thesis, University of Canterbury. Chemistry, 2004. http://hdl.handle.net/10092/6661.

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Polymer drug conjugates are an emerging class of therapeutic agent that offer advantages in the treatment of cancer through long circulation times and passive targeting. A further benefit of using a polymeric framework is that it readily allows attachment of targeting motifs to enhance the drug specificity, as well as allowing variation of the drug component. In this work a series of targeted polymer drug conjugates were prepared that incorporated different drugs via peptide linkers designed to be stable in circulation but degradable at the target site. In order to ensure stability in circula

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Fung, Ying-Kit (Richard). "An intelligent hybrid model for customer requirements interpretation and product design targets determination." Thesis, Loughborough University, 1997. https://dspace.lboro.ac.uk/2134/7419.

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The transition of emphasis in business competition from a technology-led age to a market-oriented era has led to a rapid shift from the conventional "economy of scale" towards the "economy of scope" in contemporary manufacturing. Hence, it is necessary and essential to be able to respond to the dynamic market and customer requirements systematically and consistently. The central theme of this research is to rationalise and improve the conventional means of analysing and interpreting the linguistic and often imprecise customer requirements in order to identify the essential product features and

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