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Journal articles on the topic '"targeted activity"'

Author: Grafiati

Published: 5 June 2025

Last updated: 15 July 2025

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1

Bulligan, Guido, Massimiliano Marcellino, and Fabrizio Venditti. "Forecasting economic activity with targeted predictors." International Journal of Forecasting 31, no. 1 (2015): 188–206. http://dx.doi.org/10.1016/j.ijforecast.2014.03.004.

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2

Chistyakov, V. A., M. A. Sazykina, A. A. Alexandrova, et al. "Antimutagenic activity of mitochondria-targeted plastoquinone derivative." Biochemistry (Moscow) 75, no. 3 (2010): 269–73. http://dx.doi.org/10.1134/s0006297910030028.

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3

Kingwell, Katie. "Nasal markers of CNS-targeted drug activity." Nature Reviews Neurology 7, no. 11 (2011): 596. http://dx.doi.org/10.1038/nrneurol.2011.166.

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4

Engineer, Navzer D., Jonathan R. Riley, Jonathan D. Seale, et al. "Reversing pathological neural activity using targeted plasticity." Nature 470, no. 7332 (2011): 101–4. http://dx.doi.org/10.1038/nature09656.

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5

Morgan, Philip J., Myles D. Young, Jordan J. Smith, and David R. Lubans. "Targeted Health Behavior Interventions Promoting Physical Activity." Exercise and Sport Sciences Reviews 44, no. 2 (2016): 71–80. http://dx.doi.org/10.1249/jes.0000000000000075.

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6

Wajih, Nadeem, Anuj Jailwala, Mark Gladwin, David L. Caudell, and Daniel B. Kim-Shapiro. "Superior Targeted Anti-Platelet Activity of Nitrite." Free Radical Biology and Medicine 100 (November 2016): S154. http://dx.doi.org/10.1016/j.freeradbiomed.2016.10.405.

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7

Mikell, Charles, Michael B. Sisti, and Guy M. McKhann. "Reversing Pathological Neural Activity Using Targeted Plasticity." Neurosurgery 68, no. 4 (2011): N18—N19. http://dx.doi.org/10.1227/01.neu.0000395792.97271.ae.

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TAKAHASHI, Chisato, Tatsuya YAZAKI, Naoyuki SUGIYAMA, and Yasushi ISHIHAMA. "Selected Reaction Monitoring of Kinase Activity-Targeted Phosphopeptides." CHROMATOGRAPHY 40, no. 2 (2019): 39–47. http://dx.doi.org/10.15583/jpchrom.2019.005.

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9

Prafulla, Sabale, Potey Lata, Rahangdale Priya, and Sabale Vidya. "Novel Curcumin Derivatives: Targeted for Anti-Inflammatory Activity." Asian Journal of Research in Chemistry 12, no. 2 (2019): 49. http://dx.doi.org/10.5958/0974-4150.2019.00011.7.

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10

Cao, Longbing, Yanchang Zhao, and Chengqi Zhang. "Mining Impact-Targeted Activity Patterns in Imbalanced Data." IEEE Transactions on Knowledge and Data Engineering 20, no. 8 (2008): 1053–66. http://dx.doi.org/10.1109/tkde.2007.190635.

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Guy, Collette S., Kathryn Murray, Matthew I. Gibson, and Elizabeth Fullam. "Dimeric benzoboroxoles for targeted activity against Mycobacterium tuberculosis." Organic & Biomolecular Chemistry 17, no. 43 (2019): 9524–28. http://dx.doi.org/10.1039/c9ob02222h.

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12

Ellerby, H. Michael, Wadih Arap, Lisa M. Ellerby, et al. "Anti-cancer activity of targeted pro-apoptotic peptides." Nature Medicine 5, no. 9 (1999): 1032–38. http://dx.doi.org/10.1038/12469.

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13

Hoogendoorn, Sascha, Kim L. Habets, Solène Passemard, et al. "Targeted pH-dependent fluorescent activity-based cathepsin probes." Chemical Communications 47, no. 33 (2011): 9363. http://dx.doi.org/10.1039/c1cc12947c.

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14

Ellis, Lee M., and Daniel J. Hicklin. "VEGF-targeted therapy: mechanisms of anti-tumour activity." Nature Reviews Cancer 8, no. 8 (2008): 579–91. http://dx.doi.org/10.1038/nrc2403.

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15

Wu, Chenliang, Jon Vincelette, Baby Martin-McNulty, et al. "Amplified anticoagulant activity of tissue factor-targeted thrombomodulin." Thrombosis and Haemostasis 96, no. 09 (2006): 317–24. http://dx.doi.org/10.1160/th06-04-0219.

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SummaryTissue factor (TF) exposure isa potent pro-thrombotic trigger that initiates activation of the coagulation cascade, while thrombomodulin (TM) is a potent anticoagulant protein that limits the extent of activation. Both TF neutralizing antibodies and soluble TM (sTM) are effective anticoagulants. We have developed a novel anticoagulant fusion protein, Ab(TF)-TM, by fusing a TF-neutralizing single-chain antibody, Ab(TF), to an active fragment of TM. Ab(TF)-TM is a novel anticoagulant targeting to sites of TF exposure with a dual mechanism of action. The Ab(TF) portion of the molecule inhi

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16

Rice, Douglas R., María de Lourdes Betancourt Mendiola, Claribel Murillo-Solano, et al. "Antiplasmodial activity of targeted zinc(II)-dipicolylamine complexes." Bioorganic & Medicinal Chemistry 25, no. 10 (2017): 2754–60. http://dx.doi.org/10.1016/j.bmc.2017.03.050.

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17

Hodder, Joanne N., and Peter J. Keir. "Targeted gripping reduces shoulder muscle activity and variability." Journal of Electromyography and Kinesiology 22, no. 2 (2012): 186–90. http://dx.doi.org/10.1016/j.jelekin.2011.11.011.

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18

Tuszynski, Meg Patrick, and Dean Stansel. "Targeted state economic development incentives and entrepreneurship." Journal of Entrepreneurship and Public Policy 7, no. 3 (2018): 235–47. http://dx.doi.org/10.1108/jepp-d-18-00033.

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Purpose The purpose of this paper is to examine the relationship between state economic development incentives programs and entrepreneurial activity. Design/methodology/approach The authors use panel data and a fixed-effects model to examine the determinants of five measures of entrepreneurial activity. To measure state economic development incentives programs, they use a new and substantially improved data set from Bartik (2017). They also include a measure for economic freedom, the Fraser Institute’s Economic Freedom of North America index. Findings The authors find a robustly negative relat

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19

Khusainova, E., D. Davletshin, R. Khadiullina, et al. "77P Targeted compounds for modulation of mutant p53 activity." Annals of Oncology 33 (October 2022): S1407. http://dx.doi.org/10.1016/j.annonc.2022.09.078.

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20

Boyko, Natalia. "Content-Targeted Structuring of Social Activity on the Internet." Logos et Praxis, no. 4 (February 2019): 67–73. http://dx.doi.org/10.15688/lp.jvolsu.2018.4.8.

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The article presents the results of a monitoring study of social activity on the Internet. Monitoring of the development and use of the Internet in modern society shows an active growth in the number of users of the World Wide Web. The total number of Internet users is growing dynamically together with the intensity of network use. The high intensity of Internet use, as well as the predominantly "home" use of the network, allows us to increase overall online activity, to improve the quality and versatility of such activity. There are significant qualitative changes in the use of the Internet.

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21

Haggerty, Chuck, Helene Kretzmer, Christina Riemenschneider, et al. "Dnmt1 has de novo activity targeted to transposable elements." Nature Structural & Molecular Biology 28, no. 7 (2021): 594–603. http://dx.doi.org/10.1038/s41594-021-00603-8.

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AbstractDNA methylation plays a critical role during development, particularly in repressing retrotransposons. The mammalian methylation landscape is dependent on the combined activities of the canonical maintenance enzyme Dnmt1 and the de novo Dnmts, 3a and 3b. Here, we demonstrate that Dnmt1 displays de novo methylation activity in vitro and in vivo with specific retrotransposon targeting. We used whole-genome bisulfite and long-read Nanopore sequencing in genetically engineered methylation-depleted mouse embryonic stem cells to provide an in-depth assessment and quantification of this activ

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22

Maggi, Maristella, Greta Pessino, Isabella Guardamagna, Leonardo Lonati, Cristina Pulimeno, and Claudia Scotti. "A Targeted Catalytic Nanobody (T-CAN) with Asparaginolytic Activity." Cancers 13, no. 22 (2021): 5637. http://dx.doi.org/10.3390/cancers13225637.

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E. coli L-asparaginase is an amidohydrolase (EC 3.5.1.1) which has been successfully used for the treatment of Acute Lymphoblastic Leukemia for over 50 years. Despite its efficacy, its side effects, and especially its intrinsic immunogenicity, hamper its usage in a significant subset of cases, thus limiting therapeutic options. Innovative solutions to improve on these drawbacks have been attempted, but none of them have been truly successful so far. In this work, we fully replaced the enzyme scaffold, generating an active, miniaturized form of L-asparaginase by protein engineering of a camel s

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23

Manca, Claudia, Mi-Sun Koo, Blas Peixoto, Dorothy Fallows, Gilla Kaplan, and Selvakumar Subbian. "Host Targeted Activity of Pyrazinamide in Mycobacterium tuberculosis Infection." PLoS ONE 8, no. 8 (2013): e74082. http://dx.doi.org/10.1371/journal.pone.0074082.

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24

Boyden, Edward S., Feng Zhang, Ernst Bamberg, Georg Nagel, and Karl Deisseroth. "Millisecond-timescale, genetically targeted optical control of neural activity." Nature Neuroscience 8, no. 9 (2005): 1263–68. http://dx.doi.org/10.1038/nn1525.

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25

Muntian, Liliia. "STATE POLICY AS A FORM OF TARGETED STATE ACTIVITY." Public Administration and Regional Development 25 (October 25, 2024): 989–1008. http://dx.doi.org/10.34132/pard2024.25.13.

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The article examines state policy as an organized and purposeful activity of the state, which provides for the protection of public interests, ensures the adoption of balanced and justified state decisions, and contributes to the stable development of Ukrainian society. Issues of state policy formation in the system of planning and implementation of development plans of modern society are considered. It was determined that with the transition from bureaucratic forms to innovative methods of managing the state and society, state policy acquires certain signs of publicity, due to the involvement

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26

Shilovsky, G. A., E. V. Sorokina, and D. N. Akhaev. "Anti-Aging Medicine: Mitochondria-Targeted Antioxidants and Physical Activity." Biology Bulletin Reviews 14, no. 4 (2024): 426–33. http://dx.doi.org/10.1134/s2079086424600188.

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27

Wang, Meiyao, Yang Shen, Illarion V. Turko, Daniel C. Nelson, and Shuwei Li. "Determining Carbapenemase Activity with18O Labeling and Targeted Mass Spectrometry." Analytical Chemistry 85, no. 22 (2013): 11014–19. http://dx.doi.org/10.1021/ac402627k.

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28

Popov, Tzvetan G., Almut Carolus, David Schubring, Petia Popova, Gregory A. Miller, and Brigitte S. Rockstroh. "Targeted training modifies oscillatory brain activity in schizophrenia patients." NeuroImage: Clinical 7 (2015): 807–14. http://dx.doi.org/10.1016/j.nicl.2015.03.010.

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29

Rojo, F., A. Dalmases, J. M. Corominas, and J. Albanell. "Pharmacodynamics: biological activity of targeted therapies in clinical trials." Clinical and Translational Oncology 9, no. 10 (2007): 634–44. http://dx.doi.org/10.1007/s12094-007-0116-2.

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30

Salerno, Manuela, Sofia Avnet, Caterina Fotia, et al. "Antineoplastic activity of bone-targeted nanoparticles loaded with doxorubicin." Bone 42 (March 2008): S106. http://dx.doi.org/10.1016/j.bone.2007.12.205.

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31

Bourouis, Marc. "Targeted increase in shaggy activity levels blocks wingless signaling." genesis 34, no. 1-2 (2002): 99–102. http://dx.doi.org/10.1002/gene.10114.

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32

Nakanishi, Takeo, Ikumi Tamai, Akiyoshi Takaki, and Akira Tsuji. "Cancer cell-targeted drug delivery utilizing oligopeptide transport activity." International Journal of Cancer 88, no. 2 (2000): 274–80. http://dx.doi.org/10.1002/1097-0215(20001015)88:2<274::aid-ijc20>3.0.co;2-5.

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33

He, Jian, Maxwell H. Anderson, Wenyuan Shi, and Randal Eckert. "Design and activity of a ‘dual-targeted’ antimicrobial peptide." International Journal of Antimicrobial Agents 33, no. 6 (2009): 532–37. http://dx.doi.org/10.1016/j.ijantimicag.2008.11.013.

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34

Oleksandr, Kushchenko. "Effect of ergotherapy on the level of self-care of children with cerebral palsy." Slobozhanskyi Herald of Science and Sport, no. 3(65) (June 30, 2018): 26–31. https://doi.org/10.5281/zenodo.1321800.

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<strong><em>Purpose: </em></strong><em>form a block of ergotherapy for children with cerebral palsy, supplement it with a program of physical rehabilitation and determine its utility in increasing the level of self-service. </em> <strong><em>Material & Methods:</em></strong><em> analysis and generalization of foreign and domestic special scientific and methodological literature; pediatric assessment of activity limitations (PEDI). The contingent of subjects – 106 children 4–6 years old, 54 of them with spastic hemiplegia and 52 with spastic diplegia. Methods of physical th

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35

Pise, Shilpa A., and Ajay G. Pise. "Enzymosomes: Novel Targeted Enzyme Delivery System." International Journal of Medical & Pharmaceutical Sciences 09, no. 01 (2019): 01–11. http://dx.doi.org/10.31782/ijmps.2019.9101.

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The purpose of the study is to develop enzymosomes as a novel site-specific medicine delivery technique. Enzymosomes take use of an enzyme’s unique properties, which include the ability to bind to a specific substrate at a controlled rate and catalyse the product synthesis process. When an enzyme is covalently bonded to the surface of liposomes/lipid vesicles, enzymosomes are generated. Enzymes are connected via acylation, direct conjugation, physical adsorption, and encapsulation strategies to create enzymosomes with customized activity. Such innovative drug delivery systems exhibit effective

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36

Tsaneva, I. R., and S. C. West. "Targeted versus non-targeted DNA helicase activity of the RuvA and RuvB proteins of Escherichia coli." Journal of Biological Chemistry 269, no. 42 (1994): 26552–58. http://dx.doi.org/10.1016/s0021-9258(18)47230-4.

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37

Garrido, M. A., P. Perez, J. A. Titus, et al. "Targeted cytotoxic cells in human peripheral blood lymphocytes." Journal of Immunology 144, no. 8 (1990): 2891–98. http://dx.doi.org/10.4049/jimmunol.144.8.2891.

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Abstract We have isolated subsets of cells from human PBL and have investigated their abilities to mediate lysis targeted by bispecific antibodies. Targeted cytotoxic cells were divided into two distinct types based on buoyant density. The low buoyant density fraction contained all of the targetable cytotoxic activity in unstimulated PBL, including both T and K cells targeted with anti-CD3 and anti-Fc gamma RIII (CD16) containing bispecific antibodies, respectively. Both types of targetable cytotoxic cells required IL-2 for maintenance of cytotoxic activity, expressed the CD56 (NKH1) marker, a

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38

Mizukoshi, Eishiro, and Shuichi Kaneko. "Telomerase-Targeted Cancer Immunotherapy." International Journal of Molecular Sciences 20, no. 8 (2019): 1823. http://dx.doi.org/10.3390/ijms20081823.

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Telomerase, an enzyme responsible for the synthesis of telomeres, is activated in many cancer cells and is involved in the maintenance of telomeres. The activity of telomerase allows cancer cells to replicate and proliferate in an uncontrolled manner, to infiltrate tissue, and to metastasize to distant organs. Studies to date have examined the mechanisms involved in the survival of cancer cells as targets for cancer therapeutics. These efforts led to the development of telomerase inhibitors as anticancer drugs, drugs targeting telomere DNA, viral vectors carrying a promoter for human telomeras

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39

HAGEN, Thilo, Jaswinder K. SETHI, Neale FOXWELL, and Antonio VIDAL-PUIG. "Signalling activity of beta-catenin targeted to different subcellular compartments." Biochemical Journal 379, no. 2 (2004): 471–77. http://dx.doi.org/10.1042/bj20031749.

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β-Catenin plays a dual role as an adhesion molecule in adherens junctions at the plasma membrane and as a key intermediate in the canonical Wnt signalling pathway. The cytosolic soluble pool of β-catenin, involved in the transmission of the Wnt signal, is normally subjected to rapid protein degradation. On activation of the Wnt cascade, β-catenin becomes stabilized and then translocates into the nucleus where it co-activates transcription factors of the TCF (T-cell factor)/LEF (lymphoid enhancer factor) family. The expression of plasma membrane-targeted forms of β-catenin has been shown to als

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40

Hagerty, Brendan L., Guillaume J. Pegna, Jian Xu, Chin-Hsien Tai, and Christine Alewine. "Mesothelin-Targeted Recombinant Immunotoxins for Solid Tumors." Biomolecules 10, no. 7 (2020): 973. http://dx.doi.org/10.3390/biom10070973.

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Mesothelin (MSLN) is a cell surface glycoprotein normally expressed only on serosal surfaces, and not found in the parenchyma of vital organs. Many solid tumors also express MSLN, including mesothelioma and pancreatic adenocarcinoma. Due to this favorable expression profile, MSLN represents a viable target for directed anti-neoplastic therapies, such as recombinant immunotoxins (iToxs). Pre-clinical testing of MSLN-targeted iTox’s has yielded a strong body of evidence for activity against a number of solid tumors. This has led to multiple clinical trials, testing the safety and efficacy of the

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41

Motzer, Robert J., and Ronald M. Bukowski. "Targeted Therapy for Metastatic Renal Cell Carcinoma." Journal of Clinical Oncology 24, no. 35 (2006): 5601–8. http://dx.doi.org/10.1200/jco.2006.08.5415.

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The discovery of a relationship for the VHL tumor suppressor gene, hypoxia inducible factor-1 alpha, and vascular endothelial growth factor in the growth of clear-cell renal cell carcinoma (RCC) has identified a pathway for novel targeted therapy. This study evaluated the impact of these agents on metastatic RCC (mRCC), and highlights recent phase II and III trials. A systematic review examined the clinical data for novel targeted agents in mRCC, with a focus on randomized phase II and III trials of the novel targeted agents sunitinib, temsirolimus, sorafenib, and bevacizumab. Several agents,

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42

Xia, Chunlei, Ying Wang, Chen Liu, et al. "Novel Peptide CM 7 Targeted c-Met with Antitumor Activity." Molecules 25, no. 3 (2020): 451. http://dx.doi.org/10.3390/molecules25030451.

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Anomalous changes of the cell mesenchymal–epithelial transition factor (c-Met) receptor tyrosine kinase signaling pathway play an important role in the occurrence and development of human cancers, including gastric cancer. In this study, we designed and synthesized a novel peptide (CM 7) targeting the tyrosine kinase receptor c-Met, that can inhibit c-Met-mediated signaling in MKN-45 and U87 cells. Its affinity to human c-Met protein or c-Met-positive cells was determined, which showed specific binding to c-Met with high affinity. Its biological activities against MKN-45 c-Met-positive cells w

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43

Zhang, Fan, Jinxia Jiang, and Xiaogu He. "Preparation of Targeted Nanoparticles and Activity of Anti-Helicobacter Pylori." Science of Advanced Materials 13, no. 8 (2021): 1458–66. http://dx.doi.org/10.1166/sam.2021.4025.

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Helicobacter pylori (Hp) is a gram-negative spiral bacterium that grows in a microaerobic environment and can be found in people with gastritis and ulcer diseases. First, the drug 5-aminosalicylic acid (5-ASA) for the treatment of ulcerative colitis (UC) was investigated in this study. In order to increase the drug concentration in the diseased colon, silica nanoparticles (SNP) were prepared by the microemulsion method. Then, the drug 5-ASA was grafted onto the surface of the modified SNP, so as to obtain the targeted nanoparticles 5-ASA-SNP. The synthesis and drug loading of the materials wer

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44

Busov, Vladimir. "PROGRAM-TARGETED MANAGEMENT OF INNOVATIVE-INVESTMENT ACTIVITY OF LARGE COMPANIES." VESTNIK UNIVERSITETA, no. 6 (2018): 43–47. http://dx.doi.org/10.26425/1816-4277-2018-6-43-47.

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45

Zhang, Yurui, Junying Wang, Yuanyuan Li, Feng Wang, Fujun Yang, and Wenqing Xu. "Synthesis and Radioprotective Activity of Mitochondria Targeted Dihydropyridines In Vitro." International Journal of Molecular Sciences 18, no. 11 (2017): 2233. http://dx.doi.org/10.3390/ijms18112233.

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46

Prochazka, Arthur. "Targeted stimulation of the spinal cord to restore locomotor activity." Nature Medicine 22, no. 2 (2016): 125–26. http://dx.doi.org/10.1038/nm.4043.

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47

Fahlman, Mariane, Heather L. Hall, and Lila Gutuskey. "Minority Youth, Physical Activity, and Fitness Levels: Targeted Interventions Needed." American Journal of Health Education 46, no. 6 (2015): 338–46. http://dx.doi.org/10.1080/19325037.2015.1077758.

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48

Pereira, David M., Alexandra Noites, Patricia Valentão, et al. "Targeted Metabolite Analysis and Biological Activity ofPieris brassicaeFed withBrassica rapavar.rapa." Journal of Agricultural and Food Chemistry 57, no. 2 (2009): 483–89. http://dx.doi.org/10.1021/jf8031638.

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49

Hendrik Schmidt, Jan, Mathias Perslev, Lina Bukowski, et al. "Constitutive internalization across therapeutically targeted GPCRs correlates with constitutive activity." Basic & Clinical Pharmacology & Toxicology 126, S6 (2019): 116–21. http://dx.doi.org/10.1111/bcpt.13274.

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50

Alavinia, Sedigheh, and Ramin Ghorbani-Vaghei. "Targeted development of hydrophilic porous polysulfonamide gels with catalytic activity." Journal of Physics and Chemistry of Solids 146 (November 2020): 109573. http://dx.doi.org/10.1016/j.jpcs.2020.109573.

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