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Journal articles on the topic 'Targeted Delivery Vehicles'

Author: Grafiati

Published: 5 June 2025

Last updated: 2 August 2025

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1

Laakkonen, Pirjo, and Kirsi Vuorinen. "Homing peptides as targeted delivery vehicles." Integrative Biology 2, no. 7-8 (2010): 326–37. http://dx.doi.org/10.1039/c0ib00013b.

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2

Backer, Marina V., Renee Aloise, Kristen Przekop, Konstantin Stoletov, and Joseph M. Backer. "Molecular Vehicles for Targeted Drug Delivery." Bioconjugate Chemistry 13, no. 3 (2002): 462–67. http://dx.doi.org/10.1021/bc0155770.

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3

Haq M, Misbah Ul. "Revolutionizing Drug Delivery: Targeted Approaches and Innovations for Effective Treatment." Pharmaceutical Drug Regulatory Affairs Journal 6, no. 1 (2023): 1–8. http://dx.doi.org/10.23880/pdraj-16000138.

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Targeted drug delivery, also referred to as intelligent drug delivery, is a therapeutic approach that aims to enhance drug concentration in specific regions of the body relative to others. There are two strategies employed to target drugs to specific organs or tissues: passive targeting and active targeting. Drug delivery vehicles are utilized to transport the medication to the desired location. An ideal drug delivery vehicle should have the ability to overcome barriers such as the blood-brain barrier. Conventional drug delivery systems distribute drugs throughout the body via the bloodstream,

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Wen, Yuting, Hongzhen Bai, Jingling Zhu, Xia Song, Guping Tang, and Jun Li. "A supramolecular platform for controlling and optimizing molecular architectures of siRNA targeted delivery vehicles." Science Advances 6, no. 31 (2020): eabc2148. http://dx.doi.org/10.1126/sciadv.abc2148.

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It requires multistep synthesis and conjugation processes to incorporate multifunctionalities into a polyplex gene vehicle to overcome numerous hurdles during gene delivery. Here, we describe a supramolecular platform to precisely control, screen, and optimize molecular architectures of siRNA targeted delivery vehicles, which is based on rationally designed host-guest complexation between a β-cyclodextrin–based cationic host polymer and a library of guest polymers with various PEG shape and size, and various density of ligands. The host polymer is responsible to load/unload siRNA, while the gu

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Suresh, Dhananjay, Brian Jenkins, Ajit Zambre, Anandhi Upendran, and Raghuraman Kannan. "Systematic Evaluation of Protein-Based Nanoparticles for Stable Delivery of Small Interfering RNA." Journal of Biomedical Nanotechnology 16, no. 7 (2020): 1169–81. http://dx.doi.org/10.1166/jbn.2020.2953.

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Developing a delivery vehicle to protect siRNA from degradation is a significant challenge. To solve this challenge, researchers attempted to use protein-based nanoparticles to deliver siRNA with limited to moderate success. However, a systematic investigation of comparing the ability of different protein-based nanoparticles as vehicles to deliver siRNA stably within cells is still unavailable. Therefore, in this study we synthesized a library of both non-targeted (proteinsiRNA) nanoparticles (NPs) and targeted (antibody conjugated protein-siRNA) NPs and evaluated ability to stably deliver siR

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Venkataraman, Srividhya, Mehdi Shahgolzari, Afagh Yavari, and Kathleen Hefferon. "Bacteriophages as Targeted Therapeutic Vehicles: Challenges and Opportunities." Bioengineering 12, no. 5 (2025): 469. https://doi.org/10.3390/bioengineering12050469.

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Bacteriophages, with their distinctive ability to selectively target host bacteria, stand out as a compelling tool in the realm of drug and gene delivery. Their assembly from proteins and nucleic acids, coupled with their modifiable and biologically unique properties, enables them to serve as efficient and safe delivery systems. Unlike conventional nanocarriers, which face limitations such as non-specific targeting, cytotoxicity, and reduced transfection efficiency in vivo, engineered phages exhibit promising potential to overcome these hurdles and improve delivery outcomes. This review highli

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Koev, Todor T., Hannah C. Harris, Sara Kiamehr, Yaroslav Z. Khimyak, and Frederick J. Warren. "Starch hydrogels as targeted colonic drug delivery vehicles." Carbohydrate Polymers 289 (August 2022): 119413. http://dx.doi.org/10.1016/j.carbpol.2022.119413.

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Ali, Yousaf, Ali Alqudah, Sadiq Ahmad, Shafida Abd Hamid, and Umar Farooq. "Macromolecules as targeted drugs delivery vehicles: an overview." Designed Monomers and Polymers 22, no. 1 (2019): 91–97. http://dx.doi.org/10.1080/15685551.2019.1591681.

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9

Wu, Guicun, Fang Zhou, Linfu Ge, Ximin Liu, and Fansheng Kong. "Novel Mannan-PEG-PE Modified Bioadhesive PLGA Nanoparticles for Targeted Gene Delivery." Journal of Nanomaterials 2012 (2012): 1–9. http://dx.doi.org/10.1155/2012/981670.

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Purpose. Biodegradable polymeric nanoparticles have been used frequently as gene delivery vehicles. The aim of this study is to modify bioadhesive PLGA nanoparticles with novel synthetic mannan-PEG-PE (MN-PEG-PE) to obtain active targeted gene delivery system.Methods. Mannan-PEG-PE ligands were synthesized and modified onto the NPs/pEGFP complexes. The modification rate was optimized, and the characteristics of the vehicle were evaluated. Then, the modified vectors were intravenous delivered to rats, andin vivotargeting behavior of MN-PEG-PE modified PLGA nanoparticles/pEGFP complexes (MN-PEG-

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Zhogla, V., E. Bletsko, S. Gayibova, V. Shmanai, and S. Shcharbina. "Targeted drug delivery based on multifunctional dendrimer nanosystems." Science and Innovations 1, no. 5 (2025): 78–83. https://doi.org/10.29235/1818-9857-2025-5-78-83.

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Targeted delivery of drugs based on dendrimers has a number of advantages for the treatment of cancer. The drug is delivered to specific tissues and organs, thereby minimizing the undesirable effect on healthy cells. Nanoparticles not only reduce the toxicity of anticancer drugs, but also increase their bioavailability and stability in the body. Dendrimers are considered the most promising as drug delivery vehicles due to their non-immunogenicity and controlled synthesis. They have shown their effectiveness in many areas of biology and medicine, namely chemotherapy, vaccine development, and de

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11

Dong, Xiaolu. "Microorganisms as Vehicles for Targeted Drug Delivery: Applications and Prospects." Theoretical and Natural Science 114, no. 1 (2025): 72–82. https://doi.org/10.54254/2753-8818/2025.pj25375.

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Microbial-targeted drug delivery systems represent an emerging and rapidly developing therapeutic strategy, garnering widespread attention for their potential. By utilizing engineered microorganismssuch as probiotics, Escherichia coli, and bacteriophagesas drug carriers, these systems enable precise, targeted drug delivery and controlled release, particularly in the treatment of tumors, autoimmune diseases, and inflammatory conditions. Microorganisms offer distinct advantages by navigating complex physiological and pathological environments through their inherent chemotaxis, metabolic adaptabi

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He, Lili, Zhenghui Shang, Hongmei Liu, and Zhi-xiang Yuan. "Alginate-Based Platforms for Cancer-Targeted Drug Delivery." BioMed Research International 2020 (October 7, 2020): 1–17. http://dx.doi.org/10.1155/2020/1487259.

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As an acidic, ocean colloid polysaccharide, alginate is both a biopolymer and a polyelectrolyte that is considered to be biocompatible, nontoxic, nonimmunogenic, and biodegradable. A significant number of studies have confirmed the potential use of alginate-based platforms as effective vehicles for drug delivery for cancer-targeted treatment. In this review, the focus is on the formation of alginate-based cancer-targeted delivery systems. Specifically, some general chemical and physical properties of alginate and different types of alginate-based delivery systems are discussed, and various kin

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Narayanaswamy, Radhika, and Vladimir P. Torchilin. "Hydrogels and Their Applications in Targeted Drug Delivery." Molecules 24, no. 3 (2019): 603. http://dx.doi.org/10.3390/molecules24030603.

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Conventional drug delivery approaches are plagued by issues pertaining to systemic toxicity and repeated dosing. Hydrogels offer convenient drug delivery vehicles to ensure these disadvantages are minimized and the therapeutic benefits from the drug are optimized. With exquisitely tunable physical properties that confer them great controlled drug release features and the merits they offer for labile drug protection from degradation, hydrogels emerge as very efficient drug delivery systems. The versatility and diversity of the hydrogels extend their applications beyond targeted drug delivery al

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Kou, Longfa, Qing Yao, Hailin Zhang, et al. "Transporter-Targeted Nano-Sized Vehicles for Enhanced and Site-Specific Drug Delivery." Cancers 12, no. 10 (2020): 2837. http://dx.doi.org/10.3390/cancers12102837.

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Nano-devices are recognized as increasingly attractive to deliver therapeutics to target cells. The specificity of this approach can be improved by modifying the surface of the delivery vehicles such that they are recognized by the target cells. In the past, cell-surface receptors were exploited for this purpose, but plasma membrane transporters also hold similar potential. Selective transporters are often highly expressed in biological barriers (e.g., intestinal barrier, blood–brain barrier, and blood–retinal barrier) in a site-specific manner, and play a key role in the vectorial transfer of

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Liu, Dali, and Xiangkai Li. "Exosomes as Targeted Drug Delivery Vehicles: Perspectives and Challenges." Current Drug Metabolism 20, no. 10 (2019): 772. http://dx.doi.org/10.2174/138920022010191205141812.

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Liu, Dali, and Xiangkai Li. "Exosomes as Targeted Drug Delivery Vehicles: Perspectives and Challenges." Current Drug Metabolism 21, no. 5 (2020): 329. http://dx.doi.org/10.2174/138920022105200701160418.

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Liu, Daxing, and Debra T. Auguste. "Cancer targeted therapeutics: From molecules to drug delivery vehicles." Journal of Controlled Release 219 (December 2015): 632–43. http://dx.doi.org/10.1016/j.jconrel.2015.08.041.

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18

Giles, Breanna, Maryam Nakhjavani, Andrew Wiesa, Tareeque Knight, Sarah Shigdar, and Rasika M. Samarasinghe. "Unravelling the Glioblastoma Tumour Microenvironment: Can Aptamer Targeted Delivery Become Successful in Treating Brain Cancers?" Cancers 15, no. 17 (2023): 4376. http://dx.doi.org/10.3390/cancers15174376.

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The key challenges to treating glioblastoma multiforme (GBM) are the heterogeneous and complex nature of the GBM tumour microenvironment (TME) and difficulty of drug delivery across the blood–brain barrier (BBB). The TME is composed of various neuronal and immune cells, as well as non-cellular components, including metabolic products, cellular interactions, and chemical compositions, all of which play a critical role in GBM development and therapeutic resistance. In this review, we aim to unravel the complexity of the GBM TME, evaluate current therapeutics targeting this microenvironment, and

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19

Dunuweera, Shashiprabha Punyakantha, Rajapakse Mudiyanselage Shashanka Indeevara Rajapakse, Rajapakshe Babilage Sanjitha Dilan Rajapakshe, Sudu Hakuruge Dilan Priyankara Wijekoon, Mallika Gedara Gayan Sasanka Nirodha Thilakarathna, and Rajapakse Mudiyanselage Gamini Rajapakse. "Review on Targeted Drug Delivery Carriers Used in Nanobiomedical Applications." Current Nanoscience 15, no. 4 (2019): 382–97. http://dx.doi.org/10.2174/1573413714666181106114247.

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Targeted drug delivery (TDD) is an advanced and smart method of delivering drugs to the patients in a targeted sequence that increases the concentration of delivered drug only at the targeted body part of interest (organs/tissues/cells). This will in turn enhance efficacy of treatment by reducing side effects and the required dose of the drug. TDD ensures a certain defined minimally required constant amount of a therapeutic agent for a prolonged period of time to a targeted diseased area within the body. This helps maintain the required plasma and tissue drug levels in the body thereby avoidin

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Sokolov, A. V., N. N. Kostin, L. A. Ovchinnikova, Y. A. Lomakin, and A. A. Kudriaeva. "Targeted Drug Delivery in Lipid-like Nanocages and Extracellular Vesicles." Acta Naturae 11, no. 2 (2019): 28–41. http://dx.doi.org/10.32607/20758251-2019-11-2-28-41.

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The possibility of targeted drug delivery to a specific tissue, organ, or cell has opened new promising avenues in treatment development. The technology of targeted delivery aims to create multifunctional carriers that are capable of long circulation in the patients organism and possess low toxicity at the same time. The surface of modern synthetic carriers has high structural similarity to the cell membrane, which, when combined with additional modifications, also promotes the transfer of biological properties in order to penetrate physiological barriers effectively. Along with artificial nan

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21

P. Selvakumar, Arvinder Kour Mehta, Shiney Chib, Santosh Kumar Nathsharma, T. C. Manjunath, and Sandeep Gupta. "Nanotechnology as Delivery Vehicles for Antiviral Drug Delivery Systems: A Review." Journal of Environmental Nanotechnology 14, no. 2 (2025): 216–26. https://doi.org/10.13074/jent.2025.06.2511176.

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Antiviral drug delivery systems are pivotal in the ongoing battle against viral infections, which remain a significant global health challenge. The complexity of designing effective antiviral drug delivery systems stems from the need to target viral pathogens precisely while minimizing adverse effects on host cells. One of the foremost challenges in antiviral drug delivery is achieving selective targeting of the virus without causing systemic toxicity. It is particularly challenging because many viruses can rapidly mutate, potentially rendering existing drugs less effective. Furthermore, the v

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22

Tian, Tian, Jian Ruan, Jia Zhang, Chun-Xia Zhao, Dong Chen, and Jianzhen Shan. "Nanocarrier-Based Tumor-Targeting Drug Delivery Systems for Hepatocellular Carcinoma Treatments: Enhanced Therapeutic Efficacy and Reduced Drug Toxicity." Journal of Biomedical Nanotechnology 18, no. 3 (2022): 660–76. http://dx.doi.org/10.1166/jbn.2022.3297.

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Hepatocellular carcinoma (HCC), due to the lack of efficient diagnostic methods and short of available treatments, becomes the third main cause of cancer deaths. Novel treatments for HCCs are thus in great need. The fast-growing area of drug delivery provides intriguing possibility to design nanocarriers with unique properties. The nanocarriers performanced as drug deliver vehicles enable the design of diverse drug delivery systems, which could serve multiple purposes, including improved bioavailability, controlled or triggered release and targeted delivery, leading to enhanced drug efficacy a

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23

White, Jeffrey, Huawei Wang, Flavia Franco Da Cunha, Maureen Ruchhoeft, and Richard Klemke. "Abstract 3519: Bioengineering enucleated cell vehicles for targeted delivery of Interleukin 12 to metastatic tumors." Cancer Research 82, no. 12_Supplement (2022): 3519. http://dx.doi.org/10.1158/1538-7445.am2022-3519.

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Abstract Metastatic triple negative breast cancer (TNBC) includes poor prognoses and limited effective therapies. Metastasis is the major barrier to durable clinical responses as many patients appear cured of their disease, yet return to clinic with recurrences from dormant micro-metastases. Immune activating agents, such as Interleukin 12 (IL-12) have attracted attention as anti-cancer adjuvants due to their ability to elicit systemic anti-cancer immunity. Although targeting distributed metastases can be accomplished by intravenous (IV) administration, administration of IL-12 into patient vas

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Panda, Jiban J., Ankur Kaul, Santosh Kumar, et al. "Modified dipeptide-based nanoparticles: vehicles for targeted tumor drug delivery." Nanomedicine 8, no. 12 (2013): 1927–42. http://dx.doi.org/10.2217/nnm.12.201.

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25

Pan, Victor, Preethi N. Siva, Christa L. Modery-Pawlowski, Ujjal Didar Singh Sekhon, and Anirban Sen Gupta. "Targeted killing of metastatic cells using a platelet-inspired drug delivery system." RSC Advances 5, no. 57 (2015): 46218–28. http://dx.doi.org/10.1039/c5ra05339k.

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Pro-metastatic tumor cells in circulation interact with active platelets that mediate various mechanisms of hematologic metastasis. Elucidating and utilizing these interactions on delivery vehicles can provide unique ways of metastasis-targeted drug delivery.

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Kipshidze, Nicholas, Patrick Iversen, Thomas R. Porter, et al. "Targeted, Site-Specific, Delivery Vehicles of Therapeutics for COVID-19 Patients. Brief Review." Clinical and Applied Thrombosis/Hemostasis 26 (January 1, 2020): 107602962095491. http://dx.doi.org/10.1177/1076029620954911.

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Definitive pharmacological therapies for COVID-19 have yet to be identified. Several hundred trials are ongoing globally in the hope of a solution. However, nearly all treatments rely on systemic delivery but COVID-19 damages the lungs preferentially. The use of a targeted delivery approach is reviewed where engineered products are able to reach damaged lung tissue directly, which includes catheter-based and aerosol-based approaches. In this review we have outlined various target directed approaches which include microbubbles, extracellular vesicles including exosomes, adenosine nanoparticles,

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White, Jeffrey, Huawei Wang, Flavia Franco Da Cunha, Maureen Ruchhoeft, and Richard Klemke. "Abstract 378: Bioengineering enucleated cell vehicles for tumor targeted intravenous delivery of oncolytic viruses." Cancer Research 82, no. 12_Supplement (2022): 378. http://dx.doi.org/10.1158/1538-7445.am2022-378.

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Abstract Metastatic triple negative breast cancer (TNBC) includes poor prognoses and limited effective therapies. The prevalence of systemic micro-metastases is a major barrier to achieving durable clinical outcomes. Oncolytic viruses (OVs) have garnered attention as anti-cancer adjuvants due to their potential for systemic delivery and ability to lyse tumor cells while leaving healthy cells unaffected. Clinical trials have been conducted testing the efficacy of OVs on diverse cancers. Although targeting distributed metastases can be accomplished by intravenous (IV) administration, administrat

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Steenekamp, Eunice Maureen, Wilna Liebenberg, Hendrik J. R. Lemmer, and Minja Gerber. "Formulation and Ex Vivo Evaluation of Ivermectin Within Different Nano-Drug Delivery Vehicles for Transdermal Drug Delivery." Pharmaceutics 16, no. 11 (2024): 1466. http://dx.doi.org/10.3390/pharmaceutics16111466.

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Background/Objectives: Ivermectin gained widespread attention as the “miracle drug” during the coronavirus disease 2019 (COVID-19) pandemic. Its inclusion in the 21st World Health Organization (WHO) List of Essential Medicines is attributed to its targeted anti-helminthic response, high efficacy, cost-effectiveness and favorable safety profile. Since the late 2000s, this bio-inspired active pharmaceutical ingredient (API) gained renewed interest for its diverse therapeutic capabilities. However, producing ivermectin formulations does remain challenging due to its poor water solubility, resulti

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Ismail Y and Kishore S. "Recent Advances in Targeted Drug Delivery Systems." Journal of Pharma Insights and Research 3, no. 2 (2025): 031–42. https://doi.org/10.69613/q3mj7z06.

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Targeted drug delivery helps in precise medication delivery to specific organs while minimizing adverse effects on healthy tissues. The evolution of nanocomposite materials has significantly enhanced drug delivery capabilities, offering improved drug-loading efficiency, biocompatibility, and controlled release properties. Various delivery vehicles, including colon-specific systems, liposomes, hydrogels, microfluidics, niosomes, biodegradable particles, microalgae-based carriers, artificial DNA nanostructures, quantum dots, microspheres, and modified plasma proteins, have demonstrated promising

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Boehm-Davis, Deborah A., and Truman M. Mast. "Human Factors and Commercial Vehicle Operations." Proceedings of the Human Factors Society Annual Meeting 36, no. 15 (1992): 1078–81. http://dx.doi.org/10.1518/107118192786749711.

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The Commercial Vehicle Operations (CVO) segment of the IVHS program is targeted at users of interstate trucks, local delivery vans, buses, taxis, and emergency vehicles. Specifically, the goals of the CVO program are to improve (a) the efficiency and effectiveness of traffic management and regulatory administration by government; (b) the efficiency and effectiveness of fleet management; (c) safety for operators of commercial vehicles and others affected by them; and (d) driver performance. Although a number of technologies have been developed to support these goals, the human factors aspects o

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Pradeep Mahajan, Ajit Kulkarni, Shweta Waghdhare, Sanskruti Mahajan, and Swetha Subramanian. "Exosomes: Next generation medicine." World Journal of Advanced Research and Reviews 16, no. 1 (2022): 102–10. http://dx.doi.org/10.30574/wjarr.2022.16.1.1007.

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Extracellular vesicles (EVs) are the substances that are conveyed by most sorts of cell, which play a critical role in cell-to-cell communication. Exosomes are among the most commonly explored EVs. Exosomes contain lipids, RNAs and proteins. Many examinations have shown that exosomes derived from cells play different biological roles in normal as well as diseased condition. Recent investigations have explored exosomes as natural drug delivery vehicles, as they have ability to deliver different cargo to nearby and targeted cells with high specificity and efficiency. In the last decade, there ha

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Pradeep, Mahajan, Kulkarni Ajit, Waghdhare Shweta, Mahajan Sanskruti, and Subramanian Swetha. "Exosomes: Next generation medicine." World Journal of Advanced Research and Reviews 16, no. 1 (2022): 102–10. https://doi.org/10.5281/zenodo.7769088.

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Extracellular vesicles (EVs) are the substances that are conveyed by most sorts of cell, which play a critical role in cell-to-cell communication. Exosomes are among the most commonly explored EVs. Exosomes contain lipids, RNAs and proteins. Many examinations have shown that exosomes derived from cells play different biological roles in normal as well as diseased condition. Recent investigations have explored exosomes as natural drug delivery vehicles, as they have ability to deliver different cargo to nearby and targeted cells with high specificity and efficiency. In the last decade, there ha

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Huang, Xin, Wei Wu, Doudou Jing, et al. "Engineered exosome as targeted lncRNA MEG3 delivery vehicles for osteosarcoma therapy." Journal of Controlled Release 343 (March 2022): 107–17. http://dx.doi.org/10.1016/j.jconrel.2022.01.026.

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Gao, Yifan, Jing Wang, Dengfeng Hu, et al. "Bacteria-Targeted Supramolecular Photosensitizer Delivery Vehicles for Photodynamic Ablation Against Biofilms." Macromolecular Rapid Communications 40, no. 4 (2018): 1800763. http://dx.doi.org/10.1002/marc.201800763.

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Neha, Borse* Lakshman Khochage Dr. N. B. Chougule. "Application Of Antibody in Targeted Drug Delivery System." International Journal of Pharmaceutical Sciences 2, no. 12 (2024): 1170–92. https://doi.org/10.5281/zenodo.14360661.

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Targeted drug delivery has been transformed by monoclonal antibodies (mAbs), which use their high specificity to target cells or tissues. The use of antibodies in targeted drug delivery systems is examined in this review, with an emphasis on how they can improve therapeutic efficacy and lessen side effects. We go over how antibodies can be encapsulated in delivery vehicles like liposomes and nanoparticles or conjugated to medications. We also look at the difficulties and potential applications of antibody-mediated drug delivery, such as the creation of new targeting ligands and the incorporati

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Merino, Virginia, Ingo Alberti, Yogeshvar N. Kalia, and Richard H. Guy. "Transdermal and Skin-Targeted Drug Delivery." Journal of Cutaneous Medicine and Surgery 2, no. 2 (1997): 108–19. http://dx.doi.org/10.1177/120347549700200212.

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Background: The application of therapeutic agents to the skin addresses three general objectives: (a) the treatment of a variety of dermatologic diseases; (b) the “targeted” delivery of drugs to deeper subcutaneous tissues, with a concomitant reduction in systemic exposure; and (c) socalled transdermal administration to elicit a systemic pharmacologic effect. Objective: Recently, significant progress towards all three goals has been recorded and the level of research and development activity remains high. We aim to discuss these advances from mechanistic and clinical standpoints. Results: For

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Diksha, Desai Prachi Desai Pratiksha Salokhe Shweta Ambuskar Omkar Chavan. "Liposomes as Smart Drug Delivery Vehicles: Advances, Applications, And Future Prospects." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 1170–83. https://doi.org/10.5281/zenodo.15357151.

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Liposomes are spherical vesicles composed of one or more phospholipid bilayers that have emerged as versatile and biocompatible carriers for drug delivery. Their unique structural characteristics allow encapsulation of both hydrophilic and lipophilic drugs, enhancing solubility, stability, and targeted delivery. Over the past few decades, liposomal formulations have demonstrated significant potential in improving the therapeutic efficacy of various drugs while minimizing toxicity. This review highlights the structural and compositional aspects of liposomes, preparation methods, mechanisms of d

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Kuo, Cheng-Hsiang, Lorraine Leon, Eun Ji Chung, et al. "Inhibition of atherosclerosis-promoting microRNAs via targeted polyelectrolyte complex micelles." J. Mater. Chem. B 2, no. 46 (2014): 8142–53. http://dx.doi.org/10.1039/c4tb00977k.

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Polyelectrolyte complex micelles have great potential as gene delivery vehicles because of their ability to encapsulate charged nucleic acids forming a core by neutralizing their charge, while simultaneously protecting the nucleic acids from non-specific interactions and enzymatic degradation.

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McAndrews, Kathleen M., Fei Xiao, Antonios Chronopoulos, Valerie S. LeBleu, Fernanda G. Kugeratski, and Raghu Kalluri. "Exosome-mediated delivery of CRISPR/Cas9 for targeting of oncogenic KrasG12D in pancreatic cancer." Life Science Alliance 4, no. 9 (2021): e202000875. http://dx.doi.org/10.26508/lsa.202000875.

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CRISPR/Cas9 is a promising technology for gene editing. To date, intracellular delivery vehicles for CRISPR/Cas9 are limited by issues of immunogenicity, restricted packaging capacity, and low tolerance. Here, we report an alternative, nonviral delivery system for CRISPR/Cas9 based on engineered exosomes. We show that non-autologous exosomes can encapsulate CRISPR/Cas9 plasmid DNA via commonly available transfection reagents and can be delivered to recipient cancer cells to induce targeted gene deletion. As a proof-of-principle, we demonstrate that exosomes loaded with CRISPR/Cas9 can target t

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Lansangan, Cedric, Menka Khoobchandani, Ruchit Jain, Serge Rudensky, Christopher C. Perry, and Rameshwar Patil. "Designing Gold Nanoparticles for Precise Glioma Treatment: Challenges and Alternatives." Materials 17, no. 5 (2024): 1153. http://dx.doi.org/10.3390/ma17051153.

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Glioblastoma multiforme (GBM) is a glioma and the most aggressive type of brain tumor with a dismal average survival time, despite the standard of care. One promising alternative therapy is boron neutron capture therapy (BNCT), which is a noninvasive therapy for treating locally invasive malignant tumors, such as glioma. BNCT involves boron-10 isotope capturing neutrons to form boron-11, which then releases radiation directly into tumor cells with minimal damage to healthy tissues. This therapy lacks clinically approved targeted blood–brain-barrier-permeating delivery vehicles for the central

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Lane, D. D., D. Y. Chiu, F. Y. Su, et al. "Well-defined single polymer nanoparticles for the antibody-targeted delivery of chemotherapeutic agents." Polymer Chemistry 6, no. 8 (2015): 1286–99. http://dx.doi.org/10.1039/c4py01250j.

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Feng, Jie, Zhen Xu, Ping Dong, et al. "Stimuli-responsive multifunctional metal–organic framework nanoparticles for enhanced chemo-photothermal therapy." Journal of Materials Chemistry B 7, no. 6 (2019): 994–1004. http://dx.doi.org/10.1039/c8tb02815j.

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Pagar, Namrata*1 Nikam Harshada2. "Review On Nanoparticle : Nano Vehicles For Anticancer Drugs." International Journal in Pharmaceutical Sciences 2, no. 10 (2024): 717–23. https://doi.org/10.5281/zenodo.13926263.

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The Development of nanoparticles based drug delivery systems has emerged as a promising stratergy in the fight against cancer. These nano vehicles offer several advantages over traditional chemotherapy, including targeted drug delivery reduces side effect and improved therapeautic efficacy. These various explores the various type of nano particle used for anticancer drug delivery such as liposomes, dendrimers, polymeric nano particle Their mechanism of action including enhanced permeability and retention effect, Active targetting via ligand receptor interactions and stimuli responsive release.

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Nag, Okhil K., and James B. Delehanty. "Special Issue “Nanoparticle-Mediated Drug Delivery, Imaging, and Control of Cellular Functions”." Pharmaceuticals 16, no. 10 (2023): 1344. http://dx.doi.org/10.3390/ph16101344.

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Huang, Chiung-Hua, Ting-Ju Chuang, Cherng-Jyh Ke, and Chun-Hsu Yao. "Doxorubicin–Gelatin/Fe3O4–Alginate Dual-Layer Magnetic Nanoparticles as Targeted Anticancer Drug Delivery Vehicles." Polymers 12, no. 8 (2020): 1747. http://dx.doi.org/10.3390/polym12081747.

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In this study, magnetic nanoparticles composed of a core (doxorubicin–gelatin) and a shell layer (Fe3O4–alginate) were developed to function as targeted anticancer drug delivery vehicles. The anticancer drug doxorubicin (DOX) was selected as a model drug and embedded in the inner gelatin core to obtain high encapsulation efficiency. The advantage of the outer magnetic layer is that it targets the drug to the tumor tissue and provides controlled drug release. The physicochemical properties of doxorubicin–gelatin/Fe3O4–alginate nanoparticles (DG/FA NPs) were characterized using scanning electron

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Yu, Xiaojiao, Ian Trase, Muqing Ren, Kayla Duval, Xing Guo, and Zi Chen. "Design of Nanoparticle-Based Carriers for Targeted Drug Delivery." Journal of Nanomaterials 2016 (2016): 1–15. http://dx.doi.org/10.1155/2016/1087250.

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Nanoparticles have shown promise as both drug delivery vehicles and direct antitumor systems, but they must be properly designed in order to maximize efficacy. Computational modeling is often used both to design new nanoparticles and to better understand existing ones. Modeled processes include the release of drugs at the tumor site and the physical interaction between the nanoparticle and cancer cells. In this paper, we provide an overview of three different targeted drug delivery methods (passive targeting, active targeting, and physical targeting) and compare methods of action, advantages,

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Witika, Bwalya A., Pedzisai A. Makoni, Larry L. Mweetwa, et al. "Nano-Biomimetic Drug Delivery Vehicles: Potential Approaches for COVID-19 Treatment." Molecules 25, no. 24 (2020): 5952. http://dx.doi.org/10.3390/molecules25245952.

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The current COVID-19 pandemic has tested the resolve of the global community with more than 35 million infections worldwide and numbers increasing with no cure or vaccine available to date. Nanomedicines have an advantage of providing enhanced permeability and retention and have been extensively studied as targeted drug delivery strategies for the treatment of different disease. The role of monocytes, erythrocytes, thrombocytes, and macrophages in diseases, including infectious and inflammatory diseases, cancer, and atherosclerosis, are better understood and have resulted in improved strategie

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Li, Tianzhong, Linfeng Huang, and Mengsu Yang. "Lipid-based Vehicles for siRNA Delivery in Biomedical Field." Current Pharmaceutical Biotechnology 21, no. 1 (2020): 3–22. http://dx.doi.org/10.2174/1389201020666190924164152.

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Background: Genetic drugs have aroused much attention in the past twenty years. RNA interference (RNAi) offers novel insights into discovering potential gene functions and therapies targeting genetic diseases. Small interference RNA (siRNA), typically 21-23 nucleotides in length, can specifically degrade complementary mRNA. However, targeted delivery and controlled release of siRNA remain a great challenge. Methods: Different types of lipid-based delivery vehicles have been synthesized, such as liposomes, lipidoids, micelles, lipoplexes and lipid nanoparticles. These carriers commonly have a c

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Kim, Sehwan, Sung Hun Kang, Soo Hwan Byun, et al. "Intercellular Bioimaging and Biodistribution of Gold Nanoparticle-Loaded Macrophages for Targeted Drug Delivery." Electronics 9, no. 7 (2020): 1105. http://dx.doi.org/10.3390/electronics9071105.

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In order to effectively apply nanoparticles to clinical use, macrophages have been used as vehicles to deliver genes, drugs or nanomaterials into tumors. In this study, the effectiveness of macrophage as a drug delivery system was validated by biodistribution imaging modalities at intercellular and ex vivo levels. We focused on biodistribution imaging, namely, the characterization of the gold nanoparticle-loaded macrophages using intracellular holotomography and target delivery efficiency analysis using ex vivo fluorescence imaging techniques. In more detail, gold nanoparticles (AuNPs) were pr

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Lamb, Jennifer, Eliane Fischer, Martin Rosillo-Lopez, Christoph G. Salzmann, and Jason P. Holland. "Multi-functionalised graphene nanoflakes as tumour-targeting theranostic drug-delivery vehicles." Chemical Science 10, no. 38 (2019): 8880–88. http://dx.doi.org/10.1039/c9sc03736e.

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Graphene nanoflakes with pristine aromatic surfaces and polycarboxylated edges have been modified with up to four components for potential use as targeted cancer imaging and therapeutic (theranostic) agents.

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