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Relevant bibliographies by topics / Targeted Halo-Plex™ capturing technology

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Academic literature on the topic 'Targeted Halo-Plex™ capturing technology'

Author: Grafiati

Published: 11 March 2023

Last updated: 31 July 2025

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Journal articles on the topic "Targeted Halo-Plex™ capturing technology"

1

Schwarz, J. Spencer, Matthew H. Ingalls, Xenia Meshik, Adam Northcutt, and Oliver Braubach. "Abstract 1042: Multi-exposure high dynamic range microscopy obviates the requirement for matching camera exposure to reagent concentration in high-plex spatial biology applications." Cancer Research 84, no. 6_Supplement (2024): 1042. http://dx.doi.org/10.1158/1538-7445.am2024-1042.

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Abstract High-plex immunofluorescence imaging allows researchers to perform deep cellular phenotyping with spatial context. However, high-plex immunofluorescence imaging requires the end user to painstakingly optimize antibody concentrations and image acquisition settings before producing reproducible imaging data with sufficient and quantifiable dynamic range. Mismatches of reagent concentration and camera exposures will result in under and over-saturated images, and both outcomes are detrimental for signal quantification and downstream interpretation. As the number of markers deployed in spa

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Mints, Michael, Ettai Markovits, Ron Elran, et al. "Abstract 754: AI-powered spatial inference platform for qualifying ADCs and multispecific therapeutic targets." Cancer Research 85, no. 8_Supplement_1 (2025): 754. https://doi.org/10.1158/1538-7445.am2025-754.

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Abstract Over the past two decades, genomic alterations have become important biomarkers for predicting response to targeted therapies; however, the emergence of immunotherapy, antibody-drug conjugates and multispecifics may require a different class of biomarkers that can quantify and localize drug targets within tumor and immune cells. Genomic testing frequently lacks correlation with protein expression, fails to capture membranous versus cytoplasmic localization, and has limited ability to decipher spatial interactions between targets. Multiplex immunofluorescence (mIF) is an established te

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Badar, Sadaf, Fabiana Busti, Giampiero Zamperin, et al. "Targeted Next Generation Sequencing of the Five Hemochromatosis Genes in Italian Patients with Iron Overload and Non-Diagnostic First Level Genetic Test: A Pilot Study." Blood 124, no. 21 (2014): 4030. http://dx.doi.org/10.1182/blood.v124.21.4030.4030.

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Abstract Background and Aim: Molecular diagnosis of HFE-related hereditary hemochromatosis (HH) is typically made by searching for the C282Y and H63D mutations (first level genetic test). However, in the Mediterranean area up to one third of patients with HH phenotype do not have the “diagnostic” genotypes (C282Y homozygosity, or C282Y/H63D compound heterozygosity). This pilot study was designed to develop a “second level” next generation sequencing (NGS)-based test for rapid and simultaneous analysis of the five HH genes (HFE, HFE2, HAMP, TFR2 and SLC40A1). Methodology: we studied 61 patients

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Reeves, Jason, Michael Mints, Ettai Markovits, et al. "Qualifying ADCs and multispecific therapeutic targets with a novel Agentic AI Insight platform." Journal of Clinical Oncology 43, no. 16_suppl (2025). https://doi.org/10.1200/jco.2025.43.16_suppl.e15179.

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e15179 Background: While genomic alterations are critical biomarkers for predicting response to targeted therapies, several novel classes of therapeutics may need to leverage additional contexts to qualify potential response and resistance mechanisms. Immunotherapies, antibody-drug conjugates and multispecifics may require biomarkers that localize drug targets within tumor and immune cells both in the tumor microenvironment as well as subcellular localization. Multiplex immunofluorescence (mIF) is an established technology capable of quantifying the subcellular localization of dozens of protei

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Dissertations / Theses on the topic "Targeted Halo-Plex™ capturing technology"

1

Badar, Sadaf. "Targeted Next Generation Sequencing of the Five Hemochromatosis Genes in Italian Patients with Iron Overload and Non-Diagnostic First Level Genetic Test: A Pilot Study." Doctoral thesis, 2015. http://hdl.handle.net/11562/909987.

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L’Emocromatosi Ereditaria (EE) è una delle malattie genetiche più comuni nella popolazione caucasica con un’incidenza di 5 malati su 1000 individui (0.5 %). La diagnosi precoce della malattia è di fondamentale importanza per il trattamento dei pazienti ed è stata notevolmente migliorata con la scoperta del gene HFE nel 1996 e con il successivo sviluppo di un semplice test genetico-molecolare delle mutazioni C282Y e H63D sul gene HFE. La maggior parte degli individui con EE sono omozigoti per la mutazione C282Y o eterozigoti composti C282Y/H63D, i due genotipi considerati diagnostici per l’Emoc

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