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Dissertations / Theses on the topic 'Targetted liposome'

Author: Grafiati

Published: 4 June 2021

Last updated: 3 February 2022

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1

Baki, Mert. "Bone Marrow Targeted Liposomal Drug Delivery Systems." Master's thesis, METU, 2011. http://etd.lib.metu.edu.tr/upload/12613251/index.pdf.

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Homing is the process that stem cells move to their own stem cell niches under the influence of chemokines like stromal-derived factor-1&alpha<br>(SDF-1&alpha<br>) upon bone marrow transplantation (BMT). There is a need for increasing homing efficiency after BMT since only 10-15% of the transplanted cells can home to their own niches and a limited amount of donor marrow can be transplanted. In this study, we aimed to develop and characterize bone marrow targeted liposomal SDF-1&alpha<br>delivery system prepared by extrusion method. Alendronate conjugation was chosen to target the liposomes to

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2

Loughrey, Helen. "Targeted liposomes." Thesis, University of British Columbia, 1989. http://hdl.handle.net/2429/29180.

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This thesis presents an optimized and general procedure for coupling proteins to liposomes and investigates certain aspects of the interaction of liposomes with components of the circulation. The object of these studies was to develop straightforward methods for the preparation of well characterized protein-liposome conjugates which exhibit extended circulation half-lives in the blood. These favorable properties should potentiate the use of protein coupled vesicles in in vivo applications such as targeting or diagnostic protocols. A general approach for the preparation of protein-liposome conj

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3

Harasym, Troy O. "Antibody-targeted liposomal systems." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/nq25066.pdf.

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4

Bowen, Tian. "Liposome-QD hybrids and the development of targeted theranostic modalities." Thesis, University of London, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.535499.

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5

Javadi, Marjan. "Novel Liposomes for Targeted Delivery of Drugs and Plasmids." BYU ScholarsArchive, 2013. https://scholarsarchive.byu.edu/etd/3879.

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People receiving chemotherapy not only suffer from side effects of therapeutics but also must buy expensive drugs. Targeted drug and gene delivery directed to specific tumor-cells is one way to reduce the side effect of drugs and use less amount of therapeutics. In this research, two novel liposomal nanocarriers were developed. This nanocarrier, called an eLiposome, is basically one or more emulsion droplets inside a liposome. Emulsion droplets are made of perfluorocarbons which usually have a high vapor pressure. Calcein (as a model drug) and Paclitaxel were used to demonstrate drug delivery,

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6

Harrington, Kevin Joseph. "Pegylated Liposome-targeted Radiosensitisers for the Treatment of Head and neck Cancer." Thesis, Imperial College London, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.506160.

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7

Divi, Murali Krishna. "Development and evaluation of brain tumor targeted liposome delivery system for paclitaxel." View the abstract Download the full-text PDF version, 2008. http://etd.utmem.edu/ABSTRACTS/2007-012-Divi-index.html.

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Thesis (Ph.D.)--University of Tennessee Health Science Center, 2008.<br>Title from title page screen (viewed on January 6, 2009). Research advisor: George C Wood, Ph.D. Document formatted into pages (xii, 126 p. : ill.). Vita. Abstract. Includes bibliographical references (p. 112-126).

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8

Stevens, Phillip James. "An approach to drug formulation and targeting liposomes and lipid nanoparticles for folate receptor targeting." Connect to this title online, 2005. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1111092653.

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Thesis (Ph. D.)--Ohio State University, 2005.<br>Title from first page of PDF file. Document formatted into pages; contains xvi, 110 p.; also includes graphics (some col.) Includes bibliographical references (p. 98-110). Available online via OhioLINK's ETD Center

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9

Hartley, Jonathan Michael. "Surface Modification of Liposomes Containing Nanoemulsions." BYU ScholarsArchive, 2011. https://scholarsarchive.byu.edu/etd/2846.

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Many attempts have been made to make cancer therapy more selective and less detrimental to the health of the patients. Nanoparticles have emerged as a way to solve some of the problems of traditional chemotherapy. Nanoparticles can provide protection for the therapeutic from degradation or clearance, as well as protection to healthy tissue from the damaging effects of chemotherapy drugs. Researchers are pursuing different strategies but all have the same goals of improving the outcomes of cancer patients. The field of controlled release of drugs has increased significantly in hopes of better t

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10

Jayanna, Prashanth K. Petrenko Valery. "Therapeutic liposomes for prostate cancer targeted by phage fusion coat proteins." Auburn, Ala., 2009. http://hdl.handle.net/10415/1994.

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11

Kaimal, Vinod. "In vivo MR microscopy of tumor-targeted liposome combining USPIO and saposin-C." Cincinnati, Ohio : University of Cincinnati, 2007. http://www.ohiolink.edu/etd/view.cgi?ucin1195496800.

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Thesis (Ph.D.)--University of Cincinnati, 2007.<br>Advisor: Scott K. Holland. Title from electronic thesis title page (viewed Feb. 18, 2008). Keywords: USPIO; Saposin-C; liposome; magnetic resonance imaging; MRI. Includes abstract. Includes bibliographical references.

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12

Huang, Guofeng. "ENGINEERING RGD-MODIFIED LIPOSOMES FOR TARGETED DRUG DELIVERY TO ACTIVATED PLATELETS." Case Western Reserve University School of Graduate Studies / OhioLINK, 2006. http://rave.ohiolink.edu/etdc/view?acc_num=case1153187042.

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13

Triantafilllou, Georgia. "CD74 Targeted Nanoparticles as Dexamethasone Delivery System for B lymphoid Malignancies." The Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1307069335.

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14

Anderson, Keith E. "Formulation of targeted liposomes for the oral delivery of poorly-absorbed drugs." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape17/PQDD_0004/NQ34726.pdf.

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15

KAIMAL, VINOD. "In VivoMR Microscopy of Tumor Targeted Liposome Combining USPIO and Saposin-C." University of Cincinnati / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1195496800.

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16

Motala, Ismail Mohammed, and Saartjie Roux. "Formulation of an optimal non-targeted liposome preparation for fusion with tumour cell line membranes." Thesis, Nelson Mandela Metropolitan University, 2016. http://hdl.handle.net/10948/12220.

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The most common treatment used for cancer is chemotherapy. Chemotherapeutic agents have a greater affinity for rapidly dividing cells which is a characteristic of tumour cells. Although anti-cancer agents have their advantages in providing anti-cancer effects, they can be seen as highly toxic molecules posing a threat to normal healthy tissue within the human body. However, these toxic therapies need to be delivered to tumour sites without damaging healthy tissue. Liposomes can serve as a delivery system for these toxic molecules and be delivered to the tumour site via the EPR effect. Hence, l

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17

Cureton, Natalie. "Development of nanocarriers for targeted drug delivery to the placenta." Thesis, University of Manchester, 2017. https://www.research.manchester.ac.uk/portal/en/theses/development-of-nanocarriers-for-targeted-drug-delivery-to-the-placenta(696cfc4f-0bd7-4fbe-9b23-d2b83a7fec7d).html.

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Pregnancy complications such as fetal growth restriction (FGR) are often attributed to poor uteroplacental blood flow, but the risk of systemic side-effects hinders therapeutic intervention. We have utilised novel placental-specific homing peptides to overcome this and have conjugated these to biocompatible liposomes. Peptide-conjugated liposomes were found to selectively bind to the outer syncytiotrophoblast layer of the human placenta and to the uteroplacental vasculature and labyrinth region of the mouse placenta. The novel vasodilator SE175 was selected as a nitric oxide donor with a favou

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18

Riviere, Kareen. "Investigation of the enhancement of drug synergy by co-delivery in targeted liposomes." Diss., Search in ProQuest Dissertations & Theses. UC Only, 2009. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3390075.

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19

Zhang, Xin. "Development of thermal sensitive liposomes for targeted delivery and controlled release of drug." Thesis, Imperial College London, 2014. http://hdl.handle.net/10044/1/25125.

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One of the clinical challenges in the treatment of diseases with a discrete distribution is the local delivery of active drugs without causing systemic side effects. Doxorubicin, an anti-cancer drug, is an example that may cause damage to patients due to its interaction with normal cells. Tissue plasminogen activator (tPA) is another active agent whose effectiveness is compromised due to its unselective effect on both healthy and pathological blood clots. Thermal sensitive liposome is a drug carrier that is not only able to entrap drug into it hydrophilic interior but can also release encapsul

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20

Helfrich, Marcus Robert. "Preliminary investigations into the development of novel layered phosphonic acid vesicles for targeted drug delivery applications /." view abstract or download file of text, 2002. http://wwwlib.umi.com/cr/uoregon/fullcit?p3045088.

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Thesis (Ph. D.)--University of Oregon, 2002.<br>Typescript. Includes vita and abstract. Includes bibliographical references (leaves 184-193). Also available for download via the World Wide Web; free to University of Oregon users. Address: http://wwwlib.umi.com/cr/uoregon/fullcit?p3045088.

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21

Catania, Rosa. "Glycoligands for targeted liposomes : design, development and ab-initio understanding of cell-vesicle recognition." Thesis, University of Nottingham, 2018. http://eprints.nottingham.ac.uk/49885/.

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In nature, several known proteins are glycosylated, and carbohydrate-cell receptor interactions mediate a plethora of key biological events, e.g. parasitisation and immune responses. Cell membranes display carbohydrate-binding proteins (lectins), which are able to selectively recognise specific sugar-ligands, decipher sugar-encoded instructions, and convert them into downstream biological processes. To overcome low binding affinities, which are typically observed for simple monosaccharides, protein-binding sugars are typically displayed within large multivalent ligands, where biological system

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22

Lattin, James R. "Ultrasound-Induced Phase Change of Emulsion Droplets for Targeted Gene and Drug Delivery." BYU ScholarsArchive, 2012. https://scholarsarchive.byu.edu/etd/3377.

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This dissertation explores the potential of using perfluorocarbon emulsion droplets to add an ultrasound-sensitive element to drug delivery systems. These emulsion droplets may be induced to vaporize with ultrasound; during the rarefactional phase of an ultrasound wave, the pressure around the droplets may fall below the vapor pressure of the liquid forming the emulsion, providing a thermodynamic potential for vaporization. This ultrasound-induced phase change of the emulsion droplet could release therapeutics attached to the droplet surface or aid in drug delivery due to mechanical effects as

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23

Iden, Debbie Lynne. "A novel method to prepare ligand-targeted liposomal drugs for clinical applications." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/MQ60440.pdf.

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24

Barea, Matthew Ernest John. "An investigation into liposomal formulations for targeted drug delivery to the colon." Thesis, University of Birmingham, 2012. http://etheses.bham.ac.uk//id/eprint/3430/.

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Recent studies have shown the numerous advantages associated with specific drug delivery to the colon, highlighting its favourable conditions and long transit time as the main advantages. A number of in vitro studies also show that the delivery of liposomes to the colon could provide further advantages due to bonding to the colonic mucosa in both healthy and inflamed regions. Despite these apparent advantages no oral liposomal formulation has been developed for targeted delivery to the colon as yet. Initially, experiments were conducted in which liposomes were directly coated with the pH respo

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25

Sodha, Anirudhasingh. "DEVELOPMENT AND COMMERCIALIZATION OF HEPATOCYTE TARGETED DRUG DELIVERY VEHICLE FOR PHARMACEUTICAL APPLICATION." Case Western Reserve University School of Graduate Studies / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=case1247192896.

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26

Mao, Yicheng. "Monoclonal Antibody and Liposomal Nanoparticle-based Targeting Therapies for Chronic Lymphocytic Leukemia." The Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1354299911.

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27

Chu, Hanwen [Verfasser]. "Prospect application of magneto-enzymatic sensitive liposome for imaging and targeted release in oral squamous cell carcinoma / Hanwen Chu." Kiel : Universitätsbibliothek Kiel, 2019. http://d-nb.info/119117980X/34.

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28

Zhang, Xue. "Development of a targeted liposomal delivery system for encapsulated cantharidin to treat hepatocellular carcinoma." HKBU Institutional Repository, 2017. https://repository.hkbu.edu.hk/etd_oa/429.

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Background: Despite increasing incidence and morbidity globally, hepatocellular carcinoma (HCC) remains a big challenge clinically. The difficulty to treat HCC is largely due to non-specific chemotherapy causing life-threatening toxicity and severe drug-related adverse effects. Extensive studies on targeted drug delivery systems (DDS) have revealed a great potential in specific delivery of chemotherapeutics for cancer treatment, which should be a way to overcome the limitations of conventional chemotherapy. Cantharidin (CTD) is a natural product from Chinese medicine showing a great potency bu

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29

Zhao, Xiaobin. "Targeting CD37 and folate receptor for cancer therapy strategies based on engineered protein and liposomes /." Columbus, Ohio : Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1174678307.

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30

Lyon, P. C. "Targeted release from lyso-thermosensitive liposomal doxorubicin (ThermoDox®) using focused ultrasound in patients with liver tumours." Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:4817361a-e7f8-4773-ac81-8445ace05301.

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31

Kheradmandi, Mahsa. "Surface and Structural Engineering of Liposomes and Cell-Derived Vesicles for Targeted Drug Delivery and Membrane Mimetics Design." Ohio University / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1624556116164427.

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32

Rohrbach, Florian. "Induction of anti-tumor immunity by targeted delivery of ErbB2 cancer vaccines to antigen-presenting cells." Université Louis Pasteur (Strasbourg) (1971-2008), 2004. http://www.theses.fr/2004STR13026.

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33

Rosano, Jenna Marie. "Engineering Nanoparticles for Targeted Delivery of Growth Factors to Prevent Cardiac Remodeling After an MI." Master's thesis, Temple University Libraries, 2010. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/82332.

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Mechanical Engineering<br>M.S.E.<br>Myocardial infarction (MI) is a leading cause of death in the United States, claiming the lives of approximately 500,000 people each year. The infarcted heart undergoes a compensatory process called cardiac remodeling, which adversely changes left ventricular (LV) size and function and eventually may lead to heart failure. To date, the only clinical treatments for this condition include surgical restoration of blood flow to the ischemic region (e.g., angioplasty), or pharmacological treatments (e.g., angiotensin converting enzyme inhibitors) which indirectly

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34

CHANTARASRIVONG, CHANIKARN. "Development and evaluation of novel structurally simplified sialyl LewisX mimic-decorated liposomes for targeted drug delivery to E-selectin-expressing endothelial cells." Kyoto University, 2019. http://hdl.handle.net/2433/242670.

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35

Dattani, Poonam. "Development and Characterization of LDV Peptide Targeted Nanocarriers for Paclitaxel Delivery: A Comparative Study of Micelles, Liposomes and Solid Lipid Nanoparticles." Scholarly Commons, 2019. https://scholarlycommons.pacific.edu/uop_etds/3623.

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Nanocarriers have been established as delivery vehicles to target cancer tumors. However, premature drug leakage is one of the major reasons for inefficient drug delivery of nanocarriers to the tumor. Drug diffusion out of the nanocarriers or destabilization of drug loaded nanocarriers by physiological interactions with blood cells, serum proteins, and cell membranes upon systemic administration contribute to premature drug release. In this study, targeted micelles, liposomes and solid lipid nanoparticles (SLNs) of similar composition were prepared and characterized to compare physicochemical

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Hendricks, Gabriel L. "Modulating Influenza and Heparin Binding Viruses’ Pathogenesis with Extrinsic Receptor Decoy Liposomes: A Dissertation." eScholarship@UMMS, 2013. http://escholarship.umassmed.edu/gsbs_diss/674.

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Influenza is a severe disease in humans and animals, causing upwards of 40,000 deaths every year in America alone. Influenza A virus (IAV) also causes periodic pandemics every 10 to 50 years, killing millions of people. Despite this, very few effective therapies are available. All strains of IAV are prone to developing resistance to antibodies due to the high mutation rate in the viral genome. Because of this mutation rate, a yearly vaccine must be generated before every flu season, and efficacy varies year to year. IAV has also mutated to escape several of the clinically-approved small molecu

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Moles, Meler Ernest. "Development of polyvalent erythrocyte- and parasitized erythrocyte-targeted nanovectors as novel site-specific drug delivery approaches for Plasmodium falciparum malaria chemotherapy." Doctoral thesis, Universitat de Barcelona, 2015. http://hdl.handle.net/10803/360333.

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Bearing in mind the absence of an effective preventive vaccine against malaria (WHO, 2015) and its severe clinical manifestations that are principally associated with red blood cell (RBC) destruction and parasitized-RBC (pRBC) cytoadherence to host cells causing in turn nearly half a million deaths every year, this disease represents nowadays a major threat to life and consequently its control and ultimate global eradication must be undertaken without preconceptions. Additionally, the basic rationale followed by most of the currently marketed antimalarial approaches is based on the administ

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38

Brandao, palacio Sarah. "Development and characterization of targeted MART-1-nanoparticles for melanoma treatment and β-lapachone-loaded liposomal in hydrogel for wound healing". Thesis, Université Paris-Saclay (ComUE), 2017. http://www.theses.fr/2017SACLS487/document.

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L’objectif principal de cette thèse a été le développement, la caractérisation et l’évaluation in vitro et in vivo de différents nanovecteurs plus spécifiquement les nanoparticules spécifiques pour le traitement de la mélanome et β-lapachone-lipossomale incorporée dans des hydrogels de biopolymère pour la cicatrisation de blessures topiques. La première étape de cette thèse a consisté en la révision de la littérature liées aux résentes avancées sur les nanoparticules pour le ciblage d’agents thérapeutiques pour des cellules circulantes et des mésenchymateuses de mélanomes. De plus, cette révis

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39

Ayesa, Umme. "CHARACTERIZATION OF THERMOSENSITIVE HYBRID ARCHAEOSOMES AND DPA-CY3[22,22]/POPC LIPOSOMES AND IN VITRO EVALUATION OF THEIR POTENTIAL USEFULNESS IN TARGETED DELIVERY AND CONTROLLED RELEASE." Diss., Temple University Libraries, 2016. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/368614.

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Biochemistry<br>Ph.D.<br>One of earlier challenges in treating cancer was utilizing drugs that are powerful yet do not cause severe toxicity to patients. Although the use of liposomal drugs has somewhat met that challenge, our objective now is to create liposomal drugs with an even better drug efficacy and further reduced toxicity. Doxorubicin hydrochloride (DXO), for example, is an anticancer drug used to treat many types of cancers, but it is toxic to the gastrointestinal tract and the heart. Encapsulating DXO into liposomes as done in the first FDA-approved liposomal DXO, Doxil, minimizes t

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Elliott, John A. "PEGylation of Niosomes." Scholar Commons, 2009. http://scholarcommons.usf.edu/etd/3448.

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The research presented in this dissertation describes the creation and characterization of a novel antibody-vesicle conjugate modified with polyethylene glycol (PEG) that possesses enhanced binding to and uptake by inflammation-activated endothelial cells with improved storage stability and longer shelf-life and potential reduction in immunogenic potential compared to previous designs. Targeted drug delivery provides an effective means of delivering therapeutic concentrations of a drug to the site or organ of action. The drug is delivered using a niosome, a vesicle with an aqueous core and a b

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Sánchez, Purrà Maria. "Development of novel vesicle-like nanocarriers for targeted drug delivery." Doctoral thesis, Universitat Ramon Llull, 2015. http://hdl.handle.net/10803/288318.

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Les dificultats existents en l’administració de certs fàrmacs, que es tradueix en una considerable reducció de la seva eficàcia terapèutica, ha portat a l’exploració d’un nou camp en la recerca de fàrmacs, l’ús de polímers per a transportar fàrmacs. Aquests polímers es presenten com a vehicles transportadors que aporten protecció al fàrmac, evitant la seva degradació, i permeten la seva distribució dirigida fins la diana terapèutica, disminuint així els efectes secundaris. Una combinació adequada del polímer transportador amb el fàrmac, permet l’alliberament d’aquest en el teixit on ha de dese

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Peres, Filho Marco Júnio. "Desenvolvimento de lipossomas vetorizados ao receptor folato contendo paclitaxel e imatinibe coencapsulados: avaliação da atividade antiproliferativa e da expressão gênica do VEGF em células tumorais." Universidade Federal de Goiás, 2014. http://repositorio.bc.ufg.br/tede/handle/tede/7452.

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Submitted by JÚLIO HEBER SILVA (julioheber@yahoo.com.br) on 2017-06-09T20:26:25Z No. of bitstreams: 2 Tese - Marco Júnio Peres Filho - 2014.pdf: 2890867 bytes, checksum: 94c9616394d6a389aadabf3d9a0b128c (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5)<br>Approved for entry into archive by Luciana Ferreira (lucgeral@gmail.com) on 2017-06-12T12:31:24Z (GMT) No. of bitstreams: 2 Tese - Marco Júnio Peres Filho - 2014.pdf: 2890867 bytes, checksum: 94c9616394d6a389aadabf3d9a0b128c (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5)<br>Made availab

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Polak, Roberta. "Desenvolvimento e fabricação de filmes ultra-finos, obtidos pela técnica layer-by-layer, para aplicações na entrega direcionada de fármacos e na captura seletiva de bio-marcadores." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/9/9135/tde-27042015-152718/.

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O objetivo geral deste trabalho foi explorar a versatilidade de filmes multicamadas de polieletrólitos (PEM) e suas aplicações em sistemas de entrega de drogas e como filmes funcionais para aplicações biomédicas. Filmes PEM montados pela técnica de camada por camada (layer-by-layer, LbL), foram explorados em três aplicações principais. Na primeira, foi explorado o desenvolvimento de um protocolo de funcionalização em filmes de poli(alilamina)/poli (estireno sulfonato), PAH/SPS. Os parâmetros de construção do filme para biotinilação dos grupamentos amina do PAH foram otimizados e aplicados na

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Tseng, Yun-Long, and 曾雲龍. "Targeted Cancer Therapy with Liposomal Doxorubicin." Thesis, 1999. http://ndltd.ncl.edu.tw/handle/36883455445417114939.

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博士<br>國立臺灣大學<br>生化學研究所<br>87<br>Steric stabilization by polyethylene glycol (PEG) can reduce opsonization of the liposome by plasma proteins. It has a higher plasma area under the concentration-time curve (AUC), which is believed to correlate with better therapeutic efficacy. However, the presence of large molecules on the liposomal surface may reduce interactions of liposomes with cells and hinder the entry of liposomes into the tumor tissue. Using a stable liposomal system composed of distearoyl phosphatidylcholine (DSPC)/cholesterol, we examined the effect of PEG (mol. wt.: 2000) on the pha

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Narainpersad, Nicolisha. "Cationic liposome mediated targeted gene delivery with and without pegylated accessories." Thesis, 2009. http://hdl.handle.net/10413/8352.

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As a consequence of safety issues encountered by the use of viral vectors in gene therapy, there has been a steady increase in the development and application of non-viral vectors, especially liposomes. Cationic liposome mediated delivery is one of the most promising nonviral delivery methods. These liposomes are prepared from synthetic lipids, are positively charged and interact favourably with DNA through electrostatic interactions. Cationic liposomes have also shown immense potential in the targeting of specific cell types such as HepG2 (hepatocellular carcinoma) cells, a model in vitro gen

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Dunne, Michael. "Quantitative In Vivo Assessment of Tumour Vasculature-targeted Liposomes." Thesis, 2010. http://hdl.handle.net/1807/30116.

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Targeting angiogenic vasculature has been validated as a viable approach for cancer imaging and therapy. The tumour vasculature-specific ligand asparagine-glycine-arginine (NGR) peptide targets the isoform of aminopeptidase N (CD13) expressed on endothelial cells lining angiogenic vessels. CD13 has become widely recognized as a rational target for therapeutic development and several NGR-conjugated agents are now in pre-clinical and clinical development. In the current study, a CT image-based approach is used to evaluate the in vivo performance of several NGR-conjugated liposome formulations

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Nogueira, Eugénia Sofia Costa. "Development of folate-targeted liposomes for rheumatoid arthritis therapy." Doctoral thesis, 2015. http://hdl.handle.net/1822/40446.

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Tese de Doutoramento em Biologia Molecular e Ambiental (área de especialização em Biologia Celular e Saúde).<br>Rheumatoid arthritis is a common, chronic inflammatory and destructive arthropathy with considerable personal, social and economic implications. Although the etiology of rheumatoid arthritis remains controversial, the hallmark of the disease is characterized by symmetrical inflammation of the synovial membrane of freely moveable joints, massive synovial proliferation and influx of inflammatory cells. Methotrexate is the first line therapy, but in intolerant patients biologic agents s

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Chen, Jung-Ying, and 陳容瑩. "The study of antisense oligonucleotides delivery by Tf-targeted liposomes." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/47554709606269818458.

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碩士<br>臺北醫學大學<br>藥學研究所<br>97<br>Antisense oligonucleotides (ODN) are attractively therapeutic agents for cancer therapy. They are short fragments of nucleic acids and designed to target the complementary mRNA sequence to specifically interfere with gene expression and inhibit encoded protein production. Apoptosis is a physiological mechanism for selective elimination of cells, and regulated by the balance between many proteins during this process, such as Bcl-2, an essential inhibitory protein to apoptosis. Many cancer cells proliferate abnormally due to overexpression of Bcl-2. Therefore, to d

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49

Yang, Tzu-Sheng, and 楊子聖. "Evaluation of multi-targeted and single-targeted liposomal drug treating for gastric cancer." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/27x48f.

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碩士<br>國立臺北科技大學<br>生物科技研究所<br>95<br>Liposome as a carrier encapsulate anti-cancer drugs has always regard as an interesting topic in clinical research. In this study, we develop a targeting anti-cancer liposome that has a specific target molecule by synthesis, which has potential to directly target to the specific cancer. First, we made Octreotide and RGD respectively conjugated with DSPE-PEG, and then we made DSPE-PEG-Octreotide and DSPE-PEG-RGD integrated to lipid bilayer, which is called Octreotide(RGD)-PEG-liposome, also we encapsulated dihydrotanshinone I as the anti-cancer drug.The result

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50

Cheng, Yu Hsin, and 鄭宇欣. "Cetuximab-conjugated thermo-sensitive magnetic liposome for targeted delivery of Irinotecan in glioma treatment." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/22960061794700763749.

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