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Journal articles on the topic 'TAS1R2/TAS1R3'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Haznedaroğlu, Eda, Meliha Koldemir-Gündüz, Nur Bakır-Coşkun, et al. "Association of Sweet Taste Receptor Gene Polymorphisms with Dental Caries Experience in School Children." Caries Research 49, no. 3 (2015): 275–81. http://dx.doi.org/10.1159/000381426.

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Sweet taste is a powerful factor influencing food acceptance. The peripheral taste response to sugar is mediated by the TAS1R2/TAS1R3 taste receptors. The aim of the study was to determine the relationship between TAS1R2 (rs35874116 or rs9701796) and/or TAS1R3 (rs307355) single nucleotide polymorphisms with dental caries experience in schoolchildren. A total of 184 schoolchildren aged between 7 and 12 years (101 girls, 83 boys) were included in the study. Genomic DNA was extracted from saliva samples and the genotypes were identified by qPCR. The genotype frequencies were as follows: 6.6% for

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2

Kim, Soo-Kyung, Yalu Chen, Ravinder Abrol, William A. Goddard, and Brian Guthrie. "Activation mechanism of the G protein-coupled sweet receptor heterodimer with sweeteners and allosteric agonists." Proceedings of the National Academy of Sciences 114, no. 10 (2017): 2568–73. http://dx.doi.org/10.1073/pnas.1700001114.

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The sweet taste in humans is mediated by the TAS1R2/TAS1R3 G protein-coupled receptor (GPCR), which belongs to the class C family that also includes the metabotropic glutamate and γ-aminobutyric acid receptors. We report here the predicted 3D structure of the full-length TAS1R2/TAS1R3 heterodimer, including the Venus Flytrap Domains (VFDs) [in the closed–open (co) active conformation], the cysteine-rich domains (CRDs), and the transmembrane domains (TMDs) at the TM56/TM56 interface. We observe that binding of agonists to VFD2 of TAS1R2 leads to major conformational changes to form a TM6/TM6 in

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3

Han, Pengfei, Russell S. J. Keast, and Eugeni Roura. "Salivary leptin and TAS1R2/TAS1R3 polymorphisms are related to sweet taste sensitivity and carbohydrate intake from a buffet meal in healthy young adults." British Journal of Nutrition 118, no. 10 (2017): 763–70. http://dx.doi.org/10.1017/s0007114517002872.

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AbstractThe influence of sweet taste sensitivity on food intake is not well understood. We investigated the involvement of salivary leptin and SNP of the sweet taste receptor genes (TAS1R2/TAS1R3) on sweet taste sensitivity, sensory-specific satiety (SSS) and macronutrient intake in healthy human adults. In all, nineteen high sweet sensitivity (HS) and eleven low sweet sensitivity (LS) subjects were classified based on the sweetness perception of one solution (9 mm sucrose) forced-choice triangle test. All participants completed a randomised crossover design experiment where they consumed one

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4

Marín-Soto, María Delfina, Angel Miliar-García, Modesto Gómez-López, Ilicia González-Mundo, and Víctor Ricardo Aguilera-Sosa. "Asociación entre el “food craving” y los genes del gusto en personas con obesidad." Investigación Clínica 62, no. 2 (2021): 119–31. http://dx.doi.org/10.22209/ic.v62n2a03.

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El “food craving” (FC) es un deseo incontrolable por ingerir alimentos en específico, se activa durante la fase de abstinencia de alimentos azucarados, salados y grasos. Se ha encontrado que se relaciona con obesi-dad (OB) y con trastornos del comportamiento de la alimentación, además de ser un factor negativo para la adherencia al tratamiento de la OB. Los Food Cravings Questionnaires Trait (T-rasgo) y State (S-estado) son instrumentos validados, que miden rasgo-estado, son confiables, y con consistencia interna alta (ɑ>0,90). El objetivo de esta investigación fue analizar diferencias entr

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5

Nachtigal, Danielle, and Barry G. Green. "Sweet Thermal Taste: Perceptual Characteristics in Water and Dependence on TAS1R2/TAS1R3." Chemical Senses 45, no. 3 (2020): 219–30. http://dx.doi.org/10.1093/chemse/bjaa009.

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Abstract The initial objective of this study was to determine if activation of the sweet taste receptor TAS1R2/TAS1R3 is necessary for perception of sweet thermal taste (swTT). Our approach was to inhibit the receptor with the inverse agonist lactisole using a temperature-controlled flow gustometer. Because all prior studies of thermal taste (TT) used metal thermodes to heat the tongue tip, we first investigated whether it could be generated in heated water. Experiment 1 showed that sweetness could be evoked when deionized water was heated from 20 to 35 °C, and testing with static temperatures

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6

O’Brien, Patrick, Rhys Hewett, and Christopher Corpe. "Sugar sensor genes in the murine gastrointestinal tract display a cephalocaudal axis of expression and a diurnal rhythm." Physiological Genomics 50, no. 6 (2018): 448–58. http://dx.doi.org/10.1152/physiolgenomics.00139.2017.

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Distributed along the length of the gastrointestinal (GI) tract are nutrient sensing cells that release numerous signaling peptides influencing GI function, nutrient homeostasis and energy balance. Recent studies have shown a diurnal rhythm in GI nutrient sensing, but the mechanisms responsible for rhythmicity are poorly understood. In this report we studied murine GI sugar sensor gene and protein expression levels in the morning (7 AM) and evening (7 PM). Sweet taste receptor ( tas1r2/tas1r3/gnat3/gnat1) sugar transporter ( slc5a1, slc2a2, slc2a5) and putative sugar sensor ( slc5a4a and slc5a

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7

Jiao, Hengwu, Huan-Wang Xie, Libiao Zhang, Nima Zhuoma, Peihua Jiang, and Huabin Zhao. "Loss of sweet taste despite the conservation of sweet receptor genes in insectivorous bats." Proceedings of the National Academy of Sciences 118, no. 4 (2021): e2021516118. http://dx.doi.org/10.1073/pnas.2021516118.

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The evolution of taste perception is usually associated with the ecology and dietary changes of organisms. However, the association between feeding ecology and taste receptor evolution is unclear in some lineages of vertebrate animals. One example is the sweet taste receptor gene Tas1r2. Previous analysis of partial sequences has revealed that Tas1r2 has undergone equally strong purifying selection between insectivorous and frugivorous bats. To test whether the sweet taste function is also important in bats with contrasting diets, we examined the complete coding sequences of both sweet taste r

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8

Bertran, Laia, Marta Portillo-Carrasquer, Salomé Martínez, et al. "Expression of Jejunal Taste Receptors in Women with Morbid Obesity." Nutrients 13, no. 7 (2021): 2437. http://dx.doi.org/10.3390/nu13072437.

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Nutrient sensing plays important roles in promoting satiety and maintaining good homeostatic control. Taste receptors (TAS) are located through the gastrointestinal tract, and recent studies have shown they have a relationship with metabolic disorders. The aim of this study was to analyze the jejunal expression of TAS1R2, TAS1R3, TAS2R14 and TAS2R38 in women with morbid obesity, first classified according to metabolic syndrome presence (MetS; n = 24) or absence (non-MetS; n = 45) and then classified according to hepatic histology as normal liver (n = 28) or nonalcoholic fatty liver disease (n

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9

Melo, Silvia V., Grasiela Agnes, Márcia R. Vitolo, Vanessa S. Mattevi, Paula D. B. Campagnolo, and Silvana Almeida. "Evaluation of the association between the TAS1R2 and TAS1R3 variants and food intake and nutritional status in children." Genetics and Molecular Biology 40, no. 2 (2017): 415–20. http://dx.doi.org/10.1590/1678-4685-gmb-2016-0205.

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10

Sukumaran, Sunil K., Karen K. Yee, Shusuke Iwata та ін. "Taste cell-expressed α-glucosidase enzymes contribute to gustatory responses to disaccharides". Proceedings of the National Academy of Sciences 113, № 21 (2016): 6035–40. http://dx.doi.org/10.1073/pnas.1520843113.

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The primary sweet sensor in mammalian taste cells for sugars and noncaloric sweeteners is the heteromeric combination of type 1 taste receptors 2 and 3 (T1R2+T1R3, encoded by Tas1r2 and Tas1r3 genes). However, in the absence of T1R2+T1R3 (e.g., in Tas1r3 KO mice), animals still respond to sugars, arguing for the presence of T1R-independent detection mechanism(s). Our previous findings that several glucose transporters (GLUTs), sodium glucose cotransporter 1 (SGLT1), and the ATP-gated K+ (KATP) metabolic sensor are preferentially expressed in the same taste cells with T1R3 provides a potential

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11

Bassoli, A., G. Borgonovo, F. Caremoli, and G. Mancuso. "The taste of D- and L-amino acids: In vitro binding assays with cloned human bitter (TAS2Rs) and sweet (TAS1R2/TAS1R3) receptors." Food Chemistry 150 (May 2014): 27–33. http://dx.doi.org/10.1016/j.foodchem.2013.10.106.

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12

Perna, Simone. "Are the genes CA6, TAS2R38, TCF7L2, FTO, TAS1R2, TAS1R3, GNAT3 receptor polymorphisms involved on exceptional longevity and risk of sarcopenia? A cross sectional study in Italian aging population." Genetika 52, no. 1 (2020): 177–86. http://dx.doi.org/10.2298/gensr2001177p.

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This study hypothesized that genetic polymorphisms of different genes could modulate the lifespan and muscle health or sarcopenia. We investigated the possible associations between longevity and the common genetic variation polymorphism such as rs713598, rs7903146, rs9939609, rs35874116, rs2274333, rs7792845, rs35744813 in a population of 360 Italian elderly aged 65- 100 years. The polymorphism rs9939609, of the FTO gene, shows an association (p< 0.001) with longevity. In particular, the frequency of T/T homozygotes increases gradually from 35% in subjects aged 65-80 ys up to 80% in centena

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13

Mineev, V. N., P. V. Brukhanova, and D. E. Koksharova. "EXTRAORAL SWEET TASTE RECEPTORS IN RESPIRATORY SYSTEM." Medical academic journal 18, no. 1 (2018): 27–33. http://dx.doi.org/10.17816/maj18127-33.

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The possible pathogenetic role of extraoral sweet taste receptors Tas1R in respiratory system is considered. In many respects, the function of extraoral receptors for sweet taste still remains unclear. The mechanism of intracellular signal transduction at sweet taste reception is considered, as well as the molecular mechanism of interaction of Tas2R and Tas1R receptors, expressed on the same cell. Tas1R receptors in respiratory system can function as a “rheostat” to control the amount of secretion of antimicrobial peptides that is mediated by extraoral bitter taste receptors Tas2R, depending o

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14

Feng, Ping, and Shichu Liang. "Molecular evolution of umami/sweet taste receptor genes in reptiles." PeerJ 6 (August 24, 2018): e5570. http://dx.doi.org/10.7717/peerj.5570.

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Sensory systems play an important role in animal survival. Changes to these systems may be critical in evolution of species in new environments. Previous studies exploring the correlation between feeding ecology and Tas1r evolution mainly focused on mammals and birds, and found that the relationship was complex. However, in reptiles, the correlation between Tas1r evolution and dietary preferences is still unclear. Here, we attempted to explore this relationship in representative species of the major groups of reptiles (turtles, snakes, lizards, crocodilians), for which the genome information i

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15

Song, Xiudao, Fei Wang, Heng Xu, et al. "3-Deoxyglucosone Induces Glucagon-Like Peptide-1 Secretion from STC-1 Cells via Upregulating Sweet Taste Receptor Expression under Basal Conditions." International Journal of Endocrinology 2019 (October 23, 2019): 1–10. http://dx.doi.org/10.1155/2019/4959646.

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3-Deoxyglucosone (3DG) is derived from D-glucose during food processing and storage and under physiological conditions. We reported that glucagon-like peptide-1 (GLP-1) secretion in response to an oral glucose load in vivo and high-glucose stimulation in vitro was decreased by acute 3DG administration. In this study, we determined the acute effect of 3DG on GLP-1 secretion under basal conditions and investigated the possible mechanisms. Normal fasting rats were given a single acute intragastric administration of 50 mg/kg 3DG. Plasma basal GLP-1 levels and duodenum 3DG content and sweet taste r

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16

Ben Abu, Natalie, Philip E. Mason, Hadar Klein, et al. "Sweet taste of heavy water." Communications Biology 4, no. 1 (2021). http://dx.doi.org/10.1038/s42003-021-01964-y.

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AbstractHydrogen to deuterium isotopic substitution has only a minor effect on physical and chemical properties of water and, as such, is not supposed to influence its neutral taste. Here we conclusively demonstrate that humans are, nevertheless, able to distinguish D2O from H2O by taste. Indeed, highly purified heavy water has a distinctly sweeter taste than same-purity normal water and can add to perceived sweetness of sweeteners. In contrast, mice do not prefer D2O over H2O, indicating that they are not likely to perceive heavy water as sweet. HEK 293T cells transfected with the TAS1R2/TAS1

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17

Farinella, Riccardo, Ilaria Erbi, Alice Bedini, et al. "Polymorphic variants in Sweet and Umami taste receptor genes and birthweight." Scientific Reports 11, no. 1 (2021). http://dx.doi.org/10.1038/s41598-021-84491-4.

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AbstractThe first thousand days of life from conception have a significant impact on the health status with short, and long-term effects. Among several anthropometric and maternal lifestyle parameters birth weight plays a crucial role on the growth and neurological development of infants. Recent genome wide association studies (GWAS) have demonstrated a robust foetal and maternal genetic background of birth weight, however only a small proportion of the genetic hereditability has been already identified. Considering the extensive number of phenotypes on which they are involved, we focused on i

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18

Ahmad, Raise, and Julie E. Dalziel. "G Protein-Coupled Receptors in Taste Physiology and Pharmacology." Frontiers in Pharmacology 11 (November 30, 2020). http://dx.doi.org/10.3389/fphar.2020.587664.

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Heterotrimeric G protein-coupled receptors (GPCRs) comprise the largest receptor family in mammals and are responsible for the regulation of most physiological functions. Besides mediating the sensory modalities of olfaction and vision, GPCRs also transduce signals for three basic taste qualities of sweet, umami (savory taste), and bitter, as well as the flavor sensation kokumi. Taste GPCRs reside in specialised taste receptor cells (TRCs) within taste buds. Type I taste GPCRs (TAS1R) form heterodimeric complexes that function as sweet (TAS1R2/TAS1R3) or umami (TAS1R1/TAS1R3) taste receptors,

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