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Dissertations / Theses on the topic 'Taxol'

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Published: 4 June 2021

Last updated: 25 July 2025

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1

Lane, Charlotte Alice Louise. "Synthetic studies towards taxol." Thesis, Imperial College London, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.267854.

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2

Montaseri, Hashem. "Taxol, solubility, stability, and bioavailability." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp05/nq21604.pdf.

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3

Rodriguez, Patricia Fernandez. "Streamlined synthesis of taxol analogues." Thesis, University of Oxford, 2017. https://ora.ox.ac.uk/objects/uuid:58d4a7f3-038e-4c4a-9aec-67267277670f.

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This thesis centres on the synthesis of taxol analogues via late-stage hydroxylation with P450 enzymes. To accomplish this, the taxane core, specifically taxa-4(5),11(12)-dien-2-one, was synthesised by classical synthetic methods, and subsequently oxidised using P450<sub>BM3</sub> mutants. Chapter 1 introduces enzymatic catalysis, and the advantages and disadvantages of its application to organic synthesis. Additionally, an overview of taxol, including its discovery, mode of action, biosynthesis and large-scale production, and a summary of the previously reported approaches to the taxane core

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4

Liu, Changhui. "Syntheses and Bioactivities of Targeted and Conformationally Restrained Taxol Analogs." Diss., Virginia Tech, 2004. http://hdl.handle.net/10919/11186.

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Taxol (1) was first isolated from the bark of the Pacific yew about 35 years ago by Drs. Wall and Wani. Although its development as an anticancer agent was delayed by numerous reasons, including its scarcity and insolubility, the discovery of its tubulin-assembly activity and other factors motivated oncologists to overcome these problems. It has since become one of the most important current drugs for the treatment of several cancers, including breast and ovarian cancers. Like almost all anticancer drugs taxol does have some toxic side effects and many tumors also show significant resistance

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5

Onrubia, Ibáñez Miriam. "A molecular approach to taxol biosynthesis." Doctoral thesis, Universitat Pompeu Fabra, 2012. http://hdl.handle.net/10803/83344.

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Secondary metabolism in plants produces numerous compounds with wide-ranging activities, including the antineoplastic compound taxol and related taxanes. The biotechnological production of taxol has so far been based on empirical studies. The aim of the present work has been to study how the factors that enhance taxane production affect the metabolic profiles and gene expression in productive cells. As a consequence of this work, new potential candidates have been obtained for unknown taxane biosynthetic genes, some bottle-neck steps of taxane biosynthesis (in vitro and in silico) have been id

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6

Zhao, Zhiyang. "Studies on water-soluble taxol derivatives." Thesis, This resource online, 1991. http://scholar.lib.vt.edu/theses/available/etd-11242009-020141/.

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7

Samaranayake, Gamini S. "Studies on the chemistry of taxol." Diss., Virginia Tech, 1992. http://hdl.handle.net/10919/39708.

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The novel diterpenoid taxol isolated from the western yew Taxus brevifolia is one of the most important lead compounds to emerge from the search for anticancer agents from plants. It shows consistent clinical activity against ovarian cancer and may also be active against other cancers. In this study, the preparation of various taxol derivatives was investigated, with the objective of better understanding the structural requirements for activity in the taxol series. The 7-hydroxyl group of taxol was derivatized with a photoaffinity label and other reagents as a beginning of the project to under

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8

Rimoldi, John M. "Investigations of the chemistry of taxol." Diss., Virginia Tech, 1993. http://hdl.handle.net/10919/39739.

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9

BENGHANEM, FIRDAOUS LOUBNA. "Taxol et cancer du sein avance." Nantes, 1993. http://www.theses.fr/1993NANT038M.

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10

Elmore, Steven W. "Synthetic studies en route to taxol /." The Ohio State University, 1993. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487847761307427.

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11

Colony, James Lynn. "Studies on the biosynthesis of taxol /." Thesis, Connect to this title online; UW restricted, 2000. http://hdl.handle.net/1773/11587.

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12

Yang, Chao. "Syntheses and Bioactivities of Targeted and Conformationally Restrained Paclitaxel and Discodermolide Analogs." Diss., Virginia Tech, 2008. http://hdl.handle.net/10919/28942.

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Paclitaxel was isolated from the bark of <i>Taxus brevifolia</i> in the late 1960s. It exerts its biological effect by promoting tubulin polymerization and stabilizing the resulting microtubules. Paclitaxel has become one of the most important current drugs for the treatment of breast and ovarian cancers. Studies aimed at understanding the biologically active conformation of paclitaxel bound on β–tubulin are described. In this work, the synthesis of isotopically labeled taxol analogs is described and the REDOR studies of this compound complexed to tubulin agrees with the hypothesis that palic

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13

Rimmington, Stuart. "A radical cascade reaction approach towards Taxol." Thesis, University of Nottingham, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.479330.

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14

Santos, Ricardo Paupitz Barbosa dos. "Estudo estrutura-atividade do taxol e derivados." [s.n.], 1998. http://repositorio.unicamp.br/jspui/handle/REPOSIP/277677.

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Orientador: Douglas Soares Galvão<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Fisica Gleb Wataghin<br>Made available in DSpace on 2018-07-23T19:37:48Z (GMT). No. of bitstreams: 1 Santos_RicardoPaupitzBarbosados_M.pdf: 1477030 bytes, checksum: e7ad1f9764a814b6eef54d5741a9bc4a (MD5) Previous issue date: 1998<br>Resumo: O Taxol, substância isolada a partir da casca do Taxus brevifolia, e de outras espécies do gênero Taxus, tem sido objeto de inúmeras pesquisas nos últimos anos. Esta molécula tem sido muito estudada principalmente por ser um forte agente anti-canc

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15

Hofferberth, John E. "Progress toward the total synthesis of Taxol /." The Ohio State University, 2002. http://rave.ohiolink.edu/etdc/view?acc_num=osu1486463321625038.

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16

GUIR, FREDERIC. "Contribution a la synthese totale du taxol." Paris 11, 1990. http://www.theses.fr/1990PA112038.

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Ce travail se divise en deux parties: la premiere partie s'attache a l'etude de la formation des cycles b et c du taxane sur un modele ainsi que de la stereochimie de la jonction de ces cycles b/c par voie photochimique. Le produit final obtenu: la 14,14-dimethyl-tricyclo 9. 2. 1. 0#3#,#8 tetradecanedione-2,10 possede la jonction de cycle trans 3,8 inverse de celle du taxane. La deuxieme partie decrit la synthese de la dihydroxy-2,12 trimethyl-4,8,11 tricyclo 5. 3. 1. 1#4#,#1#1 dodecene-8 one-5 qui par retroaldolisation conduirait a la formation du systeme bicyclo 5. 3. 1 undecene a/b du taxol

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17

Delaloge, Francette. "Contribution à la synthèse totale du taxol." Palaiseau, Ecole polytechnique, 1995. http://www.theses.fr/1995EPXX0023.

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Le taxol, composé extrait de diverses espèces d'ifs, a été découvert dans les années 1970. Ce diterpène est un agent anticancéreux puissant au mode d'action original. Au cours de ce travail, nous nous sommes intéressés a la synthèse totale du taxol, selon une stratégie convergente basée sur la fermeture tardive du cycle b en position c1-c2. Après avoir étudié la fermeture du cycle a 8 chainons, par couplage pinacolique, sur un composé modèle, nous avons envisagé la synthèse de précurseurs de la cyclisation par utilisation de dérivés stannyles. Les résultats encourageants obtenus permettent d'e

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18

MULLER, BENOIT. "Contribution a la synthese totale du taxol." Palaiseau, Ecole polytechnique, 1996. http://www.theses.fr/1996EPXX0018.

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Le taxol est un diterpene de la famille des taxanes et possede une activite anticancereuse importante avec un mode d'action original. L'objectif de ce travail de these a ete de developper une approche de synthese totale du taxol, fondee sur une strategie convergente de type acabc faisant intervenir une fermeture tardive du cycle b en position c9-c10. Dans une premiere partie, toute une gamme de synthons correspondant au cycle a a ete synthetisee de facon originale en utilisant de nombreux aspects de la chimie de l'etain. A partir des differents synthons ainsi elabores, une serie d'etudes explo

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19

Pryde, David C. "A tandem radical macrocyclisation transannulation approach to taxanes." Thesis, University of Nottingham, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.284142.

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20

Aouzal, Rémi. "Vers la synthèse du tricycle ABC du Taxol." Phd thesis, Ecole Polytechnique X, 2010. http://pastel.archives-ouvertes.fr/pastel-00516141.

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Au cours de cette thèse, nous avons cherché à appliquer la réaction de métathèse des oléfines pour synthétiser le tricycle ABC du taxol, une molécule naturelle issue de l'if de l'ouest dans les années 1960. Nous avons pour cela étudié deux rétrosynthèses: - la première s'appuie sur la fermeture du cycle B à huit chaînons par une métathèse relais cyclisante. - la seconde repose sur une métathèse tandem ène-yne-ène permettant la formation en une seule étape des cycles A et B.

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21

Schiltz, Stéphanie. "Approche de synthèse du tricycle ABC du taxol." Phd thesis, Ecole Polytechnique X, 2005. http://pastel.archives-ouvertes.fr/pastel-00001803.

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Le taxol est un composé découvert en 1965 à partir d'un extrait d'if du Pacifique (Taxus Brevifolia Nutt.). Son mode d'action original et inconnu au moment de sa découverte a fait de cette molécule une référence en matière de traitement anti-cancéreux. La présence de nombreuses fonctionnalités oxygénées, le nombre élevé de centres asymétriques et surtout sa structure tétracyclique comportant de plus un cycle à huit chaînons ont suscité l'intérêt des chercheurs depuis sa publication. Découverte dans les années 1970, la réaction de métathèse cyclisante des oléfines est un outil synthétique extrê

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22

Ma, Cong. "Vers la synthèse du tricycle ABC du Taxol." Phd thesis, Ecole Polytechnique X, 2008. http://pastel.archives-ouvertes.fr/pastel-00004596.

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23

Metaferia, Belhu B. "Synthesis of Taxol™ Analogs as Conformational Probes." Diss., Virginia Tech, 2002. http://hdl.handle.net/10919/28428.

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Taxol™, isolated from the bark of Taxus brevifolia in the late 1960s, and the semisynthetic analog Taxotere™ have proven clinical importance for the treatment of ovarian and breast cancer. Taxol™ exerts its biological effect by binding to polymerized tubulin and stabilizing the resulting microtubules. Studies aimed at understanding the biologically active conformation of taxol and its binding environment on β-tubulin are described. This knowledge is important because it could lead to the design of structurally less complicated drugs with better efficacy and better bioavailability. Moreover

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24

Kreilein, Matthew M. "Progress toward the total synthesis of paclitaxel (taxol)." The Ohio State University, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=osu1117063322.

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25

Zeng, Qingbei. "Studies toward the total synthesis of Taxol®/." The Ohio State University, 1999. http://rave.ohiolink.edu/etdc/view?acc_num=osu1488190595940418.

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26

Tierney, Jason P. "Stereoselective synthesis of C-glycosidic oxetanes." Thesis, Imperial College London, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.309528.

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27

FERREIRA, JEAN-PAUL. "Synthese convergente du squelette taxoide tetramethyltricyclo (9. 3. 1. 0. 3,8) pentadecane (doctorat : pharmacochimie)." Paris 11, 1998. http://www.theses.fr/1998PA114809.

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28

Targa, Benjamin. "Dialogue entre SEPT9_i1 et polyglutamylation de la tubuline : coopération dans la chimiorésistance aux taxanes et dans la localisation microtubulaire des filaments de septines." Thesis, Université Paris-Saclay (ComUE), 2015. http://www.theses.fr/2015SACLS183.

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L’émergence de phénomènes de résistance au paclitaxel (Taxol®), un agent stabilisateur de microtubules (MTs), est un obstacle majeur au succès de cette molécule dans les chimiothérapies anticancéreuses et limite son utilisation. Au laboratoire, un nouveau mécanisme de résistance au Taxol® a été mis en évidence dans les cellules tumorales mammaires MDA-MB 231. Il est basé sur une restauration de la dynamique microtubulaire et implique i) deux modifications post-traductionnelles de la tubuline (MPTs), la détyrosination/retyrosination et la polyglutamylation et ii) la surexpression et la relocali

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29

Vandana, Vishnu. "Separation of taxol and related taxanes using supercritical fluids." Diss., Georgia Institute of Technology, 1995. http://hdl.handle.net/1853/10078.

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30

Wilkes, Antonia. "Towards the synthesis of the ABC tricycle of Taxol." Thesis, University of Glasgow, 2015. http://theses.gla.ac.uk/5885/.

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Taxol is one of the world’s most successful drugs used in the treatment of cancers. Isolated from the bark of the Pacific yew tree (Taxus brevifolia), it is a molecule of great interest within organic chemistry; with six total syntheses and a number of synthetic works having been published since its discovery. A semi-convergent synthesis of an intermediate in Holton’s synthesis was planned. The overall synthetic plan is shown below. The A ring would be installed by an intramolecular pinacol condensation. The BC bicycle would be closed by ring-closing metathesis at C10-C11. The ketone at C12 wo

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31

Mangatal, Lydie. "Dérivés antitumoraux du taxol : hémisynthèse et relations structure-activité." Paris 11, 1989. http://www.theses.fr/1989PA112093.

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Le taxol, diterpène de type taxane, extrait difficilement des écorces de tronc de l'If (Taxus baccata L. ), est un "poison du fuseau mitotique" possédant un mode d'action unique sur la tubuline. Son hémisynthèse, ainsi que celle d'analogues structuraux a été entreprise à partir de la désacétyl-10baccatine III isolée des feuilles de l'If. L'hémisynthèse a été effectuée selon deux approches différentes. Une des voies fait intervenir une réaction d'hydroxyamination de Sharpless dont la sélectivité a été étudiée. L'activité biologique des analogues structuraux, ainsi que des intermédiaires d'hémis

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32

Baloglu, Erkan Jr. "A New Synthesis of Taxol®, from Baccatin III." Thesis, Virginia Tech, 1998. http://hdl.handle.net/10919/36930.

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Taxol®, an important anticancer drug, was first isolated in extremely low yield from the bark of the western yew, Taxus brevifolia. The clinical utility of Taxol has prompted a tremendous effort to obtain this complex molecule synthetically. Due to the chemical complexity of Taxol, its commercial production by total synthesis is not likely to be economical. Another natural product, 10-deacetyl baccatin III, is readily available in higher yield. Several methods have been reported for the synthesis of Taxol by coupling baccatin III and the N-benzoyl-β-phenylisoserine side chain. A new method

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33

Tsui, Hon-Chung. "Studies on the synthesis of Kaurane Diterpenoids and Taxol /." The Ohio State University, 1998. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487951214937412.

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34

Froidevaux-Klipfel, Laurence. "Implication des septines recrutées sur les microtubules tyrosinés et polyglutamylés dans la résistance au taxol de cellules cancéreuses mammaires MDA-MB 231." Thesis, Paris 11, 2011. http://www.theses.fr/2011PA114850/document.

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Le cancer du sein est une cause importante de mortalité féminine en France et l’émergence de chimiorésistance, en particulier avec les taxanes, dont le paclitaxel (Taxol®), est une limite importante à l’emploi de ces molécules. Comme de nombreux anticancéreux, les taxanes ciblent les microtubules (MTs), des polymères de tubuline intervenant dans de nombreuses fonctions cellulaires. Ces derniers alternent entre des phases de croissance et de désassemblage, leur conférant ainsi un caractère dynamique. En se liant à la beta-tubuline, le Taxol stabilise les MTs et bloque la mitose, conduisant la c

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35

Houldsworth, Stephen J. "A radical macrocyclisation-transannulation approach to the naturally occurring taxanes." Thesis, University of Nottingham, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.294250.

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36

Payne, Lloyd James. "Synthetic studies towards selected natural products." Thesis, University of Sussex, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.388677.

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37

Johnston, Jeffrey N. "Synthetic studies directed toward polycavernoside A and Taxol(RTM) (paclitaxel) /." The Ohio State University, 1997. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487946103569429.

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38

MARTEL, JEAN-PHILIPPE. "Etude de nouvelles approches de la synthese total du taxol." Université Louis Pasteur (Strasbourg) (1971-2008), 1994. http://www.theses.fr/1994STR13164.

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Le taxol est une molecule d'un grand interet pharmacologique. Nous nous sommes interesses a la synthese totale de ce produit naturel, en developpant successivement deux strategies, dans le but notamment de construire le cycle b a huit atomes de carbone. La premiere strategie est basee sur une transposition de type wagner-meerwein d'un systeme bicyclique 7/7 pour conduire a un systeme bicyclique 6/8 correspondant aux cycles a et b du taxol. Plusieurs precurseurs potentiels pour cette transposition ont ete synthetises puis testes. Cette approche n'a pas donne les resultats escomptes et n'a pas e

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39

Aarão, Serra Antonio. "Approches synthétiques de terpènes : (+)-acide hirsutique C, (+)-brasilénol et (-)-taxol." Grenoble 1, 1987. http://www.theses.fr/1987GRE10142.

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Dans un premier temps, la synthese de l'acide hirsutique c naturel a ete realisee, en dix-huit etapes, avec un rendement global d'un pourcent. Ensuite, la premiere synthese enantioselective du brasilenol naturel a ete effectuee avec un tres haut rendement global (trente et un pourcent) en sept etapes a partir d'un produit facilement accessible, la (r)-(moins)-criptone. Enfin, pour la premiere fois, la chaine laterale du taxol optiquement pure a ete preparee en sept etapes a partir du phenylacetylene avec un rendement global de vingt trois pourcent. Cette chaine a servi de produit de depart pou

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40

Letort, Aurelien. "Ring-closing metathesis cascade toward a formal synthesis of taxol." Thesis, University of Glasgow, 2015. http://theses.gla.ac.uk/6677/.

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TaxolTM and its derivatives are the largest selling anticancer drugs of all time. Numerous synthetic works and total syntheses have been published since its discovery, but to date no high yielding synthesis with less than 37 steps has been achieved. In this thesis is presented our synthetic efforts toward such a robust and efficient synthesis of Taxol. The optimisation of the Shapiro coupling fragments syntheses were investigated to enhance the robustness of our strategy. Then the C7-deoxy model ABC tricycle ring-system of Taxol, which lacks the oxygenated substituent at C7, has been efficient

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41

Aarão, Serra Antonio. "Approches synthétiques de terpenes (+)-acide hirsutique C, (+)-brasilenol et (-)-taxol /." Grenoble 2 : ANRT, 1987. http://catalogue.bnf.fr/ark:/12148/cb37602017k.

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42

Chavan, S. P. "Synthetic studies towards taxol and development of synthetically useful methodology." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 2006. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/2790.

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43

Waibel, Thomas. "Transcriptional regulation of taxol™ biosynthesis in Taxus cuspidate procambium cells." Thesis, University of Edinburgh, 2011. http://hdl.handle.net/1842/5681.

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This thesis presents an investigation into the transcriptional regulation of TaxolTM biosynthsis in Taxus cuspidata cell suspension cultures. The potent anticancer drug TaxolTM has been shown to be successful in the treatment of breast, lung and ovarian cancer and the acquired immunodeficiency syndrome (AIDS) related Kaposi’s sarcoma. Produced by all species of yew, TaxolTM belongs to the class of taxane diterpenoids and is of huge pharmaceutical importance. The plant material utilised in this thesis is a cell suspension culture initiated from isolated procambium cells of T. cuspidata. The lat

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44

Koo, Ki Chul. "Studies towards the total synthesis of 1-deoxy-8-demethyl taxol." Tallahassee, Florida : Florida State University, 2009. http://etd.lib.fsu.edu/theses/available/etd-08222009-032151/.

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Thesis (Ph. D.)--Florida State University, 2009.<br>Advisor: Robert A. Holton, Florida State University, College of Arts and Sciences, Dept. of Chemistry and Biochemistry. Title and description from dissertation home page (viewed on April 27, 2010). Document formatted into pages; contains xvii, 362 pages. Includes bibliographical references.

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45

Parra, Stephanie Marie. "A double Diels-Alder strategy towards the synthesis of Taxol analogues." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp05/NQ66181.pdf.

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46

Quinn, Jennifer E. "BRCA1 mediated G2/M cell cycle arrest in response to taxol." Thesis, Queen's University Belfast, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.326034.

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47

Bourgeois, Damien. "Approche de synthèse du taxol : fermeture du cycle B par métathèse." Palaiseau, Ecole polytechnique, 2000. http://www.theses.fr/2000EPXX0032.

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Ce travail s'inscrit dans un projet du laboratoire dont l'objectif est la synthèse du taxol, un agent antitumoral naturel. Cette molécule présente un intérêt notable en raison de son squelette particulier et de la présence de nombreuses fonctions oxygénées. Une approche convergente reposant sur la fermeture du cycle b central a 8 chainons a été étudiée. A cet effet, un précurseur du cycle c a été synthétise, et son couplage par réaction de shapiro avec un aldéhyde précurseur du cycle a été étudié. La fermeture des divers séco-taxanes ainsi obtenus par réaction de métathèse a été inefficace. En

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48

Castro, Carmona Javier Servando. "MOLECULAR AND BIOMOLECULAR-BASED NANOMATERIALS: TUBULIN AND TAXOL AS MOLECULAR CONSTITUENTS." Diss., The University of Arizona, 2009. http://hdl.handle.net/10150/195413.

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The new field of protein-based nano-technology takes advantage of the complex interactions between proteins to form unique structures with properties that cannot be achieved with traditional components. Microtubules (MTs), self assembled proteinaceous hollow filaments, offer promise in the development of MT-based nano-systems. The compelling need for the controlled assembly of 3D MT arrays is the fundamental motivation for the first part of this research. We report on the morphology of MTs grown in a crowded environment in the form of high viscosity fluids containing agarose and a novel proces

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49

Thomson, Nicholas M. "Tandem radical macrocyclisation-transannulation reactions in polycycle constructions." Thesis, University of Nottingham, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.387860.

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50

Spencer, William John. "Phorbol ester-mediated NF-kappa-B transactivation is selectively inhibited by taxol." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape10/PQDD_0007/MQ44286.pdf.

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