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Journal articles on the topic 'Tc cells'

Author: Grafiati

Published: 10 December 2022

Last updated: 31 July 2025

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1

El Khawanky, Nadia, Amy Hughes, Wenbo Yu, et al. "Azacytidine Sensitizes AML Cells for Effective Elimination By CD123 CAR T-Cells." Blood 134, Supplement_1 (2019): 3904. http://dx.doi.org/10.1182/blood-2019-124684.

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Chimeric antigen receptor T-cells (CAR Tc) have yielded impressive remission rates in treatment-refractory B-cell malignancies (B-ALL and B-lymphomas) by targeting CD19, resulting in the first FDA approved CAR Tc therapies, Kymriah and Yescarta. However, the translation of these results for other cancer entities remains a challenge. Pre-clinical studies using second-generation CAR Tc against the interleukin-3 receptor alpha chain (CD123) engendered strong anti-leukemic activity. CD123 CAR Tc clinical studies resulted in transient responses, or complete remission but at the expense of on-target

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2

Kos, F. J., and E. G. Engleman. "Requirement for natural killer cells in the induction of cytotoxic T cells." Journal of Immunology 155, no. 2 (1995): 578–84. http://dx.doi.org/10.4049/jimmunol.155.2.578.

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Abstract Cell-mediated immunity involves the participation of both regulatory and cytotoxic cells. The conversion of precursors to effector CD8+ cytotoxic T (Tc) cells requires cell-cell collaboration in which CD4+ T cells are traditionally viewed as helper cells. An in vitro system was used here to demonstrate that the generation of human alloantigen-specific CD8+ Tc cells requires the participation of CD3-CD16+CD56+ NK cells but not CD4+ T helper cells. Depletion of NK cells from responders abolished the induction of alloantigen-specific Tc cells in mixed lymphocyte cultures (MLC). Purified

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3

Šímová, Jana, J. Bubeník, J. Bieblová, M. Indrová, and T. Jandlová. "Immunotherapeutic Efficacy of Vaccines Generated by Fusion of Dendritic Cells and HPV16-Associated Tumour Cells." Folia Biologica 51, no. 1 (2005): 19–24. https://doi.org/10.14712/fb2005051010019.

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Utilization of vaccines generated by fusion of dendritic cells and tumour cells is a promising approach to tumour immunotherapy. We have examined the therapeutic efficacy of vaccines generated by fusion of HPV16-associated tumour cells TC-1 with syngeneic and allogeneic dendritic cells. Locally administered hybrid cells generated by fusion of MHC class I+ TC-1 cells and syngeneic DC inhibited the growth of MHC class I+ TC-1 tumours, but not the growth of MHC class I- TC-1/A9-derived tumours. The growth of TC-1 tumours was also inhibited by hybrids generated by fusion of TC-1 cells and allogene

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4

Huang, Nick, Brandon Wyman, Emma Cravo, et al. "Rab4A inactivation in T cells blocks mTOR activation, pro-inflammatory lineage development, and disease pathogenesis in lupus-prone mice." Journal of Immunology 202, no. 1_Supplement (2019): 115.6. http://dx.doi.org/10.4049/jimmunol.202.supp.115.6.

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Abstract Introduction Expression of Rab4A is increased in T cells of patients and mice with SLE. Overexpression of Rab4A forms a positive feedback loop with mTOR that can be blocked with therapeutic efficacy in SLE. To determine the impact of this gene on disease development, the triple-congenic lupus-prone Sle1.2.3 mouse strain (TC) have been backcrossed with C57Bl/6 wild-type (WT) mice that carry floxed Rab4AQ72L (TC-FL) alleles or lack Rab4A in T cells (TC-KO). Methods Proteinuria was assessed by the Bradford assay. Splenocytes were examined by flow cytometry. Autoantibody production was me

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5

Destexhe, A., T. Bal, D. A. McCormick, and T. J. Sejnowski. "Ionic mechanisms underlying synchronized oscillations and propagating waves in a model of ferret thalamic slices." Journal of Neurophysiology 76, no. 3 (1996): 2049–70. http://dx.doi.org/10.1152/jn.1996.76.3.2049.

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1. A network model of thalamocortical (TC) and thalamic reticular (RE) neurons was developed based on electrophysiological measurements in ferret thalamic slices. Single-compartment TC and RE cells included voltage- and calcium-sensitive currents described by Hodgkin-Huxley type of kinetics. Synaptic currents were modeled by kinetic models of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), gamma-aminobutyric acid-A (GABAA) and GABAB receptors. 2. The model reproduced successfully the characteristics of spindle and slow bicuculline-induced oscillations observed in vitro. The ch

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6

Inoue, Tsuyoshi, and Keiji Imoto. "Feedforward Inhibitory Connections From Multiple Thalamic Cells to Multiple Regular-Spiking Cells in Layer 4 of the Somatosensory Cortex." Journal of Neurophysiology 96, no. 4 (2006): 1746–54. http://dx.doi.org/10.1152/jn.00301.2006.

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Thalamocortical (TC) cells in the ventrobasal thalamus make direct excitatory connections with regular-spiking (RS) cells in layer 4 of the somatosensory cortex, but also make disynaptic feedforward inhibitory connections with the RS cells by layer 4 fast-spiking (FS) cells. In this study, we investigated connection rules of the feedforward inhibitory circuit from multiple TC cells to multiple RS cells, at the level of synaptic potentials. Using thalamocortical brain slices of young mice (postnatal days 12–16), we made simultaneous patch-clamp recordings from three adjacent cortical cells (two

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7

Reuter, Audrey, Chloé Virolle, Kelly Goldlust, Annick Berne-Dedieu, Sophie Nolivos, and Christian Lesterlin. "Direct visualisation of drug-efflux in live Escherichia coli cells." FEMS Microbiology Reviews 44, no. 6 (2020): 782–92. http://dx.doi.org/10.1093/femsre/fuaa031.

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ABSTRACT Drug-efflux by pump proteins is one of the major mechanisms of antibiotic resistance in bacteria. Here, we use quantitative fluorescence microscopy to investigate the real-time dynamics of drug accumulation and efflux in live E. coli cells. We visualize simultaneously the intrinsically fluorescent protein-synthesis inhibitor tetracycline (Tc) and the fluorescently labelled Tc-specific efflux pump, TetA. We show that Tc penetrates the cells within minutes and accumulates to stable intracellular concentration after ∼20 min. The final level of drug accumulation reflects the balance betwe

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8

Schwartz, L. B., A. M. Irani, K. Roller, M. C. Castells, and N. M. Schechter. "Quantitation of histamine, tryptase, and chymase in dispersed human T and TC mast cells." Journal of Immunology 138, no. 8 (1987): 2611–15. http://dx.doi.org/10.4049/jimmunol.138.8.2611.

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Abstract Levels of histamine, chymase, and tryptase were assessed in preparations of dispersed human TC (tryptase+, chymase+) mast cells obtained from foreskin and of dispersed human T (tryptase+, chymase-) mast cells obtained from lung. Consistent with previous immunohistochemical results, extracts of T mast cells, the predominant mast cell type in lung (93% T and 7% TC mast cells), were deficient in human chymase (less than 0.3 microgram and 0.04 U/10(6) mast cells) but not tryptase (10.8 micrograms and 0.3 U/10(6) mast cells) by corresponding immunologic and enzymatic (suc-L-ala-ala-pro-phe

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9

Namour, Farès, Jean-Luc Olivier, Idrissia Abdelmouttaleb, et al. "Transcobalamin codon 259 polymorphism in HT-29 and Caco-2 cells and in Caucasians: relation to transcobalamin and homocysteine concentration in blood." Blood 97, no. 4 (2001): 1092–98. http://dx.doi.org/10.1182/blood.v97.4.1092.

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Abstract Transcobalamin (TC) is the plasma transporter that delivers vitamin B12 to cells. We have already reported that HT-29 and Caco-2 cells secrete different TC variants. HT-29 secretes 2 TC isoproteins (codon 259-Pro/Arg [259-P/R]), exhibiting unequal concentrations (TC 259-P &gt; TC 259-R), and Caco-2 cells only secrete the phenotype 259-R. We investigated the relation between phenotypic and genetic TC polymorphism in HT-29 cells transfected with Caco-2 TC complementary DNA and in 159 healthy Caucasians. We found that codon 259-R is buried and, thus, the genetic polymorphism provides

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10

Carmel, R., SM Neely, and RB Jr Francis. "Human umbilical vein endothelial cells secrete transcobalamin II." Blood 75, no. 1 (1990): 251–54. http://dx.doi.org/10.1182/blood.v75.1.251.251.

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Abstract Transcobalamin II (TC II) is essential for cellular uptake of cobalamin. However, the origin of this transport protein is controversial and many organ sources have been suggested. We studied human umbilical vein endothelial cells cultured in vitro. The cells contained TC II (2.3 pmol/10(8) cells) and released progressively increasing amounts of the protein into the surrounding medium during the 3-day incubation period. This release exceeded the starting intracellular content of TC II. In contrast, endothelial cells did not contain or elaborate R binder, the other major circulating bin

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Carmel, R., SM Neely, and RB Jr Francis. "Human umbilical vein endothelial cells secrete transcobalamin II." Blood 75, no. 1 (1990): 251–54. http://dx.doi.org/10.1182/blood.v75.1.251.bloodjournal751251.

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Transcobalamin II (TC II) is essential for cellular uptake of cobalamin. However, the origin of this transport protein is controversial and many organ sources have been suggested. We studied human umbilical vein endothelial cells cultured in vitro. The cells contained TC II (2.3 pmol/10(8) cells) and released progressively increasing amounts of the protein into the surrounding medium during the 3-day incubation period. This release exceeded the starting intracellular content of TC II. In contrast, endothelial cells did not contain or elaborate R binder, the other major circulating binding prot

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12

Zheng, Ying Yi. "Marginal zone B cells contribute to autoimmunity in the NZM2410 lupus prone mouse model. (159.13)." Journal of Immunology 188, no. 1_Supplement (2012): 159.13. http://dx.doi.org/10.4049/jimmunol.188.supp.159.13.

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Abstract Lupus is an autoimmune disease in which the affected individual generates antibodies (Abs) against nuclear antigens such as DNA. Our NZM2410-derived triple congenic (TC) model of lupus expresses 3 previously characterized lupus susceptibility loci. We have previously shown that the breach of follicular exclusion of TC MZB cells is associated with disease progression. The production of nuclear autoAbs occurred in tandem with a large influx of TC MZB cells in the follicles. We also found an expansion of MZB cells in TC mice as compared to non-autoimmune B6 mice that occurs prior to the

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13

Kim, Sung Man, Eun Ju Lee, Hye Sook Jung та ін. "Co-Culture of α TC-6 Cells and β TC-1 Cells: Morphology and Function". Endocrinology and Metabolism 30, № 1 (2015): 92. http://dx.doi.org/10.3803/enm.2015.30.1.92.

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14

Jaime-Sanchez, Paula, Iratxe Uranga-Murillo, Nacho Aguilo, et al. "Cell death induced by cytotoxic CD8+T cells is immunogenic and primes caspase-3–dependent spread immunity against endogenous tumor antigens." Journal for ImmunoTherapy of Cancer 8, no. 1 (2020): e000528. http://dx.doi.org/10.1136/jitc-2020-000528.

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BackgroundElimination of cancer cells by some stimuli like chemotherapy and radiotherapy activates anticancer immunity after the generation of damage‐associated molecular patterns, a process recently named immunogenic cell death (ICD). Despite the recent advances in cancer immunotherapy, very little is known about the immunological consequences of cell death activated by cytotoxic CD8+T (Tc) cells on cancer cells, that is, if Tc cells induce ICD on cancer cells and the molecular mechanisms involved.MethodsICD induced by Tc cells on EL4 cells was analyzed in tumor by vaccinating mice with EL4 c

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15

Vackova, Julie, Ingrid Polakova, Shweta Dilip Johari, and Michal Smahel. "CD80 Expression on Tumor Cells Alters Tumor Microenvironment and Efficacy of Cancer Immunotherapy by CTLA-4 Blockade." Cancers 13, no. 8 (2021): 1935. http://dx.doi.org/10.3390/cancers13081935.

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Cluster of differentiation (CD) 80 is mainly expressed in immune cells but can also be found in several types of cancer cells. This molecule may either activate or inhibit immune reactions. Here, we determined the immunosuppressive role of CD80 in the tumor microenvironment by CRISPR/Cas9-mediated deactivation of the corresponding gene in the mouse oncogenic TC-1 cell line. The tumor cells with deactivated CD80 (TC-1/dCD80-1) were more immunogenic than parental cells and induced tumors that gained sensitivity to cytotoxic T-lymphocyte antigen 4 (CTLA-4) blockade, as compared with the TC-1 cell

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Visciano, Carla, Nella Prevete, Federica Liotti, and Gianni Marone. "Tumor-Associated Mast Cells in Thyroid Cancer." International Journal of Endocrinology 2015 (2015): 1–8. http://dx.doi.org/10.1155/2015/705169.

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There is compelling evidence that the tumor microenvironment plays a major role in mediating aggressive features of cancer cells, including invasive capacity and resistance to conventional and novel therapies. Among the different cell populations that infiltrate cancer stroma, mast cells (MCs) can influence several aspects of tumor biology, including tumor development and progression, angiogenesis, lymphangiogenesis, and tissue remodelling. Thyroid cancer (TC), the most frequent neoplasia of the endocrine system, is characterized by a MC infiltrate, whose density correlates with extrathyroidal

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17

Kos, F. J., and A. Müllbacher. "IL-2-independent activity of IL-7 in the generation of secondary antigen-specific cytotoxic T cell responses in vitro." Journal of Immunology 150, no. 2 (1993): 387–93. http://dx.doi.org/10.4049/jimmunol.150.2.387.

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Abstract Purified CD8+ splenocytes from influenza virus strain A/WSN/33 (H1N1)-immune BALB/c (H-2d) mice responded to a synthetic peptide, synthetic influenza nucleoprotein peptide 147-158 R-, with a sequence (147-158 R156-) derived from influenza A virus nucleoprotein with high affinity for Kd class I MHC molecules, with the generation of effector cytotoxic T (Tc) cells specific for influenza A virus-infected target cells in vitro. The process of the conversion of synthetic influenza nucleoprotein peptide 147-158R- -Kd-responding memory Tc into effector Tc cells requires Ag in the form of pep

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18

Jimenez, David Gomez, Aastha Sobti, David Askmyr, et al. "Tonsillar Cancer with High CD8+ T-Cell Infiltration Features Increased Levels of Dendritic Cells and Transcriptional Regulation Associated with an Inflamed Tumor Microenvironment." Cancers 13, no. 21 (2021): 5341. http://dx.doi.org/10.3390/cancers13215341.

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Human papillomavirus (HPV) is the main causal agent of tonsillar cancer (TC) and HPV+ TC has a favorable prognosis compared to HPV− disease. In this study, we examined aspects of the tumor microenvironment of TC, focusing on T-cells, dendritic cells (DC), and macrophages. Fresh biopsies of TC and the contralateral healthy tonsil (HT) were obtained from 20 patients, analyzed by multiparameter flow cytometry, and assessed against a detailed HPV-status. Additionally, RNA-sequencing data from 38 TC samples available in the public database, The Cancer Genome Atlas (TCGA), were explored, focusing on

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Pellegrini, Maria-Simonetta Faussone, and Laurenţiu M. Popescu. "Telocytes." BioMolecular Concepts 2, no. 6 (2011): 481–89. http://dx.doi.org/10.1515/bmc.2011.039.

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AbstractHere, we review the history, morphology, immunohistochemical phenotype, and presumptive roles of a new type of interstitial tissue cells, formerly called interstitial Cajal-like cells (ICLC) and by 2010 named ‘telocytes’ (TC). Many different techniques have been used to characterize TC and provide their unequivocal identification: (i) in vitro, cultures and isolated cells; (ii) in situ, fixed specimens examined by light and fluorescence microscopy, transmission (TEM) and scanning electron microscopy, and electron tomography. TEM allowed sure identification and characterization of the m

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Mueller, Antonia MS, Holbrook E. Kohrt, Sumana Shashidhar, et al. "Graft T Cells Retard Stem Cell Derived Lymphoid Organ Reconstitution and Immune Function After Allogeneic Transplantation,." Blood 118, no. 21 (2011): 4030. http://dx.doi.org/10.1182/blood.v118.21.4030.4030.

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Abstract Abstract 4030 Impaired immune function is a major cause of morbidity and mortality after allogeneic hematopoietic cell transplantation (HCT). Adoptively transferred donor T cells (TC) mediate graft-versus-host disease (GVHD), and make the use of pharmacological immunosuppression necessary, yet are believed to protect against infections post-HCT (pTX). In an MHC-matched, minor antigen mismatched mouse model, we studied the impact of allogeneic doTC on GVH-related damage of lymphoid organs, their recovery and immune function pTX. Lethally irradiated BALB.B mice received purified hematop

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Young, Ryan M., Avital Polsky, and Yosef Refaeli. "TC-PTP is required for the maintenance of MYC-driven B-cell lymphomas." Blood 114, no. 24 (2009): 5016–23. http://dx.doi.org/10.1182/blood-2008-12-196709.

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Abstract We sought to determine the contributions of protein tyrosine phosphatases (PTPs) to the pathogenesis of B-cell lymphomas. We found that T-cell PTP (TC-PTP) was overexpressed in transformed B cells. We hypothesized that TC-PTP may be a tumor-promoting gene that is regulated by MYC overexpression in B cells. Knockdown of TC-PTP in murine tumors resulted in decreased cell viability in vitro because of an arrest in the G1 phase of the cell cycle. Furthermore, cells with reduced TC-PTP expression were unable to either engraft or expand in vivo. Taken together, these data indicate that TC-P

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Pilic, Johannes, Furkan E. Oflaz, Benjamin Gottschalk, Yusuf C. Erdogan, Wolfgang F. Graier, and Roland Malli. "Visualizing VDAC1 in live cells using a tetracysteine tag." PLOS ONE 19, no. 10 (2024): e0311107. http://dx.doi.org/10.1371/journal.pone.0311107.

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The voltage-dependent anion channel 1 (VDAC1) is a crucial gatekeeper in the outer mitochondrial membrane, controlling metabolic and energy homeostasis. The available methodological approaches fell short of accurate visualization of VDAC1 in living cells. To permit precise VDAC1 imaging, we utilized the tetracysteine (TC)-tag and visualized VDAC1 dynamics in living cells. TC-tagged VDAC1 had a cluster-like distribution on mitochondria. The labeling of TC-tagged VDAC1 was validated with immunofluorescence. The majority of VDAC1-TC-clusters were localized at endoplasmic reticulum (ER)-mitochondr

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Li, Fenglei, and Kaushik Choudhuri. "TCR-enriched microvesicles provide antigen-specific help for class-switched antibody production." Journal of Immunology 208, no. 1_Supplement (2022): 166.20. http://dx.doi.org/10.4049/jimmunol.208.supp.166.20.

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Abstract Extracellular vesicles have shown essential roles in various biological processes, mainly through mediating cell-cell communications by its surface and internal cargo. Recently it was found that activated T cells release TCR enriched microvesicles (Tc-MV) from immunological synapse, but the function of Tc-MV is still a mystery. By analyzing proteomics and miRNA profiles of Tc-MV derived from mouse OT-II CD4 T cells (OVA323–339 specific), we found Tc-MV are enriched with proteins related to T cell helper function, including TCRs, CD40L, CD28, ICOS, OX40 and LFA-1, and also contained B

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Song, ZX, RK Shadduck, DJ Jr Innes, A. Waheed, and PJ Quesenberry. "Hematopoietic factor production by a cell line (TC-1) derived from adherent murine marrow cells." Blood 66, no. 2 (1985): 273–81. http://dx.doi.org/10.1182/blood.v66.2.273.273.

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Abstract An adherent cell line, termed TC-1, has been isolated from long-term liquid culture of murine marrow cells by repeated exposure of the adherent cells to 0.1% trypsin. This is an alkaline phosphatase- positive cell line showing variable staining with acid phosphatase and alpha-naphthyl acetate esterase. On electron microscopy, the cells have moderate amounts of rough endoplasmic reticulum and variable numbers of polyribosomes. Some cells contain large clusters of laked glycogen particles. Intermediate junctions are present between some cells. Conditioned medium from this cell line prod

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Song, ZX, RK Shadduck, DJ Jr Innes, A. Waheed, and PJ Quesenberry. "Hematopoietic factor production by a cell line (TC-1) derived from adherent murine marrow cells." Blood 66, no. 2 (1985): 273–81. http://dx.doi.org/10.1182/blood.v66.2.273.bloodjournal662273.

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An adherent cell line, termed TC-1, has been isolated from long-term liquid culture of murine marrow cells by repeated exposure of the adherent cells to 0.1% trypsin. This is an alkaline phosphatase- positive cell line showing variable staining with acid phosphatase and alpha-naphthyl acetate esterase. On electron microscopy, the cells have moderate amounts of rough endoplasmic reticulum and variable numbers of polyribosomes. Some cells contain large clusters of laked glycogen particles. Intermediate junctions are present between some cells. Conditioned medium from this cell line produced from

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Denaro, Nerina, Rebecca Romanò, Salvatore Alfieri, et al. "The Tumor Microenvironment and the Estrogen Loop in Thyroid Cancer." Cancers 15, no. 9 (2023): 2458. http://dx.doi.org/10.3390/cancers15092458.

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Thyroid cancer (TC) cells employ multiple signaling pathways, such as PI3K/AKT/mTOR and RAS/Raf/MAPK, fostering cell proliferation, survival and metastasis. Through a complex interplay with immune cells, inflammatory mediators and stroma, TC cells support an immunosuppressive, inflamed, pro-carcinogenic TME. Moreover, the participation of estrogens in TC pathogenesis has previously been hypothesized, in view of the higher TC incidence observed among females. In this respect, the interactions between estrogens and the TME in TC could represent a relevant, unexplored area of research. We thereby

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Ai, Xiaojiang. "circ_0008792 Prevents Against the Deterioration of Thyroid Cancer Through Regulating IGFBP5." Science of Advanced Materials 15, no. 1 (2023): 97–103. http://dx.doi.org/10.1166/sam.2023.4418.

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To detect the expression of circ_0008792 in thyroid cancer (TC) tissues and cell lines, and to explore the regulatory effect of circ_0008792 on TC progression. Relative levels of circ_0008792 and IGFBP5 in TC and paracancerous tissues were detected by quantitative real-time polymerase chain reaction (qRT-PCR). The influences of circ_0008792 and IGFBP5 on pathology and prognosis of TC patients were analyzed. After intervening circ_0008792 level by transfection, changes in proliferative and migratory abilities of BHP5-16 and TPC cells were analyzed by cell counting kit-8 (CCK-8) and transwell as

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Yang, Fei, Jie Zhang, Zhijun Zhao, et al. "Artemisinin suppresses aerobic glycolysis in thyroid cancer cells by downregulating HIF-1a, which is increased by the XIST/miR-93/HIF-1a pathway." PLOS ONE 18, no. 4 (2023): e0284242. http://dx.doi.org/10.1371/journal.pone.0284242.

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The incidence of thyroid cancer (TC) continues to increase worldwide. Aerobic glycolysis, the prominent feature of glucose metabolism in cancer progression, is associated with TC. We first demonstrated that HIF-1a is highly expressed in TC tissues and is positively correlated with the level of XIST in the serum of patients with TC. Then, we proved that XIST regulates the expression of HIF-1a through the XIST/miR-93/HIF-1a pathway, thereby regulating the level of glycolysis in TC cells. Knockdown of XIST inhibits glycolysis, proliferation, the cell cycle and metastasis of TC cells. Finally, we

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Mueller, Antonia MS, Sumana Shashidhar, Janice Brown, and Judith A. Shizuru. "Adoptively Transferred Mature T Cells Exhibit Diminished Reactivity to Murine Cytomegalovirus Compared to Nascent Donor T Cells and Impair Functional Immune Recovery After Allogeneic Hematopoietic Cell Transplantation." Blood 116, no. 21 (2010): 3732. http://dx.doi.org/10.1182/blood.v116.21.3732.3732.

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Abstract Abstract 3732 Infections due to impaired immune function are a major cause of morbidity and mortality after allogeneic hematopoietic cell transplantation (HCT). Adoptively transferred donor (do) T cells (TC) are thought to provide protective immunity, as TC-depleted grafts are associated with increased viral infections post HCT (pTX). TC-replete grafts, however, require immunosuppression to prevent GVHD, and can damage lymphoid organs causing additional immune dysfunction. Using an MHC-matched, minor antigen (miAg) mismatched GVHD model, we compared immune responses to murine cytomega

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Koide, J., and E. G. Engleman. "Differences in surface phenotype and mechanism of action between alloantigen-specific CD8+ cytotoxic and suppressor T cell clones." Journal of Immunology 144, no. 1 (1990): 32–40. http://dx.doi.org/10.4049/jimmunol.144.1.32.

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Abstract We have previously demonstrated that fresh CD8+ T cells proliferate in response to autologous, alloantigen-primed CD4+ T cells, and differentiate into Ts cells, which inhibit the response of fresh T cells to the primary allogeneic stimulator cell but not irrelevant stimulators. Although such Ts do not have discernible cytolytic activity, like classical cytotoxic T cells (Tc) they express CD3 and CD8 on their surface and function in a class I MHC-restricted manner. Our study was an attempt to compare the surface phenotype and mechanism of action of Ts and Tc clones derived from the sam

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Sun, Caixia, Ping Wang, Tiantian Gao, and Jinfeng Chi. "CCL18 Knockdown Suppresses Cell Growth and Migration in Thyroid Cancer." Journal of Healthcare Engineering 2022 (January 25, 2022): 1–8. http://dx.doi.org/10.1155/2022/1548155.

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Background. Chemokine (C-C motif) ligand 18 (CCL18) is a chemokine that plays a key role in immune and inflammatory responses. In recent years, CCL18 participates in the development and progression of various cancers, but its expression and role in thyroid cancer (TC) remain unclear. Methods. RT-qPCR assay and Western blot assay were used to explore the expression level of CCL18 in TC tissues and cells. Cell proliferation was measured by MTT assay. Transwell assay was adopted to detect cell migration in TC cells. Dual luciferase reporter assay was performed to assess the relationship between C

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Liu, Di, Rukhsanda Aziz, Md Jahidul Islam Shohag, et al. "Assessment of Indicators in a Human Liver Cell Line HL-7702 for Tetracycline Toxicity in Farm Soil." Agronomy 12, no. 3 (2022): 730. http://dx.doi.org/10.3390/agronomy12030730.

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Tetracycline (TC) contamination has become hot research topic, but little attention has been paid to its ecotoxicological monitoring. The primary objective of this study is to investigate the impact of TC on human normal liver cells (HL-7702) and find indicators for monitoring their ecotoxicity. The cytotoxicity of TC, at concentrations ranging from 0 to 1000 μg L−1, was assessed on HL-7702 cells. The results showed that TC significantly inhibited the cell viability at a high concentration (1000 μg L−1). The TC at exposure levels ≥ 50–100 μg L−1 significantly increased the levels of extracellu

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Vannucchi, Maria Giuliana, and Chiara Traini. "Interstitial cells of Cajal and telocytes in the gut: twins, related or simply neighbor cells?" Biomolecular Concepts 7, no. 2 (2016): 93–102. http://dx.doi.org/10.1515/bmc-2015-0034.

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AbstractIn the interstitium of the connective tissue several types of cells occur. The fibroblasts, responsible for matrix formation, the mast cells, involved in local response to inflammatory stimuli, resident macrophages, plasma cells, lymphocytes, granulocytes and monocytes, all engaged in immunity responses. Recently, another type of interstitial cell, found in all organs so far examined, has been added to the previous ones, the telocytes (TC). In the gut, in addition to the cells listed above, there are also the interstitial cells of Cajal (ICC), a peculiar type of cell exclusively detect

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He, Mei Tong, Chan Hum Park, Yu Su Shin, Ji Hyun Kim, and Eun Ju Cho. "Carthamus tinctorius L. Seed and Taraxacum coreanum Attenuate Oxidative Stress Induced by Hydrogen Peroxide in SH-SY5Y Cells." Foods 12, no. 19 (2023): 3617. http://dx.doi.org/10.3390/foods12193617.

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Oxidative stress is closely associated with the pathology of neurodegenerative diseases. The seeds of Carthamus tinctorius L. (CTS) and Taraxacum coreanum (TC) are reported as herbal medicines for neuroprotection. This study investigated the protective effect of CTS, TC, and their combination against oxidative stress induced by H2O2 in SH-SY5Y cells. The CTS and TC combination dose-dependently increased DPPH and ·OH radical scavenging activities compared with non-combination. The combination showed a higher increased cell survival rate in H2O2-stimulated SH-SY5Y cells than CTS or TC. Moreover,

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Anether, Gabriele, Inge Tinhofer, Monika Senfter, and Richard Greil. "Tetrocarcin-A—induced ER stress mediates apoptosis in B-CLL cells via a Bcl-2—independent pathway." Blood 101, no. 11 (2003): 4561–68. http://dx.doi.org/10.1182/blood-2002-08-2501.

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Abstract Tetrocarcin-A (TC-A), an antibiotic agent isolated from actinomycetes, has recently been described to antagonize Bcl-2 functions, thereby sensitizing tumor cells to cell death signals under control of Bcl-2. In this study, we analyzed the direct proapoptotic effect of TC-A in the B-chronic lymphocytic leukemia (B-CLL) model. We focused on the signal cascade triggered by TC-A in B-CLL cells and identified activated mitochondrial as well as endoplasmatic reticulum (ER) stress signals. The expression levels of known effector molecules mediating mitochondrial signaling, such as Bax and Bi

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Hasan, Aisha, Annamalai Selvakumar, Bo Dupont, Michel Sadelain, Isabelle Riviere та Richard J. O’Reilly. "IL-15 Augments in-Vitro Expansion and Functional Activity of Antigen-Specific Effector Memory T-Cells (TEM) While Co-Expression of IL-15 and IL-15 Rα on Antigen Presenting Cells Also Promotes Expansion of Central Memory T-Cells (TCM)". Blood 112, № 11 (2008): 3541. http://dx.doi.org/10.1182/blood.v112.11.3541.3541.

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Abstract Adoptive immunotherapy with in-vitro expanded antigen-specific T cells (TC) is often hampered by the extended culture times required to generate sufficient numbers of antigen- specific TC and their limited persistence in-vivo. IL-2 predominantly supports the generation of short-lived effector memory (TEM) and effector (TE) CD8+ TC without expanding the CD62L+ and CCR7+ central memory T cells (TCM), which may persist for long periods in vivo. We examined the potential of IL-15 to foster growth of CMVpp65- specific TC as well as expansion of both TEM and TCM CD8+ TC. Accordingly, TC fro

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Lambrechts, Yentl, Asier Antoranz Martinez, Maxim De Schepper, et al. "Capturing age-related changes in the tumor microenvironment of luminal breast cancer using the multiplex immunohistochemistry technique, MILAN." Journal of Clinical Oncology 41, no. 16_suppl (2023): e15089-e15089. http://dx.doi.org/10.1200/jco.2023.41.16_suppl.e15089.

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e15089 Background: The ‘immune landscape’ of luminal breast tumors is poorly described to date. We applied the ‘multiple iterative labeling by antibody ‘neodeposition’ (MILAN) technique for in-depth characterization of the tumor microenvironment of luminal-like breast cancer (BC) in relation to age. Methods: Newly diagnosed patients with early luminal BC (grade 2/3, ER+, HER2-, tumor size ≥1,5 cm) were prospectively included in UH Leuven between March 2014 and November 2015 and divided into 3 distinct age categories (young: 35-45 yrs.; middle: 55-65 yrs.; old: ≥70 yrs.). 55 patients (young: n

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Mueller, Antonia MS, Mareike Florek, and Judith Shizuru. "Engraftment Failure After Non-Myeloablative Hematopoietic Stem Cell Transplantation: Donor CD4 Cells Interfere with Residual Host Cells and Can Trigger Rejection of the Graft." Blood 114, no. 22 (2009): 3528. http://dx.doi.org/10.1182/blood.v114.22.3528.3528.

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Abstract Abstract 3528 Poster Board III-465 In the last decade the field of allogeneic hematopoietic cell transplantation has made significant strides in the reduction of morbidity and mortality using non-myeloablative conditioning. However, with reduced conditioning intensity the risk of allograft rejection has increased due to the persistence of host cells that mediate host-vs-graft alloreactivity or that occupy niches in the host hematopoietic microenvironment. Here we studied hematopoietic reconstitution and chimerism after non-myeloablative total body irradiation (TBI: 4 Gy [sublethal]; 7

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Hammerich, Linda, Judit Svensson-Arvelund, Todd Covey, and Joshua Brody. "Ibrutinib, but not acalabrutinib, inhibits anti-lymphoma T cell and NK cell function." Journal of Immunology 202, no. 1_Supplement (2019): 136.19. http://dx.doi.org/10.4049/jimmunol.202.supp.136.19.

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Abstract Chronic Lymphocytic Leukemia (CLL) is the predominant hematologic malignancy in the U.S. BTK inhibitors (BTKi) demonstrate prolonged survival compared to standard chemotherapy, but they also show notable toxicity, including increased risk for infections. While BTKi have shown both immunosuppressive and -stimulatory effects, the overall effect on T cells (TC), including tumor-reactive TC, is not well understood. Because non-BTK TEC-family and homologous kinases have critical roles in immune cells, we tested whether differentially specific BTKi have differing immunomodulatory effects. W

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Ntranos, Achilles, Inna Grishkan, Dionne Robinson, et al. "Dissecting fingolimod’s action: a novel immunomodulatory effect of the unphosphorylated compound on cytotoxic T cell function (P5159)." Journal of Immunology 190, no. 1_Supplement (2013): 68.7. http://dx.doi.org/10.4049/jimmunol.190.supp.68.7.

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Abstract Fingolimod (FTY), a sphingosine-1-phosphate receptor modulator, is a multiple sclerosis (MS) therapeutic that upon phosphorylation traps CCR7+ T cells in lymph nodes (LN). CCR7- effector T cells are spared, thus allowing effective infection clearance. Nonetheless, FTY-treated patients are more susceptible to viral infections, indicating a cytotoxic T (Tc) cell defect. Yet, FTY’s effect on Tc cells remains unclear. To address this question, we utilized experimental autoimmune encephalomyelitis (EAE) and a murine influenza model. FTY ameliorated EAE by sequestering T cells, but also inh

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Qiu, Jiantai, Donia Alson, Ta-Hsien Lee, et al. "Effect of Multiple Vaccinations with Tumor Cell-Based Vaccine with Codon-Modified GM-CSF on Tumor Growth in a Mouse Model." Cancers 11, no. 3 (2019): 368. http://dx.doi.org/10.3390/cancers11030368.

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Ectopic expression of codon-modified granulocyte-macrophage colony-stimulating factor (cGM-CSF) in TC-1 cells (TC-1/cGM-CSF), a model cell line for human papillomavirus (HPV)-infected cervical cancer cells, increased the expression level of GM-CSF and improved the efficacy of tumor cell-based vaccines in a cervical cancer mouse model. The number of vaccine doses required to induce a long-term immune response in a cervical cancer mouse model is poorly understood. Here, we investigated one, three, and five doses of the irradiated TC-1/cGM-CSF vaccine to determine which dose was effective in indu

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Müllbacher, A., A. B. Hill, R. V. Blanden, W. B. Cowden, N. J. King, and R. T. Hla. "Alloreactive cytotoxic T cells recognize MHC class I antigen without peptide specificity." Journal of Immunology 147, no. 6 (1991): 1765–72. http://dx.doi.org/10.4049/jimmunol.147.6.1765.

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Abstract In this report, experiments are described to differentiate between three potential models of class I MHC allorecognition, namely 1) recognition of peptide-free MHC, 2) peptide-MHC-specific recognition, and 3) peptide-MHC-nonspecific recognition. Using a nucleoprotein peptide (NPP) with a sequence derived from influenza virus nucleoprotein with high affinity for Kd class I MHC molecules, it is shown that target cells rapidly become lysable by Kd-NPP self-restricted cytotoxic T (Tc) cells, and retain sufficient Kd-NPP complexes for at least 72 h. Kd-specific alloreactive Tc cells at the

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Isorna, Inmaculada, Miguel Ángel González-Moles, Miguel Muñoz, and Francisco Esteban. "Substance P and Neurokinin-1 Receptor System in Thyroid Cancer: Potential Targets for New Molecular Therapies." Journal of Clinical Medicine 12, no. 19 (2023): 6409. http://dx.doi.org/10.3390/jcm12196409.

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In recent years, numerous approaches have been developed to comprehend the molecular alterations underlying thyroid cancer (TC) oncogenesis and explore novel therapeutic strategies for TC. It is now well established that the neurokinin-1 receptor (NK-1R) is overexpressed in cancer cells and that NK-1R is essential for the viability of cancer cells. The binding of substance P (SP) to NK-1R in neoplastic cells plays a pivotal role in cancer progression by promoting neoplastic cell growth, protecting tumor cells from apoptosis, triggering invasion and metastasis through the enhanced migration of

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Nam, Ok Hyung, Jae-Hwan Kim, Sung Chul Choi, and Young Kim. "Time-Dependent Response of Human Deciduous Tooth-Derived Dental Pulp Cells Treated with TheraCal LC: Functional Analysis of Gene Interactions Compared to MTA." Journal of Clinical Medicine 9, no. 2 (2020): 531. http://dx.doi.org/10.3390/jcm9020531.

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Pulp capping material should facilitate hard tissue regeneration on the injured pulp tissue. TheraCal LC (TC) was recently developed. Although TC has shown reliable clinical outcomes after direct pulp capping, there are still remaining concerns regarding its detrimental effect on pulp cells. Therefore, this study aimed to identify the gene expression of human deciduous tooth-derived dental pulp cells exposed to TC compared to mineral trioxide aggregate (MTA). The cells were cultured and exposed to TC and MTA for 24 and 72 h. Next, total RNA was isolated. QuantSeq 3′ mRNA-sequencing was used to

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Schwarz, Sandra, Johanna Schmitz, Markus W. Löffler, et al. "T cells of colorectal cancer patients’ stimulated by neoantigenic and cryptic peptides better recognize autologous tumor cells." Journal for ImmunoTherapy of Cancer 10, no. 12 (2022): e005651. http://dx.doi.org/10.1136/jitc-2022-005651.

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BackgroundPatients with cancers that exhibit extraordinarily high somatic mutation numbers are ideal candidates for immunotherapy and enable identifying tumor-specific peptides through stimulation of tumor-reactive T cells (Tc).MethodsColorectal cancers (CRC) HROC113 and HROC285 were selected based on high TMB, microsatellite instability and HLA class I expression. Their HLA ligandome was characterized using mass spectrometry, compared with the HLA ligand atlas and HLA class I-binding affinity was predicted. Cryptic peptides were identified using Peptide-PRISM. Patients’ Tc were isolated from

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Bourdeau, Annie, Nadia Dubé, Krista M. Heinonen, Jean-François Théberge, Karen M. Doody та Michel L. Tremblay. "TC-PTP–deficient bone marrow stromal cells fail to support normal B lymphopoiesis due to abnormal secretion of interferon-γ". Blood 109, № 10 (2007): 4220–28. http://dx.doi.org/10.1182/blood-2006-08-044370.

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Abstract The T-cell protein tyrosine phosphatase (TC-PTP) is a negative regulator of the Jak/Stat cytokine signaling pathway. Our study shows that the absence of TC-PTP leads to an early bone marrow B-cell deficiency characterized by hindered transition from the pre-B cell to immature B-cell stage. This phenotype is intrinsic to the B cells but most importantly due to bone marrow stroma abnormalities. We found that bone marrow stromal cells from TC-PTP−/− mice have the unique property of secreting 232-890 pg/mL IFN-γ. These high levels of IFN-γ result in 2-fold reduction in mitotic index on IL

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Specht, Christoph, Hans-Gerd Pauels, Christian Becker, and Eckehart Kölsch. "Differential Activation of CD8+Tumor-Specific Tc1 and Tc2 Cells by an IL-10-Producing Murine Plasmacytoma." Developmental Immunology 6, no. 3-4 (1998): 331–42. http://dx.doi.org/10.1155/1998/93545.

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The involvement of counteractiveCD8+T-cell subsets during tumor-specific immune responses was analyzed in a syngeneic murine plasmacytoma model.CD8+Tc cells against the immunogenic IL-10-producing BALB/c plasmacytoma ADJ-PC-5 can be easily induced by immunization of BALB/c mice with X-irradiated ADJ-PC-5 tumor cellsin vivoandin vitro. However, the failure of recipient mice to mount a protective Tc response against the tumor during early stages of a real or simulated tumor growth is not due to immunological ignorance, but depends on the induction of tumor-specific tolerance, involving a populat

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Schuetz, F., C. Sachsenweger, J. Rom, et al. "Interactions of breast cancer cells and tumorantigen-reactive T-cells derived from bone marrow." Journal of Clinical Oncology 25, no. 18_suppl (2007): 13517. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.13517.

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13517 Breast cancer is an immunogenic tumor which is usually recognized by the cellular immunosystem via tumor-associated antigens (TAA) presented by antigen-presenting cells like dendritic cells. Although we were able to find tumorantigen-reactive CD8+CD45R0+ T-memory cells (TMC) in the bone marrow of 67% of primary breast cancer patients by using interferon-?-ELISPOT-analysis there seem to be a minority of non-responers. In comparison to classic tumor characteristics non-responders can be find more often in non-differentiated, hormone-receptor negative tumors. In a phase-1 trial of a cellula

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Komatsuda, Hiroki, Michihisa Kono, Risa Wakisaka, et al. "Harnessing Immunity to Treat Advanced Thyroid Cancer." Vaccines 12, no. 1 (2023): 45. http://dx.doi.org/10.3390/vaccines12010045.

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The incidence of thyroid cancer (TC) has increased over the past 30 years. Although differentiated thyroid cancer (DTC) has a good prognosis in most patients undergoing total thyroidectomy followed by radioiodine therapy (RAI), 5–10% of patients develop metastasis. Anaplastic thyroid cancer (ATC) has a low survival rate and few effective treatments have been available to date. Recently, tyrosine kinase inhibitors (TKIs) have been successfully applied to RAI-resistant or non-responsive TC to suppress the disease. However, TC eventually develops resistance to TKIs. Immunotherapy is a promising t

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Chen, Cheng, Lu Qin, and Mei-Fang Xiao. "Long Noncoding RNA LOC554202 Predicts a Poor Prognosis and Correlates with Immune Infiltration in Thyroid Cancer." Computational and Mathematical Methods in Medicine 2022 (February 28, 2022): 1–12. http://dx.doi.org/10.1155/2022/3585626.

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Thyroid cancer (TC) is one of the widely diagnosed carcinomas in women before the age of 30. Nevertheless, there is currently a lack of specific biomarkers for predicting the prognosis of TC. Long noncoding RNAs (lncRNAs) were important regulators in human cancer progression as previously described. Unfortunately, there is little known on these lncRNAs’ functions and molecular mechanisms in TC. In our literature, we found that LOC554202 (MIR31HG) was upregulated in TC samples and correlated with clinicopathological features, including M stage, N stage, and lymph nodes examined status in TC. In

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