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1

Terence, MD, KA Abdul Razak, S. Jagjoth, and WL Tan. "GUNSHOT INDUCED HUMERUS FRACTURE TREATED USING THE MASQUELET TECHNIQUE." Orthopaedic Journal of Sports Medicine 8, no. 5_suppl5 (2020): 2325967120S0003. http://dx.doi.org/10.1177/2325967120s00038.

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Humerus fractures secondary to gunshot injury are slow to unite and may require multiple surgeries to obtain union. 1We report a gunshot induced humerus fracture treated via the Masquelet technique. Report: A 27-year old gentleman had a shotgun injury to his left arm exposing the humerus bone. He underwent debridement and external fixator and a 4cm segmental bone loss was noted. The following debridement, a humeral nail and 3cm acute shortening was done, as well as the 1st stage Masquelet (Figure 1). After 6 weeks, the 2nd stage Masquelet was performed (Figure 2). At 1 year follow up, radiogra
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2

Thiyagarajan U, Senthil Loganathan, Raghavendar, and Pradeep P. "The deleterious relationship of Pseudomonas aeruginosa and Induced Membranes in infected non-union treatment." International Journal of Research in Pharmaceutical Sciences 12, no. 1 (2021): 388–91. http://dx.doi.org/10.26452/ijrps.v12i1.4032.

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The Masquelet technique was originally described for the treatment of an infected non-union with an extensive bone defect where a staged protocol was needed to first eliminate an infection then secondarily bone graft a defect. Though this is a versatile technique, certain limitations/ complications must be recognized. The study was done between 2012 to 2019 at SRIHER university. 19 patients in whom the Masquelet technique has failed is taken into study. 17 male and two females, with a mean age of 31 years (range of 13 yrs. – 51 yrs.) with a mean follow up of 12 months. The 19 patients who pres
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3

De, Somnath, Nikhilesh Das, Sudipto Mukherjee, and Sabyasachi Bardhan. "Management of Segmental Bone Defects Using Masquelet Technique." Indian Journal of Emergency Medicine 2, no. 2 (2016): 105–8. http://dx.doi.org/10.21088/ijem.2395.311x.2216.3.

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4

Masquelet, Alain, Nikolaos K. Kanakaris, Laurent Obert, Paul Stafford, and Peter V. Giannoudis. "Bone Repair Using the Masquelet Technique." Journal of Bone and Joint Surgery 101, no. 11 (2019): 1024–36. http://dx.doi.org/10.2106/jbjs.18.00842.

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5

Taylor, Benjamin C., Thomas Zink, and Sean McGowan. "Masquelet Technique for Chest Wall Reconstruction." JBJS Case Connector 10, no. 1 (2020): e0011-e0011. http://dx.doi.org/10.2106/jbjs.cc.19.00011.

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6

Alassaf, Nabil, Amro Alhoukail, Abdullah Alsahli, and Ghazi Althubaiti. "Salvage of mangled upper extremity using the Masquelet technique in a child: A case report." SAGE Open Medical Case Reports 5 (January 1, 2017): 2050313X1774101. http://dx.doi.org/10.1177/2050313x17741011.

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Aim: To report our experience with the Masquelet concept in a pediatric upper extremity following an open injury to the elbow. Methods: A case report and literature review. Results: An 11-year-old boy was transferred to our institution after a motor vehicle collision. There was a primary loss of the ulnohumeral articulation and the surrounding soft tissues as well as the ulnar nerve. Reconstruction used the Masquelet-induced membrane technique and a soft tissue flap. At the 30-month follow-up, the extremity was pain free and functional. Conclusion: This case highlights the value of the Masquel
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7

Borzunov, D. Yu, D. S. Mokhovikov, S. N. Kolchin, and E. N. Gorbach. "Combined use of the Ilizarov non-free bone plasty and Masquelet technique in patients with acquired bone defects and pseudarthrosis." Genij Ortopedii 26, no. 4 (2020): 532–38. http://dx.doi.org/10.18019/1028-4427-2020-26-4-532-538.

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Introduction The Masquelet induced membrane technique is effective in the management of acquired heterogeneous long bone defects and pseudarthrosis. The combination of the Masquelet technology and Ilizarov non-free bone grafting seems promising and reduces the risks of recurrence at long-term in patients with congenital pseudarthrosis. Purpose Presentation of new technological solutions that allow combining the advantages of the Ilizarov bone transport and Masquelet bone grafting in patients with acquired bone defects. Materials and methods Retrospective assessment of the results of bone recon
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8

Blair, C., A. T. Simela, and B. J. Cross. "A Challenging Case of Limb Salvage Requiring a Combination of Composite Fixation and Masquelet Technique to Address Significant Segmental Bone Loss." Case Reports in Orthopedics 2015 (2015): 1–5. http://dx.doi.org/10.1155/2015/369469.

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Cases of limb salvage following skeletal trauma involving significant bone loss pose a particular challenge to the reconstructive surgeon. Certain techniques for addressing this complex issue have been advanced in recent years and have met with considerable success. The Masquelet technique involves a staged procedure in which a temporary skeletal stabilization is paired with implantation of an antibiotic spacer and left in place for 6–8 weeks, during which time a “pseudomembrane” forms around the cement spacer. During the second stage of the procedure, the pseudomembrane is incised, the antibi
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9

Tanner, Michael C., Sonja Boxriker, Patrick Haubruck, et al. "Expression of VEGF in Peripheral Serum Is a Possible Prognostic Factor in Bone-Regeneration via Masquelet-Technique—A Pilot Study." Journal of Clinical Medicine 10, no. 4 (2021): 776. http://dx.doi.org/10.3390/jcm10040776.

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Two-step Masquelet-technique established a new procedure in the treatment of osseous defects, addressing prerequisites postulated by the “diamond concept”. Increase in blood perfusion and growth factors are enhanced by the “Masquelet-membrane”. To describe this, we measured serum levels of Vascular Endothelial Growth Factor (VEGF) of patients with atrophic non-unions of long bones undergoing Masquelet-technique. From over 500 non-union patients undergoing Masquelet-technique with prospective follow-up we randomly selected 30 patients. 23 were included, 7 lost to follow-up or excluded because o
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10

Pelissier, P., V. Bollecker, D. Martin, and J. Baudet. "Reconstruction du pied par la technique « bi-Masquelet »." Annales de Chirurgie Plastique Esthétique 47, no. 4 (2002): 304–7. http://dx.doi.org/10.1016/s0294-1260(02)00123-1.

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11

Wong, Tak Man, Tak Wing Lau, Xin Li, Christian Fang, Kelvin Yeung, and Frankie Leung. "Masquelet Technique for Treatment of Posttraumatic Bone Defects." Scientific World Journal 2014 (2014): 1–5. http://dx.doi.org/10.1155/2014/710302.

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Masquelet technique, which is the use of a temporary cement spacer followed by staged bone grafting, is a recent treatment strategy to manage a posttraumatic bone defect. This paper describes a series of 9 patients treated with this technique of staged bone grafting following placement of an antibiotic spacer to successfully manage osseous long bone defects. The injured limbs were stabilized and aligned at the time of initial spacer placement. In our series, osseous consolidation was successfully achieved in all cases. This technique gives promising result in the management of posttraumatic bo
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12

Agarwal, Digvijay, and Rajesh Maheshwari. "Masquelet technique : A promising technique for infected & gap non-unions." Journal of Bone and Joint Diseases 35, no. 1 (2020): 26–28. http://dx.doi.org/10.13107/jbjd.2020.v35i01.007.

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13

Garabano, Germán, César Pesciallo, Alfredo Montero Vinces, Diego José Gómez, Fernando Bidolegui, and Alberto Cid Casteulani. "Defectos óseos segmentarios infectados en huesos largos: tratamiento con técnica de Masquelet.[Masquelet technique for the treatment of infected segmental long-bone defects]." Revista de la Asociación Argentina de Ortopedia y Traumatología 84, no. 1 (2019): 15–26. http://dx.doi.org/10.15417/issn.1852-7434.2019.84.1.853.

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Introducción: Los defectos óseos segmentarios infectados son entidades de complejo tratamiento. La técnica de Masquelet representa una alternativa para estos casos. El objetivo de este estudio retrospectivo, multicéntrico fue mostrar los resultados clínicos y radiológicos obtenidos con esta técnica de reconstrucción en defectos óseos segmentarios infectados de fémur y tibia, caracterizar los defectos tratados y describir los diferentes aspectos de la técnica quirúrgica.Materiales y Métodos: Analizamos a 24 pacientes (14 hombres y 10 mujeres; edad promedio 36.16 años [rango 18-67]) tratados con
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14

Singh, Dr Suryakant, Dr Hitesh Dawar, Dr Deepak Raina, Dr Surbhit Rastogi, and Dr Neha Chaudhary. "Masquelet technique for treatment of post-traumatic bone defects." International Journal of Orthopaedics Sciences 6, no. 2 (2020): 694–700. http://dx.doi.org/10.22271/ortho.2020.v6.i2k.2122.

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15

Mühlhäusser, Julia, Jörg Winkler, Reto Babst, and Frank J. P. Beeres. "Infected tibia defect fractures treated with the Masquelet technique." Medicine 96, no. 20 (2017): e6948. http://dx.doi.org/10.1097/md.0000000000006948.

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16

Lindsey, Ronald W., and Lloyd Resnick. "Masquelet Induced Membrane Technique Helps Fill Many Bone Voids." JBJS Case Connector 6, no. 3 (2016): e67. http://dx.doi.org/10.2106/jbjs.cc.16.00160.

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17

Lum, Zachary C., Lily Park, Kathryn E. Huff, and Mohamed A. Ibrahim. "The Masquelet Technique for Thumb Metacarpal Reconstruction Following Trauma." JBJS Case Connector 8, no. 1 (2018): e19-e19. http://dx.doi.org/10.2106/jbjs.cc.17.00019.

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18

WEAM F. MOUSA, M.D., AHMED M. LASHIN, M. Sc, and MOHAMED M. HOSNI, M. D. EL-SAYED M.E. EL-FORSE, M.D. "Induced Membrane (Masquelet) Technique for Treatment of Long Bone Defects." Medical Journal of Cairo University 86, March (2018): 215–22. http://dx.doi.org/10.21608/mjcu.2018.55079.

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19

Mathieu, Laurent, Emilie Bilichtin, Marjorie Durand, et al. "Masquelet technique for open tibia fractures in a military setting." European Journal of Trauma and Emergency Surgery 46, no. 5 (2019): 1099–105. http://dx.doi.org/10.1007/s00068-019-01217-y.

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20

Neupane, Bikash, Zhao Meng, Xu Sheng Kang, et al. "Clinical study of Masquelet technique in the treatment of osteomyelitis and bone defect." International Journal of Research in Orthopaedics 7, no. 5 (2021): 901. http://dx.doi.org/10.18203/issn.2455-4510.intjresorthop20213374.

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<p class="abstract"><strong>Background:</strong> The induced membrane technique, introduced by Masquelet in 1986 called Masquelet technique is universally preferred methods of treatment in bone defect either of any cause. Consists of two principle steps: first radical debridement and filling defect with polymethylmethacrylate (PMMA) spacer, this allows the formation of induction membrane. Secondly bone cement is removed and defect is filled with bone graft and stabilized with definitive fixation.</p><p class="abstract"><strong>Methods:</strong> This pr
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21

Mak, May Fong, Richard Stern, and Mathieu Assal. "Masquelet Technique for Midfoot Reconstruction Following Osteomyelitis in Charcot Diabetic Neuropathy." JBJS Case Connector 5, no. 2 (2015): e28. http://dx.doi.org/10.2106/jbjs.cc.n.00112.

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22

O’Malley, Natasha T., and Stephen L. Kates. "Advances on the Masquelet technique using a cage and nail construct." Archives of Orthopaedic and Trauma Surgery 132, no. 2 (2011): 245–48. http://dx.doi.org/10.1007/s00402-011-1417-z.

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23

Dhar, Shabir A., Tahir A. Dar, and Naseer A. Mir. "Management of Infected Nonunion of the Forearm by the Masquelet Technique." Strategies in Trauma and Limb Reconstruction 14, no. 1 (2019): 1–5. http://dx.doi.org/10.5005/jp-journals-10080-1411.

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24

Morelli, Ilaria, Lorenzo Drago, David A. George, Enrico Gallazzi, Sara Scarponi, and Carlo L. Romanò. "Masquelet technique: myth or reality? A systematic review and meta-analysis." Injury 47 (December 2016): S68—S76. http://dx.doi.org/10.1016/s0020-1383(16)30842-7.

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25

Ma, Ching-Hou, Yen-Chun Chiu, Kun-Ling Tsai, Yuan-Kun Tu, Cheng-Yo Yen, and Chin-Hsien Wu. "Masquelet technique with external locking plate for recalcitrant distal tibial nonunion." Injury 48, no. 12 (2017): 2847–52. http://dx.doi.org/10.1016/j.injury.2017.10.037.

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26

Mi, Meng, Costas Papakostidis, Xinbao Wu, and Peter V. Giannoudis. "Mixed results with the Masquelet technique: A fact or a myth?" Injury 51, no. 2 (2020): 132–35. http://dx.doi.org/10.1016/j.injury.2019.12.032.

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27

Issaoui, Hichem, Mohammed Reda Fekhaoui, Moheddin Jamous, and Alain-Charles Masquelet. "Modified Masquelet Technique Using Allogeneic Graft for a Gustilo-Anderson Type III-A Open Fracture of the Femur with an 8 cm Bone Defect." Case Reports in Orthopedics 2021 (March 10, 2021): 1–7. http://dx.doi.org/10.1155/2021/8829158.

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The induced membrane technique was initially described by Masquelet et al. in 1986 as a treatment for tibia nonunion; then, it became one of the established methods in the management of bone defects. Several changes have been made to this technique and have been used in different contexts and different methodologies. We present the case of a 16-year-old girl admitted to our department for a polytrauma after a motorcycle accident. She presented a Gustilo III-A open fracture of the right femoral shaft with a large bone defect of 8 centimeters that we treated with a modified Masquelet technique.
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Ronga, Mario, Sergio Ferraro, Alessandro Fagetti, Mario Cherubino, Luigi Valdatta, and Paolo Cherubino. "Masquelet technique for the treatment of a severe acute tibial bone loss." Injury 45 (December 2014): S111—S115. http://dx.doi.org/10.1016/j.injury.2014.10.033.

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29

Raven, T. F., A. Moghaddam, C. Ermisch, et al. "Use of Masquelet technique in treatment of septic and atrophic fracture nonunion." Injury 50 (October 2019): 40–54. http://dx.doi.org/10.1016/j.injury.2019.06.018.

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30

Micev, Alan J., David M. Kalainov, and Alexander P. Soneru. "Masquelet Technique for Treatment of Segmental Bone Loss in the Upper Extremity." Journal of Hand Surgery 40, no. 3 (2015): 593–98. http://dx.doi.org/10.1016/j.jhsa.2014.12.007.

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31

Zhang, Laifu, Chengyin Lu, Yaqing Lv, Xiaohui Wang, Shaoyong Guo, and Hailong Zhang. "Three‐Dimensional Printing‐Assisted Masquelet Technique in the Treatment of Calcaneal Defects." Orthopaedic Surgery 13, no. 3 (2021): 876–83. http://dx.doi.org/10.1111/os.12873.

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32

Qu, Wenqiang, Chi Wei, Li Yu, et al. "Three-Stage Masquelet Technique and One-Stage Reconstruction to Treat Foot and Ankle Tuberculosis." Foot & Ankle International 41, no. 3 (2019): 331–41. http://dx.doi.org/10.1177/1071100719890854.

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Background: The purpose of this article was to report the feasibility and effectiveness of 3-stage Masquelet technique and 1-stage operation for different stages of foot and ankle tuberculosis (TB). Methods: Ten consecutive patients with foot and ankle TB were retrospectively analyzed between January 2014 and December 2018. Five patients were treated with the 3-stage Masquelet technique, including thorough debridement with vacuum sealing drainage, implantation of antibiotic cement spacer, and subsequent reconstruction. Five patients were treated with a 1-stage reconstruction. The American Orth
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33

Miskiel, Sandra A., Steven A. Caruso, and Andre J. Pagliaro. "Masquelet Technique for Hindfoot Fusion of Gustilo IIIA Open Ankle Dislocation with Complete Talar Extrusion and Loss." Foot & Ankle Orthopaedics 4, no. 4 (2019): 2473011419S0030. http://dx.doi.org/10.1177/2473011419s00307.

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Category: Hindfoot, Trauma, Ankle Introduction/Purpose: Complete talar extrusion is a rare injury resulting from high-energy trauma, with dissociation of the talus from surrounding bony and soft-tissue structures. Complications after complete talar extrusion include infection, osteonecrosis, posttraumatic osteoarthritis, and leg-length discrepancy. There is a lack of consensus on the optimal treatment algorithm for complete talar extrusion, due in part to high complication rates associated with injury and treatment. Thus, we report a staged treatment method utilizing the Masquelet Technique wi
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34

Ayouba, Gamal, François Lemonne, Noufanangue Kanfitine Kombate, Batarabadja Bakriga, James Yaovi Edem, and Uzel André-Pierre Max. "Interest of nailing associated with the Masquelet technique in reconstruction of bone defect." Journal of Orthopaedics 20 (July 2020): 228–31. http://dx.doi.org/10.1016/j.jor.2019.12.014.

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35

Carroll, John J., Chance Henderson, Jeff Watson, Karl Larsen, and Ky Kobayashi. "Interposition Arthroplasty of the Elbow After Proximal Ulna Reconstruction With the Masquelet Technique." JBJS Case Connector 10, no. 2 (2020): e0084-e0084. http://dx.doi.org/10.2106/jbjs.cc.19.00084.

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36

Gouron, Richard, François Deroussen, Marie Juvet-Segarra, Marie-Christine Plancq, and Louis-Michel Collet. "Reconstruction of Congenital Pseudarthrosis of the Clavicle with Use of the Masquelet Technique." JBJS Case Connector 2, no. 4 (2012): e77. http://dx.doi.org/10.2106/jbjs.cc.l.00095.

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37

Liu, Zengbing, and Dong Huang. "An Experience of the Modified Masquelet Technique in Treating Segmental Metacarpophalangeal Bone Defects." Journal of Biomaterials and Tissue Engineering 9, no. 4 (2019): 511–16. http://dx.doi.org/10.1166/jbt.2019.2004.

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38

Giannoudis, Peter V., Omar Faour, Thomas Goff, Nikolaos Kanakaris, and Rozalia Dimitriou. "Masquelet technique for the treatment of bone defects: Tips-tricks and future directions." Injury 42, no. 6 (2011): 591–98. http://dx.doi.org/10.1016/j.injury.2011.03.036.

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39

Durand, Marjorie, Laure Barbier, Laurent Mathieu, et al. "Towards Understanding Therapeutic Failures in Masquelet Surgery: First Evidence that Defective Induced Membrane Properties are Associated with Clinical Failures." Journal of Clinical Medicine 9, no. 2 (2020): 450. http://dx.doi.org/10.3390/jcm9020450.

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The two-stage Masquelet induced-membrane technique (IMT) consists of cement spacer-driven membrane induction followed by an autologous cancellous bone implantation in this membrane to promote large bone defect repairs. For the first time, this study aims at correlating IMT failures with physiological alterations of the induced membrane (IM) in patients. For this purpose, we compared various histological, immunohistochemical and gene expression parameters obtained from IM collected in patients categorized lately as successfully (Responders; n = 8) or unsuccessfully (Non-responders; n = 3) treat
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40

Luangphakdy, Viviane, Elizabeth G. Pluhar, Nicolás S. Piuzzi, et al. "The Effect of Surgical Technique and Spacer Texture on Bone Regeneration: A Caprine Study Using the Masquelet Technique." Clinical Orthopaedics and Related Research 475, no. 10 (2017): 2575–85. http://dx.doi.org/10.1007/s11999-017-5420-8.

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41

Sahu, Anil Kumar, Bhabani Sankar Lenka, and Chandan Kumar Panda. "Masquelet technique for treatment of open tibia fracture with bone loss: An observational study." International Journal of Orthopaedics Sciences 5, no. 3 (2019): 387–90. http://dx.doi.org/10.22271/ortho.2019.v5.i3g.1558.

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42

Litvina, Elena A., and Anton A. Semenistyy. "A case report of extensive segmental defect of the humerus treated with Masquelet technique." Journal of Shoulder and Elbow Surgery 29, no. 7 (2020): 1368–74. http://dx.doi.org/10.1016/j.jse.2020.03.018.

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43

Moghaddam, A., C. Ermisch, and G. Schmidmaier. "OS8-55 Use of Masquelet technique in treatment of septic and atrophic non-union." Injury 47 (October 2016): S21—S22. http://dx.doi.org/10.1016/s0020-1383(16)30541-1.

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44

Huffman, Lanie K., John G. Harris, and Michael Suk. "Using the Bi-Masquelet Technique and Reamer-Irrigator-Aspirator for Post-traumatic Foot Reconstruction." Foot & Ankle International 30, no. 9 (2009): 895–99. http://dx.doi.org/10.3113/fai.2009.0895.

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45

Mauffrey, Cyril, Peter V. Giannoudis, Janet D. Conway, Joe R. Hsu, and Alain-Charles Masquelet. "Masquelet technique for the treatment of segmental bone loss have we made any progress?" Injury 47, no. 10 (2016): 2051–52. http://dx.doi.org/10.1016/j.injury.2016.09.018.

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46

Stella, Marco, Emmanuele Santolini, Alberto Autuori, Lamberto Felli, and Federico Santolini. "Masquelet technique to treat a septic nonunion after nailing of a femoral open fracture." Injury 49 (December 2018): S29—S33. http://dx.doi.org/10.1016/j.injury.2018.11.017.

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47

Kang, Yongqiang, Yongwei Wu, Yunhong Ma, et al. "“Primary free-flap tibial open fracture reconstruction with the Masquelet technique” and internal fixation." Injury 51, no. 12 (2020): 2970–74. http://dx.doi.org/10.1016/j.injury.2020.10.039.

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48

Luttenberger, Martin, Feras Taqatqeh, Adrian Dragu, and Olimpiu Bota. "Thumb Reconstruction after Severe Trauma Using the Masquelet Technique and the Foucher Neurovascular Flap." Plastic and Reconstructive Surgery - Global Open 8, no. 9 (2020): e3097. http://dx.doi.org/10.1097/gox.0000000000003097.

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49

Luengo-Alonso, Gonzalo, Ismael Auñon Martin, Victor Rodriguez Vega, Aranzazu Capel Agundez, and Pedro Caba Doussoux. "Long term results of lower limb posttraumatic acute bone defects treated with masquelet technique." Injury 52 (July 2021): S99—S103. http://dx.doi.org/10.1016/j.injury.2021.02.057.

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50

Thakur, Lokesh, Sarvesh Kumar Singh, Sunny Dua, Devinder Kumar, and Manish Sharma. "Masquelet technique for management of posttraumatic bone defect in a patient of chronic osteomyelitis of long bone." International Journal of Research in Orthopaedics 7, no. 3 (2021): 691. http://dx.doi.org/10.18203/issn.2455-4510.intjresorthop20211634.

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<p class="abstract">Masquelet technique, which is the use of a temporary cement spacer followed by staged bone grafting, is a treatment strategy for reconstruction of large, infected, bone defects. This paper describes a patient treated with this technique to successfully manage postinfective or posttraumatic osseous long bone defect. Sequestrectomy was done and the injured limb was stabilized and aligned with application of external fixator at the time of initial antibiotic cement spacer placement. After 6 weeks of proper antibiotic coverage, all antibiotics were stopped for next 2 week
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