Relevant bibliographies by topics / Techniques de double hybride

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Academic literature on the topic 'Techniques de double hybride'

Author: Grafiati
Published: 4 June 2021
Last updated: 15 February 2022

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Journal articles on the topic "Techniques de double hybride"

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Sharma, Sam, Takahiro Hiratsuka, Hisashi Hara, and Jeffrey Milsom. "Antigravity ESD – double-balloon-assisted underwater with traction hybrid technique." Endoscopy International Open 06, no. 06 (June 2018): E739—E744. http://dx.doi.org/10.1055/a-0578-8081.

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Abstract Background and study aims Complex colorectal polyps or those positioned in difficult anatomic locations are an endoscopic therapeutic challenge. Underwater endoscopic submucosal dissection (UESD) is a potential technical solution to facilitate efficient polyp removal. In addition, endoscopic tissue retraction has been confined to limited methods of varying efficacy and complexity. The aim of this study was to evaluate the efficiency of a unique UESD technique for removing complex polyps using double-balloon-assisted retraction (R). Materials and methods Using fresh ex-vivo porcine rectum, 4-cm polyps were created using electrosurgery and positioned at “6 o’clock” within an established ESD model. Six resections were performed in each group. Underwater techniques were facilitated using a novel double-balloon platform (Dilumen, Lumendi, Westport, Connecticut, United States).Three different polypectomy methods were compared: 1. UESD with retraction (UESD-R), 2. UESD, 3. Traditional cap-assisted ESD technique. Results UESD-R had a significantly shorter total procedural time than cap-assisted ESD and UESD alone (24 vs. 58 vs. 56 mins). UESD-R produced a dissection time on average of 5 minutes, attributed to the retraction provided. There was also a subjective significant reduction in electrosurgical smoke with the underwater techniques contributing to improved visualization. Conclusions Here we report the first ex-vivo experience of a unique double-balloon endoscopic platform optimized for UESD with tissue traction capability. UESD-R removed complex lesions in significantly shorter time than conventional means. The combined benefits of UESD and retraction appeared to be additive when tackling complex polyps and should be studied further.
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Lee, Jaehan, Seoni Kim, Choonsoo Kim, and Jeyong Yoon. "Hybrid capacitive deionization to enhance the desalination performance of capacitive techniques." Energy Environ. Sci. 7, no. 11 (2014): 3683–89. http://dx.doi.org/10.1039/c4ee02378a.

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Ezzaoua, Mr Omar. "On Double Narration in Wuthering Heights." American Research Journal of English and Literature 7, no. 1 (May 28, 2021): 1–4. http://dx.doi.org/10.21694/2378-9026.21006.

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Emily Bronte's Wuthering Heights is characterized by the narrative mechanisms and techniques it employs. Building on its structure, the novel is obviously rich in its underlying elements that are worth examining. One of these elements is the choice of multiple narrators and the complex organization of narrative time. This theoretical framework deals mainly with narration and narrative techniques as approached by structuralist narratology. As an approach that examines narration and its major hybrids, narratology delves into a structural study of Wuthering Heights allowing for a deep examination of the underlying narrative elements in the novel. Having said that, it is believed that the study of narratology is pertaining in the sense that it sheds light on how the narrative structure of the novel puts into question the status of the narrators as reliable sources. This structure also mystifies the story giving the reader a chance to decipher the intent of the characters involved as both narrators and characters. Without taking such structure into account, the readers are missing some key elements in understanding and interpreting the stories told by the narrators
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Steinberg, Christian, Maximilian Rumler, Manuel Runkel, Marc Papenheim, Si Wang, Andre Mayer, Marco Becker, Mathias Rommel, and Hella-Christin Scheer. "Complex 3D structures via double imprint of hybrid structures and sacrificial mould techniques." Microelectronic Engineering 176 (May 2017): 22–27. http://dx.doi.org/10.1016/j.mee.2017.01.009.

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Ghirri, Alberto, Samuele Cornia, and Marco Affronte. "Microwave Photon Detectors Based on Semiconducting Double Quantum Dots." Sensors 20, no. 14 (July 19, 2020): 4010. http://dx.doi.org/10.3390/s20144010.

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Detectors of microwave photons find applications in different fields ranging from security to cosmology. Due to the intrinsic difficulties related to the detection of vanishingly small energy quanta ℏ ω , significant portions of the microwave electromagnetic spectrum are still uncovered by suitable techniques. No prevailing technology has clearly emerged yet, although different solutions have been tested in different contexts. Here, we focus on semiconductor quantum dots, which feature wide tunability by external gate voltages and scalability for large architectures. We discuss possible pathways for the development of microwave photon detectors based on photon-assisted tunneling in semiconducting double quantum dot circuits. In particular, we consider implementations based on either broadband transmission lines or resonant cavities, and we discuss how developments in charge sensing techniques and hybrid architectures may be beneficial for the development of efficient photon detectors in the microwave range.
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Romero, Jorge, María Varela, Mhamed Assebban, Víctor Oestreicher, Alejandra Guedeja-Marrón, Jose L. Jordá, Gonzalo Abellán, and Eugenio Coronado. "Insights into the formation of metal carbon nanocomposites for energy storage using hybrid NiFe layered double hydroxides as precursors." Chemical Science 11, no. 29 (2020): 7626–33. http://dx.doi.org/10.1039/d0sc00697a.

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The low-temperature formation mechanism of NiFe-carbon magnetic nanocomposites prepared using hybrid sebacate intercalated layered double hydroxides as precursors has been deciphered using a set of in situ characterization techniques.
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Yang, Fan, Xichuan Liu, Rui Mi, Lei Yuan, Xi Yang, Minglong Zhong, Zhibing Fu, Chaoyang Wang, and Yongjian Tang. "A Novel Radiation Method for Preparing MnO2/BC Monolith Hybrids with Outstanding Supercapacitance Performance." Nanomaterials 8, no. 7 (July 14, 2018): 533. http://dx.doi.org/10.3390/nano8070533.

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A novel facile process for fabrication of amorphous MnO2/bamboo charcoal monolith hybrids (MnO2/BC) for potential supercapacitor applications using γ-irradiation methods is described. The structural, morphological and electrochemical properties of the MnO2/BC hybrids have been investigated using X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM), cyclic voltammetry (CV), galvanostatic charge/discharge (GCD) and electrochemical impedance spectroscopy (EIS) techniques. The combination of BC (electrical double layer charge) and MnO2 (pseudocapacitance) created a complementary effect, which enhanced the specific capacitance and good cyclic stability of the MnO2/BC hybrid electrodes. The MnO2/BC hybrids showed a higher specific capacitance (449 F g−1 at the constant current density of 0.5 A g−1 over the potential range from –0.2 V to 0.8 V), compared with BC (101 F g−1) in 1 M of Na2SO4 aqueous electrolyte. Furthermore, the MnO2/BC hybrid electrodes showed superior cycling stability with 78% capacitance retention, even after 10,000 cycles. The experimental results demonstrated that the high performance of MnO2/BC hybrids could be a potential electrode material for supercapacitors.
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Xie, Hui Min, Yan Jie Li, Hua Du, Bing Pan, Qiang Luo, Chang Zhi Gu, and Hai Chang Jiang. "The Technique for Fabricating Submicron Moiré Grating Using FIB Milling." Advanced Materials Research 47-50 (June 2008): 710–13. http://dx.doi.org/10.4028/www.scientific.net/amr.47-50.710.

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In this study, focused gallium ion (Ga+) beam is utilised to fabricate micro/submicron spacing gratings on specimen surface. The grating types include: parallel, cross, and hybrid (grating with double-frequency). Several hybrid gratings with double frequency were produced in combination mode or superposition mode, which have a good potential to measure deformation within different range. Techniques for producing different type of gratings are discussed in detail. As an application, a 5000 lines/mm grating was fabricated on an amorphous SIC MEMS cantilever and was successfully used to measure its virtual strain with aid of digital moiré. The experimental results verify the feasibility of fabricating high frequency grating on metal or non-metal surface using the FIB milling and the resultant grating can be used to measure micro-deformation.
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Niazkar, Majid, and Seied Hosein Afzali. "Parameter estimation of an improved nonlinear Muskingum model using a new hybrid method." Hydrology Research 48, no. 5 (October 28, 2016): 1253–67. http://dx.doi.org/10.2166/nh.2016.089.

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Although various techniques have been proposed to estimate the parameters of different versions of the Muskingum model, more rigorous techniques and models are still required to improve the computational precision of the calibration process. In this research, a new hybrid technique was proposed for Muskingum parameter estimation. Based on the conducted comprehensive literature review on the Muskingum flood routing models, a new improved Muskingum model with nine constant parameters was presented. Since the inflow-weighted parameter in the proposed model is a function of inflow hydrograph, it varies during the flood period and consequently can also be considered as a variable-parameter Muskingum model. The new hybrid technique was successfully applied for parameter estimation of the new version of Muskingum model for two case studies selected from the literature. Results were compared with those of other methods using several common performance evaluation criteria. The new Muskingum model significantly reduces the sum of the square of the deviations between the observed and routed outflows (SSQ) value for the double-peak case study. Finally, the obtained results indicate that not only the hybrid modified honey bee mating optimization-generalized reduced gradient algorithm somehow overcomes the shortcomings of both zero and first-order optimization techniques, but also the new Muskingum model appears to be the most reliable Muskingum version compared with the other methods considered in this study.
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Amaloo, Christopher, Daryl P. Nazareth, and Lalith K. Kumaraswamy. "Comparison of hybrid volumetric modulated arc therapy (VMAT) technique and double arc VMAT technique in the treatment of prostate cancer." Radiology and Oncology 49, no. 3 (September 1, 2015): 291–98. http://dx.doi.org/10.1515/raon-2015-0018.

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Abstract Background. Volumetric modulated arc therapy (VMAT) has quickly become accepted as standard of care for the treatment of prostate cancer based on studies showing it is able to provide faster delivery with adequate target coverage and reduced monitor units while maintaining organ at risk (OAR) sparing. This study aims to demonstrate the potential to increase dose conformality with increased planner control and OAR sparing using a hybrid treatment technique compared to VMAT. Methods. Eleven patients having been previously treated for prostate cancer with VMAT techniques were replanned with a hybrid technique on Varian Treatment Planning System. Multiple static IMRT fields (2 to 3) were planned initially based on critical OAR to reduce dose but provide some planning treatment volume (PTV) coverage. This was used as a base dose plan to provide 30-35% coverage for a single arc VMAT plan. Results. The clinical VMAT plan was used as a control for the purposes of comparison. Average of all OAR sparing between the hybrid technique and VMAT showed the hybrid plan delivering less dose in almost all cases except for V80 of the bladder and maximum dose to right femoral head. PTV coverage was superior with the VMAT technique. Monitor unit differences varied, with the hybrid plan able to deliver fewer units 37% of the time, similar results 18% of the time, and higher units 45% of the time. On average, the hybrid plan delivered 10% more monitor units. Conclusions. The hybrid plan can be delivered in a single gantry rotation combining aspects of VMAT with regions of dynamic intensity modulated radiation therapy (IMRT) within the treatment arc.
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Dissertations / Theses on the topic "Techniques de double hybride"

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Abdel, Gawwad Mohamed Ragab. "Révélation des interactions spécifiques des membres de la famille des TRX et leurs cibles potentielles, par la technique de la double hybride." Perpignan, 2008. http://www.theses.fr/2008PERP0930.

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Les thiorédoxines (TRX) sont de petites protéines (≈ 12kDa) avec un pont disulfure actif redox actuel dans le site actif caractéristique CxxC (Schürmann et Jacquot, 2000). Ce site actif est conservé dans beaucoup d'autre TRXs de différents organismes et est considéré comme signature desTRX. Le motif structural de TRX se compose de 4 hélices alpha entourant 5 feuillets bêta. Les TRXs ont été trouvés chez les procaryotes et les eucaryotes, la région autour du site active est fortement conservée. Un certain nombre de protéines escarotiques contiennent des domaines TRX conservés au cours de l'évolution, bon nombre d'entre elles font partie de la famille de protéines isomérase disulfide (PDI). Sous leur forme réduite elles constituent des oxydoréductases très efficaces de protéine disulfide. Le nombre de gènes de TRX dans les organismes non-photosynthetiques est relativement limité si on le compare à celui des organismes photosynthétiques. 42 gènes codant pour les TRXs avec un site actif CXXC ou CXXS et de grandes protéines contenant au moins un domaine de TRX (TRX-like protéines) ont été identifiés dans le génome d'Arabidopsis thaliana. Les progrès considérables dans l'identification de nouvelles cibles de TRX ont complètement changé cette situation suggérant que les TRX constituent des régulateurs centraux du métabolisme des cellules en plusieurs compartiments sous-cellulaires. En dépit de l'utilisation de différents isoforms de TRX connus pour rechercher des préférences parmi les cibles des TRX, aucune spécificité n'a été montrée en utilisant les approches biochimiques. Dans ce travail, on a utilisé une approche d'interaction par double hybride à l'aide de deux systèmes: certaines thioredoxines interagissent avec leurs cibles de manière stable par interactions de charges électrostatiques ou hydrophiles hydrophobes. Ces interactions peuvent être mises en évidence dans un système double hybride commercial. Pour la plupart des TRX l'interaction est trop fugace et ne peut être mise en évidence qu'en stabilisant le complexe intermédiaire qui associe la TRX et sa cible par un pont disulfure. Dans une levure double hybride commerciale le complexe est détruit par les TRX endogènes et aucun signal n'est observé. Nous avons utilisé la souche cy306 (souche de levure rapporteur dont les TRX endogènes ont été inactivées) et nous avons pu ainsi démontrer des interactions TRX cibles. On a étudié deux systèmes redox classiques chloroplastique TRXf/FBpase et TRXm/MDH ainsi que les interactions entre certaines TRX h cytosoliques et une MDH cytosolique. Les résultats obtenus montrent que cette approche double hybride révèle mieux que les test d'activité ou la protéomique la spécificité d'interaction des TRX pour leurs cibles
TRXs are small proteins (≈ 12 kDa) with a redox active disulfide bridge present in the characteristic active site CxxC (Schürmann and Jacquot, 2000). It was found that this active site is conserved in many other TRXs from different organisms and was considered as a special signature for TRX. The structural motif of TRX is composed of 4 alpha helices surrounding 5 beta strands. TRXs have been found in both prokaryotes and eukaryotes and the sequence around the redox-active disulphide bond seems to be highly conserved. A number of eukaryotic proteins contain domains evolutionary related to thioredoxin, many of them are part of the protein disulphide isomerase (PDI) family. In their reduced form they constitute very efficient protein disulfide oxido-reductases. The number of TRX genes in non-photosynthetic organisms is relatively limited if it compared to that of photosynthetic organisms. Genes encoding TRXs with a CXXC or CXXS active site and large proteins containing at least one TRX domain (TRX-like proteins) are considered, 42 genes can be identified in the genome of Arabidopsis thaliana. The considerable progress in the identification of new TRX targets has completely changed this situation and suggests that TRXs could constitute central regulators of cell metabolism in several subcellular compartments. Despite the use of different TRX isoforms known to exhibit distinct preferences for TRX targets, no specificity has been observed biochemical approaches. In this work, we have used CY306 Y2H a new tool in which the two endogene TRX are deleted to bring the specificity between TRXs and their targets. We have studied both classical redox system; TRXf/FBPase and TRXm/MDH. In this work, we used an approach of Yeast-two hybrid: some thioredoxins interact with their targets in a stable way by interactions of electrostatic or absorbent loads hydrophobic. These interactions can be highlighted in a system commercial yeast two hybrid. For the majority of the TRX the interaction is too fugacious and can be highlighted only by stabilizing the intermediate complex which associates the TRX and its target by a bridge disulfide. In a commercial Y2H the complex doubles is destroyed by the endogenous TRX and no signal is observed. We used the stock cy306 (yeast strain stock in which endogenous TRX were inactivated) and we thus could show target interactions TRX. One studied two systems strain redox chloroplastic TRXf/FBpase and TRXm/MDH as well as the interactions between certain cytosolic TRX h and a cytosolic MDH. The results obtained show that this approach doubles hybrid reveals better than the test of activity or proteomic the specificity of interaction of the TRX for their targets
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Védrine-Bochard, Valérie. "Étude des interactions entre Int6 et les protéines cellulaires." Lyon, École normale supérieure (sciences), 2001. http://www.theses.fr/2001ENSL0197.

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La protéine Int6 humaine, localisée à la fois dans le noyau et le cytoplasme, a initialement été caractérisée comme une cible de la protéine oncogénique Tax du rétrovirus HTLV-I. La fonction de cette protéine, exprimée à la fois chez S. Pombe, les plantes et les mammifères n’a pas été encore élucidée. Cependant les publications récentes montrent qu’elle est associée à au moins deux complexes multiprotéiques à domaine PCI : le facteur d’initiation de la traduction eIF3, et le signalosome COP9. Mes travaux sur la fonction d’Int6 ont débuté par la réalisation d’un criblage en double hybride dans la levure des protéines humaines interagissant avec Int6. Nous avons ainsi mis en évidence puis confirmé l’interaction Int6 avec la sous-unité MCM7 du complexe MCM d’initiation de la réplication. Cette interaction a été l’objet principal de mes recherches durant ma thèse. Nous avons ainsi confirmé l’interaction d’Int6 avec les protéines MCM4, 6 et 7 par co-immunoprécipitation des protéines endogènes. L’analyse du complexe Int6-MCM7 dans des cellules Jurkat synchronisées a montré que ce complexe se formait essentiellement en phase G1 et se dissociait en phase S. Chez le xénope, l’intéraction d’Int6 avec MCM7 est détectée dans des extraits mitotiques d’œufs. Dans ce système d’étude, l’introduction d’un excès de protéine Int6 recombinante inhibe la réplication in vitro. La multiplicité des interacteurs mis en évidence (Rfp, eIF3, COP9, MCM) et les différentes fonctions affectées (cycle cellulaire, traduction, réplication) impliquent donc qu’Int6 joue un rôle important au sein de la cellule
The int6 gene was originally identified as a frequent site of integration of the MMTV provirus in preneoplastic and neoplastic mammary lesions. The human cDNA encoding Int6 was independently isolated in a two-hybrid screen for cellular proteins interacting with the Tax oncoprotein of HTLV-1. Finally, the Int6 protein was shown to correspond to a subunit of purified eIF3 translation initiation factor. Its presence in eIF3 has been established in the following organisms : rabbit, S. Pombe et A. Thaliana. In A. Thaliana Int6 has also been shown to associate with the signalosome via binding to the CSN7 subunit of this complex. A two-hybrid screen performed with the Int6 protein as bait showed that it binds the Ret finger protein (Rfp) which interacts with PML and localises with a subset of PML nucear bodies. Int6 and Rfp are co-localised in certain PML nuclear bodies in lymphocytes. Another clones were interesting with respect to recent publications indicating interactions between eIF3, signalosome and proteasome complexes : CSN3, a subunit of signalosome, and Rpt4, a subunit of 19D proteasome. Finally, the two-hybrid screen showed that Int6 binds to MCM7, a component of MCM complex. Analysis of this interaction indicated that it intervenes between normal endogenous proteins in primary cells. Experiments with synchronised cells established that Int6 binds MCM7 in a cell cycle dependent manner during mitosis and G1. The Int6 protein also exists in Xenopus. Its association with the MCM complex was observed only with metaphase-arrested egg extract but not interphase extract. In vitro DNA replication assays using the Xenopus system showed that addition of purified In-6 has an inhibitory effect. These results suggest that Int6 regulates the activity of the MCM complex through an interaction with its MCM7 subunit. They also support a possible link between oncogenesis and the control of the licensing activity
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Truong, Nhat My. "Analyse fonctionnelle des effecteurs nucléaires du parasitisme des nématodes à galle Meloidogyne incognita et caractérisation de leurs cibles végétales." Thesis, Université Côte d'Azur (ComUE), 2016. http://www.theses.fr/2016AZUR4149.

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Le nématode à galle, Meloidogyne incognita est un parasite extrêmement polyphage capable d'induire la redifférentiation de cellules racinaires en cellules en cellules nourricières hypertrophiées
The root-knot nematode Meloidogyne incognita is among the most devastating plant pathogens
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Brault, Jean-Baptiste. "Etude de l'interaction entre la protéine de membrane des flavivirus et la chaîne légère de dynéineTcex-1." Paris 7, 2011. http://www.theses.fr/2011PA077055.

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Les flavivirus transmis par les moustiques comme le virus de la dengue (DENV), le virus West-Nile (WNV), le virus de la fièvre jaune (YFV) ou encore de l'encéphalite japonaise (JEV) sont des virus émergents ou ré-émergents qui représentent une menace pour l'Homme. Ces virus sont composés d'une nucléocapside recouverte d'une enveloppe lipidique dans laquelle sont enchâssées les deux protéines de structure: la protéine d'enveloppe E, nécessaire à l'entrée du virus dans la cellule, et la protéine de membrane M. La protéine de membrane est synthétisée sous la forme d'un précurseur prM qui est clivé en fin de cycle. Le rôle que joue la protéine prM/M au cours du cycle viral n'est pas bien compris. Cette étude avait pour objectif d'identifier des partenaires cellulaires de cette protéine virale afin de mieux en comprendre la fonction. Ces travaux ont permis d'identifier, par la technique du double-hybride ainsi que par purification d'affinité par capture de GST, la chaîne légère de dynéine Tctex-1 comme étant un interacteur cellulaire de l'ectodomaine de la protéine M (ectoM). L'établissement de mutants de l'ectoM a permis d'isoler un acide aminé essentiel pour l'interaction avec la protéine Tctex-1. Des expériences d'ARN interférence visant à éteindre l'expression de la protéine Tctex-1 ont induit une diminution de la production de particules virales de WNV et DENV. La même extinction dans des cellules exprimant des particules vides constituées de prM et de E a permis de déterminer que ce facteur cellulaire est important pour les étapes tardives du cycle infectieux. Ce mécanisme semble indépendant du transport rétrograde du moteur dynéine h Ions des microtubules
Mosquito-borne flaviviruses such as dengue (DENV), West-Nile (WNV), yellow fever (YFV) or Japanese encephalitis (JEV) viruses are now Worldwide emerging or reemerging infectious threats. These viruses consist of a nucleocapsid surrounded by a lipidic membrane containing the two viral structural proteins: the E envelope protein, involved in entry of the virus into its target cell, and the small M membrane protein. The membrane protein is synthesized as a precursor prM that is cleaved late in the viral life cycle. The role that prM/M plays during the viral life cycle remains to be investigated. In this study we sought to identify for the first time new cellular interactors of this protein in order to better understand its function. Using a yeast two-hybrid screen and GSTpull-down assays, we identified the dynein light chain protein Tctex-1 as a cellular interactor of the ectodomain of the M protein (ectoM). Engineering of mutants of the ectoM allowed us to pinpoint a single amino-acid that is important for the interaction with Tctex-1. Silencing of Tctex-1 expression using RNA interference prior to infection induced a significant decrease of DENV and WNV viral progeny production. Silencing Tctex-1 expression in a stable cell line expressing recombinant subviral particles highlighted a role of this cellular factor in the late steps of the viral life cycle. This mechanism seems to be independent from the dynein motor complex retrograde transport along microtubules
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Fang, Lei. "Exploring Constraint Satisfiability Techniques in Formal Verification." Diss., Virginia Tech, 2008. http://hdl.handle.net/10919/27573.

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Due to the widespread demands for efficient Propositional Satisfiability (SAT) solvers and its derivatives in Electronic Design Automation applications, methods to boost the performance of the SAT solver are highly desired. This dissertation aims to enhance the performance of SAT and related SAT solving problems. A hybrid solution to boost SAT solver performance is proposed as an initial attack in this dissertation, via an integration of local and DPLL-based search approaches. Next, a different hybrid strategy is attempted that takes advantage of the conflicts in the SAT search, which plays a critical role in modern SAT solvers. Usually a learned conflict-induced clause is added back to the clause database. Although conflict-induced clauses help to block a portion of the search space, they can also become a burden due to the added cost in memory consumption and Boolean Constraint Propagation (BCP). We thus propose a novel double-layer conflict-driven learning to store only those "primary" conflict clauses back into the clause database while keeping the other clauses as pseudo Boolean constraints. With this approach our experiments demonstrate that the approach can improve both in performance and memory consumption. This work opens the door on how to assess the usefulness of conflict induced clauses. Besides the aforementioned works about enhancing SAT solver performance and reducing memory cost, this dissertation also proposed a contributing work on the extended SAT problem solving. The current SAT solvers can provide an assignment for a satisfiable propositional formula. However, the capability for a SAT solver to return an "optimal" solution for a given objective function is severely lacking. MIN-ONE SAT is an optimization problem which requires the satisfying assignment with the minimal number of Ones, and it can be easily extended to minimize an arbitrary linear objective function. While some research has been conducted on MIN-ONE SAT, the existing algorithms do not scale very well on large formulas. This dissertation presents a novel approximation algorithm (RelaxSAT) for MIN-ONE SAT. RelaxSAT generates a set of constraints from the objective function to guide the search. The constraints are gradually relaxed to eliminate the conflicts with the original Boolean SAT formula until a solution is found. The experiments demonstrate that RelaxSAT is able to handle very large instances which cannot be solved by existing MIN-ONE algorithms; furthermore, RelaxSAT is able to obtain a very tight bound on the solution with one to two orders of magnitude speedup. Based on the proposed powerful MIN-ONE SAT algorithm, we built a MAX-SAT solver which achieved more than one order of magnitude speed up compared with the-state-of-art MAX-SAT solver. We also discuss a promising application of this MAX-SAT solver in formal verification.
Ph. D.
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Maiga, Oumou. "Rôle de la protéine "Disc Large" dans les cellules de la paroi vasculaire humaine." Paris 7, 2012. http://www.theses.fr/2012PA077024.

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Les protéines d'architecture jouent un rôle fondamental dans l'organisation des réseaux d'interactions protéiques. Ces protéines sont constituées de multiples domaines d'interaction protéine-protéine leur permettant de participer au regroupement, à l'adressage fonctionnel et à la coordination des activités des différents membres d'un complexe multiprotéique. Au cours de ce travail, nous nous sommes intéressés à l'expression et aux fonctions d'un membre de la famille des protéines d'architecture « membrane-associatedguanylate kinase » (MAGUK), la protéine « Disc large » (Dlg), aussi connue sous le nom de « synapse-associatedprotein-97 », dans les cellules constitutives de la paroi vasculaire humaine. Afin d'appréhender le rôle de Dlg dans ces cellules, nous avons cherché à identifier ses protéines partenaires à travers deux méthodes protéomiques, la technique du double hybride chez la levure, et celle de la co-immunoprécipitation couplée à la spectrométrie de masse. L'analyse des interactions mises en évidence a permis de suggérer l'implication de Dlg dans la régulation de la voie de signalisation « extracellular signal-responsive kinase » (ERK) dans les cellules musculaires lisses vasculaires, et sa contribution dans le trafic intracellulaire dans les cellules endothéliales microvasculaires. L'ensemble de ce travail permet de mieux comprendre la fonction de Dlg dans la paroi vasculaire et offre de nouvelles perspectives d'études
Scaffold proteins play a key role in the organization of protein interaction networks. These proteins are made of multiple protein-protein interaction domains that allow them to bring together different members of a multiprotein complex, to address this complex at specific areas of the cell and to coordinate its activities. In this work, we looked for the expression and functions of a member of the architecture protein family, membrane-associated guanylate kinase (MAGUK), the protein Disc large (Dlg), also known as the synapse-associated protein-97, in the human vessel wall. Thus, we show for the first time the expression of this protein in vascular smooth muscle cells and in microvascular endothelial cells. In order to understand the role of Dlg in these cells, we sought to identify their partner proteins through two proteomic approaches, the yeast two-hybrid method, and co-immunoprecipitation coupled with mass spectrometry. The analysis of identified interactions has highlighted the involvement of Dlg in the regulation o extracellular signal-responsive kinase (ERK) signaling pathway in smooth muscle cells, and suggests its contribution to the intracellular trafficking in endothelial cells. This work provides insight into the function of Dlg in the vascular wall and offers new perspectives for studies
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Samson, Jérôme. "Conception d'inhibiteurs du domaine SH3 de la protéine RasGAP à activité anti-tumorale potentielle." Paris 5, 2005. http://www.theses.fr/2005PA05P607.

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Au sein de la voie Ras, fréquemment impliquée dans les tumeurs humaines, la protéine RasGAP joue un rôle particulier, à la fois régulateur négatif et effecteur de Ras. RasGAP-SH3 a déjà été identifiée comme une cible thérapeutique pertinente par plusieurs équipes. Par un crible double-hybride, nous avons obtenu des protéines synthétiques (aptamères), interagissant spécifiquement avec le domaine SH3 de RasGAP, et exprimés dans des cellules tumorales provoque une diminution de leur capacité à former des colonies et de leur viabilité cellulaire. Nous avons synthétisé les peptides responsables de leur interaction avec RasGAP-SH3, et mesuré leur affinité. Nous avons ainsi obtenu un peptide cyclique dont l'affinité est de l'ordre du micromolaire, et dont l'empreinte sur le SH3 a été déterminée par RMN. Ces données structurales permettront de modifier nos peptides, afin d'en augmenter affinité, et activité sur cellules en culture. L'activité anti-tumorale de ces molécules sera ensuite évaluée
Within the Ras pathway, frequently implicated in human tumors, the RasGAP protein plays two apparently contrary roles, both as a negative regulator and a positive effector. Its SH3 domain has already been identified as a relevant anti-tumoral target. Using peptide aptamers obtained by yeast two-hybrid screening, we bring a new validation of this target: we have discovered synthetic proteins specifically interacting with RasGAP-SH3. Moreover, when expressed in tumor cells, they decrease their colony-forming capacity and their cell viability. We have synthesized peptides derived from their variable loops, responsible for the interaction with RasGAP-SH3, and evaluated their affinity. Our best molecule is a sub-micromolar-affinity cyclic peptide, which binding fingerprint on the SH3 has been determined by NMR. These structural data will guide modifications of our peptides, in order to increase their affinity and cell-penetrating capacity. Their antitumoral properties will then be assessed
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Abdessamad, Mahmoud. "Caractérisation moléculaire et fonctionnelle des signalosomes PTEN/MAGI-1b/TRIP6 et PTEN/PTPN13." Paris 7, 2012. http://www.theses.fr/2012PA077048.

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Le suppresseur de tumeurs PTEN est une phosphatase capable de déphosphoryler certains résidus tyrosine, mais également les phosphoinositides produits de la PI3K. Dans son extrémité C- terminale, PTEN comporte un motif d'interaction avec les domaines PDZ. Notre équipe a établi le rôle majeur de l'activité lipide-phosphatase dans la stabilisation des contacts cellulaires et le contrôle de l'invasion. PTEN est recruté vers les jonctions cellulaires E-cadhérine β-caténine, via la molécule à domaines PDZ MAGI-1. Afin d'identifier de nouveaux partenaires de PTEN, nous avons engagé une approche par le système de double hybrides. Cette approche a permis d'identifier TRIP6 et PTPN13. Nous avons montré que TRIP6 induit l'invasion des cellules épithéliales MDCK, via i) la compétition avec les (3-caténines pour lier MAGI-1 et la déstabilisation des complexes jonctionnels, ii) l'activation des voies de signalisations dépendantes de la PI3K et de NFKB (FASEB J 23:916,2009). PTPN13 est une tyrosine phosphatase qui comporte 5 domaines PDZ. Nous avons confirmé l'interaction de PTEN avec le domaine PDZ2 de PTPN13 in vitro et ex vivo. Nous avons montré que PTEN est substrat de PTPN13 in vitro. De même, la surexpression de PTPN13 native, mais pas d'une forme défective dans l'activité phosphatase, induit une diminution de la phosphorylation de PTEN. Cette surexpression n'affecte pas le niveau de phosphorylation de Akt -reflet de l'activité de cette kinase- dans des lignées déficientes en PTEN, mais potentialise les effets inhibiteurs de PTEN sur cet effecteur de la PI3K. Par conséquent, nos résultats démontrent le rôle critique de PTPN13 dans le contrôle de la signalisation dépendante de PTEN
The PTEN tumor suppressor is a multifunctional protein endowed with a phosphatase activity that dephosphorylates not only some phosphotyrosine residues, but also the phosphoinositides generated by PI3K. In its C-terminus, PTEN encodes a PDZ-binding motif. Our Team has demonstrated the critical role of the lipid phosphatase activity of PTEN in stabilizing junctional complexes and in reverting invasiveness. PTEN interacts with cadherin β3-catenin complexes through the PDZ domain containing- protein MAGI-1. To identify new molecular PTEN partners, we applied yeast-two-hybrid assay, and identified TRIP6 and PTPN13. We have demonstrated that TRIP6 induces invasiveness of the MDCK epithelial cells, through i) the competition with (3-catenin for binding to MAGI-1 b and the destabilization of junctional complexes, ii) the activation of the PI3K/ Akt, and NFKB signaling pathways (FASEB J 23:916,2009). PTPN13 is a tyrosine phosphatase with 5 PDZ domains. We have confirmed the interaction of PTEN C-terminus with the 2nd PDZ domain of PTPN13 in vitro and ex vivo. We showed that PTEN is a PTPN13 substrate in vitro. In line with these results, the overexpression of wild-type PTPN13, but not of a mutant deficient in phosphatase activity decreased PTEN phosphorylation. This overexpression did not alter Akt phosphorylation -a reflect of the activity of this kinase- in PTEN deficient cell lines, but potentiated PTEN effects on this downstream target of PI3K. Thus, our results demonstrated the critical role of PTPN13 in controling PTEN signaling pathway
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Magnard, Clémence. "Approche fonctionnelle de la protéine codée par le gène de prédisposition au cancer du sein BRCA1 : identification de partenaires protéiques de sa région carboxy-terminale BRCT." Lyon 1, 2002. http://www.theses.fr/2002LYO1T049.

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Mon sujet de thèse a pour objet la protéine codée par le gène majeur de prédisposition au cancer du sein BRCA1. Lorsque j'ai débuté ma thèse, cette protéine étudiée depuis peu semblait impliquée dans différents mécanismes cellulaires tels le contrôle du cycle cellulaire, la différenciation et la réparation de l'ADN. Afin de préciser son rôle biologique, l'objectif de mon travail a été de rechercher des partenaires protéiques de l'un de ses domaines fonctionnels connus : le domaine BRCT (BRCA1 c-terminus). La technique de cosédimentation de lysats cellulaires avec des protéines de fusion à la GST m'a permis d'identifier un premier partenaire majeur du domaine BRCT de la protéine Brca1 murine. Il s'agit d'une protéine cytoplasmique, l'acétyl-coA carboxylase a, enzyme clé du métabolisme des acides gras. L'interaction de l'ACCa avec BRCA1 a été confirmée in vitro et in vivo, et est conservée chez la souris et chez l'homme. J'ai également pu montrer que la présence simultanée des deux modules du domaine BRCT est requise pour la liaison de l'ACCa sur BRCA1, et que des mutations prédisposant au cancer situées dans cette région abolissent l'interaction de BRCA1 avec l'ACCa. Un criblage en deux-hybride chez la levure m'a également permis d'isoler neuf partenaires potentiels du domaine BRCT de Brca1. A ce jour, l'interaction de trois d'entre eux avec la protéine BRCA1 a pu être confirmée in vitro et in vivo. Il s'agit de la protéine de liaison aux queues poly(A) des ARN messagers PABP, du répresseur de la traduction NAT1 ou eIF4G2 et de la protéine à empreinte parentale PEG10. Au total, l'identification de ces partenaires de la protéine BRCA1 dévoile des facettes inattendues de sa fonction et ouvre de nouvelles perspectives pour l'étude de l'implication de BRCA1 dans la tumorigenèse de la glande mammaire.
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Ménade, Marie. "Étude de complexes ribonucléoprotéiques impliqués dans la régulation de l'expression des protéines au cours de l'initiation de la traduction." Phd thesis, Grenoble 1, 2007. http://www.theses.fr/2007GRE10133.

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L'expression génique est régulée à de nombreuses étapes de la vie cellulaire. La synthèse des protéines ou traduction, étape ultime de cette expression, est finement régulée. Elle comporte trois phases: l'initiation, l'élongation et la terminaison. L'initiation commence par l'établissement de la sous-unité ribosomique 40S sur cet ARNm qu'elle balaye ensuite jusqu'au codon initiation. Pour cela, des facteurs canoniques sont impliqués. Parmi eux, le facteur elF3 interagit directement avec celle-ci. Au cours de mes travaux, j'ai étudié dans une première partie l'interaction putative entre le facteur elF3 et la petite sous-unité ribosomique 40S. Le ribosome est constitué par deux types d'entités: des protéines ribosomiques et l'ARNr. Lefacteur eIF3, contient au moins 13 sous-unités, dont deux possèdent un RRM, et sont potentiellement capables de lier cet ARNr via leur RRM: p44 et p116. ElF3p44 a montré auparavant qu'elle pouvait lier l'ARNr l8S. J'ai effectué un criblage d'une banque de ftagments de cet ARNr pour identifier un site de liaison de p44 sur la sous-unité 40S. Les ARNm néo-synthétisés sont transportés et localisés afin de permettre l'expression des protéines aumoment opportun et en un lieu précis de la cellule. Dans une deuxième partie, j'ai étudié des interactions impliquées dans le contrôle de l'initiation de la traduction d'un ARNm localisé chez la levure S. Cerevisiae pendant son transport: l'ARNm ASHI. Il est régulé par Khdlp, protéine à trois domaines KH, qui lie directement un de ses éléments de localisation. Cette interaction est abolie par la phosphorylation de Khd 1 P lorsque l'ARNm est correctement localisé
Gene expression is ftequently regulated during cellular life. Protein synthesis, also called translation, is the last part ofthat expression and is wholly regulated. Translation is divided in three parts: initiation, elongation and termination. Initiation starts when the 40S ribosomal subunit binds the mRNA and scans it until it reaches the initiation codon. Many initiation factors are involved. Among them, elF3 directly binds that subunit. During my work, 1 studied in a first part the putative interaction between the factor eIF3 and the small ribosomal subunit 40S. The ribosome is constituted oftwo different entities: ribosomal proteins and rRNA. The factor elF3 contains at least 13 subunits. Two possess a RRM and are potentially able to bind that rRNA vif their RRM: p44 et p 116. ElF3p44 showed previously that it was able to bind l8S rRNA. 1 screened a library of 18S rRNA fragments with the aim of identifying a binding site ofp44 on the 40S subunit. The newly synthesized mRNAs are transported and localized into the cytoplasm to control spatiall~ and temporally protein expression. Ln a second part, 1 studied the interactions involved in translation initiation control of aS. Cerevisiae localized mRNA, ASH1, during its transport. Its regulation is mediated through its direct interaction with Khdlp, a three KH domain protein, on one ofits RNA localization elements. This interaction is abolished by Khdlp phosphorylation when ASHI mRNA is welliocalized
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Books on the topic "Techniques de double hybride"

1

Hongler, Peter. Hybride Finanzierungsinstrumente im nationalen und internationalen Steuerrecht der Schweiz. Zürich: Schulthess, 2011.

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El-Homossani, M. M. Double-harness techniques employed in Egypt. Winnipeg: [Charles Babbage Research Centre], 1985.

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Double cross: Deception techniques in war. Somerville, Massachusetts: Candlewick Press, 2017.

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Hybride Finanzierungsinstrumente im deutschen und US-amerikanischen Steuerrecht: Eine Analyse ihres grenzüberschreitenden Einsatzes aus steuersystematischer und ökonomischer Sicht. Frankfurt am Main: P. Lang, 1996.

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Lang, Michael. Hybride Finanzierungen im internationalen Steuerrecht: Rechtsgrundlagen der Doppelbesteuerungsabkommen zur Beurteilung von Mischformen zwischen Eigen- und Fremdkapital. Wien: A. Orac, 1991.

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Columbia College (Chicago, Ill.). Midwest Photographers Publication Project., ed. Double life. New York, N.Y: Aperture, 2006.

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Rosiér, Keith. Studio bass masters: Session tips & techniques from top bass players. San Francisco: Miller Freeman Books, 1999.

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1917, Dudley Geoffrey A., ed. Double your learning power: Master the techniques of successful memory and recall. Wellingborough: Thorsons, 1986.

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na. Double Bass Solo Techniques: A Book Of Orchestral Excerpts / Edited By Keith Ha. S.I: Oxford University Press, 2008.

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Sales magic: Revolutionary new techniques that will double your sales volume in 21 days. New York: Morrow, 1994.

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Book chapters on the topic "Techniques de double hybride"

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Wertz, John E., and James R. Bolton. "Double-resonance Techniques." In Electron Spin Resonance, 353–77. Dordrecht: Springer Netherlands, 1986. http://dx.doi.org/10.1007/978-94-009-4075-8_13.

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Tsvetkov, Yuri D., Michael K. Bowman, and Yuri A. Grishin. "Experimental Techniques." In Pulsed Electron–Electron Double Resonance, 37–65. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-030-05372-7_2.

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Bussewitz, Bradly W., Christopher W. Reb, and David Larson. "The Medial Double Arthrodesis." In Essential Foot and Ankle Surgical Techniques, 197–208. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-14778-5_20.

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Worley, Charles E., and Geoffrey G. Douglass. "The New Index Catalog of Visual Double Stars — WDS." In Astrometric Techniques, 649–51. Dordrecht: Springer Netherlands, 1986. http://dx.doi.org/10.1007/978-94-009-4676-7_81.

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Teague, E. T. H., and R. W. Argyle. "Simple Techniques of Measurement." In Observing and Measuring Visual Double Stars, 149–67. New York, NY: Springer New York, 2012. http://dx.doi.org/10.1007/978-1-4614-3945-5_12.

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Legnaioli, Stefano, Giulia Lorenzetti, Lorenzo Pardini, Gildo H. Cavalcanti, and Vincenzo Palleschi. "Double and Multiple Pulse LIBS Techniques." In Springer Series in Optical Sciences, 117–41. Berlin, Heidelberg: Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-642-45085-3_5.

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Demtröder, Wolfgang. "Optical Pumping and Double-Resonance Techniques." In Advanced Texts in Physics, 567–607. Berlin, Heidelberg: Springer Berlin Heidelberg, 2003. http://dx.doi.org/10.1007/978-3-662-05155-9_10.

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Temes, Gabor C. "Autozeroing and Correlated Double Sampling Techniques." In Analog Circuit Design, 45–64. Boston, MA: Springer US, 1996. http://dx.doi.org/10.1007/978-1-4757-2462-2_3.

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Demtröder, Wolfgang. "Optical Pumping and Double-Resonance Techniques." In Laser Spectroscopy 2, 225–69. Berlin, Heidelberg: Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-662-44641-6_5.

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Demtröder, Wolfgang. "Optical Pumping and Double-Resonance Techniques." In Laser Spectroscopy, 552–93. Berlin, Heidelberg: Springer Berlin Heidelberg, 1996. http://dx.doi.org/10.1007/978-3-662-08260-7_10.

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Conference papers on the topic "Techniques de double hybride"

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Gutierrez, Louis Alberto, Paolo Pezzini, David Tucker, and Larry Banta. "Smoothing Techniques for Real-Time Turbine Speed Sensors." In ASME Turbo Expo 2014: Turbine Technical Conference and Exposition. American Society of Mechanical Engineers, 2014. http://dx.doi.org/10.1115/gt2014-25407.

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A data noise reduction model for a direct-fired fuel cell turbine hybrid power system was evaluated using a hardware-based simulation of an integrated gasifier/fuel cell/turbine hybrid cycle (IGFC), implemented through the Hybrid Performance (HyPer) project at the National Energy Technology Laboratory, U.S. Department of Energy (NETL). The Hyper facility is designed to explore dynamic operation of hybrid systems and quantitatively characterize such transient behavior. The system is controlled by an embedded real-time control platform provided by Woodward Industrial Control. Every sensor is monitored by the platform, and an overall strategy drives the system from start-up to shut-down. Fuel is regulated by a valve which reacts based on the speed of the turbine. There are three optical encoder sensors which are used to monitor turbine speed, and the average of these three sensors is used as feedback for a PID controller, which works to regulate fuel consumption to the combustor. The turbine speed has demonstrated fluctuation in certain conditions, which may be a result of data noise combined with a systemic instability in the flow to the turbine. This research introduces the method of Double Exponential Smoothing as it is applied to data noise reduction in an embedded control platform. An experimental test was conducted to evaluate the performance of the fuel valve speed control when filtered by a real-time Double Exponential Smoothing Algorithm. The results demonstrate, that when compared with traditional filtering techniques, Double Exponential Smoothing offers a significant improvement in both signal volatility and data latency.
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Paret, Paul, Joshua Major, Douglas DeVoto, Sreekant Narumanchi, Yansong Tan, and Guo-Quan Lu. "Mechanical Characterization Study of Sintered Silver Pastes Bonded in a Double-Lap Configuration." In ASME 2018 International Technical Conference and Exhibition on Packaging and Integration of Electronic and Photonic Microsystems. American Society of Mechanical Engineers, 2018. http://dx.doi.org/10.1115/ipack2018-8276.

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Sintered silver-based bonded interfaces are a critical enabling technology for high-temperature, compact, high-performance, and reliable wide-bandgap packages and components. High-pressure (∼40 MPa) sintered silver interfaces have been implemented commercially, most notably the commercial products offered by Semikron. To reduce manufacturing complexity, there is significant industry interest in pressure-less sintered silver interfaces. To this end, current formulations of sintered silver paste are comprised of purely nano-sized silver particles or a combination of nano- and micro-sized silver particles/flakes. It is essential to quantify the mechanical properties and determine the reliability of these interfaces prior to use in automotive power electronics applications. In this paper, research efforts at the National Renewable Energy Laboratory, in collaboration with Virginia Polytechnic Institute and State University and an industry partner, in optimizing the synthesis procedure and mechanical characterization of sintered silver double-lap samples are described. These double-lap samples were synthesized using pressure-less sintering techniques. Shear testing was conducted at multiple temperatures and displacement rates on these samples sintered using two types of sintered sintered silver pastes, one of them consisting of nano-silver particles and the other a hybrid paste or a combination of nano- and micron-sized silver flakes, employed in a double-lap configuration. Maximum values of shear stress obtained from the characterization study are reported.
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Mei, Tianlong, Yi Liu, Manasés Tello Ruiz, Marc Vantorre, Evert Lataire, Changyuan Chen, and Zaojian Zou. "Hybrid Method for Predicting Ship Manoeuvrability in Regular Waves." In ASME 2019 38th International Conference on Ocean, Offshore and Arctic Engineering. American Society of Mechanical Engineers, 2019. http://dx.doi.org/10.1115/omae2019-95249.

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Abstract The ship’s manoeuvring behaviour in waves is significantly different from that in calm water. In this context, the present work uses a hybrid method combining potential flow theory and Computational Fluid Dynamics (CFD) techniques for the prediction of ship manoeuvrability in regular waves. The mean wave-induced drift forces are calculated by adopting a time domain 3D higher-order Rankine panel method, which includes the effect of the lateral speed and forward speed. The hull-related hydrodynamic derivatives are determined based on a RANS solver using the double body flow model. The two-time scale method is applied to integrate the improved seakeeping model in a 3-DOF modular type Manoeuvring Modelling Group (MMG model) to investigate the ship’s manoeuvrability in regular waves. Numerical simulations are carried out to predict the turning circle in regular waves for the S175 container carrier. The turning circle’s main characteristics as well as the wave-induced motions are evaluated. A good agreement is obtained by comparing the numerical results with experimental data obtained from existing literature. This demonstrates that combining potential flow theory with CFD techniques can be used efficiently for predicting the manoeuvring behaviour in waves. This is even more true when the manoeuvring derivatives cannot be obtained from model tests when there is lack of such experimental data.
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Jamal, Tausif, Shanti Bhushan, and D. Keith Walters. "Numerical Simulation of Non-Stationary Turbulent Flows Using Double Exponential Dynamic Time Filtering Technique." In ASME 2020 Fluids Engineering Division Summer Meeting collocated with the ASME 2020 Heat Transfer Summer Conference and the ASME 2020 18th International Conference on Nanochannels, Microchannels, and Minichannels. American Society of Mechanical Engineers, 2020. http://dx.doi.org/10.1115/fedsm2020-20295.

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Abstract Temporally varying turbulent flows are of considerable interest in complex engineering problems such as combustion, hydrodynamics, and hemodynamics. These types of flows are often associated with complex flow physics such as varying mean pressure gradients, interactions of different scales of motion, and complex boundary layer separations. Hybrid Reynolds-averaged Navier-Stokes (RANS)/Large-Eddy Simulation (LES) methods have recently shown promise for accurate and computationally efficient simulation of these flows. One such method is the dyanamic hybrid RANS-LES (DHRL) model which has been demonstrated for numerous statistically stationary turbulent flows. More recently, it has been shown that Exponential Time-Averaging (ETA) and Dynamic Time Filtering (DTF) methods for obtaining resolved flow statistics have significantly improved the predictive capabilities of the Dynamic Hybrid RANS-LES (DHRL) model performance for a non-stationary turbulent flows with periodically time-varying statistics. However, for non-periodic temporally evolving flows with monotonically varying statistics, a more suitable alternative is desired. In this study, the performance of the Dynamic Hybrid RANS-LES (DHRL) model with a double exponential dynamic time filtering (DDTF) methodology is evaluated against a Reynolds-Averaged Navier-Stokes (RANS) model, a conventional Hybrid RANS-LES (HRL) model, implicit LES, and the DHRL model with DTF for a pulsating channel and a temporally-varying turbulent mixing layer. Model performance is evaluated based on comparisons to existing experimental and Direct Numerical Simulation (DNS) results. A comprehensive analysis of the results highlights key similarities and differences between the models and indicates that the use of a double exponential DTF technique improves the accuracy of the baseline DHRL model. It is concluded that the DDTF is a useful alternative to simulate unsteady non-periodic temporally evolving turbulent flows.
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Iyer, Nandini, Eric R. Thompson, and Brian D. Simpson. "Response Techniques and Auditory Localization Accuracy." In The 22nd International Conference on Auditory Display. Arlington, Virginia: The International Community for Auditory Display, 2016. http://dx.doi.org/10.21785/icad2016.032.

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Auditory cues, when coupled with visual objects, have lead to reduced response times in visual search tasks, suggesting that adding auditory information can potentially aid Air Force operators in complex scenarios. These benefits are substantial when the spatial transformations that one has to make are relatively simple i.e., mapping a 3-D auditory space to a 3-D visual scene. The current study focused on listeners’ abilities to map sound surrounding a listener to a 2-D visual space, by measuring performance in localization tasks that required the following responses: 1) Headpointing: turn and face a loudspeaker from where a sound emanated, 2) Tablet: point to an icon representing a loudspeaker displayed in an array on a 2-D GUI or, 3) Hybrid: turn and face the loudspeaker from where a sound emanated and them indicate that location on a 2-D GUI. Results indicated that listeners’ localization errors were small when the response modality was head-pointing, and localization errors roughly doubled when they were asked to make a complex transformation o fauditory-visual space (i.e., while using a hybrid response); surprisingly, the hybrid response technique reduced errors compared to the tablet response conditions. These results have large implications for the design of auditory displays that require listeners to make complex, non-intuitive transformations of auditory-visual space.
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Sabah, C., H. Tugrul Tastan, F. Dincer, M. Karaaslan, E. Unal, and K. Delihacioglu. "Transmission tunneling through the periodic sequence of double-negative and double-positive layers." In 2013 13th Conference on Microwave Techniques (COMITE). IEEE, 2013. http://dx.doi.org/10.1109/comite.2013.6545059.

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Golaraei, Ahmad, Lukas Kontenis, Kamdin Mirsanaye, Yeji Ro, Margarete K. Akens, Brian C. Wilson, and Virginijus Barzda. "Investigation of Collagen Chirality with Double Stokes-Mueller Polarimetry." In Novel Techniques in Microscopy. Washington, D.C.: OSA, 2019. http://dx.doi.org/10.1364/ntm.2019.nm4c.3.

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"Double negative presents." In SIGGRAPH '15: Special Interest Group on Computer Graphics and Interactive Techniques Conference. New York, NY, USA: ACM, 2015. http://dx.doi.org/10.1145/2773215.2773222.

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"Double negative presents." In SIGGRAPH '15: Special Interest Group on Computer Graphics and Interactive Techniques Conference. New York, NY, USA: ACM, 2015. http://dx.doi.org/10.1145/2745234.2773222.

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Pavani, Sri Rama Prasanna, Rafael Piestun, Michael A. Thompson, Julie S. Biteen, and W. E. Moerner. "Three-dimensional super-resolution imaging with a double-helix microscope." In Novel Techniques in Microscopy. Washington, D.C.: OSA, 2009. http://dx.doi.org/10.1364/ntm.2009.nma5.

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Reports on the topic "Techniques de double hybride"

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Mermagen, Timothy J., and Bruce R. Geil. Double-Sided Wafer Alignment Techniques. Fort Belvoir, VA: Defense Technical Information Center, April 1992. http://dx.doi.org/10.21236/ada250757.

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Daymo, E. A. Industrial mixing techniques for Hanford double-shell tanks. Office of Scientific and Technical Information (OSTI), September 1997. http://dx.doi.org/10.2172/555260.

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Jensen, L. ,. Fluor Daniel Hanford. Statistical techniques for characterizing residual waste in single-shell and double-shell tanks. Office of Scientific and Technical Information (OSTI), February 1997. http://dx.doi.org/10.2172/325389.

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