Journal articles: 'Technológa CNS'

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Vesikansa, Aino. "Unraveling of Central Nervous System Disease Mechanisms Using CRISPR Genome Manipulation." Journal of Central Nervous System Disease 10 (January 1, 2018): 117957351878746. http://dx.doi.org/10.1177/1179573518787469.

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The complex structure and highly variable gene expression profile of the brain makes it among the most challenging fields to study in both basic and translational biological research. Most of the brain diseases are multifactorial and despite the rapidly increasing genomic data, molecular pathways and causal links between genes and central nervous system (CNS) diseases are largely unknown. The advent of an easy and flexible CRISPR-Cas genome editing technology has rapidly revolutionized the field of functional genomics and opened unprecedented possibilities to dissect the mechanisms of CNS disease. CRISPR-Cas allows a plenitude of applications for both gene-focused and genome-wide approaches, ranging from original “gene scissors” making permanent modifications in the genome to the regulation of gene expression and epigenetics. CRISPR technology provides a unique opportunity to establish new cellular and animal models of CNS diseases and holds potential for breakthroughs in the CNS research and drug development.

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Gaurina-Međimurec, Nediljka, Karolina Novak-Mavar, and Matej Majić. "CCS TECHNOLOGY: OVERVIEW OF PROJECTS, TECHNOLOGY AND MONITORING." Rudarsko-geološko-naftni zbornik 33, no. 2 (2018): 1–14. http://dx.doi.org/10.17794/rgn.2018.2.1.

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Wang, Hui, Xian-Feng Lin, Li-Ren Wang, Yi-Qian Lin, Jiang-Tao Wang, Wen-Yue Liu, Gui-Qi Zhu, Martin Braddock, Ming Zhong, and Ming-Hua Zheng. "Decellularization technology in CNS tissue repair." Expert Review of Neurotherapeutics 15, no. 5 (March 27, 2015): 493–500. http://dx.doi.org/10.1586/14737175.2015.1030735.

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Ye, Zheng Mao, Li Hua Wan, Mei Liu, and Jun Chang. "Study on Effect of Carbonation Curing for Cement Minerals and Clinker." Key Engineering Materials 477 (April 2011): 79–84. http://dx.doi.org/10.4028/www.scientific.net/kem.477.79.

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As an advanced technology, carbonation reaction could dispose of industrial solid residues and sequestrate CO2 gas, save resources and protect environment. In this study, Major minerals of cement were high-temperature burned using pure chemical reagents ( the burning temperature of C3S, C2S, C3A, C4AF were 1550°C,1400°C,1330°C, 1350°C). Forming and unforming main cement minerals and clinker were carbonated under the condition of CO2 partial pressure P=0.2MPa, T =25°C, CO2 gas concentration c>99.9% and water/soild w/s=0.12kg/kg. The change of minerals and the effect of carbonation were tested. The experimental results showed that carbonation reaction could been occured in four cement minerals (C3S, C2S, C3A and C4AF), and CaCO3 crystals appeared in these minerals. The sequence of carbonation degree of minerals were C3S﹥C2S﹥C4AF﹥C3A. 0.168g and 0.125g CO2 gas could been sequestrated by 1 gramme of C3S and C2S in carbonated curing respectively, and 0.1301g and 0.1464 g CO2 gas could been sequestrated by 1 gramme of formed and powdery clinker. After carbonated curing, clinker samples had high early strength and good soundness, 2h strength was 24.65 MPa and 3d strength was 41.65 MPa.

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Wang, Zhi, Shu-Na Wang, Tian-Ying Xu, Zhu-Wei Miao, Ding-Feng Su, and Chao-Yu Miao. "Organoid technology for brain and therapeutics research." CNS Neuroscience & Therapeutics 23, no. 10 (September 7, 2017): 771–78. http://dx.doi.org/10.1111/cns.12754.

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Harno, Erika, Elizabeth C. Cottrell, and Anne White. "Metabolic Pitfalls of CNS Cre-Based Technology." Cell Metabolism 18, no. 1 (July 2013): 21–28. http://dx.doi.org/10.1016/j.cmet.2013.05.019.

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Witcher, T. R. "Technology Update: CES For CEs." Civil Engineering Magazine Archive 90, no. 4 (April 2020): 70–73. http://dx.doi.org/10.1061/ciegag.0001484.

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Wang, Xiaoxiao, Yan Gao, Changguo Shan, Mingyao Lai, Haixia He, Bing Bai, Li-qin Ping, et al. "Association of Circulating Tumor DNA from the Cerebrospinal Fluid with High-Risk CNS Involvement in Patients with Diffuse Large B-Cell Lymphoma." Blood 136, Supplement 1 (November 5, 2020): 34. http://dx.doi.org/10.1182/blood-2020-134804.

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Diffuse large B-cell lymphoma (DLBCL) patients with central nervous system (CNS) involvement have dismal outcomes. The detection sensitivity of conventional diagnosis of lymphoma through cerebrospinal fluid (CSF) cytology (CC) and flow cytometry (FCM) is restricted. CSF-ctDNA has shown to be an important method of liquid biopsy in patients with CNS cancers. To assess the correlation between CSF-ctDNA and CNS involvement in DLBCL, targeted mutational profiling was performed on CSF- and plasma -derived ctDNA together with matched systemic tumor tissues in 67 DLBCL patients clinically diagnosed as high risk for CNS relapse, using a validated panel of more than 400 genes. We found that ctDNA concentration in CSF but not in plasma correlated with CNS-IPI score in DLBCL patients. In CSF-positive high-risk DLBCL patients, eighty-six gene alterations(GAs) were shared between tumor tissue and CSF while ninety-five were shared between tumor tissue and plasma. Interestingly, forty-eight GAs(CSF-CNS GAs) were identified including 24 GAs exclusively in CSF and 24GAs shared by plasma which enriched in apoptosis/cell cycle related pathway and immunity-related pathway. To better screen for CNS-related molecular features in CSF, GAs in brain tumor tissue and CSF from a PCNSL-DLBCL cohort of 10 patients were sequenced and compared to that in high-risk group. Moreover, GAs in tumor samples from an additional cohort of 40 DLBCL patients clinically diagnosed as low-risk for CNS relapse were sequenced and compared to that in high-risk group to screen out non-CNS-related features. The number of alterations in five CSF-CNS genes including BTG2, PIM1, DUSP2, ETV6, CXCR4 in CSF was found to be associated with CNS risk in DLBCL patients. Our data supported the feasibility of using CSF-ctDNA as a complementary source for early detection of CNS involvement in DLBCL. The association between GAs in five CSF-CNS genes and CNS involvement deserved further investigation to determine their relevance in patient treatment and outcome. Disclosures Yu: Geneseeq Technology Inc: Current Employment. Ou:Geneseeq Technology Inc: Current Employment. Wang:Nanjing Geneseeq Technology Inc: Current Employment. Shao:Nanjing Geneseeq Technology Inc: Current Employment.

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Mnasri, Aida, and Ezzeddine Hadj Taieb. "Simulation numérique par éléments finis des écoulements transitoires à surface libre." La Houille Blanche, no. 5-6 (December 2019): 81–92. http://dx.doi.org/10.1051/lhb/2019032.

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Une simulation numérique par des éléments finis des écoulements transitoires à surface libre dans les canaux prismatiques est présentée. Dans cette étude, l'écoulement est supposé unidirectionnel dans un canal de faible pente. Le modèle mathématique est constitué d'un système de deux équations aux dérivées partielles de type hyperbolique résolu numériquement par la méthode des éléments finis. Pour définir les fonctions d'interpolation dans la forme intégrale des résidus pondérés, la méthode de Galerkin a été utilisée. Dans les applications, différentes sections prismatiques sont examinées. Les régimes transitoires étudiés sont dus à des manœuvres de vanne placée en aval du canal, l'extrémité amont étant connectée à un réservoir de niveau constant. Dans ces conditions, le régime transitoire correspond à une évolution de l'écoulement d'un régime permanent initial vers un régime permanent final. Ces deux régimes sont supposés uniformes à débit constant défini par la formule de Manning. Les résultats obtenus concernent l'évolution des paramètres hydrauliques en différentes sections du canal, suite à la manœuvre en aval. Deux cas de manœuvres sont considérés ; le cas d'une ouverture et le cas d'une fermeture. L'étude a permis d'analyser la propagation des ondes de surface et la réflexion de ces ondes sur les deux extrémités du canal. En particulier, les résultats numériques montrent que lorsque la largeur du lit du canal est très petite (cas de la section triangulaire), les fluctuations des profondeurs sont rapidement amorties.

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Trülzsch, Barbara, and Matthew Wood. "Applications of nucleic acid technology in the CNS." Journal of Neurochemistry 88, no. 2 (December 23, 2003): 257–65. http://dx.doi.org/10.1111/j.1471-4159.2004.02153.x.

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Minh, Vu Trieu, Mart Tamre, Victor Musalimov, Pavel Kovalenko, Irina Rubinshtein, Ivan Ovchinnikov, David Krcmarik, Reza Moezzi, and Jaroslav Hlava. "Model Predictive Control for Modeling Human Gait Motions Assisted by Vicon Technology." Journal Européen des Systèmes Automatisés 53, no. 5 (November 15, 2020): 589–600. http://dx.doi.org/10.18280/jesa.530501.

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Human muscles and the central nervous system (CNS) play the key role to control the human movements and activities. The human CNS determines each human motion following three steps: estimation of the movement trajectory; calculation of required energy for muscles; then perform the motion. In these three step tasks, the human CNS determines the first two steps and the human muscles conduct the third one. This paper efforts the use of model predictive control (MPC) algorithm to simulate the human CNS calculation in the case of gait motion. We first build up the human gait motion mathematical model with 5-link mechanism. This allows us to apply MPC to calculate the optimal torques at each joint and optimal trajectory for muscles. Outcomes of simulations simultaneously are compared with the real human movements captured by the Vicon motion capture technology which is the novelty of this study. Results show that tracking errors are not excessed 7%.

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Jozwiak, Andrzej, Yiwen Liu, Ying Yang, and Monte A. Gates. "Development of a Stereotaxic Device for Low Impact Implantation of Neural Constructs or Pieces of Neural Tissues into the Mammalian Brain." BioMed Research International 2014 (2014): 1–9. http://dx.doi.org/10.1155/2014/651236.

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Implanting pieces of tissue or scaffolding material into the mammalian central nervous system (CNS) is wrought with difficulties surrounding the size of tools needed to conduct such implants and the ability to maintain the orientation and integrity of the constructs during and after their transplantation. Here, novel technology has been developed that allows for the implantation of neural constructs or intact pieces of neural tissue into the CNS with low trauma. By “laying out” (instead of forcibly expelling) the implantable material from a thin walled glass capillary, this technology has the potential to enhance neural transplantation procedures by reducing trauma to the host brain during implantation and allowing for the implantation of engineered/dissected tissues or constructs in such a way that their orientation and integrity are maintained in the host. Such technology may be useful for treating various CNS disorders which require the reestablishment of point-to-point contacts (e.g., Parkinson’s disease) across the adult CNS, an environment which is not normally permissive to axonal growth.

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Feng, Yang, Zhiwen Wang, Ruixue Zhang, Yuanyuan Lu, Yuqing Huang, Hongxiang Shen, Xiaomeng Lv, and Jun Liu. "Anti-fouling graphene oxide based nanocomposites membrane for oil-water emulsion separation." Water Science and Technology 77, no. 5 (December 20, 2017): 1179–85. http://dx.doi.org/10.2166/wst.2017.634.

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Abstract Anti-fouling copper hydroxide nanowires (CHNs)-graphene oxide (GO) nanocomposites membrane was fabricated by a vacuum-assisted filtration self-assembly process. CHNs were covered on the surface and inserted into the interlayers of the GO nanosheets to form the rough surface and nanostructure channels. The membrane with water contact angles (CAs) of 53° and oil CAs of 155° exhibited superior stability, hydrophilicity, underwater superoleophobicity and ultralow oil adhesion, and hence it could separate the oil-water emulsion with a high efficiency of >99%. This membrane showed the combined advantages of high oil rejection rate and ultralow membrane fouling, making it promising for practical oil-water emulsion separation applications.

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Bidwell, Nicola J. "Rural Uncommoning." ACM Transactions on Computer-Human Interaction 28, no. 3 (July 2021): 1–50. http://dx.doi.org/10.1145/3445793.

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Shared use of small-scale natural commons is vital to the livelihoods of billions of rural inhabitants, particularly women, and advocates propose that local telecommunications systems that are oriented by the commons can close rural connectivity gaps. This article extends insights about women's exclusion from such Community Networks (CNs) by considering ‘commoning’, or practices that produce, reproduce and use the commons and create communality. I generated data in interviews and observations of rural CNs in seven countries in the Global South and in multi-sited ethnography of international advocacy for CNs. Male biases in technoculture and rural governance limit women's participation in CNs, and women adopt different approaches to performing their communal identity while using technology. This situation contributes to detaching CNs from relations that are produced in women's commoning. It also illustrates processes that co-opt the commons in rural technology endeavours and the diverse ways commoners express their subjectivities in response.

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ENGELHARDT, K. G. "Current Status and Future Prospects for Robotic Technology in Health Care Delivery." Central Nervous System Trauma 3, no. 1 (January 1986): 111–26. http://dx.doi.org/10.1089/cns.1986.3.111.

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Sajjad, Azeem, Adeleso Adesina, Penelope Halkiadakis, Kelsey Murphy, Kathleen Mulligan, Collin Labak, Olindi Wijesekera, and Tiffany Hodges. "OTHR-04. Gynecological Malignancies With Metastasis To The Central Nervous System: A Case Series and Systematic Review of the Literature." Neuro-Oncology Advances 3, Supplement_3 (August 1, 2021): iii15. http://dx.doi.org/10.1093/noajnl/vdab071.059.

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Abstract Introduction Gynecologic malignancies are an increasingly common proportion of central nervous system metastatic disease. As genetic sequencing technology improves and becomes more accessible, mutations associated with CNS metastasis are easier to elucidate. The aims of this case series and systematic literature review are to describe the patient population with CNS metastatic disease from a gynecologic primary, and to investigate why the proportion of CNS metastasis from gynecologic malignancies is increasing. Ultimately, we hope to improve understanding of this subset of metastatic CNS malignancies and improve management strategies. Methods A literature review of articles describing patients from 1990–2020 who were diagnosed with CNS metastasis from a known gynecologic primary malignancy was performed. Demographics, cancer type, mutation characteristics, management for metastatic disease, progression free survival, number of CNS metastases, and location of metastatic disease were assessed. Inclusion criteria were age>18 years, diagnosis of primary ovarian, uterine, or cervical cancer with confirmed metastatic disease to the CNS, including brain parenchyma, leptomeninges, or intradural spinal cord or dural metastases. Exclusion criteria included pediatric population and bony metastases (e.g., bony spine metastases without evidence of meningeal/parenchymal invasion). Results Our review showed that patients with gynecological metastasis to the CNS generally have worse outcomes regarding overall survival, progression free survival, and quality of life than patients without CNS metastasis. Discussion Our results infer that the reported increase in incidence of CNS metastasis from gynecologic malignancies is a reflection of improvement of detection given advances in technology, improved patient follow up, and increased overall survival of patients with gynecologic malignancies. Further characterization of mutations from gynecologic malignancies associated with brain metastasis could result in development of more treatment options for patients in the future and help determine factors that contribute to developing metastasis to the CNS of various degrees, thus, potentially inform treatment strategies.

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Dong, Xiaomin, Yanan You, and Jia Qian Wu. "Building an RNA Sequencing Transcriptome of the Central Nervous System." Neuroscientist 22, no. 6 (July 7, 2016): 579–92. http://dx.doi.org/10.1177/1073858415610541.

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The composition and function of the central nervous system (CNS) is extremely complex. In addition to hundreds of subtypes of neurons, other cell types, including glia (astrocytes, oligodendrocytes, and microglia) and vascular cells (endothelial cells and pericytes) also play important roles in CNS function. Such heterogeneity makes the study of gene transcription in CNS challenging. Transcriptomic studies, namely the analyses of the expression levels and structures of all genes, are essential for interpreting the functional elements and understanding the molecular constituents of the CNS. Microarray has been a predominant method for large-scale gene expression profiling in the past. However, RNA-sequencing (RNA-Seq) technology developed in recent years has many advantages over microarrays, and has enabled building more quantitative, accurate, and comprehensive transcriptomes of the CNS and other systems. The discovery of novel genes, diverse alternative splicing events, and noncoding RNAs has remarkably expanded the complexity of gene expression profiles and will help us to understand intricate neural circuits. Here, we discuss the procedures and advantages of RNA-Seq technology in mammalian CNS transcriptome construction, and review the approaches of sample collection as well as recent progress in building RNA-Seq-based transcriptomes from tissue samples and specific cell types.

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Li, Yun Feng. "Sustainable Manufacturing Technology and Properties of Steel Slag Concrete." Advanced Materials Research 97-101 (March 2010): 901–4. http://dx.doi.org/10.4028/www.scientific.net/amr.97-101.901.

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Early-age deterioration of concrete due to cracking and higher maintenance cost for poor durability cause serious troubles to concrete structures. Steel slag is a solid waste discharged in large quantities by the iron and steel industry. Steel slag includes a certain scale mineral such as C2S and C3S, and can be applied in cement and concrete as mineral admixtures. When mineral admixtures with steel slag powder and blast-furnace slag powder are mixed into concrete, the performance of concrete can be improved further. Mineral admixtures with steel slag powder as partial replacement for Portland cement in mortar is an effective means for enhancing abrasion resistance. Steel slag powder can be used to reduce cracking in concrete at early age, so that it will improve the durability of concrete structures.

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MURAI, Shigeo, and Yuichi FUJIOKA. "Challenge to CCS Technology." Journal of The Institute of Electrical Engineers of Japan 127, no. 4 (2007): 242–45. http://dx.doi.org/10.1541/ieejjournal.127.242.

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Dilshad, M., and LJ Peel. "Evaluation of the USDA curve number method for agricultural catchments in the Australian semi-arid tropics." Soil Research 32, no. 4 (1994): 673. http://dx.doi.org/10.1071/sr9940673.

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The USDA-SCS curve number method (5 day antecedent rainfall version) was evaluated using rainfall and runoff data from four catchments at the Douglas-Daly Research Farm, 250 km S.W. of Darwin. These catchments were rotational cropped with maize and soybeans using either conventional or no-till technology. Optimized curve numbers (CNs) were calculated for each catchment and crop type for the various 5 day antecedent rainfall conditions (ARC) by using a grid-based statistical technique known as the Marquardt-Levenberg method. Significance levels (SL) of 0.05 or less were regarded as significant throughout. The curve number method (CNM) was able to describe significant levels of variation in observed rainfall and runoff data. By using optimized curve numbers, the CNM significantly explained up to 98% of the variation in data. Results showed that crop type and soil conservation bank spacing as individual factors had minor or no effect on optimized CNs, and hence on the ability of the CNM to predict runoff. Cropping technology and ARC, however, had a very strong influence on optimized CNs. Optimized CNs obtained in this study provide best estimates of CNs for use on commercial cropping catchments in the region.

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Han, Guansheng, Fei Xiong, Yu Zhou, Leibo Song, and Xingkai Wang. "Research Progress on Shear Characteristics of Rock Joints under Constant Normal Stiffness Boundary Conditions." Shock and Vibration 2021 (September 1, 2021): 1–6. http://dx.doi.org/10.1155/2021/9670151.

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The constant normal stiffness (CNS) boundary condition is more representative for the underground engineering, in which the shear-induced dilation is restricted by surrounding rocks, resulting in an increase in the normal stress. Therefore, the use of CNS boundary conditions in the research of shear-slip failure of underground rock engineering is more in line with the actual situation. Taking the instability and failure of surrounding rock in underground engineering as the background, the present study introduces the engineering background of CNS boundary conditions and the research progress on shear characteristics of rock joints under CNS boundary conditions. Three key directions for future research are proposed based on the latest research results of shear characteristics of rock joint under CNS boundary conditions: ① developing a rock joint shear test system that can realize the function of “CNS boundary conditions + shear-seepage test + visualization”; ② carrying out the shear tests of real rock joints under CNS boundary conditions based on 3D scanning and 3D carving technology; and ③ carrying out the shear tests of rock joint network under CNS boundary conditions.

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Susarla, Sridhar, Shigeki Masunaga, and Yoshitaka Yonezawa. "Reductive dechlorination pathways of chloro organics under anaerobic conditions." Water Science and Technology 34, no. 5-6 (September 1, 1996): 489–94. http://dx.doi.org/10.2166/wst.1996.0587.

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The transformation pathways of chloroanilines (CAs), chlorobenzenes (CBs) and chlorophenols (CPs) were examined in anaerobic sediment collected from the Tsurumi river, Japan. The sediment was pre-exposed to various organic chemicals from the surrounding industries and appears to be sulfidogenic. Experiments were carried out for each compound in the sediment slurry, which was spiked at a desired concentration. The transformation of the parent substrate and the appearance of its metabolites were monitored for a year. All the compounds transformed without any lag period. For CBs, the preferential Cl removal was in the order: two Cl atoms on adjacent carbon atoms > one Cl atom on adjacent carbon > no adjacent Cl atom on the carbon. In case of CPs, ortho dechlorination was the preferred pathway, while for CAs, sequential removal of ortho and para positions was observed.

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Saxena, Shailendra K., Sneham Tiwari, and Madhavan PN Nair. "Nanotherapeutics: emerging competent technology in neuroAIDS and CNS drug delivery." Nanomedicine 7, no. 7 (July 2012): 941–44. http://dx.doi.org/10.2217/nnm.12.63.

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Visted, Therese, Rolf Bjerkvig, and Per Øyvind Enger. "Cell encapsulation technology as a therapeutic strategy for CNS malignancies." Neuro-Oncology 3, no. 3 (July 1, 2001): 201–10. http://dx.doi.org/10.1093/neuonc/3.3.201.

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Visted, T. "Cell encapsulation technology as a therapeutic strategy for CNS malignancies." Neuro-Oncology 3, no. 3 (July 1, 2001): 201–10. http://dx.doi.org/10.1215/15228517-3-3-201.

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Omta, Onno, Jacques Trienekens, and George Beers. "The knowledge domain of chain and network science." Journal on Chain and Network Science 1, no. 2 (December 1, 2001): 77–85. http://dx.doi.org/10.3920/jcns2001.x007.

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This editorial paper aims to provide a framework to categorise and evaluate the domain of Chain and Network Science (CNS), and to provide an envelope for the research and management agenda. The authors strongly feel that although considerable progress has been made over the past couple of years in the development of the CNS domain, a number of important and exciting challenges are still waiting to be tackled. This paper provides a definition of the object of study of CNS, its central problem area, the organisation and governance of chain and network co-operation, and the relationships between chain organisation and technology development, market dynamics, and the economy and society at large. It indicates relevant sources of knowledge among the various academic disciplines. It touches upon CNS problem solving by identifying areas for knowledge development and CNS tool construction.

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Smirniotopoulos, J. G. "4228 CNS trauma." Journal de Radiologie 87, no. 10 (October 2006): 1180. http://dx.doi.org/10.1016/s0221-0363(06)86636-9.

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Mirkov, Gligorije, Zoran Bakić, and Mirko Đapić. "RFID technology in the service of flexible CNC programming." IMK-14 - Istrazivanje i razvoj 25, no. 4 (2019): 31–41. http://dx.doi.org/10.5937/imk1902031m.

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SUZUKI, Tsunehisa, Hiroshi SAITO, Toshiaki MITSUI, Mutsuto KATO, Tomoki FUJINO, and Yasufumi SATAKE. "E14 Machining ability of electroplated diamond tools with CNT-coated diamond grains(Grinding technology)." Proceedings of International Conference on Leading Edge Manufacturing in 21st century : LEM21 2009.5 (2009): 553–57. http://dx.doi.org/10.1299/jsmelem.2009.5.553.

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Desroches, B. R., P. Zhang, B. R. Choi, M. E. King, A. E. Maldonado, W. Li, A. Rago, et al. "Functional scaffold-free 3-D cardiac microtissues: a novel model for the investigation of heart cells." American Journal of Physiology-Heart and Circulatory Physiology 302, no. 10 (May 15, 2012): H2031—H2042. http://dx.doi.org/10.1152/ajpheart.00743.2011.

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To bridge the gap between two-dimensional cell culture and tissue, various three-dimensional (3-D) cell culture approaches have been developed for the investigation of cardiac myocytes (CMs) and cardiac fibroblasts (CFs). However, several limitations still exist. This study was designed to develop a cardiac 3-D culture model with a scaffold-free technology that can easily and inexpensively generate large numbers of microtissues with cellular distribution and functional behavior similar to cardiac tissue. Using micromolded nonadhesive agarose hydrogels containing 822 concave recesses (800 μm deep × 400 μm wide), we demonstrated that neonatal rat ventricular CMs and CFs alone or in combination self-assembled into viable (Live/Dead stain) spherical-shaped microtissues. Importantly, when seeded simultaneously or sequentially, CMs and CFs self-sorted to be interspersed, reminiscent of their myocardial distribution, as shown by cell type-specific CellTracker or antibody labeling. Microelectrode recordings and optical mapping revealed characteristic triangular action potentials (APs) with a resting membrane potential of −66 ± 7 mV ( n = 4) in spontaneously contracting CM microtissues. Under pacing, optically mapped AP duration at 90% repolarization and conduction velocity were 100 ± 30 ms and 18.0 ± 1.9 cm/s, respectively ( n = 5 each). The presence of CFs led to a twofold AP prolongation in heterogenous microtissues (CM-to-CF ratio of 1:1). Importantly, Ba2+-sensitive inward rectifier K+ currents and Ca2+-handling proteins, including sarco(endo)plasmic reticulum Ca2+-ATPase 2a, were detected in CM-containing microtissues. Furthermore, cell type-specific adenoviral gene transfer was achieved, with no impact on microtissue formation or cell viability. In conclusion, we developed a novel scaffold-free cardiac 3-D culture model with several advancements for the investigation of CM and CF function and cross-regulation.

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Fortin, David. "Drug Delivery Technology to the CNS in the Treatment of Brain Tumors: The Sherbrooke Experience." Pharmaceutics 11, no. 5 (May 27, 2019): 248. http://dx.doi.org/10.3390/pharmaceutics11050248.

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Drug delivery to the central nervous system (CNS) remains a challenge in neuro-oncology. Despite decades of research in this field, no consensus has emerged as to the best approach to tackle this physiological limitation. Moreover, the relevance of doing so is still sometimes questioned in the community. In this paper, we present our experience with CNS delivery strategies that have been developed in the laboratory and have made their way to the clinic in a continuum of translational research. Using the intra-arterial (IA) route as an avenue to deliver chemotherapeutics in the treatment of brain tumors, complemented by an osmotic breach of the blood-brain barrier (BBB) in specific situations, we have developed over the years a comprehensive research effort on this specialized topic. Looking at pre-clinical work supporting the rationale for this approach, and presenting results discussing the safety of the strategy, as well as results obtained in the treatment of malignant gliomas and primary CNS lymphomas, this paper intends to comprehensively summarize our work in this field.

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Baisden, Joseph M., Stanley H. Benedict, Ke Sheng, Paul W. Read, and James M. Larner. "Helical TomoTherapy in the treatment of central nervous system metastasis." Neurosurgical Focus 22, no. 3 (March 2007): 1–6. http://dx.doi.org/10.3171/foc.2007.22.3.9.

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✓In this report the authors review the use of radiotherapy in the treatment of central nervous system (CNS) metastasis. They comment on different treatment methods for both intracranial and extracranial CNS metastasis and discuss some of the evidence supporting the use of radiotherapy in these settings. Recent advancements in radiation oncology technology are briefly reviewed with a focus on the advantages and disadvantages of helical TomoTherapy–based treatment strategies. A review of pertinent current literature was performed. TomoTherapy research currently underway at the University of Virginia Health System is discussed and a representative case is presented. Radiotherapy for CNS metastasis is an effective treatment that provides palliation of symptoms and confers a survival advantage on selected patients. Advances in radiotherapy techniques continue to improve the therapeutic ratio for patients with CNS metastases. Helical TomoTherapy offers distinct advantages for patients with CNS metastatic disease by sparing normal tissue when intracranial or extracranial disease is targeted.

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Mikhael, Neveen L., Myriam Abo Seif H Gendi, Hoda Hassab, and Elshaymaa A. Megahed. "Evaluation of multiplexed biomarkers in assessment of CSF infiltration in pediatric acute lymphoblastic leukemia." International Journal of Hematologic Oncology 8, no. 3 (November 1, 2019): IJH22. http://dx.doi.org/10.2217/ijh-2019-0008.

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Acute lymphoblastic leukemia (ALL) is a very common pediatric malignancy with high survival rates. The course of treatment is modified according to the occurrence of central nervous system (CNS) disease. Aim: To relate serum and cerebrospinal fluid levels of five biomarkers (matrix metalloprotienase 9, CCL-2, sVCAM-1, IFN-γ and inducible protein 10) at diagnosis to the development of CNS infiltration. Methods: The present study was carried on 64 children with ALL and 20 controls. Multiplexed cytokines were measured by Luminex technology (Matrix metalloprotienase 9, CCL-2, sVCAM-1, IFN-γ and inducible protein 10). Results: Significantly higher sMMP-9 and lower sCCL2 were found in patients who developed CNS leukemia. Conclusion: Serum multiplexed parameters at diagnosis of childhood ALL may predict of development of CNS leukemia.

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Sim, Tao Ming, Dinesh Tarini, S. Thameem Dheen, Boon Huat Bay, and Dinesh Kumar Srinivasan. "Nanoparticle-Based Technology Approaches to the Management of Neurological Disorders." International Journal of Molecular Sciences 21, no. 17 (August 23, 2020): 6070. http://dx.doi.org/10.3390/ijms21176070.

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Neurological disorders are the most devastating and challenging diseases associated with the central nervous system (CNS). The blood-brain barrier (BBB) maintains homeostasis of the brain and contributes towards the maintenance of a very delicate microenvironment, impairing the transport of many therapeutics into the CNS and making the management of common neurological disorders such as Alzheimer’s disease (AD), Parkinson’s disease (PD), cerebrovascular diseases (CVDs) and traumatic brain injury (TBI), exceptionally complicated. Nanoparticle (NP) technology offers a platform for the design of tissue-specific drug carrying systems owing to its versatile and modifiable nature. The prospect of being able to design NPs capable of successfully crossing the BBB, and maintaining a high drug bioavailability in neural parenchyma, has spurred much interest in the field of nanomedicine. NPs, which also come in an array of forms including polymeric NPs, solid lipid nanoparticles (SLNs), quantum dots and liposomes, have the flexibility of being conjugated with various macromolecules, such as surfactants to confer the physical or chemical property desired. These nanodelivery strategies represent potential novel and minimally invasive approaches to the treatment and diagnosis of these neurological disorders. Most of the strategies revolve around the ability of the NPs to cross the BBB via various influx mechanisms, such as adsorptive-mediated transcytosis (AMT) and receptor-mediated transcytosis (RMT), targeting specific biomarkers or lesions unique to that pathological condition, thereby ensuring high tissue-specific targeting and minimizing off-target side effects. In this article, insights into common neurological disorders and challenges of delivering CNS drugs due to the presence of BBB is provided, before an in-depth review of nanoparticle-based theranostic strategies.

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Becher, Mark W. "Practical Neuropathology Synoptic Reporting for Central Nervous System Tumors." Archives of Pathology & Laboratory Medicine 135, no. 6 (June 1, 2011): 789–92. http://dx.doi.org/10.5858/2010-0193-ra.1.

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AbstractContext.—Synoptic reporting for central nervous system (CNS) tumors has never been formally addressed, and neuropathologists lack practical templates that they can adapt to their laboratory information system to be compliant with College of American Pathologists (CAP) standards.Objectives.—To provide practical synoptic report templates designed for CNS tumors that allow for easy data extraction and CAP compliance and improve the reporting of CNS tumors.Data Sources.—Review of literature and synoptic report format experience in our practice.Conclusions.—Synoptic reporting of required elements is a recently introduced standard for CNS tumors. It is difficult to use a universal non-CNS tumor synoptic report template for CNS tumors because they are heavily weighted to include items not important or required for CNS tumors, such as margins and the TNM classification system. In addition, the CAP CNS protocol, published in 2008, is an immense comprehensive document that is not conducive to simple inclusion in a narrative report. We describe our experience using a synoptic template for CNS tumors that includes all required elements, is tailored to the practice of neuropathology, and can easily be adapted to other laboratory information systems. Because of the multidisciplinary nature of CNS tumor diagnoses, neuropathologists typically collect clinical, demographic, and imaging data on all CNS tumor cases. These data can readily be entered into a primary synoptic report that could replace our standard narrative report.

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Belleville, Arnaud, Federico Garavaglia, Damien Sevrez, Véronique Mary, Aloïs Tilloy, Didier Scopel, and Hélène Combes. "Réanalyse des chroniques patrimoniales de débit. Évaluation de l'impact et valorisation." La Houille Blanche, no. 5-6 (October 2018): 29–35. http://dx.doi.org/10.1051/lhb/2018048.

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L'archivage d'une série de débit en base de données à l'issue d'une phase de validation et de critique est souvent considéré par l'hydromètre comme l'étape finale du processus de production de données. Cependant, lors de la valorisation ultérieure de ces données dans le cadre d'études hydrologiques, de nouveaux éléments de connaissance relatifs à la station hydrométrique (jaugeages haut débit, modélisation hydraulique, etc.) peuvent être disponibles et conduire à se réinterroger sur la nécessité d'actualiser le calcul des débits via la mise à jour des courbes de tarage. De même, une mise en perspective historique des différentes pratiques des producteurs de données met en évidence une hétérogénéité dans le processus d'élaboration des données. La présente communication propose une méthodologie pour réanalyser les chroniques patrimoniales de débit, de manière à proposer des séries homogènes et moins biaisées. Cette méthodologie est ensuite appliquée à un échantillon de 60 stations hydrométriques. Il ressort de cette étude qu'aucune tendance nette n'est mise en évidence sur les écarts en volume et en crue entre les séries réanalysées et les séries historiques, mais des corrections peuvent néanmoins être sensibles dans certains cas. Un cas d'application est enfin détaillé pour mettre en évidence les impacts potentiels de la réanalyse des chroniques de débit sur la détermination des débits extrêmes. En perspectives, une réflexion peut être menée sur le rôle du producteur de données vis-à-vis de l'hydrologue utilisant ces données, sur l'intérêt d'inscrire ces réanalyses de chroniques dans une démarche pérenne et systématique. La question de la valorisation et la traçabilité de telles études est également posée.

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朱, 海. "Study on High-Precision Horizontal Reference Construction Technology of INS/CNS." Dynamical Systems and Control 09, no. 04 (2020): 196–206. http://dx.doi.org/10.12677/dsc.2020.94019.

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Zhao, Wangyang, Gaoling Song, Lingfeng Zhou, Kai Wang, and Juzhong Liu. "Study on Shafting Calibration Technology of INS/CNS Integrated Navigation System." IOP Conference Series: Materials Science and Engineering 768 (March 31, 2020): 042012. http://dx.doi.org/10.1088/1757-899x/768/4/042012.

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Vargas-Toscano, Andres, Dilaware Khan, Ann-Christin Nickel, Michael Hewera, Marcel Alexander Kamp, Igor Fischer, Hans-Jakob Steiger, et al. "Robot technology identifies a Parkinsonian therapeutics repurpose to target stem cells of glioblastoma." CNS Oncology 9, no. 2 (June 2020): CNS58. http://dx.doi.org/10.2217/cns-2020-0004.

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Aim: Glioblastoma is a heterogeneous lethal disease, regulated by a stem-cell hierarchy and the neurotransmitter microenvironment. The identification of chemotherapies targeting individual cancer stem cells is a clinical need. Methodology: A robotic workstation was programmed to perform a drug concentration to cell-growth analysis on an in vitro model of glioblastoma stem cells (GSCs). Mode-of-action analysis of the selected top substance was performed with manual repetition assays and acquisition of further parameters. Results: We identified 22 therapeutic potential substances. Three suggested a repurpose potential of neurotransmitter signal-modulating agents to target GSCs, out of which the Parkinson's therapeutic trihexyphenidyl was most effective. Manual repetition assays and initial mode of action characterization revealed suppression of cell proliferation, cell cycle and survival. Conclusion: Anti-neurotransmitter signaling directed therapy has potential to target GSCs. We established a drug testing facility that is able to define a mid-scale chemo responsome of in vitro cancer models, possibly also suitable for other cell systems.

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Leggiero, Nicole, Terri Armstrong, Elizabeth Vera, Mark Gilbert, and Amanda King. "QOLP-28. THE USE OF VIRTUAL REALITY FOR SYMPTOM MANAGEMENT: APPLICATION IN NEURO-ONCOLOGY." Neuro-Oncology 21, Supplement_6 (November 2019): vi203—vi204. http://dx.doi.org/10.1093/neuonc/noz175.848.

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Abstract Patients with primary central nervous system (CNS) tumors are highly symptomatic due to the functional sequelae of their disease and an unfavorable prognosis. Virtual reality (VR) immersive technology has demonstrated benefit in improving patients’ symptom burden, such as distress, pain, anxiety, and fatigue. However, this has not been explored in a CNS tumor population. This project explored the potential use of VR for symptom management in CNS tumor patients. A descriptive analysis of MDASI-BT/MDASI-SP/PROMIS-Anxiety patient-reported outcomes (PROs) for 535 CNS tumor patients was performed to identify the common moderate-severe (> 4 on a 0–10 scale) symptoms. Additionally, a systematic review of literature was performed addressing the question “For adult patients with solid tumors, what effect does VR have on their self-reported symptoms, such as distress, anxiety and pain?” The systematic literature review resulted in 17 studies using VR in other solid tumor populations, which demonstrated improvement in pain, anxiety, and distress. However, study designs often lacked rigor and none incorporated any biomarkers to correlate with PROs. CNS tumor symptom review of our patient cohort revealed that the majority of the patients were Caucasian (83%) males (58%) with a median age of 50 years (range, 18–83). At the time of diagnosis, 35% had a gross total resection. Glioblastoma was the most common diagnosis (32%) and 50% had a high-grade glioma. The most prevalent moderate-severe symptoms in this sample was fatigue (34%), with (14%) anxiety, (18%) pain, and (19%) distress. Given the high symptom rate in our patients, the promising but limited data that VR technology could improve distress and other symptoms provides strong support for this intervention in the CNS tumor population. Further research is needed to assess feasibility and efficacy of VR, as well as incorporation of correlative biomarkers, to better determine potential improvement in patient symptom burden.

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Lonser, Russell R., Malisa Sarntinoranont, Paul F. Morrison, and Edward H. Oldfield. "Convection-enhanced delivery to the central nervous system." Journal of Neurosurgery 122, no. 3 (March 2015): 697–706. http://dx.doi.org/10.3171/2014.10.jns14229.

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Convection-enhanced delivery (CED) is a bulk flow–driven process. Its properties permit direct, homogeneous, targeted perfusion of CNS regions with putative therapeutics while bypassing the blood-brain barrier. Development of surrogate imaging tracers that are co-infused during drug delivery now permit accurate, noninvasive real-time tracking of convective infusate flow in nervous system tissues. The potential advantages of CED in the CNS over other currently available drug delivery techniques, including systemic delivery, intrathecal and/or intraventricular distribution, and polymer implantation, have led to its application in research studies and clinical trials. The authors review the biophysical principles of convective flow and the technology, properties, and clinical applications of convective delivery in the CNS.

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Fujiki, Kenji, and Mélanie Laleau. "Une approche géographique pour spatialiser les besoins en hébergements d'urgence en situation de crise : une étude appliquée au cas d'une évacuation massive provoquée par une crue majeure de la seine en région francilienne." La Houille Blanche, no. 3-4 (October 2019): 75–83. http://dx.doi.org/10.1051/lhb/2019043.

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Avec jusqu'à 1 million de personnes inondées, et 6,5 millions d'habitants privés d'eau ou d'électricité, les autorités régionales s'interrogent sur la capacité à mener à bien une évacuation de l'agglomération francilienne en cas de crue exceptionnelle de la Seine. L'étude présentée ici vise à répondre à une partie de ces interrogations, en proposant un outil d'aide à la décision sous SIG pour identifier de façon spatialisée les besoins de prise en charge dans l'hébergement d'urgence des populations sinistrées, en cas d'évacuation massive. La méthodologie se fonde sur la combinaison de deux indices, agrégés à l'échelle du bâti : (1) un « indice d'exposition », qui synthétise des variables relatives à l'aléa et aux impacts physiques induits par ce dernier. Cet indice est constitué à partir d'une réflexion sur la stratégie d'évacuation envisagée par la Préfecture de Police, coordinatrice de la gestion de crise à l'échelle régionale ; (2) un « indice de susceptibilité à l'auto-hébergement », qui vise à représenter la capacité d'une population donnée à trouver un hébergement par ses propres moyens, chez des proches notamment, en synthétisant diverses variables sociales et démographiques. Ces variables sont identifiées grâce à un état de l'art ad hoc, constitué à partir de retours d'expérience internationaux d'évacuations massives passées.

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Gregory, Debbie, and Martha Buckner. "Point-of-Care Technology." Critical Care Nursing Quarterly 37, no. 3 (2014): 268–72. http://dx.doi.org/10.1097/cnq.0000000000000030.

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Quail, M. Thomas. "Technology in Health Care." Critical Care Nursing Quarterly 38, no. 1 (2015): 49–80. http://dx.doi.org/10.1097/cnq.0000000000000049.

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Buckner, Martha, and Debbie D. Gregory. "Point-of-Care Technology." Critical Care Nursing Quarterly 34, no. 4 (2011): 297–305. http://dx.doi.org/10.1097/cnq.0b013e31822bac0e.

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Lee, Ung-Jae, Kyung-Sil Shim, Ju-Yong Jung, and Tae-Min Kim. "A Trend of Catalyst Technology for After treatment on H2-CNG Mixed Fuel Vehicles." Journal of the Korean Institute of Gas 15, no. 2 (April 30, 2011): 21–26. http://dx.doi.org/10.7842/kigas.2011.15.2.021.

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Roberts, Mitchell, Orli Kehat, Michaela Gross, Nethanel Lasri, Gil Issachar, Erica Sappington VandeWeerd, Ziv Peremen, and Amir Geva. "TECHNOLOGY TRANSLATING THE RELATIONSHIP BETWEEN QUALITY OF LIFE AND MEMORY USING A NOVEL EEG TECHNOLOGY." Innovation in Aging 3, Supplement_1 (November 2019): S331—S332. http://dx.doi.org/10.1093/geroni/igz038.1207.

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Abstract Existing research has postulated a relationship between cognition and quality of life (QoL). Components of QoL such as satisfaction with social support may be particularly influential in memory for those with comorbidities. Additional research is needed to characterize the relationship between memory and QoL domains. Findings are presented from a clinical trial using BNA memory scores to assess brain health. BNA uses EEG technology and machine learning to map networks of brain functioning including working memory. Participants were older adults living in The Villages, an active lifestyle community in Florida, between the ages of 55-85, from 8/30/2017-3/11/2019. Participants were stratified into 2 groups: healthy (no CNS/psychiatric conditions; n=158) and multi-morbid (>1 CNS and/or psychiatric conditions; n=106) and compared across memory and QoL indicators. Subjective QoL was measured by the WHOQOL-BREF across 4 domains (physical, psychological, social, environmental). Scores on QoL domains were divided into 3 levels (high-medium-low) and tested for their relationship to BNA memory scores using ANOVA. Results indicate a relationship between health status, subjective QoL and BNA memory scores. Healthy subjects who scored high in the psychological QoL domain had significantly higher memory scores [F(2,152)=4.30,p=.02)]. In healthy subjects, satisfaction with social support (p=.001) had the strongest impact on memory for social QoL, while body image (p=.06) and concentration (p=.06) were the most salient predictors of psychological QoL and approached significance. Multi-morbid subjects who indicated high social ratings had higher memory scores (F(2,100)=3.75,p=.03) which relied heavily on satisfaction with social support (p=.003). Implications for policy and practice are discussed.

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Huh, Cheol, Seong-Gil Kang, Keum-Suk Lee, and Young-Gyu Park. "Offshore CCS Plant Technology for 3Mt-CO₂ Storage." Transactions of the KSME C: Industrial Technology and Innovation 1, no. 1 (July 1, 2013): 123–28. http://dx.doi.org/10.3795/ksme-c.2013.1.1.123.

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Tadić, Staša. "CNS and bladder (short review for clinicians)." Acta Facultatis Medicae Naissensis 31, no. 1 (March 1, 2014): 5–16. http://dx.doi.org/10.2478/afmnai-2014-0001.

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SUMMARY Symptoms of bladder dysfunction are significant public health problem due to their prevalence, morbidity and treatment costs. Most stem from bladder control problem which is governed by the brain, yet we know little about CNS and bladder. Advances in brain imaging technology have brought new insight in how brain works in different bladder diseases and opened new possibilities to study lower urinary tract. Thus, it is important for urologists and clinicians alike to get informed about basic concepts of brain-bladder control. The aim of this article is to review basic neuroanatomy of central continence control based on the results of recent brain imaging studies in patients with symptoms of impaired bladder control.

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Celie, Sabrina, Guillaume Bontron, David Ouf, and Evelyne Pont. "Apport de l'expertise dans la prévision hydro-météorologique opérationnelle." La Houille Blanche, no. 2 (April 2019): 55–62. http://dx.doi.org/10.1051/lhb/2019015.

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CNR, premier producteur français d'électricité d'origine 100 % renouvelable, a aménagé et exploite le Rhône le long de sa partie française. En tant que concessionnaire, CNR est en charge de plusieurs missions telles que la navigation et la production d'électricité. Pour mener à bien ces responsabilités, CNR a développé une chaîne d'outils opérationnelle réalisant les prévisions au niveau de différents aménagements du Rhône. En complément de ces outils informatiques, des prévisionnistes hydro-météorologues analysent les sorties des modèles météorologiques et hydrologiques, expertisent les résultats et affinent les prévisions. Cette communication présente comment une expertise hydro-météorologique peut compléter et enrichir une chaîne de prévision opérationnelle et met en avant les gains que cette expertise peut apporter sur la qualité des prévisions. Actuellement, la chaîne opérationnelle repose sur des prévisions déterministes, mais CNR qui a besoin d'affiner ces prévisions et d'en évaluer la fiabilité est en train de développer une chaîne de prévisions probabilistes. Ce papier montre que l'apport de l'expertise est indéniable pour ajouter de la plus-value à des modèles déterministes, mais cela sera-t-il toujours le cas dans un contexte probabiliste ?

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Journal articles on the topic 'Technológa CNS'

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