Journal articles on the topic 'Teeth Dental therapeutics'

Sclerostin modulation is a novel therapeutic bone regulation strategy. The anti-sclerostin drugs, proposed in medicine for skeletal bone loss may be developed for jaw bone indications in dentistry. Alveolar bone responsible for housing dentition share common bone remodeling mechanisms with skeletal bone. Manipulating alveolar bone turnover can be used as a strategy to treat diseases such as periodontitis, where large bone defects from disease are a surgical treatment challenge and to control tooth position in orthodontic treatment, where moving teeth through bone in the treatment goal. Developing such therapeutics for dentistry is a future line for research and therapy. Furthermore, it underscores the interprofessional relationship that is the future of healthcare.

The mesenchymal stem cells of dental pulp (DPSCs) were isolated and characterized for the first time more than a decade ago as highly clonogenic cells that were able to generate densely calcified colonies. Now, DPSCs are considered to have potential as stem cell source for orthopedic and oral maxillofacial reconstruction, and it has been suggested that they may have applications beyond the scope of the stomatognathic system. To date, most studies have shown that, regardless of their origin in third molars, incisors, or exfoliated deciduous teeth, DPSCs can generate mineralized tissue, an extracellular matrix and structures type dentin, periodontal ligament, and dental pulp, as well as other structures. Different groups worldwide have designed and evaluated new efficient protocols for the isolation, expansion, and maintenance of clinically safe human DPSCs in sufficient numbers for various therapeutics protocols and have discussed the most appropriate route of administration, the possible contraindications to their clinical use, and the parameters to be considered for monitoring their clinical efficacy and proper biological source. At present, DPSC-based therapy is promising but because most of the available evidence was obtained using nonhuman xenotransplants, it is not a mature technology.

In Lake Malawi cichlids, each tooth is replaced in one-for-one fashion every ∼20 to 50 d, and taste buds (TBs) are continuously renewed as in mammals. These structures are colocalized in the fish mouth and throat, from the point of initiation through adulthood. Here, we found that replacement teeth (RT) share a continuous band of epithelium with adjacent TBs and that both organs coexpress stem cell factors in subsets of label-retaining cells. We used RNA-seq to characterize transcriptomes of RT germs and TB-bearing oral epithelium. Analysis revealed differential usage of developmental pathways in RT compared to TB oral epithelia, as well as a repertoire of genome paralogues expressed complimentarily in each organ. Notably, BMP ligands were expressed in RT but excluded from TBs. Morphant fishes bathed in a BMP chemical antagonist exhibited RT with abrogated shh expression in the inner dental epithelium (IDE) and ectopic expression of calb2 (a TB marker) in these very cells. In the mouse, teeth are located on the jaw margin while TBs and other oral papillae are located on the tongue. Previous study reported that tongue intermolar eminence (IE) oral papillae of Follistatin (a BMP antagonist) mouse mutants exhibited dysmorphic invagination. We used these mutants to demonstrate altered transcriptomes and ectopic expression of dental markers in tongue IE. Our results suggest that vertebrate oral epithelium retains inherent plasticity to form tooth and taste-like cell types, mediated by BMP specification of progenitor cells. These findings indicate underappreciated epithelial cell populations with promising potential in bioengineering and dental therapeutics.

This paper reviewed of bruxism phenomenon that refers to the grinding or clenching of the teeth during awake ornight sleep. The prevalence of bruxism decreases with age from 14-18% in childhood, 8% of adult population and3% in the elderly. According to the existing literature, two groups of proposed etiological factors can bedistinguished: peripheral (morphological) and central (pathophysiological and psychological). At present, thebruxism is more often thought to be regulated centrally, not peripherally. Signs and symptoms of bruxism such astooth wear/dental attrition, abfractions, orofacial pain, change of periodontal ligament, mobility, tooth sensitivity,fractured teeth and fillings, earache, headache, tightness of jaw muscle, chewed tissue on the inside of your cheek,impact on the esthetic appearance of a smile. There have been many clinical approaches to the treatment ofbruxism. These can be categorized as acute, preventive and chronic management of bruxism, based on patient’ssigns and symptoms. In the case of acute symptoms with patients experiencing pain, pharmaco-therapeutics may berequired. Meanwhile, if tooth wear is present an occlusal splint and stress management are recommended. Dentistsand health professionals should be aware of increasing the phenomenon of bruxism.

Abstract Background In 2016, an Orange County, California, pediatric dental clinic’s contaminated water system led to the largest outbreak of odontogenic NTM infections yet described. Methods Mandatory reporting and active case finding directed by County Public Health were conducted in collaboration with community Pediatric Infectious Disease physicians for patients who underwent pulpotomy at Dental Clinic A from January 1 to September 6, 2016. Confirmed cases were those with positive NTM culture. Probable cases were those with multiple pulmonary nodules on computed tomography (CT), necrotic bone or osteomyelitis seen at surgery, or pathology with positive acid-fast bacilli stain, granulomatous inflammation or chronic osteomyelitis. Clinical data was collected from medical records. Results Of 1,089 patients at risk, 71 cases (22 (31%) confirmed and 49 (69%) probable) (Figure 1) had been identified as of March 19, 2018 (Figure 2). Median case age was 6 years (range 2–11 years). Symptoms began a median of 85 days (range 1–409 days) after pulpotomy (Figure 3). Pain and/or swelling on admission were reported in 79%; 21% were asymptomatic. CT findings included 49/70 with abnormalities of the mandible or maxilla, 13/70 with lymphadenopathy, and 19/68 with pulmonary nodules. Only 6/60 had erythrocyte sedimentation rate >40 mm/hour. Of 71 cases, 70 were hospitalized and underwent surgical debridement, for an average of 8.5 inpatient days (range 1–60 days); 23 had >1 hospitalization and 26 required >1 inpatient surgery. Permanent teeth were lost in 45/65 (range of 1–6 teeth lost). Intravenous antibiotics were administered to 32 cases for a median length of 137 days (range 113–282 days). Clofazimine was obtained for 29/32 cases as part of the regimen. Medical therapy was complicated by peripherally inserted central catheter malfunction/replacement/infection (18/27), rash (2/27), neutropenia (12/27), and elevated creatinine (7/27). All treated children showed evidence of jaw healing with resolved or improving lung nodules at 1-year follow-up. Conclusion This is the largest outbreak of invasive NTM infections seen associated with a pediatric dental practice. While infections were indolent, patients suffered medical and surgical consequences of treatment. Enhanced national dental water quality standards are needed to prevent future outbreaks. Disclosures A. Arrieta, Melinta Therapeutics: Investigator, Research support

The GH/IGF axis is a major regulator of bone formation and resorption and is essential to the achievement of normal skeleton growth and homeostasis. Beyond its key role in bone physiology, the GH/IGF axis has also major pleiotropic endocrine and autocrine/paracrine effects on mineralized tissues throughout life. This article aims to review the literature on GH, IGFs, IGF binding proteins, and their respective receptors in dental tissues, both epithelium (enamel) and mesenchyme (dentin, pulp, and tooth-supporting periodontium). The present review re-examines and refines the expression of the elements of the GH/IGF axis in oral tissues and their in vivo and in vitro mechanisms of action in different mineralizing cell types of the dento-alveolar complex including ameloblasts, odontoblasts, pulp cells, cementoblasts, periodontal ligament cells, and jaw osteoblasts focusing on cell-specific activities. Together, these data emphasize the determinant role of the GH/IGF axis in physiological and pathological development, morphometry, and aging of the teeth, the periodontium, and oral bones in humans, rodents, and other vertebrates. These advancements in oral biology have elicited an enormous interest among investigators to translate the fundamental discoveries on the GH/IGF axis into innovative strategies for targeted oral tissue therapies with local treatments, associated or not with materials, for orthodontics and the repair and regeneration of the dento-alveolar complex and oral bones.

Background: Periodontal disease is a chronic inflammatory condition that affects supporting tissues around teeth, resulting in periodontal tissue breakdown. If left untreated, periodontal disease could have serious consequences; this condition is in fact considered as the primary cause of tooth loss. Being highly prevalent among adults, periodontal disease treatment is receiving increased attention from researchers and clinicians. When this condition occurs around dental implants, the disease is termed peri-implantitis. Periodontal regeneration aims at restoring the destroyed attachment apparatus, in order to improve tooth stability and thus reduce disease progression and subsequent periodontal tissue breakdown. Although many biomaterials have been developed to promote periodontal regeneration, they still have their own set of disadvantages. As a result, regenerative medicine has been employed in the periodontal field, not only to overcome the drawbacks of the conventional biomaterials but also to ensure more predictable regenerative outcomes with minimal complications. Regenerative medicine is considered a part of the research field called tissue engineering/regenerative medicine (TE/RM), a translational field combining cell therapy, biomaterial, biomedical engineering and genetics all with the aim to replace and restore tissues or organs to their normal function using in vitro models for in vivo regeneration. In a tissue, cells are responding to different micro-environmental cues and signaling molecules, these biological factors influence cell differentiation, migration and cell responses. A central part of TE/RM therapy is introducing drugs, genetic materials or proteins to induce specific cellular responses in the cells at the site of tissue repair in order to enhance and improve tissue regeneration. In this review, we present the state of art of gene therapy in the applications of periodontal tissue and peri-implant regeneration. Purpose: We aim herein to review the currently available methods for gene therapy, which include the utilization of viral/non-viral vectors and how they might serve as therapeutic potentials in regenerative medicine for periodontal and peri-implant tissues.

AbstractThe objective of this study was to investigate the reproducibility of the International System for the Detection and Evaluation of Caries (ICDAS) for the diagnosis of caries by students of the Master's Degree in Dentistry (n = 25). The occlusal surfaces of human third molars (n = 14) were evaluated by twenty-five (n = 25) students using the ICDAS index and later a questionnaire was applied on demographic and professional context data. The dental crowns were sectioned in mesial to distal direction to obtain slices of 1mm in thickness which were observed in a stereomicroscope (40X) to identify the greatest extension of caries lesion. Data were analyzed by the Chi-Square, Fisher's Exact and Spearman's Correlation Coefficient at a significance level of 5%. There was an influence in the diagnosis of caries among students and teeth, where the majority of those who declared themselves to be safe missed the diagnosis. There was variability between the diagnosis and the proposed treatment for caries, with a better diagnosis for tooth VII and less for X; greater fit for treatment of teeth XIII, XIV and lower for IV, VI. The histological cut showed that the teeth were more affected by caries than the ICDAS. It was concluded that the ICDAS reproducibility was partially satisfactory when the occlusal surface was evaluated by the master’s degree students. Keywords: Dental Caries. Diagnostic Techniques and Procedures. Therapeutics. ResumoEste trabalho teve o objetivo de investigar a reprodutibilidade do Sistema Internacional de Detecção e Avaliação de Cárie (ICDAS) para o diagnóstico da cárie, por estudantes de curso de Mestrado em Odontologia (n=25). As superfícies oclusais de terceiros molares humanos (n=14) foram avaliadas por vinte e cinco (n=25) estudantes, utilizando o índice ICDAS, e posteriormente foi aplicado questionário sobre dados demográficos e de contexto profissional. As coroas dentárias foram seccionadas no sentido mésio distal para obter fatias de 1 mm de espessura, que foram observadas em estereomicroscópio (40X) para identificar a maior extensão da lesão de cárie. Os dados foram analisados pelos Testes Qui-Quadrado, Exato de Fisher e Coeficiente de Correlação de Spearman, em nível de significância de 5%. Houve influência do grau de instrução dos estudantes no diagnóstico da cárie em relação ao dente avaliado e a maioria que se declarou segura errou o diagnóstico. Houve variabilidade entre o diagnóstico e o tratamento proposto para a cárie, com maior acerto para diagnóstico do dente VII e menor para o X; maior acerto para tratamento dos dentes XIII, XIV e menor para IV, VI. O corte histológico mostrou que os dentes estavam mais comprometidos pela cárie que o ICDAS. Concluiu-se que a reprodutibilidade do ICDAS foi satisfatória quando a superfície oclusal foi avaliada pelos mestrandos. Palavras-chave: Cárie Dentária. Técnicas e Procedimentos Diagnósticos. Terapêutica.

Introduction. Dental impaction represents the group of isolated dental anomalies characterized by retention of a tooth with a fully formed root in the jaw bone, after the eruption period has passed. This anomaly may affect deciduous teeth, permanent or supernumerary teeth causing aesthetic and / or functional disorders. Case report. The case presents a clinical situation of a girl who presented two maxillary teeth impacted (a central incisor and a cuspid) who underwent surgical exposure and orthodontic treatment for their arch alignments. Conclusions. Impacted teeth may produce dental malpositions or root resorption of the adjacent teeth, cysts or chronic local infections, which carry out a surgical orthodontic treatment, complex and for a long term, depending on the clinical situation existing.

AbstractThis article review specific clinical issues of the molar teeth, as well as the therapeutic approach of their pathology. The dental pathology we face in the group of molars is related to: dental caries, dental trauma (crown and crown-root fractures), dental wear phenomena. The therapeutic approach of the molar teeth is represented by: restoration of the loss of hard dental tissues; endodontic treatments of pulpal and periapical complications; surgical treatment. The restorative treatments in molars are: direct restorations, with or without supplementary anchorage for obturations; inlay, onlay; prosthetic crown.

According to statistics, periodontal dental diseases caused by trauma interest annualy million patients worldwide. Periodontal dental injuries are medical emergencies, both by their acute, but also two important things to confer specificity: patient age and multidisciplinary therapeutic approach.

Stem cell biology has become an important field in regenerative medicine and tissue engineering therapy since the discovery and characterization of mesenchymal stem cells. Stem cell populations have also been isolated from human dental tissues, including dental pulp stem cells, stem cells from human exfoliated deciduous teeth, stem cells from apical papilla, dental follicle progenitor cells, and periodontal ligament stem cells. Dental stem cells are relatively easily obtainable and exhibit high plasticity and multipotential capabilities. The dental stem cells represent a gold standard for neural-crest-derived bone reconstruction in humans and can be used for the repair of body defects in low-risk autologous therapeutic strategies. The bioengineering technologies developed for tooth regeneration will make substantial contributions to understand the developmental process and will encourage future organ replacement by regenerative therapies in a wide variety of organs such as the liver, kidney, and heart. The concept of developing tooth banking and preservation of dental stem cells is promising. Further research in the area has the potential to herald a new dawn in effective treatment of notoriously difficult diseases which could prove highly beneficial to mankind in the long run.

Dental implants are frequently used to support fixed or removable dental prostheses to replace missing teeth. The clinical success of titanium dental implants is owed to the exceptional biocompatibility and osseointegration with the bone. Therefore, the enhanced therapeutic effectiveness of dental implants had always been preferred. Several concepts for implant coating and local drug delivery had been developed during the last decades. A drug is generally released by diffusion-controlled, solvent-controlled, and chemical controlled methods. Although a range of surface modifications and coatings (antimicrobial, bioactive, therapeutic drugs) have been explored for dental implants, it is still a long way from designing sophisticated therapeutic implant surfaces to achieve the specific needs of dental patients. The present article reviews various interdisciplinary aspects of surface coatings on dental implants from the perspectives of biomaterials, coatings, drug release, and related therapeutic effects. Additionally, the various types of implant coatings, localized drug release from coatings, and how released agents influence the bone–implant surface interface characteristics are discussed. This paper also highlights several strategies for local drug delivery and their limitations in dental implant coatings as some of these concepts are yet to be applied in clinical settings due to the specific requirements of individual patients.

Dental stem cells have been found to have the ability to differentiate into nerve cells, adipose cells, chondrocytes, osteoblasts, myocytes, hepatocytes, and odontoblasts. They can be derived from permanent teeth or deciduous teeth. Stem cells from human exfoliated deciduous teeth (SHED) have a higher proliferation rate and higher osteogenic and neurogenic potential than dental pulp stem cells (DPSC). Therefore, SHEDs are an attractive cell source for tissue regeneration. A large plethora of in vitro and animal studies have been conducted in the last few decades that has demonstrated the potential uses of these cells for the treatment of oral and non-oral diseases. The aim of this article was to review the potential therapeutic applications of stem cells derived from human exfoliated deciduous teeth. A Medline search was done, including international literature, published in English between 2003 and 2020. In this area, further research is needed to ensure the applicability of SHED in the treatment of diseases in humans.

Acceptable therapeutic protocol in dentistry depends on the outcomes obtained with follow up. Operative procedural errors (OPE) may occur and they represent risk factors able to compromise a tooth or a dental implant. The aim of this study was to detect the OPE in endodontically treated teeth and dental implants, using cone beam computed tomography (CBCT).Eight hundred and sixteen CBCT exams were performed between January 2009 and October 2010, and only those which presented endodontically treated teeth and/or dental implants were selected. The sample was as follows: 195 CBCT exams (n=200 teeth and 200 dental implants), 72 male, 123 female, with mean age of 51 years.In endodontically treated teeth, OPE included underfilling, overfilling, and root perforation; OPEin dental implants were thread exposures, contact with anatomical structures, and contact with adjacent teeth. Kolmogorov-Smirnov test was used for statistical analysis, with significance level set at α=0.05. Underfilling, overfilling, and root perforations were detected in 33.5%, 8% and 4.5% of the teeth, respectively. Dental implants with thread exposures, contact with important anatomical structures and contact with adjacent teeth were seen in 37.5%, 13% and 6.5% of the cases, respectively. OPE were detected in endodontically treated teeth and dental implants, and underfilling and thread exposures were the most frequent occurrences, respectively.

Orthodontics is a specialty of dental medicine that discovers and treat dento - maxillary abnormalities (or lack of teeth alignment - malocclusions - unsightly dental rotation, lack of congruence of the two dental arches) solving both aesthetic and functional problems ;contributes to improving dental and facial aesthetics, and implicitly to improving psychological well-being, self-esteem and quality of life. Orthodontic treatment is a support for multidisciplinary approach with other dental specialties in order to obtain facial and dental aesthetics; seeks to improve the appearance of smile and occlusion (bite) so that the teeth can bear without trauma the daily forces sore from the time of mastication; has the potential to eliminate future dental problems, including abnormal teeth wear. Dento-maxillary abnormalities synthesize current concepts of normal occlusion and explain the mechanisms by which dento-maxillary abnormalities occur, the morphological differences that allow classification and how they can affect the individual�s appearance. The study includes a wider group of pediatric patients aged between 7 and 11 years, growing showing a diverse pathology, periodontal dental trauma, dental abnormalities, which may require the prosthesis. It can be argued that in most chromosomal syndromes, oro-facial abnormalities are major symptoms as pathognomonic value for clinical diagnosis; involvement of other body regions in these syndromes are frequently nonspecific and common to several syndromes.The great variability of their treatment measures used in dental abnormalities requires knowledge of their causal factors, as well as their mechanism of action and production.

Hereditary coagulopathies characterized by reduced blood clotting occupy a special place among diseases of the blood system. The most common of these are hemophilia and Willebrand's disease. Hemophilia-the disease of "royals" - is an old, but still relevant disease. Hereditary coagulopathies, characterized by reduced blood clotting, occupy a special place among diseases of the blood system. Based on who data and the likely frequency of research on these diseases, the prevalence of hemophilia ranges from 3 to 25 patients per 10,000 population. Few studies of the oral cavity in patients with hemophilia have shown a high level of dental diseases, poor hygiene of the oral cavity. This is due to the lack of proper oral care, and dispensary monitoring, fear of prolonged bleeding after dental manipulations. For this reason, dentists try to avoid treating dental diseases in this category of patients. At the same time, modern achievements of medical science in the field of Hematology and the development of effective replacement therapy allow to prevent almost all types of bleeding. However, this group of patients is still unable to receive timely and high-quality dental treatment and prevention, which largely determines the high prevalence of inflammatory diseases of the maxillofacial region. All of the above is evidence of the presence of many predisposing factors of damage to the dental system in patients with hemophilia, as well as the need for preventive, therapeutic, including orthopedic dental measures for this category of patients.

Dental implants are a proven therapeutic option for replacing missing teeth, with positive long-term health outcomes. Dental implant performance is largely determined by the implant’s primary durability, which is affected by surgical procedure, bone quality and quantity, implant surface characteristics, implant geometry, and implant surface characteristics. The implant’s geometry and surface can be modified. The implant geometry and surface can be changed if needed to achieve good primary stability and long-term implant therapy effectiveness. Implant architecture refers to the implant’s three-dimensional structure, as well as all of the components and elements that make it up. Different surface topographies can affect a sequence of coordinated actions such cell proliferation, osteoblast transformation, and the production of bone tissue. At the macro, micro, and increasingly nano sizes, surface topography of implants may be detected. The surgical location of end osseous oral implants is influenced by the prosthetic architecture, as well as the shape and quality of the alveolar bone. There are several alternatives for replacing missing teeth, but within the past few decades, dental implants have been one of the most common biomaterials for replacing one (or more) missing teeth. In a substantial number of patients, titanium dental implants have been shown to be secure and reliable. This study examines the most important historical information of dental implants, as well as the various vital factors that will ensure successful Osseo-integration and a safe prosthesis anchorage. Not only

AbstractMultiple dental impactions not associated with craniofacial syndromes are a rare condition and present the dentist with a therapeutic challenge when it comes to performing surgical/restorative treatments in adult patients. This case report describes a geriatric patient with multiple impacted teeth restored by means of two different protocols. In the second quadrant, an impacted tooth was extracted followed by regeneration and placement of an implant. In the third quadrant, implants were placed though impacted teeth for restoration with a fixed partial prosthesis. Placing dental implants through impacted teeth may offer a possible therapeutic option for implant-supported restorations in middle-aged or elderly patients, for whom surgery and orthodontic traction are not possible, and/or patients who refuse to undergo more invasive extraction surgery.

Human mesenchymal stem cells (hMSCs) are multipotent cells, which exhibit plastic adherence, express specific cell surface marker spectrum, and have multi-lineage differentiation potential. These cells can be obtained from multiple tissues. Dental tissue-derived hMSCs (dental MSCs) possess the ability to give rise to mesodermal lineage (osteocytes, adipocytes, and chondrocytes), ectodermal lineage (neurocytes), and endodermal lineages (hepatocytes). Dental MSCs were first isolated from dental pulp of the extracted third molar and till now they have been purified from various dental tissues, including pulp tissue of permanent teeth and exfoliated deciduous teeth, apical papilla, periodontal ligament, gingiva, dental follicle, tooth germ, and alveolar bone. Dental MSCs are not only easily accessible but are also expandable in vitro with relative genomic stability for a long period of time. Moreover, dental MSCs have exhibited immunomodulatory properties by secreting cytokines. Easy accessibility, multi-lineage differentiation potential, and immunomodulatory effects make dental MSCs distinct from the other hMSCs and an effective tool in stem cell-based therapy. Several preclinical studies and clinical trials have been performed using dental MSCs in the treatment of multiple ailments, ranging from dental diseases to nondental diseases. The present review has summarized dental MSC sources, multi-lineage differentiation capacities, immunomodulatory features, its potential in the treatment of diseases, and its application in both preclinical studies and clinical trials. The regenerative therapeutic strategies in dental medicine have also been discussed.

Aim of research: to analyze the dental status of children with the teeth formation disorders on the background of the digestive diseases (DD). Object of research – the change of the teeth hard tissues and periodontal tissues, subject of research – clinical characteristics of the status of teeth hard tissues and periodontal ones. Results of research: in children with chronological enamel hypoplasia (CEH) and molar-incisor hypomineralization (MIH) on the background of digestive diseases (Class ICD-10, К00-К93: “Gastritis and duodenitis” (К29), “Cholecystitis” (К81), “Other bile-excreting diseases” (К83)) was fixed the high and very high intensity of the dental caries, respectively. Caries as CEH and MIH complication was diagnosed in 55,81 % and 42,85 % of examined, respectively. In children with CEH and MIH on the background of digestive organ diseases was diagnosed the middle severity of gingivitis РМА, Papillary, Marginal, Alveolar Indices): 29,13±8,87 % and 25,24±8,97 %, respectively. The rate of persons with the healthy periodontal tissues according to CPI (Community Periodontal Index) was 21,42±21,91 % in children with CEH and 7,14±13,11 % in examined with MIH. In examined with CEH and MIH was fixed the satisfactory hygiene of the oral cavity according to Green-Vermillion index (OHI – Oral Hygiene Index). Conclusion: children with teeth hard tissues formation disorders on the background of digestive diseases need the dispensary observation and course of the therapeutic and prophylactic arrangements for preventing the possible complications (caries, gingivitis, periodontitis).

Destructive forms of periodontal disease in children are uncommon. Severe periodontal destruction can be a manifestation of a systemic disease; however, in some patients, the underlying cause of increased susceptibility and early onset is still unknown. Objective: To describe an effective therapeutic approach to Generalized Aggressive Periodontitis (GAgP) in children, based on a 3-1/2 year-old male patient referred to the Hospital due to early loss of incisors, gingivitis,and tooth mobility in his primary dentition. Intraoral examination revealed severe gingival inflammation,dental abscesses, pathological tooth mobility, bleeding upon probing and attachment loss around several primary teeth. Dental radiographs revealed horizontal and vertical bone loss. Treatment consisted on the extraction of severely affected primary teeth, systemic antibiotics, deep scaling of remaining teeth and strict oral hygiene measures. Once the patient's periodontal condition was stabilized, function and esthetics were restored with "pedi-partials." After a follow-up period of nearly 4 years, the patient's periodontal status remains healthy, facilitating the eruption of permanent teeth. Conclusion: Prompt diagnosis and good treatment regimen may provide an effective therapeutic management of Generalized Aggressive Periodontitis.

Summary Background/Aim: Dental fluorosis is a specific disturbance of tooth formation caused by excessive intake of fluoride. The discoloration of teeth is the most common reason for parents to seek treatment. The purpose of this paper is to describe the therapeutic management performed in a 9-year-old girl with fluorosis. Case report: A clinical case of a 9-year-old girl diagnosed with fluorosis is reported. The treatment of this clinical case was achieved using microabrasion, which is a minimally invasive method. This technique improves the aesthetics of the teeth without causing significant loss of dental tissue; a characteristic making microabrasion applicable to children as well. Its implementation involved the combined use of 18% hydrochloric acid and pumice on the enamel surface of upper incisors. The improved appearance of the teeth was aesthetically pleasing and, consequently, the patient gained in self-confidence. Conclusions: In the literature, several treatment choices are proposed, depending on the severity of the fluorosis. In our case, microabrasion was applied and the aesthetic outcome satisfied both the patient and the dentist.

Nowadays, dental implants are a prominent therapeutic approach among dentists for replacing missing teeth. Failure in dental implants is a severe challenge recently. The factors which lead to dental implant failure are known. These factors can be categorized into different groups. In this article, we discussed the immunological aspects of implant failure as one of these groups. Cytokines and immune cells have extensive and various functions in peri-implantitis. The equilibrium between pro and anti-inflammatory cytokines and cells, which involve in this orchestra, has a crucial role in implant prognosis. In conclusion, immune cells, especially macrophages and dendritic cells, almost increased in the patients with implant failure. Also, proinflammatory cytokines were proposed as diagnostic factors according to their higher levels in dental implant rejection.

The problem of hard tissues of teeth discoloration treatment is relevant for modern practical dentistry due to the widespread use of endodontic treatment of anterior teeth, dental preservation operations and therapeutic treatment of caries and non-carious lesions of hard tissues of teeth. Teeth discoloration quite often happens as a complication of endodontic treatment, injuries, secondary caries and other lesions of hard tissues. The article describes a clinical case of the removal of discoloration of the front teeth of the upper jaw (after a tooth-preserving operation and previously performed tooth restorations) using the modern photopolymer composites material «Jen-Radiance» and «Jen-Favorite LC» made in Ukraine.

Purpose: To emphasize the esthetic result of bringing anterior teeth into alignment with orthodontic treatment, as a mean of smile makeover. Material and method: Clinical and imagistic evaluations were performed in 4 patients with chief complaints related to poor dental esthetics. An interdisciplinary approach integrating orthodontics, oral surgery and prosthetics into oral treatment planning was performed. The patients underwent orthodontic treatment. Teeth extraction in the laterally maxilla were performed for space management. Results and discussions: Initial situations and final results were clinically and imagistically compared. Considerable esthetic improvement was noticed in all cases and all patients were satisfied with the final results. Conclusions: Orthodontic therapy is the first choice in cases with crowding in the anterior maxilla and complex treatment needs. The esthetic results of orthodontic therapy are unique.

While the regeneration of a lost tissue is known to mankind for several years, it is only in the recent past that research on regenerative medicine/dentistry has gained momentum and eluded the dramatic yet scientific advancements in the field of molecular biology. The growing understanding of biological concepts in the regeneration of oral/dental tissues coupled with experiments on stem cells is likely to result in a paradigm shift in the therapeutic armamentarium of dental and oral diseases culminating in an intense search for “biological solutions to biological problems.” Stem cells have been successfully isolated from variety of human tissues including orofacial tissues. Mesenchymal stem cells (MSCs) are multipotent stem cells which differentiate into a variety of cell types. The potential MSCs for tooth regeneration mainly include stem cells from human exfoliated deciduous teeth (SHEDs), adult dental pulp stem cells (DPSCs), stem cells from apical part of the papilla (SCAPs), stem cells from the dental follicle (DFSCs), periodontal ligament stem cells (PDLSCs) and bone marrow derived mesenchymal stem cells (BMSCs). This review article outlines the recent progress in mesenchymal stem cells used in tooth regeneration.

Abstract Introduction. One of the indications for dental treatment in general anaesthesia of children and adolescents is the patients’ refusal to cooperate with the dentist; this concerns especially the so-called special care patients, and among them, those suffering from epilepsy. Aim. The aim of the study was to evaluate the structure of treatment procedures in conservative dentistry and dental surgery performed under general anaesthesia in children and adolescents with epilepsy. Material and methods. The analysis covered case histories of 109 patients with epilepsy, aged 3-18 years, who received dental treatment under general anaesthesia. The patients were divided into three age groups, according to the dentition type: patients with deciduous dentition - 3-5 years of age; with mixed dentition - 6-12 years, and with permanent dentition - 13-18 years. The analysis concerned the procedures on both deciduous and permanent teeth. Results. An average number of extractions in a child with full deciduous dentition was 3.9 teeth, while in a child with mixed dentition - 2.7 teeth. The greatest number of deciduous teeth extractions concerned first and second molars. Carious cavities in the occlusal surfaces of permanent teeth, due to deep caries, were the most frequently treated lesions. Conclusions. In patients with epilepsy treated under general anaesthesia, extensive treatment needs, resulting from prophylactic and therapeutic neglect in dental care, were found. Conservative and surgical treatment, combined with prophylactic procedures, performed under general anaesthesia seems one of the necessary elements of a complex dental care in uncooperative children and adolescents

Polymeric tooth-colored restorations are increasingly popular in dentistry. However, restoration failures remain a major challenge, and more than 50% of all operative work was devoted to removing and replacing the failed restorations. This is a heavy burden, with the expense for restoring dental cavities in the U.S. exceeding $46 billion annually. In addition, the need is increasing dramatically as the population ages with increasing tooth retention in seniors. Traditional materials for cavity restorations are usually bioinert and replace the decayed tooth volumes. This article reviews cutting-edge research on the synthesis and evaluation of a new generation of bioactive dental polymers that not only restore the decayed tooth structures, but also have therapeutic functions. These materials include polymeric composites and bonding agents for tooth cavity restorations that inhibit saliva-based microcosm biofilms, bioactive resins for tooth root caries treatments, polymers that can suppress periodontal pathogens, and root canal sealers that can kill endodontic biofilms. These novel compositions substantially inhibit biofilm growth, greatly reduce acid production and polysaccharide synthesis of biofilms, and reduce biofilm colony-forming units by three to four orders of magnitude. This new class of bioactive and therapeutic polymeric materials is promising to inhibit tooth decay, suppress recurrent caries, control oral biofilms and acid production, protect the periodontium, and heal endodontic infections.

Dental caries is one of the major diseases of the oral cavity affecting humans worldwide. Different alternatives have been used for its control, but its incidence and prevalence are still high. On the other hand, silver has been used for centuries due to its antimicrobial properties. With advances in nanotechnology, the use and research in nanomaterials has increased, recently, and silver nanoparticles have become an essential part of the dental practice, giving materials physical and chemical improvements in their properties, used for their antibacterial capacity preventing and arresting dental caries. The objective of this review was to examine the use of silver nanoparticles, in the treatment of dental caries in the remineralization of teeth hard tissues, as well as the antimicrobial potential, cytotoxicity, and long-term effectiveness.

Introduction. Dental caries is the most common oral health disease of school-aged children around the world. In this study, we aimed to assess the prevalence and associated factors of dental caries in primary schoolchildren in Yasuj township, Iran. Methods. In this cross-sectional study, a total of 460 children aged 7–12 years were investigated. Dental examination was performed at school according to the World Health Organization criteria. Sociodemographic data were collected using a structured questionnaire, and caries statuses of children’s teeth were recorded through a dental chart. Data were analyzed using summary statistics, chi-square test, and logistic regression model with odds ratio. Results. The prevalence of dental caries in primary, permanent, and whole dentition among children was 75.3%, 41.1%, and 89.8%, respectively. Among all considered factors, the caries presence in primary teeth was inversely (p<0.001) and in permanent teeth was positively (p<0.001) associated with the children’s age. Moreover, the odds of decaying permanent teeth were significantly higher in girls, in rural children, and in children whose fathers were not an employee compared to their counterparts (p=0.04, p<0.001, and p=0.02, respectively). Conclusions. The prevalence of dental caries among the studied primary schoolchildren in mixed dentition was high and associated with their sociodemographic factors. Providing and implementing preventive, therapeutic, and informative programs for controlling dental caries at individual, family, and school levels are necessary for local health policymakers.

Introduction: Stem cells are often hailed as the medicine of the 21st century. They provide us with potential tools to effectively counteract not only diseases, but even aging. For stomatology, stem cells are the technology of the future in the regeneration of the periodontium and pulp, and dental replantation and transplantation. Materials and methods: On the basis of a literature review, the previous achievements and potential capabilities of stem cell therapy were discussed, focusing on dental applications. Conclusions: The paper discusses the modulation of stem cells and their therapeutic potential and capabilities. The presence and properties of stem cells in the pulp of human deciduous and permanent teeth, the periodontal membrane and the dental sac are also discussed. The results of the studies conducted by the cited researchers are promising and give hope for the development of regenerative and restorative processes of the dental and periodontal tissues. Summary: In the future, stem cells obtained from primary and permanent teeth deposited in special dental banks will be able to prevent the degradation of periodontal tissue, or even heal the teeth.

Tooth decay is the most common dental disease in children, so the problem of prevention remains one of the most relevant in pediatric dentistry. Goal: development and implementation of health education and individual treatment and prevention activities for school-age children. Materials and methods. School-based SOUTH of the city of Moscow, teachers and students of the third year was held a programme for the prevention of dental diseases among pupils in primary classes, attended by 2300 people. Results. Employees of the Department of therapeutic Stomatology RNIMU them. N.i. Pirogov was established private dental diseases prevention programme, which already operates within 6 years the intensity of caries in permanent teeth CPU index teeth fell in children age 6 with 2.40 ± 0.06 to 0.97 ± 0.06 (p < 0.05), 12-year-olds with 3.74 ± 0.17 to 1.95 ± 0.16 (p < 0.05), 15 year olds with 4.86 ± 0.16 to 2.95 ± 0.13 (p < 0.05); reduction of intensity of caries increment amounted to 59.6%, respectively, 47.9% and 39.3%, with an increase in the number of children with healthy teeth that says showing clear positive impact on the level of oral hygiene Program Prevention of dental diseases.

Stem cells derived from human dental pulp tissue (DP-MSC) differ from the other mesenchymal stem cells prepared from bone marrow or adipose tissue due to their embryonic origin from the neural crest and are of special interest because of their neurotropic character. Furthermore, the therapeutic potential of DP-MSCs is realized through paracrine action of extracellularly released components, for which exosomes play an important role. In this review, we intend to explore the properties of these cells with an emphasis on exosomes. The therapeutic applicability of these cells and exosomes in dental practice, neurodegenerative diseases, and many other difficultly treatable diseases, like myocardial infarction, focal cerebral ischemia, acute lung or brain injury, acute respiratory distress syndrome, acute inflammation, and several others is concisely covered. The use of cellular exosomes as an important diagnostic marker and indicator of targeted cancer therapies is also discussed, while the importance of stem cells from human exfoliated deciduous teeth as a source of evolutionally young cells for future regenerative therapies is stressed. We conclude that exosomes derived from these cells are potent therapeutic tools for regenerative medicine in the near future as clinical administration of DP-MSC-conditioned medium and/or exosomes is safer and more practical than stem cells.

Abstract Introduction. Many factors affect the oral health of the population. These include individual factors, the effectiveness of dental care, life styles and political, economic and environmental factors. Aim. The aim of the study was to evaluate the type of financing dental care and frequency of dental visits among patients treated with implants because of missing teeth. Material and methods. The survey was conducted among 464 patients of both genders aged 20-74 years, treated with dental implants at the Non-Public Healthcare Centre “Dental” in Tomaszów Mazowiecki. The patients answered questions included in anonymous questionnaire. The questions concerned age, education, type of dental care financing and frequency of dental visits. Results. Results of the survey indicate that among patients treated with implants there were over 14-times more people benefiting from dental care in private clinics providing preventive and restorative treatments at full cost, compared with people using dental services funded by the National Health Fund. Just over 16% of the surveyed patients frequently enough, i.e. at least once in 6 months reported to the dentist. The frequency of dental visits increased with the education level - people with vocational and secondary education most often visited a dentist irregularly, when necessary, while those with higher education - once a year. Patients below 60 years reported to the dentist 1-2 times a year, whereas older - irregularly, when necessary. Conclusion. In preparing the patient for the treatment of missing teeth with implants one should be aware of his need for paying special attention to oral health and regular, sufficiently frequent follow-up visits which has a substantial impact on the course and therapeutic success in the implant prosthetic treatment

Dental trauma is an important public health problem due to high prevalence and associated limitations. The external impact accounting for trauma may result in different injury types to teeth and supporting structures. This paper describes a clinical case of tooth trauma in an 8-year-old patient exhibiting the displacement of three permanent teeth with open root apexes. Although the traumatic impact resulted in two injury types to teeth and supporting tissues (lateral luxation and alveolar bone fracture), the therapeutic approach was the same in both situations. The bone and teeth were repositioned by digital pressure, stabilized by semirigid splint, and followed up at every week. After six weeks, the splint was removed. At that moment, the clinical and radiographic findings indicated normal soft/hard tissues and absence of pulp/periodontal pathologies. At the fifth year of follow-up, the treatment success of the case was confirmed, although it has been observed that all lower incisors exhibited pulp obliteration as a consequence of the dental trauma.

Coronal fractures of permanent dentition are the most frequent type of dental injury. Fractured anterior teeth are usually treated with conventional post and core and crown techniques, after being treated endodontically. If the original tooth fragment is retained following fracture, the natural tooth structures can be reattached using adhesive protocols. Fiber-reinforced post makes the reattachment of the crown esthetically possible with minimal preparation and reduces the possibility of tooth fracture during function. This paper presents the therapeutic approach of reattachment of crown fragment to the tooth at the cervical and middle third levels.

Dr Greene Vardiman Black in the year 1896 classified dental caries into VI classes based on the site of occurrence, among which class III and class IV are exclusively associated with anterior teeth. There are very minimal studies in the literature emphasising on the prevalence of dental caries in the anterior teeth region. Caries involving the anterior teeth significantly affects aesthetics and which in turn affects the confidence levels of the affected person. Grossly decayed anterior teeth also affect phonetics and mastication. The aim of this study was to determine the prevalence and gender variations of class III dental caries among patients who have visited Saveetha Dental College and have undergone treatment for the same. A Retrospective study was conducted, and data collection was done from dental archives pertaining from June 2019 to April 2020. Data consisted of all the patients who underwent therapeutic procedures for class all dental caries. Data was imported to IBM SPSS Version 20 for statistical analysis. Results were tabulated. Prevalence of class III dental caries was more among females as compared to males. Maxillary anterior are more affected than mandibular anterior. Prevalence was more among patients belonging to the third and fourth decade of life. There was a statistically significant association between age, and proximal surface –majority of mesial caries decreases with age and distal caries increases with age. As the age increases, the number of decayed surfaces increases (not statistically significant). This study was conducted in a single centre. Extensive multi-centre studies need to be done.

Introduction. The growing population of the elderly people and a proportional increase in the number of the elderly with different types of disabilities, necessitates a multidisciplinary approach to the assessment of their oral health and dental treatment. The ultimate aim is to retain a pain-free functional dentition and decrease the risk of future disease. Material and Methods. A PubMed search was performed and the authors contributed their experience in implementing preventive and therapeutic measures. Oral health problems of the elderly with disabilities. Two main factors influence the oral health: multimorbidity and polypharmacy. Oral health problems expected in this population are teeth abrasion, teeth fractures, root caries, periodontitis and problems with wearing dentures due to stomatitis caused by Candida albicans. Oral health assessment and treatment guidelines. This article provides guidelines for assessment and treatment planning, taking into consideration multimorbidity, polypharmacy, dementia and capacity of caregivers. Preventive measures. Preventive measures are crucial for long-term oral health of this population, and this paper provides guidelines for preventive treatment depending on the degree of functional dependence. Prosthetic treatment. Although some elderly with disabilities are suitable for conventional prosthetic treatment, often there are contraindications and specific considerations that must be taken into account. Conclusion. Oral health needs of the elderly people with disabilities should not be neglected and the success of treatment depends on the education of dental professionals and cooperation with other health professionals of the medical team.

Since mesenchymal stem cells derived from human teeth are characterized as having the properties of excellent proliferation, multilineage differentiation, and immune regulation. Dental stem cells exhibit fibroblast-like microscopic appearance and express mesenchymal markers, embryonic markers, and vascular markers but do not express hematopoietic markers. Dental stem cells are a mixed population with different sensitive markers, characteristics, and therapeutic effects. Single or combined surface markers are not only helpful for understanding the subpopulation of mixed stem cell populations according to cell function but also for improving the stable treatment effect of dental stem cells. Focusing on the discovery and characterization of stem cells isolated from human teeth over the past 20 years, this review outlines the effect of marker sorting on cell proliferation and differentiation ability and the assessment of the clinical application potential. Classified dental stem cells from markers and functional molecules can solve the problem of heterogeneity and ensure the efficacy of cell therapy strategies including dentistry, neurologic diseases, bone repair, and tissue engineering.

Introduction: Teeth displacement in the maxillary sinus is one of the most frequently described peri-extraction complications in oral surgery. Roots or whole teeth accidentally displaced during an avulsion process are the most common cause of foreign bodies in the maxillary sinus. It exposes the patient to more or less serious complications that can go as far as development of pneumonia or septic thrombosis of the cavernous sinus in rare cases. Several therapeutic solutions can be proposed to manage this complication, ranging from therapeutic abstention to the removal of the dental component using various techniques. Corpus: The pedagogical objectives of this article are to explain the main characteristics of this complication as well as its treatment. Through a systematic review of the literature according to the PRISMA methodology, the risk factors, prevention, diagnosis, complications, and management of teeth displacement will be discussed. A treatment decision tree will be proposed to guide practitioners in the management of a tooth or dental root displaced into the sinus. Conclusion: This article summarizes the importance of pre-extraction radiographic examinations for preventive purposes and their analysis to guide the practitioner in the choice of an appropriate surgical technique. Furthermore, the surgical management in almost all cases must be carried out early to prevent later infectious complications.

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{mso-style-name:"Tabela normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi;} --> <!--[endif]--><span style="font-size: 11pt; font-family: " lang="EN-US">The survival of an avulsed permanent tooth depends on the management and the appropriate treatment of the injury by the dental surgeon. The aim of this study was to assess the knowledge of first-year and last-year dental undergraduates on guidelines for management and treatment of tooth avulsion. A 10-item multiple-choice questionnaire was distributed among 65 first-year and 60 last-year dental undergraduates at the School of Dentistry, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Brazil, between 2006 and 2007. Answers were graded 0 to 3. The results revealed a low level of knowledge among first-year and last-year students on the management and treatment of permanent avulsed teeth. Knowledge of last-year undergraduates of tooth avulsion was lower than what is required for a future dental surgeon. In conclusion, there is a need to improve the knowledge of dental students in the guidelines for the management of tooth avulsion. Because tooth avulsion is the most prevalent lesion in dentoalveolar traumas, it is of the utmost importance that dental surgeons be prepared to treat it properly, avoiding damage to neighboring teeth and structures, and esthetic, functional, psychosocial and therapeutic implications for the patient.</span>

Summary Introduction Direct pulp capping is an important therapeutic method that has goal to provide formation of dentin bridge and healing process of the pulp. The aim of this study was to investigate the effects of new nanostructural materials based on calcium silicate systems and hydroxyapatite on exposed dental pulp in Vietnamese pigs. Material and Methods The study was conducted on 30 teeth of two Vietnamese pigs (Sus scrofa verus). On buccal surfaces of incisors, canines and first premolars, class V cavities were prepared with a small round bur and pulp horn was exposed. In the first experimental group (10 teeth) the perforation was covered with new nanostructural material based on calcium silicate systems (CS). In the second experimental group, the perforation was covered with compound of calcium silicate systems and hydroxyapatite (HA-CS) (10 teeth). In the control group, exposed pulp was covered with Pro Root MTA® (Dentsply Tulsa Dental, Johnson City, TN, USA) (10 teeth). All cavities were restored with glass ionomer cement (GC Fuji VIII, GC Corporation, Tokyo, Japan). Observation period was 28 days. After sacrificing the animals, histological preparations were done to analyze the presence of dentin bridge, inflammatory reaction of the pulp, pulp tissue reorganization and the presence of bacteria. Results Dentin bridge was observed in all teeth (experimental and control groups). Inflammation of the pulp was mild to moderate in all groups. Neoangiogenesis and many odontoblast like cells responsible for dentin bridge formation were detected. Necrosis was not observed in any case, neither the presence of Gram-positive bacteria in the pulp. Conclusion Histological analysis indicated favorable therapeutic effects of new nanostructural materials based on calcium silicate systems and hydroxyapatite for direct pulp capping in teeth of Vietnamese pigs.

It is of interest to evaluate the frequency of premolar extractions during orthodontic treatment in patients reporting to the Saveetha dental hospital in Chennai from 2019-2020. We used the records from 987 patients who underwent orthodontic treatment from June 2019 to March 2020 in a dental hospital for this analysis. Digital case records of patients who underwent therapeutic extractions of premolars were isolated. A sample dataset of 340 case records were selected for this study. Data shows that 34.4% of subjects underwent premolar extractions amongst a total of 987 subjects who underwent orthodontic treatment. 89.4% of patients were Angle’s Class I malocclusion patients, and the rest were Class II patients. However, no premolar extractions were done in Class III patients. Data also shows that 67.1% of subjects underwent all 4 first premolar extractions and 13.2% underwent only upper first premolar extractions. Thus, a significant association was found between Type of Malocclusion and the Type of premolar extractions with p < 0.05. Moreover, only 34.4% of patients underwent premolar extractions and the majority of them underwent all 4 first premolar extractions.

It is of interest to evaluate the frequency of premolar extractions during orthodontic treatment in patients reporting to the Saveetha dental hospital in Chennai from 2019-2020. We used the records from 987 patients who underwent orthodontic treatment from June 2019 to March 2020 in a dental hospital for this analysis. Digital case records of patients who underwent therapeutic extractions of premolars were isolated. A sample dataset of 340 case records were selected for this study. Data shows that 34.4% of subjects underwent premolar extractions amongst a total of 987 subjects who underwent orthodontic treatment. 89.4% of patients were Angle’s Class I malocclusion patients, and the rest were Class II patients. However, no premolar extractions were done in Class III patients. Data also shows that 67.1% of subjects underwent all 4 first premolar extractions and 13.2% underwent only upper first premolar extractions. Thus, a significant association was found between Type of Malocclusion and the Type of premolar extractions with p < 0.05. Moreover, only 34.4% of patients underwent premolar extractions and the majority of them underwent all 4 first premolar extractions.

The aim: To determine the structure of acute injuries of temporary and permanent frontal teeth in children, to analyze the applied diagnostic and treatment measures for acute tooth trauma and to investigate their effectiveness. Materials and methods: The subject of the study were 31 children aged 2-12 years with acute temporary and permanent tooth trauma. Methods: clinical (radiological, thermodiagnosis), medical and statistical. Results: The number of injured permanent teeth was greater than the number of injured temporary teeth. The pattern of temporary and permanent tooth injuries differed, so in temporary teeth dislocations were observed, and in permanent teeth fractures prevailed over dislocations. In our opinion, this is due to the peculiarities of the anatomy of the temporary teeth. Usually, the therapeutic tactics of acute temporary teeth injuries is to remove them, despite their important role in the growth and development of jaws, physiological formation and eruption of permanent teeth. The therapeutic tactics of dynamic observation in the case of intrusive dislocation of the temporary tooth were selected in the clinic of the Department of Pediatric Dentistry. In some cases, with a slight change in the position of the temporary tooth, self-regulation of its position was observed, in other cases the tooth remained dystopic, but its viability remained in 50% of cases. Therapeutic tactics of acute injuries of permanent teeth were selected according to the type of trauma. In the case of permanent tooth dislocation, with a slight change in its position, tooth immobilization was carried out by splinting with fiberglass tape and photopolymer composite material. Conclusions: Our observations have shown that the complex of modern specialized medical care for the affected children with acute traumatic injuries of the teeth should be guided by their preservation, which ensures the subsequent normal formation of the dental-jaw apparatus. To ensure these conditions, a long, reliable immobilization of the damaged tooth is required as soon as possible after injury.

This retrospective study aimed to evaluate the dental trauma profile in primary and permanent teeth from patients between 0 and 15 years old who attended the Faculty of Dentistry of the Federal University of Rio de Janeiro. Data regarding gender, age, trauma classification, tooth type, and affected tissues were obtained from dental records. The data were analyzed descriptively and by the χ2 test (p < 0.05). Data associated with 333 traumatized teeth (70% primary and 30% permanent teeth) were included. The mean ages of children with affected primary and permanent teeth were 3.35 ± 2.02 and 9.09 ± 2.43 years, respectively. Males presented more permanent teeth with trauma (64.4%) than primary ones (55.6%; p = 0.085). The upper central incisors, both primary (68.9%) and permanent (69.4%), were the teeth most commonly affected. Primary teeth showed a higher frequency (p < 0.001) of supportive tissue trauma (73.3%) and lower frequency (p = 0.001) of hard tissue trauma (40.7%) than those in permanent ones (51.5% and 60.6%, respectively). The most frequent trauma in the supportive tissue was subluxation (27.2%) and permanent lateral luxation (42.0%). In the hard tissues, permanent teeth presented a higher prevalence of trauma than primary ones (p = 0.001), however this difference was not statistical significant when each type of fracture injury was evaluated individually (p > 0.005). With affected primary teeth, there was a greater frequency of trauma in the gingival mucosa (31.0%; p = 0.022); in the permanent ones, traumatic lesions in the chin region were the most prevalent (20.8%; p = 0.009). Trauma was recurrent in 26.3% of primary teeth and in 20.2% permanent teeth. Therefore, primary and permanent teeth showed distinct trauma profiles, suggesting that distinct preventive and therapeutic approaches are needed for these two groups.

Clinical Relevance This article presents the dental restoration of a young female patient complaining of erosive dental wear using a three-step restorative technique, an alternative approach with some novel adjustments. SUMMARY For successful tooth wear treatment, determining the etiological systemic and local factors is the main priority before deciding on effective and long-term preventive and/or therapeutic restorative approaches. In addition to professional intervention, achieving optimal outcomes requires patients to control their diet and/or gastric issues, thus minimizing the wear process. However, continuous wear constitutes the most challenging scenario, mainly when it affects young patients’ dentitions. This article describes the dental restoration of posterior teeth with reestablishment of occlusal vertical dimension before treating the anterior teeth, while educating the patient and providing medical monitoring. The three-step restorative technique seems to be properly applicable in cases of significant dental compromise due mainly to erosive wear and is based on direct procedures, which can assure a reliable and feasible approach.

Dental implant treatment is an important therapeutic modality with documented long-term success for replacement of missing teeth. However, dental implants can be susceptible to disease conditions or healing complications that may lead to implant loss. This case-control study identified several risk indicators associated with failure such as smoking and alcohol consumption. The use of postoperative antibiotics or wide-diameter implants may significantly reduce implant failure. Knowledge of patient-related risk factors may assist the clinician in proper case selection and treatment planning.