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Relevant bibliographies by topics / Telomerase activity and

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Academic literature on the topic 'Telomerase activity and'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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Journal articles on the topic "Telomerase activity and"

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Criscuolo, F., S. Smith, S. Zahn, B. J. Heidinger, and M. F. Haussmann. "Experimental manipulation of telomere length: does it reveal a corner-stone role for telomerase in the natural variability of individual fitness?" Philosophical Transactions of the Royal Society B: Biological Sciences 373, no. 1741 (2018): 20160440. http://dx.doi.org/10.1098/rstb.2016.0440.

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Telomeres, the non-coding ends of linear chromosomes, are thought to be an important mechanism of individual variability in performance. Research suggests that longer telomeres are indicative of better health and increased fitness; however, many of these data are correlational and whether these effects are causal are poorly understood. Experimental tests are emerging in medical and laboratory-based studies, but these types of experiments are rare in natural populations, which precludes conclusions at an evolutionary level. At the crossroads between telomere length and fitness is telomerase, an

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Chen, W., S. M. Chen, Y. Yu, B. K. Xiao, Z. W. Huang, and Z. Z. Tao. "Telomerase inhibition alters telomere maintenance mechanisms in laryngeal squamous carcinoma cells." Journal of Laryngology & Otology 124, no. 7 (2010): 778–83. http://dx.doi.org/10.1017/s0022215109992854.

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AbstractBackground and purpose:Telomere length must be maintained throughout cancer cell progression and proliferation. In most tumours, telomerase activity maintains telomere length. Therefore, telomerase is a target for cancer treatments. However, some cancer cells maintain telomere length through an alternative mechanism termed ‘alternative lengthening of telomeres’. To determine how telomerase inhibition relates to the initiation of the alternative lengthening of telomeres pathway, we investigated telomerase activity and telomere maintenance in Hep-2 cells with and without reduced telomera

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Han, Xuesheng, Alice Hirschel, Menelaos Tsapekos, Diego Perez, and David Vollmer. "In Vitro Assessment of Gold Nanoparticles on Telomerase Activity and Telomere Length in Human Fibroblasts." International Journal of Molecular Sciences 24, no. 18 (2023): 14273. http://dx.doi.org/10.3390/ijms241814273.

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Telomerase activity coincides with lengthening of the ends of chromosomes known as telomeres. Telomere length is used as a marker for cellular aging. Telomeres shorten over time as cells divide, and certain bioactive compounds such as gold nanoparticles (AuNPs) may slow the shortening of telomeres by increasing telomerase activity. The objective of the present study is to assess the effect of AuNPs on telomerase activity and telomere length in human fibroblasts. Telomerase activity was measured using enzyme-linked immunosorbent assay (ELISA) in primary human lung fibroblasts (IMR90) and using

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Beery, Annaliese K., Jue Lin, Joshua S. Biddle, Darlene D. Francis, Elizabeth H. Blackburn, and Elissa S. Epel. "Chronic stress elevates telomerase activity in rats." Biology Letters 8, no. 6 (2012): 1063–66. http://dx.doi.org/10.1098/rsbl.2012.0747.

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The enzyme telomerase lengthens telomeres—protective structures containing repetitive DNA sequences at chromosome ends. Telomere shortening is associated with diseases of ageing in mammals. Chronic stress has been related to shorter immune-cell telomeres, but telomerase activity under stress may be low, permitting telomere loss, or high, partially attenuating it. We developed an experimental model to examine the impacts of extended unpredictable stress on telomerase activity in male rats. Telomerase activity was 54 per cent higher in stressed rats than in controls, and associated with stress-r

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Counter, CM, J. Gupta, CB Harley, B. Leber, and S. Bacchetti. "Telomerase activity in normal leukocytes and in hematologic malignancies." Blood 85, no. 9 (1995): 2315–20. http://dx.doi.org/10.1182/blood.v85.9.2315.bloodjournal8592315.

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Telomeres are essential for function and stability of eukaryotic chromosomes. In the absence of telomerase, the enzyme that synthesizes telomeric DNA, telomeres shorten with cell division, a process thought to contribute to cell senescence and the proliferative crisis of transformed cells. We reported telomere stabilization concomitant with detection of telomerase activity in cells immortalized in vitro and in ovarian carcinoma cells, and suggested that telomerase is essential for unlimited cell proliferation. We have now examined the temporal pattern of telomerase expression in selected hemat

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Wang, Fang, David H. McCulloh, Kasey Chan, et al. "The Landscape of Telomere Length and Telomerase in Human Embryos at Blastocyst Stage." Genes 14, no. 6 (2023): 1200. http://dx.doi.org/10.3390/genes14061200.

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The telomere length of human blastocysts exceeds that of oocytes and telomerase activity increases after zygotic activation, peaking at the blastocyst stage. Yet, it is unknown whether aneuploid human embryos at the blastocyst stage exhibit a different profile of telomere length, telomerase gene expression, and telomerase activity compared to euploid embryos. In present study, 154 cryopreserved human blastocysts, donated by consenting patients, were thawed and assayed for telomere length, telomerase gene expression, and telomerase activity using real-time PCR (qPCR) and immunofluorescence (IF)

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Zhou, Jianlong, Kyoko Hidaka, and Bruce Futcher. "The Est1 Subunit of Yeast Telomerase Binds the Tlc1 Telomerase RNA." Molecular and Cellular Biology 20, no. 6 (2000): 1947–55. http://dx.doi.org/10.1128/mcb.20.6.1947-1955.2000.

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ABSTRACT Est1 is a component of yeast telomerase, and est1mutants have senescence and telomere loss phenotypes. The exact function of Est1 is not known, and it is not homologous to components of other telomerases. We previously showed that Est1 protein coimmunoprecipitates with Tlc1 (the telomerase RNA) as well as with telomerase activity. Est1 has homology to Ebs1, an uncharacterized yeast open reading frame product, including homology to a putative RNA recognition motif (RRM) of Ebs1. Deletion of EBS1 results in short telomeres. We created point mutations in a putative RRM of Est1. One mutan

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Ray, Alo, and Kurt W. Runge. "The C Terminus of the Major Yeast Telomere Binding Protein Rap1p Enhances Telomere Formation." Molecular and Cellular Biology 18, no. 3 (1998): 1284–95. http://dx.doi.org/10.1128/mcb.18.3.1284.

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ABSTRACT The telomeres of most organisms consist of short repeated sequences that can be elongated by telomerase, a reverse transcriptase complex that contains its own RNA template for the synthesis of telomere repeats. In Saccharomyces cerevisiae, the RAP1gene encodes the major telomere binding protein Rap1p. Here we use a quantitative telomere formation assay to demonstrate that Rap1p C termini can enhance telomere formation more than 30-fold when they are located at internal sites. This stimulation is distinct from protection from degradation. Enhancement of formation required the gene for

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Perera, Omesha N., Alexander P. Sobinoff, Erdahl T. Teber, et al. "Telomerase promotes formation of a telomere protective complex in cancer cells." Science Advances 5, no. 10 (2019): eaav4409. http://dx.doi.org/10.1126/sciadv.aav4409.

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Telomerase is a ribonucleoprotein complex that catalyzes addition of telomeric DNA repeats to maintain telomeres in replicating cells. Here, we demonstrate that the telomerase protein hTERT performs an additional role at telomeres that is independent of telomerase catalytic activity yet essential for telomere integrity and cell proliferation. Short-term depletion of endogenous hTERT reduced the levels of heat shock protein 70 (Hsp70-1) and the telomere protective protein Apollo at telomeres, and induced telomere deprotection and cell cycle arrest, in the absence of telomere shortening. Short-t

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Yehorova, M. S., D. S. Krasnienkov, V. G. Gurianov, V. Ye Kondratiuk, and V. М. Kuharskiy. "RELATIONSHIP OF TELOMERE LENGTH, TELOMERASE ACTIVITY, AND OXIDATIVE STRESS MARKERS IN PATIENTS WITH CEREBRAL ATHEROSCLEROSIS AND TYPE 2 DIABETES." Клінічна та профілактична медицина 4, no. 9-10 (2019): 117–27. http://dx.doi.org/10.31612/2616-4868.4(10).2019.06.

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The aim of study is to determine the relationship between telomere length and telomerase activity with indicators of oxidative stress in patients with stage 1-3 cerebral atherosclerosis and type 2 diabetes. Material and methods. A total clinical and instrumental study involved 161 patients with grade 1–3 CA. Telomerase activity was determined using a tandem repeat amplification protocol with real-time detection. The relative telomere lengths were measured using real-time multiplex quantitative polymerase chain reaction. Results. A comparative analysis revealed that patients with st

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Dissertations / Theses on the topic "Telomerase activity and"

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Hirsch, Erica. "Telomerase activity and telomere lengths in fibroblast cells treated with ependymin peptide mimetics." Link to electronic thesis, 2005. http://www.wpi.edu/Pubs/ETD/Available/etd-050505-134911/.

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Bestilny, Leslie James. "Regulation of telomere length and telomerase activity during aging and immortality." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape8/PQDD_0014/NQ38456.pdf.

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Betts, Dean Harvey. "Analysis of telomerase activity and telomere length during early bovine development." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/NQ61967.pdf.

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Adekunle, Adesole A. "Evaluation of telomerase activity and telomerase inhibitors in Head and Neck cancer." Thesis, University of Bradford, 2019. http://hdl.handle.net/10454/17457.

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Cancer is a major cause of morbidity and mortality with increasing incidence worldwide. Early detection of cancers and better treatments would improve the outcome for patients. The overall 5-year survival rates of head and neck squamous cell carcinoma have not improved in the past several decades due to diagnosis at advanced stages and recurrent disease. Early detection and improved chemotherapy drugs are two key areas that are required to help to improve the prognosis for this disease. This thesis focuses on the enzyme telomerase which is known to contribute to one of the hallmarks of cancer

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Mills, Juliet Ann. "Telomerase activity in normal and malignant haematopoiesis." Thesis, Queen Mary, University of London, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.417611.

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Lindkvist, Anna. "Activity and Regulation of Telomerase in Malignant Cells." Doctoral thesis, Uppsala University, Department of Genetics and Pathology, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-6623.

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<p>An important step in tumorgenesis is the acquisition of cellular immortality. Tumor cells accomplish this by activating the enzyme telomerase, and thereby avoiding replicative senescence. The aim of this thesis was to study the activity and regulation of telomerase in a panel of malignant cell types.</p><p>We found that TGF-β1 (transforming growth factor-β1) mediated differential effects on telomerase activity in five ATC (anaplastic thyroid carcinoma) cell lines. Cells that harbored a <i>p53</i> mutation responded by up-regulation of telomerase activity after TGF-β1 treatment, whereas cell

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Bermudez, Yira. "Growth Factor-Mediated Telomerase Activity in Ovarian Cancer Cells." [Tampa, Fla.] : University of South Florida, 2007. http://purl.fcla.edu/usf/dc/et/SFE0002028.

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Xu, Dawei. "Telomerase activity and its regulation in malignant hematopoietic cells /." Stockholm, 1999. http://diss.kib.ki.se/1999/91-628-3815-6/.

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Yu, Jie. "Microfluidic electrochemical detection of prostate cancer using telomerase activity." Thesis, University of British Columbia, 2010. http://hdl.handle.net/2429/30528.

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Prostate cancer has become one of the leading causes of death and the most frequently diagnosed cancer in men, worldwide. It is highly treatable if detected early, but the current screening methods suffer from poor clinical specificity for prostate cancer, leading to unavoidable misdiagnosis and overtreatment. Elevated telomerase activity has been discovered as an indicator of a variety of cancers, including over 92 % of prostate cancers. High clinical specificity of telomerase activity for prostate cancer compared to other prostate anomalies is an important concept promoted in this thesis. To

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Flanary, Barry Eric. "Analysis of rat microglial cellular senescence as determined by measurements of telomere length and telomerase activity." [Gainesville, Fla.] : University of Florida, 2005. http://purl.fcla.edu/fcla/etd/UFE0009641.

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Thesis (Ph.D.)--University of Florida, 2005.<br>Typescript. Title from title page of source document. Document formatted into pages; contains 161 pages. Includes Vita. Includes bibliographical references.

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Books on the topic "Telomerase activity and"

1

Albert, Natalie. Inducing senescence in cancer cells by inhibiting telomerase activity using telomestatin. Laurentian University, 2006.

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Miu, Andrei C., Judith R. Homberg, and Klaus-Peter Lesch, eds. Genes, brain, and emotions. Oxford University Press, 2019. http://dx.doi.org/10.1093/oso/9780198793014.001.0001.

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With the advent of methods from behavioral genetics, molecular biology, and cognitive neuroscience, affective science has recently started to approach genetic influences on emotion, and the underlying intermediate neural mechanisms through which genes and experience shape emotion. The aim of this volume is to offer a comprehensive account of current research in the genetics of emotion, written by leading researchers, with extensive sections focused on methods, intermediate phenotypes, and clinical and translational work. Major methodological approaches are reviewed in the first section, includ

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Book chapters on the topic "Telomerase activity and"

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Xin, Huawei. "Telomeric Repeat Amplification Protocol: Measuring the Activity of the Telomerase." In Telomeres and Telomerase. Humana Press, 2011. http://dx.doi.org/10.1007/978-1-61779-092-8_10.

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Eduardo Gómez, Daniel, Diego Luis Mengual Gómez, Lina Maloukh, and Romina Gabriela Armando. "Telomerase Activity." In Telomeres, Diet and Human Disease. CRC Press, 2017. http://dx.doi.org/10.1201/9781315152431-2.

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Hiyama, Eiso. "Protocol I: Telomerase Activity and Telomerase Expression." In Telomeres and Telomerase in Cancer. Humana Press, 2009. http://dx.doi.org/10.1007/978-1-60327-879-9_14.

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Wang, Feng, and Ming Lei. "Human Telomere POT1-TPP1 Complex and Its Role in Telomerase Activity Regulation." In Telomeres and Telomerase. Humana Press, 2011. http://dx.doi.org/10.1007/978-1-61779-092-8_17.

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Joseph, Nithila A., Chi-Fan Chen, Jiun-Hong Chen, and Liuh-Yow Chen. "Monitoring Telomere Maintenance During Regeneration of Annelids." In Methods in Molecular Biology. Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-2172-1_24.

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AbstractTelomere shortening is a hallmark of aging and eventually constrains the proliferative capacity of cells. The protocols discussed here are used for monitoring telomeres comprehensively in Aeolosoma viride, a model system for regeneration studies. We present methods for analyzing the activity of telomerase enzyme in regenerating tissue by telomeric repeat amplification protocol (TRAP) assay, for comparing telomere length between existing tissue and newly regenerated tissue by telomere restriction fragment (TRF) assay, as well as for visualizing telomeres by fluorescence in situ hybridiz

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Saied Hosseini-Asl, S., and P. Mehdipour. "Detection of Telomerase Activity: A New Strategy for Detecting Low Activity of Telomerase." In Telomere Territory and Cancer. Springer Netherlands, 2012. http://dx.doi.org/10.1007/978-94-007-4632-9_3.

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Stöppler, H., M. Conrad Stöppler, M. Kisiela, et al. "Merkel Cell Carcinomas Possess Telomerase Activity." In The Merkel Cell. Springer Berlin Heidelberg, 2003. http://dx.doi.org/10.1007/978-3-662-10358-6_35.

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Aydin, Yasemin. "Antiaging Strategies Based on Telomerase Activity." In Molecular Basis and Emerging Strategies for Anti-aging Interventions. Springer Singapore, 2018. http://dx.doi.org/10.1007/978-981-13-1699-9_7.

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Maritz, Michelle F., Laura A. Richards, and Karen L. MacKenzie. "Assessment and Quantification of Telomerase Enzyme Activity." In Methods in Molecular Biology. Humana Press, 2012. http://dx.doi.org/10.1007/978-1-62703-239-1_14.

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Banerjee, Partha P., and Shankar Jagadeesh. "Non-Radioactive Assay Methods for the Assessment of Telomerase Activity and Telomere Length." In Methods in Molecular Biology. Humana Press, 2009. http://dx.doi.org/10.1007/978-1-59745-190-1_25.

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Conference papers on the topic "Telomerase activity and"

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Yin, J., Z. Zhang, and Z. Song. "Terahertz waves enhance telomerase activity and prolong cellular telomere length." In 2024 IEEE International Conference on Plasma Science (ICOPS). IEEE, 2024. http://dx.doi.org/10.1109/icops58192.2024.10625849.

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Yin, J., Z. Zhang, and Z. Song. "Terahertz Waves Attenuate Telomerase Activity to Suppress Tumor Cell Growth." In 2024 IEEE International Conference on Plasma Science (ICOPS). IEEE, 2024. http://dx.doi.org/10.1109/icops58192.2024.10625776.

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Ghosh, Shresth. "RIOK2 transcriptionally regulates telomerase activity to prevent telomere shortening." In International Conference on Cell Science and Regenerative Medicine. United Research Forum, 2024. https://doi.org/10.51219/urforum.2024.shresth-ghosh.

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Drenberg, Christina D., Yira Bermudez, Santo V. Nicosia, and Patricia A. Kruk. "Abstract 3208: Semaphorin 3F suppresses telomerase activity." In Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1538-7445.am10-3208.

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Chumak, Z., A. Zelinsky, V. Artyomenko, and N. Shapoval. "226 Telomerase endometrial cells activity in hyperplastic processes." In IGCS Annual 2019 Meeting Abstracts. BMJ Publishing Group Ltd, 2019. http://dx.doi.org/10.1136/ijgc-2019-igcs.226.

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Fleisig, Helen B., and Judy M. Y. Wong. "Abstract B32: Telomerase activity confers growth and DNA damage survival advantages in telomerase-negative transformed human cells." In Abstracts: Second AACR International Conference on Frontiers in Basic Cancer Research--Sep 14-18, 2011; San Francisco, CA. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/1538-7445.fbcr11-b32.

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Shelton, Dawne, Jack Regan, George Karlin-Neumann, Jue Lin, and Elizabeth Blackburn. "Abstract LB-253: TRAPing telomerase activity using droplet digital PCR." In Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1538-7445.am2013-lb-253.

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Zhou, Xiaoming, Da Xing, Debin Zhu, and Li Jia. "Rapid and quantitative measuring of telomerase activity using an electrochemiluminescent sensor." In Advanced Sensor Systems and Applications III. SPIE, 2008. http://dx.doi.org/10.1117/12.760222.

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Mouraret, Nathalie, Guillaume Gary-Bobo, Elisabeth Marcos, et al. "Progression Of Experimental Hypoxic Pulmonary Hypertension Is Related To Telomerase Activity." In American Thoracic Society 2012 International Conference, May 18-23, 2012 • San Francisco, California. American Thoracic Society, 2012. http://dx.doi.org/10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a5288.

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Chang-Huang, S., J. Fitzpatrick, G. Dai, et al. "Telomere Length and Telomerase Activity Are Associated With COPD and Lung Function Abnormalities in Persons Living With HIV." In American Thoracic Society 2023 International Conference, May 19-24, 2023 - Washington, DC. American Thoracic Society, 2023. http://dx.doi.org/10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a1137.

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Reports on the topic "Telomerase activity and"

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Griffith, J. Telomerase activity in human cancer. Office of Scientific and Technical Information (OSTI), 2000. http://dx.doi.org/10.2172/766184.

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Hnatyszyn, Harry, and Gunter K. Kraus. Design of a Ribozyme to Inactive Telomerase Activity in Breast Tumors. Defense Technical Information Center, 1999. http://dx.doi.org/10.21236/ada391356.

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Hnatyszyn, Harry J., and Gunter Kraus. Design of a Ribozyme to Inactivate Telomerase Activity in Breast Cancer Tumors. Defense Technical Information Center, 2000. http://dx.doi.org/10.21236/ada392898.

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Botchkina, Galina I. Early Detection of Prostate Cancer with a New Data Acquisition System for Telomerase Activity Analysis. Defense Technical Information Center, 2004. http://dx.doi.org/10.21236/ada427174.

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Botchkina, Galina I., and Howard L. Adler. Validation of Quantitative Multimodality Analysis of Telomerase Activity in Urine Cells as a Noninvasive Diagnostic and Prognostic Tool for Prostate Cancer. Defense Technical Information Center, 2005. http://dx.doi.org/10.21236/ada468571.

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