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Journal articles on the topic 'Template aging'

Author: Grafiati
Published: 4 June 2021
Last updated: 1 February 2022

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1

Akhtar, Zahid, Ajita Rattani, and Gian Luca Foresti. "Temporal Analysis Of Adaptive Face Recognition." Journal of Artificial Intelligence and Soft Computing Research 4, no. 4 (October 1, 2014): 243–55. http://dx.doi.org/10.1515/jaiscr-2015-0012.

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Abstract Aging has profound effects on facial biometrics as it causes change in shape and texture. However, aging remains an under-studied problem in comparison to facial variations due to pose, illumination and expression changes. A commonly adopted solution in the state-of-the-art is the virtual template synthesis for aging and de-aging transformations involving complex 3D modelling techniques. These methods are also prone to estimation errors in the synthesis. Another viable solution is to continuously adapt the template to the temporal variation (ageing) of the query data. Though efficacy of template update procedures has been proven for expression, lightning and pose variations, the use of template update for facial aging has not received much attention so far. Therefore, this paper first analyzes the performance of existing baseline facial representations, based on local features, under ageing effect then investigates the use of template update procedures for temporal variance due to the facial age progression process. Experimental results on FGNET and MORPH aging database using commercial VeriLook face recognition engine demonstrate that continuous template updating is an effective and simple way to adapt to variations due to the aging process.
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2

Fenker, S. P., E. Ortiz, and K. W. Bowyer. "Template Aging Phenomenon in Iris Recognition." IEEE Access 1 (2013): 266–74. http://dx.doi.org/10.1109/access.2013.2262916.

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3

Khan, Aisha, and Stacey L. Gorniak. "Effects of Force Requirements on Pinch Force Production in Healthy Adults." Motor Control 20, no. 3 (July 2016): 299–315. http://dx.doi.org/10.1123/mc.2014-0081.

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Previous studies of fine motor control have focused on the ability of participants to match their grip force production to a visually provided template. We investigated differences exhibited in pinch force control during variable force production templates, including sine-, sawtooth-, and square-wave templates. Our results indicate that increased force requirements are associated with increased error rates and a noisier frequency spectrum, consistent with previous studies. Our results also indicate that visual feedback, in the form of template shape, directly affect pinch force production features and motor unit firing patterns, despite the use of consistent baseline force requirements, amplitude changes, and visual signal frequency. This suggests that CNS modulation of motor unit responses can be triggered by basic changes in visual feedback unrelated to force requirements. The potential implications of error compensation based on this study due to aging are also discussed.
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4

Zheng, Wei, Chengxin Zhang, Qiqige Wuyun, Robin Pearce, Yang Li, and Yang Zhang. "LOMETS2: improved meta-threading server for fold-recognition and structure-based function annotation for distant-homology proteins." Nucleic Acids Research 47, W1 (May 13, 2019): W429—W436. http://dx.doi.org/10.1093/nar/gkz384.

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Abstract The LOMETS2 server (https://zhanglab.ccmb.med.umich.edu/LOMETS/) is an online meta-threading server system for template-based protein structure prediction. Although the server has been widely used by the community over the last decade, the previous LOMETS server no longer represents the state-of-the-art due to aging of the algorithms and unsatisfactory performance on distant-homology template identification. An extension of the server built on cutting-edge methods, especially techniques developed since the recent CASP experiments, is urgently needed. In this work, we report the recent advancements of the LOMETS2 server, which comprise a number of major new developments, including (i) new state-of-the-art threading programs, including contact-map-based threading approaches, (ii) deep sequence search-based sequence profile construction and (iii) a new web interface design that incorporates structure-based function annotations. Large-scale benchmark tests demonstrated that the integration of the deep profiles and new threading approaches into LOMETS2 significantly improve its structure modeling quality and template detection, where LOMETS2 detected 176% more templates with TM-scores >0.5 than the previous LOMETS server for Hard targets that lacked homologous templates. Meanwhile, the newly incorporated structure-based function prediction helps extend the usefulness of the online server to the broader biological community.
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5

Jagminas, Arūnas, Kęstutis Mažeika, Jonas Reklaitis, Marija Kurtinaitienė, and Dalis Baltrūnas. "Template synthesis, characterization and transformations of iron nanowires while aging." Materials Chemistry and Physics 109, no. 1 (May 2008): 82–86. http://dx.doi.org/10.1016/j.matchemphys.2007.10.036.

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6

Zhang, Sai, Shuang Song, Pengcheng Gu, Ran Ma, Dongli Wei, Guixia Zhao, Tao Wen, Riffat Jehan, Baowei Hu, and Xiangke Wang. "Visible-light-driven activation of persulfate over cyano and hydroxyl group co-modified mesoporous g-C3N4 for boosting bisphenol A degradation." Journal of Materials Chemistry A 7, no. 10 (2019): 5552–60. http://dx.doi.org/10.1039/c9ta00339h.

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7

Sun, Felice T., Roberta A. Schriber, Joel M. Greenia, Jiawei He, Amy Gitcho, and William J. Jagust. "Automated template-based PET region of interest analyses in the aging brain." NeuroImage 34, no. 2 (January 2007): 608–17. http://dx.doi.org/10.1016/j.neuroimage.2006.09.022.

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8

Shan, Wei Jun, Wei Wang, and Hong Qiang Ru. "Synthesis of Plugged Mesoporous SBA-15-Type Silicas from Sodium Silicate." Key Engineering Materials 512-515 (June 2012): 568–74. http://dx.doi.org/10.4028/www.scientific.net/kem.512-515.568.

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Nonionic triblock copolymers (P123) templated SBA-15 silicas since 1998 have attracted great interests due to their larger pores, thicker pore walls, etc. Following that, extensive works were devoted to tailor the textural and morphological properties of SBA-15s, among which the SBA-15 with plugs formed in mesoschannels, called plugged hexagonal templated silica (PHTS), was one of famous examples. This work presents a simple but effective method to prepare PHTS-type SBA-15s based on the partitioned cooperative self-assembly process using P123 as template and cheap sodium silicate as silica precursor, which is in contrast with most other works using TEOS as silica precursor. Various techniques, including XRD, TEM and N2 sorption, have been employed to characterize the resultant PHTS-type SBA-15s. For this method, synthetic parameters, especially the interval time and aging temperatures, were found to have great influence on the plugged mesostructures.
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9

Zhao, Qing Nan, Ying Liu, Shao Hong Hou, Wu Zeng, and Jie Sun. "Preparation and Characterization of Nano-Porous SiO2/TiO2-SiO2 Thin Films on Glass Substrates by Sol-Gel Method." Key Engineering Materials 531-532 (December 2012): 651–54. http://dx.doi.org/10.4028/www.scientific.net/kem.531-532.651.

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Nano-porous bilayers structure antireflection films on glass substrate were prepared by sol-gel method, tetraethyl orthosilicate(TEOS) and tetrabutyl titanate(TEOT) as the main raw materials, cetyl trimethyl ammonium bromide(CTAB) and polyethylene glycol(PEG) as template. The relation of the template agent addition, pH, and aging time to surface morphology and optical properties were analyzed. When the CTAB/TEOS = 1/30, the average spectral transmittance in the visible wavelength is 93.69% and the peak transmission is up to 97.37%. All the bilayers antireflection films are amorphous structure, uniform surface morphology, dense nano-porous size distribution, pore size is about 10nm.
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10

Harvey, John, John Campbell, and Andy Adler. "Characterization of Biometric Template Aging in a Multiyear, Multivendor Longitudinal Fingerprint Matching Study." IEEE Transactions on Instrumentation and Measurement 68, no. 4 (April 2019): 1071–79. http://dx.doi.org/10.1109/tim.2018.2861998.

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11

Huang, Yang Feng, Ye Bin Cai, and Hao Liu. "A Self-Assembly Approach to Fabricate Bi2S3 Nanorods." Advanced Materials Research 139-141 (October 2010): 51–54. http://dx.doi.org/10.4028/www.scientific.net/amr.139-141.51.

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Bismuth sulfide (Bi2S3) nanorods were successfully fabricated by sonochemical aqueous solution. The morphology, crystallinity and composition of samples at various growth stages were investigated by transmission electron microscopy (TEM), selected area electron diffraction (SAED) and X-ray diffraction (XRD). The results showed that the Bi2S3 nuclei had an obvious tendency to arrange themselves in rod-like arrays over extended length scales under soft template. Moreover the crystallinity would be reinforced with the elongation of the aging periods. The growth mode of particle−to−particle by self-assembly under soft template was proposed. The band gap energy of Bi2S3 nanorods was estimated at about 1.36 eV by UV-Vis absorption spectroscopy.
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12

Mu, Liang, WeiWei Feng, Haobin Zhang, Xiubin Hu, and Qingyan Cui. "Synthesis and catalytic performance of a small crystal NaY zeolite with high SiO2/Al2O3 ratio." RSC Advances 9, no. 36 (2019): 20528–35. http://dx.doi.org/10.1039/c9ra03324f.

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A small crystal NaY zeolite with a high SiO2/Al2O3 ratio was successfully synthesized with seeding and without organic template, and the effects of the silicon source, aging time and Na2O seeding content on the crystal size of the NaY zeolite were investigated.
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Ma, Zhi Jun, Yi Min Zhu, Yan Jun Li, and Xin Fang. "Research on Preparation of Mesoporous Zeolite by Template Method." Advanced Materials Research 158 (November 2010): 204–10. http://dx.doi.org/10.4028/www.scientific.net/amr.158.204.

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In this paper, the preparation of mesoporous zeolite by template method is studied that the mesoporous zeolite is made up of pure silica source and pure aluminum source. The synthesis mechanism of mesoporous zeolite is investigated according to the characterization results of FTIR, SEM and N2 adsorption-desorption. The results shows that the water glass and sodium aluminate as the partial raw materials of synthesis process, P123 as the template, reaction at 42°C for 20h, aging at 54°C for 48 h, calcining at 550°C for 5 h. The average pore size of prepared mesoporous zeolite is 6.4nm and the specific surface area is 394.65m2/g. The FTIR shows that the microstructure of the prepared samples is similar to zeolite ore, and the SEM result indicates that the micromorphology of the product is uniform and pore size is within the mesoporous range.
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14

Fakir, Muhamad Saipul, Azzuliani Supangat, and Khaulah Sulaiman. "Properties of Y-Shaped PFO-DBT Nanotubes." Journal of Nanomaterials 2014 (2014): 1–7. http://dx.doi.org/10.1155/2014/672798.

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Immersion of template into solution is used to synthesize the Y-shaped poly[2,7-(9,9-dioctylfluorene)-alt-4,7-bis(thiophen-2-yl)benzo-2,1,3-thiadiazole] (PFO-DBT) nanotubes. Solution annealing and different aging times (1, 24, and 72 hours) are conducted to synthesize the Y-shaped PFO-DBT nanotubes and the effects on the morphological, structural, and optical properties of Y-shaped PFO-DBT nanotubes are investigated. The dense, aligned, and elongated Y-shaped PFO-DBT nanotubes have been successfully fabricated by aging the PFO-DBT solution for 72 hours. Enhanced light absorption with less light scattering can be exhibited from the elongated Y-shaped PFO-DBT nanotubes. Partial and complete infiltration is governed by 1 hour and 72 hours of aging time, respectively. Preformed nanofibres are initiated by the process of annealing and aging of PFO-DBT solution. During the aging process, PFO-DBT nanofibres are formed to coat the pores’ wall and replicated the Y-branched nanopores for the production of Y-shaped PFO-DBT nanotubes. The effects of solution annealing and aging process are essential for the improvement on the morphological, structural, and optical properties of Y-shaped PFO-DBT nanotubes.
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15

Zhang, Ming, Y. Bando, and K. Wada. "Silicon dioxide nanotubes prepared by anodic alumina as templates." Journal of Materials Research 15, no. 2 (February 2000): 387–92. http://dx.doi.org/10.1557/jmr.2000.0061.

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Aligned slicon dioxide nanotubes with diameters of 30–40 nm synthesized by the sol-gel template method are presented. This process involves the growth of nanotubes from ordered nanochannel-array pores in anodic alumina. For a silica sol aged at room temperature and dipped for 1 min, nanowires were formed in a shorter period of aging time (2 days); nanotubes connecting with solid nanofibers were obtained in a longer aging time (30 days). The formation of nanotubes depends strongly on the temperature of the sol. For a short dipping time (<1 min), bamboolike nanofibers were prepared when the sol was at high temperature (50 °C); however, perfect nanotubes with the sharp wall were synthetized for the lower sol temperature (5 °C). The lower sol temperature is, the smoother the inside wall of nanotubes is. It is proved that viscosity plays an important role on the morphology of nanotubes.
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16

Studholme, C., V. Cardenas, E. Song, F. Ezekiel, A. Maudsley, and M. Weiner. "Accurate Template-Based Correction of Brain MRI Intensity Distortion With Application to Dementia and Aging." IEEE Transactions on Medical Imaging 23, no. 1 (January 2004): 99–110. http://dx.doi.org/10.1109/tmi.2003.820029.

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17

Jun, Jong Won, Imteaz Ahmed, Chul-Ung Kim, Kwang-Eun Jeong, Soon-Yong Jeong, and Sung Hwa Jhung. "Synthesis of ZSM-5 zeolites using hexamethylene imine as a template: Effect of microwave aging." Catalysis Today 232 (September 2014): 108–13. http://dx.doi.org/10.1016/j.cattod.2013.08.017.

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18

Wang, Ning Ning, Chun Ling Yu, Hong Yi Dai, Ying Huan Fu, Guo Lin Shao, and Xiao Li Dong. "Ionic Liquid-Assisted Synthesis of Anatase Nanostructured TiO2 Aerogel Doped with Fe3+ by a Low Temperature Sol-Gel Process and its Photocatalytic Performance." Advanced Materials Research 785-786 (September 2013): 365–69. http://dx.doi.org/10.4028/www.scientific.net/amr.785-786.365.

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Anatase crystalline TiO2 aeroge and TiO2 aerogel doped with Fe3+ were prepared at low temperature (60°C) using ionic liquid (IL) assisted sol-gel method. In this system, ionic liquid was not only an effective solvent but also an important template, which enhanced the polycondensation and crystallization rate, facilitated the formation of anatase crystal. Due to the effect of template, anatase crystalline TiO2 aerogel can be synthesized at the aging temperature of 60°C and drying under ambient pressure. The as-synthesized samples were characterized by X-ray power diffraction (XRD), scanning electron microscopes (SEM). The photocatalytic performance of pure TiO2 aerogel and TiO2 aerogel doped with Fe3+ aerogel was evalutaed by decolorization of reactive brilliant blue under visible light irridation. The results indicated that TiO2 aerogel doped with Fe3+ exhibited higher photocatalytic activity than pure TiO2 aerogel and Degussa P25.
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19

Chen, Shixing, Ming Dong, and Dongxiao Zhu. "Learning and Interpreting Features to Rank." International Journal of Multimedia Data Engineering and Management 9, no. 3 (July 2018): 17–36. http://dx.doi.org/10.4018/ijmdem.2018070102.

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Previously, it was taken for granted that features learned for classification can also be used for ranking. However, ranking problems possess some distinctive properties, e.g., the ordinal class labels, which indicates the necessity of developing new feature learning procedures dedicated for ranking. In this article, the authors propose to use a convolutional neural network (CNN)-based framework, ranking-CNN, for learning and interpreting features to rank. As a case study, the authors propose to analyze, visualize and work to understand the deep aging patterns in human facial images using ranking-CNN. The authors develop a visualization method that can compare the facial appearance and track its changes at different ages through the mapping between 2D images and a 3D face template. The framework provides an innovative way to understand the human facial aging process.
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20

Misra, Vikas, Hannah Lee, Anju Singh, Kewu Huang, Rajesh K. Thimmulappa, Wayne Mitzner, Shyam Biswal, and Clarke G. Tankersley. "Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes." Physiological Genomics 31, no. 3 (November 2007): 429–40. http://dx.doi.org/10.1152/physiolgenomics.00060.2007.

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This study identified gene expression profiles that provided evidence for genomic mechanisms underlying the pathophysiology of aging lung. Aging lungs from C57BL/6 (B6) and DBA/2 (D2) mouse strains differ in physiology and morphometry. Lungs were harvested from B6 mice at 2, 18, and 26 mo and from D2 mice at 2 and 18 mo of age. Purified RNA was subjected to oligonucleotide microarray analyses, and differential expression analyses were performed for comparison of various data sets. A significant majority of differentially expressed genes were upregulated with aging in both strains. Aging D2 lungs uniquely exhibited upregulation in stress-response genes including xenobiotic detoxification cascades. In contrast, aging B6 lungs showed downregulation of heat shock-response genes. Age-dependent downregulation of genes common to both B6 and D2 strains included several collagen genes (e.g., Col1a1 and Col3a1). There was a greater elastin gene ( Eln) expression in D2 mice at 2 mo, and Eln was uniquely downregulated with age in this strain. The matrix metalloproteinase 14 gene ( Mmp14), critical to alveolar structural integrity, was also downregulated with aging in D2 mice only. Several polymorphisms in the regulatory and untranslated regions of Mmp14 were identified between strains, suggesting that variation in Mmp14 gene regulation contributes to accelerated aging of lungs in D2 mice. In summary, lungs of B6 and D2 mice age with variable rates at the gene expression level, and these quantifiable genomic differences provide a template for understanding the variability in age-dependent changes in lung structure and function.
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Lupusoru, Raoul Vasile, Laurentiu Simion, Ion Sandu, Daniela Angelica Pricop, Aurica Chiriac, and Vladimir Poroch. "Aging Study of Gold Nanoparticles Functionalized with Chitosan in Aqueous Solutions." Revista de Chimie 68, no. 10 (November 15, 2017): 2385–88. http://dx.doi.org/10.37358/rc.17.10.5891.

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We studied the way in which stability and physicochemical properties of gold (Au) nanoparticles (NP) coated with chitosan are influenced by the molecular weight of chitosan and Au precursor concentration when samples are subjected to aging. Pharmaceutical use of AuNPs coated with chitosan is closely related to stability and physicochemical properties in relation to storage conditions and processing. For this purpose, series of AuNPs of different sizes were prepared by aqueous chemical reduction method using chitosan with various molecular weights as template. The physicochemical properties and stability at room temperature of AuNPs in aqueous solutions of chitosan have been investigated by following the temporal evolution of surface plasmon absorbance, Zeta potential, average dimension, and Au-chitosan interaction, after synthesis and through a period of 24 months. In our experiment, during the observed aging period, the AuNPs coated with chitosan presented a better colloidal stability, while using chitosan with medium molecular weight and medium concentration of Au precursor.
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22

Kunarti, Eko Sri, and Grainne M. Moran. "A STUDY OF THE SYNTHESIS OF HYBRID ORGANOSILICATE NANOTUBES." Indonesian Journal of Chemistry 5, no. 2 (June 14, 2010): 83–86. http://dx.doi.org/10.22146/ijc.21810.

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Hybrid organosilicate nanotubes have been prepared by sol-gel chemistry, using crystalline ammonium tartrate as the tube-forming template. The nanotubes were prepared by controlled hydrolysis and co-condensation of tetraethyl orthosilicate (TEOS) and methyltriethoxysilane (MTES) at room temperature. The synthetic conditions have been systematically studied. The physical characteristics of the materials were examined by scanning electron microscopy (SEM) and the aging times of the tubes due to slow post-gelation condensation reactions was investigated. The morphology and microstructure of the nanotubes are greatly influenced by the synthetic conditions. Keywords: organosilicate, nanotube, ammonium tartrate crystals.
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23

Ediati, Ratna, Amirul Mukminin, and Nurul Widiastuti. "Impregnation Nickel on Mesoporous ZSM-5 Templated Carbons as a Candidate Material for Hydrogen Storage." Indonesian Journal of Chemistry 17, no. 1 (April 1, 2017): 30. http://dx.doi.org/10.22146/ijc.23563.

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A series of carbon with ZSM-5 mesoporous (ZMC) and Ni/ZMC ZSM-5 templates were synthesized and gravimetrically known its adsorption capacity to H2 gases. ZMC carbon was synthesized using a hard template method at a carbonation temperature of 900 oC with sucrose as a source of carbon. A mesoporous ZSM-5 template was synthesized by using a hydrothermal method at an aging and crystallization temperature of respectively 60oC and 150oC for as long as 24 hours. The characterized result of ZMC carbon using XRD powder has shown a diffracted pattern of amorphous carbon. Impregnating Ni with ZMC carbon each resulted in 5%, 15% and 25% of weight, which in turn also resulted in a diffractogram pattern of Ni/ZMC-5, Ni/ZMC-15, and Ni/ZMC-25, where each patterns were uniform and had no additional peaks. The results of SEM-EDAX showed that Ni had been successfully impregnated on the surface of ZMC carbon with a random morphology surface of ZMC carbon. The isothermal results of adsorption – desorption of N2 showed that the larger the Ni loading on the supporting ZMC carbon, the smaller the surface area of the ZMC specific carbon. The distribution of the pore size that was counted by using the BJH method, which was applied to all the samples, was as big as 3,8 nm. The adsorption capacity of H2 was measured by using the gravimetry method at ambient temperature for Ni/ZMC-5, Ni/ZMC-15, and Ni/ZMC-25, which each gave a weight percentage of 0,331%; 0,663% and 0,649% respectively, whilst the ZMC carbon has a weight of 2,18%.
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Bae, Green, Eugene Kim, Hye-Young Kwon, Yong-Chan Ha, Jongryun An, Jeehye Park, and Hyowon Yang. "Burden of Osteoporotic Fractures Using Disability-Adjusted Life Years in South Korea." Asia Pacific Journal of Public Health 32, no. 2-3 (March 2020): 111–17. http://dx.doi.org/10.1177/1010539520916376.

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There is an increase in the number of patients with osteoporotic fractures due to the aging population in Korea. This study investigated the burden of osteoporotic fractures including hip, spine, and wrist fractures in the Korean population by estimating disability-adjusted life years (DALYs). The DALY for a given condition in a population captures years of life lost due to premature death and years of life lived with a disability and its severity and duration. To calculate DALYs from all relevant data collected for the 3 conditions, we used a DALY calculation template provided by the World Health Organization in 2014. DALYs per 100 000 for vertebral fractures (3168) were higher than those of hip fractures (2496) in women. Wrist fractures (1038) had the least burden, and the difference between men and women was the lowest. The aging population is expected to increase the burden of osteoporosis.
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25

Finkelstein, Ruth. "THE ROLE OF GERONTOLOGISTS IN CONTRIBUTING TOWARD PUBLIC POLICY TO ACHIEVE THE UN’S SUSTAINABLE DEVELOPMENT GOALS." Innovation in Aging 3, Supplement_1 (November 2019): S76. http://dx.doi.org/10.1093/geroni/igz038.297.

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Abstract The UN SDGs are aspirational goals whose achievement requires intentional policy-making at each level of government. Advocates for older people argued for goals specifically addressing older people, the fastest growing segment of the world’s population. While unsuccessful, we did achieve a targets monitoring template that reports outcomes separately by age. This innovation will bring helpful attention to generational differences in needs and progress, but gerontologists must play a critical role for this innovation to be realized as a benefit. Gerontologists must actively prevent SDG implementation for older people from being siloed into aging services departments. Aging services agencies do not have the resources or skills to achieve the SDGs – they do not control policy levers to end poverty, ensure gender equity or sustainable urban development. Yet, too often, once a population is separately counted, responsibility for its wellbeing follows. Gerontologists must help governments adopt an “age in everything” lens.
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Alfaro, S., C. Rodríguez, M. A. Valenzuela, and P. Bosch. "Aging time effect on the synthesis of small crystal LTA zeolites in the absence of organic template." Materials Letters 61, no. 23-24 (September 2007): 4655–58. http://dx.doi.org/10.1016/j.matlet.2007.03.009.

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27

Brown, Christopher A., Nathan F. Johnson, Amelia J. Anderson-Mooney, Gregory A. Jicha, Leslie M. Shaw, John Q. Trojanowski, Linda J. Van Eldik, Frederick A. Schmitt, Charles D. Smith, and Brian T. Gold. "Development, validation and application of a new fornix template for studies of aging and preclinical Alzheimer's disease." NeuroImage: Clinical 13 (2017): 106–15. http://dx.doi.org/10.1016/j.nicl.2016.11.024.

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28

Osterhage, Jennifer L., and Katherine L. Friedman. "Chromosome End Maintenance by Telomerase." Journal of Biological Chemistry 284, no. 24 (March 12, 2009): 16061–65. http://dx.doi.org/10.1074/jbc.r900011200.

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Telomeres, protein-DNA complexes at the ends of eukaryotic linear chromosomes, are essential for genome stability. The accumulation of chromosomal abnormalities in the absence of proper telomere function is implicated in human aging and cancer. Repetitive telomeric sequences are maintained by telomerase, a ribonucleoprotein complex containing a reverse transcriptase subunit, a template RNA, and accessory components. Telomere elongation is regulated at multiple levels, including assembly of the telomerase holoenzyme, recruitment of telomerase to the chromosome terminus, and telomere accessibility. This minireview provides an overview of telomerase structure, function, and regulation and the role of telomerase in human disease.
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29

Shankar, N., S. Sathish Babu, and C. Viswanathan. "Femur Bone Volumetric Estimation for Osteoporosis Classification Using Optimization-Based Deep Belief Network in X-Ray Images." Computer Journal 62, no. 11 (March 14, 2019): 1656–70. http://dx.doi.org/10.1093/comjnl/bxz011.

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AbstractOsteoporosis classification is a significant requirement in the medical field to automatically classify the patients with skeleton disorder that occurs as a result of aging. The classification algorithms required improved accuracy and computationally less complexity. Accordingly, this paper proposes a classification method using the proposed gradient harmony search (GHS) optimization-based deep belief network. The GHS is developed by integrating the harmony search (HS) in the gradient descent (GD) algorithm. The osteoporosis classification is progressed as five major steps: preprocessing, segmentation using active shape model, geometric estimation using the proposed template search method, feature extraction for extracting the medical and image level features, and osteoporosis classification using the proposed GHS based deep belief network. The proposed template search method updates the geometric points of the femur segment effectively and automatically. Experimentation using the real-time database ensures the effectiveness of the proposed method in terms of accuracy, sensitivity, and specificity. The proposed method acquired the accuracy of 0.9539, proving that the osteoporosis classification using the proposed algorithm seems to be effective in taking accurate decisions regarding the patients.
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Du, Xiaobing, Johnny Shen, Nishan Kugan, Emma E. Furth, David B. Lombard, Catherine Cheung, Sally Pak, et al. "Telomere Shortening Exposes Functions for the Mouse Werner and Bloom Syndrome Genes." Molecular and Cellular Biology 24, no. 19 (October 1, 2004): 8437–46. http://dx.doi.org/10.1128/mcb.24.19.8437-8446.2004.

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ABSTRACT The Werner and Bloom syndromes are caused by loss-of-function mutations in WRN and BLM, respectively, which encode the RecQ family DNA helicases WRN and BLM, respectively. Persons with Werner syndrome displays premature aging of the skin, vasculature, reproductive system, and bone, and those with Bloom syndrome display more limited features of aging, including premature menopause; both syndromes involve genome instability and increased cancer. The proteins participate in recombinational repair of stalled replication forks or DNA breaks, but the precise functions of the proteins that prevent rapid aging are unknown. Accumulating evidence points to telomeres as targets of WRN and BLM, but the importance in vivo of the proteins in telomere biology has not been tested. We show that Wrn and Blm mutations each accentuate pathology in later-generation mice lacking the telomerase RNA template Terc, including acceleration of phenotypes characteristic of latest-generation Terc mutants. Furthermore, pathology not observed in Terc mutants but similar to that observed in Werner syndrome and Bloom syndrome, such as bone loss, was observed. The pathology was accompanied by enhanced telomere dysfunction, including end-to-end chromosome fusions and greater loss of telomere repeat DNA compared with Terc mutants. These findings indicate that telomere dysfunction may contribute to the pathogenesis of Werner syndrome and Bloom syndrome.
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Dunford, Emily C., Jason S. Au, Michaela C. Devries, Stuart M. Phillips, and Maureen J. MacDonald. "Cardiovascular aging and the microcirculation of skeletal muscle: using contrast-enhanced ultrasound." American Journal of Physiology-Heart and Circulatory Physiology 315, no. 5 (November 1, 2018): H1194—H1199. http://dx.doi.org/10.1152/ajpheart.00737.2017.

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Skeletal muscle is the largest and most important site of capillary-tissue exchange, especially during high-energy demand tasks such as exercise; however, information regarding the role of the microcirculation in maintaining skeletal muscle health is limited. Changes in microcirculatory function, as observed with aging, chronic and cardiovascular diseases, and exercise, likely precede any alterations that arise in larger vessels, although further investigation into these changes is required. One of the main barriers to addressing this knowledge gap is the lack of methodologies for quantifying microvascular function in vivo; the utilization of valid and noninvasive quantification methods would allow the dynamic evaluation of microvascular flow during periods of clinical relevance such as during increased demand for flow (exercise) or decreased demand for flow (disuse). Contrast-enhanced ultrasound (CEUS) is a promising noninvasive technique that has been used for diagnostic medicine and more recently as a complementary research modality to investigate the response of the microcirculation in insulin resistance, diabetes, and aging. To improve the reproducibility of these measurements, our laboratory has optimized the quantification protocol associated with a bolus injection of the contrast agent for research purposes. This brief report outlines the assessment of microvascular flow using the raw time-intensity curve incorporated into gamma variate response modeling. CEUS could be used to compliment any macrovascular assessments to capture a more complete picture of the aging vasculature, and the modified methods presented here provide a template for the general analysis of CEUS within a research setting.
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Witoon, Thongthai, Metta Chareonpanich, and Jumras Limtrakul. "Size control of nanostructured silica using chitosan template and fractal geometry: effect of chitosan/silica ratio and aging temperature." Journal of Sol-Gel Science and Technology 56, no. 3 (August 6, 2010): 270–77. http://dx.doi.org/10.1007/s10971-010-2303-9.

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Shatters, Robert G., Mark E. Schweder, S. H. West, Ashraf Abdelghany, and Rex L. Smith. "Environmentally induced polymorphisms detected by RAPD analysis of soybean seed DNA." Seed Science Research 5, no. 2 (June 1995): 109–16. http://dx.doi.org/10.1017/s0960258500002683.

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AbstractExperiments were performed to determine if RAPD profiles developed using total DNA isolated from soybean seed could be affected by the physiological state or the quality of the seed. RAPD profiles were developed using template DNA isolated from a single seed lot of soybean (Glycine max L. cv. Kirby). High quality seeds were used to produce four populations varying in either quality or physiological state: untreated control seed ambient temperature and humidity storage for 12 months, accelerated aging at 41°C and 100% relative humidity for 48 h, and controlled hydration (seed priming). One hundred and eighty-eight primers were used to create separate RAPD profiles from total DNA isolated from each set of seed and from soybean leaf tissue. Sixteen polymorphisms from 14 primers were identified as a result of seed treatments. Six primers showed nine polymorphisms in RAPD profiles of ambient-stored seed DNA, while four and two primers produced polymorphisms in reactions using accelerated aged or primed-seed template DNA, respectively. Two primers showed a polymorphic fragment in vegetative DNA not observed in any of the seed DNA samples. Ten of the observed polymorphisms were due to the appearance of a DNA fragment in response to a specific seed treatment while six were the result of the treatment-induced loss of a DNA fragment. The six polymorphisms resulting from the loss of a major fragment were all due to ambient-temperature seed storage. Results were reproducibly obtained from multiple DNA isolations using three separate DNA isolation procedures involving either multiple seed or a single seed as the template source. Therefore, genetically identical seed can consistently display RAPD polymorphisms as a response to the environmental exposure.
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Zhai, Liu-Tao, Stephane Rety, Wei-Fei Chen, Ze-Yu Song, Daniel Auguin, Bo Sun, Shuo-Xing Dou, and Xu-Guang Xi. "Crystal structures of N-terminally truncated telomerase reverse transcriptase from fungi." Nucleic Acids Research 49, no. 8 (April 15, 2021): 4768–81. http://dx.doi.org/10.1093/nar/gkab261.

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Abstract Telomerase plays critical roles in cellular aging, in the emergence and/or development of cancer, and in the capacity for stem-cell renewal, consists of a catalytic telomerase reverse transcriptase (TERT) and a template-encoding RNA (TER). TERs from diverse organisms contain two conserved structural elements: the template-pseudoknot (T-PK) and a helical three-way junction (TWJ). Species-specific features of the structure and function of telomerase make obtaining a more in-depth understanding of the molecular mechanism of telomerase particularly important. Here, we report the first structural studies of N-terminally truncated TERTs from Candida albicans and Candida tropicalis in apo form and complexed with their respective TWJs in several conformations. We found that Candida TERT proteins perform only one round of telomere addition in the presence or absence of PK/TWJ and display standard reverse transcriptase activity. The C-terminal domain adopts at least two extreme conformations and undergoes conformational interconversion, which regulates the catalytic activity. Most importantly, we identified a conserved tertiary structural motif, called the U-motif, which interacts with the reverse transcriptase domain and is crucial for catalytic activity. Together these results shed new light on the structure and mechanics of fungal TERTs, which show common TERT characteristics, but also display species-specific features.
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35

Ansari, M. Z., and A. Mujeeb. "Modeling of laser speckles of heterogeneous dynamics in drying and aging paint dispersions using a view-based temporal template method." Laser Physics 28, no. 8 (June 7, 2018): 085603. http://dx.doi.org/10.1088/1555-6611/aabed4.

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Komalasari, Maya, and Bambang Sunendar. "Synthesis and Characterization of TiO2 Nanoparticle Using Starch as a Template by Sol-Gel Method for the Application of UV Protection." Advanced Materials Research 789 (September 2013): 237–41. http://dx.doi.org/10.4028/www.scientific.net/amr.789.237.

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Nanotechnology is one of the key technology had been developed since in all fields including textile industries for medical, hygienic, and technical textiles. Particle size with nanohad been indicated in particular for the application of controlled release material for functional textiles. TiO2nanopowder has remarkable photo-catalytic and semiconductor as material for various advanced technology fields of application such as UV Protection. In this research the synthesis of TiO2nanoparticle and characterization had been conducted successfully by sol-gel method. The starch was used as a template to get nanoparticles structure. TiO2sol with narrow particle size distribution using TiCl4as the starting material. The sol was prepared by a process where HCl was added to a gel of hydrated titanium oxide to dissolve it. The effect of preparation parameters were investigated, by deionized water : HCl 1 M was slowly added to TiCl4at 5 °C. In this study the production of anatase or rutile TiO2nanostructured powder by forced hydrolysis of aqueous Ti (IV) chloride solution and concentration from 0,3, 0,5 then 1 M. TiO2sphere were fabricated by a facile and low cost stable starch assisted by sol-gel method. Aqueous solution of starch was added and then heated in temperature 80°C and aqueous solution of ammonium hydroxide was added to adjust pH to 8. After aging period of time, the white precipitate was filtered and then calcined in temperature 5000C. The as-obtained samples were characterize,kjnhjd by SEM (Scanning Electron Microscope), UV-vis diffuse reflectance spectroscopy, X-Ray Diffraction (XRD) and Brunauer Emmett Teller (BET) analysis. The particle size is less than 100 nm and if it uses template particle TiO2more uniform distribution and spherical shape with particle size 170 200 nm. Crystalinity particle is 4 19 nm and the phase structure of anatase and rutile. The energy band gap semiconductor TiO2synthesis is 3.1 to 3.7 eV. Surface area without template starch 40.655 m2/g, with total for volume 0.278 cm3/g and pore size of 27 nm, and used template starch surface area 35.488m2/g with total for volume 0.196 cm3/g and pore size of 22 nm. Based on this research, the best a crystal phase for UV protection application is rutile phase.
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Thovicha, Mananya, and Varong Pavarajarn. "Fabrication of Mesoporous Titanium Dioxide Assisted by Resorcinol/Formaldehyde Gel." ASEAN Journal of Chemical Engineering 11, no. 1 (August 5, 2011): 28. http://dx.doi.org/10.22146/ajche.50041.

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Mesoporous structures of materials have attracted considerable attention recently because of their potential in a variety of applications. In this work, resorcinol/formaldehyde (RF) gel was used as a template for the synthesis of mesoporous titania, which is in great interest in catalysis, photocatalysis, gas sensor and photovoltaic applications. RF-gel was prepared by the sol-gel polycondensation of resorcinol (R) and formaldehyde (F). Titanium tetraisopropoxide (TTIP) was used as precursor for titania. However, direct incorporation of TTIP into RF-gel was limited by a spontaneous reaction between TTIP and RF gel, which consequently resulted in rapid solidification of the gel. Titania sol was firstly prepared from TTIP via sol-gel process. After certain period of aging time, the titania sol was added into RF mixture, which had been aged for predetermined period of time as well. After that, the mixture was further aged for another 36 hours before being dried at 80°C. Finally, the dried gel was calcined at 500°C for 4 hours to remove the RF template. The obtained titania powders were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), surface area measurement via nitrogen adsorption, and Fourier transform infrared spectroscopy (FTIR). The specific surface area of the samples was in the range of 30-33 m2/g. and the average diameter of about 8.8-37.7 nm. It was found that the rate of addition for titania sol into the RF-gel had influence on the phase of the final product. The increased rate favored the formation of titania in rutile phase.
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Park, Juyoung, Kyong Hee Chee, and Angelica Yeh. "Life Course Themes in Japanese Americans’ Dementia Care Profiles." Innovation in Aging 4, Supplement_1 (December 1, 2020): 542. http://dx.doi.org/10.1093/geroni/igaa057.1763.

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Abstract The “Faces of Caregiving” video project highlights the social and cultural aspects of dementia care as shared by seven Japanese Americans. We performed a content analysis of the narratives in the videos, and prominent themes included stigma, gender, resilience, and values placed on family and community. We also applied the life course perspective in examining each care trajectory and found the principles of historical time, linked lives, timing, and human agency to be not only relevant but also useful for a comprehensive understanding of the shared and unique care experiences of Japanese Americans. These results have significant practical implications in that they inform a conceptual template for developing similar video projects for other Asian ethnic groups in the United States. The video project can be replicated within an appropriate cultural context, and such a culturally sensitive approach can help better meet diverse ethnic minorities’ unmet needs for information and education. Part of a symposium sponsored by the Aging Among Asians Interest Group.
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Pilzecker, Bas, Olimpia Alessandra Buoninfante, Paul van den Berk, Cesare Lancini, Ji-Ying Song, Elisabetta Citterio, and Heinz Jacobs. "DNA damage tolerance in hematopoietic stem and progenitor cells in mice." Proceedings of the National Academy of Sciences 114, no. 33 (July 31, 2017): E6875—E6883. http://dx.doi.org/10.1073/pnas.1706508114.

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DNA damage tolerance (DDT) enables bypassing of DNA lesions during replication, thereby preventing fork stalling, replication stress, and secondary DNA damage related to fork stalling. Three modes of DDT have been documented: translesion synthesis (TLS), template switching (TS), and repriming. TLS and TS depend on site-specific PCNA K164 monoubiquitination and polyubiquitination, respectively. To investigate the role of DDT in maintaining hematopoietic stem cells (HSCs) and progenitors, we used PcnaK164R/K164R mice as a unique DDT-defective mouse model. Analysis of the composition of HSCs and HSC-derived multipotent progenitors (MPPs) revealed a significantly reduced number of HSCs, likely owing to increased differentiation of HSCs toward myeloid/erythroid-associated MPP2s. This skewing came at the expense of the number of lymphoid-primed MPP4s, which appeared to be compensated for by increased MPP4 proliferation. Furthermore, defective DDT decreased the numbers of MPP-derived common lymphoid progenitor (CLP), common myeloid progenitor (CMP), megakaryocyte-erythroid progenitor (MEP), and granulocyte-macrophage progenitor (GMP) cells, accompanied by increased cell cycle arrest in CMPs. The HSC and MPP phenotypes are reminiscent of premature aging and stressed hematopoiesis, and indeed progressed with age and were exacerbated on cisplatin exposure. Bone marrow transplantations revealed a strong cell intrinsic defect of DDT-deficient HSCs in reconstituting lethally irradiated mice and a strong competitive disadvantage when cotransplanted with wild-type HSCs. These findings indicate a critical role of DDT in maintaining HSCs and progenitor cells, and in preventing premature aging.
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Nawog, Methodius Anak, Mohd Nazlan Mohd Muhid, Nik Ahmad Nizam Nik Malek, and Halimaton Hamdan. "Eco-Friendly Synthesis of Nanozeolite NaA from Rice Husk Ash and its Efficiency in Removing Ammonium Ions." Key Engineering Materials 594-595 (December 2013): 168–72. http://dx.doi.org/10.4028/www.scientific.net/kem.594-595.168.

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The eco-friendly synthesis of nanozeolite need to be developed in order to minimize the consumption of unwanted excess extracted solutions or solvents and maximize the utilization of beneficial wastes as its raw materials. Thus, the synthesis of nanozeolite NaA from rice husk ash (RHA) without extraction of silica from RHA and without organic template has been successfully achieved. Nanozeolite NaA was synthesized from rice husk ash (RHA) via this main step: aging the aluminosilicate suspension (3.190 Na2O: Al2O3: 1.4SiO2:235.07H2O) for 3 days at room temperature with agitation rate of 150 rpm followed by heating at 55 °C for 18 hours. The nanozeolite NaA was confirmed by XRD, FTIR, FESEM and particle size distribution analysis where the highest particle size was in the range of 100 to 400 nm. Its efficiency in removing ammonium ions in aqueous solution was found to be better than that of microsized zeolite NaA thus proved that the lower particle sizes of zeolite NaA (nanosize) tended to have higher adsorption sites and higher exchange capacity.
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Canham, Sarah, Joe Humphries, Victoria Burns, Tamara Sussman, and Christine Walsh. "Uncovering Promising Practices for Supporting Older People Experiencing Homelessness." Innovation in Aging 4, Supplement_1 (December 1, 2020): 708. http://dx.doi.org/10.1093/geroni/igaa057.2489.

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Abstract Montréal, Calgary, and Vancouver have seen a dramatic increase in homelessness among adults aged 50+. In order to identify ‘promising practices’ that promote aging-in-the-right-place for older people experiencing homelessness (OPEH) in Montréal, Calgary, and Vancouver, we conducted an environmental scan and three World Café workshops with 99 service providers and OPEH. We identified 53 promising practices managed or operated by 42 providers which we categorized across a shelter/housing continuum: 1) Emergency/transitional/temporary shelter/housing; 2) Independent housing with offsite supports; 3) Supported independent housing with onsite, non-medical supports; 4) Permanent supportive housing with onsite medical support and/or specialized services; 5) Long-term care; and 6) Palliative care/hospice. Study findings provide a template for existing solutions to the diverse shelter/housing needs of OPEH and insight into the gaps in shelter/housing and services that would support OPEH to age-in-the-right place. Policy and practice implications for scaling promising practices will be discussed. Part of a symposium sponsored by the Environmental Gerontology Interest Group.
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42

Tanniru, Mohan R., Nimit Agarwal, Amanda Sokan, and Salim Hariri. "An Agile Digital Platform to Support Population Health—A Case Study of a Digital Platform to Support Patients with Delirium Using IoT, NLP, and AI." International Journal of Environmental Research and Public Health 18, no. 11 (May 26, 2021): 5686. http://dx.doi.org/10.3390/ijerph18115686.

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For an organization to be customer centric and service oriented requires that it use each encounter with a customer to create value, leverage advanced technologies to design digital services to fulfill the value, and assess perceived value-in-use to continue to revise the value as customer expectations evolve. The adaptation of value cycles to address the rapid changes in customer expectations requires agile digital platforms with dynamic software ecosystems interacting with multiple actors. For public health agencies focused on population health, these agile digital platforms should provide tailored care to address the distinct needs of select population groups. Using prior research on aging and dynamic software ecosystems, this paper develops a template for the design of an agile digital platform to support value cycle activities among clinical and non-clinical actors, including population groups. It illustrates the design of an agile digital platform to support clients that suffer from delirium, using digital services that leverage Internet of Things, natural language processing, and AI that uses real-time data for learning and care adaption. We conclude the paper with directions for future research.
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43

Liu, Peter Y., Steven M. Pincus, Daniel M. Keenan, Ferdinand Roelfsema, and Johannes D. Veldhuis. "Analysis of bidirectional pattern synchrony of concentration-secretion pairs: implementation in the human testicular and adrenal axes." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 288, no. 2 (February 2005): R440—R446. http://dx.doi.org/10.1152/ajpregu.00414.2004.

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The hypothalamo-pituitary-testicular and hypothalamo-pituitary-adrenal axes are prototypical coupled neuroendocrine systems. In the present study, we contrasted in vivo linkages within and between these two axes using methods without linearity assumptions. We examined 11 young (21–31 yr) and 8 older (62–74 yr) men who underwent frequent (every 2.5 min) blood sampling overnight for paired measurement of LH and testosterone and 35 adults (17 women and 18 men; 26–77 yr old) who underwent adrenocorticotropic hormone (ACTH) and cortisol measurements every 10 min for 24 h. To mirror physiological interactions, hormone secretion was first deconvolved from serial concentrations with a waveform-independent biexponential elimination model. Feedforward synchrony, feedback synchrony, and the difference in feedforward-feedback synchrony were quantified by the cross-approximate entropy (X-ApEn) statistic. These were applied in a forward (LH concentration template, examining pattern recurrence in testosterone secretion), reverse (testosterone concentration template, examining pattern recurrence in LH secretion), and differential (forward minus reverse) manner, respectively. Analogous concentration-secretion X-ApEn estimates were calculated from ACTH-cortisol pairs. X-ApEn, a scale- and model-independent measure of pattern reproducibility, disclosed 1) greater testosterone-LH feedback coordination than LH-testosterone feedforward synchrony in healthy men and significant and symmetric erosion of both feedforward and feedback linkages with aging; 2) more synchronous ACTH concentration-dependent feedforward than feedback drive of cortisol secretion, independent of gender and age; and 3) enhanced detection of bidirectional physiological regulation by in vivo pairwise concentration-secretion compared with concentration-concentration analyses. The linking of relevant biological input to output signals and vice versa should be useful in the dissection of the reciprocal control of neuroendocrine systems or even in the analysis of other nonendocrine networks.
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Zhong, Ming, Yanqiang Zhang, Xi Yang, Yufeng Yao, Junlong Guo, Yaping Wang, and Yaxin Liu. "Assistive Grasping Based on Laser-point Detection with Application to Wheelchair-mounted Robotic Arms." Sensors 19, no. 2 (January 14, 2019): 303. http://dx.doi.org/10.3390/s19020303.

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As the aging of the population becomes more severe, wheelchair-mounted robotic arms (WMRAs) are gaining an increased amount of attention. Laser pointer interactions are an attractive method enabling humans to unambiguously point out objects and pick them up. In addition, they bring about a greater sense of participation in the interaction process as an intuitive interaction mode. However, the issue of human–robot interactions remains to be properly tackled, and traditional laser point interactions still suffer from poor real-time performance and low accuracy amid dynamic backgrounds. In this study, combined with an advanced laser point detection method and an improved pose estimation algorithm, a laser pointer is used to facilitate the interactions between humans and a WMRA in an indoor environment. Assistive grasping using a laser selection consists of two key steps. In the first step, the images captured using an RGB-D camera are pre-processed, and then fed to a convolutional neural network (CNN) to determine the 2D coordinates of the laser point and objects within the image. Meanwhile, the centroid coordinates of the selected object are also obtained using the depth information. In this way, the object to be picked up and its location are determined. The experimental results show that the laser point can be detected with almost 100% accuracy in a complex environment. In the second step, a compound pose-estimation algorithm aiming at a sparse use of multi-view templates is applied, which consists of both coarse- and precise-matching of the target to the template objects, greatly improving the grasping performance. The proposed algorithms were implemented on a Kinova Jaco robotic arm, and the experimental results demonstrate their effectiveness. Compared with commonly accepted methods, the time consumption of the pose generation can be reduced from 5.36 to 4.43 s, and synchronously, the pose estimation error is significantly improved from 21.31% to 3.91%.
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MENG, Chunxia, and Jin HOU. "Modified Phillipsite as a Novel Ion-Exchanger for Potassium Extraction from Seawater." Materials Science 25, no. 4 (June 27, 2019): 441–45. http://dx.doi.org/10.5755/j01.ms.25.4.19961.

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Template-free preparation of phillipsite as a novel K+ ion-exchanger was studied systematically by hydrothermal synthesis. The alkalinity, dosage of water glass, dosage of H2O, aging time, reaction temperature and time of hydrothermal synthesis were discussed in detail. The optimized material obtained about phillipsite through the synthesis and testing methods was performed. The K+ ion-exchange capacity and selectivity coefficient were tested. The molar composition for preparing high performance phillipsite obtained was 2K2O:18SiO2:Al2O3:510H2O by optimizing synthetic conditions. The K+ ion-exchange capacity of phillipsite was 57.3 mg/g in seawater. The K+ selectivity coefficient was 88.6 in an equimolar K+ and Na+ mixed solution. Phillipsite can selectively capture K+ over other ions, and therefore can be used for potassium extraction selectively from seawater. Phillipsite was characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM) and energy-dispersive X-ray spectroscopy (EDS). The XRD pattern indicated that the synthetic zeolite was phillipsite. The phillipsite particles exhibited cross-like shape and the average particle size was about 2.5 μm. The synthetic phillipsite was mainly consisted of Si, Al, K and O elements.
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Lv, Qiming, Mingchao Yan, Xiangyu Shen, Jing Wu, Wenwen Yu, Shengyao Yan, Feng Yang, et al. "Normative Analysis of Individual Brain Differences Based on a Population MRI-Based Atlas of Cynomolgus Macaques." Cerebral Cortex 31, no. 1 (August 26, 2020): 341–55. http://dx.doi.org/10.1093/cercor/bhaa229.

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Abstract The developmental trajectory of the primate brain varies substantially with aging across subjects. However, this ubiquitous variability between individuals in brain structure is difficult to quantify and has thus essentially been ignored. Based on a large-scale structural magnetic resonance imaging dataset acquired from 162 cynomolgus macaques, we create a species-specific 3D template atlas of the macaque brain, and deploy normative modeling to characterize individual variations of cortical thickness (CT) and regional gray matter volume (GMV). We observed an overall decrease in total GMV and mean CT, and an increase in white matter volume from juvenile to early adult. Specifically, CT and regional GMV were greater in prefrontal and temporal cortices relative to early unimodal areas. Age-dependent trajectories of thickness and volume for each cortical region revealed an increase in the medial temporal lobe, and decreases in all other regions. A low percentage of highly individualized deviations of CT and GMV were identified (0.0021%, 0.0043%, respectively, P &lt; 0.05, false discovery rate [FDR]-corrected). Our approach provides a natural framework to parse individual neuroanatomical differences for use as a reference standard in macaque brain research, potentially enabling inferences regarding the degree to which behavioral or symptomatic variables map onto brain structure in future disease studies.
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Forde, Patrick M., Kitty Violette, Karen Maylor, Barbara Kasecamp, Beth Rushworth, Cheryl Jefferson, Joan Wilmore, et al. "Structured approach to improving wait times and overall customer service in an oncology outpatient phlebotomy department." Journal of Clinical Oncology 31, no. 31_suppl (November 1, 2013): 77. http://dx.doi.org/10.1200/jco.2013.31.31_suppl.77.

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77 Background: Demands on the Johns Hopkins phlebotomy service have increased exponentially over the past several years leading to increased patient (pt) waiting times and reduced patient and staff satisfaction. Methods: The goal of our project was to reduce waiting times for outpatient phlebotomy to <30 mins for 90% of pts by May 2013 using a multi-disciplinary lean sigma approach. The following interventions were implemented - Two weekly multidisciplinary lean sigma meetings; Move to set appointment times; Twice daily staff "huddles" to plan the work schedule; Ensure a minimum of 8 phlebotomists on duty daily; Expand training for clinical assistants (CAs) to access VADs; Introduce pager system for pts to reduce needless waiting; Introduce leadership positions among phlebotomy and CA staff to manage change. Results: Within 6 months of these concerted efforts wait times have reduced to <30 mins and patient satisfaction scores for >90% of pts are very good or excellent. Conclusions: Difficult problems such as increasing patient demand with constrained resources can be ameliorated with a multidisciplinary structured approach. The project as outlined may serve as a template for other oncology services dealing with the increasing demands of an aging population in a time of increasingly limited resources.
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48

Shefer, Kinneret, Yogev Brown, Valentin Gorkovoy, Tamar Nussbaum, Nikolai B. Ulyanov, and Yehuda Tzfati. "A Triple Helix within a Pseudoknot Is a Conserved and Essential Element of Telomerase RNA." Molecular and Cellular Biology 27, no. 6 (January 8, 2007): 2130–43. http://dx.doi.org/10.1128/mcb.01826-06.

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ABSTRACT Telomerase copies a short template within its integral telomerase RNA onto eukaryotic chromosome ends, compensating for incomplete replication and degradation. Telomerase action extends the proliferative potential of cells, and thus it is implicated in cancer and aging. Nontemplate regions of telomerase RNA are also crucial for telomerase function. However, they are highly divergent in sequence among species, and their roles are largely unclear. Using in silico three-dimensional modeling, constrained by mutational analysis, we propose a three-dimensional model for a pseudoknot in telomerase RNA of the budding yeast Kluyveromyces lactis. Interestingly, this structure includes a U-A·U major-groove triple helix. We confirmed the triple-helix formation in vitro using oligoribonucleotides and showed that it is essential for telomerase function in vivo. While triplex-disrupting mutations abolished telomerase function, triple compensatory mutations that formed pH-dependent G-C·C+ triples restored the pseudoknot structure in a pH-dependent manner and partly restored telomerase function in vivo. In addition, we identified a novel type of triple helix that is formed by G-C·U triples, which also partly restored the pseudoknot structure and function. We propose that this unusual structure, so far found only in telomerase RNA, provides an essential and conserved telomerase-specific function.
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Lee, Yeong-Bae, and Chang-Ki Kang. "Cerebrovascular Reactivity Assessment during Carbon Dioxide Inhalation Using SPECT." Applied Sciences 11, no. 3 (January 27, 2021): 1161. http://dx.doi.org/10.3390/app11031161.

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Background: Perfusion single-photon emission computed tomography (SPECT) using an acetazolamide is an important clinical tool used to assess cerebrovascular reactivity (CVR) in patients, but its use has been limited to clinical diagnostics. This study aimed to preliminarily evaluate the feasibility of perfusion SPECT using carbon dioxide (CO2). Methods: Ten healthy subjects participated in two consecutive SPECT scans using CO2 inhalation. To evaluate brain perfusion after preprocessing, the voxel-by-voxel CVR values were averaged in 13 subgroup regions of interest (ROIs) based on a template. Subsequently, averaged CVR values of each ROI were analyzed based on both cerebellar hemispheres. Results: CVR values in the eight subgroup ROIs, which included vermis, both insula/cingulate, and frontal cortices, showed significant changes (p < 0.05). CVR values were higher in vermis and right insula/cingulate by 3.34% and 3.15%, respectively. Conclusions: This study showed that quantitative SPECT with CO2 inhalation could be used to evaluate the voxel-based CVR in healthy subjects, which could be beneficial for elucidating induced hypercapnic states and for longitudinally investigating the healthy aging in brain vessels. Furthermore, the cerebrovascular hemodynamic parameters induced by CO2 could play an important role as a biomarker to evaluate treatment progress in patients with cerebrovascular disease.
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Maulitiva Untoro, Yovilianda, Diaz Ayu Widyasari, Edi Supriadi, and Siti Nurul Aisyiyah Jenie. "The Effect of Rhodamine B on The Properties of Fluorescent Nanoparticles Derived from Geothermal Silica." Journal of Pure and Applied Chemistry Research 9, no. 3 (December 31, 2020): 171–76. http://dx.doi.org/10.21776/ub.jpacr.2020.009.03.524.

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Abstract:
Rhodamine B can be used as a fluorophore to produce fluorescent silica nanoparticles derived from geothermal sludge. The purpose of this research is to synthesize fluorescent silica nanoparticles (FSNP) modified with rhodamine B and cetyl trimethyl ammonium bromide (CTAB) using sol-gel method. Geothermal waste was used as a precursor and added with NaOH at 900C to generate sodium silicate. Rhodamine B, as the fluorescent dye were added with concentration variations ranging from 0.156 mg/g to 10 mg/g.CTAB was used as template and HCl 2N was applied as gelling catalyst with aging time of 18 hours. Characterization of FSNP was measured using spectrofluorometer to identify the fluorescent intensity, fourier transform infrared (FT-IR) to determine the functional group of FSNP, Brauner-Emmett-Teller (BET) adsorption to calculate the specific area of the particles, X-ray diffraction (XRD) to analyze the crystallographic phases, and transmission electron microscopy (TEM) to analyze the surface morphology of the FSNP. FT-IR and fluorescent intensity results showed that FSNP with 2.5 mg/g of rhodamine B had the optimum characteristics. The FSNP was in amorphous phase with uniform pore distribution. BET analysis showed that the specific surface of the FSNP was 190.22 m2/g.
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