Journal articles: 'Ten-t'

1

Bean, Charles, and James Symons. "Ten Years of Mrs. T." NBER Macroeconomics Annual 4 (January 1989): 13–61. http://dx.doi.org/10.1086/654096.

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Steinau, H. U., B. Clasbrummel, C. Josten, H. H. Homann, M. Lehnhardt, and D. Druecke. "Operative Interdisziplinarit�t?Extremit�ten." Der Chirurg 75, no. 4 (April 1, 2004): 390–98. http://dx.doi.org/10.1007/s00104-004-0852-6.

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3

Schaser, K. D., I. Melcher, U. Settmacher, and N. P. Haas. "Operative Interdisziplinarit�t?Extremit�ten." Der Chirurg 75, no. 4 (April 1, 2004): 399–410. http://dx.doi.org/10.1007/s00104-004-0866-0.

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4

Parker, J. Stephen. "Ten Years of Information Developmen t." Information Development 11, no. 1 (March 1995): 1–5. http://dx.doi.org/10.1177/026666699501100101.

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5

Nordhaus, William D. "[Ten Years of Mrs. T.]: Comment." NBER Macroeconomics Annual 4 (January 1989): 61–67. http://dx.doi.org/10.1086/654097.

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6

Eltis, Walter. "[Ten Years of Mrs. T.]: Comment." NBER Macroeconomics Annual 4 (January 1989): 67–71. http://dx.doi.org/10.1086/654098.

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7

Chlomoudis, Constantinos, Petros Pallis, and Charalampos Platias. "Environmental Mainstreaming in Greek TEN-T Ports." Sustainability 14, no. 3 (January 30, 2022): 1634. http://dx.doi.org/10.3390/su14031634.

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Along with recent fundamental changes in several aspects of the port industry, ports come up against formidable environmental challenges. It is thus important and often imperative to mainstream environmental concerns in their operation, planning, and development; improve their environmental performance; and make the transition to sustainable production and consumption patterns. The industry’s greening is largely underpinned by European Union (EU) transport and port policy, with major European initiatives such as the Trans-European Transport Network (TEN-T), the European Green Deal, and Blue Growth expected to give new impetus. This paper examines environmental mainstreaming in Greek TEN-T ports and their ability to cope with upcoming challenges based on questionnaire responses by 23 port authorities and taking into account the relevant progress made by ESPO port members. We argue that all respondents have gradually become aware of the need to move towards an environment-friendly operation and development, but progress is slow, and there is still a lot to be done. Performances vary and depend on different factors, while ports are faced with significant challenges and various constraints. Nevertheless, new environmental standards present a real opportunity for Greek ports to undertake deep structural changes, especially in view of current and future European port policy.

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8

Loughran, Thomas P. "Ten Best Readings on T-Cell Lymphoid Malignancies." Cancer Control 5, no. 1 (January 1998): 1. http://dx.doi.org/10.1177/107327489800500108.

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Raczyński, Jan, Bużałek, Tomasz, and Pomykała, Agata. "Koncepcja integracji węzłów łódzkiego i kieleckiego sieci TEN-T." Problemy Kolejnictwa - Railway Reports, no. 180 (September 2018): 49–60. http://dx.doi.org/10.36137/1806p.

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10

Janoš, Vít, and Milan Kríž. "INFRASTRUCTURE PARAMETERS AFFECTING CAPACITY OF RAILWAYS IN TEN-T." Acta Polytechnica CTU Proceedings 5 (September 15, 2016): 22. http://dx.doi.org/10.14311/app.2016.5.0022.

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The article presents possible solutions of the issue of the lost capacity on a double-track line. It is shown a solution where an inserted train on the double-track line use the lost capacity of the opposite line track using active overtaking. The feasibility of such a solution is discussed and the length of sections suitable for active overtaking is calculated.

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11

Raczyński, Jan, Bużałek, Tomasz, and Pomykała, Agata. "Concept of Integrating the Łódź and Kielce TEN-T Hubs." Problemy Kolejnictwa - Railway Reports, no. 180 (September 2018): 121–32. http://dx.doi.org/10.36137/1806e.

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12

Goldmann, Kathrin, and Jan Wessel. "TEN-T corridors – Stairway to heaven or highway to hell?" Transportation Research Part A: Policy and Practice 137 (July 2020): 240–58. http://dx.doi.org/10.1016/j.tra.2020.04.010.

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13

Sokol, Lubomir, and L. Frank Glass. "Ten Best Readings Relating to T/NK-Cell Lymphomas/Leukemias." Cancer Control 14, no. 2 (April 2007): 192. http://dx.doi.org/10.1177/107327480701400214.

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14

Siewiera, Grzegorz. "Budowa i modernizacja linii kolejowych w ramach sieci TEN-T." Rail Vehicles, no. 3 (August 2, 2009): 43–47. http://dx.doi.org/10.53502/rail-139762.

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15

Shinkawa, A., S. Ohnishi, F. Hamanaka, and Y. Kurioka. "Evaluation of odor quality using semantic differential method for ten odorants of T & T olfactometer." Japanese journal of ergonomics 31, Supplement (1995): 532–33. http://dx.doi.org/10.5100/jje.31.supplement_532.

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16

Kurioka, Y., A. Shinkawa, and S. Ohnishi. "Evaluation of odor quality for ten odorants of T&T olfactometer using concrete 28 adjectives." Japanese journal of ergonomics 32, Supplement (1996): 252–53. http://dx.doi.org/10.5100/jje.32.supplement_252.

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17

Jenkins, Stephen H. "Feeding the Ten Billion: Plants and Population Growth. L. T. Evans." Quarterly Review of Biology 75, no. 2 (June 2000): 220. http://dx.doi.org/10.1086/393480.

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18

Bottcher, Boris. "The Trans-European Transport Network (Ten-T): History, Progress and Financing." Communications - Scientific letters of the University of Zilina 8, no. 1 (March 31, 2006): 51–54. http://dx.doi.org/10.26552/com.c.2006.1.51-54.

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19

RONG, HUA, YIPING WANG, and HOUHUN LI. "Review of the genus Termioptycha Meyrick, 1889 (Lepidoptera, Pyralidae) from China, with descriptions of four new species." Zootaxa 4329, no. 2 (October 3, 2017): 159. http://dx.doi.org/10.11646/zootaxa.4329.2.3.

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The genus Termioptycha Meyrick, 1889 from China is reviewed. Among the ten species studied, T. longiclavata sp. nov., T. longispina sp. nov., T. nigrimacularis sp. nov. and T. cornutitrifurca sp. nov. are described as new; T. conjuncta (Warren, 1896), comb. rev. is re-allocated in this genus from Salma Walker, 1863; and T. conjuncta and T. eucarta (Felder & Rogenhofer, 1875) are newly recorded in China. Photographs of adults and genitalia are provided. A key to the ten species in China based on male genitalia is provided.

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20

Raben, Dorota. "Development of Polish Seaports Infrastructure as a Precondition for Development of Intermodal Transport within the Core TEN-T Corridors." Zeszyty Naukowe Uniwersytetu Szczecińskiego Problemy Transportu i Logistyki 34 (2016): 177–84. http://dx.doi.org/10.18276/ptl.2016.34-17.

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21

van Weenen, Rob Leeuw, Arnaud Burgess, and Jan Francke. "Study on the Implementation of the TEN-T Regulation – The Netherlands Case." Transportation Research Procedia 14 (2016): 484–93. http://dx.doi.org/10.1016/j.trpro.2016.05.101.

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22

Aparicio, Ángel. "The changing decision-making narratives in 25 years of TEN-T policies." Transportation Research Procedia 25 (2017): 3715–24. http://dx.doi.org/10.1016/j.trpro.2017.05.223.

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23

Lee, Whanbong, and Jungnam Kwon. "Ten-year experience on common bile duct exploration without T-tube insertion." Korean Journal of Hepato-Biliary-Pancreatic Surgery 17, no. 2 (2013): 70. http://dx.doi.org/10.14701/kjhbps.2013.17.2.70.

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Böll, Boris, Marion Subklewe, and Michael von Bergwelt-Baildon. "Ten things the hematologist wants you to know about CAR-T cells." Intensive Care Medicine 46, no. 6 (March 30, 2020): 1243–45. http://dx.doi.org/10.1007/s00134-020-06002-9.

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25

Bl�her, Stefan. "Wie langlebig ist die Solidarit�t? Generationsbeziehungen in den sp�ten Lebensjahren." Zeitschrift f�r Gerontologie und Geriatrie 36, no. 2 (April 1, 2003): 110–14. http://dx.doi.org/10.1007/s00391-003-0138-5.

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26

Ibáñez, Juan Nicolás, and Francesco Rotoli. "Measuring the Impact of the Trans-European Road Transport Network on the Accessibility of European Urban Agglomerations." Transportation Research Record: Journal of the Transportation Research Board 2605, no. 1 (January 2017): 72–82. http://dx.doi.org/10.3141/2605-07.

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Transport infrastructure investment is a catalyst for enhanced competitiveness and economic growth through an overall reduction in travel times and costs. These efficiency gains are among the goals of the Trans-European Transport Network (TEN-T) program, one of the major European Union infrastructure policy packages. This study evaluated the benefits of TEN-T with respect to increased accessibility for the population that it encompassed and by using a detailed and up-to-date representation of the entire European road network. A routing algorithm that could efficiently exploit the high detail of the road network was used. By considering various impedance functions in outreach opportunities, the proposed methodology compared, for all major European urban agglomerations considered (695 in total), two measures of accessibility: one baseline measure that considered the TEN-T network as implemented in 2014 and one scenario measure that considered that the whole TEN-T network was completed. The proposed methodology addressed self-accessibility by considering a weighted travel time of the entire road network within each urban agglomeration under study. The results show where the major benefits (accessibility gains) are expected to occur following the completion of the TEN-T policy. In general, the main positive effects are to appear in European areas that are lagging behind in infrastructure investment (Eastern Europe) and in their neighboring counterparts (Central Europe). The presented quantitative estimates may be useful for an eventual review of the focus of and priority for the not-yet-implemented part of TEN-T policy.

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27

Khúlová, Lucia, and Lenka Šprochová. "Importance of TEN-T Corridors in the Development of Infrastructure Example of Visegrad Group Countries." Studia Commercialia Bratislavensia 9, no. 33 (June 1, 2016): 49–57. http://dx.doi.org/10.1515/stcb-2016-0005.

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Abstract Transport is one of key factors of the development of each modern society. It is one of the most important areas that governments all around the world should address when developing national policy. The objective of the article is to define the importance of Trans-European Network - Transport (TEN-T) corridors in the development of infrastructure connections between groups of countries known as Visegrad group. TEN-T core network represents a trans-European transport system and includes the priority area of transport infrastructure. Individual Member States are obliged to complete the TEN-T core on its territory not later than 31.12.2030. The Visegrad group countries as neighbourhood countries presents perspective platform for cooperation in infrastructure development.

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28

Grzelakowski, Andrzej. "European Added Value of the TEN-T Corridors. Basic Research Needs and Challenges." TransNav, the International Journal on Marine Navigation and Safety of Sea Transportation 11, no. 2 (2017): 123–28. http://dx.doi.org/10.12716/1001.11.02.14.

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29

NAKAO, Hideto, Nobutaro BAN, Kazuo OTSUKA, Masataka MORI, Mikio KAWAMOTO, Kenichiro KINOSHITA, Makoto ICHINOSE, and Hideharu FUJII. "A case of chronic adult T-cell leukemia with ten-year clinical course." Nihon Naika Gakkai Zasshi 76, no. 12 (1987): 1876–80. http://dx.doi.org/10.2169/naika.76.1876.

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30

Väkevä, L., A. Ranki, and S. Hahtola. "Ten-year Experience of Bexarotene Therapy for Cutaneous T-cell Lymphoma in Finland." Acta Dermato Venereologica 92, no. 3 (2012): 258–63. http://dx.doi.org/10.2340/00015555-1359.

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31

Wildner, Manfred, Andreas Markuzzi, Waldtraut Casper, and Karl E. Bergmann. "Disparit�ten der Krankenhaus-Fatalit�t nach proximalen Femurfrakturen in der DDR 1989." Sozial- und Pr�ventivmedizin SPM 43, no. 2 (March 1998): 80–89. http://dx.doi.org/10.1007/bf01359228.

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32

Shaker, Z., Z. M. Hassan, H. Sohrabpoor, and N. Mosaffa. "The Immunostatus of T Helper and T Cytotoxic Cells in the Patients Ten Years After Exposure to Sulfur Mustard." Immunopharmacology and Immunotoxicology 25, no. 3 (January 2003): 423–30. http://dx.doi.org/10.1081/iph-120024509.

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33

Funai, Tatsuya, Chizuko Tagawa, Osamu Nakagawa, Shun-ichi Wada, Akira Ono, and Hidehito Urata. "Enzymatic formation of consecutive thymine–HgII–thymine base pairs by DNA polymerases." Chemical Communications 56, no. 80 (2020): 12025–28. http://dx.doi.org/10.1039/d0cc04423g.

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34

Butarbutar, Imelda. "PENGARUH BIMBINGAN GURU PENDIDIKAN AGAMA KRISTEN (PAK) TERHADAP MINAT BELAJAR SISWA." Jurnal Suluh Pendidikan 8, no. 2 (September 15, 2020): 97–108. http://dx.doi.org/10.36655/jsp.v8i2.335.

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The purpose of this study was to determine whether there is an effect of Guidance Christian religious education teacher on interest in learning of grade ten public senior high school Lumban Julu 2014/2015 ”. The research method used is quantitative research aims to study the effect of two variables, while the analysis used is to test the correlation hypothesis, namely the Product Moment and the tools used in data collection are to run a closed questionnaire. To determine whether there is the effect of Guidance Christian religious education teacher (X) on interest in learning (Y) of grade ten public senior high school Lumban Julu 2014/2015. the results result of this reseach shows that t = 5.593. To find out the correlation coefficient at a significant level of 5% where the t-table is 0.361, the t-test is used with the criteria t-count> t-table, so the hypothesis is accepted. The results of testing the hypothesis obtained that t = 5.593 turned out to be greater than t-table 0.361 (5.593> 0.361), thus the hypothesis is accepted. So it can be argued that, "There is an effect of guidance Christian religious education teacher on interest in learning of grade ten public senior hight school Lumban Julu 2014/2015.

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35

Drábek, Michal, Vít Janoš, and Zdeněk Michl. "ON OPERATION OF 740 M LONG FREIGHT TRAINS ON CZECH TEN-T RAILWAY NETWORK." Acta Polytechnica CTU Proceedings 5 (September 15, 2016): 12. http://dx.doi.org/10.14311/app.2016.5.0012.

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Regulation (EU) No 1315/2013 defines actual scope of core and comprehensive TEN-T network, including both networks for railway freight transport. For the core network, possibility to operate 740 m long freight trains is required. The aim of this paper is to analyse availability of appropriate overtaking tracks for 740 m long freight trains. Due to ETCS braking curves and odometry, such trains, after ETCS implementation, will require 780-800 m long overtaking tracks. For practical reasons (e.g. bypass lines), whole Czech railway TEN-T network is analysed. The overtaking track, whose occupation means influence on scheduled traffic or threat to boarding passengers, are excluded. The data was collected from station schemes from Collection of Official Requisites for 2015/16 Timetable, issued by SŽDC, Czech state Infrastructure Manager. Most of appropriate tracks are over 800 m long, but their density in the network and in particular directions varies considerably. For freight traffic, gradient of the line is important, so in the resulting figure, there are marked significant peaks for particular lines as well. Czech TEN-T lines are further segmented on the basis of number of tracks and their traffic character. Then, specific issues on overtaking or crossing of 740 m long freight trains are discussed. As a conclusion, for long-term development of Czech TEN-T lines, targeted investment is recommended not only for passenger railway, but also for freight railway. An attractive capacity offer for railway undertakings, which can stimulate freight traffic on European Rail freight corridors, can be represented by network-bound periodic freight train paths with suitable long overtaking tracks outside bottlenecks. After the overtaking by passenger trains, a freight train should run without stop through large node station or a bottleneck area. Before the sections with high gradients, coupling of additional locomotives should be connected with the overtaking process. Next suitable overtaking tracks should be available behind every significant peak of the line.

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36

Iyengar, Kirti, and Sharad D. Iyengar. "The Copper-T 380A IUD: A ten-year alternative to female sterilisation in India." Reproductive Health Matters 8, no. 16 (January 2000): 125–33. http://dx.doi.org/10.1016/s0968-8080(00)90194-0.

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37

Gis, Maciej, Mateusz Bednarski, and Piotr Orliński. "Energy analysis of charging infrastructure for electric vehicles on the TEN-T road network." E3S Web of Conferences 100 (2019): 00018. http://dx.doi.org/10.1051/e3sconf/201910000018.

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Electromobility is a European vision of future motorization. In Poland, there are plans to introduce a million vehicles of this type by 2030. Currently, their share is marginal (about 1 percent). This vision is to be made real. This is due to the fact that vehicle manufacturers are developing newer EV vehicle constructions. Increasing the number of electric vehicles requires the development of their charging infrastructure. Based on the work of the authors regarding the EV vehicle charging network on the Trans-European Transport Network road network, it was possible to extend this issue with energy calculations related to energy demand for supplying the EV vehicle charging network. This is an important topic from the point of view of the State’s energy needs. The calculations made in the article present the problem of the need to increase the production of electricity, which in the case of Poland is associated with increased emissions of harmful substances and the possibility of periodic interruptions in the supply of electricity. Due to excessive domestic consumption with too little production. The second issue is the need to supply electricity to the charging station (infrastructure), as well as transmission losses, which limit the possibility of building multi-station fast charging stations. The issue presented by the authors in this article is one of the key problems relating to the introduction of electromobility in Poland. The key is to determine how large the demand for electricity in the country will be if a greater number of electric vehicles is put into operation. Considering that there are power shortages during a hot summer, this may affect the possibility of using electric vehicles in the country.

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Öberg, Maria, Kristina L. Nilsson, and Charlotta M. Johansson. "Complementary governance for sustainable development in transport: The European TEN-T Core network corridors." Case Studies on Transport Policy 6, no. 4 (December 2018): 674–82. http://dx.doi.org/10.1016/j.cstp.2018.08.006.

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39

Perry, Anamarija M., Roger A. Warnke, Qinglong Hu, Philippe Gaulard, Christiane Copie-Bergman, Serhan Alkan, Huan-You Wang, et al. "Indolent T-cell lymphoproliferative disease of the gastrointestinal tract." Blood 122, no. 22 (November 21, 2013): 3599–606. http://dx.doi.org/10.1182/blood-2013-07-512830.

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Key Points Ten cases of an indolent T-cell lymphoproliferative disease of the gastrointestinal tract are reported. It is important to recognize this condition because it can be mistaken for aggressive T-cell lymphoma, which may lead to unnecessary therapy.

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40

Brown, Ross D., Hayley Suen, Christian E. Bryant, Shihong Yang, James Favaloro, John Gibson, P. Joy Ho, Phillip Fromm, Derek NJ Hart, and Douglas E. Joshua. "Ten Year Survival in Patients with Myeloma Is Characterized by the Persistence of Immunological Control Which Is Detected by Immunological Biomarkers." Blood 120, no. 21 (November 16, 2012): 1818. http://dx.doi.org/10.1182/blood.v120.21.1818.1818.

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Abstract Abstract 1818 There is clinical evidence for the presence of a limited degree of host-tumor control in patients with multiple myeloma (MM) but the exact mechanisms involved are not known. Patients who survive for more than ten years are likely to have the most active immunological host-tumour control and are an ideal cohort to study. We now add to our preliminary observations using a range of immunological biomarkers in the 29 of these patients who attend our clinic. 51% of MM patients (n=264) had expanded CD3+CD8+ TCRVβ+ CD57+T cell clones detected by TCRVβ analysis (Beckman, BetaMark). Clonality was confirmed by IgH CDR3 sequencing. These clones accounted for 14.3% (median) of the CD3 cells (range 4–49%). CFSE tracking demonstrated the anergic nature of these clonal T cells (median 6% proliferation) compared with other CD8 cells (70% proliferation) while Geneset analysis of mRNA microarrays (Affymetrix U133) identified that anergy was caused by upregulated RAS, CSK, TOB and suppressed ERK pathways. Unlike recent reports for T-LGL, microarray analysis suggested that there was no evidence of STAT3 upregulation in the MM T cell clones. Functional studies suggested that these non-proliferating clones have split anergy as interferon-γ production was normal. In contrast, all ten year survivors had expanded T cell clones and serial studies demonstrated a >8 year persistence of the same clone in 8 out of 12 patients studied. More importantly, unlike the other MM patients, the T cell clones in 19 out of 21 of the ten year survivors studied were not anergic. The Treg/Th17 ratio in the ten year survivors was significantly lower than other MM patients (median 1.9 vs 12.0; p<0.0002) and even lower than age matched normals (median 5.6; p<0.006). This difference in the ten year survivors was due to an increased absolute Th17 cell (p<0.005) number and a reduced absolute Tregnumber (p<0.05). MM patients had a reduced number of absolute 6-Sulfo-LacNAc (SLAN)-DCs, a major source of IL-12, compared to both age matched controls and long term survivors (p < 0.01). Allo SLAN-DCs stimulated a higher proliferative response by MM T cells than could be achieved with mononuclear preparations. In conclusion, MM patients have expanded clones of cytotoxic T cells that exhibit split anergy and these cells are potential candidates for restoring immunological control of MM and other cancers. The normalised Treg/Th17 ratio suggests that the induced tolerance associated with increased Treg cell numbers is also absent in these patients. Our observations that the ten year MM survivors do not have anergy in their clonal T cells and have less Treg suppression offers a unique cohort for future studies. Disclosures: No relevant conflicts of interest to declare.

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Iqbal, Omer, Daneyal Syed, Michael Mosier, Julia Malalis, Christine Mata, Amy Lin, Nicole Mitchel, et al. "Immune-Mediated Activation Of Coagulation In Patients With Stevens Johnson Syndrome/Toxic Epidermal Necrolysis." Blood 122, no. 21 (November 15, 2013): 1117. http://dx.doi.org/10.1182/blood.v122.21.1117.1117.

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Abstract Background Stevens Johnson Syndrome/Toxic Epidermal Necrolysis (SJS/TEN) are specific drug hypersensitivity reactions initiated by cytotoxic T-lymphocytes. Augmentation of T-cell activation by positive co-stimulation and Major Histocompatibility Complex-restricted presentation of the culprit drug triggers T-cell activation following interaction with T-cell receptors. This T-cell activation results in expression of cytokines including TNF-α, interferon-γ, granzyme B and granulysin from NK cells. Besides their role in causing SJS/TEN, these cytokines cause coagulation activation. Materials & Methods Following an Institutional Review Board approved protocol blood samples were obtained from subjects suspected of SJS/TEN and normal healthy volunteers (n=2). Confirmatory biopsies were performed in all SJS/TEN subjects which confirmed SJS/TEN in 4 subjects and were negative in 7 subjects. Cytokine levels were measured using the cerebral II array biochip from Randox Laboratories Limited (Crumlin, UK). Besides cerebral array II, other parameters such as thrombin-antithrombin (TAT) complexes (Dade®, Marburg, Germany), fibrinopeptide A (F1.2, Dade®), plasminogen activator inhibitor-1 (PAI-1, Diagnostica Stago® and STACHROME antithrombin (Stago®), ZYMUPHEN platelet microparticles activity (Hyphen® Biomed (Neuville-sur-Oise, France), and HEMOCLOT protein C (Stago®) were measured using ELISA kits as per manufacturers’ instructions. Results Compared to the Normal Human Plasma, the IL-4, IL-6, TNF-α, and MCP-1 levels were increased significantly in biopsy-confirmed SJS/TEN patients (see table). Other parameters measured including IL-2, IL-8, IL-10, VEGF, INF-γ, IL-1α, IL1-β and EGF were not significantly increased. A marked increase in the TAT complexes (6.3±5.9 µg/ml), F1.2 (430.4±202.4 pmol/L), platelet microparticles (13.1±9.3 nM) and protein C levels (90.5±63.4%) with a corresponding decrease in PAI-1 (53.3±18.8ng/ml) and antithrombin levels (80.7±42.4%) compared to normal human plasma were also observed. Biopsy-negative SJS/TEN subjects with less pronounced inflammatory stimulus, demonstrated mild elevation in cytokine levels of IL-4 (1.95±0.59 pg/ml), IL-6 (29.81±25.18 pg/ml), TNF-α (7.20±5.04 pg/ml) and MCP-1 (265.10±159.09 pg/ml)). Conclusions T-cell activation and release of cytokines especially TNF-α and granzyme B causes immune-mediated activation of coagulation with increase in TAT, MCP-1, F1.2 and platelet microparticles and corresponding decrease of protein C, antithrombin, and PAI-1. These alterations in coagulation may progress to sepsis associated coagulopathy and overt disseminated intravascular coagulation. Disclosures: No relevant conflicts of interest to declare.

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Singla, Pooja, Priyadarshini Sahu, Pratibha Mane, and Prakriti Vohra. "Mixed dermatophytic infections: a learning perspective and report of ten cases." International Journal of Advances in Medicine 6, no. 1 (January 23, 2019): 174. http://dx.doi.org/10.18203/2349-3933.ijam20190126.

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Background: Isolation of two or more than two pathogenic fungi from the same body site in a patient is considered as a rare entity and very few cases have been reported in literature. These types of infections are called as mixed/ combined fungal infections. Author are enumerating ten cases of superficial mycoses in which two different dermatophytes were grown from the same focus.Methods: From clinically suspected cases of dermatophytosis, skin and hair samples were collected from the affected sites and examined by standard mycological procedures. Microscopy was done by using 10% KOH wet mount. Culture was put on Sabouraud’s dextrose agar with cyclohexamide medium. Growth was identified by lactophenol cotton blue mount.Results: Mixed dermatophytes were obtained from tinea corporis (five cases), tinea capitis (four cases) and tinea cruris (one case) patients. Fungal combinations from given cases involved two different species of genus Trichophyton which were as follows: T. violaceum+T. tonsurans, T. verrucosum+T. tonsurans, T. violaceum (violet) and T. violaceum (white), T. mentagrophytes+T. Violaceum, T. rubrum+T. tonsurans, T. violaceum+T. rubrum, T. rubrum+T. mentagrophytes, T. verrucosum+T. mentagrophytes, T. mentagrophytes+T. tonsurans, Malassezia+T. mentagrophytes.Conclusions: Inspite of the frequent occurrence of dermatophytic infections worldwide, reports on mixed dermatophytes are very few. With proper sample collection and proper identification procedures, more cases can be identified and added to the existing literature.

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Yang, Wei, Xiaofeng Xu, Dajing Xia, Huaichong Wang, Jing Jiang, and Guoliang Yang. "Toxic epidermal necrolysis associated with chemoimmunotherapy for lymphoma: case report and literature review." Immunotherapy 14, no. 5 (April 2022): 275–82. http://dx.doi.org/10.2217/imt-2021-0074.

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Aim: The emergence of antitumor immunotherapy has been beneficial for patients with tumors, but more attention should be paid to the toxic side effects of chemoimmunotherapy. Here we describe a patient with NK/T-cell lymphoma who developed toxic epidermal necrolysis (TEN) during treatment with a regimen consisting of sintilimab combined with pegaspargase, gemcitabine and oxaliplatin (P-GemOx). Case presentation: A patient received six cycles of P-GemOx chemotherapy as first-line treatment; 1 year later, he received the same dose of P-GemOx combined with sintilimab as chemoimmunotherapy due to recurrence of NK/T-cell lymphoma. He developed a massive rash that quickly developed into TEN after the fourth chemoimmunotherapy. Conclusion: Although rare, cases of fatal TEN caused by single-agent PD-1 inhibitor or gemcitabine have been reported. Careful attention to drug-related cutaneous toxicities is needed when these two agents are combined. This report highlights the significance of TEN as a rapid and serious adverse event induced by chemoimmunotherapy.

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Hakamada, Taku, Kiyomi Funatsuki, Hiroki Morita, Takuhiro Ugajin, Ikuo Nakamura, Hiroaki Ishiko, Yasushi Matsuzaki, Naomi Tanaka, and Michio Imawari. "Identification of novel hepatitis C virus-specific cytotoxic T lymphocyte epitopes by ELISpot assay using peptides with human leukocyte antigen-A*2402-binding motifs." Journal of General Virology 85, no. 6 (June 1, 2004): 1521–31. http://dx.doi.org/10.1099/vir.0.79801-0.

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The human leukocyte antigen (HLA)-A*2402 is common in Asians. The authors attempted to identify epitopes for HLA-A*2402-restricted, hepatitis C virus (HCV)-specific CD8+ T cells by an enzyme-linked immunospot (ELISpot) assay using peripheral blood CD8+ T cells from HLA-A*2402-positive hepatitis C patients and synthetic HCV peptides based on HLA-A*2402-binding motifs and the amino acid sequence of type 1b HCV. Ten novel epitopes were identified in five of seven HLA-A*2402-positive patients with acute or short-term chronic HCV infection (<3 years), but in none of four with longer-term chronic infection (>10 years). Only one of the ten epitopes proved to be definitely HLA-A*2402-restricted. Another epitope was identified in one of two HLA-A*2402-negative acute hepatitis C patients. In two of the six patients with positive CD8+ T cell responses, the targeted epitopes were multiple. The same epitope was targeted in two patients. When patients with unresolved acute HCV infection were treated with alpha interferon, peripheral blood HCV-specific CD8+ T cells decreased with resolution of the hepatitis. In conclusion, CD8+ T cell responses to HCV infection are heterogeneous. One definite HLA-A*2402-restricted and ten probably non-HLA-A*2402-restricted epitopes were identified. Patients with short-term HCV infection are suitable for searching for novel HCV epitopes, but peripheral blood HCV-specific CD8+ T cells decrease markedly after loss of antigenic stimulation.

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Miyazaki, Kazuko, Hitomi Watanabe, Genki Yoshikawa, Kenian Chen, Reiko Hidaka, Yuki Aitani, Kai Osawa, et al. "The transcription factor E2A activates multiple enhancers that drive Rag expression in developing T and B cells." Science Immunology 5, no. 51 (September 4, 2020): eabb1455. http://dx.doi.org/10.1126/sciimmunol.abb1455.

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Cell type–specific gene expression is driven by the interplay between lineage-specific transcription factors and cis-regulatory elements to which they bind. Adaptive immunity relies on RAG-mediated assembly of T cell receptor (TCR) and immunoglobulin (Ig) genes. Although Rag1 and Rag2 expression is largely restricted to adaptive lymphoid lineage cells, it remains unclear how Rag gene expression is regulated in a cell lineage–specific manner. Here, we identified three distinct cis-regulatory elements, a T cell lineage–specific enhancer (R-TEn) and the two B cell–specific elements, R1B and R2B. By generating mice lacking either R-TEn or R1B and R2B, we demonstrate that these distinct sets of regulatory elements drive the expression of Rag genes in developing T and B cells. What these elements have in common is their ability to bind the transcription factor E2A. By generating a mouse strain that carries a mutation within the E2A binding site of R-TEn, we demonstrate that recruitment of E2A to this site is essential for orchestrating changes in chromatin conformation that drive expression of Rag genes in T cells. By mapping cis-regulatory elements and generating multiple mouse strains lacking distinct enhancer elements, we demonstrate expression of Rag genes in developing T and B cells to be driven by distinct sets of E2A-dependent cis-regulatory modules.

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Matsumoto, Yosuke, Shigeo Horiike, Muneo Ohshiro, Mio Yamamoto, Nana Sasaki, Yasuhiko Tsutsumi, Tsutomu Kobayashi, et al. "Expression of Master Regulators of Helper T-Cell Differentiation in Peripheral T-Cell Lymphoma, Not Otherwise Specified by Immunohistochemical Analysis." Blood 114, no. 22 (November 20, 2009): 5004. http://dx.doi.org/10.1182/blood.v114.22.5004.5004.

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Abstract Abstract 5004 Background Peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS) comprises nodal and extranodal mature T-cell lymphomas, which do not correspond to any of the specifically defined entities of mature T-cell lymphoma in the current classification. During T-cell maturation, naïve T-cells include two distinct cell types, CD4-positive helper T-cells (Th) and CD8-positive cytotoxic T-cells. Following antigen stimulation, naïve Th cells differentiate into several subtypes of effector Th cells, including helper T-cells type1 (Th1), helper T-cells type 2 (Th2), follicular helper T-cells (TFH), regulatory T-cells (Treg), IL-17 producing T-cells (Th17), central memory T-cells (TCM), and effector memory T-cells (TEM). Previously, these subtypes of effector Th cells have been classified according to their pattern of cytokine secretion and expression of surface antigens, including chemokine receptors. More recent immunological researches have identified several transcription factors responsible for T-cell differentiation. The master regulators associated with Th, Th1, Th2, Th17, and Treg differentiation are reported to be Th-POK, T-Bet, GATA3, RORγt, and FOXP3, respectively. The origin of the neoplastic cells of PTCL-NOS is thought to be effector Th cells because the tumor cells usually express specific surface antigens such as pan-T-cell markers (CD2 and CD3), an effector T-cell marker (CD45RO), and a Th marker (CD4). However, the normal cellular derivation of PTCL-NOS remains unclear because the immunophenotypic profiles of PTCL-NOS are heterogeneous and not entirely disease specific. To presume the normal counterparts of PTCL-NOS, we used immunohistochemical analysis to examine the expression of the master regulators of T-cell differentiation and surface antigens, including chemokine receptors associated with the subtypes of Th cells. Patients and Methods The study population included ten Japanese patients who were diagnosed histopathologically with PTCL-NOS at the hospital of Kyoto Prefectural University of Medicine from 1993 to 2008. There were six male and four female patients who ranged in age from 26 to 78 years (mean 56 years) at diagnosis. Immunohistochemical staining was applied to 4-μm-thick paraffin-embedded sections of diagnostic lymph node, skin or liver tumor biopsy specimens. Sections were stained using a standard indirect avidin-biotin horseradish peroxidase method and diaminobenzidine (DAB) color development. Cases were considered positive if 25% or more of the tumor cells were stained with an antibody. For negative and positive staining controls, we used paraffin-embedded tissue sections of tonsillitis, nonspecific lymphadenitis, AILT, follicular lymphoma and diffuse large B-cell lymphoma. Results First, we examined the expression of the master regulator of helper T-cells (Th-POK) and the marker of effector T-cells (CD45RO), and all cases were positive for both. Next, we examined the expression of the master regulators of differentiation to subpopulations within Th cells (Th1, Th2, Treg and Th17). Three cases each were positive for T-Bet, and GATA3, but none of the cases showed FOXP3 or RORγt. Among the four cases not expressing these master regulators, two cases were positive for the surface antigens of central memory (TCM) (CCR7 and CD62L), and one case was positive for follicular helper T-cell (TFH) phenotype (BCL6, CXCL13 and PD-1). The remaining case was negative for all markers of effector Th subtypes. Conclusions All ten PTCL-NOS cases exhibited CD45RO and Th-POK, which characterized effector helper T-cells. Furthermore, the lymphoma cells of nine of the ten cases exhibited the expression of master regulators or surface antigens which characterized Th1, Th2, TCM and TFH. Disclosures No relevant conflicts of interest to declare.

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Kyhn, Line A., Jakob Tougaard, Jonas Teilmann, Magnus Wahlberg, Poul B. Jørgensen, and Nikolaj I. Bech. "Harbour porpoise (Phocoena phocoena) static acoustic monitoring: laboratory detection thresholds of T-PODs are reflected in field sensitivity." Journal of the Marine Biological Association of the United Kingdom 88, no. 6 (March 17, 2008): 1085–91. http://dx.doi.org/10.1017/s0025315408000416.

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The T-POD (Timing POrpoise Detector) is a self-contained acoustic data logger used for detecting and monitoring the presence of echolocation clicks of small cetaceans. It has become a standard tool in environmental impact assessments and monitoring programmes. Yet, little is known about the variability in sensitivity and detection range of T-PODs. In this study the field performance of ten v3 T-PODs was compared to detection thresholds measured in a tank. The T-POD thresholds ranged from 123 to 132 dB re 1μPa (pp). The detection thresholds of the ten individual T-PODs were different and the differences increased over time. The more sensitive a T-POD was in the laboratory (i.e. the lower the threshold) the more clicks were recorded by it in the field. Threshold correlated differently to the five analysed T-POD parameters (encounters, encounter duration, waiting time, porpoise positive minutes, clicks per porpoise positive minute). This study demonstrates that individual threshold calibrations of T-PODs are necessary to obtain comparable results when monitoring odontocetes with this tool. Regression equations for relationships between T-POD detection thresholds and study parameters obtained during field trials may allow comparisons of T-PODs with different detection thresholds.

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Heich, Hermann-Josef, Jutta Jantunen, and Emanuele Negrenti. "The assessment of environmental and safety impacts of the trans-European transport network (TEN-T)." Science of The Total Environment 235, no. 1-3 (September 1999): 391–93. http://dx.doi.org/10.1016/s0048-9697(99)00243-0.

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Otsuka, Noriko, Tiziana Delmastro, Dirk Wittowsky, Stefano Pensa, and Marlene Damerau. "Assessing the accessibility of urban nodes: the case of TEN-T railway stations in Europe." Applied Mobilities 4, no. 2 (February 26, 2019): 219–43. http://dx.doi.org/10.1080/23800127.2019.1573778.

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Zhang, Keke, Huan Shen, Shijie Xu, Huihui Zhang, Minghe Zhu, Peng Shi, Xiaoyan Fu, Yaoyao Yang, and Junbo Gong. "Thermodynamic study of solubility for pyrazinamide in ten solvents from T = (283.15 to 323.15) K." Journal of Chemical Thermodynamics 112 (September 2017): 204–12. http://dx.doi.org/10.1016/j.jct.2017.04.014.

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Journal articles on the topic 'Ten-t'

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