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1

Cover, Giovana, Mariana Pereira, Mariana Bento, Simone Appenzeller, and Leticia Rittner. "Data-Driven Corpus Callosum Parcellation Method Through Diffusion Tensor Imaging." IEEE Access 5 (2017): 22421–32. http://dx.doi.org/10.1109/access.2017.2761701.

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Kallehauge, Jesper Foldsted, Trine Lignell Guldberg, Anja Harbøll, Morten Bjørn Jensen, and Slávka Lukacova. "RTHP-09. DIFFUSION TENSOR IMAGING DRIVEN GROWTH MODELING FOR TARGET DEFINITION IN GLIOBLASTOMA." Neuro-Oncology 19, suppl_6 (2017): vi221. http://dx.doi.org/10.1093/neuonc/nox168.894.

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Jensen, Morten B., Trine L. Guldberg, Anja Harbøll, Slávka Lukacova, and Jesper F. Kallehauge. "Diffusion tensor magnetic resonance imaging driven growth modeling for radiotherapy target definition in glioblastoma." Acta Oncologica 56, no. 11 (2017): 1639–43. http://dx.doi.org/10.1080/0284186x.2017.1374559.

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4

Drblíková, Olga, Angela Handlovičová, and Karol Mikula. "Error estimates of the finite volume scheme for the nonlinear tensor-driven anisotropic diffusion." Applied Numerical Mathematics 59, no. 10 (2009): 2548–70. http://dx.doi.org/10.1016/j.apnum.2009.05.010.

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Jia, Xiao-xiong, Yang Yu, Xiao-dong Wang, et al. "fMRI-Driven DTT Assessment of Corticospinal Tracts Prior to Cortex Resection." Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 40, no. 4 (2013): 558–63. http://dx.doi.org/10.1017/s0317167100014669.

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Abstract:Background:The role of diffusion tensor tractography (DTT) has become increasingly important in the preoperative mapping of brain white matter. Recently, functional magnetic resonance imaging (fMRI) driven DTT has provided the ability to evaluate the spatial relationship between the corticospinal tract (CST) and motor resection tumor boundaries. The main objective of this study was improvement of the preoperative assessment of the CST in patients with gliomas involving the motor cortical areas.Methods:Seventeen patients with gliomas involving motor cortical areas underwent 3 dimension
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Kim, Jeongchul, Youngkyoo Jung, Richard Barcus, et al. "Rhesus Macaque Brain Developmental Trajectory: A Longitudinal Analysis Using Tensor-Based Structural Morphometry and Diffusion Tensor Imaging." Cerebral Cortex 30, no. 8 (2020): 4325–35. http://dx.doi.org/10.1093/cercor/bhaa015.

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Abstract The typical developmental trajectory of brain structure among nonhuman primates (NHPs) remains poorly understood. In this study, we characterized the normative trajectory of developmental change among a cohort of rhesus monkeys (n = 28), ranging in age from 2 to 22 months, using structural MRI datasets that were longitudinally acquired every 3–4 months. We hypothesized that NHP-specific transient intracranial volume decreases reported during late infancy would be part of the typical developmental process, which is driven by volumetric contraction of gray matter in primary functional a
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Engelbrecht, N. Eugene. "On the Effects of Pickup Ion-driven Waves on the Diffusion Tensor of Low-energy Electrons in the Heliosphere." Astrophysical Journal 849, no. 1 (2017): L15. http://dx.doi.org/10.3847/2041-8213/aa9372.

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8

Hoh, N. J., and R. N. Zia. "Force-induced diffusion in suspensions of hydrodynamically interacting colloids." Journal of Fluid Mechanics 795 (April 20, 2016): 739–83. http://dx.doi.org/10.1017/jfm.2016.209.

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We study the influence of hydrodynamic, thermodynamic and interparticle forces on the diffusive motion of a Brownian probe driven by a constant external force through a dilute colloidal dispersion. The influence of these microscopic forces on equilibrium self-diffusivity (passive microrheology) is well known: all three act to hinder the short- and long-time self-diffusion. Here, via pair-Smoluchowski theory, we explore their influence on self-diffusion in a flowing suspension, where particles and fluid have been set into motion by an externally forced probe (active microrheology), giving rise
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Koch, Donald L., and John F. Brady. "Dispersion in fixed beds." Journal of Fluid Mechanics 154 (May 1985): 399–427. http://dx.doi.org/10.1017/s0022112085001598.

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A macroscopic equation of mass conservation is obtained by ensemble-averaging the basic conservation laws in a porous medium. In the long-time limit this ‘macro-transport’ equation takes the form of a macroscopic Fick's law with a constant effective diffusivity tensor. An asymptotic analysis in low volume fraction of the effective diffusivity in a bed of fixed spheres is carried out for all values of the Péclet number ℙ = Ua/Df, where U is the average velocity through the bed. a is the particle radius and Df is the molecular diffusivity of the solute in the fluid. Several physical mechanisms c
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10

Emsell, L., C. Chaddock, N. Forde, et al. "White matter microstructural abnormalities in families multiply affected with bipolar I disorder: a diffusion tensor tractography study." Psychological Medicine 44, no. 10 (2013): 2139–50. http://dx.doi.org/10.1017/s0033291713002845.

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BackgroundWhite matter (WM) abnormalities are proposed as potential endophenotypic markers of bipolar disorder (BD). In a diffusion tensor imaging (DTI) voxel-based analysis (VBA) study of families multiply affected with BD, we previously reported that widespread abnormalities of fractional anisotropy (FA) are associated with both BD and genetic liability for illness. In the present study, we further investigated the endophenotypic potential of WM abnormalities by applying DTI tractography to specifically investigate tracts implicated in the pathophysiology of BD.MethodDiffusion magnetic reson
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11

Richard, Geneviève, Knut Kolskår, Anne-Marthe Sanders, et al. "Assessing distinct patterns of cognitive aging using tissue-specific brain age prediction based on diffusion tensor imaging and brain morphometry." PeerJ 6 (November 30, 2018): e5908. http://dx.doi.org/10.7717/peerj.5908.

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Multimodal imaging enables sensitive measures of the architecture and integrity of the human brain, but the high-dimensional nature of advanced brain imaging features poses inherent challenges for the analyses and interpretations. Multivariate age prediction reduces the dimensionality to one biologically informative summary measure with potential for assessing deviations from normal lifespan trajectories. A number of studies documented remarkably accurate age prediction, but the differential age trajectories and the cognitive sensitivity of distinct brain tissue classes have yet to be adequate
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12

de Andrade, L. C. Garcia. "General relativistic magnetic perturbations and dynamo effects in extragalactic radiosources." Proceedings of the International Astronomical Union 6, S274 (2010): 393–97. http://dx.doi.org/10.1017/s1743921311007356.

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AbstractBy making use of the MHD self-induction equation in general relativity (GR), recently derived by Clarkson and Marklund (2005), it is shown that when Friedmann universe possesses a spatial section whose Riemannian curvature is negative, the magnetic energy bounds computed by Nuñez (2002) also bounds the growth rate of the magnetic field given by the strain matrix of dynamo flow. Since in GR-MHD dynamo equation, the Ricci tensor couples with the universe magnetic field, only through diffusion, and most ages are highly conductive the interest is more theoretical here, and only very specif
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13

Nigro, Salvatore, Luca Passamonti, Roberta Riccelli, et al. "Structural ‘connectomic’ alterations in the limbic system of multiple sclerosis patients with major depression." Multiple Sclerosis Journal 21, no. 8 (2014): 1003–12. http://dx.doi.org/10.1177/1352458514558474.

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Background: Major depression (MD) is a common psychiatric disorder in multiple sclerosis (MS). Despite the negative impact of MD on the quality of life of MS patients, little is known about its underlying brain mechanisms. Objective: We studied the whole-brain connectivity patterns that were associated with MD in MS. Alterations were mainly expected within limbic circuits. Methods: Diffusion tensor imaging data were collected in 20 MS patients with MD, 22 non-depressed MS patients and 16 healthy controls. We used deterministic tractography and graph analysis to study the white-matter connectiv
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14

Tam, Lydia T., Nathan N. Ng, Emily S. McKenna, Lisa Bruckert, Kristen W. Yeom, and Cynthia J. Campen. "Effects of Age on White Matter Microstructure in Children With Neurofibromatosis Type 1." Journal of Child Neurology 36, no. 10 (2021): 894–900. http://dx.doi.org/10.1177/08830738211008736.

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Children with neurofibromatosis type 1 (NF1) often report cognitive challenges, though the etiology of such remains an area of active investigation. With the advent of treatments that may affect white matter microstructure, understanding the effects of age on white matter aberrancies in NF1 becomes crucial in determining the timing of such therapeutic interventions. A cross-sectional study was performed with diffusion tensor imaging from 18 NF1 children and 26 age-matched controls. Fractional anisotropy was determined by region of interest analyses for both groups over the corpus callosum, cin
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15

Breeden, A. L., E. M. Cardinale, L. M. Lozier, J. W. VanMeter, and A. A. Marsh. "Callous-unemotional traits drive reduced white-matter integrity in youths with conduct problems." Psychological Medicine 45, no. 14 (2015): 3033–46. http://dx.doi.org/10.1017/s0033291715000987.

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Background.Callous-unemotional (CU) traits represent a significant risk factor for severe and persistent conduct problems in children and adolescents. Extensive neuroimaging research links CU traits to structural and functional abnormalities in the amygdala and ventromedial prefrontal cortex. In addition, adults with psychopathy (a disorder for which CU traits are a developmental precursor) exhibit reduced integrity in uncinate fasciculus, a white-matter (WM) tract that connects prefrontal and temporal regions. However, research in adolescents has not yet yielded similarly consistent findings.
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Ameis, Stephanie H., Jin Fan, Conrad Rockel, Latha Soorya, A. Ting Wang, and Evdokia Anagnostou. "Altered cingulum bundle microstructure in autism spectrum disorder." Acta Neuropsychiatrica 25, no. 5 (2013): 275–82. http://dx.doi.org/10.1017/neu.2013.2.

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ObjectiveHere, we examined the cingulum bundle, a long-range white matter tract mediating dorsal limbic connectivity, using diffusion tensor imaging (DTI) tractography, in children and adolescents with autism spectrum disorder (ASD) versus controls. We hypothesised that cingulum bundle microstructure would be altered in ASD, based on evidence implicating abnormal white matter connectivity in this disorder.MethodsDTI data were acquired for 19 ASD participants (IQ ⩾ 70; 7–18 years; mean = 12.4 ± 3.1) and 16 age-matched controls (7–18 years; mean = 12.3 ± 3.6) on a 3 T magnetic resonance imaging
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17

Kaczmarz, Stephan, Jens Göttler, Claus Zimmer, Fahmeed Hyder, and Christine Preibisch. "Characterizing white matter fiber orientation effects on multi-parametric quantitative BOLD assessment of oxygen extraction fraction." Journal of Cerebral Blood Flow & Metabolism 40, no. 4 (2019): 760–74. http://dx.doi.org/10.1177/0271678x19839502.

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Relative oxygen extraction fraction (rOEF) is a fundamental indicator of cerebral metabolic function. An easily applicable method for magnetic resonance imaging (MRI) based rOEF mapping is the multi-parametric quantitative blood oxygenation level dependent (mq-BOLD) approach with separate acquisitions of transverse relaxation times [Formula: see text] and T2 and dynamic susceptibility contrast (DSC) based relative cerebral blood volume (rCBV). Given that transverse relaxation and rCBV in white matter (WM) strongly depend on nerve fiber orientation, mq-BOLD derived rOEF is expected to be affect
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18

Dharmadasa, Thanuja, Neil G. Simon, Chenyu Wang, Steve Vucic, and Matthew C. Kiernan. "021 Clinical implications of cortical dysfunction in motor neuron disease: a combined structural and functional approach." Journal of Neurology, Neurosurgery & Psychiatry 89, no. 6 (2018): A9.3—A10. http://dx.doi.org/10.1136/jnnp-2018-anzan.21.

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IntroductionMotor neuron disease (MND) is characterised by progressive failure of upper (UMN) and lower motor neurons (LMN). UMN dysfunction remains difficult to detect clinically, and the influence of cortical change on disease progression and prognosis remains unclarified. This study quantitatively assessed cortical dysfunction in vivo using a novel combined structural and functional approach.MethodsForty-one newly diagnosed MND patients and 30 controls prospectively underwent 3T diffusion tensor magnetic resonance imaging (DTI) to assess cerebral white matter structural integrity. DTI measu
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19

ROBERT, ASHISH, T. VAITHIANATHAN, LANCE R. COLLINS, and JAMES G. BRASSEUR. "Polymer-laden homogeneous shear-driven turbulent flow: a model for polymer drag reduction." Journal of Fluid Mechanics 657 (June 28, 2010): 189–226. http://dx.doi.org/10.1017/s0022112010001394.

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Drag reduction (DR) under a turbulent boundary layer implies the suppression of turbulent momentum flux to the wall, a large-eddy phenomenon. Our hypothesis is that the essential mechanisms by which dilute concentrations of long-chain polymer molecules reduce momentum flux involve only the interactions among turbulent velocity fluctuations, polymer molecules and mean shear. Experiments indicate that these interactions dominate in a polymer-active ‘elastic layer’ outside the viscous sublayer and below a Newtonian inertial layer in a polymer-laden turbulent boundary layer. We investigate our hyp
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Michels, Lars, Foteini Christidi, Vivian R. Steiger, et al. "Pain modulation is affected differently in medication-overuse headache and chronic myofascial pain – A multimodal MRI study." Cephalalgia 37, no. 8 (2016): 764–79. http://dx.doi.org/10.1177/0333102416652625.

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Background Neuroimaging studies revealed structural and functional changes in medication-overuse headache (MOH), but it remains unclear whether similar changes could be observed in other chronic pain disorders. Methods In this cross-sectional study, we investigated functional connectivity (FC) with resting-state functional magnetic resonance imaging (fMRI) and white matter integrity using diffusion tensor imaging (DTI) to measure fractional anisotropy (FA) and mean diffusivity (MD) in patients with MOH ( N = 12) relative to two control groups: patients with chronic myofascial pain (MYO; N = 11
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Chen, Rong, Kyunghun Lee, and Edward H. Herskovits. "Computational framework for detection of subtypes of neuropsychiatric disorders based on DTI-derived anatomical connectivity." Neuroradiology Journal 33, no. 5 (2020): 393–99. http://dx.doi.org/10.1177/1971400920950694.

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Many brain disorders – such as Alzheimer’s disease, Parkinson’s disease, schizophrenia and autism – are heterogeneous, that is, they may have several subtypes. Traditionally, clinicians have identified subtypes, such as subtypes of psychosis, using clinical criteria. Neuroimaging has the potential to detect subtypes based on objective biomarker-based criteria; however, there are no studies that evaluate the application of combining unsupervised machine learning and anatomical connectivity analysis to accomplish this goal. We propose a computational framework to detect subtypes based on anatomi
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Samani, Zahra Riahi, Drew Parker, Jacob Antony Alappatt, Steven Brem, and Ragini Verma. "NIMG-45. DEEP LEARNING-BASED PERITUMORAL MICROSTRUCTURE MAPPING IN GLIOBLASTOMAS USING FREE WATER VOLUME FRACTION." Neuro-Oncology 22, Supplement_2 (2020): ii157—ii158. http://dx.doi.org/10.1093/neuonc/noaa215.658.

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Abstract PURPOSE Characterization of the peritumoral microenvironment is a widely researched, but as yet unsolved problem. Determining the tissue microstructure differences between tumor types, arising from differences in infiltration, edema, and disease driven changes in cellularity is important to be able to guide treatment options. Diffusion tensor imaging with characterization of extracellular free water provides unique information of the tissue microstructure. The goal of this work is to leverage this information by applying deep learning on free water maps and create a microstructure map
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Sizonenko, Stéphane V., Claudio Babiloni, Eveline A. de Bruin, et al. "Brain imaging and human nutrition: which measures to use in intervention studies?" British Journal of Nutrition 110, S1 (2013): S1—S30. http://dx.doi.org/10.1017/s0007114513001384.

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The present review describes brain imaging technologies that can be used to assess the effects of nutritional interventions in human subjects. Specifically, we summarise the biological relevance of their outcome measures, practical use and feasibility, and recommended use in short- and long-term nutritional studies. The brain imaging technologies described consist of MRI, including diffusion tensor imaging, magnetic resonance spectroscopy and functional MRI, as well as electroencephalography/magnetoencephalography, near-IR spectroscopy, positron emission tomography and single-photon emission c
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Khalique, Zohya, and Dudley Pennell. "Diffusion tensor cardiovascular magnetic resonance." Postgraduate Medical Journal 95, no. 1126 (2019): 433–38. http://dx.doi.org/10.1136/postgradmedj-2019-136429.

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Cardiac structure and function are complex and inter-related. Current in vivo techniques assess the heart on a macroscopic scale, but a novel technique called diffusion tensor cardiovascular magnetic resonance (DT-CMR) can now assess the cardiac microstructure non-invasively. It provides information on the helical arrangement of cardiomyocytes that drives torsion and offers dynamic assessment of the sheetlets (aggregated cardiomyocytes) that rotate through the cardiac cycle to facilitate wall thickening. Through diffusion biomarkers, the expansion and organisation of the underlying myocardium
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Hallez, Yannick, and Jacques Magnaudet. "Buoyancy-induced turbulence in a tilted pipe." Journal of Fluid Mechanics 762 (December 8, 2014): 435–77. http://dx.doi.org/10.1017/jfm.2014.638.

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AbstractNumerical simulation is used to document the statistical structure and better understand energy transfers in a low-Reynolds-number turbulent flow generated by negative axial buoyancy in a long circular tilted pipe under the Boussinesq approximation. The flow is found to exhibit specific features which strikingly contrast with the familiar characteristics of pressure-driven pipe and channel flows. The mean flow, dominated by an axial component exhibiting a uniform shear in the core, also comprises a weak secondary component made of four counter-rotating cells filling the entire cross-se
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Manigos, Kirby, Kevin Paul Ferraris, Joseph Erroll Navarro, Kenny Seng, and Jose Carlos Alcazaren. "SURG-08. AWAKE CRANIOTOMY WITH BRAIN MAPPING FOR DIFFUSE LOW-GRADE GLIOMA: CASE REPORT OF INSTITUTIONAL EXPERIENCE IN OVERCOMING HURDLES IN A LOW-RESOURCE SETTING." Neuro-Oncology 22, Supplement_2 (2020): ii204—ii205. http://dx.doi.org/10.1093/neuonc/noaa215.855.

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Abstract Maximal safe resection of low-grade gliomas located in functional areas of the cortex while avoiding postsurgical neurologic deficits can be achieved by awake craniotomy with brain mapping. The effectiveness of this surgical technique is fairly established in the developed world, however it remains to be routinely applied in low-middle income countries due to limited resources and lack of equipment. We present the case of a 44 year-old, right-handed male who had a 2-year history of focal aware motor seizures but was otherwise neurologically intact. Neuropsychological testing revealed
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CAMPBELL, CHARLES S. "Self-diffusion in granular shear flows." Journal of Fluid Mechanics 348 (October 10, 1997): 85–101. http://dx.doi.org/10.1017/s0022112097006496.

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The collisionally induced random particle velocities in a rapid granular shear flow drive the diffusion of particles in manner directly analogous to the thermal diffusion of molecules or the eddy-induced diffusion in a turbulent flow. This paper reports measurements, via computer simulation, of the anisotropic diffusion tensor for a granular shear flow. The components are determined both by particle tracking and through velocity correlations, which are found to agree with reasonable accuracy. As might be expected from symmetry arguments, there are four non-zero components generated in a simple
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Bandyopadhyay, Abhijit, and Anirban Chatterjee. "Realizing interactions between dark matter and dark energy using k-essence cosmology." Modern Physics Letters A 34, no. 27 (2019): 1950219. http://dx.doi.org/10.1142/s0217732319502195.

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In this paper, we exploit dynamics of a [Formula: see text]-essence scalar field to realize interactions between dark components of universe resulting in an evolution consistent with observed features of late-time phase of cosmic evolution. Stress–energy tensor corresponding to a [Formula: see text]-essence Lagrangian [Formula: see text] (where [Formula: see text]) is shown to be equivalent to an ideal fluid with two components having same equation of state. Stress–energy tensor of one of the components may be generated from a constant potential [Formula: see text]-essence Lagrangian of form [
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29

Holden, Arun V. "Defibrillation in Models of Cardiac Muscle." Journal of Theoretical Medicine 1, no. 2 (1997): 91–102. http://dx.doi.org/10.1080/10273669708833010.

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The propagation of electrical activity in cardiac tissue can be modelled by reaction diffusion equations, where a tensor of diffusion coefficients represents anisotropy due to fiber orintation, and excitation is represented by high-order, stiff differential systems. The effects of external electrical stimulation, as in artifical pacemakers, or in defibrillators, requires bidomain models, in wich intra- and extracellular currents are treated separately.simplified approaches are taken to this problem to illustrate two methods of defibrillation: by a sinhle large pulse, that eliminates all propag
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Meijer, Kim A., Martijn D. Steenwijk, Linda Douw, Menno M. Schoonheim, and Jeroen J. G. Geurts. "Long-range connections are more severely damaged and relevant for cognition in multiple sclerosis." Brain 143, no. 1 (2019): 150–60. http://dx.doi.org/10.1093/brain/awz355.

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Abstract An efficient network such as the human brain features a combination of global integration of information, driven by long-range connections, and local processing involving short-range connections. Whether these connections are equally damaged in multiple sclerosis is unknown, as is their relevance for cognitive impairment and brain function. Therefore, we cross-sectionally investigated the association between damage to short- and long-range connections with structural network efficiency, the functional connectome and cognition. From the Amsterdam multiple sclerosis cohort, 133 patients
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Park, Clara, Yiling Fan, Gregor Hager, et al. "An organosynthetic dynamic heart model with enhanced biomimicry guided by cardiac diffusion tensor imaging." Science Robotics 5, no. 38 (2020): eaay9106. http://dx.doi.org/10.1126/scirobotics.aay9106.

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The complex motion of the beating heart is accomplished by the spatial arrangement of contracting cardiomyocytes with varying orientation across the transmural layers, which is difficult to imitate in organic or synthetic models. High-fidelity testing of intracardiac devices requires anthropomorphic, dynamic cardiac models that represent this complex motion while maintaining the intricate anatomical structures inside the heart. In this work, we introduce a biorobotic hybrid heart that preserves organic intracardiac structures and mimics cardiac motion by replicating the cardiac myofiber archit
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Palmer, H. S., A. K. Håberg, M. S. Fimland, et al. "Structural brain changes after 4 wk of unilateral strength training of the lower limb." Journal of Applied Physiology 115, no. 2 (2013): 167–75. http://dx.doi.org/10.1152/japplphysiol.00277.2012.

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Strength training enhances muscular strength and neural drive, but the underlying neuronal mechanisms remain unclear. This study used magnetic resonance imaging (MRI) to identify possible changes in corticospinal tract (CST) microstructure, cortical activation, and subcortical structure volumes following unilateral strength training of the plantar flexors. Mechanisms underlying cross-education of strength in the untrained leg were also investigated. Young, healthy adult volunteers were assigned to training ( n = 12) or control ( n = 9) groups. The 4 wk of training consisted of 16 sessions of 3
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Boyd, Lara A., Eric D. Vidoni, and Janis J. Daly. "Answering the Call: The Influence of Neuroimaging and Electrophysiological Evidence on Rehabilitation." Physical Therapy 87, no. 6 (2007): 684–703. http://dx.doi.org/10.2522/ptj.20060164.

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Functional recovery after brain damage or disease is dependent on the neuroplastic capability of the cortex and the nonaffected brain. Following cortical injury in the motor and sensory regions, the adjacent spared neural tissues and related areas undergo modifications that are required in order to drive more normal motor control. Current rehabilitation models seek to stimulate functional recovery by capitalizing on the inherent potential of the brain for positive reorganization after neurological injury or disease. This article discusses how neuroimaging and electrophysiological data can info
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Zhou, Shi Wei, and Qing Li. "The Design of Functional Gradient Materials with Inverse Homogenization Method." Advanced Materials Research 32 (February 2008): 245–50. http://dx.doi.org/10.4028/www.scientific.net/amr.32.245.

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This study systemically presents an inverse homogenization method in the design of functional gradient materials, which gained substantial attention recently due to their layer-by-layer defined physical properties. Each layer of these materials is unilaterally constructed by periodically extended microstructural elements (namely base cells), whose effective properties can be decided by the homogenization theory in accordance with the material distribution within the base cell. The design objective is to minimize the summation of the least squares of the difference between corresponded entries
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Quezada, Sebastian, Yohan van de Looij, Nadia Hale, et al. "Genetic and microstructural differences in the cortical plate of gyri and sulci during gyrification in fetal sheep." Cerebral Cortex 30, no. 12 (2020): 6169–90. http://dx.doi.org/10.1093/cercor/bhaa171.

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Abstract Gyrification of the cerebral cortex is a developmentally important process, but the mechanisms that drive cortical folding are not fully known. Theories propose that changes within the cortical plate (CP) cause gyrification, yet differences between the CP below gyri and sulci have not been investigated. Here we report genetic and microstructural differences in the CP below gyri and sulci assessed before (at 70 days of gestational age [GA] 70), during (GA 90), and after (GA 110) gyrification in fetal sheep. The areal density of BDNF, CDK5, and NeuroD6 immunopositive cells were increase
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Hartwigsen, Gesa, Dorothee Saur, Cathy J. Price, Annette Baumgaertner, Stephan Ulmer, and Hartwig R. Siebner. "Increased Facilitatory Connectivity from the Pre-SMA to the Left Dorsal Premotor Cortex during Pseudoword Repetition." Journal of Cognitive Neuroscience 25, no. 4 (2013): 580–94. http://dx.doi.org/10.1162/jocn_a_00342.

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Previous studies have demonstrated that the repetition of pseudowords engages a network of premotor areas for articulatory planning and articulation. However, it remains unclear how these premotor areas interact and drive one another during speech production. We used fMRI with dynamic causal modeling to investigate effective connectivity between premotor areas during overt repetition of words and pseudowords presented in both the auditory and visual modalities. Regions involved in phonological aspects of language production were identified as those where regional increases in the BOLD signal w
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Mohanty, Sureswar, Srikant Kumar Swain, and Chinmay Biswal. "Brain Edema: Newer Concept of Treatment." Annals of the National Academy of Medical Sciences (India) 55, no. 04 (2019): 189–92. http://dx.doi.org/10.1055/s-0040-1701154.

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AbstractBrain edema is excess accumulation of water in intracellular or extracellular spaces of the brain. It may be due to traumatic brain injury, neoplasm, infection, or following surgery. Advent of electron microscope and molecular pathophysiology of fluid transport through blood–brain barrier has elucidated the mechanism of edema formation, that is, ion channels and transport of fluid into extracellular space. Currently approved treatments, such as decompressive craniectomy and osmotherapy, controlled hyperventilation, and administration of diuretics, were developed prior to any knowledge
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Xie, Di, Huan Liu, Fei Xu, et al. "IL33 (Interleukin 33)/ST2 (Interleukin 1 Receptor-Like 1) Axis Drives Protective Microglial Responses and Promotes White Matter Integrity After Stroke." Stroke 52, no. 6 (2021): 2150–61. http://dx.doi.org/10.1161/strokeaha.120.032444.

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Background and Purpose: Emerging evidence highlights the importance of IL33 (interleukin 33) and its receptor (ST2 [interleukin 1 receptor-like 1]) in normal brains and neurological disorders. This study explores the function of the IL33/ST2 signaling axis and a transcription factor STAT6 (signal transducer and activator of transcription 6) in white matter integrity and long-term recovery after stroke. Methods: Transient middle cerebral artery occlusion was induced in wild type, ST2 knockout, STAT6 knockout, and microglia/macrophage-depleted (by PLX5622 diet) mice. Sensorimotor and cognitive f
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Baig, Muhammad, Jason Johnson, Sumit Gupta, Zsila Sadighi, Wafik Zaky, and Soumen Khatua. "EPCT-06. A PHASE I STUDY OF MULTI-TARGETED THERAPY IN NEWLY DIAGNOSED OR PROGRESSIVE DIFFUSE INTRINSIC PONTINE GLIOMA." Neuro-Oncology 22, Supplement_3 (2020): iii304—iii305. http://dx.doi.org/10.1093/neuonc/noaa222.130.

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Abstract BACKGROUND Diffuse intrinsic pontine glioma (DIPG) constitutes 80% of pediatric brain stem tumors with a median survival of 12 months. The PI3K/AKT/mTOR pathway is a key oncogenic driver of this tumor. Targeting the chromatin dysregulation through HDAC inhibition, demonstrated benefit in vivo and vitro studies. We completed the first study as a multi-targeted therapy using SAHA and temsirolimus in pediatric DIPG. METHODS After receiving institutional IRB approval, we enrolled 6 patients on this phase I study using a 3 + 3 statistical design. Patients were divided into stratum 1 and st
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LEUNGA, CHARLES GUY NJIKE, and DONATIEN HAINAUT. "INTERBANK CREDIT RISK MODELING WITH SELF-EXCITING JUMP PROCESSES." International Journal of Theoretical and Applied Finance 23, no. 06 (2020): 2050039. http://dx.doi.org/10.1142/s0219024920500399.

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The credit crunch of 2007 caused major changes in the market of interbank rates making the existing interest rate theory inconsistent. This paper puts forward one way to reconcile practice and theory by modifying the arbitrage-free condition. In this framework, the forward Libor rate is no longer considered as a risk-free rate and the credit and liquidity risks within the interbank market partly drive its dynamics. In a similar manner to the multiple-curve approach, we model the evolution of default-free rates, assimilated to overnight interest swap rates, and the default times of an interbank
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Getreuer, Pascal. "Roussos-Maragos Tensor-Driven Diffusion for Image Interpolation." Image Processing On Line 1 (September 13, 2011). http://dx.doi.org/10.5201/ipol.2011.g_rmdi.

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Hong-mei, Zhang, Wan Ming-xi, and Bian Zheng-zhong. "Complementary tensor-driven image coherence diffusion for oriented structure enhancement." EURASIP Journal on Advances in Signal Processing 2011, no. 1 (2011). http://dx.doi.org/10.1186/1687-6180-2011-70.

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Sadeghi, Neda, Elizabeth Hutchinson, Carol Van Ryzin, et al. "Brain phenotyping in Moebius syndrome and other congenital facial weakness disorders by diffusion MRI morphometry." Brain Communications 2, no. 1 (2020). http://dx.doi.org/10.1093/braincomms/fcaa014.

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Abstract In this study, we used a novel imaging technique, DTI (diffusion tensor imaging)-driven tensor-based morphometry, to investigate brain anatomy in subjects diagnosed with Moebius syndrome (n = 21), other congenital facial weakness disorders (n = 9) and healthy controls (n = 15). First, we selected a subgroup of subjects who satisfied the minimum diagnostic criteria for Moebius syndrome with only mild additional neurological findings. Compared to controls, in this cohort, we found a small region of highly significant volumetric reduction in the paramedian pontine reticular formation and
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Lawrence, Katherine E., Leila Nabulsi, Vigneshwaran Santhalingam, et al. "Age and sex effects on advanced white matter microstructure measures in 15,628 older adults: A UK biobank study." Brain Imaging and Behavior, September 18, 2021. http://dx.doi.org/10.1007/s11682-021-00548-y.

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AbstractA comprehensive characterization of the brain’s white matter is critical for improving our understanding of healthy and diseased aging. Here we used diffusion-weighted magnetic resonance imaging (dMRI) to estimate age and sex effects on white matter microstructure in a cross-sectional sample of 15,628 adults aged 45–80 years old (47.6% male, 52.4% female). Microstructure was assessed using the following four models: a conventional single-shell model, diffusion tensor imaging (DTI); a more advanced single-shell model, the tensor distribution function (TDF); an advanced multi-shell model
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Hutchinson, Elizabeth B., Susan C. Schwerin, Kryslaine L. Radomski, et al. "Detection and Distinction of Mild Brain Injury Effects in a Ferret Model Using Diffusion Tensor MRI (DTI) and DTI-Driven Tensor-Based Morphometry (D-TBM)." Frontiers in Neuroscience 12 (August 17, 2018). http://dx.doi.org/10.3389/fnins.2018.00573.

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Orije, Jasmien, Emilie Cardon, Julie Hamaide, et al. "Uncovering a ‘sensitive window’ of multisensory and motor neuroplasticity in the cerebrum and cerebellum of male and female starlings." eLife 10 (June 7, 2021). http://dx.doi.org/10.7554/elife.66777.

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Traditionally, research unraveling seasonal neuroplasticity in songbirds has focused on the male song control system and testosterone. We longitudinally monitored the song behavior and neuroplasticity in male and female starlings during multiple photoperiods using Diffusion Tensor and Fixel-Based techniques. These exploratory data-driven whole-brain methods resulted in a population-based tractogram confirming microstructural sexual dimorphisms in the song control system. Furthermore, male brains showed hemispheric asymmetries in the pallium, whereas females had higher interhemispheric connecti
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Sharrack, N., A. Das, C. Kelly, et al. "The relationship between myocardial microstructure and strain in chronic infarcts, assessed using diffusion tensor imaging and feature tracking." European Heart Journal - Cardiovascular Imaging 22, Supplement_2 (2021). http://dx.doi.org/10.1093/ehjci/jeab090.073.

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Abstract Funding Acknowledgements Type of funding sources: Foundation. Main funding source(s): British Heart Foundation Background Cardiac diffusion tensor imaging (cDTI) is a novel technique for the non-invasive assessment of myocardial microstructure. It allows in-vivo characterisation of microstructural changes post myocardial infarction (MI). Previously published evidence shows significant loss of sheetlet orientation as derived by cDTI secondary eigenvector (E2A), and loss of subendocardial cardiomyocytes derived by reductions in the proportions of myocytes with right-handed orientation (
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Ehrler, Melanie, Ladina Schlosser, Peter Brugger, et al. "Altered white matter microstructure is related to cognition in adults with congenital heart disease." Brain Communications, December 28, 2020. http://dx.doi.org/10.1093/braincomms/fcaa224.

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Abstract Adults with congenital heart disease are at risk for persisting executive function deficits, which are known to affect academic achievement and quality of life. Alterations in white -matter microstructure are associated with cognitive impairments in adolescents with congenital heart disease. This study aimed to identify microstructural alterations potentially associated with executive function deficits in adults with congenital heart disease. Diffusion tensor imaging and tract-based spatial statistics were conducted in 45 patients (18 females) and 54 healthy controls (26 females) aged
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Chien, Billy, Salman Shahid, Rhea Thukral, and Yu-Chien Wu. "The effect of pathophysiologic protein accumulation in preclinical Alzheimer’s disease on white matter integrity." Proceedings of IMPRS 3 (December 15, 2020). http://dx.doi.org/10.18060/24566.

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Background: 
 Traditionally, the accumulation of amyloid beta peptides (Aβ) and tau proteins are considered the main pathological hallmarks of AD due to their impact on cortical microstructural organization, which leads to dendritic deficit and neuronal loss. Additionally, it is hypothesized that these pathophysiological processes may induce axonal and oligodendrocyte dysfunction exacerbating myelin impairment. The objective of this cross-sectional study is to estimate the degree of alterations in white matter (WM) microstructural organization associated with pathological proteins at the
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Suprano, Ilaria, Gabriel Kocevar, Claudio Stamile, et al. "White matter microarchitecture and structural network integrity correlate with children intelligence quotient." Scientific Reports 10, no. 1 (2020). http://dx.doi.org/10.1038/s41598-020-76528-x.

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AbstractThe neural substrate of high intelligence performances remains not well understood. Based on diffusion tensor imaging (DTI) which provides microstructural information of white matter fibers, we proposed in this work to investigate the relationship between structural brain connectivity and intelligence quotient (IQ) scores. Fifty-seven children (8–12 y.o.) underwent a MRI examination, including conventional T1-weighted and DTI sequences, and neuropsychological testing using the fourth edition of Wechsler Intelligence Scale for Children (WISC-IV), providing an estimation of the Full-Scal
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